Hub : Genes

LOC100129550

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0850 0.0230 2.2e-07 0.101 0.052 0.075 0.065 0.091 2.8e-12 6.2e-07 1.9e-09 2.1e-08 3.8e-11
2 TCGA Brain Lower Grade Glioma 0.0275 0.0143 1.6e-03 0.022 0.031 0.025 NA 0.023 1.4e-03 1.7e-04 7.2e-04 NA 1.1e-03
3 TCGA Prostate Adenocarcinoma 0.0394 0.0236 5.4e-03 0.013 0.006 0.002 NA 0.001 1.4e-02 6.5e-02 1.6e-01 NA 2.7e-01
4 TCGA Thyroid Carcinoma 0.0810 0.0360 2.1e-03 0.029 0.022 0.010 NA 0.014 6.9e-04 3.0e-03 3.2e-02 NA 1.3e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.4 0.6 1.2 0.3 -0.3 -1.0 1.1
Bipolar Disorder or Schizophrenia 0.7 1.8 4.3 -1.4 -2.1 0.9 0.1
Depressed Affect (Nagel 2018) 3.9 8.1 17.7 3.4 4.2 -1.7 0.4
Depression (Nagel 2018) 0.8 1.2 2.6 1.2 1.6 -0.5 -0.5
Intelligence (Savage-Jansen 2018) 0.1 0.4 0.8 -0.9 -0.4 0.2 -0.8
Neuroticism (Nagel 2018) 1.3 3.0 7.6 1.6 2.8 -0.3 -1.3
Schizophrenia (2018) 1.7 3.6 6.0 -2.0 -2.4 1.9 -0.8
Schizophrenia vs Biploar Disorder 1.4 1.9 3.1 -1.8 -1.4 1.3 -0.9
Worry (Nagel 2018) 0.7 1.5 3.2 0.7 1.8 0.3 -1.5
Alzheimer’s Disease (in mother) 2.0 2.3 5.7 -1.1 -0.1 1.5 -2.4
Alzheimer’s Disease (in father) 0.4 0.4 0.8 0.6 0.7 -0.9 0.1
Alzheimer’s Disease (including proxy) 0.8 1.1 3.5 -0.0 0.8 0.6 -1.9
Crohns Disease (2017) 0.8 1.7 3.1 1.4 0.9 -0.9 1.8
Irritable Bowel Disease (IBD) 0.1 0.2 0.3 -0.3 -0.6 -0.1 0.6
Ulcerative Colitis (UC) 1.0 1.9 3.3 -1.8 -1.8 0.5 -0.9
Major Depression (MDD) 0.3 0.4 0.9 0.6 0.9 0.6 -0.1
Reaction Time 0.6 1.2 2.1 1.4 1.4 -0.7 0.4
Verbal and Numeric Reasoning (VNR) 0.5 1.1 2.5 -1.0 -0.4 0.9 -1.6
Breast Cancer 0.6 1.4 3.5 -1.3 -1.9 0.4 0.2
Ovarian Cancer 4.6 6.0 7.8 -2.7 -2.2 2.8 -2.1
Prostate Cancer 0.1 0.2 0.6 0.3 0.1 -0.8 -0.0
Age at First Birth 3.3 4.8 7.4 2.4 2.7 -2.2 1.0
Bipolar Disorder (2011) 1.1 1.1 1.4 1.2 1.2 -1.0 0.8
Body Mass Index (BMI) (2010) 5.2 7.1 12.9 -2.7 -2.4 3.6 -1.6
Coronary Artery Disease (CAD) 0.5 0.6 1.4 0.5 0.1 -0.9 1.2
Crohns Disease (2012) 0.3 0.5 0.7 0.8 0.5 -0.9 0.5
Mean Putamen Volume 1.1 1.2 2.2 -1.5 -0.3 0.7 -1.4
Fasting Glucose 0.1 0.1 0.2 0.3 0.0 0.4 -0.3
HbA1C 5.9 6.6 14.4 -2.0 0.2 2.8 -3.8
HDL Cholesterol 0.1 0.2 0.5 -0.2 -0.7 -0.0 0.5
LDL Cholesterol 0.6 1.0 1.4 1.1 1.0 -0.6 1.2
Lupus 0.1 0.1 0.4 0.4 0.0 -0.1 0.6
Neuroticism (2016) 0.8 1.2 3.0 1.0 1.7 0.0 -0.8
Primary Biliary Cirrhosis 0.2 0.3 0.9 -0.6 -0.9 -0.0 -0.3
Rheumatoid Arthritis 0.0 0.1 0.2 0.0 -0.2 -0.2 0.4
Schizophrenia (2014) 1.5 3.4 7.7 -2.1 -2.8 1.1 -0.5
Triglycerides 0.3 0.5 1.0 0.3 0.6 0.7 1.0
Type 2 Diabetes (T2D) (2012) 0.4 0.5 1.1 0.3 1.0 -0.9 0.3
Ulcerative Colitis 1.6 2.4 3.9 -2.0 -1.5 0.9 -1.6
Blood Eosinophil Count 0.3 2.2 3.8 -1.8 -0.5 1.1 -2.0
Blood Platelet Count 0.2 2.8 4.0 2.0 1.7 -2.0 0.7
Blood Red Count 0.2 2.1 3.5 1.9 1.2 -1.1 1.5
Blood White Count 0.1 0.6 1.5 0.5 -0.1 -0.6 1.2
Heel T-Score 0.3 2.1 2.7 1.5 1.6 -1.2 1.6
BMI 0.4 2.6 7.3 -1.0 -2.7 -0.2 1.4
Height 0.1 2.0 4.9 1.3 2.2 -1.1 0.4
Waist Hip Ratio (WHR) 0.4 1.6 2.5 1.4 0.5 -1.3 1.6
Systolic Blood Pressure 0.1 0.4 1.1 0.7 1.1 -0.3 -0.1
Smoking Status 1.3 3.2 5.1 -1.8 -1.3 1.7 -2.2
Allergy or Eczema 0.2 0.6 1.1 -0.7 -0.9 1.1 -0.2
Cardiovascular Disease 0.0 0.1 0.2 0.4 0.2 0.2 0.1
Hypothyroidism (self reported) 1.1 2.5 5.8 -1.3 -0.6 1.5 -2.4
Respiratory disease 0.5 1.1 2.3 -0.9 -0.5 0.9 -1.5
Type 2 Diabetes (T2D) (2018) 0.3 0.6 1.0 1.0 0.6 -0.6 0.9
Lung FEV1/FVC ratio 0.5 2.3 5.9 -1.7 -2.4 0.7 0.2
Lung FVC 0.1 0.7 1.8 -0.2 1.4 0.5 -0.8
Neuroticism 1.0 2.3 6.4 1.6 2.5 -0.4 -0.6
Chronotype (morning person) 0.2 0.6 1.7 -0.3 -0.6 0.3 1.3
Hair Pigment 4.2 119.1 176.9 9.8 7.2 -12.3 13.3
Tanning 0.1 1.1 1.4 -1.0 -1.1 0.8 -1.2
Hand grip strength (left) 1.2 3.1 4.8 -1.8 -1.2 2.2 -1.7
Number of treatments/medications taken 1.0 1.7 4.5 1.4 2.1 -0.6 -0.0
Average weekly spirits intake 1.6 2.0 3.1 1.6 1.8 -1.3 0.7
Sensitivity / hurt feelings 1.0 1.8 4.7 1.5 2.2 0.2 -0.3
Frequency of depressed mood in last 2 weeks 0.6 0.9 2.0 1.2 1.4 -0.2 0.1
Hearing difficulty/problems: Yes 0.4 0.7 2.2 -0.6 0.2 0.3 -1.5
Relative age of first facial hair 1.6 3.2 5.4 -2.3 -2.3 0.9 -1.2
Other serious medical condition/disability diagnosed by doctor 2.4 3.1 4.4 2.1 1.9 -1.7 1.1
Ever used hormone-replacement therapy (HRT) 1.1 1.5 2.3 1.5 1.1 -0.4 1.4
Ever had hysterectomy (womb removed) 0.6 0.7 1.9 0.7 -0.1 -0.6 1.4
Systolic blood pressure, automated reading 0.0 0.1 0.4 -0.3 0.1 0.2 -0.6
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 1.1 0.8 1.1 -0.5 0.2
Angina 3.9 5.2 10.0 2.4 0.8 -2.0 3.2
Medication for hormone replacement therapy 0.2 0.2 0.4 0.6 0.7 -0.0 0.2
Vitamin and mineral supplements 0.1 0.1 0.2 -0.1 -0.5 0.4 0.1
Supplements: Zinc 0.2 0.3 0.5 0.7 -0.0 -0.3 0.7
Medication: Co-codamol 0.8 0.9 2.8 -0.4 0.3 1.7 -0.7
Medication: Metformin 0.7 0.9 1.4 1.2 0.9 -0.6 1.1
Diabetes (father) 0.1 0.1 0.1 -0.2 -0.4 0.2 -0.2
Diabetes (mother) 5.2 6.6 9.4 2.9 2.4 -1.7 3.1
Severe depression (siblings) 3.0 3.4 5.8 1.7 2.4 -2.2 0.5
Pack years adult smoking proportion 0.1 0.1 0.5 0.2 0.1 0.7 -0.1
Impedance of leg (right) 0.0 0.2 0.6 0.3 0.2 -0.8 0.1
Leg fat-free mass (left) 0.0 0.1 0.4 0.2 0.0 0.1 0.7
Trunk fat percentage 0.1 0.5 1.2 0.4 -0.6 -0.3 1.1
Hand grip strength (right) 0.7 1.8 2.8 -1.3 -0.5 1.7 -1.6
Townsend deprivation index at recruitment 0.1 0.1 0.3 -0.2 -0.6 0.2 0.1
Current tobacco smoking 0.4 0.7 1.3 -0.6 -1.2 0.6 0.8
Average weekly fortified wine intake 0.9 1.1 1.7 1.3 1.2 -0.6 0.9
Maternal smoking around birth 1.7 2.5 4.1 -2.0 -2.0 0.9 -1.0
Fed-up feelings 3.1 5.7 11.8 2.8 3.4 -1.7 0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 1.5 2.0 3.4 1.8 1.8 -1.2 0.5
Relative age voice broke 0.5 0.8 1.6 -1.3 -1.1 0.1 -0.5
Taking other prescription medications 0.3 0.5 0.9 0.9 1.0 -0.3 -0.2
Age when periods started (menarche) 0.7 1.6 4.2 -0.9 -0.3 2.0 -1.1
Bilateral oophorectomy (both ovaries removed) 1.4 1.6 2.1 1.3 1.5 -1.3 0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.1 0.5 -0.1 0.2 0.7 0.2
Tinnitus: Yes, but not now, but have in the past 1.0 1.1 2.4 0.3 1.4 -0.3 -1.5
Qualifications: CSEs or equivalent 0.2 0.3 0.6 0.2 0.7 -0.1 -0.8
Serious illness, injury or assault to yourself 0.8 0.9 1.4 1.1 0.7 -0.7 1.2
High blood pressure 0.4 1.2 2.7 1.1 1.6 -0.6 -0.6
Hayfever, allergic rhinitis or eczema 1.2 2.5 3.6 -1.7 -1.3 1.9 -1.4
Multivitamins +/- minerals 0.9 1.2 2.7 1.1 0.4 -0.9 1.6
Stomach or abdominal pain in last month 0.3 0.4 1.0 -0.1 0.2 1.0 -0.8
Supplements: Glucosamine 0.3 0.4 1.0 0.3 1.0 -0.5 -0.3
Diverticular disease/diverticulitis (self-reported) 1.8 2.1 3.1 -1.6 -1.0 1.8 -1.2
Medication: Atenolol 0.8 0.9 1.8 0.8 0.3 -1.3 1.1
Medication: Levothyroxine sodium 2.2 3.8 7.1 -1.5 -0.6 2.3 -2.7
Sitting height 0.1 0.9 2.5 -0.9 0.2 0.4 -1.6
Chronic bronchitis/emphysema (father) 1.0 1.2 3.1 -0.8 -0.0 1.0 -1.8
High blood pressure (mother) 0.9 1.2 2.7 -1.0 -1.6 0.7 0.8
Body mass index (BMI) 0.2 0.7 2.0 -0.2 -1.4 0.1 0.9
Impedance of leg (left) 0.0 0.1 0.4 0.1 0.1 -0.6 -0.2
Leg predicted mass (left) 0.0 0.1 0.5 0.2 -0.0 0.0 0.7
Trunk fat mass 0.1 0.4 1.1 0.3 -0.6 -0.2 1.1
Waist circumference 0.1 0.5 0.9 0.3 -0.9 0.3 1.0
Number of incorrect matches in round 0.3 0.6 1.5 1.2 0.7 0.3 0.5
Past tobacco smoking 1.7 3.1 6.8 1.4 0.6 -1.8 2.6
Alcohol usually taken with meals 0.1 0.2 0.6 -0.0 0.2 0.2 -0.8
Nervous feelings 0.9 1.7 4.2 1.5 2.1 0.1 -0.5
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.3 3.3 0.2 1.3 0.5 -1.8
Hearing difficulty/problems with background noise 0.6 1.0 2.1 -0.9 -0.8 1.5 -0.7
Hair/balding pattern: Pattern 2 1.5 1.9 4.4 1.6 0.5 -0.8 2.1
Had menopause 0.2 0.2 0.4 0.6 0.1 -0.3 0.7
Had other major operations 1.9 2.3 3.7 1.9 1.5 -0.9 1.6
Forced vital capacity (FVC) 0.1 0.5 1.0 -0.2 1.0 0.3 -0.8
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 1.7 0.3 -0.3 -0.4 1.3
Ever unenthusiastic/disinterested for a whole week 1.0 1.2 2.1 -1.1 -0.1 1.2 -1.5
Qualifications: None of the above 0.2 0.4 0.8 0.5 0.9 0.3 -0.6
Financial difficulties in last 2 years 0.0 0.0 0.0 0.1 -0.1 0.2 -0.1
Mouth/teeth dental problems 2.4 3.7 6.5 -2.5 -2.0 1.0 -1.8
Heart attack 0.7 0.9 1.6 1.3 0.8 -0.9 0.7
Allergy 2.4 5.4 9.0 2.1 1.3 -3.0 2.6
Pain all over the body in last month 0.4 0.5 1.3 -0.6 -1.2 0.3 0.2
Diabetes (self-reported) 1.2 1.9 4.1 1.4 0.7 -0.9 2.0
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 0.6 0.7 0.1 -0.3 0.8
Medication: Ramipril 0.3 0.4 0.6 0.7 -0.1 -0.6 0.8
Medication: Simvastatin 1.5 2.2 3.6 1.9 1.7 -1.1 0.9
Fluid intelligence score 0.1 0.1 0.4 0.2 0.0 -0.7 0.1
Illnesses of siblings 1.1 1.6 4.6 0.7 -0.8 -0.8 2.1
Neuroticism score 1.5 3.0 7.7 2.0 2.8 -0.5 -0.1
Weight 0.0 0.2 0.7 0.3 -0.4 -0.0 0.8
Impedance of arm (right) 0.1 0.3 0.5 0.7 0.7 -0.3 0.3
Arm fat percentage (right) 0.2 0.9 1.9 0.1 -1.4 -0.1 1.3
Trunk fat-free mass 0.0 0.0 0.1 0.2 0.3 0.1 0.2
Hip circumference 0.2 1.0 2.7 -0.7 -1.7 0.4 0.7
Time employed in main current job 1.6 1.9 3.0 -1.3 -0.2 1.7 -1.7
Alcohol intake versus 10 years previously 0.1 0.1 0.4 0.1 -0.0 0.1 -0.7
Father’s age at death 1.8 2.5 4.9 1.4 1.1 -2.2 1.4
Worrier / anxious feelings 1.1 2.2 4.7 -1.2 -0.2 1.6 -2.2
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.4 0.8 0.9 0.7 -0.4 0.3
Falls in the last year 0.6 0.8 1.3 -1.0 -0.8 1.1 -0.5
Hair/balding pattern: Pattern 3 0.5 0.8 1.9 0.9 1.4 -0.0 -0.6
Number of live births 1.2 1.7 2.6 1.6 1.6 -1.1 0.6
Forced expiratory volume in 1-second (FEV1) 0.1 0.3 0.6 -0.7 0.0 0.5 -0.5
Pulse rate 2.1 3.6 4.5 2.1 1.5 -1.8 2.1
Happiness 2.4 2.9 4.4 -1.7 -0.7 2.1 -1.9
Noisy workplace 0.7 0.8 1.6 -0.9 0.4 0.8 -1.3
Qualifications: A levels/AS levels or equivalent 0.1 0.1 0.4 -0.3 0.1 -0.1 -0.6
Serious illness, injury or assault of a close relative in last 2 years 1.4 1.6 2.4 -1.4 -0.9 1.2 -1.6
Mouth/teeth dental problems: Dentures 0.2 0.3 0.7 0.6 0.8 0.2 0.1
Asthma 0.8 1.5 3.3 -1.1 -0.7 1.1 -1.8
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 1.5 0.9 0.5 -1.2 1.0
Medication: Cholesterol lowering 0.1 0.1 0.2 0.5 -0.1 0.1 0.4
Depression (self-reported) 1.0 1.2 1.4 1.1 1.1 -1.2 0.9
Medication: Lansoprazole 0.7 0.8 1.4 1.2 0.8 -0.4 0.9
Prospective memory result 0.5 0.7 1.1 1.0 0.7 -0.8 0.5
Lung cancer (father) 0.3 0.4 0.8 0.9 0.8 -0.1 0.3
Illnesses of mother 0.6 0.7 2.3 -0.7 -0.0 0.1 -1.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.0 2.2 -1.5 -0.7 0.9 -0.8
Pulse wave Arterial Stiffness index 0.5 0.6 0.7 0.8 0.5 -0.9 0.8
Impedance of arm (left) 0.2 1.1 2.6 1.2 1.6 -0.7 0.2
Arm fat mass (right) 0.2 1.0 2.6 0.4 -1.0 -0.3 1.6
Trunk predicted mass 0.0 0.1 0.1 0.3 0.3 0.1 0.3
Standing height 0.1 1.1 3.6 0.8 1.9 -0.2 -0.3
Length of working week for main job 0.6 0.7 1.9 -0.5 -1.4 0.1 0.7
Exposure to tobacco smoke at home 1.3 1.4 1.9 -1.0 -1.0 1.4 -1.4
Breastfed as a baby 0.3 0.4 1.0 0.3 1.0 -0.6 -0.3
Tense / ‘highly strung’ 1.1 1.8 4.8 1.0 2.2 -0.2 -1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 2.1 3.2 8.0 1.7 2.8 0.7 -1.2
Hair/balding pattern: Pattern 4 1.4 3.4 4.9 -2.2 -1.9 1.4 -1.8
Birth weight of first child 1.1 2.1 2.3 -1.5 -1.4 1.4 -1.4
Peak expiratory flow (PEF) 0.2 0.4 0.9 -0.9 -0.8 -0.1 -0.2
Pulse wave reflection index 0.5 0.7 2.0 -0.3 0.7 0.3 -1.4
Ever highly irritable/argumentative for 2 days 0.3 0.4 0.9 0.2 0.7 -0.9 -0.3
Loud music exposure frequency 0.4 0.4 1.3 -0.6 0.1 0.1 -1.1
Qualifications: O levels/GCSEs or equivalent 0.1 0.1 0.2 -0.5 -0.2 -0.1 -0.5
Mouth/teeth dental problems: Bleeding gums 0.8 1.0 2.8 0.9 1.7 0.6 -0.2
Blood clot in the leg (DVT) 0.5 0.6 1.1 1.0 1.1 0.0 0.5
Medication: Paracetamol 0.1 0.1 0.5 -0.3 0.1 0.2 -0.7
Headache pain in last month 0.4 0.7 1.7 1.0 1.3 -0.4 0.1
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 0.7 -0.8 -0.3 0.2 -0.7
Glaucoma (self-reported) 0.5 0.6 1.4 0.7 1.2 -0.3 -0.7
Gout (self-reported) 0.7 1.0 1.9 0.8 1.1 -1.4 0.2
Hypothyroidism/myxoedema (self-reported) 0.6 1.2 2.3 -0.7 -0.2 1.4 -1.5
Medication: Amlodipine 1.7 2.4 3.6 1.7 1.9 -1.4 1.0
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.3 -0.0 -0.5 -0.0 0.1
Birth weight 1.4 3.1 4.7 -2.2 -1.8 1.2 -1.6
Chronic bronchitis/emphysema (mother) 0.3 0.3 0.5 0.4 0.7 -0.6 -0.5
High blood pressure (siblings) 1.5 2.2 3.6 -1.9 -0.9 1.3 -1.6
Forced vital capacity (FVC), Best measure 0.3 1.0 1.8 -1.2 0.1 0.9 -1.4
Body fat percentage 0.2 0.6 1.4 0.2 -1.0 -0.3 1.2
Leg fat percentage (right) 0.2 0.9 1.8 -0.0 -1.4 -0.5 1.2
Arm fat-free mass (right) 0.0 0.2 0.6 0.4 0.2 -0.2 0.8
Exposure to tobacco smoke outside home 0.4 0.5 1.2 0.9 1.1 0.3 -0.4
Comparative body size at age 10 0.1 0.3 0.6 -0.1 -0.8 -0.2 0.8
Number of full brothers 2.4 3.1 7.8 -0.8 0.9 1.7 -2.8
Worry too long after embarrassment 0.4 0.7 1.7 -0.8 -0.1 0.8 -1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.7 2.0 0.6 1.4 0.4 -0.7
Wheeze or whistling in the chest in last year 0.3 0.6 1.4 0.3 1.0 0.1 -1.2
Number of children fathered 6.1 6.8 12.6 -2.1 -1.1 3.5 -3.0
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.3 0.6 -0.5 0.2 0.5 -0.8
Age at first live birth 0.4 0.7 1.4 0.6 0.5 -1.2 0.8
Pulse wave peak to peak time 0.5 0.6 0.8 -0.8 -0.4 0.7 -0.9
Health satisfaction 0.7 0.9 1.7 -0.9 -1.0 1.3 -0.5
Shortness of breath walking on level ground 0.7 0.9 2.0 -0.7 -0.7 1.4 -0.7
Qualifications: College or University degree 0.1 0.4 0.9 -0.9 -0.7 -0.3 -0.4
Eye problems/disorders: None of the above 2.6 3.0 5.2 -2.2 -2.3 1.2 -0.8
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.2 1.1 0.9 -0.0 0.5
Emphysema/chronic bronchitis 0.1 0.1 0.2 -0.2 -0.4 -0.0 -0.1
Medication for pain relief, constipation, heartburn 1.2 2.1 3.8 -1.2 -1.0 1.9 -1.4
Neck or shoulder pain in last month 0.0 0.0 0.1 -0.0 -0.2 0.0 -0.3
Medication: Blood pressure 0.2 0.3 0.3 0.6 0.6 -0.5 0.5
Angina (self-reported) 4.4 5.8 9.7 2.6 1.1 -2.3 3.1
Migraine (self-reported) 0.8 1.0 2.7 -0.7 0.3 0.8 -1.6
Medication: Ibuprofen 0.9 1.0 1.4 1.1 0.8 -1.2 0.9
Medication: Allopurinol 0.4 0.6 1.5 0.5 1.2 -0.7 -0.3
Medication: Omeprazole 0.6 0.7 1.6 0.6 -0.0 -0.8 1.3
Medication: Seretide 50 evohaler 0.0 0.0 0.1 0.2 0.1 0.2 0.1
Mean time to correctly identify matches 0.7 1.4 2.8 1.7 1.2 -0.6 1.0
Heart disease (mother) 0.2 0.3 0.8 -0.4 -0.9 0.2 -0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.4 1.6 4.9 1.0 0.1 -2.2 0.8
Whole body fat mass 0.1 0.5 1.3 0.3 -0.8 -0.2 1.2
Leg fat mass (right) 0.2 0.8 1.8 0.2 -1.0 -0.4 1.4
Arm predicted mass (right) 0.0 0.2 0.5 0.3 0.2 -0.1 0.7
Pulse rate, automated reading 2.2 7.2 9.0 3.0 2.7 -2.9 2.1
Alcohol intake frequency. 0.7 1.7 2.5 1.5 1.6 -1.2 0.9
Comparative height size at age 10 0.2 1.2 3.5 1.1 1.9 -0.3 0.3
Number of full sisters 0.5 0.6 1.6 0.8 0.5 -1.2 0.4
Suffer from ‘nerves’ 0.9 1.4 3.8 1.4 1.9 -0.3 -0.1
Overall health rating 1.1 2.4 5.9 1.9 2.4 -0.6 -0.3
Chest pain or discomfort 0.1 0.1 0.2 0.4 -0.3 -0.1 0.5
Had major operations 1.1 1.3 1.6 1.2 0.9 -1.2 1.3
Age at last live birth 1.4 2.0 3.0 1.4 1.6 -1.7 0.6
Family relationship satisfaction 1.1 1.4 2.4 -1.0 -0.4 1.6 -1.4
Leg pain on walking 1.5 1.8 4.2 -0.8 -0.1 1.6 -2.1
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.4 0.3 0.0 -0.6 0.6
Commuting to job workplace: Car/motor vehicle 0.8 0.9 2.6 0.4 -0.5 -0.9 1.6
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 1.2 0.7 0.4 -1.1 0.8
Medication: Aspirin 1.6 2.2 4.8 1.2 0.4 -1.5 2.2
Supplements: Vitamin C 2.1 2.5 7.6 -1.3 0.0 0.8 -2.8
Knee pain experienced in last month 0.9 1.4 2.9 0.3 1.2 1.2 -1.7
Hypertension (Self-reported) 0.5 1.3 2.8 1.3 1.7 -0.9 -0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.0 1.2 3.4 0.3 -0.7 -0.9 1.8
Illnesses of father: Heart disease 2.9 4.0 10.4 -1.9 -3.2 1.3 0.4
Illnesses of siblings: Diabetes 0.9 1.1 2.4 0.4 1.6 -0.3 -1.3
Smoking status: Previous 1.0 1.5 4.5 -0.9 -0.1 0.9 -2.1
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.5 -0.4 -0.3 0.4 -0.7
Whole body fat-free mass 0.0 0.1 0.2 0.2 0.2 0.1 0.4
Leg fat-free mass (right) 0.0 0.1 0.1 -0.0 -0.0 0.3 0.4
Arm fat percentage (left) 0.2 0.8 1.8 0.3 -1.0 -0.3 1.4
Average weekly red wine intake 0.4 0.6 1.3 -0.7 -1.2 0.4 -0.4
Handedness (chirality/laterality): Left-handed 1.5 1.8 5.2 -0.8 -0.5 2.3 -1.0
Mood swings 1.5 2.8 7.8 1.6 2.8 -0.7 -0.5
Loneliness, isolation 1.9 2.6 5.0 2.1 2.2 -1.0 0.2
Long-standing illness, disability or infirmity 1.9 2.9 5.5 2.3 2.1 -0.9 1.0
Ever had bowel cancer screening 1.0 1.2 1.6 1.3 1.2 -0.8 0.9
Diabetes diagnosed by doctor 0.9 1.5 2.7 1.6 1.1 -0.7 1.3
Ever had stillbirth, spontaneous miscarriage or termination 1.3 1.4 3.2 -0.9 0.1 1.3 -1.8
Friendships satisfaction 1.5 1.9 2.7 -1.4 -1.1 1.6 -1.3
Qualifications: nursing, teaching 0.5 0.8 1.0 -1.0 -0.9 0.7 -0.9
Commuting to job workplace: Walk 1.1 1.1 3.4 0.7 1.8 -0.2 -0.8
Eye problems/disorders: Cataract 0.8 1.0 1.9 1.4 1.2 -0.3 0.7
Mouth/teeth dental problems: Mouth ulcers 2.8 4.5 6.3 2.4 1.5 -1.9 2.5
Medication for cholesterol 1.7 2.6 6.4 -1.8 -2.5 1.1 0.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.8 3.3 4.9 2.1 2.2 -1.9 0.6
Back pain experienced in last month 0.8 1.1 3.2 0.8 1.8 -0.6 -0.5
Mineral and other dietary supplements 0.8 1.1 2.7 -0.5 -1.6 0.7 1.0
Breast cancer (self-reported) 1.0 1.2 1.8 1.3 1.3 -1.0 0.4
Asthma (self-reported) 1.2 2.4 4.9 -1.5 -0.9 1.3 -2.2
Osteoporosis (self-reported) 0.1 0.1 0.4 -0.3 -0.0 -0.7 -0.2
Osteoarthritis (self-reported) 0.1 0.1 0.2 0.4 0.1 -0.3 0.2
Medication: Aspirin 1.9 2.5 4.4 1.5 0.8 -1.6 2.1
Medication: Gliclazide 0.5 0.5 1.0 0.7 0.7 -1.0 0.1
Illnesses of father: None of the above (group 1) 2.3 2.9 5.8 1.8 2.4 -1.5 0.3
Smoking status: Current 0.5 0.9 1.5 -0.9 -1.2 1.0 0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 1.0 -1.0 -0.2 0.7 -1.0
Whole body water mass 0.0 0.1 0.2 0.2 0.2 0.1 0.4
Leg predicted mass (right) 0.0 0.1 0.1 -0.1 -0.1 0.4 0.3
Arm fat mass (left) 0.2 0.7 1.8 0.4 -0.8 -0.2 1.3
Number of self-reported non-cancer illnesses 0.8 1.4 2.4 1.1 1.5 -0.8 -1.2
Average weekly champagne plus white wine intake 0.2 0.2 0.6 0.1 0.5 -0.8 0.2
Miserableness 3.4 5.9 10.1 3.2 3.0 -1.7 1.4
Guilty feelings 0.4 0.6 1.2 1.0 1.1 0.1 0.3
Wears glasses or contact lenses 0.2 0.3 0.6 -0.4 -0.8 -0.6 -0.3
Ever taken oral contraceptive pill 1.5 1.6 3.3 -1.2 -1.3 1.8 -0.4
Hearing aid user 0.5 0.5 0.9 0.1 -0.8 -0.8 0.9
Mother’s age at death 0.3 0.3 0.6 0.4 0.1 -0.8 0.7
Financial situation satisfaction 0.3 0.4 0.7 -0.4 0.1 0.8 -0.8
Tinnitus: Yes, now most or all of the time 0.4 0.4 0.9 -0.2 -0.9 -0.5 0.7
Commuting to job workplace: Public transport 0.1 0.2 0.3 0.2 -0.6 0.1 0.5
Eye problems/disorders: Glaucoma 0.9 1.1 2.5 1.0 1.6 -0.0 -0.8
Medication: Blood pressure 2.1 3.9 7.7 2.2 2.8 -1.7 0.3
Pain type(s) experienced in last month: Hip pain 0.4 0.5 0.7 -0.8 -0.8 0.6 -0.6
Supplements: Fish oil (including cod liver oil) 0.6 0.8 2.5 -0.3 0.8 -0.1 -1.6
High cholesterol (Self-reported) 1.3 2.3 4.1 1.5 0.7 -1.5 2.0
Medication: Bendroflumethiazide 1.0 1.6 2.2 1.5 1.2 -1.2 1.1
Medication: Paracetamol 0.1 0.1 0.3 -0.0 0.4 -0.6 -0.3
Medication: Lisinopril 0.5 0.7 1.0 0.9 1.0 -1.0 0.1
Medication: Atorvastatin 2.5 3.2 6.2 1.8 0.6 -1.6 2.5
Illnesses of father: High blood pressure 1.0 1.2 2.4 -1.5 -1.2 0.6 -0.9
Alcohol drinker status: Never 0.6 0.7 1.6 0.7 0.3 -0.8 1.3
Ever smoked 1.1 2.0 3.2 -1.2 -0.8 1.6 -1.8
Basal metabolic rate 0.0 0.1 0.3 0.2 -0.0 0.0 0.6
Leg fat percentage (left) 0.2 0.8 2.0 -0.2 -1.4 -0.4 1.0
Arm fat-free mass (left) 0.0 0.1 0.5 0.3 0.0 -0.1 0.7
Number of operations (self-reported) 1.4 2.1 4.0 1.8 2.0 -0.7 0.7
Average weekly beer plus cider intake 0.9 1.4 3.5 -0.5 0.4 1.9 -1.2
Irritability 0.2 0.4 1.4 0.2 0.3 -1.2 -0.1
Risk taking 0.7 1.1 2.2 -1.2 -0.5 0.7 -1.5
Ever had prostate specific antigen (PSA) test 0.4 0.4 0.8 0.7 0.9 0.6 0.1
Fractured/broken bones in last 5 years 0.0 0.1 0.1 -0.3 -0.3 0.2 -0.1
Age started oral contraceptive pill 0.6 0.8 1.9 0.8 0.6 -0.5 1.4
Diastolic blood pressure, automated reading 0.1 0.4 0.8 0.6 0.9 -0.6 -0.1
Ever depressed for a whole week 0.7 0.9 2.0 1.3 1.4 -0.3 -0.0
Unable to work because of sickness or disability 0.9 1.1 2.2 1.4 1.5 -0.7 0.2
Commuting to job workplace: Cycle 0.1 0.2 0.4 -0.1 0.6 0.1 -0.5
Myopia 0.1 0.1 0.3 -0.2 -0.4 0.5 0.3
Vascular/heart problems diagnosed by doctor 0.7 1.9 3.3 -1.8 -1.8 1.1 -0.3
Cholesterol lowering medication 3.8 5.6 8.2 2.7 2.9 -2.2 1.5
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 2.6 0.5 -0.4 -0.8 1.6
Pain experienced in last month 0.4 0.7 1.2 -0.3 -1.0 -0.7 1.1
Supplements: Calcium 0.3 0.4 0.5 -0.7 -0.5 -0.7 -0.5
Basal cell carcinoma (self-reported) 1.8 2.2 3.6 1.5 1.9 -1.4 1.0
Heart attack/myocardial infarction (self-reported) 0.8 1.1 1.9 1.4 0.9 -1.0 0.7
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 0.9 0.9 1.0 0.2 0.3
Heart disease (siblings) 0.6 0.8 2.5 0.6 1.6 -0.3 -0.5
Alcohol drinker status: Previous 0.6 0.7 1.2 0.5 1.1 -1.1 -0.1
Pack years of smoking 0.2 0.3 1.0 -0.0 0.0 1.0 -0.3
Impedance of whole body 0.0 0.2 0.5 0.5 0.7 -0.4 -0.1
Leg fat mass (left) 0.2 0.6 1.4 0.1 -1.0 -0.3 1.2
Arm predicted mass (left) 0.0 0.2 0.6 0.1 -0.2 0.1 0.8