Hub : Genes

PARP15

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.1572	0.0458	5.2e-04	0.087	NA	0.101	NA	0.111	6.6e-09	NA	3.7e-10	NA	5.2e-11
2	METSIM	Adipose	0.0569	0.0237	2.5e-03	0.047	0.023	0.045	0.033	0.051	1.1e-07	2.0e-04	2.1e-07	9.1e-06	3.7e-08
3	NTR	Blood	0.3041	0.0331	0.0e+00	0.250	0.220	0.257	0.265	0.260	6.0e-80	2.2e-69	1.4e-82	2.4e-85	1.2e-83
4	YFS	Blood	0.2519	0.0335	0.0e+00	0.074	0.124	0.129	0.132	0.118	4.9e-23	2.8e-38	8.1e-40	4.9e-41	1.8e-36
5	TCGA	Breast Invasive Carcinoma	0.0494	0.0209	8.7e-04	0.010	0.012	0.016	NA	0.015	2.6e-03	1.2e-03	2.7e-04	NA	4.4e-04
6	TCGA	Brain Lower Grade Glioma	0.0880	0.0310	2.2e-05	0.040	0.041	0.032	NA	0.028	2.3e-05	1.8e-05	1.5e-04	NA	3.0e-04
7	TCGA	Thyroid Carcinoma	0.0550	0.0250	2.6e-03	0.025	0.021	0.007	NA	0.014	1.5e-03	3.4e-03	6.2e-02	NA	1.4e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.9	1.4	3.1	-1.1	-1.8	-0.1	-0.8	-1.6	-0.4	-1.5
Bipolar Disorder or Schizophrenia	0.6	1.4	3.1	-1.4	-1.8	-1.1	-1.6	-0.5	-0.5	0.4
Depressed Affect (Nagel 2018)	0.6	1.3	5.5	-0.5	-1.1	2.4	1.2	0.1	-0.3	0.5
Depression (Nagel 2018)	1.4	2.2	4.2	1.2	0.7	1.9	1.6	2.0	1.7	0.2
Intelligence (Savage-Jansen 2018)	0.7	2.1	8.0	-1.1	-1.3	-1.1	-2.8	-0.1	-1.7	0.4
Neuroticism (Nagel 2018)	0.8	1.8	10.2	0.1	-0.5	3.2	0.9	-0.1	0.6	1.1
Schizophrenia (2018)	0.6	1.2	3.0	-0.9	-0.8	-1.3	-1.5	0.3	-0.5	1.7
Schizophrenia vs Biploar Disorder	1.0	1.3	4.1	-0.4	-0.4	-2.0	-1.7	-0.6	-1.0	0.0
Worry (Nagel 2018)	1.1	2.3	7.6	0.9	1.2	2.8	1.4	0.9	0.8	1.6
Alzheimer’s Disease (in mother)	0.8	1.0	4.6	1.0	0.7	-0.6	-0.6	-2.2	-0.2	0.1
Alzheimer’s Disease (in father)	0.8	0.9	2.6	-0.8	-1.4	-0.0	-1.6	-0.5	-0.9	-0.2
Alzheimer’s Disease (including proxy)	0.4	0.6	1.7	1.0	0.1	-0.5	-1.1	-1.3	-0.2	0.4
Crohns Disease (2017)	0.2	0.5	1.3	-0.4	-1.1	0.1	-0.2	-0.1	-1.1	1.0
Irritable Bowel Disease (IBD)	1.3	3.2	5.9	-1.3	-2.4	-0.6	-2.1	-1.8	-2.1	1.5
Ulcerative Colitis (UC)	2.4	4.5	8.8	-1.4	-2.7	-0.7	-3.0	-2.8	-1.7	1.5
Major Depression (MDD)	0.6	0.8	3.2	0.6	0.8	-1.8	0.7	-0.3	0.6	-0.6
Reaction Time	0.2	0.4	1.0	0.9	-0.4	0.0	0.4	1.0	0.5	-0.1
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.3	-1.1	-0.7	0.6	-1.1	-0.4	-0.1	0.2
Breast Cancer	0.9	2.2	6.9	-1.0	-0.9	-1.8	-2.6	-1.1	-1.1	-0.7
Ovarian Cancer	0.4	0.6	2.4	-0.0	0.3	-1.2	-1.6	0.3	0.4	0.3
Prostate Cancer	1.6	2.3	5.2	0.9	0.8	2.2	1.1	2.3	1.8	0.5
Age at First Birth	0.8	1.1	3.0	-0.7	-0.9	-0.2	0.3	-1.7	-1.6	-0.9
Bipolar Disorder (2011)	0.6	0.5	1.5	0.8	0.0	0.7	0.9	1.2	0.1	0.5
Body Mass Index (BMI) (2010)	0.5	0.8	2.0	-0.9	0.3	-1.3	-1.4	-0.8	-0.2	0.1
Coronary Artery Disease (CAD)	0.5	0.7	2.0	-0.6	-1.0	1.0	0.0	-0.3	-1.4	0.5
Crohns Disease (2012)	0.4	0.6	2.8	-0.1	-0.1	1.7	1.0	0.1	0.4	0.3
Mean Putamen Volume	0.9	1.0	4.0	0.8	-0.6	-0.5	-1.2	0.3	0.2	2.0
Fasting Glucose	0.2	0.3	1.0	-0.7	-0.4	0.5	0.1	0.3	-1.0	0.0
HbA1C	0.8	0.9	2.2	0.7	0.9	0.8	-0.3	1.2	0.9	1.5
HDL Cholesterol	0.3	0.6	1.7	-0.0	-0.7	-0.4	-0.4	-1.3	-0.7	-0.9
LDL Cholesterol	1.8	2.8	13.6	0.5	1.0	-1.9	0.3	0.7	0.8	-3.7
Lupus	1.1	1.6	4.0	1.3	0.4	0.8	0.9	1.6	1.3	2.0
Neuroticism (2016)	1.5	2.1	9.7	-0.8	-0.2	1.5	1.1	-0.3	1.1	-3.1
Primary Biliary Cirrhosis	1.5	2.1	8.7	1.1	-0.1	2.0	0.5	-0.1	0.6	3.0
Rheumatoid Arthritis	1.3	1.7	4.3	0.4	-0.9	-1.4	-1.8	-2.1	-0.9	-1.0
Schizophrenia (2014)	0.3	0.7	1.7	-0.7	-0.7	-0.8	-1.2	-0.3	-0.5	1.3
Triglycerides	0.3	0.5	1.6	-0.0	0.6	-1.2	-0.4	-0.0	-0.3	-1.3
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.5	-0.7	-0.6	-0.1	-0.2	0.5	-0.0	-0.7
Ulcerative Colitis	1.2	1.7	3.3	-0.8	-1.8	1.1	-1.5	-1.4	-0.4	1.5
Blood Eosinophil Count	0.1	0.9	3.0	0.3	-0.5	0.4	-1.4	-0.6	0.4	1.7
Blood Platelet Count	0.1	1.4	9.1	-0.3	0.1	0.7	0.3	-0.2	-0.2	-3.0
Blood Red Count	0.3	2.5	7.4	-2.0	-0.6	1.0	1.8	-1.0	0.9	-2.7
Blood White Count	0.0	0.2	0.3	0.6	-0.2	0.0	0.5	-0.5	-0.4	-0.5
Heel T-Score	0.1	0.7	2.3	-0.6	-0.2	-1.1	0.1	0.6	-0.4	-1.5
BMI	0.2	1.0	2.9	-1.7	-1.0	-0.3	-1.0	-0.6	-0.9	0.7
Height	0.3	4.9	12.1	-2.1	-3.5	-0.2	-1.0	-0.8	-3.0	2.7
Waist Hip Ratio (WHR)	0.1	0.3	1.1	0.2	-1.1	0.6	0.3	0.0	0.5	0.2
Systolic Blood Pressure	0.6	2.8	5.9	1.0	2.3	-0.0	1.4	1.0	2.2	-2.4
Smoking Status	0.6	1.5	3.0	0.9	1.4	1.2	0.3	1.6	1.7	1.0
Allergy or Eczema	0.4	1.0	4.1	0.4	-0.0	1.2	0.1	-0.8	1.0	2.0
Cardiovascular Disease	0.2	0.6	1.7	0.1	0.9	-0.7	0.3	0.7	0.5	-1.3
Hypothyroidism (self reported)	0.5	1.2	5.3	1.0	0.8	0.5	0.0	-0.2	0.8	2.3
Respiratory disease	0.1	0.3	1.0	0.4	-0.0	0.2	-1.0	0.3	0.5	0.6
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.1	-1.0	-1.1	0.3	-0.9	0.8	-0.8	-0.3
Lung FEV1/FVC ratio	0.2	1.2	1.7	-1.3	-1.2	-0.3	-1.1	-1.2	-0.9	1.2
Lung FVC	0.4	2.0	3.1	-1.6	-1.3	-1.2	-1.3	-1.8	-1.2	-1.4
Neuroticism	0.5	1.2	6.1	0.2	-0.0	2.5	1.2	-0.1	0.6	0.5
Chronotype (morning person)	0.4	0.9	2.3	-1.5	-0.7	-0.8	-0.6	-0.7	-0.8	-1.4
Hair Pigment	0.7	19.6	44.6	-1.6	-4.7	-5.9	-1.2	-0.8	-5.5	-6.7
Tanning	0.1	0.9	3.8	-0.9	-0.7	2.0	-0.1	-0.3	-0.0	1.0
Hand grip strength (left)	0.8	2.1	4.5	-1.1	-1.0	-1.7	-2.1	-1.9	-1.3	0.6
Number of treatments/medications taken	0.7	1.2	4.5	-0.3	0.1	0.5	0.8	2.1	1.0	-1.3
Average weekly spirits intake	0.3	0.4	2.3	-0.2	-0.7	-0.1	0.4	-0.1	0.0	1.5
Sensitivity / hurt feelings	0.3	0.6	1.5	0.8	-0.2	1.2	0.5	-0.7	1.0	-0.5
Frequency of depressed mood in last 2 weeks	1.6	2.3	4.2	1.3	1.0	2.0	1.9	1.7	1.5	0.3
Hearing difficulty/problems: Yes	2.0	3.0	8.2	2.0	1.5	1.6	0.1	1.6	1.0	2.9
Relative age of first facial hair	1.1	2.2	8.2	0.7	0.2	-2.9	-2.5	0.2	0.2	-0.7
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.7	-0.7	-0.5	0.3	0.3	0.1	-0.9	-0.0
Ever used hormone-replacement therapy (HRT)	0.3	0.4	2.1	-0.2	0.6	0.1	0.3	-0.0	-0.0	-1.5
Ever had hysterectomy (womb removed)	0.8	0.9	2.2	-1.1	-0.2	1.0	1.2	0.3	0.5	-1.5
Systolic blood pressure, automated reading	0.5	1.4	3.0	0.3	1.6	-0.1	0.4	1.2	1.7	-1.5
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	2.8	-1.5	-1.6	1.7	-0.1	-0.8	-0.7	-0.2
Angina	0.8	1.0	5.1	-0.8	-0.3	0.2	1.1	-0.2	-0.3	-2.3
Medication for hormone replacement therapy	0.8	0.9	2.1	1.4	1.3	0.3	0.8	1.0	0.9	0.4
Vitamin and mineral supplements	3.2	4.3	10.2	2.4	3.2	0.2	2.1	2.2	2.1	-0.6
Supplements: Zinc	0.7	0.8	1.9	-1.2	-1.0	-0.8	-0.4	-0.3	-1.4	0.4
Medication: Co-codamol	0.3	0.3	0.9	-0.3	-0.4	-0.7	-0.3	0.6	0.6	-1.0
Medication: Metformin	0.6	0.9	2.6	-1.3	-1.1	0.2	-0.5	0.4	-0.7	-1.6
Diabetes (father)	0.4	0.5	2.4	0.4	0.2	-0.7	-0.3	-1.5	-0.5	-0.3
Diabetes (mother)	0.4	0.5	0.9	0.1	0.5	-0.7	1.0	0.9	-0.7	0.8
Severe depression (siblings)	0.7	0.7	1.8	0.0	-1.0	0.9	-0.1	0.4	-1.1	1.4
Pack years adult smoking proportion	1.8	2.7	10.6	0.9	1.2	3.3	2.0	0.1	0.8	1.0
Impedance of leg (right)	0.1	0.4	2.2	0.1	-0.1	-0.6	-0.5	0.2	-0.2	-1.5
Leg fat-free mass (left)	0.3	1.8	3.9	-1.6	-1.8	0.3	-0.0	-0.9	-1.4	2.0
Trunk fat percentage	0.1	0.3	1.6	-1.2	-0.5	-0.0	0.6	-0.4	-0.2	0.1
Hand grip strength (right)	0.8	2.2	4.4	-1.6	-1.2	-0.6	-1.4	-2.1	-1.7	1.3
Townsend deprivation index at recruitment	0.3	0.4	1.2	1.1	0.2	0.6	-0.0	1.0	0.2	0.7
Current tobacco smoking	0.4	0.7	3.6	0.2	0.1	0.5	-0.0	0.9	-0.4	1.9
Average weekly fortified wine intake	0.5	0.5	2.5	-0.5	-0.0	0.5	1.6	-0.9	-0.3	-0.0
Maternal smoking around birth	0.2	0.4	0.8	0.6	0.8	-0.9	-0.5	0.3	0.5	0.3
Fed-up feelings	0.8	1.4	3.9	0.7	0.2	1.9	2.0	1.0	0.7	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	4.9	0.3	-0.6	2.2	0.7	2.2	0.6	0.2
Relative age voice broke	1.2	1.9	4.7	2.2	1.6	-1.0	-0.5	1.7	1.2	0.4
Taking other prescription medications	0.6	1.0	1.9	0.3	0.8	1.2	1.4	1.2	1.0	0.4
Age when periods started (menarche)	0.3	0.7	1.7	1.3	1.1	-0.8	0.1	0.5	0.9	0.2
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	5.3	-0.9	-0.4	-0.5	-0.3	-0.3	-0.6	-2.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	2.4	-0.6	0.1	-0.5	-0.3	-0.7	0.1	-1.5
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	5.0	0.6	-0.3	1.5	1.5	1.1	0.1	2.2
Qualifications: CSEs or equivalent	1.1	1.4	3.8	2.0	1.2	0.2	0.4	1.5	1.4	-0.1
Serious illness, injury or assault to yourself	0.5	0.7	2.4	0.0	0.4	1.4	1.5	0.2	0.3	0.3
High blood pressure	0.3	0.9	2.2	0.2	1.1	-0.8	0.7	1.2	0.5	-1.5
Hayfever, allergic rhinitis or eczema	0.6	1.3	6.1	0.7	0.4	0.9	-0.0	-0.5	1.2	2.5
Multivitamins +/- minerals	1.6	2.1	4.2	-1.5	-2.0	-1.0	-0.9	-1.7	-1.7	0.6
Stomach or abdominal pain in last month	0.3	0.4	1.5	1.2	0.6	0.1	0.4	0.3	0.5	0.6
Supplements: Glucosamine	0.5	0.7	3.2	-1.8	0.0	-0.6	0.5	0.2	-0.8	-0.7
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	2.5	0.1	-0.2	-0.3	-1.6	-0.1	0.0	-0.5
Medication: Atenolol	0.4	0.5	1.0	0.8	0.5	-1.0	0.3	0.6	0.6	-0.9
Medication: Levothyroxine sodium	0.7	1.2	4.3	0.6	1.2	0.6	0.9	-0.0	1.1	2.1
Sitting height	0.1	0.8	1.8	-1.3	-1.2	0.4	0.0	-0.5	-0.9	1.1
Chronic bronchitis/emphysema (father)	0.2	0.2	1.2	-1.1	-0.0	0.5	0.4	-0.0	0.3	-0.1
High blood pressure (mother)	0.8	1.1	3.0	1.4	0.4	-1.7	-0.8	0.0	-0.3	1.2
Body mass index (BMI)	0.1	0.4	0.9	-1.0	-0.2	0.7	0.6	-0.2	0.4	1.0
Impedance of leg (left)	0.1	0.4	2.1	0.4	0.1	-0.3	-0.4	0.5	0.4	-1.5
Leg predicted mass (left)	0.3	1.8	3.6	-1.6	-1.9	0.2	-0.1	-0.9	-1.5	1.9
Trunk fat mass	0.1	0.5	2.1	-1.4	-0.7	0.0	0.6	-0.5	-0.4	0.5
Waist circumference	0.1	0.4	1.4	-1.2	-0.8	0.4	0.4	0.0	-0.1	0.7
Number of incorrect matches in round	2.1	3.5	5.6	2.4	2.1	0.3	2.3	2.4	1.6	0.8
Past tobacco smoking	0.2	0.4	1.0	0.4	0.4	-1.0	0.8	-0.6	-0.7	-0.3
Alcohol usually taken with meals	0.6	0.9	3.2	-1.8	-1.2	0.0	-0.6	-0.8	-0.8	0.0
Nervous feelings	0.7	1.3	2.2	1.2	1.5	0.7	1.4	1.2	1.1	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.9	0.8	0.2	0.9	0.2	0.8	0.5	-0.7
Hearing difficulty/problems with background noise	0.4	0.7	2.2	1.5	0.9	-0.2	-0.6	0.1	0.2	1.2
Hair/balding pattern: Pattern 2	0.6	0.7	1.5	0.1	0.4	1.0	1.2	1.2	0.3	-1.0
Had menopause	0.3	0.3	1.4	-1.2	0.5	-0.1	0.4	0.1	0.3	-0.6
Had other major operations	1.4	1.7	5.1	1.0	1.6	-0.5	1.4	2.2	0.8	-0.5
Forced vital capacity (FVC)	0.2	0.8	2.7	-0.3	-1.3	-0.3	-0.4	-0.6	-1.7	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	2.2	-0.4	0.1	-0.3	0.4	-1.0	-0.0	-1.5
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	3.2	-0.6	-0.9	0.7	-0.2	-1.8	-0.6	-0.8
Qualifications: None of the above	0.6	1.2	4.2	-0.4	-0.2	1.2	0.9	1.1	0.6	-2.1
Financial difficulties in last 2 years	0.3	0.4	0.8	-0.3	0.4	0.9	0.8	0.8	0.2	0.2
Mouth/teeth dental problems	0.3	0.4	1.3	0.7	0.9	-0.4	0.1	-1.1	-0.0	0.1
Heart attack	2.3	3.0	7.3	1.5	1.6	0.9	2.7	1.6	2.2	-0.8
Allergy	0.7	1.5	5.7	-0.7	-1.0	-1.0	-0.1	0.2	-1.6	-2.4
Pain all over the body in last month	0.9	0.9	3.7	0.7	0.4	-1.9	-1.3	-0.1	-0.6	0.2
Diabetes (self-reported)	0.7	1.1	5.5	-1.1	-0.7	-0.3	-0.5	0.7	-0.3	-2.3
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	2.4	-0.0	-0.4	1.6	0.5	-0.4	-0.2	0.9
Medication: Ramipril	1.0	1.3	2.6	1.3	1.2	-1.1	0.6	0.8	1.0	-1.6
Medication: Simvastatin	1.7	2.6	5.4	0.1	0.8	2.0	1.8	1.6	1.4	-2.3
Fluid intelligence score	0.2	0.4	1.3	-0.5	-0.3	1.1	-0.6	0.7	-0.2	0.1
Illnesses of siblings	0.3	0.4	1.0	-0.6	-0.5	0.9	0.0	-1.0	-0.5	-0.1
Neuroticism score	0.3	0.6	3.1	-0.5	-0.6	1.8	0.6	0.1	-0.2	-0.3
Weight	0.2	1.2	3.2	-1.8	-1.4	0.4	0.4	-0.5	-0.8	1.4
Impedance of arm (right)	0.1	0.3	1.3	0.4	-0.1	-0.6	-0.3	0.4	-0.4	-1.1
Arm fat percentage (right)	0.1	0.3	1.6	-1.2	-0.3	-0.1	0.4	-0.3	0.1	-0.2
Trunk fat-free mass	0.3	1.8	3.5	-1.8	-1.9	0.2	-0.2	-1.0	-1.5	1.5
Hip circumference	0.1	0.5	1.3	-1.1	-0.9	-0.4	-0.1	-0.6	-0.6	0.7
Time employed in main current job	1.8	2.1	8.1	-1.1	-0.8	2.9	0.3	-0.5	0.6	2.0
Alcohol intake versus 10 years previously	0.4	0.5	1.3	0.4	-0.1	1.1	0.5	0.7	-0.4	1.1
Father’s age at death	1.1	1.5	2.9	-1.7	-1.7	-0.7	0.2	-0.5	-1.7	-1.1
Worrier / anxious feelings	0.5	1.0	4.4	0.7	0.4	2.1	-0.1	0.3	1.3	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.6	1.1	1.0	-0.3	1.0	0.1	1.0	-0.4	0.7
Falls in the last year	0.8	1.0	3.1	-0.8	-0.6	0.8	-0.4	0.3	-1.6	1.8
Hair/balding pattern: Pattern 3	1.9	2.8	6.8	1.3	2.6	1.0	2.2	1.2	2.0	-0.2
Number of live births	1.5	2.1	6.7	0.9	1.2	1.6	2.6	-0.1	0.8	-1.7
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	3.9	-0.8	-1.9	-0.4	-1.1	-1.2	-2.0	0.8
Pulse rate	0.9	1.5	4.7	-0.5	-2.0	0.2	0.1	0.8	-1.2	2.2
Happiness	2.5	3.1	8.6	0.6	0.5	2.5	1.3	0.5	2.0	2.9
Noisy workplace	0.5	0.6	1.5	1.2	0.4	-1.1	-0.3	1.0	0.4	0.5
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.6	-0.2	-0.3	-0.0	-0.0	0.5	-0.3	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	3.5	-0.8	-0.9	0.0	-1.3	-0.6	-1.9	0.1
Mouth/teeth dental problems: Dentures	0.5	0.9	2.4	-1.4	-1.6	1.1	-0.4	-0.4	-0.4	0.6
Asthma	0.2	0.3	1.0	0.0	0.4	0.4	-0.6	0.5	1.0	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.1	2.0	-1.4	-1.4	0.8	-0.4	-0.8	-0.6	-1.3
Medication: Cholesterol lowering	1.9	3.0	13.3	0.8	1.8	0.2	1.0	0.7	1.5	-3.7
Depression (self-reported)	0.2	0.2	0.7	0.3	-0.6	0.0	0.0	0.3	-0.5	-0.8
Medication: Lansoprazole	0.5	0.6	2.5	1.1	0.2	0.1	-0.0	1.6	0.3	-0.0
Prospective memory result	0.4	0.5	2.2	0.6	-0.6	-0.2	0.1	-0.8	-1.5	0.5
Lung cancer (father)	1.3	1.5	5.1	0.6	0.6	1.6	2.3	0.9	0.2	1.3
Illnesses of mother	1.1	1.4	2.7	0.9	0.6	1.7	1.2	1.1	1.7	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	3.5	-0.8	-1.5	-1.0	-1.3	-0.6	-1.9	1.2
Pulse wave Arterial Stiffness index	0.3	0.4	1.1	-1.0	-0.0	-0.1	0.1	-0.6	-0.8	0.6
Impedance of arm (left)	0.1	0.6	1.6	0.2	-0.5	-0.8	-0.5	0.0	-1.1	-1.3
Arm fat mass (right)	0.1	0.5	2.0	-1.4	-0.7	0.1	0.6	-0.3	-0.4	0.3
Trunk predicted mass	0.3	1.8	3.7	-1.9	-1.9	0.2	-0.2	-0.9	-1.5	1.5
Standing height	0.3	2.9	6.9	-2.1	-2.6	-0.4	-0.3	-0.9	-2.6	1.0
Length of working week for main job	1.0	1.1	2.3	-1.0	-1.4	0.7	-1.5	-0.8	-0.9	0.6
Exposure to tobacco smoke at home	1.5	1.7	3.5	1.7	1.5	0.9	0.4	-0.7	1.9	1.3
Breastfed as a baby	0.3	0.4	0.9	-0.6	-0.4	-0.9	-0.7	0.2	-0.3	-1.0
Tense / ‘highly strung’	1.0	1.6	4.2	1.4	0.9	2.1	1.3	1.3	0.6	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.3	5.5	-0.8	-0.8	-0.4	-0.7	0.5	-1.1	-2.3
Hair/balding pattern: Pattern 4	0.3	0.8	1.9	1.0	1.4	0.1	0.6	0.8	1.4	0.3
Birth weight of first child	0.6	1.1	2.3	-0.0	-0.0	1.3	1.3	-1.4	-0.2	1.5
Peak expiratory flow (PEF)	0.7	1.5	3.1	-0.4	-1.2	-0.3	-1.2	-1.7	-1.6	1.4
Pulse wave reflection index	0.3	0.4	1.4	-0.1	1.2	0.3	0.4	-1.0	-0.1	0.3
Ever highly irritable/argumentative for 2 days	0.2	0.2	1.1	0.6	-0.0	0.3	-0.1	-0.1	-0.3	1.0
Loud music exposure frequency	0.9	0.9	4.9	-0.0	-0.8	0.6	-0.5	0.6	0.4	2.2
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	7.3	0.6	-0.0	0.0	-0.4	0.2	0.2	2.7
Mouth/teeth dental problems: Bleeding gums	1.4	1.9	2.9	0.0	0.9	1.6	1.5	1.7	1.3	1.7
Blood clot in the leg (DVT)	0.2	0.3	1.0	0.2	-0.4	-0.3	-0.8	-1.0	-0.4	-0.0
Medication: Paracetamol	0.3	0.5	1.6	0.2	0.4	-1.3	-0.4	0.7	-0.4	-1.0
Headache pain in last month	0.2	0.4	1.7	-0.1	-1.3	-0.2	0.3	-0.2	-1.0	-0.1
Medication for cholesterol, blood pressure or diabetes	1.9	3.2	5.4	-1.1	-2.1	-0.6	-1.9	-2.1	-2.3	1.6
Glaucoma (self-reported)	0.2	0.3	0.7	0.5	0.7	0.2	0.6	0.2	0.1	0.9
Gout (self-reported)	0.2	0.3	0.9	-0.9	-0.4	-0.6	-0.5	-0.2	-0.7	-0.4
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	5.7	0.8	0.8	0.9	0.9	-0.4	0.8	2.4
Medication: Amlodipine	1.0	1.4	4.2	0.6	1.1	-1.6	0.5	2.0	0.7	-0.8
Medication: Ventolin 100micrograms inhaler	0.7	0.8	1.5	-0.7	-1.2	1.2	-0.6	0.7	-0.6	1.1
Birth weight	0.3	0.6	1.8	0.7	1.4	-0.6	0.3	0.8	0.7	0.7
Chronic bronchitis/emphysema (mother)	0.3	0.3	1.1	-0.2	-1.0	0.0	-0.4	0.1	-1.1	-0.1
High blood pressure (siblings)	0.3	0.4	2.1	0.5	0.1	-0.3	-0.3	0.0	-0.1	1.4
Forced vital capacity (FVC), Best measure	0.4	1.5	4.2	-0.7	-1.4	-1.0	-1.0	-0.7	-2.1	1.2
Body fat percentage	0.1	0.3	1.5	-1.2	-0.4	0.1	0.5	-0.3	-0.0	0.0
Leg fat percentage (right)	0.2	0.6	3.3	-1.8	-0.7	-0.2	0.1	-0.2	0.2	-0.6
Arm fat-free mass (right)	0.4	2.1	3.9	-2.0	-2.0	0.1	-0.1	-1.0	-1.6	1.7
Exposure to tobacco smoke outside home	0.1	0.1	0.4	-0.6	-0.4	0.1	-0.1	-0.2	0.4	0.0
Comparative body size at age 10	0.1	0.2	0.5	-0.2	0.7	0.7	0.2	0.3	0.2	0.3
Number of full brothers	1.0	1.3	2.6	1.4	0.7	1.1	0.6	1.3	0.8	1.6
Worry too long after embarrassment	0.8	1.4	5.6	-0.2	-0.9	2.4	0.3	-0.9	0.7	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.1	-0.5	-0.9	-0.8	-1.0	0.5	-1.5	-0.5
Wheeze or whistling in the chest in last year	0.8	1.5	4.3	-0.0	-0.8	2.1	0.9	0.2	0.8	2.0
Number of children fathered	0.8	0.9	2.1	0.6	1.1	-0.1	-0.7	1.4	1.5	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	1.9	0.9	1.4	-0.8	0.5	0.7	1.3	0.5
Age at first live birth	0.3	0.5	1.5	0.4	0.2	-1.2	0.6	0.7	-0.5	0.9
Pulse wave peak to peak time	0.2	0.2	0.7	0.8	-0.2	-0.1	-0.4	0.6	0.5	-0.5
Health satisfaction	0.4	0.6	1.1	0.9	0.2	0.8	-0.4	-1.0	0.7	0.9
Shortness of breath walking on level ground	0.6	0.7	2.3	1.1	0.5	-0.4	0.0	0.0	-1.1	1.5
Qualifications: College or University degree	0.2	0.6	3.2	0.7	0.1	0.5	0.4	0.1	-0.6	1.8
Eye problems/disorders: None of the above	0.8	1.0	4.7	-0.5	-0.6	-0.9	-2.2	-0.5	-0.5	0.4
Mouth/teeth dental problems: Loose teeth	1.3	1.5	3.3	-0.0	1.0	1.8	1.3	1.1	1.3	-1.4
Emphysema/chronic bronchitis	0.3	0.3	1.0	-0.1	-0.5	-0.7	-0.6	0.0	-1.0	-0.4
Medication for pain relief, constipation, heartburn	0.9	1.6	4.7	1.3	1.3	0.8	0.7	-0.3	1.3	2.2
Neck or shoulder pain in last month	0.2	0.3	0.6	-0.8	-0.7	0.2	-0.7	0.5	-0.4	0.0
Medication: Blood pressure	1.5	2.7	5.7	1.0	1.9	0.2	2.0	2.0	2.4	-0.4
Angina (self-reported)	0.9	1.2	5.6	-0.9	-0.4	0.4	1.3	-0.5	-0.3	-2.4
Migraine (self-reported)	1.3	1.6	3.7	0.6	1.0	1.9	1.9	0.1	1.6	0.1
Medication: Ibuprofen	0.6	0.7	1.3	-1.0	-1.0	1.1	0.2	-0.6	-0.2	-1.0
Medication: Allopurinol	0.2	0.2	1.1	-0.0	0.1	-0.2	-0.1	1.1	0.6	-0.0
Medication: Omeprazole	0.1	0.1	0.6	0.2	-0.0	-0.3	-0.2	0.1	0.1	-0.8
Medication: Seretide 50 evohaler	0.2	0.2	0.7	0.8	0.3	0.1	-0.1	0.5	0.5	0.5
Mean time to correctly identify matches	0.2	0.3	1.2	-0.3	-0.7	-0.2	0.2	0.6	0.3	-1.1
Heart disease (mother)	0.4	0.5	1.8	-1.3	-0.3	-0.1	-0.3	-0.5	-1.0	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	3.5	-0.4	0.3	-0.6	0.9	1.9	1.4	-1.3
Whole body fat mass	0.1	0.6	2.0	-1.4	-0.8	0.3	0.7	-0.5	-0.4	0.6
Leg fat mass (right)	0.1	0.5	2.2	-1.5	-0.7	0.2	0.7	-0.3	-0.0	0.5
Arm predicted mass (right)	0.4	2.2	4.8	-2.2	-2.0	0.1	-0.2	-1.3	-1.8	1.3
Pulse rate, automated reading	0.3	1.1	2.9	-0.9	-1.7	0.4	0.1	0.9	-1.0	1.4
Alcohol intake frequency.	0.4	1.0	2.6	-0.9	-1.6	0.8	1.0	-0.4	-1.4	0.2
Comparative height size at age 10	0.4	2.4	5.0	-1.8	-2.2	0.5	0.2	0.2	-1.8	2.1
Number of full sisters	0.2	0.2	0.7	0.1	-0.6	0.4	-0.1	0.5	-0.2	-0.8
Suffer from ‘nerves’	0.2	0.3	1.7	-0.3	0.1	-0.0	-0.2	0.3	-1.3	-0.6
Overall health rating	1.8	3.8	6.2	2.3	1.8	1.3	2.1	2.5	2.1	1.3
Chest pain or discomfort	0.1	0.2	0.4	-0.1	0.5	-0.5	0.4	0.3	-0.2	-0.7
Had major operations	0.8	0.9	2.7	0.9	1.0	0.8	1.6	-0.5	0.6	0.9
Age at last live birth	0.5	0.7	2.8	-0.0	-0.8	-1.1	-0.2	0.1	-1.7	-0.6
Family relationship satisfaction	3.0	3.7	11.3	0.7	1.3	3.4	2.2	0.6	2.2	1.6
Leg pain on walking	0.3	0.4	2.0	0.3	0.2	0.6	0.1	0.5	0.0	1.4
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.5	0.7	-0.5	-0.0	-0.2	0.2	0.6	0.4
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.6	-0.0	0.6	-0.1	0.8	0.6	1.3	-0.8
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.7	-0.7	-1.2	-0.2	-0.4	-1.3	-0.2	-0.5
Medication: Aspirin	0.8	1.0	3.2	-1.1	-0.3	-1.1	0.2	0.2	-1.1	-1.8
Supplements: Vitamin C	2.2	2.6	3.8	-1.8	-1.9	1.4	-1.3	-1.8	-1.6	1.4
Knee pain experienced in last month	0.7	1.1	4.3	-0.8	-0.0	2.1	0.5	1.0	1.3	0.6
Hypertension (Self-reported)	0.4	1.0	3.1	0.0	0.9	-0.6	0.7	1.4	0.6	-1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.2	1.1	0.4	-0.3	0.5	0.2	-0.4	0.9
Illnesses of father: Heart disease	3.2	4.4	7.6	-2.5	-1.8	-2.3	-2.8	-1.7	-1.8	-1.5
Illnesses of siblings: Diabetes	0.6	0.7	1.5	0.2	-0.4	-1.1	-1.0	-0.5	-1.2	-0.9
Smoking status: Previous	0.2	0.3	1.3	0.1	0.4	0.2	-0.1	0.7	1.1	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	2.2	-1.0	-1.5	1.1	0.0	0.3	-0.8	1.3
Whole body fat-free mass	0.3	1.9	3.7	-1.7	-1.9	0.3	-0.1	-0.9	-1.5	1.9
Leg fat-free mass (right)	0.3	1.6	4.5	-1.4	-1.7	0.4	-0.0	-0.7	-1.2	2.1
Arm fat percentage (left)	0.1	0.4	1.9	-1.4	-0.5	-0.1	0.4	-0.5	-0.3	-0.2
Average weekly red wine intake	0.3	0.4	0.7	-0.7	-0.2	-0.6	-0.9	-0.8	0.5	-0.6
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.7	-0.1	0.2	0.7	0.1	0.7	0.8	-1.3
Mood swings	0.4	0.7	2.0	-0.5	-1.2	0.6	0.1	1.4	-0.3	-0.7
Loneliness, isolation	1.7	2.4	5.3	0.2	0.3	2.3	1.9	1.7	0.8	2.0
Long-standing illness, disability or infirmity	0.6	1.0	3.5	0.3	-0.2	0.8	0.8	1.9	0.1	1.4
Ever had bowel cancer screening	0.5	0.6	1.8	0.8	0.3	0.4	0.6	0.7	-0.8	1.4
Diabetes diagnosed by doctor	0.6	1.0	4.6	-1.1	-0.8	0.1	-0.4	0.6	-0.3	-2.1
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.2	0.3	-0.5	-0.3	0.5	0.3	-0.4	-0.4	0.3
Friendships satisfaction	4.3	5.3	8.0	2.0	2.0	2.7	2.8	1.3	2.4	2.6
Qualifications: nursing, teaching	1.6	2.4	4.6	-1.4	-1.1	-1.9	-1.7	-1.4	-2.1	0.8
Commuting to job workplace: Walk	0.7	0.7	2.2	0.8	-0.1	-1.2	-0.6	-0.3	-1.5	0.4
Eye problems/disorders: Cataract	0.9	1.1	2.6	0.4	0.9	1.6	1.2	0.9	1.3	-0.1
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	7.8	0.1	-0.6	-2.8	-1.5	-0.3	-1.2	-1.2
Medication for cholesterol	0.5	0.7	2.0	-0.0	-0.2	-1.1	-1.0	-1.4	-0.6	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.7	0.7	0.7	0.7	1.1	1.6	0.3	-0.2
Back pain experienced in last month	0.3	0.4	1.7	0.1	-0.7	-0.2	-0.1	-0.5	-1.3	-0.4
Mineral and other dietary supplements	0.8	1.0	2.8	1.7	1.4	0.6	1.0	-0.0	0.9	-0.5
Breast cancer (self-reported)	0.6	0.7	1.7	1.3	0.8	-0.8	1.0	1.0	-0.4	-0.0
Asthma (self-reported)	0.1	0.3	0.8	-0.0	0.3	0.4	-0.7	0.3	0.9	0.6
Osteoporosis (self-reported)	0.2	0.2	1.1	0.5	-0.3	-0.1	-0.5	0.3	0.1	1.0
Osteoarthritis (self-reported)	0.6	0.8	1.6	-1.2	-0.9	-0.7	-0.7	-0.1	-0.9	-1.1
Medication: Aspirin	0.5	0.7	2.8	-0.8	-0.2	-0.4	0.9	0.1	-0.6	-1.7
Medication: Gliclazide	0.5	0.6	2.6	-0.6	-0.4	1.6	-0.0	0.6	0.2	-0.9
Illnesses of father: None of the above (group 1)	2.2	2.7	6.3	2.5	1.0	1.3	1.8	2.0	0.7	1.5
Smoking status: Current	0.5	0.7	3.7	0.0	-0.1	0.6	-0.4	0.9	-0.3	1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.8	2.9	-1.2	-1.2	-1.2	-1.7	-1.6	-1.5	-0.4
Whole body water mass	0.3	1.9	3.8	-1.7	-1.9	0.4	-0.1	-0.8	-1.4	2.0
Leg predicted mass (right)	0.3	1.5	4.5	-1.4	-1.6	0.5	0.1	-0.7	-1.1	2.1
Arm fat mass (left)	0.2	0.7	2.9	-1.7	-0.8	0.5	0.7	-0.4	-0.5	0.5
Number of self-reported non-cancer illnesses	0.6	1.1	2.8	-1.4	-1.5	1.7	0.0	0.5	-0.6	-0.2
Average weekly champagne plus white wine intake	0.5	0.7	1.8	-0.6	-0.8	-0.1	-0.9	-1.0	-1.3	0.3
Miserableness	0.6	1.0	4.5	-0.3	-0.8	2.1	0.9	0.4	-0.1	-1.1
Guilty feelings	0.8	1.3	2.0	-1.4	-1.3	1.1	-0.3	-1.2	-1.3	0.7
Wears glasses or contact lenses	0.6	0.7	1.3	-1.0	-0.9	0.9	0.2	-0.8	-1.1	-0.4
Ever taken oral contraceptive pill	0.5	0.5	3.6	0.1	0.2	-0.1	0.1	-0.0	0.2	1.9
Hearing aid user	0.9	1.0	3.1	0.3	-0.2	1.8	-0.5	0.3	0.2	1.8
Mother’s age at death	0.7	0.8	1.6	-1.3	-0.9	0.7	-0.0	-1.2	-1.1	-0.6
Financial situation satisfaction	1.2	1.5	5.7	0.6	0.8	1.1	1.1	1.0	0.7	2.4
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.5	0.5	-0.2	0.3	-0.7	0.2	0.0	0.5
Commuting to job workplace: Public transport	1.2	1.4	3.4	0.1	-1.4	-0.7	-1.8	-0.6	-1.7	0.8
Eye problems/disorders: Glaucoma	0.6	0.8	2.0	0.9	1.3	0.2	1.4	0.7	0.3	0.5
Medication: Blood pressure	0.3	0.6	2.0	0.1	0.7	0.5	1.4	1.1	0.3	-0.1
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.8	-0.2	0.1	0.3	0.2	1.0	-0.2	1.4
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.4	-0.3	-0.3	-0.5	-0.4	0.5	0.3	0.7
High cholesterol (Self-reported)	1.2	2.2	13.4	-0.8	-0.1	0.3	0.5	0.9	0.5	-3.7
Medication: Bendroflumethiazide	0.2	0.2	0.7	-0.8	-0.5	-0.1	0.3	-0.0	-0.7	-0.3
Medication: Paracetamol	0.3	0.4	1.3	0.0	0.1	-1.2	-0.3	0.5	-0.7	-0.8
Medication: Lisinopril	0.6	0.8	2.0	0.2	0.4	0.7	1.0	1.4	0.3	-1.3
Medication: Atorvastatin	0.8	0.9	3.3	-1.1	-0.6	-1.0	-0.0	-0.5	-0.8	-1.8
Illnesses of father: High blood pressure	0.9	1.1	2.6	-0.7	-0.2	-1.4	-1.6	-0.6	-0.8	-1.3
Alcohol drinker status: Never	0.4	0.4	1.8	0.1	0.6	-1.4	0.2	0.6	0.1	-0.7
Ever smoked	0.2	0.4	1.2	-0.4	-0.7	1.1	-0.8	0.4	-0.0	0.6
Basal metabolic rate	0.3	1.8	3.4	-1.7	-1.8	0.5	0.1	-0.8	-1.3	1.9
Leg fat percentage (left)	0.1	0.5	2.5	-1.6	-0.5	-0.1	0.2	-0.2	0.5	-0.6
Arm fat-free mass (left)	0.4	2.2	4.8	-2.2	-2.2	0.3	-0.2	-0.9	-1.6	1.6
Number of operations (self-reported)	0.2	0.3	1.1	0.6	0.8	-0.2	1.0	0.0	-0.1	-0.4
Average weekly beer plus cider intake	2.6	3.7	5.4	2.3	1.8	2.2	1.6	1.5	2.2	1.6
Irritability	0.3	0.5	1.4	0.5	-0.7	1.2	-0.1	0.6	0.9	0.5
Risk taking	0.9	1.3	4.1	-1.5	-0.9	0.1	-1.2	-0.5	-2.0	-0.3
Ever had prostate specific antigen (PSA) test	1.8	2.0	5.0	-2.2	-2.0	-0.1	-1.6	-0.2	-1.6	0.4
Fractured/broken bones in last 5 years	0.4	0.5	2.2	-0.8	-0.5	1.5	-0.4	-0.2	-0.0	0.3
Age started oral contraceptive pill	1.6	2.0	4.8	-0.8	-0.2	-2.2	-0.9	-1.5	-1.9	-1.3
Diastolic blood pressure, automated reading	0.3	0.9	2.1	0.4	1.4	-0.6	0.3	1.5	0.8	-1.0
Ever depressed for a whole week	1.2	1.4	2.7	-1.3	-1.6	0.9	0.1	-1.5	-1.7	-0.2
Unable to work because of sickness or disability	1.4	1.8	8.6	0.9	0.8	0.7	1.0	2.9	0.7	0.9
Commuting to job workplace: Cycle	1.7	2.1	5.0	-1.1	-1.7	-0.6	-1.8	-0.0	-2.2	1.5
Myopia	0.2	0.3	1.5	-0.2	-0.2	1.2	0.2	-0.2	0.4	0.6
Vascular/heart problems diagnosed by doctor	0.5	1.4	3.8	-0.2	-1.1	0.8	-1.0	-1.6	-0.6	2.0
Cholesterol lowering medication	0.9	1.4	3.0	-1.6	-1.5	1.2	0.3	0.6	-0.1	-1.7
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.5	-0.3	-0.6	-0.3	-0.7	0.2	-0.6	-0.2
Pain experienced in last month	0.3	0.4	0.8	-0.9	-0.3	-0.9	-0.5	-0.8	-0.5	-0.4
Supplements: Calcium	1.9	2.1	5.1	-0.7	-1.4	1.0	-1.2	-2.0	-0.9	2.3
Basal cell carcinoma (self-reported)	1.1	1.4	3.1	1.8	1.6	0.1	1.1	0.9	1.3	0.1
Heart attack/myocardial infarction (self-reported)	2.8	3.6	9.3	1.4	1.8	1.2	3.1	1.5	2.4	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.7	0.4	-0.2	-0.3	-0.7	-0.8	-0.1	0.2
Heart disease (siblings)	0.7	0.9	2.8	-0.3	0.0	-1.5	0.2	1.1	-0.1	-1.7
Alcohol drinker status: Previous	0.7	0.8	1.9	-0.5	-1.4	1.3	-0.5	0.2	-0.2	1.1
Pack years of smoking	1.5	2.2	8.7	0.7	1.3	3.0	2.0	-0.2	0.8	0.5
Impedance of whole body	0.1	0.4	1.8	0.4	-0.2	-0.7	-0.5	0.1	-0.4	-1.4
Leg fat mass (left)	0.1	0.6	2.5	-1.6	-0.8	0.2	0.6	-0.5	0.0	0.4
Arm predicted mass (left)	0.4	2.1	4.2	-2.1	-2.0	0.2	-0.3	-1.0	-1.5	1.6