Best TWAS P=3.29e-13 · Best GWAS P=2.42e-13 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Skin Sun Exposed Lower leg | IL20RB | 0.16 | 0.08 | lasso | 7 | 0.14 | 1.2e-11 | 3.6 | 5.2 | 1.5e-07 | 0.00 | 0.06 | 0.84 | FALSE |
| 2 | GTEx | Testis | MRAS | 0.20 | 0.14 | lasso | 4 | 0.11 | 1.2e-05 | 7.3 | -7.0 | 2.7e-12 | -0.98 | 0.02 | 0.98 | FALSE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TXNDC6 | 0.02 | 0.00 | blup | 49 | 0.00 | 1.4e-01 | 6.0 | 7.1 | 1.6e-12 | 0.94 | 0.02 | 0.82 | FALSE |
| 4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | IL20RB | 0.06 | 0.00 | enet | 20 | 0.01 | 8.8e-03 | 4.4 | 5.8 | 6.1e-09 | 0.05 | 0.00 | 0.40 | TRUE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MRAS | 0.09 | 0.08 | lasso | 4 | 0.09 | 7.2e-10 | 6.2 | -6.8 | 7.3e-12 | -0.86 | 0.30 | 0.70 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MRAS | 0.03 | 0.01 | blup | 49 | 0.01 | 9.6e-03 | 7.3 | -6.6 | 4.3e-11 | -0.94 | 0.02 | 0.87 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TXNDC6 | 0.08 | 0.05 | lasso | 1 | 0.05 | 1.5e-06 | 5.2 | -5.2 | 2.4e-07 | -0.64 | 0.97 | 0.00 | FALSE |
| 8 | The Cancer Genome Atlas | Soft Tissue Sarcoma | MRAS | 0.04 | 0.03 | blup | 49 | 0.04 | 1.8e-03 | 7.3 | 7.3 | 3.3e-13 | 0.97 | 0.02 | 0.87 | TRUE |