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chr3:121,435,624-123,672,874

Best TWAS P=2.69e-48 · Best GWAS P=7.86e-77 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	LOC100129550	0.08	0.10	lasso	6	0.09	3.8e-11	-9.49	9.8	6.6e-23	-0.65	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PARP14	0.05	0.04	lasso	5	0.03	3.9e-04	-8.71	8.6	1.3e-17	-0.49	0.79	0.02	FALSE
3	CommonMind	Brain Pre-frontal Cortex	SEMA5B	0.19	0.10	bslmm	519	0.11	1.1e-13	-10.80	-8.3	8.2e-17	0.45	1.00	0.00	FALSE
4	GTEx	Adrenal Gland	HSPBAP1	0.21	0.01	enet	20	0.05	6.6e-03	-5.26	-6.4	1.5e-10	0.28	0.16	0.04	FALSE
5	GTEx	Brain Cerebellum	RP11-67L2.2	0.34	0.02	lasso	4	0.04	1.9e-02	-9.49	10.3	8.5e-25	-0.66	0.04	0.67	TRUE
6	GTEx	Brain Hypothalamus	HSPBAP1	0.32	-0.01	lasso	15	0.05	2.5e-02	-14.47	-12.5	4.8e-36	0.58	0.08	0.09	FALSE
7	GTEx	Breast Mammary Tissue	PARP14	0.18	0.16	lasso	6	0.13	2.2e-07	-6.57	-6.0	1.6e-09	0.28	0.97	0.00	FALSE
8	GTEx	Cells EBV-transformed lymphocytes	HSPBAP1	0.24	0.18	lasso	11	0.23	4.8e-08	-14.57	-10.6	1.9e-26	0.61	0.60	0.06	FALSE
9	GTEx	Cells Transformed fibroblasts	DIRC2	0.19	0.07	lasso	6	0.08	1.3e-06	5.58	8.6	8.8e-18	-0.29	0.92	0.06	FALSE
10	GTEx	Colon Sigmoid	PARP14	0.39	0.29	lasso	6	0.26	1.2e-09	-6.57	-5.4	6.7e-08	0.25	1.00	0.00	FALSE
11	GTEx	Liver	SEC22A	0.21	-0.01	lasso	5	0.00	2.3e-01	1.12	-5.3	9.7e-08	0.22	0.10	0.15	TRUE
12	GTEx	Liver	RP11-299J3.8	0.24	-0.01	enet	15	0.00	3.4e-01	-2.21	-6.0	1.9e-09	0.27	0.06	0.24	FALSE
13	GTEx	Lung	HSPBAP1	0.20	0.04	lasso	10	0.11	8.4e-09	-14.57	-5.6	1.8e-08	0.33	0.95	0.00	TRUE
14	GTEx	Lung	PARP14	0.10	0.05	lasso	4	0.01	3.4e-02	-6.57	-6.6	5.1e-11	0.30	0.72	0.03	FALSE
15	GTEx	Muscle Skeletal	PARP14	0.11	0.10	lasso	5	0.09	6.7e-09	-6.57	-6.5	9.5e-11	0.30	1.00	0.00	FALSE
16	GTEx	Nerve Tibial	DIRC2	0.20	0.12	lasso	5	0.12	1.8e-08	-9.49	-8.4	4.5e-17	0.58	0.98	0.00	FALSE
17	GTEx	Nerve Tibial	RP11-67L2.2	0.17	0.13	lasso	8	0.11	4.2e-08	-9.49	10.2	2.1e-24	-0.64	0.57	0.43	FALSE
18	GTEx	Pituitary	HSPBAP1	0.48	0.01	lasso	10	0.03	6.9e-02	-10.41	-6.3	3.5e-10	0.28	0.07	0.07	FALSE
19	GTEx	Skin Not Sun Exposed Suprapubic	HSPBAP1	0.18	0.02	lasso	4	0.02	2.3e-02	-14.57	-8.0	9.1e-16	0.55	0.18	0.14	FALSE
20	GTEx	Small Intestine Terminal Ileum	HSPBAP1	0.39	0.11	enet	61	0.14	6.3e-04	-14.57	-10.2	1.9e-24	0.58	0.10	0.73	FALSE
21	GTEx	Spleen	HSPBAP1	0.48	0.37	lasso	2	0.36	4.2e-10	-14.57	-14.3	2.6e-46	0.79	0.22	0.76	FALSE
22	GTEx	Spleen	PARP14	0.30	0.15	lasso	10	0.15	9.6e-05	-7.61	8.0	9.5e-16	-0.47	0.19	0.22	TRUE
23	GTEx	Testis	HSPBAP1	0.25	0.17	lasso	4	0.18	1.5e-08	-6.59	6.0	1.9e-09	-0.29	0.94	0.00	FALSE
24	GTEx	Thyroid	PARP14	0.14	0.07	lasso	4	0.06	3.5e-05	-14.57	10.5	6.7e-26	-0.57	0.90	0.02	FALSE
25	GTEx	Thyroid	RP11-67L2.2	0.15	0.00	enet	22	0.02	1.2e-02	5.65	13.0	8.0e-39	-0.61	0.01	0.97	FALSE
26	GTEx	Whole Blood	HSPBAP1	0.12	0.03	lasso	5	0.03	8.4e-04	-14.57	-9.2	4.8e-20	0.45	0.33	0.46	FALSE
27	METSIM	Adipose	HSPBAP1	0.10	0.04	enet	33	0.06	8.7e-10	-14.47	-9.6	5.7e-22	0.52	0.48	0.52	FALSE
28	METSIM	Adipose	PARP14	0.21	0.14	lasso	11	0.16	7.8e-23	-8.58	5.8	5.9e-09	-0.35	1.00	0.00	FALSE
29	METSIM	Adipose	RP11-67L2.2	0.04	0.00	bslmm	498	0.01	3.1e-03	-11.68	12.6	1.2e-36	-0.67	0.05	0.88	FALSE
30	NTR	Blood	DIRC2	0.02	0.02	lasso	5	0.02	1.0e-07	5.96	-5.5	3.4e-08	0.19	1.00	0.00	FALSE
31	NTR	Blood	HSPBAP1	0.18	0.17	enet	20	0.21	6.4e-65	-14.47	-14.6	2.7e-48	0.74	1.00	0.00	TRUE
32	NTR	Blood	KPNA1	0.02	0.00	enet	36	0.01	1.6e-03	-14.47	7.6	3.9e-14	-0.50	0.16	0.46	FALSE
33	NTR	Blood	PARP14	0.05	0.02	bslmm	570	0.03	1.3e-10	-8.71	6.5	6.2e-11	-0.51	0.98	0.02	FALSE
34	NTR	Blood	PARP15	0.30	0.25	bslmm	532	0.26	2.4e-85	-5.90	-5.9	3.3e-09	0.21	1.00	0.00	FALSE
35	YFS	Blood	DIRC2	0.27	0.13	enet	19	0.27	8.1e-89	5.65	-8.6	7.6e-18	0.49	1.00	0.00	FALSE
36	YFS	Blood	PARP14	0.20	0.22	enet	41	0.23	3.4e-73	-8.58	5.8	5.9e-09	-0.39	1.00	0.00	FALSE
37	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	HSPBAP1	0.03	0.01	blup	62	0.01	4.5e-02	-6.38	12.4	2.2e-35	-0.69	0.03	0.30	TRUE
38	The Cancer Genome Atlas	Breast Invasive Carcinoma	HSPBAP1	0.02	0.01	blup	63	0.01	2.8e-03	-13.74	14.0	2.6e-44	-0.67	0.03	0.09	FALSE
39	The Cancer Genome Atlas	Brain Lower Grade Glioma	HSPBAP1	0.06	0.04	blup	63	0.05	1.5e-06	-2.01	7.8	4.6e-15	-0.49	0.70	0.14	FALSE
40	The Cancer Genome Atlas	Brain Lower Grade Glioma	LOC100129550	0.03	0.02	blup	45	0.03	1.7e-04	-5.87	7.2	8.1e-13	-0.50	0.08	0.44	FALSE
41	The Cancer Genome Atlas	Brain Lower Grade Glioma	PARP15	0.09	0.04	blup	86	0.04	1.8e-05	0.35	-5.5	3.3e-08	0.26	0.86	0.02	FALSE
42	The Cancer Genome Atlas	Lung Adenocarcinoma	HSPBAP1	0.06	0.02	lasso	3	0.03	2.0e-04	1.65	5.4	5.4e-08	-0.31	0.30	0.12	FALSE
43	The Cancer Genome Atlas	Prostate Adenocarcinoma	LOC100129550	0.04	0.01	blup	45	0.01	6.5e-02	-9.49	-12.3	1.1e-34	0.61	0.01	0.48	TRUE
44	The Cancer Genome Atlas	Stomach Adenocarcinoma	DIRC2	0.13	0.00	lasso	4	0.00	4.3e-01	9.17	-6.0	2.1e-09	0.43	0.01	0.03	FALSE
45	The Cancer Genome Atlas	Stomach Adenocarcinoma	HSPBAP1	0.07	0.04	blup	62	0.04	6.6e-04	-2.97	9.6	6.7e-22	-0.54	0.12	0.26	TRUE
46	The Cancer Genome Atlas	Thyroid Carcinoma	DIRC2	0.08	0.05	lasso	2	0.05	2.0e-05	5.51	5.9	2.8e-09	-0.09	0.74	0.02	FALSE
47	The Cancer Genome Atlas	Thyroid Carcinoma	HSPBAP1	0.18	0.03	blup	63	0.09	5.1e-09	5.58	10.3	7.6e-25	-0.35	0.84	0.02	FALSE
48	The Cancer Genome Atlas	Thyroid Carcinoma	LOC100129550	0.08	0.03	blup	45	0.02	3.0e-03	-9.55	13.3	1.5e-40	-0.68	0.02	0.06	FALSE
49	The Cancer Genome Atlas	Thyroid Carcinoma	PARP15	0.06	0.03	blup	86	0.02	3.4e-03	-2.81	-6.7	2.4e-11	0.29	0.04	0.17	FALSE