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chr11:16,072,004-19,128,224

Best TWAS P=3.22e-24 · Best GWAS P=5.15e-28 conditioned to 1.36e-19

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	C11orf58	0.14	0.14	lasso	4	0.14	4.6e-16	7.7	8.0	1.6e-15	-0.25	1.00	0.00	FALSE
2	GTEx	Adipose Visceral Omentum	GTF2H1	0.26	0.26	lasso	2	0.24	1.3e-12	-5.0	5.4	8.3e-08	0.09	1.00	0.00	FALSE
3	GTEx	Breast Mammary Tissue (Female)	GTF2H1	0.23	0.26	lasso	2	0.22	2.8e-07	-5.1	5.6	2.6e-08	0.10	0.70	0.03	FALSE
4	GTEx	Cells EBV-transformed lymphocytes	GTF2H1	0.42	0.12	lasso	8	0.14	2.6e-05	-5.0	5.5	4.0e-08	0.04	0.33	0.21	FALSE
5	GTEx	Cells Transformed fibroblasts	HPS5	0.26	0.09	lasso	7	0.11	7.1e-09	-7.4	6.5	6.9e-11	-0.04	0.00	1.00	FALSE
6	GTEx	Cells Transformed fibroblasts	GTF2H1	0.28	0.28	enet	9	0.30	2.2e-22	-5.1	5.8	7.6e-09	0.09	1.00	0.00	FALSE
7	GTEx	Colon Transverse	GTF2H1	0.21	0.20	enet	14	0.20	4.4e-10	-5.1	5.2	1.7e-07	0.10	0.97	0.02	FALSE
8	GTEx	Lung	GTF2H1	0.12	0.11	lasso	3	0.15	1.2e-11	-4.9	6.1	8.3e-10	0.08	0.76	0.24	FALSE
9	GTEx	Muscle Skeletal	HPS5	0.15	0.11	lasso	2	0.11	1.6e-10	-7.4	7.4	1.5e-13	-0.01	0.00	1.00	TRUE
10	GTEx	Muscle Skeletal	GTF2H1	0.10	0.01	lasso	4	0.00	2.2e-01	-4.9	6.0	1.9e-09	0.07	0.12	0.12	FALSE
11	GTEx	Muscle Skeletal	LDHA	0.11	0.08	enet	19	0.06	2.0e-06	-6.1	-5.3	1.3e-07	-0.01	0.71	0.29	TRUE
12	GTEx	Nerve Tibial	HPS5	0.10	0.04	lasso	4	0.02	1.3e-02	-6.8	7.2	6.2e-13	0.04	0.03	0.86	FALSE
13	GTEx	Nerve Tibial	GTF2H1	0.19	0.16	enet	11	0.19	3.1e-13	-4.9	5.2	1.9e-07	0.10	1.00	0.00	FALSE
14	GTEx	Skin Not Sun Exposed Suprapubic	GTF2H1	0.29	0.18	enet	12	0.24	1.4e-13	-4.9	5.8	8.3e-09	0.08	0.71	0.29	FALSE
15	GTEx	Skin Sun Exposed Lower leg	GTF2H1	0.15	0.16	lasso	4	0.15	2.2e-12	-5.0	5.2	1.6e-07	0.10	1.00	0.00	FALSE
16	GTEx	Spleen	GTF2H1	0.43	0.24	lasso	7	0.23	1.1e-06	-5.0	5.4	7.5e-08	0.09	0.75	0.06	FALSE
17	GTEx	Thyroid	NUCB2	0.07	0.02	lasso	4	0.02	1.3e-02	1.0	5.2	2.5e-07	-0.39	0.06	0.73	TRUE
18	GTEx	Thyroid	GTF2H1	0.11	0.11	lasso	5	0.08	1.9e-06	-5.1	5.2	2.1e-07	0.11	0.99	0.01	TRUE
19	METSIM	Adipose	GTF2H1	0.25	0.26	bslmm	454	0.27	1.2e-39	-4.9	5.2	2.1e-07	0.11	1.00	0.00	FALSE
20	NTR	Blood	GTF2H1	0.02	0.02	lasso	2	0.02	2.6e-06	-6.6	6.7	1.9e-11	0.04	0.33	0.67	FALSE
21	YFS	Blood	GTF2H1	0.10	0.11	lasso	3	0.11	1.2e-34	-6.3	6.4	1.7e-10	0.04	0.77	0.23	TRUE
22	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	GTF2H1	0.10	0.03	enet	7	0.09	3.2e-08	-5.1	6.3	2.5e-10	0.11	0.61	0.38	FALSE
23	The Cancer Genome Atlas	Breast Invasive Carcinoma	HPS5	0.04	0.02	blup	72	0.01	1.5e-03	-1.6	5.2	1.5e-07	0.09	0.03	0.70	FALSE
24	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	GTF2H1	0.10	0.05	blup	63	0.05	5.7e-04	-4.9	5.5	3.1e-08	0.07	0.45	0.05	FALSE
25	The Cancer Genome Atlas	Brain Lower Grade Glioma	GTF2H1	0.11	0.14	lasso	6	0.16	1.2e-17	-6.1	6.2	4.6e-10	0.06	0.86	0.14	FALSE
26	The Cancer Genome Atlas	Lung Adenocarcinoma	GTF2H1	0.07	0.09	blup	64	0.08	1.1e-09	-4.9	5.3	1.4e-07	0.10	0.96	0.04	TRUE
27	The Cancer Genome Atlas	Soft Tissue Sarcoma	GTF2H1	0.09	0.08	lasso	2	0.07	4.7e-05	-4.9	5.3	1.5e-07	0.12	0.66	0.02	FALSE
28	The Cancer Genome Atlas	Stomach Adenocarcinoma	GTF2H1	0.12	0.12	enet	9	0.14	1.6e-10	-4.6	5.9	3.8e-09	0.09	0.94	0.06	FALSE
29	The Cancer Genome Atlas	Testicular Germ Cell Tumors	GTF2H1	0.12	0.01	blup	65	0.05	8.5e-03	-6.6	6.6	3.9e-11	0.08	0.03	0.26	FALSE
30	The Cancer Genome Atlas	Thyroid Carcinoma	C11orf58	0.05	0.04	enet	5	0.04	1.8e-04	7.7	-10.2	3.2e-24	0.46	0.08	0.42	TRUE
31	The Cancer Genome Atlas	Thyroid Carcinoma	SAA1	0.04	0.01	blup	58	0.01	5.5e-02	5.2	5.3	1.2e-07	-0.07	0.03	0.27	FALSE