Hub : Genes

CYP1B1-AS1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1550	0.0390	3.8e-07	0.009	0.084	0.056	0.083	0.048	2.2e-02	2.0e-10	2.1e-07	2.3e-10	1.5e-06
2	GTEx	Artery Tibial	0.1430	0.0453	4.1e-04	0.024	NA	0.023	NA	0.035	5.1e-03	NA	6.4e-03	NA	9.3e-04
3	GTEx	Muscle Skeletal	0.0789	0.0285	1.2e-03	0.000	NA	0.001	NA	0.001	3.6e-01	NA	2.8e-01	NA	2.7e-01
4	GTEx	Nerve Tibial	0.2079	0.0574	1.3e-04	0.036	NA	0.064	NA	0.062	1.4e-03	NA	2.4e-05	NA	3.3e-05
5	GTEx	Spleen	0.2610	0.1010	5.8e-03	0.003	NA	0.010	NA	0.038	2.7e-01	NA	1.8e-01	NA	3.8e-02
6	GTEx	Whole Blood	0.1450	0.0430	2.5e-05	0.078	NA	0.095	NA	0.114	1.1e-07	NA	4.5e-09	NA	1.1e-10
7	ROSMAP	Brain Pre-frontal Cortex	0.0734	0.0310	5.4e-03	0.031	0.007	0.047	0.022	0.044	6.0e-05	3.5e-02	1.1e-06	6.1e-04	2.2e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.4	0.6	2.2	0.9	0.5	0.9	1.5	-0.3	-0.5	-0.1
Bipolar Disorder or Schizophrenia	0.2	0.5	2.7	0.2	-1.6	0.5	-0.5	-0.2	0.2	-0.5
Depressed Affect (Nagel 2018)	0.3	0.7	1.8	0.4	0.4	-1.3	-0.5	0.8	1.3	0.1
Depression (Nagel 2018)	0.9	1.4	2.6	-1.3	0.7	-1.5	-1.6	-1.1	-0.3	-1.1
Intelligence (Savage-Jansen 2018)	0.3	1.0	3.2	1.8	-0.8	-1.0	0.1	-0.9	-0.3	0.9
Neuroticism (Nagel 2018)	0.4	1.0	2.4	0.9	0.8	-0.6	0.7	1.4	1.6	0.7
Schizophrenia (2018)	0.7	1.5	6.4	-0.5	-2.5	-0.1	-1.8	-0.0	0.6	-0.5
Schizophrenia vs Biploar Disorder	1.5	2.0	7.7	-0.6	-0.9	-1.2	-0.7	-1.4	-1.2	-2.8
Worry (Nagel 2018)	0.9	2.0	3.4	1.8	-0.2	0.2	1.7	1.6	1.8	1.3
Alzheimer’s Disease (in mother)	1.1	1.2	3.0	-1.0	1.7	1.5	-1.1	0.1	0.9	-0.5
Alzheimer’s Disease (in father)	0.3	0.4	1.1	-0.9	0.5	0.4	-1.1	-0.2	-0.4	0.0
Alzheimer’s Disease (including proxy)	0.9	1.4	3.1	-1.4	1.1	1.7	-1.7	-0.0	0.2	-0.5
Crohns Disease (2017)	0.3	0.6	2.6	-0.0	-0.5	-0.3	0.3	-0.7	-1.6	-0.7
Irritable Bowel Disease (IBD)	0.1	0.3	0.9	-0.6	-0.6	0.0	0.6	0.3	-0.1	-0.9
Ulcerative Colitis (UC)	0.4	0.8	1.9	-1.2	-0.3	0.2	0.6	1.1	1.4	-1.0
Major Depression (MDD)	1.9	2.3	5.9	-0.6	1.4	2.4	1.5	1.9	1.2	0.2
Reaction Time	1.1	2.0	7.7	-2.8	1.2	-0.5	-1.4	1.1	1.0	-0.9
Verbal and Numeric Reasoning (VNR)	0.3	0.7	2.2	1.1	-0.7	-0.1	-1.0	-0.7	-0.1	1.5
Breast Cancer	0.1	0.3	0.5	0.2	-0.6	0.7	-0.6	0.4	-0.7	0.5
Ovarian Cancer	0.3	0.4	1.3	0.1	0.8	1.1	0.5	-0.2	-0.5	0.3
Prostate Cancer	0.5	0.7	2.0	-0.7	-0.0	1.1	0.8	0.9	1.4	0.4
Age at First Birth	1.6	2.3	6.7	-1.9	2.6	0.2	0.4	1.2	1.3	-1.6
Bipolar Disorder (2011)	0.7	0.7	1.8	-0.6	0.9	1.3	-0.6	-1.0	-0.5	-0.7
Body Mass Index (BMI) (2010)	0.6	0.8	1.8	-0.8	1.3	0.8	0.7	0.9	0.9	-0.7
Coronary Artery Disease (CAD)	0.9	1.0	2.2	0.3	0.4	0.9	1.5	1.5	1.4	0.2
Crohns Disease (2012)	0.5	0.9	1.9	0.6	-0.6	0.3	1.0	-0.7	-1.4	-1.4
Mean Putamen Volume	0.8	0.9	3.2	0.3	1.8	-0.8	1.0	0.2	0.8	-0.8
Fasting Glucose	1.4	1.6	5.6	-0.4	0.4	1.1	0.5	1.9	2.4	0.6
HbA1C	0.9	1.0	2.5	1.1	-1.6	-0.2	1.2	1.0	0.6	0.7
HDL Cholesterol	0.3	0.5	2.3	-0.3	0.0	-1.5	-0.1	0.8	0.5	0.0
LDL Cholesterol	0.1	0.2	0.6	-0.8	0.0	-0.2	-0.1	-0.1	-0.3	-0.8
Lupus	0.5	0.7	1.3	-0.1	-0.9	1.1	1.1	0.8	0.8	-0.6
Neuroticism (2016)	0.3	0.4	0.8	0.5	0.6	0.9	0.6	0.3	0.5	0.7
Primary Biliary Cirrhosis	1.7	2.4	7.5	2.1	0.3	-0.9	2.7	1.0	1.7	-0.5
Rheumatoid Arthritis	0.6	0.9	1.8	0.3	-0.3	1.0	1.3	-0.4	-1.2	1.2
Schizophrenia (2014)	0.6	1.3	7.1	-0.1	-2.7	0.1	-0.9	-0.4	-0.2	-1.0
Triglycerides	1.4	2.3	6.5	-1.7	1.2	1.0	-0.3	2.0	2.5	-0.3
Type 2 Diabetes (T2D) (2012)	1.0	1.1	4.7	0.5	0.2	0.7	2.2	1.2	0.8	-0.2
Ulcerative Colitis	0.5	0.7	1.8	-0.9	-0.8	0.2	0.3	0.6	1.1	-1.3
Blood Eosinophil Count	0.8	6.2	19.3	2.7	-4.4	0.1	-2.3	-2.8	-2.0	0.0
Blood Platelet Count	0.4	4.3	14.3	0.3	0.9	3.8	-0.4	1.7	0.9	3.3
Blood Red Count	0.0	0.2	0.8	0.2	0.3	0.3	0.4	0.2	0.9	-0.5
Blood White Count	0.2	1.6	3.3	1.8	-1.6	-0.9	-1.0	-1.7	-0.8	0.0
Heel T-Score	0.0	0.3	1.5	-0.6	-0.3	-0.1	1.2	0.5	0.3	0.0
BMI	0.8	4.9	13.0	1.3	0.0	-3.1	-0.1	-3.6	-3.0	-0.9
Height	0.4	8.4	23.3	-3.8	4.8	3.0	1.7	1.2	0.4	2.7
Waist Hip Ratio (WHR)	0.2	0.9	3.0	-1.1	0.1	0.3	0.8	0.7	1.0	1.7
Systolic Blood Pressure	0.5	2.3	6.4	-2.1	-0.4	2.5	1.4	1.4	1.0	0.2
Smoking Status	0.7	1.8	3.9	-0.9	1.5	-2.0	-1.4	0.6	0.9	-1.6
Allergy or Eczema	0.6	1.5	2.7	-1.6	1.1	1.1	0.7	0.8	1.4	-1.6
Cardiovascular Disease	1.0	3.4	7.0	-2.6	2.7	0.4	2.3	0.3	0.7	-2.1
Hypothyroidism (self reported)	0.5	1.0	3.8	2.0	-0.8	-0.3	-1.0	-0.6	0.2	1.1
Respiratory disease	2.2	5.0	15.3	2.3	-2.5	0.5	-3.9	-2.2	-1.7	0.4
Type 2 Diabetes (T2D) (2018)	0.5	0.9	3.1	-1.1	1.8	-0.9	0.7	-0.4	-0.3	-0.8
Lung FEV1/FVC ratio	0.6	3.2	9.9	-0.5	3.1	-1.0	2.3	1.4	1.0	1.7
Lung FVC	0.7	3.5	9.5	2.3	-0.2	-3.1	-1.0	-2.5	-1.5	-0.3
Neuroticism	0.5	1.3	4.5	0.2	0.8	-0.0	0.6	1.7	2.1	0.6
Chronotype (morning person)	0.6	1.3	3.3	-1.5	0.2	1.8	0.3	0.9	0.6	-1.5
Hair Pigment	0.0	1.2	3.4	-0.1	1.9	0.5	-1.8	-0.6	-0.7	-0.9
Tanning	1.8	21.6	98.8	3.7	-9.9	-0.3	-5.1	-2.6	-0.6	-2.2
Hand grip strength (left)	0.6	1.6	5.7	0.7	-0.9	-0.6	-0.4	-2.4	-1.6	-0.9
Number of treatments/medications taken	1.0	1.8	4.8	-1.2	0.8	0.3	2.2	1.5	1.8	0.5
Average weekly spirits intake	1.4	1.8	5.4	-0.2	0.2	-2.3	-0.5	-1.7	-1.7	-1.0
Sensitivity / hurt feelings	0.2	0.4	1.3	-0.5	-0.5	-0.6	-0.5	-0.4	-0.6	-1.1
Frequency of depressed mood in last 2 weeks	1.0	1.3	3.0	-1.1	-0.0	-1.0	-1.7	-1.5	-1.1	-0.8
Hearing difficulty/problems: Yes	0.3	0.4	1.2	0.3	-1.1	0.1	-0.5	-0.1	-0.2	1.1
Relative age of first facial hair	1.0	2.0	6.0	1.0	-0.7	-0.5	-1.4	-1.9	-2.5	-0.7
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	5.0	-0.2	0.9	-0.6	2.2	-0.0	0.9	-0.6
Ever used hormone-replacement therapy (HRT)	1.2	1.5	5.3	0.2	2.0	-0.1	2.3	-0.3	0.8	0.7
Ever had hysterectomy (womb removed)	0.9	1.1	3.4	0.6	0.8	1.0	1.8	0.8	1.2	0.4
Systolic blood pressure, automated reading	0.5	1.5	4.7	-1.4	-2.2	1.7	0.4	-0.5	-0.8	0.0
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.3	-1.2	0.4	0.5	-0.6	-0.1	-0.5	-0.9
Angina	0.4	0.6	2.7	0.5	-0.0	-1.6	-0.1	-0.0	0.2	1.0
Medication for hormone replacement therapy	0.2	0.3	0.9	0.2	0.7	0.4	-1.0	-0.3	0.0	0.4
Vitamin and mineral supplements	1.4	1.9	5.7	1.1	-1.2	-1.2	0.8	-1.2	-1.2	2.4
Supplements: Zinc	0.7	0.8	2.4	-0.2	-1.6	-1.0	-0.7	-1.0	-0.6	-0.1
Medication: Co-codamol	0.2	0.2	0.5	-0.0	-0.7	0.4	-0.0	-0.7	-0.7	0.4
Medication: Metformin	0.6	0.9	4.0	-0.3	-0.5	0.1	2.0	0.6	0.1	1.2
Diabetes (father)	1.5	1.8	4.6	-1.2	2.1	-0.1	1.8	1.2	1.4	0.0
Diabetes (mother)	0.9	1.2	4.7	0.5	0.4	-2.2	-0.4	0.6	1.4	-0.6
Severe depression (siblings)	1.0	1.1	2.8	0.4	-0.4	-0.9	-1.4	-1.7	-1.3	-0.0
Pack years adult smoking proportion	0.5	0.7	1.8	0.6	-0.6	-1.2	-0.8	-0.7	-1.3	0.0
Impedance of leg (right)	0.1	0.6	3.6	-0.2	0.4	0.5	-1.9	-0.2	0.2	-0.1
Leg fat-free mass (left)	0.3	1.8	3.8	-1.0	1.9	-0.6	1.2	-1.6	-1.9	0.1
Trunk fat percentage	0.3	1.0	2.0	0.3	0.9	-1.4	1.3	-1.2	-1.1	-0.1
Hand grip strength (right)	0.2	0.6	1.7	-0.2	-0.4	0.4	0.2	-1.3	-0.8	-1.3
Townsend deprivation index at recruitment	1.1	1.6	5.1	2.3	0.3	-1.4	1.3	0.6	0.1	1.4
Current tobacco smoking	0.9	1.5	4.6	-1.1	0.8	-2.1	-1.1	-1.2	-0.1	-1.2
Average weekly fortified wine intake	1.7	2.0	3.7	-0.9	-0.1	1.7	-1.4	0.9	1.9	-1.8
Maternal smoking around birth	1.7	2.5	8.8	-0.0	-0.6	-1.0	1.0	-2.3	-3.0	-1.1
Fed-up feelings	0.6	1.0	3.5	-0.5	0.0	-1.1	-1.9	-0.8	-1.3	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	5.8	-0.0	-0.8	-0.9	-2.4	-1.9	-1.5	-0.7
Relative age voice broke	0.6	0.9	2.6	-0.5	-0.1	1.6	0.2	1.2	1.1	-1.0
Taking other prescription medications	0.6	0.9	5.0	0.0	-0.4	-0.9	-0.1	0.2	0.7	2.2
Age when periods started (menarche)	0.2	0.5	1.4	0.5	-0.5	0.5	-0.8	-0.7	-1.2	-0.5
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.6	0.9	1.0	-1.6	0.6	-0.5	0.1	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.4	-0.3	-0.6	0.4	-0.0	0.2	0.6	-0.2
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	4.5	0.4	-2.1	0.0	-1.2	-0.9	-1.0	-0.9
Qualifications: CSEs or equivalent	1.0	1.3	3.5	-0.1	0.3	-1.1	-0.2	-1.6	-1.9	-1.4
Serious illness, injury or assault to yourself	0.2	0.2	0.6	-0.7	-0.8	-0.2	-0.3	0.3	0.4	-0.5
High blood pressure	1.1	3.2	10.4	-2.1	1.4	0.5	3.2	1.8	1.4	0.6
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.4	-1.2	1.1	0.8	0.8	0.4	0.7	-1.2
Multivitamins +/- minerals	2.3	2.9	6.8	-1.4	-0.1	2.1	-0.3	1.7	2.1	-2.6
Stomach or abdominal pain in last month	1.3	1.7	4.7	-1.5	0.9	1.4	-2.2	0.2	0.9	-1.1
Supplements: Glucosamine	0.9	1.1	4.2	-0.3	-0.3	1.6	0.6	-0.7	0.2	-2.0
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	3.1	0.4	0.5	0.6	0.8	1.4	1.8	-1.8
Medication: Atenolol	1.9	2.4	7.3	-1.2	0.0	1.2	1.0	2.7	2.1	1.2
Medication: Levothyroxine sodium	0.5	0.9	2.3	1.0	-0.2	-1.0	-1.5	-0.2	0.9	-1.0
Sitting height	0.6	4.2	15.6	-1.8	4.0	2.7	0.4	-0.6	-1.6	0.5
Chronic bronchitis/emphysema (father)	1.7	1.9	8.4	1.5	-2.9	-0.0	-0.9	-0.9	-1.2	-0.0
High blood pressure (mother)	0.6	0.8	2.4	-0.8	-1.1	0.8	1.5	0.5	0.4	-0.4
Body mass index (BMI)	0.9	3.8	8.4	0.8	-0.8	-2.8	0.8	-2.9	-2.8	-0.7
Impedance of leg (left)	0.1	0.5	1.5	-0.3	0.6	0.5	-1.2	0.4	0.8	0.4
Leg predicted mass (left)	0.3	1.8	3.6	-1.1	1.9	-0.6	1.3	-1.5	-1.9	0.1
Trunk fat mass	0.4	1.5	2.5	0.0	1.3	-1.4	1.4	-1.6	-1.6	-0.2
Waist circumference	0.7	2.6	6.8	-0.1	0.2	-2.6	0.6	-2.4	-2.2	0.5
Number of incorrect matches in round	0.7	1.2	2.7	-0.0	0.8	1.6	1.6	1.3	0.7	0.1
Past tobacco smoking	0.7	1.3	2.2	0.7	-1.5	1.2	0.8	-0.6	-1.4	1.5
Alcohol usually taken with meals	2.3	3.7	11.4	1.0	0.5	3.4	1.2	2.7	1.5	1.6
Nervous feelings	0.1	0.2	0.6	0.0	-0.6	-0.3	0.5	0.7	0.6	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.0	-1.0	-1.0	0.1	-0.4	0.6	0.7	0.1
Hearing difficulty/problems with background noise	0.8	1.2	2.7	1.4	-1.4	1.1	0.0	0.8	0.3	1.6
Hair/balding pattern: Pattern 2	0.2	0.3	1.3	-1.1	0.2	0.1	0.7	-0.0	0.2	-0.5
Had menopause	0.7	0.9	3.5	0.8	-1.1	1.9	-0.1	0.3	0.2	0.8
Had other major operations	1.1	1.3	3.3	1.8	-1.3	0.1	-0.3	1.4	1.3	0.7
Forced vital capacity (FVC)	0.3	1.3	6.4	0.0	2.5	-1.1	-0.8	-0.6	0.1	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.9	-0.8	-0.0	0.4	0.7	0.1	0.4	-0.9
Ever unenthusiastic/disinterested for a whole week	1.7	2.0	4.4	-2.1	-0.2	0.7	-1.1	2.0	1.8	-1.1
Qualifications: None of the above	0.2	0.4	1.1	0.5	-0.1	0.3	-1.1	-0.8	-1.0	0.2
Financial difficulties in last 2 years	0.1	0.1	0.3	-0.3	0.0	-0.2	-0.4	0.0	-0.5	0.4
Mouth/teeth dental problems	0.2	0.3	1.1	-0.8	-0.5	-0.4	-0.4	-0.0	0.1	-1.1
Heart attack	0.4	0.5	2.2	-0.1	0.0	1.5	-0.5	0.5	0.8	0.3
Allergy	0.3	0.8	2.2	0.3	-0.3	-0.3	1.2	1.0	0.6	1.5
Pain all over the body in last month	1.1	1.1	3.8	-1.1	0.0	-0.5	0.8	1.3	2.0	-0.6
Diabetes (self-reported)	0.3	0.5	1.9	-0.4	0.2	0.8	1.4	0.7	0.2	0.7
Hayfever/allergic rhinitis (self-reported)	1.0	1.4	2.6	-1.5	-1.6	-0.9	-1.4	-0.5	-0.5	-1.2
Medication: Ramipril	1.8	2.3	7.8	-0.5	1.5	0.3	2.8	1.5	1.5	1.0
Medication: Simvastatin	0.5	0.8	1.5	0.8	-0.3	-1.2	0.9	1.0	1.0	0.8
Fluid intelligence score	0.4	0.8	3.2	1.8	-0.4	0.5	0.1	0.3	0.4	1.2
Illnesses of siblings	0.4	0.6	1.3	1.0	-0.3	-0.9	-1.1	-0.6	-0.8	0.1
Neuroticism score	0.2	0.4	1.1	0.2	0.8	-0.5	0.2	0.9	1.1	0.1
Weight	0.5	2.7	7.2	-0.3	1.4	-1.4	1.1	-2.5	-2.7	-0.2
Impedance of arm (right)	0.8	3.7	8.0	-1.5	2.3	2.8	-0.5	2.5	2.1	0.2
Arm fat percentage (right)	0.4	1.4	3.3	0.1	0.2	-1.8	0.7	-1.7	-1.6	-0.6
Trunk fat-free mass	0.4	2.2	6.9	-0.8	1.6	-0.4	0.3	-2.3	-2.6	0.3
Hip circumference	0.5	2.1	5.1	-0.1	1.1	-1.6	0.8	-2.3	-2.2	-0.4
Time employed in main current job	0.2	0.3	1.0	1.0	0.5	0.2	0.6	0.1	0.1	0.3
Alcohol intake versus 10 years previously	0.8	1.2	5.2	-0.0	2.3	-0.5	1.7	0.3	0.1	0.2
Father’s age at death	0.4	0.5	1.5	0.6	-0.1	0.5	-1.2	0.6	0.5	0.9
Worrier / anxious feelings	0.3	0.5	2.3	1.5	-0.3	-0.8	0.2	0.5	0.5	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	3.6	0.8	0.3	-1.5	0.1	-0.4	-0.5	1.9
Falls in the last year	0.6	0.8	2.1	-0.2	-0.0	1.3	0.3	1.1	0.9	1.4
Hair/balding pattern: Pattern 3	1.2	1.8	6.7	-1.0	0.5	1.3	0.5	2.6	1.7	0.0
Number of live births	1.1	1.5	5.0	1.6	-1.4	0.2	-0.2	-0.5	-0.7	2.2
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	10.4	-0.1	3.2	-1.2	0.2	-0.1	0.4	-0.1
Pulse rate	0.8	1.3	2.8	-0.5	-1.7	-1.4	-1.5	-1.1	-0.9	-0.1
Happiness	1.5	1.8	5.3	-1.2	0.9	2.3	0.1	1.6	1.6	-0.7
Noisy workplace	1.7	2.1	5.1	0.4	1.9	-1.0	1.3	-1.8	-2.2	-0.0
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.6	-0.0	-0.4	-0.5	-0.7	0.5	1.3	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.4	-0.7	0.9	-0.0	1.2	0.2	0.6	-0.5
Mouth/teeth dental problems: Dentures	1.1	1.9	7.8	2.8	-0.4	1.5	0.8	0.3	-0.0	1.5
Asthma	2.2	4.3	15.9	0.9	-2.2	-0.1	-4.0	-2.2	-2.0	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.2	-1.0	1.1	-0.1	1.0	-0.0	0.7	-1.1
Medication: Cholesterol lowering	2.0	3.1	8.5	1.0	1.3	-0.9	2.9	2.0	1.7	1.7
Depression (self-reported)	0.1	0.1	0.3	0.2	-0.4	-0.5	-0.4	0.2	-0.1	0.1
Medication: Lansoprazole	0.4	0.5	1.1	0.7	-0.7	-0.7	-0.2	-1.1	-0.4	-0.5
Prospective memory result	0.7	0.8	3.8	2.0	-0.7	-0.2	-0.8	0.5	0.1	0.8
Lung cancer (father)	0.7	0.8	2.6	0.1	0.3	0.8	-0.2	-1.6	-1.4	-0.3
Illnesses of mother	0.6	0.8	1.2	1.1	-0.3	-1.1	-1.0	-0.7	-1.0	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	9.5	0.7	3.1	-0.9	1.1	-0.5	-0.4	0.3
Pulse wave Arterial Stiffness index	0.5	0.6	2.1	0.3	1.3	0.0	1.4	0.4	-0.4	-0.4
Impedance of arm (left)	0.8	3.8	8.0	-0.7	1.9	2.7	-0.3	2.8	2.6	0.8
Arm fat mass (right)	0.5	2.0	4.1	-0.4	0.8	-1.9	0.8	-2.0	-2.0	-0.6
Trunk predicted mass	0.4	2.2	6.9	-0.7	1.6	-0.4	0.3	-2.2	-2.6	0.3
Standing height	0.5	5.4	21.2	-2.4	4.6	2.7	0.9	0.7	0.1	1.6
Length of working week for main job	1.3	1.5	5.2	1.9	-2.3	0.6	-0.3	0.4	-0.0	-0.8
Exposure to tobacco smoke at home	0.6	0.6	2.2	0.7	-0.3	-1.5	-1.2	0.1	-0.4	-0.0
Breastfed as a baby	1.2	1.5	3.3	-1.0	-0.1	1.6	-0.5	1.8	1.5	1.0
Tense / ‘highly strung’	1.3	2.2	6.3	0.3	1.4	2.5	1.9	1.1	1.3	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	4.7	0.6	-0.0	-2.2	-0.6	-0.3	0.1	0.5
Hair/balding pattern: Pattern 4	0.2	0.5	3.2	-0.0	0.3	-1.8	0.3	-0.5	-0.4	0.1
Birth weight of first child	0.4	0.8	2.2	-1.2	0.3	-0.3	-0.1	0.5	1.1	-1.5
Peak expiratory flow (PEF)	0.8	2.0	10.1	-0.5	3.2	-1.4	0.8	-0.3	-0.5	0.6
Pulse wave reflection index	1.5	1.9	5.2	2.3	1.4	-0.0	2.1	0.5	-0.1	1.0
Ever highly irritable/argumentative for 2 days	1.0	1.2	3.8	0.1	-0.4	-1.4	-1.9	-1.2	-0.8	-0.2
Loud music exposure frequency	0.6	0.7	1.4	-1.1	0.7	0.3	-0.5	1.1	1.2	-0.3
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.7	0.5	-0.5	0.4	-0.3	-0.1	0.9	-1.3
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	4.1	0.3	0.1	0.3	2.0	0.2	0.1	0.4
Blood clot in the leg (DVT)	0.7	0.9	3.1	-0.8	0.8	1.0	0.3	-0.5	-0.6	-1.8
Medication: Paracetamol	1.2	1.9	4.1	-1.5	1.3	0.0	1.6	1.2	2.0	-1.2
Headache pain in last month	0.8	1.5	2.6	-0.4	-0.4	1.6	-1.6	-1.4	-1.3	1.0
Medication for cholesterol, blood pressure or diabetes	1.6	2.7	6.3	0.3	-2.2	1.7	-2.5	-1.4	-1.1	-1.3
Glaucoma (self-reported)	0.9	1.1	2.4	1.0	1.4	-1.3	1.6	0.2	0.2	-0.4
Gout (self-reported)	0.8	1.1	3.7	-1.1	0.4	-1.9	0.9	0.0	0.2	-1.3
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	3.6	1.9	-1.3	-1.0	-1.4	-1.2	-0.4	0.7
Medication: Amlodipine	2.5	3.5	10.7	-3.3	0.7	-1.1	0.5	2.1	2.7	-0.8
Medication: Ventolin 100micrograms inhaler	2.7	3.5	11.1	1.2	-1.8	-1.3	-3.3	-2.1	-1.2	1.1
Birth weight	0.4	0.8	3.1	0.6	0.4	-1.8	-0.2	-1.4	-0.1	-0.2
Chronic bronchitis/emphysema (mother)	2.0	2.4	5.2	0.7	-1.6	1.8	-2.3	-1.2	-1.1	-1.5
High blood pressure (siblings)	0.8	1.1	2.5	-0.8	-0.4	1.4	1.6	1.1	0.9	0.4
Forced vital capacity (FVC), Best measure	0.6	2.1	5.1	1.1	2.2	-1.6	0.1	-1.8	-1.7	0.2
Body fat percentage	0.4	1.7	4.5	0.4	0.4	-2.1	1.0	-1.8	-1.6	-0.4
Leg fat percentage (right)	1.2	4.5	11.0	1.1	-1.1	-2.9	-0.1	-3.3	-2.9	-1.0
Arm fat-free mass (right)	0.5	2.4	6.1	-0.4	1.4	-1.2	1.4	-2.2	-2.5	0.5
Exposure to tobacco smoke outside home	0.6	0.8	2.7	0.2	-1.7	0.0	-0.6	-0.8	-0.2	-1.4
Comparative body size at age 10	0.5	1.5	3.8	0.9	-1.7	-2.0	-0.6	-0.8	0.1	-1.3
Number of full brothers	0.5	0.7	1.6	-0.9	0.3	0.5	0.5	1.2	1.3	0.4
Worry too long after embarrassment	0.7	1.1	2.8	-1.0	1.7	-1.1	0.4	0.9	1.3	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	2.0	0.3	-0.5	-1.4	-1.2	-0.4	0.1	-0.2
Wheeze or whistling in the chest in last year	1.5	2.7	8.3	0.3	-2.3	-0.9	-2.9	-1.3	-1.4	-0.9
Number of children fathered	1.1	1.3	4.7	-0.7	-0.4	0.0	0.6	-1.5	-2.2	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	3.3	1.8	0.3	-1.2	1.8	-0.2	-0.2	0.1
Age at first live birth	2.5	4.5	12.0	-2.2	3.5	1.5	-0.1	2.1	2.3	-1.6
Pulse wave peak to peak time	0.5	0.6	1.9	-0.4	-1.2	0.1	-1.4	-0.2	0.5	0.6
Health satisfaction	0.4	0.6	1.6	-1.3	-0.8	0.3	-0.4	0.8	0.1	-1.0
Shortness of breath walking on level ground	3.5	4.2	12.2	1.1	0.4	-1.8	-1.7	-3.1	-3.5	0.4
Qualifications: College or University degree	0.3	1.0	2.6	-0.8	-0.6	0.2	-0.9	1.6	1.5	-0.5
Eye problems/disorders: None of the above	0.8	1.0	2.6	1.3	-1.6	-0.6	-1.2	-0.7	-0.2	-0.0
Mouth/teeth dental problems: Loose teeth	0.5	0.5	2.1	0.5	-1.4	0.9	-0.8	0.1	0.4	-0.1
Emphysema/chronic bronchitis	0.6	0.7	2.5	-0.2	-1.0	-0.0	-0.5	-1.6	-0.8	-0.8
Medication for pain relief, constipation, heartburn	0.6	1.0	3.1	0.1	-0.9	0.9	-1.7	-0.8	-1.2	-0.3
Neck or shoulder pain in last month	0.4	0.6	2.8	-0.3	-0.3	0.5	-1.7	0.4	0.8	-0.6
Medication: Blood pressure	1.3	2.4	4.7	-1.3	1.2	-1.3	2.2	2.0	1.7	0.7
Angina (self-reported)	0.3	0.3	1.1	0.1	0.2	-1.1	0.3	0.4	0.5	0.8
Migraine (self-reported)	0.2	0.3	0.6	-0.3	-0.6	0.8	-0.1	-0.4	-0.4	0.7
Medication: Ibuprofen	1.0	1.2	3.3	-1.5	1.5	-0.1	0.9	-0.3	0.1	-1.8
Medication: Allopurinol	0.3	0.4	1.6	-1.3	-0.2	-0.3	0.2	-0.0	-0.9	-0.1
Medication: Omeprazole	2.3	2.8	4.5	1.3	-0.7	-1.9	-2.1	-1.5	-1.9	1.8
Medication: Seretide 50 evohaler	2.0	2.4	4.9	-0.2	-2.1	0.1	-2.2	-2.0	-1.7	-0.1
Mean time to correctly identify matches	1.1	2.0	7.5	-2.7	-0.0	-0.1	-1.5	1.6	1.4	-0.3
Heart disease (mother)	1.0	1.2	3.6	-0.3	0.4	0.4	1.8	0.8	0.9	1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	1.9	-1.0	-0.4	1.4	-0.1	0.7	0.9	-1.4
Whole body fat mass	0.5	2.0	4.0	-0.1	1.1	-1.9	1.2	-2.0	-1.9	-0.1
Leg fat mass (right)	0.9	3.5	8.4	0.1	0.3	-2.7	0.8	-2.9	-2.7	-0.7
Arm predicted mass (right)	0.4	2.1	4.7	-0.7	1.4	-1.4	1.1	-2.0	-2.2	0.5
Pulse rate, automated reading	0.4	1.3	3.9	-0.5	-0.8	-1.5	-2.0	-0.8	-0.9	-0.6
Alcohol intake frequency.	0.3	0.8	2.1	-0.9	1.5	-0.4	-0.5	-0.6	-1.0	-0.8
Comparative height size at age 10	0.5	2.7	7.6	-1.9	2.8	1.9	-0.2	-0.5	-0.9	1.9
Number of full sisters	1.2	1.4	3.4	-1.3	1.2	-1.9	-0.5	-0.4	0.3	-1.6
Suffer from ‘nerves’	0.3	0.5	1.1	-0.3	0.7	0.1	1.0	0.7	0.4	1.0
Overall health rating	0.6	1.2	2.6	-0.8	-0.2	-1.3	1.0	1.4	1.6	0.9
Chest pain or discomfort	1.7	2.5	6.6	-0.3	-0.4	-2.3	-2.6	-1.9	-1.1	-0.6
Had major operations	1.9	2.2	7.0	-0.1	1.0	-1.4	2.6	1.4	1.8	-0.6
Age at last live birth	1.1	1.6	5.9	-1.6	2.4	0.1	-1.1	0.5	0.8	-0.9
Family relationship satisfaction	0.4	0.5	1.9	-0.1	-0.1	1.4	0.4	0.8	-0.0	-0.8
Leg pain on walking	0.6	0.7	1.5	-0.6	-1.2	1.0	-0.3	0.4	1.2	-0.6
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	5.8	-0.1	1.1	-0.1	2.4	1.4	0.6	0.9
Commuting to job workplace: Car/motor vehicle	1.1	1.3	4.1	2.0	-0.6	0.7	1.8	0.5	-0.0	0.6
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.6	1.0	-0.4	-0.4	-1.2	-1.3	-1.1	0.8
Medication: Aspirin	1.3	1.7	4.5	-1.0	0.4	-1.2	2.1	1.4	1.7	0.1
Supplements: Vitamin C	0.3	0.4	0.8	0.4	0.9	-0.9	0.5	0.1	-0.3	-0.7
Knee pain experienced in last month	0.4	0.5	2.0	-0.4	0.1	1.2	0.3	-0.2	-0.3	-1.4
Hypertension (Self-reported)	1.4	3.9	12.2	-2.3	1.8	0.5	3.5	2.0	1.4	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	4.8	-1.0	-0.5	-0.2	-0.2	1.2	1.1	2.2
Illnesses of father: Heart disease	1.2	1.6	3.5	-1.6	1.7	0.8	-0.4	1.9	1.1	0.7
Illnesses of siblings: Diabetes	0.5	0.6	1.8	1.0	1.0	-0.0	0.3	-0.0	0.1	1.4
Smoking status: Previous	0.7	1.0	2.1	-0.4	1.4	0.1	-0.4	1.4	1.5	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.9	2.0	8.2	-0.6	2.9	0.7	0.6	-0.8	-1.5	1.1
Whole body fat-free mass	0.4	2.2	5.8	-1.0	1.8	-0.6	0.9	-2.0	-2.4	0.4
Leg fat-free mass (right)	0.3	1.7	3.6	-1.2	1.9	-0.5	1.6	-1.1	-1.5	0.4
Arm fat percentage (left)	0.4	1.4	3.8	0.4	0.3	-1.9	0.9	-1.6	-1.5	-0.6
Average weekly red wine intake	1.2	1.8	3.3	0.3	-1.6	1.6	1.6	1.8	0.6	1.0
Handedness (chirality/laterality): Left-handed	0.7	0.8	3.3	0.3	0.9	-1.8	-0.1	-0.9	-0.0	-0.8
Mood swings	0.2	0.3	1.4	-0.6	1.2	0.1	-0.3	0.2	0.7	0.1
Loneliness, isolation	1.0	1.4	3.8	-0.2	-0.4	-1.1	-0.9	-1.8	-1.9	-0.5
Long-standing illness, disability or infirmity	0.4	0.6	1.6	-1.3	0.6	-1.2	0.3	-0.2	-0.1	0.9
Ever had bowel cancer screening	0.8	0.9	3.7	0.9	0.6	-0.6	1.9	0.6	0.4	0.9
Diabetes diagnosed by doctor	0.3	0.5	2.1	-0.3	0.7	0.6	1.5	0.3	0.6	0.4
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.2	6.0	0.6	-1.0	-1.5	-0.9	-2.4	-2.2	0.1
Friendships satisfaction	0.4	0.5	1.8	-0.2	0.1	1.3	-0.3	0.2	0.2	-1.2
Qualifications: nursing, teaching	0.9	1.5	4.5	-1.1	-0.1	1.2	0.9	1.2	2.1	0.9
Commuting to job workplace: Walk	0.8	0.9	2.2	-1.5	0.5	0.1	-1.4	0.3	0.9	-0.9
Eye problems/disorders: Cataract	1.6	1.9	4.0	-2.0	1.3	1.1	1.1	1.6	0.9	-1.4
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	6.4	-2.5	1.3	-1.0	-0.7	-1.0	-0.5	-0.6
Medication for cholesterol	0.6	0.8	2.6	1.1	-0.7	-0.8	-1.6	0.1	-0.2	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.0	0.6	0.4	-0.5	-0.1	-0.9	-0.3	-1.0
Back pain experienced in last month	1.9	2.7	4.9	2.2	0.1	0.3	-1.8	-1.7	-2.0	2.0
Mineral and other dietary supplements	1.6	2.2	3.5	1.1	-1.8	-1.1	-0.5	-1.6	-1.9	1.8
Breast cancer (self-reported)	1.7	2.0	4.6	0.4	-1.0	1.6	0.9	2.1	2.0	0.6
Asthma (self-reported)	2.2	4.3	14.8	0.9	-2.4	-0.2	-3.9	-2.2	-1.9	-0.2
Osteoporosis (self-reported)	0.5	0.7	2.0	-0.8	0.3	1.4	0.8	0.4	0.7	0.8
Osteoarthritis (self-reported)	0.9	1.2	3.7	-0.9	-0.5	-0.5	-1.2	0.1	1.3	-1.9
Medication: Aspirin	1.1	1.5	4.2	-1.0	0.5	-1.6	2.0	1.0	1.0	0.5
Medication: Gliclazide	0.5	0.5	2.3	-0.2	0.8	0.6	1.5	0.4	0.1	0.5
Illnesses of father: None of the above (group 1)	0.6	0.8	2.0	0.6	-1.4	0.3	-0.1	-1.2	-1.1	-0.4
Smoking status: Current	1.2	1.8	4.2	-1.3	0.9	-2.0	-1.3	-1.2	-0.1	-1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	6.4	2.5	0.4	-1.6	1.5	-0.3	-0.1	-0.0
Whole body water mass	0.4	2.1	5.4	-1.0	1.8	-0.6	1.0	-1.9	-2.3	0.4
Leg predicted mass (right)	0.3	1.7	3.8	-1.2	1.9	-0.5	1.6	-1.2	-1.6	0.4
Arm fat mass (left)	0.5	2.0	4.1	0.1	0.8	-2.0	1.1	-2.0	-2.0	-0.3
Number of self-reported non-cancer illnesses	0.8	1.4	4.3	-0.6	0.2	-0.2	1.6	1.5	2.1	-0.3
Average weekly champagne plus white wine intake	0.6	0.9	2.7	1.6	-1.3	-1.1	0.2	0.5	-0.0	0.7
Miserableness	0.5	0.8	2.7	0.8	-1.0	-0.9	-1.6	-0.6	-0.3	0.2
Guilty feelings	0.4	0.6	1.4	0.9	0.3	-1.2	0.7	0.9	0.6	0.5
Wears glasses or contact lenses	1.7	1.9	6.1	-0.9	-0.0	0.4	-1.2	1.2	2.5	-1.9
Ever taken oral contraceptive pill	0.7	0.8	3.1	0.9	-0.8	-1.8	0.8	0.3	0.6	0.5
Hearing aid user	2.9	3.3	7.8	-1.7	0.8	-0.5	-0.9	-2.8	-2.5	-2.0
Mother’s age at death	0.5	0.6	1.3	0.7	-0.2	-1.1	0.3	1.0	1.0	0.7
Financial situation satisfaction	0.5	0.6	2.0	-0.0	-1.4	-0.3	-1.2	-0.7	-0.5	0.2
Tinnitus: Yes, now most or all of the time	0.7	0.8	3.1	-1.8	0.9	-1.1	0.3	0.8	0.4	-0.2
Commuting to job workplace: Public transport	1.1	1.3	4.2	-1.6	0.8	-0.2	-2.1	-0.6	-0.0	-1.2
Eye problems/disorders: Glaucoma	0.7	0.8	2.1	0.2	1.5	-1.1	1.1	0.6	0.7	0.2
Medication: Blood pressure	2.1	3.9	13.2	-1.0	0.8	1.9	3.6	1.3	1.0	2.6
Pain type(s) experienced in last month: Hip pain	0.3	0.3	1.4	-0.1	-0.1	0.4	0.2	1.2	0.4	0.8
Supplements: Fish oil (including cod liver oil)	4.0	5.2	10.6	-1.3	2.4	2.2	1.6	3.1	3.3	-1.2
High cholesterol (Self-reported)	0.1	0.1	0.2	-0.2	0.0	-0.5	0.5	-0.1	0.3	-0.3
Medication: Bendroflumethiazide	1.7	2.6	9.7	-0.9	1.2	0.9	3.1	1.0	0.8	1.9
Medication: Paracetamol	2.2	3.4	6.8	-2.2	1.5	0.5	1.8	1.8	2.6	-1.9
Medication: Lisinopril	0.3	0.4	1.2	-0.2	-0.3	0.7	0.9	0.2	0.2	1.1
Medication: Atorvastatin	0.6	0.8	1.6	-0.8	0.2	0.2	-1.1	-1.3	-1.2	-0.7
Illnesses of father: High blood pressure	1.2	1.5	2.7	1.4	-1.2	-1.6	0.7	-1.5	-1.2	0.5
Alcohol drinker status: Never	1.2	1.4	3.2	1.2	-1.8	-0.0	-1.2	1.4	1.3	0.6
Ever smoked	0.7	1.3	2.8	-0.4	1.3	-1.7	-0.8	0.3	1.5	-1.2
Basal metabolic rate	0.4	2.5	6.5	-0.9	1.9	-0.9	0.9	-2.2	-2.5	0.1
Leg fat percentage (left)	1.1	3.9	9.0	1.1	-1.1	-2.9	0.3	-3.0	-2.7	-0.7
Arm fat-free mass (left)	0.5	2.6	6.9	-0.6	1.6	-1.2	1.1	-2.4	-2.6	0.4
Number of operations (self-reported)	0.8	1.2	3.2	-0.7	0.4	-1.5	0.4	1.3	1.8	-0.8
Average weekly beer plus cider intake	1.1	1.5	4.4	0.2	1.0	-0.7	-0.4	-2.1	-2.0	0.7
Irritability	0.8	1.3	2.7	1.2	1.3	0.9	1.0	1.2	0.3	1.6
Risk taking	0.5	0.7	3.8	-0.8	-0.5	0.5	1.9	0.2	-0.0	0.1
Ever had prostate specific antigen (PSA) test	1.3	1.5	3.6	-0.4	1.4	-1.3	0.6	1.9	1.7	-0.4
Fractured/broken bones in last 5 years	0.3	0.4	1.4	-0.4	-0.8	-1.2	-0.9	-0.0	-0.2	0.2
Age started oral contraceptive pill	0.8	1.0	3.4	1.9	-1.5	0.1	-0.8	-0.4	-0.3	-0.2
Diastolic blood pressure, automated reading	0.5	1.7	3.9	-0.9	-1.3	2.0	1.3	0.1	-1.5	1.1
Ever depressed for a whole week	0.5	0.7	1.7	-0.4	-1.0	-0.1	-1.3	0.6	0.6	1.1
Unable to work because of sickness or disability	0.6	0.8	3.0	-1.1	0.2	0.8	-1.7	-0.3	0.5	0.6
Commuting to job workplace: Cycle	0.5	0.6	1.4	0.9	1.2	-0.1	1.1	-0.1	-0.5	0.7
Myopia	1.2	1.8	5.2	2.3	-1.4	-1.1	-0.1	-0.5	-0.9	1.8
Vascular/heart problems diagnosed by doctor	1.2	3.2	11.7	1.6	-1.5	0.1	-3.4	-1.7	-1.6	-0.6
Cholesterol lowering medication	0.4	0.6	1.9	-1.0	-0.7	0.5	-0.3	-0.3	0.5	-1.4
Medication: Omeprazole (e.g. Zanprol)	1.7	2.0	3.3	1.5	-0.8	-1.7	-1.6	-0.7	-1.5	1.8
Pain experienced in last month	0.3	0.4	1.5	-0.1	0.6	-1.0	1.2	-0.0	0.2	0.4
Supplements: Calcium	1.4	1.5	3.0	-1.4	1.7	0.5	1.5	0.6	0.2	-1.6
Basal cell carcinoma (self-reported)	2.8	3.3	9.9	-1.4	3.1	1.5	1.7	2.1	1.2	0.8
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.6	-0.0	-0.1	1.3	-0.2	0.4	0.6	0.8
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	3.5	-0.9	0.4	0.8	0.5	-0.7	-0.7	-1.9
Heart disease (siblings)	0.5	0.6	2.8	0.5	-0.1	0.3	1.7	0.6	0.3	0.6
Alcohol drinker status: Previous	0.2	0.2	0.5	0.7	0.2	-0.3	-0.7	-0.2	0.0	-0.3
Pack years of smoking	0.8	1.1	2.2	1.1	-1.1	-1.3	-0.9	-0.8	-1.5	-0.2
Impedance of whole body	0.6	2.9	5.8	-0.9	1.6	2.1	-0.6	2.4	2.4	0.9
Leg fat mass (left)	0.9	3.5	8.3	0.3	0.3	-2.7	1.0	-2.9	-2.7	-0.6
Arm predicted mass (left)	0.5	2.7	8.2	-0.7	1.4	-1.0	0.7	-2.6	-2.9	0.3