[Hub]/) : Traits : Hair Pigment :

chr11:16,072,004-19,128,224

Best TWAS P=3.22e-24 · Best GWAS P=5.15e-28 conditioned to 1.36e-19

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex C11orf58 0.14 0.14 lasso 4 0.14 4.6e-16 7.7 8.0 1.6e-15 -0.25 1.00 0.00 FALSE
2 GTEx Adipose Visceral Omentum GTF2H1 0.26 0.26 lasso 2 0.24 1.3e-12 -5.0 5.4 8.3e-08 0.09 1.00 0.00 FALSE
3 GTEx Breast Mammary Tissue (Female) GTF2H1 0.23 0.26 lasso 2 0.22 2.8e-07 -5.1 5.6 2.6e-08 0.10 0.70 0.03 FALSE
4 GTEx Cells EBV-transformed lymphocytes GTF2H1 0.42 0.12 lasso 8 0.14 2.6e-05 -5.0 5.5 4.0e-08 0.04 0.33 0.21 FALSE
5 GTEx Cells Transformed fibroblasts HPS5 0.26 0.09 lasso 7 0.11 7.1e-09 -7.4 6.5 6.9e-11 -0.04 0.00 1.00 FALSE
6 GTEx Cells Transformed fibroblasts GTF2H1 0.28 0.28 enet 9 0.30 2.2e-22 -5.1 5.8 7.6e-09 0.09 1.00 0.00 FALSE
7 GTEx Colon Transverse GTF2H1 0.21 0.20 enet 14 0.20 4.4e-10 -5.1 5.2 1.7e-07 0.10 0.97 0.02 FALSE
8 GTEx Lung GTF2H1 0.12 0.11 lasso 3 0.15 1.2e-11 -4.9 6.1 8.3e-10 0.08 0.76 0.24 FALSE
9 GTEx Muscle Skeletal HPS5 0.15 0.11 lasso 2 0.11 1.6e-10 -7.4 7.4 1.5e-13 -0.01 0.00 1.00 TRUE
10 GTEx Muscle Skeletal GTF2H1 0.10 0.01 lasso 4 0.00 2.2e-01 -4.9 6.0 1.9e-09 0.07 0.12 0.12 FALSE
11 GTEx Muscle Skeletal LDHA 0.11 0.08 enet 19 0.06 2.0e-06 -6.1 -5.3 1.3e-07 -0.01 0.71 0.29 TRUE
12 GTEx Nerve Tibial HPS5 0.10 0.04 lasso 4 0.02 1.3e-02 -6.8 7.2 6.2e-13 0.04 0.03 0.86 FALSE
13 GTEx Nerve Tibial GTF2H1 0.19 0.16 enet 11 0.19 3.1e-13 -4.9 5.2 1.9e-07 0.10 1.00 0.00 FALSE
14 GTEx Skin Not Sun Exposed Suprapubic GTF2H1 0.29 0.18 enet 12 0.24 1.4e-13 -4.9 5.8 8.3e-09 0.08 0.71 0.29 FALSE
15 GTEx Skin Sun Exposed Lower leg GTF2H1 0.15 0.16 lasso 4 0.15 2.2e-12 -5.0 5.2 1.6e-07 0.10 1.00 0.00 FALSE
16 GTEx Spleen GTF2H1 0.43 0.24 lasso 7 0.23 1.1e-06 -5.0 5.4 7.5e-08 0.09 0.75 0.06 FALSE
17 GTEx Thyroid NUCB2 0.07 0.02 lasso 4 0.02 1.3e-02 1.0 5.2 2.5e-07 -0.39 0.06 0.73 TRUE
18 GTEx Thyroid GTF2H1 0.11 0.11 lasso 5 0.08 1.9e-06 -5.1 5.2 2.1e-07 0.11 0.99 0.01 TRUE
19 METSIM Adipose GTF2H1 0.25 0.26 bslmm 454 0.27 1.2e-39 -4.9 5.2 2.1e-07 0.11 1.00 0.00 FALSE
20 NTR Blood GTF2H1 0.02 0.02 lasso 2 0.02 2.6e-06 -6.6 6.7 1.9e-11 0.04 0.33 0.67 FALSE
21 YFS Blood GTF2H1 0.10 0.11 lasso 3 0.11 1.2e-34 -6.3 6.4 1.7e-10 0.04 0.77 0.23 TRUE
22 The Cancer Genome Atlas Bladder Urothelial Carcinoma GTF2H1 0.10 0.03 enet 7 0.09 3.2e-08 -5.1 6.3 2.5e-10 0.11 0.61 0.38 FALSE
23 The Cancer Genome Atlas Breast Invasive Carcinoma HPS5 0.04 0.02 blup 72 0.01 1.5e-03 -1.6 5.2 1.5e-07 0.09 0.03 0.70 FALSE
24 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma GTF2H1 0.10 0.05 blup 63 0.05 5.7e-04 -4.9 5.5 3.1e-08 0.07 0.45 0.05 FALSE
25 The Cancer Genome Atlas Brain Lower Grade Glioma GTF2H1 0.11 0.14 lasso 6 0.16 1.2e-17 -6.1 6.2 4.6e-10 0.06 0.86 0.14 FALSE
26 The Cancer Genome Atlas Lung Adenocarcinoma GTF2H1 0.07 0.09 blup 64 0.08 1.1e-09 -4.9 5.3 1.4e-07 0.10 0.96 0.04 TRUE
27 The Cancer Genome Atlas Soft Tissue Sarcoma GTF2H1 0.09 0.08 lasso 2 0.07 4.7e-05 -4.9 5.3 1.5e-07 0.12 0.66 0.02 FALSE
28 The Cancer Genome Atlas Stomach Adenocarcinoma GTF2H1 0.12 0.12 enet 9 0.14 1.6e-10 -4.6 5.9 3.8e-09 0.09 0.94 0.06 FALSE
29 The Cancer Genome Atlas Testicular Germ Cell Tumors GTF2H1 0.12 0.01 blup 65 0.05 8.5e-03 -6.6 6.6 3.9e-11 0.08 0.03 0.26 FALSE
30 The Cancer Genome Atlas Thyroid Carcinoma C11orf58 0.05 0.04 enet 5 0.04 1.8e-04 7.7 -10.2 3.2e-24 0.46 0.08 0.42 TRUE
31 The Cancer Genome Atlas Thyroid Carcinoma SAA1 0.04 0.01 blup 58 0.01 5.5e-02 5.2 5.3 1.2e-07 -0.07 0.03 0.27 FALSE