TWAS hub - TXNDC6

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0203	0.0174	4.1e-03	0.004	0.002	-0.001	NA	0.001	4.3e-02	1.4e-01	6.8e-01	NA	1.8e-01
2	TCGA	Brain Lower Grade Glioma	0.0848	0.0373	4.1e-05	0.053	0.048	0.049	NA	0.052	9.9e-07	3.1e-06	3.1e-06	NA	1.5e-06
3	TCGA	Thyroid Carcinoma	0.0510	0.0420	3.5e-03	0.025	0.010	0.022	NA	0.007	1.6e-03	3.0e-02	2.8e-03	NA	6.1e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Alcohol usually taken with meals	9.5	15.4	18.9	-4.3	3.0	-4.3
Medication: Ramipril	8.4	10.7	12.3	3.5	-3.5	2.8
Medication: Gliclazide	8.4	9.5	13.5	3.0	-2.4	3.7
Type 2 Diabetes (T2D) (2018)	8.1	15.2	18.8	4.3	-2.9	4.3
Long-standing illness, disability or infirmity	7.8	12.0	13.4	3.7	-3.2	3.6
Medication: Metformin	7.7	10.8	13.9	3.7	-2.2	3.7
Medication: Atenolol	7.5	9.4	19.3	2.6	-4.4	1.5
Medication: Cholesterol lowering	7.4	11.5	12.4	3.5	-3.5	3.1
Chronotype (morning person)	7.0	16.1	20.4	-4.5	3.6	-3.9
Comparative body size at age 10	6.6	18.1	30.0	5.5	-1.8	4.6
Vascular/heart problems diagnosed by doctor	6.4	17.4	21.7	-4.0	4.7	-3.9
Medication for cholesterol, blood pressure or diabetes	6.3	10.4	14.5	-3.2	2.6	-3.8
Gout (self-reported)	6.2	8.4	12.3	3.5	-0.9	3.5
Intelligence (Savage-Jansen 2018)	5.6	17.2	23.7	4.1	-4.9	3.4
Coronary Artery Disease (CAD)	5.4	6.5	8.0	2.5	-2.3	2.8
High blood pressure (mother)	5.3	7.4	9.4	2.9	-3.1	2.1
Lung FVC	5.1	26.2	34.8	-5.9	4.3	-5.0
Chronic bronchitis/emphysema (father)	5.0	5.9	8.7	-3.0	1.9	-2.4
Medication: Blood pressure	5.0	9.6	13.1	3.6	-2.9	2.7
Taking other prescription medications	4.9	7.5	12.1	2.6	-1.9	3.5
Emphysema/chronic bronchitis	4.9	5.5	8.9	2.5	-1.2	3.0
Verbal and Numeric Reasoning (VNR)	4.7	11.4	13.8	3.7	-3.2	3.2
Cardiovascular Disease	4.7	15.7	15.9	4.0	-4.0	3.9
High blood pressure	4.7	13.2	14.4	3.6	-3.5	3.8
Father’s age at death	4.7	6.3	7.2	-2.5	2.7	-2.3
Mouth/teeth dental problems: Bleeding gums	4.7	6.1	8.8	-3.0	2.2	-2.1
Diabetes (self-reported)	4.6	7.2	12.8	2.7	-1.3	3.6
Medication: Blood pressure	4.6	8.1	11.8	2.7	-2.3	3.4
Medication: Allopurinol	4.6	6.1	8.6	2.9	-1.2	2.9
Primary Biliary Cirrhosis	4.5	6.4	7.6	2.8	-2.1	2.7
Fluid intelligence score	4.4	9.2	11.8	3.4	-2.8	2.8
Diabetes diagnosed by doctor	4.3	7.1	11.9	2.6	-1.5	3.5
Had menopause	4.0	5.0	6.8	-2.3	1.7	-2.6
Falls in the last year	4.0	5.4	8.0	2.4	-2.8	1.6
Number of operations (self-reported)	4.0	5.9	7.4	-2.6	2.7	-1.9
Forced vital capacity (FVC), Best measure	3.9	14.4	21.7	-4.3	1.8	-4.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.9	8.2	13.2	-3.3	0.7	-3.6
Average weekly red wine intake	3.7	5.5	7.1	-2.7	1.9	-2.4
Number of self-reported non-cancer illnesses	3.7	6.5	8.7	2.5	-2.1	2.9
Hearing difficulty/problems: Yes	3.6	5.4	8.0	2.8	-0.7	2.8
Age at First Birth	3.5	5.0	7.7	-1.9	2.8	-1.9
Diabetes (mother)	3.5	4.5	6.1	2.5	-1.1	2.5
Multivitamins +/- minerals	3.5	4.5	7.1	-2.2	2.7	-1.3
High cholesterol (Self-reported)	3.5	6.2	7.5	2.7	-2.4	2.3
Medication: Atorvastatin	3.5	4.3	6.1	2.4	-1.1	2.5
Forced expiratory volume in 1-second (FEV1), Best measure	3.4	11.0	18.7	-3.7	0.8	-4.3
Hypertension (Self-reported)	3.4	9.4	9.8	3.0	-3.1	3.1
Forced vital capacity (FVC)	3.3	12.8	18.5	-3.9	2.2	-4.3
Deep venous thrombosis (DVT) (self-reported)	3.3	4.3	5.1	2.2	-1.7	2.2
Type 2 Diabetes (T2D) (2012)	3.1	3.6	5.0	2.2	-1.9	1.5
Blood clot in the leg (DVT)	3.0	3.9	4.9	2.2	-1.6	2.1
Osteoarthritis (self-reported)	3.0	3.9	4.5	2.0	-2.1	1.8
Illnesses of siblings: Diabetes	2.9	3.6	4.4	2.1	-1.6	2.0
Heel bone mineral density (BMD) T-score, automated (right)	2.8	6.5	9.2	-3.0	2.6	-1.9
Number of treatments/medications taken	2.7	4.9	7.3	2.1	-1.7	2.7
Forced expiratory volume in 1-second (FEV1)	2.7	9.0	14.6	-3.2	1.4	-3.8
Number of children fathered	2.7	3.0	5.4	-1.8	0.6	-2.3
Number of incorrect matches in round	2.6	4.4	7.9	-1.9	2.8	-1.3
Medication: Simvastatin	2.6	3.9	4.7	2.2	-2.1	1.5
Illnesses of mother	2.6	3.2	3.9	-2.0	2.0	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.6	3.1	6.8	1.6	0.0	2.6
Medication: Paracetamol	2.5	4.2	4.5	-1.9	2.1	-2.1
Tinnitus: Yes, now most or all of the time	2.5	2.9	3.5	1.9	-1.6	1.7
Mouth/teeth dental problems: Dentures	2.4	4.0	7.3	1.9	-0.9	2.7
Suffer from ‘nerves’	2.4	3.7	3.9	1.9	-1.9	2.0
Medication: Bendroflumethiazide	2.4	3.6	5.6	2.4	-1.6	1.6
Ever had prostate specific antigen (PSA) test	2.4	2.8	3.6	-1.9	1.7	-1.3
Hearing difficulty/problems with background noise	2.3	3.6	6.0	2.2	-0.2	2.5
Depression (self-reported)	2.3	2.8	5.4	1.7	-2.3	0.3
Breast cancer (self-reported)	2.3	2.8	4.1	-2.0	0.4	-2.0
Cholesterol lowering medication	2.3	3.3	4.9	2.2	-1.4	1.7
Number of full brothers	2.2	2.8	4.7	1.8	-0.5	2.2
Ever had stillbirth, spontaneous miscarriage or termination	2.2	2.4	4.9	-2.2	1.3	-0.8
Bipolar Disorder (2018)	2.1	3.3	5.6	2.1	0.0	2.4
Fasting Glucose	2.1	2.5	2.8	1.7	-1.5	1.5
Waist Hip Ratio (WHR)	2.1	9.3	13.7	2.6	-3.7	2.8
Loud music exposure frequency	2.1	2.3	3.9	1.7	-0.6	2.0
Medication for cholesterol	2.1	3.2	5.2	-2.3	1.5	-1.4
Age started oral contraceptive pill	2.1	2.6	3.3	-1.8	1.5	-1.4
Bipolar Disorder or Schizophrenia	2.0	4.9	8.5	2.9	-0.2	2.5
Vitamin and mineral supplements	2.0	2.8	4.5	1.6	-2.1	1.2
Worry too long after embarrassment	2.0	3.4	5.0	2.2	-1.3	1.9
Angina (self-reported)	2.0	2.6	7.3	0.5	-2.7	0.5
Medication: Omeprazole (e.g. Zanprol)	2.0	2.5	6.7	-0.6	2.6	0.5
Heel bone mineral density (BMD) T-score, automated (left)	1.9	4.4	5.9	-2.4	2.0	-1.8
Noisy workplace	1.9	2.4	3.8	-1.9	-0.2	-1.8
Peak expiratory flow (PEF)	1.9	4.5	8.6	-2.2	0.2	-2.9
Supplements: Vitamin C	1.9	2.2	3.0	-1.5	1.2	-1.7
Heel T-Score	1.8	14.1	18.8	-4.3	3.9	-2.9
Angina	1.8	2.4	6.7	0.4	-2.6	0.6
Hand grip strength (right)	1.8	4.8	7.6	-2.0	2.8	-1.7
Nervous feelings	1.8	3.4	4.8	2.2	-1.5	1.8
Heart attack	1.8	2.3	6.7	0.4	-2.6	0.3
Systolic Blood Pressure	1.7	8.5	14.7	2.4	-3.8	2.2
Medication for hormone replacement therapy	1.7	1.9	2.2	-1.5	1.2	-1.4
Pulse wave Arterial Stiffness index	1.7	2.0	3.5	-1.0	1.9	-1.2
Illness, injury, bereavement, stress in last 2 years	1.7	2.1	4.4	1.3	0.1	2.1
Bilateral oophorectomy (both ovaries removed)	1.6	1.8	3.3	-1.8	0.8	-1.2
Time employed in main current job	1.6	1.8	5.4	0.1	2.3	0.4
Hair/balding pattern: Pattern 4	1.6	3.9	7.7	-2.8	0.4	-1.9
Medication: Aspirin	1.6	2.1	5.6	0.4	-2.4	0.7
Medication: Paracetamol	1.6	2.5	3.9	-2.0	1.2	-1.5
Diastolic blood pressure, automated reading	1.6	5.1	7.3	2.3	-2.7	1.6
Heart attack/myocardial infarction (self-reported)	1.6	2.1	6.0	0.4	-2.4	0.4
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	2.6	1.2	-1.6	1.0
Fed-up feelings	1.5	2.7	4.0	2.0	-1.4	1.5
Waist circumference	1.5	5.4	8.9	3.0	-1.9	2.0
Asthma	1.5	2.9	4.9	1.8	-0.9	2.2
Medication: Aspirin	1.5	2.0	5.2	0.6	-2.3	0.7
Eye problems/disorders: Glaucoma	1.5	1.7	3.3	-1.0	1.8	-1.0
Fractured/broken bones in last 5 years	1.5	1.9	3.6	1.4	-0.3	1.9
Systolic blood pressure, automated reading	1.4	4.1	6.9	2.0	-2.6	1.2
Medication: Co-codamol	1.4	1.7	4.5	0.7	-2.1	0.3
Lung cancer (father)	1.4	1.6	3.1	-1.2	1.8	-0.5
Wheeze or whistling in the chest in last year	1.4	2.5	4.3	1.6	-2.1	0.8
Medication: Omeprazole	1.4	1.7	4.6	-0.6	2.2	0.3
Ever used hormone-replacement therapy (HRT)	1.3	1.7	3.1	-1.3	0.5	-1.8
Exposure to tobacco smoke outside home	1.3	1.7	2.7	1.3	-1.6	0.9
Pulse wave peak to peak time	1.3	1.6	3.0	0.9	-1.7	1.0
Ever smoked	1.3	2.2	5.7	-0.5	2.4	-0.9
Body Mass Index (BMI) (2010)	1.2	1.7	2.9	1.7	-1.0	1.0
Triglycerides	1.2	2.0	2.8	1.6	-0.9	1.7
Neuroticism	1.2	3.0	7.1	2.7	-1.0	0.8
Hair Pigment	1.2	33.3	49.8	7.1	-5.2	4.8
Sitting height	1.2	8.8	14.2	-3.2	1.3	-3.8
Myopia	1.2	1.7	2.6	1.4	-0.7	1.6
Blood Red Count	1.1	10.5	14.9	-3.9	2.7	-3.1
Hand grip strength (left)	1.1	2.9	4.0	-1.9	2.0	-1.1
Average weekly spirits intake	1.1	1.4	3.0	0.9	0.6	1.7
Pain all over the body in last month	1.1	1.1	3.2	0.3	-1.8	0.5
Hair/balding pattern: Pattern 3	1.1	1.6	2.8	0.3	1.4	1.7
Alcohol intake frequency.	1.1	2.6	3.4	1.8	-1.3	1.7
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	2.5	1.6	-1.2	-0.0
Qualifications: nursing, teaching	1.1	1.7	3.1	1.2	-0.8	1.8
Illnesses of father: None of the above (group 1)	1.1	1.3	3.5	0.2	0.6	1.9
Irritability	1.1	1.8	3.3	1.8	-1.2	0.8
Blood Eosinophil Count	1.0	7.8	10.8	-2.5	3.3	-2.5
Respiratory disease	1.0	2.2	4.0	1.6	-0.2	2.0
Impedance of leg (left)	1.0	4.9	8.4	-2.9	0.7	-2.4
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	1.7	1.2	-1.3	0.7
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.3	-0.7	1.5	-0.8
Ever had bowel cancer screening	1.0	1.1	2.1	-0.2	1.4	1.1
Basal cell carcinoma (self-reported)	1.0	1.2	2.9	-0.8	1.7	0.0
Impedance of whole body	1.0	5.2	8.3	-2.9	1.6	-2.2
Schizophrenia (2018)	0.9	2.0	4.3	2.1	-0.2	1.3
Alzheimer’s Disease (in mother)	0.9	1.0	1.7	1.2	0.2	1.3
Relative age voice broke	0.9	1.4	2.3	1.4	-1.5	-0.1
Illnesses of siblings	0.9	1.3	1.9	-1.4	1.3	-0.5
Neuroticism score	0.9	2.0	3.6	1.9	-1.3	0.9
Number of live births	0.9	1.3	1.8	1.1	-1.3	1.0
Breastfed as a baby	0.9	1.1	2.9	0.7	-1.7	-0.2
Headache pain in last month	0.9	1.5	3.2	-0.8	0.7	-1.8
Commuting to job workplace: Car/motor vehicle	0.9	1.0	2.4	0.7	-1.5	-0.2
Asthma (self-reported)	0.9	1.8	2.8	1.4	-0.8	1.7
Supplements: Calcium	0.9	1.0	1.2	0.8	1.0	1.1
Neuroticism (Nagel 2018)	0.8	1.8	4.7	2.2	-0.6	0.5
Height	0.8	14.5	16.5	-4.1	3.5	-3.8
Relative age of first facial hair	0.8	1.6	3.0	1.3	-1.7	-0.2
Impedance of leg (right)	0.8	3.8	5.9	-2.4	0.4	-2.3
Stomach or abdominal pain in last month	0.8	1.0	1.4	0.4	1.2	1.2
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	2.4	-0.6	-0.5	-1.5
Standing height	0.8	7.4	12.2	-2.8	1.5	-3.5
Exposure to tobacco smoke at home	0.8	0.9	1.3	0.9	-0.7	1.2
Ever highly irritable/argumentative for 2 days	0.8	0.9	1.8	1.3	-0.0	1.0
Chronic bronchitis/emphysema (mother)	0.8	1.0	2.2	0.8	0.2	1.5
High blood pressure (siblings)	0.8	1.1	2.6	0.9	-1.6	0.1
Chest pain or discomfort	0.8	1.2	2.6	-0.5	-1.6	-0.8
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.2	0.5	-1.5	0.7
Illnesses of father: High blood pressure	0.8	1.0	1.7	1.3	-1.2	0.0
Alcohol drinker status: Never	0.8	0.9	2.0	0.8	0.2	1.4
Ever depressed for a whole week	0.8	1.0	1.7	1.3	-1.1	-0.0
Depressed Affect (Nagel 2018)	0.7	1.6	3.9	2.0	-0.3	0.8
Alzheimer’s Disease (in father)	0.7	0.8	0.9	0.9	-0.8	1.0
Alzheimer’s Disease (including proxy)	0.7	1.0	1.6	1.3	0.1	1.1
HbA1C	0.7	0.7	1.3	1.0	0.2	1.1
Schizophrenia (2014)	0.7	1.5	2.7	1.6	0.2	1.4
Lung FEV1/FVC ratio	0.7	3.7	5.9	2.0	-2.4	1.1
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.2	0.6	0.1	1.5
Pack years adult smoking proportion	0.7	1.0	2.6	0.5	-1.6	0.5
Past tobacco smoking	0.7	1.3	3.7	0.2	-1.9	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.9	-0.3	0.4	-1.7
Had other major operations	0.7	0.9	2.2	-0.6	0.3	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.0	-0.7	1.0	-0.9
Overall health rating	0.7	1.6	2.6	1.6	-0.2	1.5
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.5	-1.6	0.4	0.3
Medication: Lisinopril	0.7	0.9	2.3	1.5	0.0	0.5
Unable to work because of sickness or disability	0.7	1.0	1.9	1.4	-1.0	-0.2
Depression (Nagel 2018)	0.6	0.8	2.0	0.3	0.7	-1.4
Neuroticism (2016)	0.6	0.8	1.1	0.9	0.8	1.0
Allergy or Eczema	0.6	1.5	3.9	-0.5	2.0	-0.4
Ever had hysterectomy (womb removed)	0.6	0.7	1.5	-0.7	1.2	0.3
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.2	0.7	1.1	0.4
Qualifications: CSEs or equivalent	0.6	0.8	2.1	0.5	-1.4	-0.5
Financial difficulties in last 2 years	0.6	0.8	1.4	-0.2	-1.0	-1.2
Impedance of arm (left)	0.6	3.0	3.9	-2.0	1.8	-1.4
Pulse wave reflection index	0.6	0.7	1.1	1.0	-0.9	0.4
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.2	0.9	-1.5	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.5	-0.9	0.3	-1.2
Illnesses of father: Heart disease	0.6	0.9	2.1	0.5	-1.4	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	3.0	-1.0	-0.0	-1.7
Guilty feelings	0.6	0.9	2.1	0.5	-1.4	-0.6
Ulcerative Colitis	0.5	0.8	2.1	0.1	-0.6	1.4
Blood Platelet Count	0.5	6.1	6.7	-2.6	2.4	-2.5
Trunk fat percentage	0.5	1.9	3.0	-0.8	1.7	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.8	-0.2	0.2	-1.3
Hayfever, allergic rhinitis or eczema	0.5	1.2	2.2	-0.5	1.5	-1.1
Hair/balding pattern: Pattern 2	0.5	0.6	0.8	0.8	-0.9	-0.7
Had major operations	0.5	0.6	1.2	-1.1	0.0	-0.8
Knee pain experienced in last month	0.5	0.7	1.1	1.0	-0.0	1.1
Mineral and other dietary supplements	0.5	0.7	1.1	1.0	-0.8	-0.5
Osteoporosis (self-reported)	0.5	0.7	1.0	1.0	0.4	0.9
Miserableness	0.5	0.8	0.8	0.9	-0.9	0.9
Commuting to job workplace: Public transport	0.5	0.6	1.0	0.8	-0.3	1.0
Risk taking	0.5	0.7	1.0	-0.7	-1.0	-0.8
Pain experienced in last month	0.5	0.8	1.3	-1.1	-0.5	-0.9
Smoking Status	0.4	1.0	2.5	1.6	-0.1	0.7
Tanning	0.4	4.9	8.8	-2.4	0.1	-3.0
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.6	0.1	0.4	-1.3
Age when periods started (menarche)	0.4	0.9	1.2	-1.0	0.6	-1.1
Qualifications: None of the above	0.4	0.8	1.9	-0.6	1.4	-0.2
Impedance of arm (right)	0.4	1.8	2.8	-1.7	1.3	-0.9
Alcohol intake versus 10 years previously	0.4	0.7	0.9	0.9	0.6	0.9
Pulse rate	0.4	0.7	1.9	-0.2	1.4	0.5
Glaucoma (self-reported)	0.4	0.4	0.7	-0.6	0.8	-0.5
Medication: Seretide 50 evohaler	0.4	0.5	0.8	0.9	-0.4	0.6
Heart disease (mother)	0.4	0.5	1.1	-0.5	-1.1	-0.3
Smoking status: Previous	0.4	0.6	1.6	-0.2	1.3	-0.1
Eye problems/disorders: Cataract	0.4	0.5	0.9	-0.4	1.0	0.6
Back pain experienced in last month	0.4	0.6	1.3	0.7	0.3	1.1
Hearing aid user	0.4	0.5	1.1	0.4	0.4	1.0
Worry (Nagel 2018)	0.3	0.6	1.7	1.3	0.1	0.3
Major Depression (MDD)	0.3	0.4	0.6	-0.7	0.8	-0.2
Breast Cancer	0.3	0.8	1.1	0.9	-1.1	0.6
Prostate Cancer	0.3	0.4	0.5	0.7	0.0	-0.7
HDL Cholesterol	0.3	0.6	1.0	-0.6	-0.5	-1.0
LDL Cholesterol	0.3	0.4	1.0	-1.0	0.1	-0.4
BMI	0.3	1.8	4.7	2.2	-0.7	0.5
Supplements: Zinc	0.3	0.3	0.6	0.1	0.8	0.7
Diabetes (father)	0.3	0.3	0.6	-0.0	0.8	-0.5
Townsend deprivation index at recruitment	0.3	0.5	1.1	0.4	-0.4	1.1
Average weekly fortified wine intake	0.3	0.4	0.7	-0.8	0.4	-0.5
Body mass index (BMI)	0.3	1.4	3.3	1.8	-0.3	0.8
Trunk fat mass	0.3	1.3	2.4	-0.4	1.5	-1.1
Mouth/teeth dental problems	0.3	0.5	0.9	-0.7	0.4	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.8	-0.2	0.9	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.5	-0.4	0.7	-0.7
Medication: Lansoprazole	0.3	0.4	0.7	0.2	-0.7	0.8
Length of working week for main job	0.3	0.3	1.0	0.1	1.0	-0.0
Tense / ‘highly strung’	0.3	0.5	0.9	1.0	-0.4	0.7
Birth weight	0.3	0.6	1.6	0.1	-1.3	0.6
Shortness of breath walking on level ground	0.3	0.3	0.5	0.4	-0.6	0.7
Medication: Ibuprofen	0.3	0.4	0.5	-0.7	0.5	-0.6
Pulse rate, automated reading	0.3	1.1	1.8	1.0	-0.6	1.4
Comparative height size at age 10	0.3	1.7	3.7	-0.6	1.9	-1.0
Age at last live birth	0.3	0.5	0.8	0.1	0.9	0.7
Family relationship satisfaction	0.3	0.4	0.9	1.0	-0.2	0.4
Leg pain on walking	0.3	0.4	0.7	0.6	0.9	0.1
Mood swings	0.3	0.6	1.7	1.3	-0.2	0.1
Loneliness, isolation	0.3	0.4	0.7	0.0	0.8	-0.9
Friendships satisfaction	0.3	0.4	0.9	-0.6	-0.0	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	0.8	0.9	0.2	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.8	-0.2	0.9	0.3
Pack years of smoking	0.3	0.5	0.7	0.2	-0.9	0.8
Schizophrenia vs Biploar Disorder	0.2	0.2	0.2	-0.5	0.5	-0.4
Crohns Disease (2017)	0.2	0.4	0.6	-0.5	0.6	-0.8
Ulcerative Colitis (UC)	0.2	0.4	0.5	-0.6	-0.6	0.7
Crohns Disease (2012)	0.2	0.3	0.3	-0.6	-0.6	-0.6
Lupus	0.2	0.3	0.4	-0.6	0.5	-0.5
Rheumatoid Arthritis	0.2	0.3	0.9	-0.2	0.9	0.4
Sensitivity / hurt feelings	0.2	0.4	0.8	-0.0	0.9	-0.6
Severe depression (siblings)	0.2	0.2	0.6	0.1	0.4	0.8
Current tobacco smoking	0.2	0.4	1.0	1.0	-0.2	0.1
Serious illness, injury or assault to yourself	0.2	0.2	0.4	0.6	-0.5	-0.0
Supplements: Glucosamine	0.2	0.3	0.5	-0.3	0.5	0.7
Prospective memory result	0.2	0.2	0.6	-0.7	0.0	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.4	-0.5	-0.5	-0.6
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.4	-0.2	-0.6	0.4
Body fat percentage	0.2	0.7	1.4	-0.2	1.2	-0.9
Age at first live birth	0.2	0.3	0.8	0.1	-0.1	0.9
Health satisfaction	0.2	0.2	0.4	0.4	0.4	-0.6
Medication for pain relief, constipation, heartburn	0.2	0.3	1.0	0.2	-1.0	-0.1
Neck or shoulder pain in last month	0.2	0.3	0.8	-0.0	0.9	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.4	-0.6	0.7	0.2
Smoking status: Current	0.2	0.3	0.6	0.8	0.3	-0.4
Ever taken oral contraceptive pill	0.2	0.2	0.6	-0.1	0.1	0.8
Mother’s age at death	0.2	0.2	0.4	-0.7	-0.1	-0.5
Financial situation satisfaction	0.2	0.2	0.3	0.1	0.6	-0.6
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.5	0.3	-0.7	-0.3
Commuting to job workplace: Cycle	0.2	0.3	0.7	0.3	-0.3	0.8
Alcohol drinker status: Previous	0.2	0.2	0.5	0.7	0.2	0.1
Irritable Bowel Disease (IBD)	0.1	0.3	0.8	-0.9	-0.1	-0.1
Reaction Time	0.1	0.2	0.2	0.5	-0.0	0.5
Mean Putamen Volume	0.1	0.1	0.2	-0.3	0.4	-0.1
Hypothyroidism (self reported)	0.1	0.3	0.5	-0.3	-0.5	0.7
Maternal smoking around birth	0.1	0.2	0.3	-0.5	-0.1	0.5
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.3	0.5	-0.4	0.2
Medication: Levothyroxine sodium	0.1	0.2	0.5	0.1	0.5	0.7
Allergy	0.1	0.2	0.5	-0.7	-0.2	-0.1
Weight	0.1	0.3	0.5	0.7	0.3	-0.5
Arm fat percentage (right)	0.1	0.3	0.8	0.9	0.4	0.1
Hip circumference	0.1	0.6	1.8	1.3	-0.0	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	-0.4	-0.3	-0.4
Happiness	0.1	0.2	0.4	0.7	-0.0	-0.2
Arm fat mass (right)	0.1	0.4	0.9	0.9	0.5	-0.0
Birth weight of first child	0.1	0.2	0.5	0.3	-0.7	0.1
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.2	-0.4	-0.1	0.4
Medication: Amlodipine	0.1	0.1	0.2	-0.3	-0.4	0.4
Leg fat percentage (right)	0.1	0.2	0.6	0.8	0.3	0.1
Arm fat-free mass (right)	0.1	0.4	1.1	0.2	0.1	-1.1
Eye problems/disorders: None of the above	0.1	0.1	0.3	0.0	0.1	-0.6
Migraine (self-reported)	0.1	0.1	0.3	-0.5	0.2	-0.2
Whole body fat mass	0.1	0.6	1.1	0.0	1.1	-0.8
Leg fat mass (right)	0.1	0.3	0.7	0.9	0.3	-0.1
Arm predicted mass (right)	0.1	0.7	2.0	-0.3	0.4	-1.4
Number of full sisters	0.1	0.2	0.3	0.3	-0.6	-0.2
Arm fat percentage (left)	0.1	0.4	1.0	1.0	0.5	0.2
Commuting to job workplace: Walk	0.1	0.1	0.3	-0.5	0.2	-0.2
Arm fat mass (left)	0.1	0.4	0.8	0.9	0.7	-0.0
Wears glasses or contact lenses	0.1	0.1	0.3	0.3	-0.2	-0.5
Arm fat-free mass (left)	0.1	0.3	0.8	0.1	0.1	-0.9
Leg fat mass (left)	0.1	0.2	0.5	0.7	0.5	-0.1
Arm predicted mass (left)	0.1	0.4	1.1	0.0	0.0	-1.0
Ovarian Cancer	0.0	0.0	0.1	-0.3	-0.0	0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Blood White Count	0.0	0.3	0.8	-0.0	0.1	0.9
Leg fat-free mass (left)	0.0	0.3	0.6	0.8	0.3	-0.3
Leg predicted mass (left)	0.0	0.2	0.5	0.7	0.3	-0.3
Trunk fat-free mass	0.0	0.2	0.4	0.6	-0.3	-0.5
Worrier / anxious feelings	0.0	0.1	0.2	-0.1	-0.1	-0.4
Qualifications: A levels/AS levels or equivalent	0.0	0.0	0.1	0.1	-0.2	0.1
Trunk predicted mass	0.0	0.2	0.3	0.6	-0.3	-0.5
Qualifications: College or University degree	0.0	0.1	0.1	-0.2	0.1	0.3
Mean time to correctly identify matches	0.0	0.1	0.2	0.0	0.4	0.1
Whole body fat-free mass	0.0	0.2	0.4	0.6	-0.1	-0.5
Leg fat-free mass (right)	0.0	0.2	0.6	0.8	0.2	-0.3
Whole body water mass	0.0	0.2	0.3	0.5	0.0	-0.5
Leg predicted mass (right)	0.0	0.2	0.6	0.8	0.3	-0.2
Average weekly champagne plus white wine intake	0.0	0.0	0.1	0.0	-0.1	-0.2
Basal metabolic rate	0.0	0.2	0.5	0.7	0.0	-0.5
Leg fat percentage (left)	0.0	0.2	0.3	0.4	0.5	0.0
Average weekly beer plus cider intake	0.0	0.0	0.0	0.1	0.2	-0.2
Heart disease (siblings)	0.0	0.0	0.1	0.0	0.2	-0.3

Hub : Genes

TXNDC6

Models

Trait associations