Hub : Genes

DIRC2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.191	0.0580	2.9e-04	0.073	NA	0.067	NA	0.080	3.6e-06	NA	9.0e-06	NA	1.3e-06
2	GTEx	Nerve Tibial	0.199	0.0534	3.0e-05	0.124	NA	0.096	NA	0.115	4.7e-09	NA	2.7e-07	NA	1.7e-08
3	NTR	Blood	0.025	0.0092	6.3e-04	0.020	0.007	0.020	0.018	0.022	2.6e-07	2.5e-03	4.5e-07	1.1e-06	1.0e-07
4	YFS	Blood	0.265	0.0299	0.0e+00	0.127	0.245	0.271	0.244	0.265	2.4e-39	3.6e-79	8.1e-89	9.6e-79	1.7e-86
5	TCGA	Brain Lower Grade Glioma	0.110	0.0460	5.4e-05	0.023	0.024	0.059	NA	0.063	1.0e-03	9.0e-04	3.1e-07	NA	1.1e-07
6	TCGA	Stomach Adenocarcinoma	0.127	0.0750	7.4e-03	-0.002	-0.003	-0.004	NA	-0.001	4.9e-01	6.4e-01	7.8e-01	NA	4.3e-01
7	TCGA	Thyroid Carcinoma	0.082	0.0380	5.6e-04	0.051	0.026	0.041	NA	0.047	9.9e-06	1.4e-03	6.7e-05	NA	2.0e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.3	0.4	0.9	1.0	-0.6	-0.3	-0.6	-0.1	-0.7	0.9
Bipolar Disorder or Schizophrenia	0.6	1.4	2.8	1.7	1.3	-1.4	0.3	0.7	0.8	1.5
Depressed Affect (Nagel 2018)	2.4	5.1	10.8	-2.3	-3.3	1.9	-1.2	-2.2	-2.4	-1.9
Depression (Nagel 2018)	0.6	0.9	2.0	-1.4	-1.1	1.4	-0.0	-0.4	-0.3	-0.9
Intelligence (Savage-Jansen 2018)	0.3	0.8	2.4	0.5	0.7	-0.6	-0.2	1.1	1.6	0.9
Neuroticism (Nagel 2018)	1.1	2.6	6.5	-2.5	-1.5	2.0	0.2	-1.0	-1.0	-1.9
Schizophrenia (2018)	0.9	2.0	4.3	1.4	2.1	-1.5	0.8	1.0	1.5	1.2
Schizophrenia vs Biploar Disorder	1.4	1.8	4.5	0.7	2.1	-0.2	1.5	2.1	0.6	0.8
Worry (Nagel 2018)	1.3	2.8	7.4	-2.7	-0.8	2.3	1.0	-0.5	-0.7	-2.2
Alzheimer’s Disease (in mother)	1.3	1.5	2.6	-1.6	1.2	0.9	1.4	1.3	0.8	-1.1
Alzheimer’s Disease (in father)	1.0	1.1	2.8	-1.7	-0.6	1.0	-0.1	-0.5	1.4	-1.0
Alzheimer’s Disease (including proxy)	1.5	2.1	6.1	-2.5	0.0	1.8	1.1	0.5	1.1	-1.7
Crohns Disease (2017)	0.7	1.4	3.1	1.1	-1.4	-1.2	-1.8	-0.3	0.2	1.5
Irritable Bowel Disease (IBD)	0.8	1.9	4.8	1.5	0.4	-1.5	-0.9	1.4	1.0	2.2
Ulcerative Colitis (UC)	1.5	2.9	6.4	1.2	2.0	-1.1	0.4	2.5	1.9	1.9
Major Depression (MDD)	0.7	0.8	2.5	-0.9	-0.2	0.7	0.2	-0.8	-1.1	-1.6
Reaction Time	0.5	0.9	2.1	-1.0	-1.1	1.0	-0.2	-0.7	-1.5	-0.8
Verbal and Numeric Reasoning (VNR)	0.3	0.8	3.6	0.4	0.9	-0.5	0.2	0.7	1.9	0.6
Breast Cancer	0.3	0.8	2.9	1.7	0.9	-1.0	0.3	0.5	0.3	0.8
Ovarian Cancer	1.3	1.7	6.3	0.3	2.5	-0.4	1.9	1.3	0.1	-0.4
Prostate Cancer	0.4	0.6	1.7	-1.2	-0.2	0.7	0.0	-0.4	1.3	-0.7
Age at First Birth	1.4	2.0	5.6	0.4	-2.4	-0.1	-1.8	-0.6	-1.9	0.9
Bipolar Disorder (2011)	0.8	0.8	1.7	0.6	-1.0	-0.9	-1.3	-0.9	0.2	0.7
Body Mass Index (BMI) (2010)	1.0	1.4	7.1	0.7	2.7	-0.8	1.1	0.7	0.2	0.0
Coronary Artery Disease (CAD)	0.6	0.7	1.8	0.6	-0.3	-1.3	-1.2	-0.3	0.5	0.8
Crohns Disease (2012)	0.2	0.3	0.7	-0.8	-0.8	0.2	-0.5	-0.3	0.7	-0.3
Mean Putamen Volume	2.0	2.3	5.2	-0.3	1.8	0.4	1.9	2.3	1.9	-0.2
Fasting Glucose	0.1	0.1	0.4	-0.6	-0.3	0.3	-0.3	0.4	-0.1	0.1
HbA1C	5.9	6.5	11.2	-3.3	2.0	2.8	2.9	0.8	1.5	-3.3
HDL Cholesterol	0.3	0.5	1.1	1.0	0.2	-0.9	-0.3	0.1	-0.9	0.8
LDL Cholesterol	0.5	0.8	2.3	1.0	-0.8	-0.7	-0.7	-0.5	-1.5	0.4
Lupus	0.3	0.4	2.0	-0.1	-0.7	0.1	-0.3	-0.3	-1.4	-0.0
Neuroticism (2016)	0.2	0.3	0.5	-0.7	-0.7	0.1	-0.7	-0.5	-0.6	-0.5
Primary Biliary Cirrhosis	1.1	1.5	3.9	1.1	0.2	-1.2	-1.0	0.8	2.0	1.6
Rheumatoid Arthritis	0.6	0.8	4.8	0.4	-0.1	0.4	0.6	0.1	-2.2	-0.3
Schizophrenia (2014)	1.5	3.3	4.9	1.9	2.1	-1.8	0.6	1.9	1.6	2.2
Triglycerides	0.6	0.9	1.7	1.3	-0.5	-1.0	-0.7	-1.1	-1.2	0.6
Type 2 Diabetes (T2D) (2012)	1.0	1.1	2.9	-1.4	-0.2	1.7	1.3	0.7	0.1	-0.8
Ulcerative Colitis	1.9	2.7	6.1	0.3	2.1	-0.5	0.9	2.5	2.5	1.2
Blood Eosinophil Count	0.2	1.5	3.3	-0.3	1.6	0.3	1.4	1.6	1.8	-0.2
Blood Platelet Count	0.1	1.6	4.8	0.1	-2.2	0.5	-1.3	-1.4	-1.6	-0.3
Blood Red Count	0.2	2.3	6.2	-0.0	-2.2	0.1	-1.2	-2.5	-1.9	-0.3
Blood White Count	0.6	4.2	9.4	3.1	-0.6	-2.9	-2.4	-0.7	-0.3	2.2
Heel T-Score	0.1	0.8	1.8	1.1	-1.3	-0.9	-1.0	-0.1	0.1	1.1
BMI	0.8	4.8	9.0	2.7	1.2	-2.9	-1.2	1.0	2.2	3.0
Height	0.2	3.1	5.3	-1.9	-1.3	2.3	1.7	-0.9	-1.6	-2.3
Waist Hip Ratio (WHR)	0.4	1.8	3.9	1.4	-2.0	-0.5	-1.5	-1.7	-0.6	1.0
Systolic Blood Pressure	0.1	0.6	2.6	-0.1	-0.5	0.8	-0.1	-0.4	-1.6	-0.6
Smoking Status	0.5	1.1	3.5	-0.1	1.9	-0.7	0.9	1.4	1.0	0.3
Allergy or Eczema	0.1	0.2	0.5	0.6	0.7	-0.3	0.2	-0.4	0.7	-0.2
Cardiovascular Disease	0.1	0.3	0.6	0.6	-0.2	-0.5	-0.8	-0.7	-0.8	-0.2
Hypothyroidism (self reported)	0.7	1.6	3.2	-1.3	1.1	1.5	1.8	1.1	0.5	-1.2
Respiratory disease	0.3	0.6	1.3	-0.7	1.1	0.2	0.7	0.6	0.9	-0.6
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.3	0.6	-0.9	-0.8	-0.9	-0.0	-0.4	1.1
Lung FEV1/FVC ratio	0.2	0.9	2.2	0.8	1.5	-0.5	0.6	0.7	1.1	1.2
Lung FVC	0.1	0.6	1.9	-0.7	0.3	1.2	1.4	0.5	-0.3	-0.3
Neuroticism	0.6	1.3	2.5	-1.3	-1.6	1.1	-0.4	-0.8	-1.5	-1.0
Chronotype (morning person)	0.6	1.5	3.8	2.0	0.5	-1.5	-0.7	0.4	-0.5	1.8
Hair Pigment	1.7	47.8	74.0	8.6	-8.4	-5.5	-8.6	-3.9	-6.0	5.9
Tanning	0.1	0.8	3.0	-0.6	1.0	-0.1	0.7	0.1	1.7	-0.7
Hand grip strength (left)	0.7	1.8	4.6	-0.8	1.9	0.9	2.1	1.4	-0.2	-0.9
Number of treatments/medications taken	0.6	1.1	2.6	-1.0	-1.2	0.7	-0.5	-1.6	0.1	-1.4
Average weekly spirits intake	1.3	1.6	3.0	-1.2	-1.7	1.2	-0.0	-1.7	-0.3	-1.6
Sensitivity / hurt feelings	1.3	2.2	4.4	-1.1	-1.7	1.0	-0.6	-2.1	-1.7	-1.6
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.6	0.5	-1.0	-0.7	-1.2	-0.9	-0.3	0.5
Hearing difficulty/problems: Yes	0.5	0.8	3.3	-0.5	0.6	0.6	0.6	1.8	0.7	0.4
Relative age of first facial hair	1.3	2.6	6.5	0.5	2.5	0.3	2.1	2.2	1.4	0.0
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	5.2	0.2	-2.3	-0.0	-1.8	-1.7	-0.4	0.2
Ever used hormone-replacement therapy (HRT)	1.5	2.0	3.4	0.8	-1.8	-0.7	-1.7	-1.6	-1.8	0.6
Ever had hysterectomy (womb removed)	0.4	0.5	0.9	-0.1	-1.0	-0.6	-0.9	-0.5	-0.8	0.6
Systolic blood pressure, automated reading	0.1	0.2	1.2	-0.1	0.4	0.4	0.2	1.1	0.1	0.4
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	3.8	-0.3	-0.9	-0.1	-0.7	-0.6	1.9	-0.2
Angina	4.3	5.6	12.4	2.0	-2.4	-2.6	-3.5	-2.6	-0.9	1.6
Medication for hormone replacement therapy	0.2	0.3	0.8	-0.2	-0.6	0.2	-0.3	-0.9	-0.4	-0.5
Vitamin and mineral supplements	0.0	0.1	0.1	0.3	0.0	-0.2	-0.2	-0.3	0.3	-0.0
Supplements: Zinc	0.3	0.3	0.7	0.4	-0.7	-0.4	-0.7	-0.2	0.0	0.8
Medication: Co-codamol	0.2	0.3	0.7	-0.2	0.5	0.3	0.5	-0.1	-0.8	-0.8
Medication: Metformin	0.7	1.0	1.5	1.1	-1.1	-1.0	-1.2	-1.0	-0.3	0.9
Diabetes (father)	0.1	0.1	0.2	0.2	0.3	-0.2	0.4	0.4	0.1	0.1
Diabetes (mother)	3.3	4.2	9.3	1.7	-2.6	-2.1	-3.1	-1.8	-0.9	1.3
Severe depression (siblings)	0.7	0.8	2.4	0.3	-1.4	-0.4	-1.5	-0.1	0.6	0.9
Pack years adult smoking proportion	0.5	0.8	1.9	-0.4	-0.4	-0.9	-1.4	-1.1	1.1	-0.1
Impedance of leg (right)	0.1	0.6	1.4	-0.8	-0.6	1.2	0.7	0.3	-0.7	-0.8
Leg fat-free mass (left)	0.1	0.3	0.8	0.7	0.0	-0.9	-0.4	-0.5	0.7	0.5
Trunk fat percentage	0.4	1.5	2.6	1.2	-0.4	-1.6	-1.5	-1.0	1.4	1.0
Hand grip strength (right)	0.3	0.9	2.3	-0.5	1.2	0.6	1.5	1.3	0.4	-0.2
Townsend deprivation index at recruitment	0.2	0.3	0.6	0.6	0.1	-0.8	-0.3	-0.3	0.4	0.7
Current tobacco smoking	1.1	1.7	5.9	1.8	0.5	-2.4	-0.9	-0.5	0.7	1.1
Average weekly fortified wine intake	0.9	1.1	2.4	0.5	-1.4	-0.5	-1.6	-1.4	-0.6	0.6
Maternal smoking around birth	1.6	2.4	5.0	-0.6	2.2	0.9	2.2	1.8	1.3	-0.7
Fed-up feelings	1.3	2.4	6.1	-1.7	-2.5	1.5	-0.9	-1.5	-0.6	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	3.8	-1.3	-2.0	1.4	-0.5	-1.4	-0.5	-0.9
Relative age voice broke	0.8	1.2	3.2	0.4	1.6	0.0	1.1	1.8	1.2	0.4
Taking other prescription medications	0.3	0.5	1.1	-0.7	-0.8	0.5	-0.4	-1.0	0.2	-0.8
Age when periods started (menarche)	0.2	0.4	1.0	0.5	1.0	-0.5	0.3	-0.9	0.4	-0.5
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.6	0.3	-1.1	-0.9	-1.3	-0.1	0.3	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.3	0.3	0.3	-0.5	0.0	0.1	-0.5	0.1
Tinnitus: Yes, but not now, but have in the past	2.7	2.9	6.4	-2.5	-0.0	2.5	1.4	0.6	0.4	-2.3
Qualifications: CSEs or equivalent	0.3	0.4	0.6	-0.6	-0.1	0.8	0.7	0.7	-0.6	-0.6
Serious illness, injury or assault to yourself	1.0	1.2	3.4	0.5	-1.3	-0.9	-1.8	-1.4	-0.0	0.6
High blood pressure	0.4	1.0	2.5	-1.3	-0.7	1.0	-0.4	-0.9	-0.6	-1.6
Hayfever, allergic rhinitis or eczema	0.4	0.9	3.0	0.3	1.7	-0.0	1.1	1.1	1.0	0.1
Multivitamins +/- minerals	0.7	0.9	2.0	0.7	-1.1	-0.8	-1.0	-0.8	-1.4	0.7
Stomach or abdominal pain in last month	0.1	0.1	0.2	0.3	0.0	-0.4	-0.4	-0.3	0.3	-0.2
Supplements: Glucosamine	0.7	0.9	2.3	-1.3	-0.1	1.5	0.9	0.3	-0.9	-0.9
Diverticular disease/diverticulitis (self-reported)	1.0	1.1	3.4	0.5	1.8	-0.9	0.6	0.6	1.6	0.5
Medication: Atenolol	0.2	0.2	0.7	0.5	-0.5	0.0	-0.2	-0.8	-0.0	-0.7
Medication: Levothyroxine sodium	1.5	2.6	4.4	-2.1	1.3	1.9	2.0	0.7	0.3	-2.0
Sitting height	0.7	5.2	10.2	-3.0	1.3	2.7	3.2	1.5	0.7	-2.4
Chronic bronchitis/emphysema (father)	3.9	4.5	9.1	-2.9	1.0	3.0	2.8	0.8	0.0	-2.3
High blood pressure (mother)	2.3	3.2	6.8	2.5	0.9	-2.6	-1.3	-0.2	1.5	2.1
Body mass index (BMI)	0.5	2.2	4.6	1.8	0.2	-2.1	-1.6	-0.4	1.4	1.9
Impedance of leg (left)	0.1	0.7	1.4	-1.0	-0.4	1.2	0.7	0.4	-0.7	-0.9
Leg predicted mass (left)	0.1	0.4	0.9	0.8	0.0	-0.9	-0.5	-0.5	0.6	0.6
Trunk fat mass	0.3	1.4	2.7	1.3	-0.3	-1.6	-1.3	-0.9	1.1	1.1
Waist circumference	0.4	1.6	2.9	1.5	-0.5	-1.7	-1.5	-1.3	0.6	1.2
Number of incorrect matches in round	2.0	3.3	9.2	-1.6	-1.2	1.6	0.1	-1.8	-3.0	-2.2
Past tobacco smoking	0.4	0.7	1.7	0.7	-1.2	-0.4	-1.3	-0.7	-0.6	0.3
Alcohol usually taken with meals	0.9	1.4	3.2	-1.6	-0.1	1.8	1.1	0.0	-1.1	-1.3
Nervous feelings	1.6	2.9	5.0	-1.9	-1.5	1.6	-0.2	-2.1	-1.5	-2.2
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.9	-1.3	-0.0	1.4	0.7	0.1	0.2	-1.2
Hearing difficulty/problems with background noise	0.5	0.8	1.7	1.0	1.0	-1.3	-0.2	0.7	0.5	1.1
Hair/balding pattern: Pattern 2	1.3	1.7	4.2	0.2	-1.6	-0.7	-1.8	-2.0	-1.1	0.2
Had menopause	0.3	0.3	0.6	-0.5	-0.8	0.5	-0.6	-0.6	-0.5	-0.2
Had other major operations	2.4	3.0	5.8	1.5	-1.8	-1.5	-2.0	-1.2	-2.4	1.3
Forced vital capacity (FVC)	0.2	0.8	2.4	-0.6	0.3	1.2	1.6	0.9	-0.5	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.3	1.3	-0.0	-1.5	-1.0	0.4	-0.1	1.2
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.2	-0.2	1.2	0.4	1.5	1.0	0.2	-0.3
Qualifications: None of the above	0.2	0.4	1.5	-0.5	-0.3	0.5	-0.1	-0.8	-0.3	-1.2
Financial difficulties in last 2 years	0.0	0.0	0.0	-0.0	0.0	0.2	0.0	0.1	-0.1	-0.0
Mouth/teeth dental problems	2.6	4.0	9.7	-1.1	2.8	1.7	3.1	2.2	0.7	-1.1
Heart attack	1.6	2.0	3.1	-1.5	-1.2	1.5	0.2	-1.6	-1.6	-1.8
Allergy	0.6	1.4	3.8	0.9	-1.9	-0.7	-1.5	-0.3	-0.8	1.3
Pain all over the body in last month	0.1	0.1	0.2	0.4	0.3	-0.4	-0.1	-0.1	0.4	0.4
Diabetes (self-reported)	1.2	1.8	2.6	1.3	-1.3	-1.2	-1.6	-1.5	-1.3	1.1
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.9	0.6	-0.6	-0.3	-0.9	-0.7	-0.5	0.1
Medication: Ramipril	0.5	0.6	2.0	0.2	-0.8	0.1	-0.3	-1.4	-1.2	-0.5
Medication: Simvastatin	0.9	1.3	3.2	0.3	-1.8	-0.5	-1.4	-1.7	-0.8	0.1
Fluid intelligence score	0.7	1.4	2.5	1.2	-0.3	-1.3	-1.2	-0.3	1.6	1.4
Illnesses of siblings	2.2	3.1	5.5	2.3	-1.0	-2.2	-2.2	-1.3	-0.0	2.0
Neuroticism score	0.6	1.2	3.6	-0.7	-1.9	0.5	-1.0	-1.1	-1.2	-0.5
Weight	0.1	0.6	1.3	0.8	-0.2	-1.1	-0.8	-0.7	0.8	0.8
Impedance of arm (right)	0.1	0.5	1.0	-0.6	-0.8	0.5	-0.2	-1.0	-0.3	-0.9
Arm fat percentage (right)	0.6	2.5	4.9	1.9	-0.2	-2.2	-1.8	-0.7	1.2	2.0
Trunk fat-free mass	0.0	0.0	0.1	0.2	-0.1	-0.1	0.2	-0.3	-0.3	0.2
Hip circumference	0.2	1.1	2.2	1.0	0.8	-1.5	-0.7	-0.3	1.5	1.0
Time employed in main current job	0.7	0.9	1.6	-1.1	1.0	0.6	1.3	0.7	0.8	-0.8
Alcohol intake versus 10 years previously	0.1	0.1	0.3	-0.6	0.1	0.0	-0.2	0.4	-0.2	-0.1
Father’s age at death	0.4	0.6	2.0	0.6	-1.1	0.2	-0.5	-1.4	-0.2	-0.5
Worrier / anxious feelings	0.3	0.6	2.3	-0.4	1.1	-0.1	0.6	0.5	1.5	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	2.8	0.6	-0.8	-1.1	-1.7	0.0	1.3	1.5
Falls in the last year	0.6	0.8	1.5	0.5	1.2	-1.2	-0.2	0.8	1.1	0.8
Hair/balding pattern: Pattern 3	0.1	0.2	0.5	-0.2	-0.7	0.4	-0.4	-0.0	-0.6	0.1
Number of live births	0.5	0.7	2.3	0.0	-1.4	-0.1	-1.5	-0.8	-0.1	0.3
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	2.1	-0.2	0.8	0.8	1.5	1.1	0.0	-0.2
Pulse rate	1.3	2.2	5.2	0.9	-2.3	-0.7	-2.0	-2.0	-0.3	0.7
Happiness	2.0	2.4	4.5	-1.9	1.4	1.4	1.7	-0.3	1.4	-2.1
Noisy workplace	1.4	1.7	2.8	-1.6	1.1	1.2	1.7	0.7	0.7	-1.7
Qualifications: A levels/AS levels or equivalent	0.4	0.8	2.6	-0.9	0.2	1.6	1.2	0.2	0.0	-1.0
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	6.6	-0.0	1.6	-0.1	0.7	1.2	2.6	0.0
Mouth/teeth dental problems: Dentures	0.4	0.8	2.0	-0.1	-1.0	-0.5	-1.0	-1.4	1.0	-0.1
Asthma	0.7	1.3	1.7	-1.3	1.1	1.0	1.3	0.7	1.3	-1.2
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	1.9	0.8	-0.6	-1.0	-1.4	-0.1	0.5	1.0
Medication: Cholesterol lowering	0.3	0.5	1.9	0.5	-0.3	-0.8	-0.7	-1.4	-0.5	-0.1
Depression (self-reported)	0.3	0.4	1.2	0.2	-0.8	-0.6	-1.1	-0.5	-0.3	0.3
Medication: Lansoprazole	1.1	1.2	6.2	0.5	-1.2	-0.2	-0.4	-0.5	-2.5	0.3
Prospective memory result	1.1	1.4	2.6	-1.1	-1.0	1.5	0.6	-0.6	-1.6	-1.4
Lung cancer (father)	0.8	0.9	1.9	-1.4	-0.8	1.1	-0.2	-1.0	-0.3	-1.3
Illnesses of mother	1.9	2.4	4.6	-2.0	0.9	2.1	2.0	1.1	-0.1	-1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	4.0	-0.5	1.7	0.8	2.0	1.9	0.5	-0.3
Pulse wave Arterial Stiffness index	0.2	0.3	1.1	-0.1	-0.7	-0.2	-0.5	-1.0	0.2	-0.1
Impedance of arm (left)	0.2	0.8	1.5	-0.9	-1.2	1.0	-0.2	-0.8	-0.5	-1.0
Arm fat mass (right)	0.6	2.5	4.8	1.9	-0.4	-2.2	-1.9	-0.9	1.0	1.9
Trunk predicted mass	0.0	0.1	0.1	0.2	-0.2	-0.1	0.1	-0.4	-0.4	0.2
Standing height	0.3	2.6	4.8	-2.0	-0.6	2.1	1.7	-0.4	-1.1	-2.2
Length of working week for main job	0.9	1.0	2.4	1.2	0.6	-1.0	-0.4	0.6	1.2	1.6
Exposure to tobacco smoke at home	0.3	0.3	0.8	-0.7	0.8	0.3	0.5	-0.2	0.2	-0.9
Breastfed as a baby	0.2	0.3	0.9	0.0	0.1	-0.2	-0.2	0.7	1.0	0.6
Tense / ‘highly strung’	0.7	1.2	3.0	-1.4	-1.0	1.7	0.4	-0.4	-0.5	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	2.2	3.3	10.7	-1.9	-1.4	1.4	-0.1	-1.3	-3.3	-1.9
Hair/balding pattern: Pattern 4	0.9	2.2	4.6	-0.9	2.1	0.9	1.9	0.8	1.5	-1.6
Birth weight of first child	0.4	0.7	3.1	0.0	1.8	-0.5	0.8	0.4	0.8	-0.7
Peak expiratory flow (PEF)	0.7	1.6	5.1	0.8	1.1	-0.6	0.3	2.3	1.5	1.4
Pulse wave reflection index	0.7	0.9	1.7	-1.3	0.5	1.1	1.3	0.4	-0.2	-1.2
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.6	-0.2	-0.1	0.1	0.1	1.1	1.3	0.7
Loud music exposure frequency	2.6	2.8	5.9	-1.8	0.8	2.4	2.0	2.0	-0.8	-1.3
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	4.2	0.1	0.3	-0.2	0.2	0.6	2.1	0.3
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.0	-0.5	-1.0	0.0	-0.9	-0.9	-0.3	-0.3
Blood clot in the leg (DVT)	1.4	1.7	5.3	0.7	-1.6	-0.7	-1.5	-2.3	-1.1	-0.2
Medication: Paracetamol	0.1	0.2	0.6	-0.4	0.6	0.4	0.4	0.7	0.4	-0.2
Headache pain in last month	0.2	0.4	0.8	0.2	-0.8	-0.1	-0.7	-0.8	-0.9	-0.5
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	3.3	-0.6	0.8	0.6	1.0	1.8	0.6	0.2
Glaucoma (self-reported)	1.0	1.2	2.6	-1.1	-0.7	1.4	0.3	-1.4	0.2	-1.6
Gout (self-reported)	0.1	0.1	0.4	-0.0	-0.7	0.2	0.0	0.4	-0.4	0.3
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	1.0	-0.7	0.5	0.9	0.8	0.1	-0.2	-1.0
Medication: Amlodipine	0.7	1.0	2.7	-0.0	-1.6	0.1	-1.0	-1.5	-1.0	-0.5
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.8	0.2	0.1	-0.3	-0.5	0.5	0.5	0.9
Birth weight	1.0	2.1	5.4	-0.6	2.3	0.5	2.0	1.0	1.4	-1.1
Chronic bronchitis/emphysema (mother)	0.9	1.0	2.3	-1.5	-0.1	1.5	0.8	0.6	0.5	-1.2
High blood pressure (siblings)	1.6	2.3	4.8	-0.8	2.2	0.5	2.0	2.1	1.2	-0.3
Forced vital capacity (FVC), Best measure	0.6	2.4	5.9	-1.1	1.6	1.4	2.4	2.1	0.2	-0.7
Body fat percentage	0.5	2.1	4.1	1.6	-0.3	-2.0	-1.7	-0.9	1.5	1.5
Leg fat percentage (right)	0.5	1.9	3.5	1.7	-0.1	-1.9	-1.4	-0.3	1.4	1.7
Arm fat-free mass (right)	0.1	0.3	0.8	0.9	-0.3	-0.8	-0.4	-0.2	-0.1	0.8
Exposure to tobacco smoke outside home	2.0	2.7	6.1	-1.8	-0.9	1.7	0.4	-1.1	-2.5	-2.2
Comparative body size at age 10	0.3	0.8	2.3	1.0	0.2	-1.2	-0.8	0.1	0.6	1.5
Number of full brothers	2.0	2.6	4.4	-2.1	1.0	2.0	2.0	0.4	0.4	-2.1
Worry too long after embarrassment	0.3	0.6	1.6	-0.1	0.8	-0.1	0.7	1.3	1.1	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.9	-0.8	-0.4	0.6	0.2	-0.7	-1.7	-0.8
Wheeze or whistling in the chest in last year	1.1	1.9	4.7	-1.9	-0.4	1.7	0.9	-0.6	-0.9	-2.2
Number of children fathered	2.3	2.6	5.1	-1.4	2.2	1.2	2.3	0.3	-0.1	-2.1
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.8	-0.8	0.4	1.0	1.3	0.3	0.2	-1.1
Age at first live birth	0.2	0.3	0.8	-0.0	-0.6	0.5	0.2	-0.9	-0.4	-0.7
Pulse wave peak to peak time	0.4	0.5	1.9	-0.1	0.8	0.4	0.8	1.4	-0.1	0.1
Health satisfaction	0.2	0.3	0.8	0.2	0.5	-0.6	0.4	-0.9	0.5	-0.3
Shortness of breath walking on level ground	0.2	0.2	0.8	0.4	0.9	-0.6	0.4	0.2	0.3	0.1
Qualifications: College or University degree	0.3	1.0	2.2	-0.3	1.0	1.1	1.4	1.5	0.9	-0.1
Eye problems/disorders: None of the above	2.3	2.6	6.6	0.9	2.2	-1.1	1.3	2.6	1.1	1.6
Mouth/teeth dental problems: Loose teeth	1.0	1.2	4.2	0.1	-1.4	-0.4	-1.4	-2.1	-0.4	-0.1
Emphysema/chronic bronchitis	0.1	0.1	0.4	0.0	0.4	-0.3	0.2	0.2	0.7	-0.1
Medication for pain relief, constipation, heartburn	0.2	0.3	0.7	-0.2	0.7	0.2	0.9	0.2	-0.8	-0.3
Neck or shoulder pain in last month	0.0	0.0	0.1	0.0	0.1	-0.2	-0.1	-0.0	-0.1	0.0
Medication: Blood pressure	0.3	0.5	1.6	-0.4	-0.4	0.2	-0.2	-1.3	-0.2	-1.0
Angina (self-reported)	3.9	5.2	12.0	1.7	-2.5	-2.4	-3.5	-2.6	-0.8	1.4
Migraine (self-reported)	0.9	1.1	2.3	-1.1	1.0	1.2	1.5	0.8	0.2	-1.2
Medication: Ibuprofen	0.7	0.9	2.5	0.8	-0.7	-1.0	-1.6	-0.7	0.5	0.9
Medication: Allopurinol	0.2	0.3	0.6	-0.7	-0.4	0.7	0.6	0.1	-0.5	-0.5
Medication: Omeprazole	0.3	0.4	1.1	0.3	-0.5	-0.8	-1.1	-0.6	0.4	0.5
Medication: Seretide 50 evohaler	0.1	0.1	0.2	0.2	-0.5	0.1	-0.4	-0.2	-0.3	0.4
Mean time to correctly identify matches	0.7	1.3	3.1	-0.9	-1.4	0.6	-0.9	-1.4	-1.8	-0.8
Heart disease (mother)	0.1	0.1	0.6	0.2	0.3	-0.1	-0.1	0.3	0.8	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	4.3	-1.2	-0.9	2.1	0.7	-0.0	-0.7	-1.5
Whole body fat mass	0.5	1.9	3.7	1.6	-0.3	-1.9	-1.6	-0.9	1.2	1.5
Leg fat mass (right)	0.5	2.1	4.1	1.8	-0.2	-2.0	-1.6	-0.6	1.2	1.8
Arm predicted mass (right)	0.1	0.4	0.8	0.9	-0.2	-0.9	-0.4	-0.3	-0.2	0.8
Pulse rate, automated reading	1.0	3.1	9.9	-0.1	-3.1	0.5	-1.9	-2.7	-0.4	-0.6
Alcohol intake frequency.	0.4	0.8	2.7	0.0	-1.4	0.3	-0.7	-0.7	-1.6	0.0
Comparative height size at age 10	0.5	2.6	4.8	-1.9	-1.2	2.1	1.1	-0.9	-1.5	-2.2
Number of full sisters	0.3	0.4	1.3	-0.2	-0.7	0.4	-0.6	-1.1	0.1	-0.6
Suffer from ‘nerves’	0.6	1.0	1.8	-1.2	-1.3	1.0	-0.3	-0.8	-0.9	-1.1
Overall health rating	1.2	2.5	5.6	-1.2	-2.1	1.3	-0.7	-2.4	-0.8	-1.7
Chest pain or discomfort	0.7	1.0	2.6	0.6	-0.4	-1.4	-1.6	-0.4	0.8	1.2
Had major operations	0.7	0.8	2.3	0.1	-1.1	-0.2	-1.2	-1.5	0.6	-0.3
Age at last live birth	0.8	1.2	2.8	-0.9	-1.1	1.7	0.3	-0.5	-1.0	-1.4
Family relationship satisfaction	0.5	0.6	1.4	-1.2	0.8	0.5	0.9	-0.3	0.3	-1.1
Leg pain on walking	2.3	2.9	6.6	-2.4	0.9	1.8	1.4	-0.5	1.3	-2.6
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.9	-0.2	-0.6	0.2	0.2	0.9	-0.2	0.6
Commuting to job workplace: Car/motor vehicle	3.2	3.6	8.6	2.4	-0.2	-2.7	-1.7	0.9	0.5	2.9
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.3	0.7	-0.8	-0.2	-0.3	0.6	-0.4	1.1
Medication: Aspirin	1.1	1.4	2.8	1.3	-1.1	-1.3	-1.6	-1.7	0.0	0.5
Supplements: Vitamin C	2.3	2.7	4.5	-2.1	1.6	1.5	1.8	1.4	1.6	-1.4
Knee pain experienced in last month	2.2	3.4	7.5	-2.3	-0.4	2.3	1.3	-1.5	-1.5	-2.7
Hypertension (Self-reported)	0.4	1.0	2.1	-1.2	-0.8	0.8	-0.7	-1.1	-0.5	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.2	4.7	2.0	-0.4	-2.1	-1.4	0.2	-0.2	2.2
Illnesses of father: Heart disease	1.3	1.8	3.5	1.8	1.9	-1.8	0.1	0.3	0.9	1.3
Illnesses of siblings: Diabetes	0.6	0.7	2.2	-1.5	-0.2	1.0	0.7	0.3	0.1	-1.1
Smoking status: Previous	0.4	0.7	1.5	-0.6	0.8	0.8	1.1	1.2	0.3	0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	2.5	-1.6	0.6	1.2	1.3	0.7	-0.0	-1.4
Whole body fat-free mass	0.0	0.1	0.4	0.5	-0.1	-0.6	-0.2	-0.4	0.1	0.5
Leg fat-free mass (right)	0.0	0.3	0.7	0.6	0.3	-0.8	-0.2	-0.3	0.7	0.4
Arm fat percentage (left)	0.6	2.3	4.1	1.8	-0.4	-2.0	-1.8	-0.7	1.1	1.8
Average weekly red wine intake	0.1	0.1	0.3	0.3	0.6	-0.4	0.3	0.0	0.4	0.2
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.0	-0.1	0.7	-0.4	0.0	-1.0	-0.3	-0.8
Mood swings	1.0	1.8	2.7	-1.6	-1.2	1.6	0.4	-0.4	-1.6	-1.6
Loneliness, isolation	1.1	1.6	4.9	-0.7	-2.2	0.3	-1.4	-1.6	-0.7	-0.6
Long-standing illness, disability or infirmity	1.6	2.4	6.1	-0.5	-2.5	0.3	-2.0	-2.4	-0.8	-0.3
Ever had bowel cancer screening	0.9	1.0	2.6	0.4	-1.3	-0.5	-1.6	-1.5	-0.0	0.3
Diabetes diagnosed by doctor	0.9	1.4	2.5	0.8	-1.5	-0.9	-1.5	-1.6	-1.1	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.4	-0.7	1.2	0.6	1.1	-0.2	0.2	-1.2
Friendships satisfaction	1.4	1.7	3.6	-1.6	1.2	1.1	1.6	-0.3	0.7	-1.9
Qualifications: nursing, teaching	0.4	0.6	1.9	0.3	1.0	0.3	0.9	1.4	-0.0	0.3
Commuting to job workplace: Walk	1.0	1.1	2.3	-1.2	-0.4	1.5	0.5	-0.1	-1.2	-1.5
Eye problems/disorders: Cataract	1.3	1.5	3.6	0.9	-1.4	-0.9	-1.9	-1.6	-0.6	0.4
Mouth/teeth dental problems: Mouth ulcers	2.2	3.5	5.9	1.9	-2.4	-1.5	-2.4	-1.1	-1.9	1.6
Medication for cholesterol	0.8	1.2	2.9	1.0	1.7	-1.0	0.6	1.2	0.6	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	4.4	-0.7	-2.1	0.8	-0.9	-0.8	-1.2	-0.2
Back pain experienced in last month	0.9	1.3	2.5	-1.5	-0.7	1.2	-0.3	-0.9	1.0	-1.6
Mineral and other dietary supplements	2.1	2.8	6.8	2.6	0.3	-2.6	-1.4	-0.3	-0.2	2.0
Breast cancer (self-reported)	1.3	1.5	3.3	-0.9	-1.2	1.4	-0.1	-1.2	-1.8	-1.1
Asthma (self-reported)	0.9	1.7	2.6	-1.2	1.6	1.0	1.5	1.2	1.6	-0.9
Osteoporosis (self-reported)	0.2	0.2	0.9	-0.1	-0.1	0.6	0.6	1.0	0.1	0.1
Osteoarthritis (self-reported)	0.5	0.6	2.4	-0.4	-0.5	0.8	0.2	-0.7	-1.5	-0.8
Medication: Aspirin	1.1	1.4	3.0	1.1	-1.3	-1.1	-1.6	-1.7	-0.3	0.4
Medication: Gliclazide	0.4	0.5	1.8	-0.2	-0.5	-0.3	-0.9	-0.5	1.4	0.2
Illnesses of father: None of the above (group 1)	0.7	0.9	3.1	-1.1	-1.8	0.5	-1.1	-0.4	0.2	-0.6
Smoking status: Current	0.6	1.0	3.5	1.2	0.8	-1.9	-0.4	-0.4	0.8	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.3	0.0	1.1	0.2	1.2	0.4	0.7	-0.5
Whole body water mass	0.0	0.1	0.3	0.5	-0.1	-0.5	-0.1	-0.3	0.1	0.4
Leg predicted mass (right)	0.1	0.3	0.7	0.6	0.3	-0.9	-0.2	-0.2	0.7	0.5
Arm fat mass (left)	0.5	1.9	3.8	1.7	-0.3	-2.0	-1.6	-0.8	0.9	1.7
Number of self-reported non-cancer illnesses	0.6	1.0	2.1	-1.4	-0.9	1.4	-0.2	-0.7	-0.0	-1.3
Average weekly champagne plus white wine intake	0.8	1.1	2.4	0.5	0.1	-0.6	-0.7	1.5	1.3	1.5
Miserableness	2.2	3.7	9.8	-0.4	-3.1	0.3	-2.2	-2.7	-2.0	-0.5
Guilty feelings	0.3	0.5	1.2	0.2	-0.8	-0.6	-1.1	-0.4	-0.1	0.9
Wears glasses or contact lenses	0.6	0.6	2.2	-0.3	0.6	0.3	-0.0	1.5	1.1	0.7
Ever taken oral contraceptive pill	0.3	0.3	1.4	0.1	1.2	-0.6	0.5	0.4	-0.1	-0.0
Hearing aid user	0.8	0.9	3.1	0.5	-0.7	-1.0	-1.2	-1.8	-0.2	0.2
Mother’s age at death	0.3	0.4	0.9	0.9	-0.6	-0.7	-0.9	-0.4	-0.0	0.5
Financial situation satisfaction	0.2	0.3	0.9	-0.6	0.3	0.4	0.4	0.1	0.9	-0.5
Tinnitus: Yes, now most or all of the time	1.0	1.2	2.6	1.2	0.3	-1.5	-0.8	-0.1	1.6	1.1
Commuting to job workplace: Public transport	0.5	0.6	3.3	0.4	-0.4	-0.0	-0.5	-1.8	-0.7	-0.3
Eye problems/disorders: Glaucoma	2.0	2.3	4.8	-1.8	-0.9	2.0	0.2	-1.5	-0.9	-2.2
Medication: Blood pressure	0.8	1.5	4.0	-1.2	-2.0	0.9	-1.1	-1.4	-0.2	-1.1
Pain type(s) experienced in last month: Hip pain	0.8	0.9	5.9	-0.4	0.7	-0.2	-0.0	0.3	2.4	-0.1
Supplements: Fish oil (including cod liver oil)	2.3	3.0	6.4	-2.5	0.4	2.4	1.8	0.3	0.6	-2.2
High cholesterol (Self-reported)	1.4	2.5	4.1	2.0	-1.4	-1.3	-1.5	-1.4	-2.0	1.2
Medication: Bendroflumethiazide	1.1	1.7	4.4	0.6	-1.6	-0.5	-2.0	-2.1	0.3	0.2
Medication: Paracetamol	0.2	0.3	0.7	-0.6	0.3	0.5	0.4	0.8	0.9	-0.2
Medication: Lisinopril	0.4	0.5	1.3	-0.0	-0.8	0.3	-0.7	-1.1	0.3	-0.8
Medication: Atorvastatin	1.5	1.8	4.3	1.1	-1.7	-0.6	-1.5	-2.1	-1.2	0.4
Illnesses of father: High blood pressure	2.2	2.7	6.0	1.8	1.9	-1.3	1.0	2.4	0.6	1.7
Alcohol drinker status: Never	0.4	0.5	1.6	0.9	-0.5	-0.1	-0.3	-0.4	-1.3	0.3
Ever smoked	0.2	0.3	1.0	-0.0	1.0	-0.6	0.6	0.2	0.2	0.2
Basal metabolic rate	0.1	0.3	0.8	0.8	-0.1	-0.9	-0.4	-0.3	0.3	0.7
Leg fat percentage (left)	0.5	1.7	3.3	1.6	0.0	-1.8	-1.2	-0.2	1.5	1.5
Arm fat-free mass (left)	0.0	0.2	0.5	0.7	-0.2	-0.6	-0.2	-0.3	-0.2	0.6
Number of operations (self-reported)	1.3	1.9	5.2	-0.2	-2.0	0.1	-1.2	-2.3	-1.5	-0.7
Average weekly beer plus cider intake	0.3	0.5	1.3	-1.1	0.2	0.5	0.5	-0.5	-0.3	-1.1
Irritability	0.2	0.4	1.8	-0.2	-0.3	0.7	0.3	0.5	1.3	-0.2
Risk taking	1.3	1.9	3.1	-1.6	1.5	0.9	1.2	1.2	1.8	-1.2
Ever had prostate specific antigen (PSA) test	1.0	1.2	2.9	-1.0	-0.8	0.6	-0.1	-1.7	-1.4	-1.3
Fractured/broken bones in last 5 years	0.1	0.2	0.3	-0.4	0.5	0.4	0.4	0.5	0.3	-0.3
Age started oral contraceptive pill	1.0	1.2	3.0	1.0	-1.1	-0.7	-1.0	-1.7	-1.4	-0.0
Diastolic blood pressure, automated reading	0.1	0.2	0.4	0.5	-0.6	-0.1	-0.7	0.4	-0.2	0.6
Ever depressed for a whole week	0.9	1.2	1.8	-1.1	-1.1	0.7	-0.3	-1.4	-1.2	-1.3
Unable to work because of sickness or disability	0.8	1.0	2.1	-0.6	-1.3	0.6	-0.6	-1.2	-1.5	-0.8
Commuting to job workplace: Cycle	0.1	0.2	0.7	-0.3	0.1	0.1	0.1	0.8	0.5	0.2
Myopia	0.2	0.2	1.3	0.1	0.1	0.2	0.3	-1.2	-0.4	-0.3
Vascular/heart problems diagnosed by doctor	0.5	1.3	2.4	0.8	1.3	-0.7	1.0	1.6	1.3	1.2
Cholesterol lowering medication	1.3	1.9	6.8	0.1	-2.6	0.4	-1.4	-1.6	-1.4	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.3	0.9	-0.5	-1.1	-1.1	-0.9	0.3	0.7
Pain experienced in last month	0.5	0.9	2.7	0.8	0.4	-0.8	-0.1	1.7	-0.1	1.4
Supplements: Calcium	0.7	0.8	1.7	-0.9	0.6	1.1	1.0	1.3	0.8	-0.2
Basal cell carcinoma (self-reported)	1.0	1.1	4.4	0.8	-1.5	0.4	-0.3	-0.5	-2.1	0.3
Heart attack/myocardial infarction (self-reported)	1.6	2.1	3.4	-1.4	-1.3	1.4	-0.0	-1.8	-1.7	-1.7
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	5.1	0.2	-1.4	-0.3	-1.2	-2.3	-1.3	-0.6
Heart disease (siblings)	0.7	0.9	1.8	-1.3	-0.3	1.3	0.7	0.3	-0.8	-1.2
Alcohol drinker status: Previous	0.4	0.4	1.6	-0.4	-0.6	0.2	-0.0	0.7	1.3	0.5
Pack years of smoking	0.4	0.6	1.3	-0.6	-0.1	-0.7	-1.0	-1.0	1.2	-0.3
Impedance of whole body	0.1	0.7	1.5	-0.9	-0.7	1.2	0.5	-0.2	-0.8	-1.1
Leg fat mass (left)	0.4	1.7	3.6	1.6	-0.1	-1.9	-1.4	-0.5	1.1	1.5
Arm predicted mass (left)	0.1	0.5	1.1	1.1	-0.1	-1.1	-0.5	-0.4	-0.1	1.0