Hub : Genes

CYP1B1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1578	0.0449	5.9e-05	0.058	NA	0.066	NA	0.070	2.5e-05	NA	6.5e-06	NA	3.8e-06
2	GTEx	Muscle Skeletal	0.0592	0.0256	7.5e-03	0.002	NA	-0.003	NA	0.001	2.1e-01	NA	9.2e-01	NA	2.4e-01
3	GTEx	Nerve Tibial	0.2037	0.0608	8.6e-05	0.093	NA	0.073	NA	0.097	3.9e-07	NA	7.0e-06	NA	2.2e-07
4	NTR	Blood	0.0873	0.0202	1.6e-09	0.024	0.033	0.056	0.062	0.063	1.7e-08	7.8e-11	1.2e-17	2.4e-19	1.3e-19
5	ROSMAP	Brain Pre-frontal Cortex	0.0775	0.0287	1.9e-03	0.001	0.017	0.002	0.017	0.002	2.4e-01	2.2e-03	1.7e-01	2.4e-03	1.8e-01
6	YFS	Blood	0.2445	0.0333	0.0e+00	0.081	0.145	0.145	0.138	0.139	3.6e-25	3.9e-45	6.0e-45	7.3e-43	2.8e-43
7	TCGA	Thyroid Carcinoma	0.0420	0.0220	1.4e-03	0.009	0.023	0.009	NA	0.012	4.0e-02	2.4e-03	3.8e-02	NA	2.0e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.6	1.0	2.6	1.1	0.9	0.9	-0.6	1.6	-1.0	-0.4
Bipolar Disorder or Schizophrenia	0.6	1.5	5.1	-0.9	1.0	0.1	-1.3	1.2	-2.3	0.4
Depressed Affect (Nagel 2018)	0.4	0.9	2.3	0.5	-1.5	-1.3	-0.1	0.2	0.6	1.3
Depression (Nagel 2018)	0.6	0.8	2.3	0.8	-1.3	-1.5	-0.3	-0.6	0.0	0.9
Intelligence (Savage-Jansen 2018)	0.6	2.0	4.3	-1.0	-1.2	-2.1	1.5	-0.8	1.9	0.9
Neuroticism (Nagel 2018)	0.2	0.4	1.2	1.1	-0.7	-0.1	-0.0	1.1	0.3	0.3
Schizophrenia (2018)	0.7	1.5	4.0	-2.0	0.5	-0.5	-1.2	0.2	-2.0	0.8
Schizophrenia vs Biploar Disorder	2.0	2.6	8.1	-1.6	-1.3	-1.9	-0.9	-2.8	-0.3	1.1
Worry (Nagel 2018)	0.2	0.4	1.3	0.1	0.4	1.2	0.1	0.6	0.0	-1.0
Alzheimer’s Disease (in mother)	0.5	0.6	1.5	1.2	-0.3	0.1	-1.1	1.2	0.1	-0.2
Alzheimer’s Disease (in father)	1.6	1.7	4.8	0.5	-0.5	-1.0	2.2	-0.4	2.2	0.7
Alzheimer’s Disease (including proxy)	0.5	0.7	1.8	1.1	-0.0	-0.6	1.0	0.5	1.3	0.1
Crohns Disease (2017)	0.1	0.2	0.4	-0.4	0.0	0.4	0.6	-0.4	0.5	0.0
Irritable Bowel Disease (IBD)	0.2	0.5	1.7	-0.5	1.2	1.3	-0.1	0.0	-0.4	-0.5
Ulcerative Colitis (UC)	0.4	0.8	1.8	-0.4	0.9	1.3	-1.1	0.4	-1.2	-0.3
Major Depression (MDD)	1.2	1.5	3.9	1.6	0.9	2.0	0.3	1.2	0.2	-1.2
Reaction Time	0.4	0.7	2.3	1.5	0.5	0.7	0.2	0.5	-0.9	0.8
Verbal and Numeric Reasoning (VNR)	1.5	3.6	11.8	-0.4	-0.0	-2.1	2.8	-0.9	3.4	0.6
Breast Cancer	0.3	0.7	1.3	-0.6	1.1	0.5	1.1	0.6	0.5	-0.9
Ovarian Cancer	0.4	0.5	1.5	0.6	-0.0	0.6	-0.6	0.8	-1.2	0.1
Prostate Cancer	0.3	0.4	1.0	-0.1	-1.0	0.7	-0.2	1.0	0.0	0.1
Age at First Birth	0.9	1.4	5.7	2.4	0.8	1.3	0.2	1.0	-0.7	-0.4
Bipolar Disorder (2011)	0.5	0.5	1.2	0.3	-0.2	-1.0	-1.0	0.1	-1.1	0.3
Body Mass Index (BMI) (2010)	0.3	0.4	1.1	1.1	0.0	-0.3	0.3	-0.8	0.7	-0.4
Coronary Artery Disease (CAD)	1.1	1.4	3.2	0.9	0.3	1.6	-0.8	1.8	1.1	-1.2
Crohns Disease (2012)	0.2	0.3	0.7	0.1	0.7	0.1	0.7	0.5	0.4	-0.9
Mean Putamen Volume	1.3	1.5	4.6	2.1	-0.9	0.6	-1.6	0.3	-1.2	-0.7
Fasting Glucose	1.5	1.8	6.4	0.3	2.5	0.2	1.8	0.2	1.5	-0.7
HbA1C	0.7	0.7	2.6	-1.6	0.3	0.1	0.3	-0.7	1.3	-0.4
HDL Cholesterol	0.2	0.3	1.2	0.5	-0.4	1.1	0.2	-0.1	0.4	0.6
LDL Cholesterol	0.2	0.4	1.8	0.2	-0.3	-0.1	-0.8	-0.1	-1.4	0.0
Lupus	0.4	0.6	2.0	-0.6	0.4	1.1	-0.1	-0.6	0.3	-1.4
Neuroticism (2016)	0.5	0.7	2.4	0.6	-0.4	-0.3	0.6	-0.1	1.5	-1.2
Primary Biliary Cirrhosis	0.8	1.1	3.4	0.5	0.1	1.8	-1.3	-0.9	-0.4	-1.1
Rheumatoid Arthritis	0.6	0.8	4.2	0.4	-0.5	-0.1	0.2	2.0	0.0	-0.9
Schizophrenia (2014)	0.8	1.8	4.2	-2.1	0.1	-0.5	-1.7	0.4	-2.0	0.9
Triglycerides	0.2	0.3	0.9	0.4	0.4	-0.2	1.0	0.2	0.5	-0.6
Type 2 Diabetes (T2D) (2012)	0.5	0.6	2.3	0.4	-0.1	1.2	-0.3	0.0	-0.0	-1.5
Ulcerative Colitis	0.6	0.8	2.8	-0.7	1.7	0.9	-0.3	0.8	-0.7	-0.7
Blood Eosinophil Count	0.9	6.6	23.8	-4.9	0.1	-3.4	0.1	-2.5	1.9	-0.8
Blood Platelet Count	0.2	2.4	10.6	0.3	1.8	1.1	0.9	3.2	0.6	-0.9
Blood Red Count	0.1	0.7	2.4	1.1	0.9	0.3	0.3	0.1	1.6	-0.1
Blood White Count	0.3	2.3	4.0	-2.0	-1.2	-1.8	-1.7	-1.8	-0.1	0.9
Heel T-Score	0.0	0.4	1.3	0.2	0.3	1.0	0.3	1.1	-0.4	-0.2
BMI	0.8	4.7	8.6	-0.4	-2.2	-2.9	-2.5	-2.7	0.2	2.3
Height	0.8	16.2	71.2	6.2	0.4	1.7	0.4	8.4	-0.1	0.2
Waist Hip Ratio (WHR)	0.3	1.4	8.5	0.1	0.8	0.5	0.3	2.9	0.1	0.6
Systolic Blood Pressure	0.2	1.0	2.3	-0.4	1.5	0.4	1.2	1.0	1.2	0.6
Smoking Status	0.6	1.5	4.3	1.5	-1.2	-0.7	-0.7	-1.1	0.0	2.1
Allergy or Eczema	0.4	1.1	3.0	0.7	0.8	0.7	-1.5	-0.1	-1.7	-1.1
Cardiovascular Disease	0.8	2.8	5.2	2.3	-1.1	-0.3	-2.3	1.7	-0.7	2.1
Hypothyroidism (self reported)	0.3	0.6	1.3	-0.7	-0.5	-0.8	0.3	-0.6	1.1	-1.2
Respiratory disease	1.7	3.9	9.5	-2.9	-0.1	-2.8	-0.0	-3.1	1.1	-0.8
Type 2 Diabetes (T2D) (2018)	1.0	1.8	5.8	2.4	-1.9	-0.9	0.0	-0.1	0.9	1.4
Lung FEV1/FVC ratio	0.5	2.5	8.8	3.0	-1.0	1.6	0.0	1.3	1.5	1.1
Lung FVC	0.2	1.1	2.7	-1.6	-1.1	-1.3	-0.5	-1.2	-0.4	0.8
Neuroticism	0.2	0.5	2.5	1.0	-0.1	0.1	0.1	1.6	0.4	-0.0
Chronotype (morning person)	0.6	1.3	3.6	0.4	1.0	0.5	1.9	-0.5	1.2	-1.5
Hair Pigment	0.1	1.9	4.0	1.8	0.9	-0.6	1.3	-1.7	-0.0	-2.0
Tanning	2.6	32.0	127.7	-11.3	-0.0	-5.4	0.8	-7.5	3.1	-0.5
Hand grip strength (left)	0.3	0.7	3.8	-0.6	-0.1	-2.0	-0.6	-0.0	0.1	0.3
Number of treatments/medications taken	0.5	1.0	3.3	-0.0	-1.8	0.3	-1.1	0.6	0.4	1.3
Average weekly spirits intake	1.5	1.9	3.9	0.4	-2.0	-0.7	-1.8	-1.1	-1.8	0.8
Sensitivity / hurt feelings	0.5	0.8	1.2	0.5	-1.1	-1.1	-0.9	0.5	-1.0	0.9
Frequency of depressed mood in last 2 weeks	0.7	1.0	3.7	0.4	-0.9	-1.9	-0.4	-0.5	-0.5	1.2
Hearing difficulty/problems: Yes	0.2	0.2	0.6	-0.8	-0.3	-0.6	0.2	-0.7	0.3	-0.3
Relative age of first facial hair	0.9	1.8	5.7	-0.7	-1.4	-2.4	-0.2	-1.7	0.8	0.8
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	5.4	0.9	-1.2	0.9	-2.3	0.5	-1.8	-0.4
Ever used hormone-replacement therapy (HRT)	1.1	1.4	4.2	2.0	0.6	0.0	-1.1	-0.7	-0.5	-1.9
Ever had hysterectomy (womb removed)	0.6	0.6	1.6	0.6	0.6	0.9	0.7	-0.2	0.9	-1.2
Systolic blood pressure, automated reading	0.3	0.8	3.1	-1.8	0.6	-0.7	0.2	0.2	0.4	1.1
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	1.6	0.7	-0.3	-0.3	-0.6	1.3	-1.1	0.6
Angina	1.0	1.3	3.4	-0.6	-1.9	-1.8	-0.7	-1.1	0.4	0.2
Medication for hormone replacement therapy	0.5	0.6	2.0	0.4	0.9	-0.5	0.5	-0.7	0.0	-1.4
Vitamin and mineral supplements	0.9	1.2	1.7	-1.0	-1.0	-0.9	-1.2	1.2	-1.0	1.3
Supplements: Zinc	1.5	1.6	3.1	-1.8	-1.6	-1.2	-0.2	-1.6	0.7	1.1
Medication: Co-codamol	0.4	0.4	1.4	-1.2	-0.0	-0.7	-0.6	0.6	-0.6	0.3
Medication: Metformin	0.4	0.6	2.3	0.5	-1.5	0.4	-0.3	0.6	-0.4	0.9
Diabetes (father)	1.1	1.4	7.7	2.8	0.5	1.0	-0.5	0.0	-0.3	-0.6
Diabetes (mother)	0.3	0.4	1.5	-0.4	0.2	0.1	0.3	-0.6	0.9	1.2
Severe depression (siblings)	1.1	1.2	3.5	-0.7	-0.8	-1.9	-1.1	0.4	-1.2	1.0
Pack years adult smoking proportion	0.2	0.2	1.5	-0.3	-0.0	-0.3	0.0	-0.2	-0.1	1.2
Impedance of leg (right)	0.2	1.0	2.6	-0.3	1.4	-0.3	1.6	-0.0	1.0	-1.2
Leg fat-free mass (left)	0.6	3.0	6.6	2.6	-1.8	-0.7	-1.9	1.5	-1.1	1.8
Trunk fat percentage	0.4	1.7	5.4	1.1	-1.6	-0.9	-2.3	-0.2	-1.0	1.0
Hand grip strength (right)	0.1	0.2	0.7	0.0	0.2	-0.7	-0.6	0.8	-0.2	0.0
Townsend deprivation index at recruitment	0.3	0.4	2.0	0.0	0.3	1.4	-0.5	0.4	-0.4	-0.2
Current tobacco smoking	1.5	2.4	8.3	1.0	-1.6	-1.7	-1.4	-0.5	-0.2	2.9
Average weekly fortified wine intake	1.3	1.5	5.5	-0.2	2.3	-0.8	1.1	-1.2	0.2	-1.2
Maternal smoking around birth	1.5	2.1	6.5	-0.7	-2.6	-1.1	-1.2	1.1	-1.5	1.2
Fed-up feelings	1.6	2.9	6.0	0.2	-2.5	-1.6	1.8	0.9	1.2	2.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.1	4.3	-0.8	-1.4	-2.1	0.4	-0.5	0.0	0.8
Relative age voice broke	0.4	0.6	1.9	0.2	1.4	0.5	0.8	0.1	-0.6	-1.0
Taking other prescription medications	0.9	1.3	6.7	-0.9	-2.6	-0.7	-0.4	-0.6	0.7	0.6
Age when periods started (menarche)	0.2	0.4	1.4	-0.8	0.1	0.2	-0.8	-0.1	-0.4	-1.2
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.8	0.9	-0.4	-0.2	-0.3	-0.5	0.7	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.1	-0.7	0.2	-0.6	0.6	-0.3	0.5	1.1
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	3.7	-1.9	-0.4	-0.7	0.6	-1.1	0.9	-0.2
Qualifications: CSEs or equivalent	0.9	1.2	3.5	-0.8	-0.3	-1.2	0.1	-1.9	1.2	0.9
Serious illness, injury or assault to yourself	1.2	1.5	6.1	-1.0	-0.0	-0.4	1.6	-0.5	2.5	0.5
High blood pressure	1.0	2.8	7.3	1.1	-1.7	0.9	-1.7	2.7	-0.6	2.1
Hayfever, allergic rhinitis or eczema	0.3	0.6	0.8	0.6	0.4	0.9	-0.8	0.4	-0.9	-0.9
Multivitamins +/- minerals	1.0	1.3	3.1	-0.1	1.4	0.8	1.1	-1.2	0.8	-1.8
Stomach or abdominal pain in last month	1.2	1.5	4.7	0.2	0.3	-1.4	2.2	-0.9	1.3	-1.0
Supplements: Glucosamine	0.4	0.5	1.7	-0.0	0.2	-0.7	-0.4	-0.9	0.6	-1.3
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	2.1	0.3	0.9	1.0	0.5	-1.4	0.7	-1.4
Medication: Atenolol	0.6	0.8	1.8	-0.2	-0.9	0.8	-0.2	1.1	-1.4	1.0
Medication: Levothyroxine sodium	0.3	0.5	1.2	-0.2	-0.5	-1.0	-0.4	-0.8	0.2	-1.1
Sitting height	0.6	4.2	19.0	4.4	1.5	0.2	0.3	2.7	-0.7	-0.6
Chronic bronchitis/emphysema (father)	1.1	1.3	5.4	-2.3	0.5	-1.3	-0.5	-1.1	0.1	-0.4
High blood pressure (mother)	0.6	0.8	3.2	-0.6	-0.5	-0.1	1.2	-0.1	1.8	0.4
Body mass index (BMI)	1.1	4.7	8.4	-0.6	-2.9	-2.4	-2.8	-1.9	-1.0	2.4
Impedance of leg (left)	0.2	1.0	2.8	-0.1	1.7	0.4	1.2	0.3	0.9	-1.2
Leg predicted mass (left)	0.5	2.9	6.8	2.6	-1.8	-0.7	-1.8	1.6	-1.0	1.8
Trunk fat mass	0.5	2.1	5.8	1.6	-1.6	-1.1	-2.4	0.1	-1.0	1.3
Waist circumference	1.0	3.8	8.8	0.6	-2.6	-1.7	-3.0	0.0	-1.3	2.5
Number of incorrect matches in round	1.0	1.7	3.2	1.4	1.8	1.6	0.7	0.8	-0.2	-1.7
Past tobacco smoking	0.5	0.9	2.8	-1.2	0.2	0.7	0.8	1.7	0.8	-0.3
Alcohol usually taken with meals	3.2	5.2	12.1	0.3	1.9	2.9	2.2	1.6	2.1	-3.5
Nervous feelings	0.6	1.2	5.9	-0.2	-0.1	-0.1	2.4	-0.2	1.4	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.6	-0.9	-0.8	-0.5	1.2	1.2	-0.0	0.3
Hearing difficulty/problems with background noise	1.2	1.9	7.4	-0.9	0.5	-0.2	1.6	-0.8	2.7	-1.2
Hair/balding pattern: Pattern 2	0.4	0.5	1.3	0.7	-1.1	-0.2	-0.8	1.0	0.1	0.4
Had menopause	1.8	2.3	7.0	-0.9	1.7	-0.0	1.6	-1.5	0.8	-2.6
Had other major operations	1.0	1.2	2.8	-1.4	-0.2	0.6	0.6	-1.7	0.3	-1.6
Forced vital capacity (FVC)	0.2	0.6	3.0	1.7	0.4	0.3	0.6	0.8	0.2	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.9	0.1	-0.2	0.0	-0.1	0.6	-0.9	0.7
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	4.3	0.4	-0.7	0.9	-0.9	1.2	-2.1	0.3
Qualifications: None of the above	0.3	0.5	2.3	0.6	0.1	-1.5	0.1	-1.0	-0.3	-0.2
Financial difficulties in last 2 years	0.2	0.3	0.7	0.2	-0.9	-0.2	0.7	0.6	-0.1	0.7
Mouth/teeth dental problems	0.6	0.9	3.8	-1.1	-0.4	-0.6	0.4	-0.7	0.6	1.9
Heart attack	0.2	0.2	0.4	-0.5	0.1	-0.7	-0.2	0.3	-0.5	0.6
Allergy	0.1	0.3	0.6	0.4	0.2	0.6	0.4	0.7	0.6	0.8
Pain all over the body in last month	0.2	0.2	0.8	0.0	0.3	0.9	0.2	-0.3	0.6	-0.3
Diabetes (self-reported)	0.3	0.5	1.1	0.8	-0.9	-0.3	0.5	0.4	1.0	0.3
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	6.2	-2.5	-1.3	-0.9	1.2	-1.5	1.4	0.7
Medication: Ramipril	1.1	1.5	5.8	1.1	-0.4	0.6	-2.4	1.1	-1.2	0.2
Medication: Simvastatin	0.5	0.8	3.0	0.1	-0.3	0.6	-0.8	1.0	0.5	1.7
Fluid intelligence score	1.3	2.7	9.0	-0.3	0.6	-0.9	3.0	-0.9	2.7	-1.0
Illnesses of siblings	0.3	0.4	1.2	-0.1	-0.8	0.3	0.6	-0.5	1.1	0.7
Neuroticism score	0.3	0.6	1.5	1.1	-0.8	-0.3	0.5	1.2	0.7	0.3
Weight	0.6	3.2	6.9	1.9	-2.1	-1.5	-2.6	0.5	-1.1	2.0
Impedance of arm (right)	1.0	4.6	7.6	2.1	2.8	2.3	1.9	2.1	0.5	-2.6
Arm fat percentage (right)	0.6	2.3	5.1	0.2	-2.1	-1.2	-2.2	-1.1	-0.8	1.7
Trunk fat-free mass	0.4	2.2	4.3	2.1	-1.5	-1.4	-1.1	1.4	0.1	1.9
Hip circumference	0.8	3.3	8.9	1.6	-2.2	-1.6	-3.0	-0.7	-1.1	1.5
Time employed in main current job	0.4	0.5	1.6	0.6	-0.3	0.2	-0.9	1.3	-0.5	-0.3
Alcohol intake versus 10 years previously	0.8	1.2	6.7	2.6	-0.7	-0.2	0.8	0.1	0.7	-0.4
Father’s age at death	0.5	0.7	2.7	-0.1	0.1	-0.2	1.5	-0.1	1.7	-0.3
Worrier / anxious feelings	0.1	0.1	0.4	0.1	-0.0	0.5	0.1	-0.1	0.0	-0.6
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	3.5	0.9	-1.9	-0.3	-0.5	1.8	-0.6	1.6
Falls in the last year	0.6	0.8	3.9	-0.3	-0.6	0.8	-0.3	2.0	-0.1	0.7
Hair/balding pattern: Pattern 3	0.4	0.6	2.7	0.1	0.5	1.6	0.6	0.5	-0.5	-0.2
Number of live births	0.2	0.3	0.8	-0.9	0.6	-0.7	0.4	0.1	-0.1	-0.2
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	6.4	2.5	-0.0	1.1	-0.2	1.5	-0.2	0.3
Pulse rate	1.0	1.6	4.5	-2.1	-0.7	-1.3	-0.9	-0.7	1.0	1.5
Happiness	1.0	1.2	3.5	1.0	1.3	1.2	-0.3	1.9	-0.8	-0.2
Noisy workplace	1.8	2.2	4.7	2.2	-1.0	-0.4	-1.8	1.3	-2.1	0.4
Qualifications: A levels/AS levels or equivalent	0.3	0.7	3.0	-0.8	0.2	-0.3	0.5	-1.7	1.0	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.8	0.4	-0.9	0.2	-0.3	-0.4	0.0	-0.2
Mouth/teeth dental problems: Dentures	1.8	3.1	11.4	-0.0	2.4	0.4	0.8	-1.1	1.4	-3.4
Asthma	1.4	2.8	8.8	-3.0	-0.8	-2.4	0.4	-1.9	0.6	0.1
Medication: Ibuprofen (e.g. Nurofen)	2.9	3.7	7.5	1.1	-1.6	1.1	-2.7	2.3	-2.7	1.1
Medication: Cholesterol lowering	2.3	3.5	6.0	1.6	-1.4	2.4	-2.5	1.9	-1.4	1.7
Depression (self-reported)	0.2	0.3	0.7	-0.3	-0.1	-0.1	0.9	-0.7	0.1	-0.8
Medication: Lansoprazole	0.4	0.5	2.5	-0.3	0.3	-1.6	0.5	-0.1	0.0	-0.7
Prospective memory result	0.8	1.0	1.9	-0.5	1.0	1.3	-1.4	-0.1	-1.3	-0.5
Lung cancer (father)	1.4	1.7	5.2	0.1	-0.2	-0.5	-2.3	0.7	-2.1	1.2
Illnesses of mother	0.1	0.2	0.9	-0.2	0.2	-0.1	0.4	-0.9	0.2	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	4.8	2.2	-0.8	1.3	-0.8	2.0	-0.5	0.5
Pulse wave Arterial Stiffness index	2.3	2.7	5.1	1.5	1.3	1.4	-2.0	2.3	-2.0	-0.1
Impedance of arm (left)	0.8	3.6	5.7	1.6	2.2	2.4	1.0	2.3	-0.0	-2.4
Arm fat mass (right)	0.7	3.1	6.5	1.0	-2.5	-1.6	-2.5	-0.4	-1.0	2.0
Trunk predicted mass	0.3	2.0	4.4	2.1	-1.4	-1.3	-1.0	1.3	0.2	1.8
Standing height	0.9	8.9	29.4	5.3	1.3	1.7	0.5	5.4	-0.0	-0.3
Length of working week for main job	0.8	0.9	2.4	-1.6	1.3	0.9	-0.5	0.0	-0.6	-0.8
Exposure to tobacco smoke at home	0.5	0.5	1.0	-0.5	-1.0	-0.6	-0.2	-0.8	0.9	0.8
Breastfed as a baby	0.6	0.8	1.7	-0.7	1.1	0.8	0.8	0.6	0.7	1.3
Tense / ‘highly strung’	1.3	2.1	6.6	1.5	1.3	1.4	-0.3	2.6	-0.8	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.9	-0.2	-1.4	-0.8	-0.5	-0.7	0.3	0.6
Hair/balding pattern: Pattern 4	0.1	0.2	0.9	0.2	-0.9	0.1	-0.1	-0.2	-0.3	0.2
Birth weight of first child	1.0	1.8	7.0	0.4	0.6	-1.0	2.6	-1.3	1.5	-0.4
Peak expiratory flow (PEF)	1.0	2.2	9.4	3.1	-1.2	0.7	-0.2	1.4	0.3	1.5
Pulse wave reflection index	1.0	1.3	2.5	1.4	1.4	1.6	-0.9	1.3	-0.6	-0.3
Ever highly irritable/argumentative for 2 days	1.6	2.0	4.1	-0.2	-1.0	-0.9	-2.0	0.8	-2.0	1.7
Loud music exposure frequency	0.3	0.3	0.5	0.2	0.6	0.5	0.7	-0.5	0.6	-0.5
Qualifications: O levels/GCSEs or equivalent	0.5	0.9	3.0	-0.7	-0.2	-0.5	0.2	-1.7	0.5	-1.4
Mouth/teeth dental problems: Bleeding gums	2.1	2.8	6.7	0.5	-0.8	1.4	-2.6	1.6	-2.5	-1.0
Blood clot in the leg (DVT)	0.2	0.3	0.7	0.4	-0.2	-0.2	0.4	-0.8	-0.4	-0.8
Medication: Paracetamol	0.2	0.3	1.0	0.5	-1.0	0.5	-0.6	0.1	-0.3	0.2
Headache pain in last month	0.4	0.7	3.1	-1.0	-0.3	-1.8	-0.5	0.4	0.3	0.1
Medication for cholesterol, blood pressure or diabetes	1.8	3.0	5.0	-2.0	2.0	-1.4	2.2	-1.1	0.9	-2.0
Glaucoma (self-reported)	1.1	1.3	2.9	1.7	-0.7	1.0	-1.4	1.2	-1.1	-0.4
Gout (self-reported)	0.4	0.6	2.9	-0.4	-0.5	-0.1	-0.6	-0.8	0.1	1.7
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	2.5	-1.1	-1.1	-1.6	0.0	-0.6	0.7	-0.9
Medication: Amlodipine	1.6	2.2	10.3	0.3	-1.6	0.3	-0.7	1.2	-0.4	3.2
Medication: Ventolin 100micrograms inhaler	3.0	3.9	9.1	-2.9	-1.8	-3.0	-0.5	-1.2	1.5	1.5
Birth weight	0.5	1.2	2.7	0.7	-1.3	-1.5	0.1	1.1	-0.3	1.6
Chronic bronchitis/emphysema (mother)	1.4	1.6	4.5	-1.8	0.3	-2.1	-0.1	-1.6	0.0	-1.1
High blood pressure (siblings)	0.7	1.0	3.5	-0.5	0.4	0.5	-0.9	1.9	-1.1	0.8
Forced vital capacity (FVC), Best measure	0.2	0.9	2.2	1.5	-1.1	0.1	-0.3	1.2	-0.2	1.1
Body fat percentage	0.6	2.2	5.7	0.3	-1.9	-1.4	-2.4	-1.2	-1.0	1.3
Leg fat percentage (right)	1.2	4.2	8.8	-1.3	-2.0	-2.9	-2.0	-3.0	-0.6	1.4
Arm fat-free mass (right)	0.5	2.5	3.8	1.9	-1.9	-1.0	-1.9	1.2	-1.0	1.8
Exposure to tobacco smoke outside home	1.0	1.3	3.1	-1.6	-0.5	-1.6	-0.9	-1.8	-0.2	-0.5
Comparative body size at age 10	1.2	3.3	10.3	-2.4	-0.5	-1.3	-0.5	-3.2	1.1	1.9
Number of full brothers	0.8	1.0	3.2	-0.2	0.2	0.6	-0.7	1.8	-1.6	-0.1
Worry too long after embarrassment	0.6	1.1	2.4	1.5	-0.9	0.2	-0.0	1.2	1.4	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.6	-0.9	-1.3	-1.2	-0.6	-0.5	-0.5	0.9
Wheeze or whistling in the chest in last year	1.4	2.6	6.5	-2.4	-0.3	-2.5	0.9	-2.0	0.9	0.3
Number of children fathered	0.7	0.8	2.4	-0.3	-1.6	-1.0	-0.6	0.9	-0.0	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.6	1.6	0.4	0.7	0.8	-0.6	-0.1	-1.3	-1.2
Age at first live birth	2.2	4.0	9.7	3.1	2.4	0.9	2.7	0.0	1.7	-1.3
Pulse wave peak to peak time	2.2	2.6	4.9	-1.3	-1.2	-1.3	2.2	-1.9	2.2	0.1
Health satisfaction	0.5	0.7	2.9	-0.7	0.6	0.3	-0.4	0.8	-1.7	0.3
Shortness of breath walking on level ground	1.3	1.6	3.3	0.5	-1.2	-1.4	-1.7	0.6	-0.9	1.8
Qualifications: College or University degree	0.1	0.4	1.3	-0.1	0.8	1.1	0.7	0.5	-0.4	-0.6
Eye problems/disorders: None of the above	1.7	1.9	4.7	-2.1	0.0	-1.6	0.5	-2.2	1.2	0.2
Mouth/teeth dental problems: Loose teeth	1.1	1.3	3.1	-1.8	1.5	0.6	-0.5	-0.8	-0.3	-1.6
Emphysema/chronic bronchitis	1.3	1.5	3.0	-1.1	-1.6	-1.7	-1.0	-1.3	0.5	0.9
Medication for pain relief, constipation, heartburn	0.5	0.8	3.3	-0.5	1.8	-0.4	0.3	-0.8	-0.1	-1.1
Neck or shoulder pain in last month	0.1	0.2	0.6	-0.3	-0.2	-0.8	0.3	0.4	0.3	-0.6
Medication: Blood pressure	1.2	2.1	5.2	0.5	-2.3	0.6	-1.8	0.0	-0.7	2.2
Angina (self-reported)	0.7	0.9	2.7	-0.2	-1.6	-1.6	-0.5	-0.9	0.3	0.0
Migraine (self-reported)	0.4	0.5	2.3	-1.5	0.8	-0.1	0.4	0.4	0.1	-0.3
Medication: Ibuprofen	2.4	2.9	5.6	1.5	-1.4	0.7	-2.4	1.8	-2.3	1.1
Medication: Allopurinol	0.2	0.2	0.6	-0.8	0.5	0.3	0.1	0.2	0.1	0.7
Medication: Omeprazole	1.0	1.1	3.9	-1.3	-1.3	-0.5	-0.2	0.5	-0.1	2.0
Medication: Seretide 50 evohaler	2.0	2.3	8.6	-2.9	-0.5	-2.1	0.4	-0.7	0.9	1.3
Mean time to correctly identify matches	0.4	0.7	1.8	0.8	1.3	0.9	0.4	0.6	-1.0	0.2
Heart disease (mother)	0.3	0.3	1.2	0.4	-0.0	0.5	-0.4	1.1	-0.7	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	2.7	0.3	0.3	0.8	-0.5	1.6	-0.9	-0.4
Whole body fat mass	0.7	2.7	7.0	1.3	-2.1	-1.4	-2.6	-0.2	-1.2	1.6
Leg fat mass (right)	0.9	3.6	7.1	0.3	-2.5	-2.1	-2.7	-1.4	-1.2	1.9
Arm predicted mass (right)	0.5	2.8	5.1	2.0	-2.0	-1.1	-1.7	1.2	-0.7	2.3
Pulse rate, automated reading	0.4	1.3	2.5	-1.6	0.9	-0.9	1.1	-0.9	1.1	1.4
Alcohol intake frequency.	0.4	0.9	2.4	1.6	-0.0	-0.6	0.8	-1.2	0.9	-0.7
Comparative height size at age 10	0.6	3.6	14.1	3.2	0.6	0.4	-0.4	3.8	0.2	-0.1
Number of full sisters	0.7	0.8	2.3	0.9	-0.5	-1.1	-0.2	-1.5	-0.7	0.8
Suffer from ‘nerves’	0.4	0.7	2.2	1.0	-1.0	0.1	0.8	1.5	0.1	-0.1
Overall health rating	0.9	2.0	7.6	-0.2	-2.2	-0.2	-0.8	0.8	-0.4	2.8
Chest pain or discomfort	2.5	3.7	12.5	-0.7	-2.6	-3.5	-0.0	-1.6	0.5	1.8
Had major operations	0.9	1.1	2.6	0.7	-1.0	1.2	0.4	-1.4	1.6	0.0
Age at last live birth	0.8	1.1	4.2	2.1	0.9	-0.9	1.3	0.1	0.7	0.2
Family relationship satisfaction	1.5	1.8	5.2	0.1	2.3	1.6	-0.2	1.6	-1.0	-1.1
Leg pain on walking	0.3	0.3	1.4	-1.2	0.0	-0.8	-0.1	0.5	-0.3	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.4	1.0	-0.9	1.0	-0.2	1.2	0.4	0.8
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.4	-0.2	0.9	1.1	0.9	0.0	0.1	-1.2
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.9	-0.5	1.0	-1.0	-0.2	-0.4	0.6	0.2
Medication: Aspirin	1.1	1.5	5.7	0.3	-2.4	0.0	0.4	-0.6	1.0	1.7
Supplements: Vitamin C	0.8	0.9	2.2	1.5	0.2	1.3	-0.3	-0.8	-0.6	-1.2
Knee pain experienced in last month	0.3	0.5	0.9	-0.3	-0.1	-0.8	-0.8	-0.9	-0.4	-1.0
Hypertension (Self-reported)	1.3	3.5	8.0	1.2	-2.1	0.9	-1.6	2.8	-0.5	2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	3.2	-0.5	0.5	0.7	-0.2	1.8	-0.1	0.5
Illnesses of father: Heart disease	1.5	2.1	4.2	0.9	1.5	0.7	2.0	-1.7	1.2	-1.6
Illnesses of siblings: Diabetes	0.7	0.8	2.0	0.7	0.3	-0.2	1.0	-1.4	0.9	-1.2
Smoking status: Previous	0.5	0.7	1.9	1.0	0.5	0.3	0.7	-1.4	-0.3	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.2	8.3	2.9	-0.3	0.5	1.3	2.1	0.8	0.6
Whole body fat-free mass	0.5	2.8	5.7	2.4	-1.7	-1.1	-1.6	1.7	-0.5	2.1
Leg fat-free mass (right)	0.6	3.3	7.3	2.7	-1.7	-0.3	-2.0	1.9	-1.0	2.0
Arm fat percentage (left)	0.7	2.8	6.9	0.3	-2.4	-1.2	-2.6	-1.1	-1.1	1.6
Average weekly red wine intake	2.0	2.9	10.3	-1.7	1.0	2.3	0.5	3.2	-0.3	-0.8
Handedness (chirality/laterality): Left-handed	0.9	1.0	2.2	0.4	-0.8	-1.0	-1.5	-1.3	0.4	1.1
Mood swings	0.5	0.9	2.8	1.3	-0.3	-1.1	0.5	1.7	0.3	0.6
Loneliness, isolation	1.2	1.6	4.5	0.2	-2.1	-1.6	-0.9	0.7	-0.8	1.4
Long-standing illness, disability or infirmity	0.8	1.2	4.8	0.3	-2.2	-0.4	-0.1	0.6	0.9	1.6
Ever had bowel cancer screening	0.7	0.8	3.1	1.1	-1.8	0.9	-0.3	0.5	0.1	-0.5
Diabetes diagnosed by doctor	0.3	0.5	1.5	1.2	-0.9	-0.3	-0.5	0.7	-0.2	0.6
Ever had stillbirth, spontaneous miscarriage or termination	3.6	3.8	7.0	-1.1	-2.6	-2.3	-2.5	0.2	-0.5	2.6
Friendships satisfaction	0.5	0.6	3.1	-0.1	1.7	0.2	0.3	0.2	-0.5	-1.0
Qualifications: nursing, teaching	0.2	0.4	0.8	-0.7	0.9	0.8	-0.1	0.3	-0.4	-0.5
Commuting to job workplace: Walk	0.5	0.6	1.3	0.2	0.8	-0.1	1.1	-1.1	0.9	-0.2
Eye problems/disorders: Cataract	1.7	1.9	4.3	1.6	1.5	1.6	2.1	0.6	0.2	-1.3
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.0	0.8	-1.0	-0.4	-0.9	1.1	-1.2	1.4
Medication for cholesterol	0.6	0.8	3.5	-0.5	0.6	0.6	0.9	-1.9	0.5	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	4.3	0.4	-0.4	-1.3	-2.1	0.3	-0.9	-0.3
Back pain experienced in last month	0.2	0.3	1.0	-0.3	-0.6	-1.0	-0.3	0.7	0.2	-0.4
Mineral and other dietary supplements	0.8	1.1	2.7	-1.6	-0.2	-1.4	0.2	0.1	-0.1	1.6
Breast cancer (self-reported)	0.8	1.0	1.8	-1.3	0.3	1.3	1.1	1.2	0.7	-0.3
Asthma (self-reported)	1.6	3.1	9.5	-3.1	-0.8	-2.4	0.2	-2.3	0.6	0.1
Osteoporosis (self-reported)	1.0	1.2	3.2	0.6	-0.4	0.3	-1.7	1.8	-0.9	-1.0
Osteoarthritis (self-reported)	0.7	0.9	2.9	-1.0	-0.6	-1.7	-0.9	-1.2	-0.2	0.3
Medication: Aspirin	1.9	2.5	7.6	0.1	-2.8	-0.2	0.6	-0.4	1.7	2.4
Medication: Gliclazide	0.6	0.7	1.9	0.9	0.2	1.4	-0.9	0.9	-0.8	0.0
Illnesses of father: None of the above (group 1)	0.6	0.7	1.7	-1.3	0.2	0.2	-0.4	1.3	-1.0	0.6
Smoking status: Current	1.4	2.2	6.9	1.2	-1.3	-1.7	-1.4	-0.7	-0.1	2.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	1.1	-0.4	-0.2	1.0	-0.9	-0.3	-0.2	-0.1
Whole body water mass	0.5	3.0	5.7	2.4	-1.8	-0.9	-1.7	1.8	-0.6	2.1
Leg predicted mass (right)	0.6	3.3	7.7	2.8	-1.7	-0.3	-1.9	2.0	-0.9	1.9
Arm fat mass (left)	0.7	3.0	7.7	1.0	-2.5	-1.3	-2.8	-0.4	-1.2	1.8
Number of self-reported non-cancer illnesses	0.2	0.4	1.8	-0.2	-1.4	-0.2	-0.2	0.1	0.7	-0.5
Average weekly champagne plus white wine intake	0.6	0.9	2.4	-1.0	-0.6	1.6	-0.1	0.9	0.7	0.9
Miserableness	1.1	1.8	4.5	-1.0	-1.9	-2.1	0.4	-0.0	1.5	1.2
Guilty feelings	0.2	0.3	0.9	0.5	-0.4	0.6	0.5	0.9	-0.2	0.2
Wears glasses or contact lenses	2.8	3.2	7.6	-0.7	2.2	-0.4	2.2	-2.8	0.5	-2.1
Ever taken oral contraceptive pill	0.8	0.9	2.1	-0.3	-1.3	0.4	-1.0	0.8	-0.4	1.5
Hearing aid user	1.1	1.2	4.9	0.8	-1.3	-2.2	-0.0	-0.7	0.1	0.9
Mother’s age at death	0.6	0.8	2.4	-0.3	-0.9	1.2	-1.5	-0.2	-0.7	-0.4
Financial situation satisfaction	1.5	1.9	4.1	-1.7	-1.8	-0.9	-1.2	0.8	-0.5	2.0
Tinnitus: Yes, now most or all of the time	0.5	0.5	1.3	0.9	0.3	1.1	-0.4	0.9	-0.8	-0.3
Commuting to job workplace: Public transport	0.2	0.2	0.8	0.6	-0.3	-0.9	-0.1	-0.2	0.5	0.2
Eye problems/disorders: Glaucoma	1.5	1.8	3.4	1.5	-1.2	1.3	-1.8	1.1	-1.6	-0.0
Medication: Blood pressure	1.8	3.4	18.4	1.1	-0.4	1.2	-0.9	4.3	-0.5	1.0
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.4	-0.1	-1.0	0.8	-1.0	1.4	-1.6	-0.4
Supplements: Fish oil (including cod liver oil)	2.5	3.2	8.5	2.2	1.3	2.9	-0.1	-0.1	0.5	-2.7
High cholesterol (Self-reported)	0.3	0.6	1.4	0.0	0.0	0.2	-1.1	1.0	-0.8	1.2
Medication: Bendroflumethiazide	0.4	0.6	1.4	1.2	-0.7	0.7	-0.2	0.9	0.4	0.8
Medication: Paracetamol	0.2	0.3	1.1	0.5	-0.3	1.1	-0.2	0.4	-0.1	0.2
Medication: Lisinopril	0.9	1.2	4.0	-0.7	0.4	0.6	-2.0	1.2	-1.4	0.1
Medication: Atorvastatin	1.2	1.5	5.8	0.1	-0.9	-2.4	1.1	-0.8	1.0	0.9
Illnesses of father: High blood pressure	1.2	1.4	3.7	-0.8	-1.7	-0.8	-1.9	0.5	-1.0	0.8
Alcohol drinker status: Never	1.8	2.2	5.5	-2.0	0.5	-0.2	2.4	-1.6	1.7	-0.1
Ever smoked	0.7	1.1	2.8	1.3	-0.5	-0.6	-1.7	-1.2	-0.9	0.7
Basal metabolic rate	0.6	3.2	5.7	2.4	-2.0	-1.2	-2.0	1.4	-0.7	2.2
Leg fat percentage (left)	1.1	3.8	8.7	-1.3	-1.8	-2.5	-2.1	-3.0	-0.5	1.4
Arm fat-free mass (left)	0.5	2.3	4.4	2.1	-1.8	-1.1	-1.7	1.0	-0.5	1.7
Number of operations (self-reported)	0.3	0.5	1.4	0.1	-0.9	0.8	-0.0	-1.2	0.6	-0.4
Average weekly beer plus cider intake	1.0	1.5	4.7	0.6	-0.6	-2.0	0.9	0.2	0.5	2.2
Irritability	0.9	1.5	5.9	1.3	-0.0	0.6	1.3	2.4	0.8	-0.4
Risk taking	1.1	1.7	4.1	-0.3	-0.3	1.0	-1.5	2.0	-2.0	0.0
Ever had prostate specific antigen (PSA) test	0.8	0.9	3.3	1.3	-0.9	1.8	-0.5	0.4	-0.1	0.6
Fractured/broken bones in last 5 years	0.5	0.6	1.9	-1.4	-1.0	-0.3	-0.7	0.1	-0.8	0.4
Age started oral contraceptive pill	0.5	0.7	1.6	-1.3	0.6	-0.5	0.8	-0.1	0.8	-1.1
Diastolic blood pressure, automated reading	0.7	2.2	12.1	-0.9	-0.1	1.0	-0.3	3.5	-0.4	1.0
Ever depressed for a whole week	0.4	0.5	1.4	-0.1	-0.9	0.2	-0.9	1.2	-0.4	0.3
Unable to work because of sickness or disability	1.2	1.6	3.9	-0.2	-0.2	-2.0	1.7	-1.5	1.4	0.1
Commuting to job workplace: Cycle	0.9	1.0	2.2	1.2	-0.3	1.2	-0.4	1.5	-0.7	-1.3
Myopia	0.2	0.3	0.7	-0.8	-0.8	0.4	-0.0	0.2	0.2	-0.6
Vascular/heart problems diagnosed by doctor	1.1	2.9	5.3	-1.0	2.1	-0.6	2.0	-2.3	0.9	-2.0
Cholesterol lowering medication	0.3	0.5	2.3	-0.5	0.3	-1.5	0.3	-0.1	0.5	0.4
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.7	-1.6	-0.8	0.0	1.0	0.2	0.2	1.1
Pain experienced in last month	0.3	0.4	1.2	0.9	0.5	0.8	-0.2	-1.1	0.1	0.0
Supplements: Calcium	1.2	1.3	3.9	1.5	-0.6	1.3	-0.7	2.0	-0.6	-0.4
Basal cell carcinoma (self-reported)	3.1	3.7	11.8	3.4	0.9	2.9	0.6	1.8	-0.7	-0.6
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.4	-0.5	-0.1	-0.5	-0.2	0.7	-0.5	0.6
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.3	-0.0	-0.3	-0.5	0.1	-1.2	-0.5	-0.9
Heart disease (siblings)	0.7	0.8	2.8	0.4	0.6	0.5	-0.6	0.3	-1.7	-1.4
Alcohol drinker status: Previous	0.8	0.9	3.5	0.3	0.3	-0.6	1.9	-0.9	0.9	-1.0
Pack years of smoking	0.2	0.3	0.7	-0.6	0.1	-0.6	-0.0	-0.7	0.0	0.9
Impedance of whole body	0.6	3.1	6.1	1.1	2.5	1.9	1.7	1.6	0.6	-2.3
Leg fat mass (left)	0.9	3.4	7.2	0.4	-2.4	-2.0	-2.7	-1.3	-1.1	1.9
Arm predicted mass (left)	0.5	2.6	4.4	1.9	-1.8	-1.3	-1.8	1.3	-0.6	2.1