Hub : Genes

HPS5

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.2580	0.0550	3.3e-07	0.093	NA	0.112	NA	0.114	1.8e-07	NA	9.4e-09	NA	7.1e-09
2	GTEx	Lung	0.0969	0.0309	5.4e-04	0.083	NA	0.074	NA	0.076	6.9e-07	NA	2.7e-06	NA	2.0e-06
3	GTEx	Muscle Skeletal	0.1522	0.0472	1.5e-04	0.111	NA	0.075	NA	0.106	4.9e-11	NA	8.5e-08	NA	1.6e-10
4	GTEx	Nerve Tibial	0.0987	0.0423	8.4e-03	0.038	NA	0.006	NA	0.020	1.0e-03	NA	1.1e-01	NA	1.3e-02
5	GTEx	Whole Blood	0.1180	0.0400	8.4e-04	0.012	NA	0.031	NA	0.012	2.3e-02	NA	6.9e-04	NA	2.3e-02
6	TCGA	Breast Invasive Carcinoma	0.0374	0.0183	5.3e-04	0.018	0.012	0.011	NA	0.010	1.2e-04	1.5e-03	1.9e-03	NA	2.5e-03
7	TCGA	Head and Neck Squamous Cell Carcinoma	0.0329	0.0171	4.3e-03	0.000	0.013	0.000	NA	0.000	3.5e-01	1.0e-02	2.8e-01	NA	2.9e-01
8	TCGA	Kidney Renal Clear Cell Carcinoma	0.0936	0.0386	2.0e-05	0.032	0.047	0.049	NA	0.052	1.4e-04	4.9e-06	3.1e-06	NA	1.7e-06
9	TCGA	Lung Adenocarcinoma	0.0351	0.0197	8.2e-03	0.022	0.023	0.014	NA	0.020	1.1e-03	8.2e-04	7.8e-03	NA	2.0e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Bipolar Disorder (2018)	3.1	4.8	15.9	-2.2	0.1	-2.1	-2.2	-1.1	0.3	-0.3	-4.0	-3.5
Bipolar Disorder or Schizophrenia	1.8	4.3	14.0	-1.9	-0.3	-1.3	-2.4	-0.4	0.8	-1.5	-3.7	-3.3
Depressed Affect (Nagel 2018)	2.2	4.7	9.5	3.0	0.7	3.1	1.2	2.3	3.0	2.3	0.3	1.3
Depression (Nagel 2018)	0.3	0.5	2.2	0.4	0.3	0.7	-0.5	0.5	0.7	-0.2	-1.5	-0.3
Intelligence (Savage-Jansen 2018)	0.6	1.8	6.1	0.3	-2.5	0.8	2.4	-1.0	0.7	1.2	0.9	0.3
Neuroticism (Nagel 2018)	1.1	2.7	5.9	2.4	0.9	2.4	0.6	2.0	1.9	1.6	-0.4	0.7
Schizophrenia (2018)	0.6	1.3	3.3	-0.7	-0.5	0.0	-1.2	0.5	0.8	-1.7	-1.6	-1.8
Schizophrenia vs Biploar Disorder	0.7	0.9	4.7	1.1	0.7	0.6	0.7	0.0	-0.3	-0.6	0.9	2.2
Worry (Nagel 2018)	0.6	1.4	4.1	0.6	2.0	0.2	-1.5	2.0	-0.2	0.2	-1.2	0.4
Alzheimer’s Disease (in mother)	1.2	1.4	4.0	-1.0	-1.9	-0.3	0.4	-1.1	-0.9	-0.6	-1.0	-2.0
Alzheimer’s Disease (in father)	1.0	1.1	2.7	1.1	-0.7	1.1	1.6	-0.5	0.6	0.9	1.2	1.2
Alzheimer’s Disease (including proxy)	1.2	1.7	7.3	0.7	-1.9	1.6	2.7	-0.4	0.3	0.8	0.9	-0.0
Crohns Disease (2017)	0.2	0.5	1.1	-0.8	0.4	-0.6	-1.0	-0.4	0.5	-0.7	1.0	0.3
Irritable Bowel Disease (IBD)	0.2	0.6	1.6	-0.7	0.6	-0.4	-0.9	0.1	1.3	-0.1	1.2	0.2
Ulcerative Colitis (UC)	0.3	0.5	1.5	-0.7	0.4	-0.4	-0.9	0.7	1.2	0.0	0.4	-0.6
Major Depression (MDD)	0.6	0.7	2.5	1.0	0.2	1.3	0.4	-0.3	0.5	0.4	1.6	1.0
Reaction Time	2.0	3.7	17.4	-0.6	-4.2	0.0	2.7	-1.3	1.0	-0.5	1.4	-1.8
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.6	0.7	-0.7	0.4	1.6	0.7	-0.8	0.5	1.3	1.4
Breast Cancer	0.6	1.5	2.8	0.9	-1.7	1.2	1.6	1.2	1.2	0.3	1.6	0.9
Ovarian Cancer	0.4	0.5	1.2	0.6	-0.7	0.7	1.0	-1.1	0.0	0.8	-0.4	0.0
Prostate Cancer	0.8	1.2	6.2	-0.2	-2.5	0.5	1.7	-0.8	0.3	0.0	0.1	-0.7
Age at First Birth	0.9	1.3	3.6	0.8	0.3	0.3	-0.4	1.9	1.9	0.7	1.2	1.3
Bipolar Disorder (2011)	2.3	2.2	3.4	1.7	1.4	1.6	-0.2	1.8	1.8	1.7	-1.6	0.1
Body Mass Index (BMI) (2010)	0.7	1.0	3.7	0.6	-1.5	0.7	1.9	-0.8	0.9	0.8	0.4	0.1
Coronary Artery Disease (CAD)	0.9	1.1	6.0	-0.5	0.3	-0.0	-0.8	0.5	-2.5	-1.7	0.3	-0.2
Crohns Disease (2012)	0.1	0.2	0.4	0.3	0.6	0.3	-0.4	-0.5	0.4	-0.0	0.6	0.4
Mean Putamen Volume	2.4	2.7	7.3	-2.1	-0.5	-1.4	-2.4	-0.6	0.0	-2.7	-0.7	-2.0
Fasting Glucose	0.4	0.4	1.3	0.3	1.1	-0.4	-0.3	0.7	-0.6	0.4	0.3	1.1
HbA1C	0.3	0.4	1.8	0.4	-0.6	0.6	1.3	-0.1	-0.6	-0.0	-0.3	-0.5
HDL Cholesterol	0.7	1.1	3.1	0.4	1.8	-0.0	-1.2	0.3	-1.0	-0.6	0.8	1.8
LDL Cholesterol	1.5	2.4	4.6	2.1	2.0	1.4	-1.0	1.8	0.6	1.5	-0.7	2.0
Lupus	0.3	0.5	1.8	0.7	0.3	1.0	-0.1	-0.5	0.3	-0.7	-1.3	0.2
Neuroticism (2016)	2.2	3.2	8.5	2.2	-0.3	2.2	2.1	1.3	2.9	1.8	0.8	0.8
Primary Biliary Cirrhosis	2.7	3.8	12.3	-0.3	3.0	0.1	-3.5	-0.3	-1.0	-1.4	-3.1	-0.4
Rheumatoid Arthritis	0.2	0.3	1.4	0.2	-0.5	0.7	0.1	-0.1	1.2	-0.3	-0.3	-0.3
Schizophrenia (2014)	0.4	1.0	3.0	-0.7	-0.8	0.1	-0.6	-0.0	1.3	-1.2	-1.1	-1.7
Triglycerides	0.3	0.5	1.8	0.3	-1.4	0.3	1.4	0.1	0.1	0.6	-0.6	-0.3
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.8	-0.3	-0.5	0.1	0.3	-0.5	-0.1	-0.2	-1.0	-1.3
Ulcerative Colitis	0.1	0.2	0.6	-0.7	0.0	-0.4	-0.5	0.1	0.3	-0.6	-0.1	-0.8
Blood Eosinophil Count	1.0	8.0	15.4	3.6	-1.7	3.9	3.9	1.4	2.4	3.3	1.6	2.0
Blood Platelet Count	0.7	8.7	14.7	3.5	-1.3	3.6	3.8	0.9	1.7	2.4	3.6	3.6
Blood Red Count	0.5	4.8	10.8	1.9	-0.3	1.0	3.0	1.5	1.6	3.3	3.0	2.0
Blood White Count	0.6	4.8	13.9	1.8	3.2	0.7	-0.6	3.7	-0.8	1.5	1.8	2.9
Heel T-Score	0.4	3.2	11.4	-2.2	-1.0	-1.4	-0.8	-3.4	0.5	-1.9	-1.4	-1.8
BMI	1.4	8.4	22.6	3.2	-1.5	2.7	4.8	1.5	2.6	3.8	2.5	2.2
Height	0.4	7.1	18.1	0.5	-4.3	1.4	3.6	-4.1	3.1	0.8	1.5	-0.9
Waist Hip Ratio (WHR)	0.9	4.0	12.6	-0.5	3.5	-1.1	-3.1	2.5	-2.1	-0.2	-1.0	0.9
Systolic Blood Pressure	0.2	1.0	2.8	-0.4	1.7	-1.0	-0.9	0.3	-0.9	-0.3	1.0	1.6
Smoking Status	1.5	3.7	11.6	-1.4	2.4	-1.2	-3.4	-0.6	-1.6	-2.0	-2.1	-0.9
Allergy or Eczema	0.5	1.2	2.3	1.2	-0.0	1.1	0.8	1.1	0.9	1.2	1.5	1.5
Cardiovascular Disease	0.1	0.2	0.7	0.4	0.1	0.4	0.3	-0.5	-0.9	0.2	0.0	0.5
Hypothyroidism (self reported)	0.4	1.0	2.6	1.1	-0.8	1.6	1.2	-0.6	0.3	0.4	-1.4	-0.4
Respiratory disease	1.1	2.5	4.7	2.1	0.6	1.5	1.7	0.2	1.2	2.0	1.8	2.2
Type 2 Diabetes (T2D) (2018)	0.7	1.3	5.1	-1.2	-0.5	-0.8	-0.8	-0.4	-2.3	-1.7	0.2	-0.4
Lung FEV1/FVC ratio	0.5	2.3	5.4	-1.2	-0.6	-0.3	-1.6	-0.2	-1.0	-2.3	-2.3	-2.2
Lung FVC	0.4	2.1	5.0	1.0	-1.8	0.9	2.2	0.2	2.2	1.7	0.4	0.9
Neuroticism	0.4	1.1	2.8	1.3	1.1	1.0	0.3	1.7	1.1	0.9	0.5	0.9
Chronotype (morning person)	2.1	4.9	15.9	1.3	-4.0	1.9	3.7	-0.7	2.0	0.5	2.0	-0.4
Hair Pigment	0.9	26.5	54.6	6.5	-3.3	7.4	7.2	1.6	5.2	4.6	4.2	3.1
Tanning	0.5	5.6	14.4	-2.6	2.6	-2.7	-3.8	-0.5	-2.3	-2.1	-2.1	-1.0
Hand grip strength (left)	0.3	0.8	2.1	0.1	1.0	0.7	-1.1	-1.5	-0.9	-0.9	-0.5	0.3
Number of treatments/medications taken	1.3	2.4	6.7	1.1	2.6	0.6	-1.1	1.5	-2.2	-0.8	-1.8	1.0
Average weekly spirits intake	1.6	2.0	5.6	-0.1	2.4	-0.8	-2.1	1.2	-2.0	-0.5	-0.8	1.1
Sensitivity / hurt feelings	0.3	0.4	2.0	-0.0	-0.3	0.2	0.3	0.4	-0.4	-0.1	-1.4	-1.2
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.9	-0.1	1.0	-0.2	-0.6	0.5	0.7	0.2	-0.8	-0.1
Hearing difficulty/problems: Yes	0.3	0.4	1.3	0.6	1.1	0.6	-0.4	0.4	0.5	0.6	-0.3	0.9
Relative age of first facial hair	0.4	0.8	1.8	-0.9	-1.1	-0.6	0.1	-1.3	0.3	-1.1	0.1	-1.1
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.7	0.3	-0.6	0.3	0.9	-1.3	0.3	0.4	-0.1	-0.1
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.9	1.1	-0.0	0.5	1.3	-0.2	0.0	1.4	0.9	1.1
Ever had hysterectomy (womb removed)	0.7	0.8	3.2	0.6	1.3	-0.1	-0.2	0.4	0.1	0.7	1.2	1.8
Systolic blood pressure, automated reading	0.7	2.1	8.2	1.4	2.3	0.5	-0.2	1.4	-0.4	0.9	0.7	2.9
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	2.9	-0.2	-0.7	0.5	0.0	-0.3	-0.5	-1.7	-0.3	-0.4
Angina	1.6	2.1	5.0	-1.3	1.8	-1.8	-1.7	-0.2	-2.2	-0.8	-1.4	-0.2
Medication for hormone replacement therapy	0.6	0.7	2.2	1.2	1.5	0.5	-0.2	0.3	-1.0	-0.1	-0.5	1.2
Vitamin and mineral supplements	0.9	1.3	3.1	-1.0	1.1	-1.3	-1.8	0.3	-0.6	-0.7	-1.7	-0.5
Supplements: Zinc	1.1	1.2	3.0	1.1	-0.9	1.3	1.4	-0.9	1.7	0.9	0.6	-0.2
Medication: Co-codamol	1.6	1.8	5.4	0.2	1.5	0.5	-1.6	1.9	-1.3	-1.1	-2.3	-0.2
Medication: Metformin	1.7	2.4	5.2	-1.7	-1.5	-0.5	-0.6	-2.3	-1.1	-2.1	-0.6	-2.2
Diabetes (father)	1.2	1.4	3.9	-0.2	-1.6	-0.3	1.9	-1.4	0.4	0.8	2.0	0.3
Diabetes (mother)	0.7	0.9	4.3	-0.3	-0.1	-1.1	0.7	-0.6	-2.1	0.9	0.7	0.8
Severe depression (siblings)	0.5	0.5	1.7	-0.7	0.2	-0.2	-0.8	-0.6	-0.0	-0.9	-1.3	-0.8
Pack years adult smoking proportion	1.2	1.8	5.5	-0.5	2.3	-0.8	-2.3	0.2	-0.6	-0.7	-1.9	0.4
Impedance of leg (right)	1.8	8.6	16.6	-3.5	1.4	-3.5	-4.1	-1.3	-3.2	-3.1	-2.4	-2.6
Leg fat-free mass (left)	1.1	6.0	13.9	2.6	-1.7	2.7	3.7	-0.1	3.2	2.7	1.9	1.5
Trunk fat percentage	1.0	4.2	8.6	2.9	0.3	2.6	2.5	1.4	1.3	2.8	0.0	2.2
Hand grip strength (right)	0.2	0.6	1.7	0.3	1.0	0.7	-1.0	-1.3	-0.1	-0.8	-0.2	0.5
Townsend deprivation index at recruitment	3.2	4.5	9.6	-1.5	2.6	-2.0	-2.6	-1.2	-2.7	-1.2	-3.1	-0.6
Current tobacco smoking	4.2	6.9	19.2	-2.0	2.9	-1.9	-4.4	-0.1	-3.5	-3.0	-2.3	-0.7
Average weekly fortified wine intake	0.3	0.3	0.9	-0.4	-0.8	0.0	0.3	-1.0	-0.1	-0.7	-0.4	-0.8
Maternal smoking around birth	4.0	5.7	10.5	-2.6	1.3	-2.2	-3.2	-1.4	-1.9	-2.4	-3.2	-2.4
Fed-up feelings	2.0	3.7	7.7	2.8	1.8	2.6	0.5	2.1	2.0	1.6	0.3	2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.7	0.8	0.5	1.1	-0.3	1.1	1.3	-0.5	-0.5	0.2
Relative age voice broke	1.0	1.5	3.6	-0.5	-1.9	-0.3	1.6	-1.8	1.6	0.7	0.3	-0.7
Taking other prescription medications	2.0	3.0	8.9	0.4	3.0	0.0	-2.1	0.6	-2.1	-0.6	-2.9	0.4
Age when periods started (menarche)	0.7	1.8	4.3	-1.4	0.4	-1.4	-1.3	-2.1	-1.1	-0.3	-1.8	-1.2
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	3.9	0.4	1.6	-0.4	-0.1	2.0	0.4	0.8	0.3	1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	3.1	-0.4	0.0	-0.0	0.0	-1.8	-0.4	-1.1	-1.0	-0.0
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.4	-1.0	0.1	-0.8	-0.8	0.5	-1.2	-0.7	-1.0	-1.1
Qualifications: CSEs or equivalent	1.7	2.2	4.4	-1.9	0.2	-1.4	-2.1	-1.4	-0.0	-1.8	-1.5	-1.7
Serious illness, injury or assault to yourself	0.4	0.5	1.0	-0.3	1.0	-0.9	-0.4	1.0	-0.8	0.1	-0.7	0.1
High blood pressure	0.2	0.4	1.2	-0.5	0.8	-0.8	-1.1	-0.0	-0.6	-0.4	-0.7	-0.4
Hayfever, allergic rhinitis or eczema	1.5	3.3	6.2	2.4	1.0	2.0	1.0	1.5	1.4	1.9	1.9	2.5
Multivitamins +/- minerals	2.0	2.6	6.8	1.5	-0.7	1.4	2.3	0.2	1.0	1.5	2.6	1.8
Stomach or abdominal pain in last month	1.2	1.5	6.5	-0.1	2.6	-0.5	-2.1	0.4	-1.0	0.0	-1.3	0.2
Supplements: Glucosamine	0.6	0.8	3.0	-0.4	-1.7	-0.1	1.3	-0.4	-0.5	-0.2	-0.9	-1.0
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.8	-0.9	0.2	-0.8	-1.0	1.4	-1.0	-0.7	-0.5	-0.4
Medication: Atenolol	0.2	0.3	1.8	0.0	0.2	-0.2	-0.0	-0.5	-0.4	0.1	-1.3	-0.4
Medication: Levothyroxine sodium	0.7	1.3	4.1	1.7	0.4	2.0	0.9	0.6	0.4	1.0	-1.0	0.9
Sitting height	0.6	3.9	9.5	1.2	-2.5	1.5	3.1	-0.6	2.3	1.1	3.0	0.5
Chronic bronchitis/emphysema (father)	1.7	2.0	5.2	-0.6	2.3	-0.9	-2.3	-0.4	-2.0	-1.0	-1.3	0.3
High blood pressure (mother)	0.9	1.2	2.9	1.3	0.3	1.0	0.8	1.4	1.0	1.7	1.2	0.6
Body mass index (BMI)	2.0	8.7	16.4	4.0	-0.6	3.8	4.0	1.6	2.9	3.8	0.9	2.4
Impedance of leg (left)	1.6	7.8	17.1	-3.2	1.6	-3.1	-4.1	-1.1	-3.1	-3.2	-2.3	-1.9
Leg predicted mass (left)	1.1	6.0	13.8	2.6	-1.7	2.8	3.7	-0.2	3.1	2.7	1.9	1.5
Trunk fat mass	1.2	5.3	10.5	3.1	-0.4	2.9	3.2	0.9	2.0	3.1	0.4	1.9
Waist circumference	1.1	4.1	8.8	2.7	-0.2	2.8	2.4	1.1	1.7	3.0	0.2	1.5
Number of incorrect matches in round	0.5	0.9	2.6	-0.8	-0.9	-0.4	-0.4	-1.6	-1.1	-1.2	0.4	-0.8
Past tobacco smoking	0.6	1.0	4.2	0.7	-2.0	1.2	1.6	0.4	0.6	0.4	0.4	-0.1
Alcohol usually taken with meals	0.7	1.1	3.3	0.6	-1.2	0.7	1.8	0.0	0.2	1.1	1.6	0.2
Nervous feelings	0.2	0.4	1.0	-0.7	0.3	-0.7	-0.8	1.0	-0.5	-0.6	0.6	-0.5
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	8.4	1.8	-0.3	2.5	0.7	0.6	2.9	1.5	-0.4	-0.0
Hearing difficulty/problems with background noise	0.5	0.8	3.3	0.2	-1.8	0.8	1.3	0.3	0.4	0.8	-0.2	-0.9
Hair/balding pattern: Pattern 2	1.0	1.3	4.5	1.4	-0.4	1.6	0.8	-0.3	2.1	1.1	-0.6	-0.0
Had menopause	0.3	0.4	0.7	0.8	-0.4	0.8	0.6	0.6	0.2	-0.3	0.6	0.8
Had other major operations	0.8	1.0	2.5	-1.1	-1.0	-0.9	-0.2	-1.4	-0.2	-1.3	-0.2	-1.6
Forced vital capacity (FVC)	0.5	2.1	5.2	0.4	-1.8	0.7	2.1	-1.7	2.3	1.0	1.1	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	4.8	-0.7	-0.8	-0.0	0.2	-2.2	-0.4	-1.3	-1.6	-0.7
Ever unenthusiastic/disinterested for a whole week	1.4	1.7	6.0	-0.8	1.2	-0.8	-1.4	0.4	-1.8	0.2	-2.5	-0.8
Qualifications: None of the above	1.4	3.1	8.0	-1.3	2.7	-1.8	-2.8	0.1	-2.1	-0.7	-1.6	-0.2
Financial difficulties in last 2 years	1.3	1.8	4.3	-1.1	1.8	-1.2	-2.1	0.1	-1.3	-2.0	-0.5	-0.0
Mouth/teeth dental problems	0.3	0.5	2.2	0.4	0.0	0.1	0.9	-0.0	0.2	1.5	1.1	0.6
Heart attack	0.9	1.2	3.9	-0.4	0.3	-0.3	-0.1	-0.2	-2.0	0.3	-1.8	-1.7
Allergy	1.0	2.4	5.9	-1.8	-1.7	-1.4	-0.2	-0.9	-0.7	-1.2	-2.1	-2.4
Pain all over the body in last month	0.4	0.5	1.0	-0.7	0.7	-1.0	-0.9	0.7	-0.3	-0.8	0.1	-0.5
Diabetes (self-reported)	1.3	2.1	6.3	-1.3	-0.3	-0.4	-1.3	-0.9	-2.1	-2.5	-1.1	-1.4
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.7	1.6	-0.2	1.6	0.7	0.4	0.8	0.8	0.2	0.6
Medication: Ramipril	0.3	0.4	1.2	0.6	0.3	0.4	-0.0	0.8	-0.4	0.5	-1.1	-0.6
Medication: Simvastatin	1.5	2.2	8.8	0.5	3.0	-0.4	-1.3	1.0	-2.3	-0.9	-0.8	1.3
Fluid intelligence score	0.2	0.4	1.6	-0.1	-0.7	-0.2	1.1	-0.0	-1.3	0.2	0.6	0.6
Illnesses of siblings	0.9	1.3	3.3	1.2	-0.8	1.8	1.2	0.5	1.7	0.5	0.9	0.9
Neuroticism score	0.3	0.6	1.9	0.7	1.2	0.4	-0.1	1.4	0.2	0.7	0.0	0.7
Weight	1.5	7.5	16.9	3.2	-1.6	3.5	4.1	0.0	3.2	3.4	1.2	1.6
Impedance of arm (right)	0.9	4.2	11.7	-2.1	1.9	-2.5	-3.4	-0.2	-2.4	-2.1	-0.9	-0.5
Arm fat percentage (right)	1.4	5.6	11.4	3.2	0.0	2.8	2.9	1.6	2.2	3.4	0.2	2.2
Trunk fat-free mass	0.9	5.1	12.7	1.4	-2.9	2.0	3.6	-1.7	3.0	2.1	1.6	0.1
Hip circumference	1.6	7.0	16.5	3.2	-1.9	3.6	4.1	-0.7	2.8	3.0	0.7	1.3
Time employed in main current job	0.3	0.3	0.9	0.3	-0.2	0.7	0.1	-0.7	0.9	0.3	-0.6	0.2
Alcohol intake versus 10 years previously	0.4	0.6	1.3	-0.9	-0.4	-0.7	-0.2	-0.9	-0.3	-1.1	-1.0	-1.1
Father’s age at death	1.6	2.1	4.7	1.0	-1.9	1.0	2.2	0.1	1.6	1.0	2.1	0.8
Worrier / anxious feelings	0.3	0.6	2.0	0.8	-0.5	1.4	0.7	0.2	1.2	0.3	-0.3	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.7	0.4	1.1	0.3	-1.2	1.2	0.3	-0.4	-1.3	-0.2
Falls in the last year	2.4	3.3	6.7	-2.1	0.2	-1.9	-1.9	-0.6	-2.5	-2.6	-1.0	-1.8
Hair/balding pattern: Pattern 3	0.2	0.3	2.2	-0.2	0.3	-0.5	0.4	0.2	-1.5	-0.1	-0.0	0.4
Number of live births	0.8	1.1	2.5	0.8	-0.8	0.3	1.5	0.9	1.6	1.5	0.3	0.3
Forced expiratory volume in 1-second (FEV1)	0.6	2.2	5.4	0.2	-2.3	0.8	2.1	-1.7	2.2	0.6	0.9	-0.2
Pulse rate	0.5	0.9	3.5	-0.6	1.9	-1.0	-1.4	0.3	0.1	-0.4	0.7	0.7
Happiness	0.2	0.3	1.1	0.0	0.1	0.4	-0.6	0.4	1.1	0.2	-0.6	-0.3
Noisy workplace	0.7	0.9	2.4	1.0	1.6	0.8	-0.5	1.2	0.7	0.6	-0.9	0.8
Qualifications: A levels/AS levels or equivalent	2.2	4.9	15.1	1.8	-1.1	1.4	2.6	1.9	2.6	1.6	3.9	1.8
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.9	0.5	0.9	0.9	-0.7	0.2	0.3	-0.8	-0.1	0.2
Mouth/teeth dental problems: Dentures	0.4	0.6	1.9	0.9	0.5	0.9	-0.1	1.4	0.1	-0.0	-0.4	1.3
Asthma	0.5	1.0	3.1	1.0	1.5	0.3	-0.2	0.8	0.3	0.8	0.9	1.8
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.8	-0.1	-0.1	-0.0	-0.0	-0.5	0.9	0.6	-0.4	-0.5
Medication: Cholesterol lowering	0.6	0.9	3.1	0.8	1.4	-0.1	0.6	0.5	-1.8	0.8	-0.3	0.9
Depression (self-reported)	0.6	0.7	3.6	0.1	0.9	0.3	-1.2	0.4	-0.5	-0.5	-1.9	-0.6
Medication: Lansoprazole	0.5	0.6	3.0	0.4	1.7	0.1	-0.8	0.1	-0.4	0.9	-0.1	0.3
Prospective memory result	3.7	4.5	11.1	2.3	-1.9	2.3	3.0	1.3	3.3	1.2	1.5	1.1
Lung cancer (father)	2.8	3.2	9.5	-0.9	3.1	-2.0	-2.8	0.7	-2.0	-0.7	-1.2	0.6
Illnesses of mother	0.7	0.9	3.0	-0.3	1.4	-0.1	-1.7	-0.1	1.0	-0.5	-1.4	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	6.9	-0.4	-2.6	-0.1	1.8	-1.9	1.3	-0.1	1.1	-0.6
Pulse wave Arterial Stiffness index	0.5	0.6	2.0	0.8	0.8	0.3	0.8	0.3	0.6	1.4	0.3	0.9
Impedance of arm (left)	0.7	3.5	10.1	-1.5	2.3	-2.0	-3.2	-0.1	-2.3	-1.8	-1.1	-0.2
Arm fat mass (right)	1.7	7.0	14.1	3.4	-0.9	3.3	3.8	0.9	2.9	3.4	0.6	1.9
Trunk predicted mass	0.9	5.2	13.0	1.4	-3.0	1.9	3.6	-1.7	3.0	2.1	1.7	0.1
Standing height	0.2	2.4	9.0	-0.8	-2.4	0.1	1.0	-3.0	1.3	-0.2	0.7	-1.5
Length of working week for main job	0.2	0.2	0.9	-0.1	0.5	0.1	-0.9	0.4	0.7	0.3	0.4	0.1
Exposure to tobacco smoke at home	3.2	3.6	12.0	-1.6	1.4	-1.7	-2.3	-0.6	-3.5	-2.6	-0.6	-0.4
Breastfed as a baby	0.5	0.6	2.6	-0.7	-0.5	-0.3	-0.1	-1.6	-0.1	-0.8	-0.9	-0.8
Tense / ‘highly strung’	0.9	1.4	3.3	-0.2	1.8	-0.9	-1.7	1.8	-0.2	0.9	-1.3	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	3.0	-0.1	-0.1	0.5	-0.6	0.0	-0.2	-1.0	-1.7	-1.1
Hair/balding pattern: Pattern 4	0.2	0.4	1.1	-0.8	-0.1	-0.5	-0.7	-0.3	0.4	-0.2	-0.9	-1.1
Birth weight of first child	2.1	3.8	11.0	1.0	-3.3	1.5	3.1	-1.1	2.5	1.2	1.4	0.1
Peak expiratory flow (PEF)	1.2	2.7	6.6	1.3	-0.9	1.1	2.3	-0.4	2.6	1.4	2.2	1.3
Pulse wave reflection index	0.8	1.0	3.6	0.8	1.9	-0.3	0.1	-0.0	-0.1	1.7	-0.1	1.1
Ever highly irritable/argumentative for 2 days	0.8	0.9	2.3	1.2	0.6	1.3	0.4	1.5	1.0	0.5	-0.7	0.5
Loud music exposure frequency	0.9	1.0	3.6	-0.3	1.9	-1.0	-1.3	1.1	0.3	0.4	0.7	0.6
Qualifications: O levels/GCSEs or equivalent	1.7	2.7	6.8	0.9	-2.3	1.3	2.6	0.3	2.2	0.6	2.1	0.1
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.8	-0.7	-0.5	-0.7	0.2	-0.8	-0.4	-0.9	0.5	-0.7
Blood clot in the leg (DVT)	0.7	0.9	2.9	-0.4	1.7	-0.7	-1.3	-0.2	-1.3	-1.2	0.1	-0.0
Medication: Paracetamol	0.6	1.0	3.1	-0.6	1.2	-1.0	-1.3	0.7	-1.8	-0.6	-1.0	-0.3
Headache pain in last month	0.4	0.7	1.9	1.4	0.1	1.3	0.9	0.1	0.3	0.8	-0.3	0.9
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.0	-0.9	-0.5	-0.3	-1.2	-0.8	1.4	-1.3	0.6	-0.6
Glaucoma (self-reported)	1.0	1.2	4.7	1.0	0.2	1.2	0.1	1.3	2.2	1.1	-0.3	0.6
Gout (self-reported)	0.2	0.3	1.4	0.0	0.2	-0.1	0.2	-1.2	-0.8	-0.6	-0.0	0.6
Hypothyroidism/myxoedema (self-reported)	1.4	2.7	6.3	2.5	-0.1	2.5	2.0	1.0	0.9	1.8	-1.0	1.3
Medication: Amlodipine	0.3	0.5	1.8	0.7	1.0	0.3	-0.3	1.4	0.2	0.4	0.1	0.8
Medication: Ventolin 100micrograms inhaler	0.5	0.7	2.6	0.9	1.1	0.5	-0.4	0.8	0.5	-0.2	0.2	1.6
Birth weight	0.7	1.4	5.1	-0.1	-2.2	-0.1	1.8	-0.3	1.1	0.4	1.5	-0.8
Chronic bronchitis/emphysema (mother)	1.3	1.5	5.0	-1.4	-0.6	-0.9	-0.5	-2.2	-1.0	-1.2	-0.8	-1.4
High blood pressure (siblings)	0.5	0.7	2.7	-1.0	0.6	-1.6	-0.7	-0.6	-0.8	0.6	-0.2	-0.9
Forced vital capacity (FVC), Best measure	0.5	1.9	5.6	-0.2	-2.4	0.1	2.0	-2.0	1.4	0.2	1.2	-0.1
Body fat percentage	1.1	4.5	9.3	3.0	0.2	2.8	2.6	1.4	1.5	2.9	-0.2	1.9
Leg fat percentage (right)	0.9	3.3	7.6	2.3	-0.3	2.2	2.6	1.0	1.6	2.8	-0.7	0.8
Arm fat-free mass (right)	0.7	3.5	9.4	1.6	-1.9	2.0	3.1	-0.9	2.5	1.8	1.4	0.5
Exposure to tobacco smoke outside home	0.7	1.0	3.5	-0.6	1.1	-0.7	-1.9	-0.4	-1.2	-1.1	-0.5	-0.3
Comparative body size at age 10	2.0	5.4	13.4	2.1	-2.2	1.9	3.7	0.5	3.0	2.6	1.9	1.9
Number of full brothers	0.2	0.2	1.0	-0.6	0.1	-1.0	-0.2	-0.4	0.4	0.1	0.4	0.0
Worry too long after embarrassment	0.9	1.5	3.2	1.8	-0.3	1.7	1.7	0.2	1.0	1.5	0.6	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	2.0	2.6	4.2	-2.0	0.3	-2.0	-1.9	-0.3	-1.7	-1.8	-1.3	-1.9
Wheeze or whistling in the chest in last year	1.1	1.9	7.2	-0.9	2.7	-1.5	-2.4	0.8	-0.1	0.6	-0.9	-0.1
Number of children fathered	0.4	0.4	1.2	0.1	0.3	0.4	-0.4	-0.8	-0.7	-0.9	-1.1	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	3.7	0.4	-1.9	0.9	1.1	-1.0	0.8	-0.4	0.3	-0.4
Age at first live birth	1.7	3.0	8.9	0.3	-2.9	0.4	3.0	0.6	2.1	0.6	1.9	-0.4
Pulse wave peak to peak time	0.6	0.7	2.3	-0.8	-1.0	-0.2	-0.7	-0.7	-0.6	-1.5	-0.4	-1.0
Health satisfaction	0.7	0.9	3.2	0.9	0.7	0.9	-0.1	0.2	1.8	1.0	0.9	0.9
Shortness of breath walking on level ground	0.7	0.8	3.5	0.3	1.9	0.2	-1.2	0.2	0.5	1.0	-0.0	0.9
Qualifications: College or University degree	1.2	3.7	11.7	1.6	-1.3	0.8	3.0	1.1	0.9	1.1	3.4	2.1
Eye problems/disorders: None of the above	0.5	0.6	1.7	-1.0	0.1	-0.7	-0.9	-0.4	-0.5	-0.8	-1.3	-0.6
Mouth/teeth dental problems: Loose teeth	0.5	0.5	2.0	0.1	1.2	0.3	-1.4	0.5	0.3	-0.6	-0.7	-0.1
Emphysema/chronic bronchitis	0.8	1.0	3.5	1.6	-0.0	1.9	0.6	0.4	0.7	0.5	0.7	0.9
Medication for pain relief, constipation, heartburn	0.2	0.4	0.9	0.3	-0.8	0.6	0.6	0.0	1.0	-0.2	0.9	0.5
Neck or shoulder pain in last month	4.2	5.9	10.5	-2.5	2.1	-2.8	-3.1	-1.3	-3.2	-3.1	-1.6	-0.7
Medication: Blood pressure	0.3	0.5	1.7	0.5	0.4	0.1	0.3	0.3	-1.0	0.9	-1.3	-0.3
Angina (self-reported)	1.5	2.0	5.0	-1.4	1.7	-1.9	-1.6	-0.2	-2.2	-0.8	-1.1	-0.2
Migraine (self-reported)	1.4	1.8	5.6	-1.1	0.1	-0.8	-1.4	-1.3	-1.1	-1.3	-2.4	-1.3
Medication: Ibuprofen	0.1	0.2	0.6	0.1	0.8	-0.0	-0.5	0.1	0.1	0.3	-0.6	-0.1
Medication: Allopurinol	0.4	0.5	1.6	0.1	0.0	-0.2	0.8	-0.2	-1.1	-0.4	0.7	1.3
Medication: Omeprazole	0.4	0.5	1.5	-0.4	0.6	-0.9	-0.3	1.2	0.1	0.1	-1.2	-0.3
Medication: Seretide 50 evohaler	0.5	0.6	1.8	-1.0	0.6	-0.8	-1.3	0.7	-0.7	0.1	-0.1	-0.5
Mean time to correctly identify matches	2.2	4.2	20.8	-0.4	-4.6	0.3	3.1	-1.6	0.7	-0.1	0.6	-2.0
Heart disease (mother)	0.7	0.9	2.2	-1.3	-0.7	-1.5	-0.1	-0.9	-1.3	-0.5	-0.1	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.9	-0.1	0.0	-0.4	-0.4	-0.2	0.1	-0.8	-1.0	-0.5
Whole body fat mass	1.3	5.4	11.9	3.1	-0.7	3.0	3.5	0.8	2.1	3.1	0.4	1.8
Leg fat mass (right)	1.2	4.7	9.9	2.9	-0.5	2.8	3.1	0.7	2.1	3.1	-0.1	1.3
Arm predicted mass (right)	0.8	4.2	10.7	1.6	-2.3	2.2	3.3	-1.2	2.7	1.8	1.5	0.4
Pulse rate, automated reading	0.2	0.8	2.9	-0.2	1.7	-0.6	-1.1	1.4	-0.3	-0.3	-0.0	0.3
Alcohol intake frequency.	0.5	1.3	3.5	1.5	0.9	1.4	0.1	1.9	-0.1	0.2	0.7	1.5
Comparative height size at age 10	0.3	1.7	6.1	-0.3	-2.5	0.3	1.6	-1.2	1.3	0.6	1.4	-0.9
Number of full sisters	0.6	0.8	2.1	-1.1	1.0	-0.8	-1.4	-0.6	-0.3	-1.0	-0.4	-0.8
Suffer from ‘nerves’	0.5	0.8	3.3	0.0	1.8	-0.5	-1.3	0.5	-1.1	0.0	-0.3	0.6
Overall health rating	0.6	1.3	4.7	-0.5	1.6	-0.1	-2.2	0.6	0.3	-1.0	-1.6	-0.6
Chest pain or discomfort	0.1	0.1	0.7	0.1	0.5	0.2	-0.4	0.1	0.2	0.9	0.0	0.2
Had major operations	0.8	1.0	3.2	-1.4	-1.0	-1.0	0.1	-1.0	-0.0	-0.7	-0.1	-1.8
Age at last live birth	0.9	1.4	5.5	-1.1	-2.3	-1.0	1.4	-0.3	0.4	-0.4	0.9	-1.2
Family relationship satisfaction	0.6	0.8	3.7	0.1	1.4	0.1	-1.9	0.7	0.2	-0.6	-0.4	0.6
Leg pain on walking	3.1	3.9	8.1	2.5	0.9	2.1	1.5	0.3	2.1	2.5	1.7	2.8
Qualifications: NVQ or HND or HNC or equivalent	2.3	2.7	7.0	-1.4	-0.1	-0.6	-2.0	-1.4	-1.8	-2.6	-2.2	-1.2
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.3	0.3	0.4	0.5	-0.7	1.1	0.5	0.1	-1.0	-0.1
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.9	0.3	-1.4	0.1	1.3	0.2	0.1	0.5	1.1	-0.1
Medication: Aspirin	0.4	0.5	1.4	0.8	0.9	-0.0	0.5	0.7	-0.3	1.2	0.5	0.8
Supplements: Vitamin C	0.4	0.5	2.1	-0.3	-0.3	-0.5	0.5	-1.5	-0.8	-0.5	0.7	0.0
Knee pain experienced in last month	0.7	1.0	2.9	1.0	0.1	1.4	1.0	0.1	1.7	1.2	-1.0	0.3
Hypertension (Self-reported)	0.2	0.5	0.8	-0.7	0.3	-0.9	-0.8	-0.4	-0.9	-0.5	-0.7	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	4.3	0.9	1.5	1.1	-1.0	0.6	0.4	0.8	-2.1	-0.1
Illnesses of father: Heart disease	2.0	2.7	5.4	2.0	-0.2	1.7	1.3	1.8	2.0	2.3	1.2	1.3
Illnesses of siblings: Diabetes	0.7	0.9	2.7	-0.8	-0.5	-0.7	-0.5	-0.9	-1.1	-0.5	-1.6	-1.2
Smoking status: Previous	0.3	0.4	1.4	0.6	0.5	0.3	0.5	-0.3	1.2	0.9	0.3	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	5.6	-0.5	-1.5	-0.0	0.8	-2.4	0.7	-0.9	0.3	-0.8
Whole body fat-free mass	1.0	5.7	14.1	2.0	-2.5	2.4	3.8	-1.2	3.2	2.3	1.9	0.7
Leg fat-free mass (right)	1.1	6.0	12.7	2.7	-1.6	2.9	3.6	-0.1	3.2	2.5	2.0	1.7
Arm fat percentage (left)	1.4	5.4	11.6	3.3	0.3	2.7	2.9	1.5	2.0	3.4	-0.1	2.2
Average weekly red wine intake	1.3	1.9	4.3	2.1	0.3	1.9	1.5	0.7	0.4	2.1	0.3	1.4
Handedness (chirality/laterality): Left-handed	1.0	1.2	3.8	-1.1	1.4	-1.3	-2.0	0.6	-0.6	-0.5	-0.9	-0.1
Mood swings	0.9	1.6	3.7	1.6	1.7	1.2	-0.1	1.9	1.1	0.9	0.1	1.4
Loneliness, isolation	0.5	0.8	1.9	1.2	0.8	1.4	-0.3	0.8	0.9	0.4	-0.0	1.0
Long-standing illness, disability or infirmity	1.3	2.1	8.0	-0.5	1.0	-0.1	-1.4	-1.6	-1.1	-1.6	-2.8	-1.0
Ever had bowel cancer screening	1.4	1.6	3.8	-1.6	-0.3	-1.6	-0.4	-1.1	-2.0	-1.5	-1.0	-1.1
Diabetes diagnosed by doctor	1.6	2.6	7.2	-1.8	-0.6	-0.9	-1.3	-1.6	-2.3	-2.7	-0.8	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	3.0	-1.7	-0.9	-1.7	-0.2	-1.5	-0.7	-0.7	0.2	-1.2
Friendships satisfaction	0.6	0.7	2.5	1.3	0.4	1.6	-0.3	0.8	0.6	0.2	0.3	0.7
Qualifications: nursing, teaching	0.3	0.5	1.2	1.0	-0.0	1.1	0.7	1.0	0.4	-0.6	0.3	0.8
Commuting to job workplace: Walk	1.0	1.1	3.6	-0.6	-1.3	-0.4	0.5	-1.2	1.9	0.2	1.2	-0.9
Eye problems/disorders: Cataract	0.2	0.2	0.9	0.7	0.5	0.6	-0.0	0.9	0.2	0.4	-0.2	0.1
Mouth/teeth dental problems: Mouth ulcers	1.3	2.0	4.7	-1.2	0.2	-0.6	-1.6	-1.3	-1.2	-2.2	-1.6	-1.8
Medication for cholesterol	0.9	1.3	4.5	-0.9	-2.1	-0.6	1.6	-0.7	0.5	0.9	1.3	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.9	2.3	5.6	-1.9	-0.9	-1.0	-1.3	-0.6	-0.8	-2.4	-1.2	-2.3
Back pain experienced in last month	3.1	4.5	15.2	-0.9	1.7	-0.6	-2.6	-1.9	-2.0	-2.1	-3.9	-1.5
Mineral and other dietary supplements	0.4	0.5	1.8	-0.3	0.8	-0.4	-1.1	1.3	-0.3	-0.1	-0.3	0.4
Breast cancer (self-reported)	0.3	0.4	1.1	0.2	-0.8	0.5	0.3	0.2	1.1	0.5	-0.1	-0.9
Asthma (self-reported)	0.4	0.8	2.9	0.7	1.7	0.0	-0.5	0.5	-0.1	0.7	0.5	1.5
Osteoporosis (self-reported)	0.5	0.6	1.7	-0.6	-0.9	-0.3	0.1	-0.8	-0.5	-1.3	0.3	-1.2
Osteoarthritis (self-reported)	0.2	0.3	0.8	0.5	-0.3	0.4	0.9	-0.3	0.1	0.8	-0.5	-0.2
Medication: Aspirin	0.3	0.4	1.2	0.6	1.1	-0.2	0.1	0.7	-0.3	0.9	0.3	0.6
Medication: Gliclazide	1.1	1.2	4.7	-0.9	-0.8	-0.0	-0.8	-1.2	-1.1	-2.2	-0.7	-1.0
Illnesses of father: None of the above (group 1)	0.3	0.3	1.0	-0.3	0.9	-0.2	-0.8	-0.0	-0.2	-0.0	-1.0	-0.4
Smoking status: Current	5.0	8.0	21.0	-2.2	3.0	-2.1	-4.6	-0.2	-3.8	-3.4	-2.4	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.5	1.2	0.0	0.8	0.9	0.4	0.9	0.7	0.5	1.1
Whole body water mass	1.0	5.9	14.4	2.0	-2.6	2.5	3.8	-1.2	3.3	2.3	1.9	0.7
Leg predicted mass (right)	1.1	6.1	12.7	2.7	-1.6	2.9	3.6	-0.1	3.2	2.5	2.1	1.8
Arm fat mass (left)	1.6	6.6	12.1	3.5	-0.5	3.2	3.5	0.8	2.7	3.5	0.5	2.1
Number of self-reported non-cancer illnesses	1.0	1.8	6.2	0.7	2.5	0.4	-1.5	0.0	-1.6	-0.6	-2.0	0.2
Average weekly champagne plus white wine intake	0.5	0.7	2.3	-1.2	0.0	-1.5	-1.1	0.2	-0.2	-0.6	1.1	-0.3
Miserableness	0.2	0.4	1.1	0.4	-0.6	0.4	1.0	0.2	1.1	1.0	-0.2	-0.1
Guilty feelings	0.9	1.4	2.7	1.4	0.5	0.6	1.4	-0.0	0.8	1.5	1.6	1.5
Wears glasses or contact lenses	0.5	0.6	3.6	-0.5	-0.4	-0.6	-0.1	-0.3	-1.9	-0.9	0.4	-0.3
Ever taken oral contraceptive pill	0.5	0.5	1.8	0.8	0.0	0.9	0.8	0.4	-0.1	0.8	0.0	1.3
Hearing aid user	1.3	1.4	5.2	0.5	2.3	0.2	-1.7	1.4	-0.1	0.5	-1.3	0.8
Mother’s age at death	0.5	0.6	1.6	-1.2	0.1	-1.1	-0.6	-0.1	-1.3	0.0	-0.0	-0.9
Financial situation satisfaction	0.6	0.8	3.3	0.6	0.8	0.9	-0.7	1.8	0.8	-0.0	-0.5	0.8
Tinnitus: Yes, now most or all of the time	2.3	2.7	12.8	0.8	0.7	0.0	0.9	0.2	1.9	1.5	3.6	1.9
Commuting to job workplace: Public transport	0.4	0.5	1.6	-0.0	1.3	-0.5	-0.6	0.5	-0.7	-0.3	1.1	0.8
Eye problems/disorders: Glaucoma	1.0	1.2	3.8	1.5	0.1	1.7	0.5	0.8	1.9	0.8	-0.0	0.7
Medication: Blood pressure	0.4	0.7	1.3	1.0	1.2	1.0	-0.8	0.9	0.8	-0.6	-0.5	0.7
Pain type(s) experienced in last month: Hip pain	4.1	5.1	11.6	-2.7	-0.4	-2.3	-1.4	-3.4	-1.4	-1.7	-2.6	-3.0
Supplements: Fish oil (including cod liver oil)	1.3	1.6	3.3	1.4	-0.7	1.4	1.8	-1.0	1.4	1.8	1.0	0.2
High cholesterol (Self-reported)	0.3	0.5	2.1	0.5	0.9	0.2	-0.0	-0.1	-1.4	-0.5	-0.7	0.4
Medication: Bendroflumethiazide	0.8	1.2	5.4	1.4	0.3	1.3	0.4	2.3	0.3	0.7	0.5	1.0
Medication: Paracetamol	1.2	1.9	5.8	-0.8	1.7	-1.5	-1.5	1.2	-2.4	-0.5	-1.1	-0.1
Medication: Lisinopril	0.6	0.8	3.7	1.1	0.2	1.3	0.3	0.3	-0.4	0.0	-1.9	-0.7
Medication: Atorvastatin	0.1	0.1	0.7	0.3	0.2	0.3	-0.1	0.8	-0.4	-0.4	-0.1	0.0
Illnesses of father: High blood pressure	1.1	1.3	4.5	-0.0	-1.7	-0.1	1.4	0.3	1.5	0.1	2.1	0.1
Alcohol drinker status: Never	2.1	2.5	6.5	1.7	1.2	0.9	0.6	2.2	0.1	1.0	2.2	2.5
Ever smoked	1.2	2.0	4.6	-1.6	1.9	-2.1	-2.1	-0.6	-1.2	-1.0	-0.3	-0.3
Basal metabolic rate	1.1	6.1	15.4	2.3	-2.4	2.7	3.9	-1.0	3.2	2.6	1.7	0.9
Leg fat percentage (left)	1.1	3.9	7.5	2.7	-0.2	2.6	2.7	1.1	1.8	2.7	-0.5	1.4
Arm fat-free mass (left)	1.0	5.3	12.8	1.7	-2.7	2.3	3.6	-1.5	3.0	2.0	1.9	0.5
Number of operations (self-reported)	0.2	0.3	0.8	-0.4	-0.7	-0.2	0.2	-0.5	0.2	-0.7	0.0	-0.9
Average weekly beer plus cider intake	0.9	1.3	4.4	-1.2	0.7	-1.1	-1.6	-0.1	-1.1	-2.1	-0.1	0.3
Irritability	0.2	0.4	2.2	-0.1	0.3	0.1	-0.0	0.0	-0.8	-0.3	-1.5	-0.6
Risk taking	0.6	0.9	2.3	-1.1	0.6	-0.9	-1.5	-0.7	-0.0	-1.3	-0.1	-0.8
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.8	-0.6	-0.7	-0.3	-0.1	-0.2	-1.0	-0.9	-1.3	-0.8
Fractured/broken bones in last 5 years	1.1	1.4	3.3	-1.1	1.6	-1.7	-1.8	0.5	-1.1	-1.2	0.1	-0.0
Age started oral contraceptive pill	0.3	0.4	1.6	0.3	-1.3	0.8	0.8	-0.6	-0.3	-0.4	-0.1	-0.5
Diastolic blood pressure, automated reading	1.0	3.0	7.8	2.1	0.7	1.5	1.7	1.2	1.2	1.4	2.0	2.8
Ever depressed for a whole week	0.5	0.6	2.2	0.4	1.0	0.8	-0.6	0.0	-1.1	0.2	-1.5	0.3
Unable to work because of sickness or disability	0.8	1.0	4.6	0.6	1.6	0.1	-0.8	2.1	0.2	0.3	-0.4	0.6
Commuting to job workplace: Cycle	1.4	1.7	5.6	-0.1	-2.4	0.2	2.0	-1.8	1.2	-0.3	1.0	-0.3
Myopia	0.8	1.1	3.3	-1.1	-0.8	-0.7	-0.5	-0.8	-1.2	-1.8	-1.0	-1.0
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.1	0.6	-0.4	0.9	0.6	0.5	0.9	0.3	1.0	0.9
Cholesterol lowering medication	0.4	0.6	1.5	0.4	1.2	0.3	-0.9	0.5	-0.4	-1.2	-1.0	0.1
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	3.0	-0.2	1.7	-1.1	-1.1	1.7	-0.3	-0.2	-1.4	0.1
Pain experienced in last month	2.5	4.1	14.9	0.7	-2.2	0.5	2.6	1.1	1.9	2.0	3.9	1.1
Supplements: Calcium	0.9	1.0	3.3	0.3	-1.8	0.4	1.6	0.1	0.8	0.5	1.2	-0.1
Basal cell carcinoma (self-reported)	1.5	1.8	4.6	-2.0	0.2	-2.1	-1.3	-0.5	-1.0	-0.9	-1.3	-1.3
Heart attack/myocardial infarction (self-reported)	0.9	1.2	4.5	-0.4	0.6	-0.3	-0.4	0.0	-2.1	0.1	-1.8	-1.5
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	3.2	-0.1	1.8	-0.5	-1.1	0.5	-1.0	-1.0	0.5	0.4
Heart disease (siblings)	0.8	0.9	2.5	-0.6	0.8	-1.0	-1.2	0.3	-1.6	-1.0	-1.2	0.1
Alcohol drinker status: Previous	0.9	1.1	2.3	-0.8	0.1	-0.6	-1.3	-1.0	-1.4	-1.2	-1.5	-0.7
Pack years of smoking	1.1	1.6	4.8	-0.4	2.1	-0.5	-2.2	0.2	-0.5	-0.7	-1.9	0.3
Impedance of whole body	1.4	6.9	18.1	-2.7	2.4	-3.0	-4.3	-0.5	-3.1	-2.7	-1.8	-1.2
Leg fat mass (left)	1.4	5.3	10.5	3.1	-0.6	3.1	3.2	0.8	2.4	3.0	0.1	1.6
Arm predicted mass (left)	1.0	5.3	13.5	1.7	-2.6	2.3	3.7	-1.3	3.0	2.2	1.8	0.5