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chr1:15,465,487-17,815,433

Best TWAS P=3.1e-20 · Best GWAS P=1.06e-31 conditioned to 1.22e-21

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Breast Mammary Tissue	RP11-169K16.9	0.18	0.01	enet	40	0.01	1.2e-01	-2.065	-6.0	2.2e-09	0.06	0.07	0.35	FALSE
2	GTEx	Breast Mammary Tissue (Male)	MST1L	0.19	-0.01	lasso	6	-0.01	6.7e-01	5.778	7.5	7.5e-14	0.56	0.02	0.47	TRUE
3	GTEx	Muscle Skeletal	RP11-169K16.9	0.09	0.03	enet	11	0.04	1.0e-04	10.085	-9.2	3.1e-20	0.04	0.02	0.97	TRUE
4	GTEx	Pancreas	RP4-798A10.2	0.18	0.01	lasso	6	0.06	1.8e-03	6.075	5.6	2.3e-08	-0.02	0.07	0.45	FALSE
5	GTEx	Thyroid	HSPB7	0.17	0.12	lasso	6	0.15	9.8e-12	5.561	5.4	7.6e-08	-0.04	1.00	0.00	FALSE
6	ROSMAP	Brain Pre-frontal Cortex	HSPB7	0.18	0.18	lasso	9	0.20	2.2e-25	6.075	5.4	6.8e-08	-0.05	1.00	0.00	FALSE
7	ROSMAP	Brain Pre-frontal Cortex	RP11-169K16.9	0.15	0.05	bslmm	414	0.11	3.8e-14	0.031	-6.2	6.3e-10	0.10	1.00	0.00	FALSE
8	ROSMAP	Brain Pre-frontal Cortex	CLCNKA	0.16	0.18	enet	15	0.21	1.4e-26	-3.720	5.3	1.0e-07	-0.04	1.00	0.00	FALSE
9	The Cancer Genome Atlas	Breast Invasive Carcinoma	ZBTB17	0.02	0.00	blup	69	0.01	5.0e-04	-1.426	-6.1	1.2e-09	-0.06	0.02	0.64	FALSE
10	The Cancer Genome Atlas	Colon Adenocarcinoma	CLCNKA	0.06	0.02	blup	62	0.03	9.8e-03	4.864	-7.2	8.8e-13	0.09	0.04	0.18	FALSE
11	The Cancer Genome Atlas	Brain Lower Grade Glioma	CLCNKA	0.02	0.02	blup	63	0.01	2.2e-02	-3.720	6.1	8.3e-10	-0.02	0.10	0.17	FALSE
12	The Cancer Genome Atlas	Brain Lower Grade Glioma	PADI1	0.04	0.03	enet	3	0.03	2.1e-04	6.414	6.2	5.3e-10	0.52	0.45	0.13	FALSE
13	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CLCNKB	0.18	0.03	blup	65	0.04	1.0e-02	-1.031	-5.5	4.3e-08	0.07	0.03	0.20	FALSE
14	The Cancer Genome Atlas	Prostate Adenocarcinoma	CLCNKA	0.22	0.28	lasso	10	0.28	7.8e-30	6.075	-6.8	1.1e-11	0.02	1.00	0.00	FALSE
15	The Cancer Genome Atlas	Prostate Adenocarcinoma	CLCNKB	0.03	0.03	lasso	2	0.01	1.1e-02	-4.849	-5.5	3.8e-08	0.08	0.02	0.54	FALSE
16	The Cancer Genome Atlas	Thyroid Carcinoma	FLJ37453	0.10	0.06	blup	36	0.05	1.2e-05	-2.007	-5.5	4.2e-08	0.07	0.89	0.01	FALSE
17	The Cancer Genome Atlas	Thyroid Carcinoma	HSPB7	0.34	0.42	enet	15	0.46	6.7e-49	5.177	6.7	2.7e-11	-0.03	1.00	0.00	FALSE