Hub : Genes

LOC100129550

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0850	0.0230	2.2e-07	0.101	0.052	0.075	0.065	0.091	2.8e-12	6.2e-07	1.9e-09	2.1e-08	3.8e-11
2	TCGA	Brain Lower Grade Glioma	0.0275	0.0143	1.6e-03	0.022	0.031	0.025	NA	0.023	1.4e-03	1.7e-04	7.2e-04	NA	1.1e-03
3	TCGA	Prostate Adenocarcinoma	0.0394	0.0236	5.4e-03	0.013	0.006	0.002	NA	0.001	1.4e-02	6.5e-02	1.6e-01	NA	2.7e-01
4	TCGA	Thyroid Carcinoma	0.0810	0.0360	2.1e-03	0.029	0.022	0.010	NA	0.014	6.9e-04	3.0e-03	3.2e-02	NA	1.3e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.4	0.6	1.2	0.3	-0.3	-1.0	1.1
Bipolar Disorder or Schizophrenia	0.7	1.8	4.3	-1.4	-2.1	0.9	0.1
Depressed Affect (Nagel 2018)	3.9	8.1	17.7	3.4	4.2	-1.7	0.4
Depression (Nagel 2018)	0.8	1.2	2.6	1.2	1.6	-0.5	-0.5
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.8	-0.9	-0.4	0.2	-0.8
Neuroticism (Nagel 2018)	1.3	3.0	7.6	1.6	2.8	-0.3	-1.3
Schizophrenia (2018)	1.7	3.6	6.0	-2.0	-2.4	1.9	-0.8
Schizophrenia vs Biploar Disorder	1.4	1.9	3.1	-1.8	-1.4	1.3	-0.9
Worry (Nagel 2018)	0.7	1.5	3.2	0.7	1.8	0.3	-1.5
Alzheimer’s Disease (in mother)	2.0	2.3	5.7	-1.1	-0.1	1.5	-2.4
Alzheimer’s Disease (in father)	0.4	0.4	0.8	0.6	0.7	-0.9	0.1
Alzheimer’s Disease (including proxy)	0.8	1.1	3.5	-0.0	0.8	0.6	-1.9
Crohns Disease (2017)	0.8	1.7	3.1	1.4	0.9	-0.9	1.8
Irritable Bowel Disease (IBD)	0.1	0.2	0.3	-0.3	-0.6	-0.1	0.6
Ulcerative Colitis (UC)	1.0	1.9	3.3	-1.8	-1.8	0.5	-0.9
Major Depression (MDD)	0.3	0.4	0.9	0.6	0.9	0.6	-0.1
Reaction Time	0.6	1.2	2.1	1.4	1.4	-0.7	0.4
Verbal and Numeric Reasoning (VNR)	0.5	1.1	2.5	-1.0	-0.4	0.9	-1.6
Breast Cancer	0.6	1.4	3.5	-1.3	-1.9	0.4	0.2
Ovarian Cancer	4.6	6.0	7.8	-2.7	-2.2	2.8	-2.1
Prostate Cancer	0.1	0.2	0.6	0.3	0.1	-0.8	-0.0
Age at First Birth	3.3	4.8	7.4	2.4	2.7	-2.2	1.0
Bipolar Disorder (2011)	1.1	1.1	1.4	1.2	1.2	-1.0	0.8
Body Mass Index (BMI) (2010)	5.2	7.1	12.9	-2.7	-2.4	3.6	-1.6
Coronary Artery Disease (CAD)	0.5	0.6	1.4	0.5	0.1	-0.9	1.2
Crohns Disease (2012)	0.3	0.5	0.7	0.8	0.5	-0.9	0.5
Mean Putamen Volume	1.1	1.2	2.2	-1.5	-0.3	0.7	-1.4
Fasting Glucose	0.1	0.1	0.2	0.3	0.0	0.4	-0.3
HbA1C	5.9	6.6	14.4	-2.0	0.2	2.8	-3.8
HDL Cholesterol	0.1	0.2	0.5	-0.2	-0.7	-0.0	0.5
LDL Cholesterol	0.6	1.0	1.4	1.1	1.0	-0.6	1.2
Lupus	0.1	0.1	0.4	0.4	0.0	-0.1	0.6
Neuroticism (2016)	0.8	1.2	3.0	1.0	1.7	0.0	-0.8
Primary Biliary Cirrhosis	0.2	0.3	0.9	-0.6	-0.9	-0.0	-0.3
Rheumatoid Arthritis	0.0	0.1	0.2	0.0	-0.2	-0.2	0.4
Schizophrenia (2014)	1.5	3.4	7.7	-2.1	-2.8	1.1	-0.5
Triglycerides	0.3	0.5	1.0	0.3	0.6	0.7	1.0
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.1	0.3	1.0	-0.9	0.3
Ulcerative Colitis	1.6	2.4	3.9	-2.0	-1.5	0.9	-1.6
Blood Eosinophil Count	0.3	2.2	3.8	-1.8	-0.5	1.1	-2.0
Blood Platelet Count	0.2	2.8	4.0	2.0	1.7	-2.0	0.7
Blood Red Count	0.2	2.1	3.5	1.9	1.2	-1.1	1.5
Blood White Count	0.1	0.6	1.5	0.5	-0.1	-0.6	1.2
Heel T-Score	0.3	2.1	2.7	1.5	1.6	-1.2	1.6
BMI	0.4	2.6	7.3	-1.0	-2.7	-0.2	1.4
Height	0.1	2.0	4.9	1.3	2.2	-1.1	0.4
Waist Hip Ratio (WHR)	0.4	1.6	2.5	1.4	0.5	-1.3	1.6
Systolic Blood Pressure	0.1	0.4	1.1	0.7	1.1	-0.3	-0.1
Smoking Status	1.3	3.2	5.1	-1.8	-1.3	1.7	-2.2
Allergy or Eczema	0.2	0.6	1.1	-0.7	-0.9	1.1	-0.2
Cardiovascular Disease	0.0	0.1	0.2	0.4	0.2	0.2	0.1
Hypothyroidism (self reported)	1.1	2.5	5.8	-1.3	-0.6	1.5	-2.4
Respiratory disease	0.5	1.1	2.3	-0.9	-0.5	0.9	-1.5
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.0	1.0	0.6	-0.6	0.9
Lung FEV1/FVC ratio	0.5	2.3	5.9	-1.7	-2.4	0.7	0.2
Lung FVC	0.1	0.7	1.8	-0.2	1.4	0.5	-0.8
Neuroticism	1.0	2.3	6.4	1.6	2.5	-0.4	-0.6
Chronotype (morning person)	0.2	0.6	1.7	-0.3	-0.6	0.3	1.3
Hair Pigment	4.2	119.1	176.9	9.8	7.2	-12.3	13.3
Tanning	0.1	1.1	1.4	-1.0	-1.1	0.8	-1.2
Hand grip strength (left)	1.2	3.1	4.8	-1.8	-1.2	2.2	-1.7
Number of treatments/medications taken	1.0	1.7	4.5	1.4	2.1	-0.6	-0.0
Average weekly spirits intake	1.6	2.0	3.1	1.6	1.8	-1.3	0.7
Sensitivity / hurt feelings	1.0	1.8	4.7	1.5	2.2	0.2	-0.3
Frequency of depressed mood in last 2 weeks	0.6	0.9	2.0	1.2	1.4	-0.2	0.1
Hearing difficulty/problems: Yes	0.4	0.7	2.2	-0.6	0.2	0.3	-1.5
Relative age of first facial hair	1.6	3.2	5.4	-2.3	-2.3	0.9	-1.2
Other serious medical condition/disability diagnosed by doctor	2.4	3.1	4.4	2.1	1.9	-1.7	1.1
Ever used hormone-replacement therapy (HRT)	1.1	1.5	2.3	1.5	1.1	-0.4	1.4
Ever had hysterectomy (womb removed)	0.6	0.7	1.9	0.7	-0.1	-0.6	1.4
Systolic blood pressure, automated reading	0.0	0.1	0.4	-0.3	0.1	0.2	-0.6
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.1	0.8	1.1	-0.5	0.2
Angina	3.9	5.2	10.0	2.4	0.8	-2.0	3.2
Medication for hormone replacement therapy	0.2	0.2	0.4	0.6	0.7	-0.0	0.2
Vitamin and mineral supplements	0.1	0.1	0.2	-0.1	-0.5	0.4	0.1
Supplements: Zinc	0.2	0.3	0.5	0.7	-0.0	-0.3	0.7
Medication: Co-codamol	0.8	0.9	2.8	-0.4	0.3	1.7	-0.7
Medication: Metformin	0.7	0.9	1.4	1.2	0.9	-0.6	1.1
Diabetes (father)	0.1	0.1	0.1	-0.2	-0.4	0.2	-0.2
Diabetes (mother)	5.2	6.6	9.4	2.9	2.4	-1.7	3.1
Severe depression (siblings)	3.0	3.4	5.8	1.7	2.4	-2.2	0.5
Pack years adult smoking proportion	0.1	0.1	0.5	0.2	0.1	0.7	-0.1
Impedance of leg (right)	0.0	0.2	0.6	0.3	0.2	-0.8	0.1
Leg fat-free mass (left)	0.0	0.1	0.4	0.2	0.0	0.1	0.7
Trunk fat percentage	0.1	0.5	1.2	0.4	-0.6	-0.3	1.1
Hand grip strength (right)	0.7	1.8	2.8	-1.3	-0.5	1.7	-1.6
Townsend deprivation index at recruitment	0.1	0.1	0.3	-0.2	-0.6	0.2	0.1
Current tobacco smoking	0.4	0.7	1.3	-0.6	-1.2	0.6	0.8
Average weekly fortified wine intake	0.9	1.1	1.7	1.3	1.2	-0.6	0.9
Maternal smoking around birth	1.7	2.5	4.1	-2.0	-2.0	0.9	-1.0
Fed-up feelings	3.1	5.7	11.8	2.8	3.4	-1.7	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	3.4	1.8	1.8	-1.2	0.5
Relative age voice broke	0.5	0.8	1.6	-1.3	-1.1	0.1	-0.5
Taking other prescription medications	0.3	0.5	0.9	0.9	1.0	-0.3	-0.2
Age when periods started (menarche)	0.7	1.6	4.2	-0.9	-0.3	2.0	-1.1
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	2.1	1.3	1.5	-1.3	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.1	0.5	-0.1	0.2	0.7	0.2
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	2.4	0.3	1.4	-0.3	-1.5
Qualifications: CSEs or equivalent	0.2	0.3	0.6	0.2	0.7	-0.1	-0.8
Serious illness, injury or assault to yourself	0.8	0.9	1.4	1.1	0.7	-0.7	1.2
High blood pressure	0.4	1.2	2.7	1.1	1.6	-0.6	-0.6
Hayfever, allergic rhinitis or eczema	1.2	2.5	3.6	-1.7	-1.3	1.9	-1.4
Multivitamins +/- minerals	0.9	1.2	2.7	1.1	0.4	-0.9	1.6
Stomach or abdominal pain in last month	0.3	0.4	1.0	-0.1	0.2	1.0	-0.8
Supplements: Glucosamine	0.3	0.4	1.0	0.3	1.0	-0.5	-0.3
Diverticular disease/diverticulitis (self-reported)	1.8	2.1	3.1	-1.6	-1.0	1.8	-1.2
Medication: Atenolol	0.8	0.9	1.8	0.8	0.3	-1.3	1.1
Medication: Levothyroxine sodium	2.2	3.8	7.1	-1.5	-0.6	2.3	-2.7
Sitting height	0.1	0.9	2.5	-0.9	0.2	0.4	-1.6
Chronic bronchitis/emphysema (father)	1.0	1.2	3.1	-0.8	-0.0	1.0	-1.8
High blood pressure (mother)	0.9	1.2	2.7	-1.0	-1.6	0.7	0.8
Body mass index (BMI)	0.2	0.7	2.0	-0.2	-1.4	0.1	0.9
Impedance of leg (left)	0.0	0.1	0.4	0.1	0.1	-0.6	-0.2
Leg predicted mass (left)	0.0	0.1	0.5	0.2	-0.0	0.0	0.7
Trunk fat mass	0.1	0.4	1.1	0.3	-0.6	-0.2	1.1
Waist circumference	0.1	0.5	0.9	0.3	-0.9	0.3	1.0
Number of incorrect matches in round	0.3	0.6	1.5	1.2	0.7	0.3	0.5
Past tobacco smoking	1.7	3.1	6.8	1.4	0.6	-1.8	2.6
Alcohol usually taken with meals	0.1	0.2	0.6	-0.0	0.2	0.2	-0.8
Nervous feelings	0.9	1.7	4.2	1.5	2.1	0.1	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	3.3	0.2	1.3	0.5	-1.8
Hearing difficulty/problems with background noise	0.6	1.0	2.1	-0.9	-0.8	1.5	-0.7
Hair/balding pattern: Pattern 2	1.5	1.9	4.4	1.6	0.5	-0.8	2.1
Had menopause	0.2	0.2	0.4	0.6	0.1	-0.3	0.7
Had other major operations	1.9	2.3	3.7	1.9	1.5	-0.9	1.6
Forced vital capacity (FVC)	0.1	0.5	1.0	-0.2	1.0	0.3	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.7	0.3	-0.3	-0.4	1.3
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	2.1	-1.1	-0.1	1.2	-1.5
Qualifications: None of the above	0.2	0.4	0.8	0.5	0.9	0.3	-0.6
Financial difficulties in last 2 years	0.0	0.0	0.0	0.1	-0.1	0.2	-0.1
Mouth/teeth dental problems	2.4	3.7	6.5	-2.5	-2.0	1.0	-1.8
Heart attack	0.7	0.9	1.6	1.3	0.8	-0.9	0.7
Allergy	2.4	5.4	9.0	2.1	1.3	-3.0	2.6
Pain all over the body in last month	0.4	0.5	1.3	-0.6	-1.2	0.3	0.2
Diabetes (self-reported)	1.2	1.9	4.1	1.4	0.7	-0.9	2.0
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.6	0.7	0.1	-0.3	0.8
Medication: Ramipril	0.3	0.4	0.6	0.7	-0.1	-0.6	0.8
Medication: Simvastatin	1.5	2.2	3.6	1.9	1.7	-1.1	0.9
Fluid intelligence score	0.1	0.1	0.4	0.2	0.0	-0.7	0.1
Illnesses of siblings	1.1	1.6	4.6	0.7	-0.8	-0.8	2.1
Neuroticism score	1.5	3.0	7.7	2.0	2.8	-0.5	-0.1
Weight	0.0	0.2	0.7	0.3	-0.4	-0.0	0.8
Impedance of arm (right)	0.1	0.3	0.5	0.7	0.7	-0.3	0.3
Arm fat percentage (right)	0.2	0.9	1.9	0.1	-1.4	-0.1	1.3
Trunk fat-free mass	0.0	0.0	0.1	0.2	0.3	0.1	0.2
Hip circumference	0.2	1.0	2.7	-0.7	-1.7	0.4	0.7
Time employed in main current job	1.6	1.9	3.0	-1.3	-0.2	1.7	-1.7
Alcohol intake versus 10 years previously	0.1	0.1	0.4	0.1	-0.0	0.1	-0.7
Father’s age at death	1.8	2.5	4.9	1.4	1.1	-2.2	1.4
Worrier / anxious feelings	1.1	2.2	4.7	-1.2	-0.2	1.6	-2.2
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	0.8	0.9	0.7	-0.4	0.3
Falls in the last year	0.6	0.8	1.3	-1.0	-0.8	1.1	-0.5
Hair/balding pattern: Pattern 3	0.5	0.8	1.9	0.9	1.4	-0.0	-0.6
Number of live births	1.2	1.7	2.6	1.6	1.6	-1.1	0.6
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.6	-0.7	0.0	0.5	-0.5
Pulse rate	2.1	3.6	4.5	2.1	1.5	-1.8	2.1
Happiness	2.4	2.9	4.4	-1.7	-0.7	2.1	-1.9
Noisy workplace	0.7	0.8	1.6	-0.9	0.4	0.8	-1.3
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.4	-0.3	0.1	-0.1	-0.6
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	2.4	-1.4	-0.9	1.2	-1.6
Mouth/teeth dental problems: Dentures	0.2	0.3	0.7	0.6	0.8	0.2	0.1
Asthma	0.8	1.5	3.3	-1.1	-0.7	1.1	-1.8
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.5	0.9	0.5	-1.2	1.0
Medication: Cholesterol lowering	0.1	0.1	0.2	0.5	-0.1	0.1	0.4
Depression (self-reported)	1.0	1.2	1.4	1.1	1.1	-1.2	0.9
Medication: Lansoprazole	0.7	0.8	1.4	1.2	0.8	-0.4	0.9
Prospective memory result	0.5	0.7	1.1	1.0	0.7	-0.8	0.5
Lung cancer (father)	0.3	0.4	0.8	0.9	0.8	-0.1	0.3
Illnesses of mother	0.6	0.7	2.3	-0.7	-0.0	0.1	-1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.2	-1.5	-0.7	0.9	-0.8
Pulse wave Arterial Stiffness index	0.5	0.6	0.7	0.8	0.5	-0.9	0.8
Impedance of arm (left)	0.2	1.1	2.6	1.2	1.6	-0.7	0.2
Arm fat mass (right)	0.2	1.0	2.6	0.4	-1.0	-0.3	1.6
Trunk predicted mass	0.0	0.1	0.1	0.3	0.3	0.1	0.3
Standing height	0.1	1.1	3.6	0.8	1.9	-0.2	-0.3
Length of working week for main job	0.6	0.7	1.9	-0.5	-1.4	0.1	0.7
Exposure to tobacco smoke at home	1.3	1.4	1.9	-1.0	-1.0	1.4	-1.4
Breastfed as a baby	0.3	0.4	1.0	0.3	1.0	-0.6	-0.3
Tense / ‘highly strung’	1.1	1.8	4.8	1.0	2.2	-0.2	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	2.1	3.2	8.0	1.7	2.8	0.7	-1.2
Hair/balding pattern: Pattern 4	1.4	3.4	4.9	-2.2	-1.9	1.4	-1.8
Birth weight of first child	1.1	2.1	2.3	-1.5	-1.4	1.4	-1.4
Peak expiratory flow (PEF)	0.2	0.4	0.9	-0.9	-0.8	-0.1	-0.2
Pulse wave reflection index	0.5	0.7	2.0	-0.3	0.7	0.3	-1.4
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.9	0.2	0.7	-0.9	-0.3
Loud music exposure frequency	0.4	0.4	1.3	-0.6	0.1	0.1	-1.1
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.2	-0.5	-0.2	-0.1	-0.5
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	2.8	0.9	1.7	0.6	-0.2
Blood clot in the leg (DVT)	0.5	0.6	1.1	1.0	1.1	0.0	0.5
Medication: Paracetamol	0.1	0.1	0.5	-0.3	0.1	0.2	-0.7
Headache pain in last month	0.4	0.7	1.7	1.0	1.3	-0.4	0.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.7	-0.8	-0.3	0.2	-0.7
Glaucoma (self-reported)	0.5	0.6	1.4	0.7	1.2	-0.3	-0.7
Gout (self-reported)	0.7	1.0	1.9	0.8	1.1	-1.4	0.2
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	2.3	-0.7	-0.2	1.4	-1.5
Medication: Amlodipine	1.7	2.4	3.6	1.7	1.9	-1.4	1.0
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.3	-0.0	-0.5	-0.0	0.1
Birth weight	1.4	3.1	4.7	-2.2	-1.8	1.2	-1.6
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.5	0.4	0.7	-0.6	-0.5
High blood pressure (siblings)	1.5	2.2	3.6	-1.9	-0.9	1.3	-1.6
Forced vital capacity (FVC), Best measure	0.3	1.0	1.8	-1.2	0.1	0.9	-1.4
Body fat percentage	0.2	0.6	1.4	0.2	-1.0	-0.3	1.2
Leg fat percentage (right)	0.2	0.9	1.8	-0.0	-1.4	-0.5	1.2
Arm fat-free mass (right)	0.0	0.2	0.6	0.4	0.2	-0.2	0.8
Exposure to tobacco smoke outside home	0.4	0.5	1.2	0.9	1.1	0.3	-0.4
Comparative body size at age 10	0.1	0.3	0.6	-0.1	-0.8	-0.2	0.8
Number of full brothers	2.4	3.1	7.8	-0.8	0.9	1.7	-2.8
Worry too long after embarrassment	0.4	0.7	1.7	-0.8	-0.1	0.8	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	2.0	0.6	1.4	0.4	-0.7
Wheeze or whistling in the chest in last year	0.3	0.6	1.4	0.3	1.0	0.1	-1.2
Number of children fathered	6.1	6.8	12.6	-2.1	-1.1	3.5	-3.0
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.6	-0.5	0.2	0.5	-0.8
Age at first live birth	0.4	0.7	1.4	0.6	0.5	-1.2	0.8
Pulse wave peak to peak time	0.5	0.6	0.8	-0.8	-0.4	0.7	-0.9
Health satisfaction	0.7	0.9	1.7	-0.9	-1.0	1.3	-0.5
Shortness of breath walking on level ground	0.7	0.9	2.0	-0.7	-0.7	1.4	-0.7
Qualifications: College or University degree	0.1	0.4	0.9	-0.9	-0.7	-0.3	-0.4
Eye problems/disorders: None of the above	2.6	3.0	5.2	-2.2	-2.3	1.2	-0.8
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.2	1.1	0.9	-0.0	0.5
Emphysema/chronic bronchitis	0.1	0.1	0.2	-0.2	-0.4	-0.0	-0.1
Medication for pain relief, constipation, heartburn	1.2	2.1	3.8	-1.2	-1.0	1.9	-1.4
Neck or shoulder pain in last month	0.0	0.0	0.1	-0.0	-0.2	0.0	-0.3
Medication: Blood pressure	0.2	0.3	0.3	0.6	0.6	-0.5	0.5
Angina (self-reported)	4.4	5.8	9.7	2.6	1.1	-2.3	3.1
Migraine (self-reported)	0.8	1.0	2.7	-0.7	0.3	0.8	-1.6
Medication: Ibuprofen	0.9	1.0	1.4	1.1	0.8	-1.2	0.9
Medication: Allopurinol	0.4	0.6	1.5	0.5	1.2	-0.7	-0.3
Medication: Omeprazole	0.6	0.7	1.6	0.6	-0.0	-0.8	1.3
Medication: Seretide 50 evohaler	0.0	0.0	0.1	0.2	0.1	0.2	0.1
Mean time to correctly identify matches	0.7	1.4	2.8	1.7	1.2	-0.6	1.0
Heart disease (mother)	0.2	0.3	0.8	-0.4	-0.9	0.2	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.6	4.9	1.0	0.1	-2.2	0.8
Whole body fat mass	0.1	0.5	1.3	0.3	-0.8	-0.2	1.2
Leg fat mass (right)	0.2	0.8	1.8	0.2	-1.0	-0.4	1.4
Arm predicted mass (right)	0.0	0.2	0.5	0.3	0.2	-0.1	0.7
Pulse rate, automated reading	2.2	7.2	9.0	3.0	2.7	-2.9	2.1
Alcohol intake frequency.	0.7	1.7	2.5	1.5	1.6	-1.2	0.9
Comparative height size at age 10	0.2	1.2	3.5	1.1	1.9	-0.3	0.3
Number of full sisters	0.5	0.6	1.6	0.8	0.5	-1.2	0.4
Suffer from ‘nerves’	0.9	1.4	3.8	1.4	1.9	-0.3	-0.1
Overall health rating	1.1	2.4	5.9	1.9	2.4	-0.6	-0.3
Chest pain or discomfort	0.1	0.1	0.2	0.4	-0.3	-0.1	0.5
Had major operations	1.1	1.3	1.6	1.2	0.9	-1.2	1.3
Age at last live birth	1.4	2.0	3.0	1.4	1.6	-1.7	0.6
Family relationship satisfaction	1.1	1.4	2.4	-1.0	-0.4	1.6	-1.4
Leg pain on walking	1.5	1.8	4.2	-0.8	-0.1	1.6	-2.1
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.4	0.3	0.0	-0.6	0.6
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.6	0.4	-0.5	-0.9	1.6
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.2	0.7	0.4	-1.1	0.8
Medication: Aspirin	1.6	2.2	4.8	1.2	0.4	-1.5	2.2
Supplements: Vitamin C	2.1	2.5	7.6	-1.3	0.0	0.8	-2.8
Knee pain experienced in last month	0.9	1.4	2.9	0.3	1.2	1.2	-1.7
Hypertension (Self-reported)	0.5	1.3	2.8	1.3	1.7	-0.9	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	3.4	0.3	-0.7	-0.9	1.8
Illnesses of father: Heart disease	2.9	4.0	10.4	-1.9	-3.2	1.3	0.4
Illnesses of siblings: Diabetes	0.9	1.1	2.4	0.4	1.6	-0.3	-1.3
Smoking status: Previous	1.0	1.5	4.5	-0.9	-0.1	0.9	-2.1
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.5	-0.4	-0.3	0.4	-0.7
Whole body fat-free mass	0.0	0.1	0.2	0.2	0.2	0.1	0.4
Leg fat-free mass (right)	0.0	0.1	0.1	-0.0	-0.0	0.3	0.4
Arm fat percentage (left)	0.2	0.8	1.8	0.3	-1.0	-0.3	1.4
Average weekly red wine intake	0.4	0.6	1.3	-0.7	-1.2	0.4	-0.4
Handedness (chirality/laterality): Left-handed	1.5	1.8	5.2	-0.8	-0.5	2.3	-1.0
Mood swings	1.5	2.8	7.8	1.6	2.8	-0.7	-0.5
Loneliness, isolation	1.9	2.6	5.0	2.1	2.2	-1.0	0.2
Long-standing illness, disability or infirmity	1.9	2.9	5.5	2.3	2.1	-0.9	1.0
Ever had bowel cancer screening	1.0	1.2	1.6	1.3	1.2	-0.8	0.9
Diabetes diagnosed by doctor	0.9	1.5	2.7	1.6	1.1	-0.7	1.3
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	3.2	-0.9	0.1	1.3	-1.8
Friendships satisfaction	1.5	1.9	2.7	-1.4	-1.1	1.6	-1.3
Qualifications: nursing, teaching	0.5	0.8	1.0	-1.0	-0.9	0.7	-0.9
Commuting to job workplace: Walk	1.1	1.1	3.4	0.7	1.8	-0.2	-0.8
Eye problems/disorders: Cataract	0.8	1.0	1.9	1.4	1.2	-0.3	0.7
Mouth/teeth dental problems: Mouth ulcers	2.8	4.5	6.3	2.4	1.5	-1.9	2.5
Medication for cholesterol	1.7	2.6	6.4	-1.8	-2.5	1.1	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.8	3.3	4.9	2.1	2.2	-1.9	0.6
Back pain experienced in last month	0.8	1.1	3.2	0.8	1.8	-0.6	-0.5
Mineral and other dietary supplements	0.8	1.1	2.7	-0.5	-1.6	0.7	1.0
Breast cancer (self-reported)	1.0	1.2	1.8	1.3	1.3	-1.0	0.4
Asthma (self-reported)	1.2	2.4	4.9	-1.5	-0.9	1.3	-2.2
Osteoporosis (self-reported)	0.1	0.1	0.4	-0.3	-0.0	-0.7	-0.2
Osteoarthritis (self-reported)	0.1	0.1	0.2	0.4	0.1	-0.3	0.2
Medication: Aspirin	1.9	2.5	4.4	1.5	0.8	-1.6	2.1
Medication: Gliclazide	0.5	0.5	1.0	0.7	0.7	-1.0	0.1
Illnesses of father: None of the above (group 1)	2.3	2.9	5.8	1.8	2.4	-1.5	0.3
Smoking status: Current	0.5	0.9	1.5	-0.9	-1.2	1.0	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.0	-1.0	-0.2	0.7	-1.0
Whole body water mass	0.0	0.1	0.2	0.2	0.2	0.1	0.4
Leg predicted mass (right)	0.0	0.1	0.1	-0.1	-0.1	0.4	0.3
Arm fat mass (left)	0.2	0.7	1.8	0.4	-0.8	-0.2	1.3
Number of self-reported non-cancer illnesses	0.8	1.4	2.4	1.1	1.5	-0.8	-1.2
Average weekly champagne plus white wine intake	0.2	0.2	0.6	0.1	0.5	-0.8	0.2
Miserableness	3.4	5.9	10.1	3.2	3.0	-1.7	1.4
Guilty feelings	0.4	0.6	1.2	1.0	1.1	0.1	0.3
Wears glasses or contact lenses	0.2	0.3	0.6	-0.4	-0.8	-0.6	-0.3
Ever taken oral contraceptive pill	1.5	1.6	3.3	-1.2	-1.3	1.8	-0.4
Hearing aid user	0.5	0.5	0.9	0.1	-0.8	-0.8	0.9
Mother’s age at death	0.3	0.3	0.6	0.4	0.1	-0.8	0.7
Financial situation satisfaction	0.3	0.4	0.7	-0.4	0.1	0.8	-0.8
Tinnitus: Yes, now most or all of the time	0.4	0.4	0.9	-0.2	-0.9	-0.5	0.7
Commuting to job workplace: Public transport	0.1	0.2	0.3	0.2	-0.6	0.1	0.5
Eye problems/disorders: Glaucoma	0.9	1.1	2.5	1.0	1.6	-0.0	-0.8
Medication: Blood pressure	2.1	3.9	7.7	2.2	2.8	-1.7	0.3
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.7	-0.8	-0.8	0.6	-0.6
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.5	-0.3	0.8	-0.1	-1.6
High cholesterol (Self-reported)	1.3	2.3	4.1	1.5	0.7	-1.5	2.0
Medication: Bendroflumethiazide	1.0	1.6	2.2	1.5	1.2	-1.2	1.1
Medication: Paracetamol	0.1	0.1	0.3	-0.0	0.4	-0.6	-0.3
Medication: Lisinopril	0.5	0.7	1.0	0.9	1.0	-1.0	0.1
Medication: Atorvastatin	2.5	3.2	6.2	1.8	0.6	-1.6	2.5
Illnesses of father: High blood pressure	1.0	1.2	2.4	-1.5	-1.2	0.6	-0.9
Alcohol drinker status: Never	0.6	0.7	1.6	0.7	0.3	-0.8	1.3
Ever smoked	1.1	2.0	3.2	-1.2	-0.8	1.6	-1.8
Basal metabolic rate	0.0	0.1	0.3	0.2	-0.0	0.0	0.6
Leg fat percentage (left)	0.2	0.8	2.0	-0.2	-1.4	-0.4	1.0
Arm fat-free mass (left)	0.0	0.1	0.5	0.3	0.0	-0.1	0.7
Number of operations (self-reported)	1.4	2.1	4.0	1.8	2.0	-0.7	0.7
Average weekly beer plus cider intake	0.9	1.4	3.5	-0.5	0.4	1.9	-1.2
Irritability	0.2	0.4	1.4	0.2	0.3	-1.2	-0.1
Risk taking	0.7	1.1	2.2	-1.2	-0.5	0.7	-1.5
Ever had prostate specific antigen (PSA) test	0.4	0.4	0.8	0.7	0.9	0.6	0.1
Fractured/broken bones in last 5 years	0.0	0.1	0.1	-0.3	-0.3	0.2	-0.1
Age started oral contraceptive pill	0.6	0.8	1.9	0.8	0.6	-0.5	1.4
Diastolic blood pressure, automated reading	0.1	0.4	0.8	0.6	0.9	-0.6	-0.1
Ever depressed for a whole week	0.7	0.9	2.0	1.3	1.4	-0.3	-0.0
Unable to work because of sickness or disability	0.9	1.1	2.2	1.4	1.5	-0.7	0.2
Commuting to job workplace: Cycle	0.1	0.2	0.4	-0.1	0.6	0.1	-0.5
Myopia	0.1	0.1	0.3	-0.2	-0.4	0.5	0.3
Vascular/heart problems diagnosed by doctor	0.7	1.9	3.3	-1.8	-1.8	1.1	-0.3
Cholesterol lowering medication	3.8	5.6	8.2	2.7	2.9	-2.2	1.5
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	2.6	0.5	-0.4	-0.8	1.6
Pain experienced in last month	0.4	0.7	1.2	-0.3	-1.0	-0.7	1.1
Supplements: Calcium	0.3	0.4	0.5	-0.7	-0.5	-0.7	-0.5
Basal cell carcinoma (self-reported)	1.8	2.2	3.6	1.5	1.9	-1.4	1.0
Heart attack/myocardial infarction (self-reported)	0.8	1.1	1.9	1.4	0.9	-1.0	0.7
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.9	0.9	1.0	0.2	0.3
Heart disease (siblings)	0.6	0.8	2.5	0.6	1.6	-0.3	-0.5
Alcohol drinker status: Previous	0.6	0.7	1.2	0.5	1.1	-1.1	-0.1
Pack years of smoking	0.2	0.3	1.0	-0.0	0.0	1.0	-0.3
Impedance of whole body	0.0	0.2	0.5	0.5	0.7	-0.4	-0.1
Leg fat mass (left)	0.2	0.6	1.4	0.1	-1.0	-0.3	1.2
Arm predicted mass (left)	0.0	0.2	0.6	0.1	-0.2	0.1	0.8