Best TWAS P=1.59e-30 · Best GWAS P=1.8e-43 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | CYP1B1 | 0.16 | 0.06 | lasso | 5 | 0.07 | 3.8e-06 | -12.03 | -11.3 | 1.6e-29 | -0.26 | 0.63 | 0.04 | FALSE |
| 2 | GTEx | Artery Tibial | CYP1B1-AS1 | 0.14 | 0.02 | lasso | 3 | 0.03 | 9.3e-04 | -3.48 | -9.9 | 2.8e-23 | -0.24 | 0.41 | 0.03 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Female) | RMDN2 | 0.03 | 0.06 | lasso | 2 | 0.02 | 7.7e-02 | -5.87 | -7.2 | 6.6e-13 | -0.20 | 0.06 | 0.05 | TRUE |
| 4 | GTEx | Cells Transformed fibroblasts | RMDN2 | 0.12 | 0.04 | enet | 32 | 0.06 | 2.8e-05 | -9.33 | -6.2 | 6.8e-10 | -0.03 | 0.65 | 0.02 | FALSE |
| 5 | GTEx | Nerve Tibial | CYP1B1 | 0.20 | 0.09 | lasso | 4 | 0.10 | 2.2e-07 | 4.41 | -5.4 | 6.5e-08 | -0.20 | 0.96 | 0.00 | TRUE |
| 6 | GTEx | Nerve Tibial | CYP1B1-AS1 | 0.21 | 0.04 | enet | 37 | 0.06 | 2.4e-05 | 4.41 | -5.1 | 2.7e-07 | -0.33 | 0.47 | 0.03 | FALSE |
| 7 | GTEx | Skin Sun Exposed Lower leg | RMDN2 | 0.29 | 0.16 | enet | 41 | 0.18 | 5.4e-15 | -9.80 | -7.2 | 6.1e-13 | -0.12 | 1.00 | 0.00 | FALSE |
| 8 | GTEx | Skin Sun Exposed Lower leg | ATL2 | 0.11 | 0.00 | lasso | 9 | 0.00 | 8.9e-01 | -9.65 | -8.9 | 4.6e-19 | -0.09 | 0.15 | 0.08 | FALSE |
| 9 | GTEx | Testis | ATL2 | 0.32 | 0.15 | enet | 13 | 0.14 | 1.4e-06 | 2.58 | -5.2 | 2.2e-07 | -0.23 | 0.99 | 0.00 | FALSE |
| 10 | METSIM | Adipose | ATL2 | 0.05 | 0.01 | blup | 547 | 0.02 | 9.7e-04 | -0.46 | -5.5 | 4.3e-08 | -0.28 | 0.32 | 0.04 | TRUE |
| 11 | METSIM | Adipose | RMDN2 | 0.07 | 0.05 | lasso | 3 | 0.04 | 3.1e-06 | -9.51 | -9.8 | 1.2e-22 | -0.16 | 0.99 | 0.00 | TRUE |
| 12 | ROSMAP | Brain Pre-frontal Cortex | CYP1B1 | 0.08 | 0.00 | blup | 584 | 0.02 | 2.2e-03 | 6.25 | -7.5 | 5.4e-14 | -0.39 | 0.08 | 0.36 | FALSE |
| 13 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ATL2 | 0.03 | 0.02 | blup | 66 | 0.01 | 3.4e-03 | -3.59 | -5.4 | 7.9e-08 | -0.32 | 0.04 | 0.06 | FALSE |
| 14 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FAM82A1 | 0.13 | 0.09 | lasso | 7 | 0.10 | 2.6e-20 | -9.65 | -8.7 | 3.3e-18 | -0.12 | 1.00 | 0.00 | TRUE |
| 15 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | FAM82A1 | 0.05 | 0.03 | lasso | 4 | 0.04 | 2.2e-05 | -9.80 | -11.5 | 1.6e-30 | -0.19 | 0.34 | 0.02 | TRUE |
| 16 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C2orf58 | 0.11 | 0.00 | enet | 12 | 0.04 | 1.7e-03 | -12.86 | 7.6 | 2.7e-14 | 0.19 | 0.00 | 0.86 | FALSE |
| 17 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | FAM82A1 | 0.06 | 0.02 | blup | 135 | 0.04 | 1.0e-03 | -9.04 | -10.7 | 1.5e-26 | -0.24 | 0.27 | 0.06 | FALSE |
| 18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C2orf58 | 0.08 | 0.00 | enet | 14 | 0.04 | 7.8e-05 | -4.96 | 5.6 | 2.8e-08 | 0.05 | 0.19 | 0.34 | FALSE |
| 19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FAM82A1 | 0.12 | 0.07 | blup | 136 | 0.11 | 3.4e-11 | -9.65 | -6.7 | 1.9e-11 | -0.05 | 1.00 | 0.00 | FALSE |
| 20 | The Cancer Genome Atlas | Stomach Adenocarcinoma | FAM82A1 | 0.05 | 0.03 | blup | 135 | 0.03 | 3.0e-03 | 9.64 | -10.6 | 2.9e-26 | -0.39 | 0.07 | 0.06 | TRUE |
| 21 | The Cancer Genome Atlas | Thyroid Carcinoma | FAM82A1 | 0.06 | 0.02 | blup | 135 | 0.02 | 4.9e-03 | -9.33 | -5.8 | 6.7e-09 | 0.03 | 0.28 | 0.04 | FALSE |
| 22 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | FAM82A1 | 0.50 | 0.06 | lasso | 4 | 0.13 | 1.5e-04 | -8.85 | -5.3 | 8.9e-08 | -0.05 | 0.06 | 0.05 | TRUE |