Hub : Genes

FAM82A1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Breast Invasive Carcinoma 0.131 0.0337 0.0e+00 0.094 0.089 0.100 NA 0.103 1.5e-18 9.8e-18 8.2e-20 NA 2.5e-20
2 TCGA Head and Neck Squamous Cell Carcinoma 0.046 0.0202 6.2e-04 0.027 0.039 0.036 NA 0.040 4.7e-04 2.8e-05 6.0e-05 NA 2.2e-05
3 TCGA Brain Lower Grade Glioma 0.113 0.0374 2.1e-07 0.040 0.059 0.041 NA 0.053 2.2e-05 2.9e-07 1.7e-05 NA 1.0e-06
4 TCGA Lung Squamous Cell Carcinoma 0.072 0.0283 7.6e-05 0.015 0.026 0.026 NA 0.017 6.4e-03 5.7e-04 5.1e-04 NA 3.9e-03
5 TCGA Ovarian Serous Cystadenocarcinoma 0.062 0.0300 4.6e-03 0.022 0.040 0.025 NA 0.020 1.1e-02 1.0e-03 7.4e-03 NA 1.6e-02
6 TCGA Prostate Adenocarcinoma 0.120 0.0368 4.7e-10 0.073 0.106 0.100 NA 0.099 4.3e-08 3.4e-11 1.4e-10 NA 1.6e-10
7 TCGA Stomach Adenocarcinoma 0.055 0.0280 3.4e-03 0.025 0.030 0.019 NA 0.019 5.9e-03 3.0e-03 1.4e-02 NA 1.4e-02
8 TCGA Thyroid Carcinoma 0.060 0.0260 2.4e-03 0.022 0.019 0.011 NA 0.017 3.1e-03 4.9e-03 2.5e-02 NA 7.9e-03
9 TCGA Uterine Corpus Endometrial Carcinoma 0.501 0.1680 1.7e-03 0.061 0.102 0.124 NA 0.133 8.8e-03 8.8e-04 2.6e-04 NA 1.6e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 0.6 0.9 2.9 -0.2 0.1 -1.5 1.7 0.5 -0.5 1.2 -0.8 0.5
Bipolar Disorder or Schizophrenia 1.2 2.9 6.9 -1.6 -1.0 -2.6 1.0 -1.5 -2.1 0.1 -2.4 -1.6
Depressed Affect (Nagel 2018) 0.1 0.2 0.5 0.1 0.5 -0.2 -0.4 0.2 -0.4 0.7 -0.5 -0.3
Depression (Nagel 2018) 0.2 0.3 0.6 -0.2 0.3 -0.7 -0.4 -0.3 -0.8 0.2 -0.6 -0.7
Intelligence (Savage-Jansen 2018) 0.4 1.2 2.3 -1.4 -1.0 -0.9 -1.0 -0.8 -1.5 -1.3 -1.2 -0.1
Neuroticism (Nagel 2018) 0.2 0.4 1.3 0.9 0.5 0.4 0.2 1.1 0.0 0.8 0.2 0.3
Schizophrenia (2018) 1.8 3.7 6.3 -1.8 -1.3 -2.2 -0.1 -2.4 -2.3 -0.8 -2.4 -2.5
Schizophrenia vs Biploar Disorder 0.7 1.0 2.5 -0.5 -0.4 -0.3 -1.1 -1.6 -0.5 -1.2 -1.0 -1.4
Worry (Nagel 2018) 0.2 0.5 1.8 -0.3 -1.3 -0.2 0.0 -0.4 -1.0 -0.4 -0.9 -0.6
Alzheimer’s Disease (in mother) 1.2 1.4 2.9 1.6 1.6 0.6 0.3 1.0 1.4 1.7 0.7 0.5
Alzheimer’s Disease (in father) 0.3 0.3 1.0 0.2 0.9 -0.1 0.3 0.6 -0.1 0.5 0.2 1.0
Alzheimer’s Disease (including proxy) 0.8 1.2 3.1 1.1 1.8 0.7 0.0 1.1 1.1 1.7 0.6 0.5
Crohns Disease (2017) 1.0 2.2 7.6 1.0 0.7 0.4 2.8 1.3 1.3 -0.4 1.3 2.3
Irritable Bowel Disease (IBD) 1.7 4.1 11.8 1.9 1.5 0.8 3.4 1.7 2.0 -0.3 2.2 2.6
Ulcerative Colitis (UC) 1.5 2.9 4.9 2.1 1.9 1.0 2.2 1.4 2.0 0.5 1.9 1.5
Major Depression (MDD) 2.1 2.6 9.9 1.2 1.0 1.6 -1.3 1.4 2.0 3.1 1.0 -0.2
Reaction Time 0.9 1.6 2.7 1.1 1.5 0.6 0.0 1.6 1.3 1.6 1.5 1.2
Verbal and Numeric Reasoning (VNR) 0.4 0.9 2.1 -1.1 -0.6 -1.3 0.5 -0.2 -1.4 -1.4 -0.7 0.4
Breast Cancer 0.1 0.3 1.2 -0.3 -0.4 -0.2 0.7 -0.6 -0.5 -1.1 -0.5 0.2
Ovarian Cancer 0.4 0.6 3.0 0.7 0.7 -0.0 0.5 0.4 0.7 1.7 -0.5 -0.3
Prostate Cancer 0.3 0.4 2.2 0.2 0.3 -0.3 -0.4 0.0 0.1 1.5 -0.8 -0.3
Age at First Birth 2.6 3.8 6.5 1.9 1.9 2.5 -0.5 2.1 2.5 1.5 2.5 1.0
Bipolar Disorder (2011) 0.6 0.6 1.3 0.9 0.8 -0.3 1.1 0.8 0.7 0.6 0.3 0.9
Body Mass Index (BMI) (2010) 0.5 0.7 1.5 1.2 0.6 1.0 -0.3 0.9 1.0 0.7 0.8 0.3
Coronary Artery Disease (CAD) 0.7 0.8 3.1 0.5 0.9 1.0 0.2 0.8 1.1 1.8 0.6 -0.3
Crohns Disease (2012) 1.2 1.9 4.7 1.3 1.0 0.4 2.2 1.3 1.3 -0.4 1.4 2.0
Mean Putamen Volume 0.4 0.4 1.5 -0.2 0.1 0.9 -0.8 0.5 0.6 1.2 0.5 -0.1
Fasting Glucose 0.2 0.2 0.8 -0.0 -0.9 -0.1 0.7 0.0 -0.2 -0.2 -0.3 0.6
HbA1C 2.1 2.3 5.4 -2.2 -2.3 0.4 -0.8 -1.8 -1.3 -1.6 -1.1 -1.0
HDL Cholesterol 0.6 1.0 2.0 -1.2 -0.9 -1.4 0.6 -0.5 -1.4 -1.3 -0.3 0.1
LDL Cholesterol 0.7 1.1 3.7 0.6 0.8 1.9 -0.7 0.8 1.5 0.6 1.3 -0.0
Lupus 0.4 0.6 3.1 -0.1 -0.7 0.4 0.6 0.6 0.2 -0.4 0.8 1.8
Neuroticism (2016) 0.2 0.3 1.3 0.2 -0.4 0.3 1.1 0.3 0.2 0.6 -0.3 1.0
Primary Biliary Cirrhosis 0.3 0.5 1.5 -1.0 -1.2 0.2 -0.6 -0.3 -0.2 -0.7 0.7 -0.4
Rheumatoid Arthritis 0.3 0.4 2.2 0.7 0.2 0.4 0.1 0.5 0.2 1.5 -0.3 0.1
Schizophrenia (2014) 2.1 4.6 8.4 -1.9 -1.1 -2.5 -0.4 -2.6 -2.5 -1.0 -2.9 -2.8
Triglycerides 1.1 1.9 3.7 1.5 1.2 1.7 0.1 1.2 1.9 1.1 1.2 1.4
Type 2 Diabetes (T2D) (2012) 0.5 0.5 1.8 0.1 -0.8 1.3 -1.3 0.1 0.6 -0.1 0.5 -0.3
Ulcerative Colitis 1.2 1.8 3.8 1.9 1.5 0.8 1.6 1.0 1.6 0.3 1.6 0.7
Blood Eosinophil Count 1.1 8.1 25.8 -1.9 -3.6 -1.9 0.0 -3.8 -2.9 -5.1 -1.7 -1.1
Blood Platelet Count 0.1 1.1 3.0 0.9 1.1 -1.1 0.9 -0.5 0.2 1.4 -1.7 -0.5
Blood Red Count 0.0 0.4 1.3 0.3 0.3 0.1 1.1 1.0 0.2 0.1 0.9 0.5
Blood White Count 0.4 2.7 5.1 -1.8 -1.7 -0.9 -1.5 -2.2 -1.6 -2.0 -1.5 -1.3
Heel T-Score 0.1 1.1 2.3 1.4 1.5 0.8 1.0 1.3 1.1 -0.1 1.2 0.4
BMI 0.3 1.9 5.4 -0.7 -0.3 -1.7 2.0 -0.6 -1.3 -2.3 0.1 1.6
Height 0.6 11.8 31.6 3.4 4.1 -0.9 1.9 4.8 2.2 5.6 1.8 3.4
Waist Hip Ratio (WHR) 0.2 1.1 3.2 1.2 1.8 -0.2 -0.3 1.0 1.0 1.6 0.4 -0.3
Systolic Blood Pressure 0.2 1.0 2.5 0.9 1.4 0.2 -0.2 1.1 1.0 1.6 -0.4 1.0
Smoking Status 0.1 0.4 2.1 0.3 1.5 -0.3 -0.2 0.5 -0.0 0.3 0.5 -0.4
Allergy or Eczema 1.3 3.3 6.4 2.5 1.6 1.9 1.8 1.6 2.2 1.0 2.0 1.2
Cardiovascular Disease 1.7 5.7 14.1 2.9 3.8 -0.4 2.2 2.4 1.9 3.3 0.5 1.9
Hypothyroidism (self reported) 0.2 0.6 2.6 -0.8 -1.6 0.5 -0.4 -0.8 -0.3 -0.4 -0.0 -0.7
Respiratory disease 2.6 5.8 16.1 -2.8 -4.0 -0.3 -1.1 -3.2 -1.8 -3.3 -1.2 -1.1
Type 2 Diabetes (T2D) (2018) 0.9 1.7 3.4 0.9 1.8 0.2 0.0 1.8 0.9 1.3 1.4 1.8
Lung FEV1/FVC ratio 1.5 7.6 16.9 2.8 3.4 1.4 0.3 4.1 2.2 3.2 2.4 3.0
Lung FVC 0.6 3.1 11.2 -1.1 -1.8 -1.4 0.4 -2.1 -1.9 -3.3 -0.8 -1.1
Neuroticism 0.1 0.2 0.6 0.4 0.1 -0.5 0.0 0.3 -0.5 0.7 -0.7 -0.4
Chronotype (morning person) 0.3 0.7 2.5 0.6 0.2 0.6 1.4 0.5 1.0 0.3 0.5 1.6
Hair Pigment 0.1 2.9 7.0 1.4 1.0 2.6 -0.4 1.6 2.0 0.6 2.4 1.8
Tanning 5.2 63.3 132.2 -8.7 -11.5 -2.2 -4.8 -10.7 -6.7 -10.6 -5.8 -5.3
Hand grip strength (left) 0.8 2.0 4.3 -1.3 -1.3 -2.1 0.9 -1.0 -1.8 -1.9 -1.2 -0.3
Number of treatments/medications taken 0.7 1.2 4.1 1.5 1.6 0.3 -0.6 0.5 0.9 2.0 -0.4 -0.5
Average weekly spirits intake 0.7 0.9 3.7 -1.2 -0.5 -1.0 0.3 -0.7 -0.9 -1.9 -0.0 -0.0
Sensitivity / hurt feelings 0.4 0.7 2.2 0.4 0.5 -0.1 1.0 1.3 0.2 0.9 0.6 1.5
Frequency of depressed mood in last 2 weeks 0.5 0.7 1.3 -0.4 0.1 -0.7 -0.8 -0.6 -0.8 1.0 -1.1 -1.1
Hearing difficulty/problems: Yes 1.2 1.9 2.9 -1.3 -1.0 -1.5 0.4 -1.6 -1.6 -1.5 -1.7 -1.2
Relative age of first facial hair 1.4 2.9 4.5 -1.8 -1.3 -1.1 -1.9 -1.9 -1.8 -1.0 -2.1 -2.1
Other serious medical condition/disability diagnosed by doctor 0.8 1.0 1.6 1.0 0.7 1.1 0.7 1.1 1.3 1.2 1.1 0.4
Ever used hormone-replacement therapy (HRT) 3.5 4.5 8.9 2.5 1.2 3.0 -0.2 2.2 2.5 1.4 3.0 1.3
Ever had hysterectomy (womb removed) 2.3 2.6 4.2 1.9 1.3 2.0 1.3 1.5 2.1 0.4 1.9 1.4
Systolic blood pressure, automated reading 0.2 0.7 3.4 0.4 1.0 -0.7 0.4 0.7 0.2 0.8 -0.4 1.8
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 1.1 0.7 0.9 -0.0 0.4 -0.0 0.0 1.0 -0.4 -0.6
Angina 0.1 0.1 0.7 0.3 -0.1 -0.0 0.1 -0.4 0.1 -0.8 0.4 -0.2
Medication for hormone replacement therapy 0.6 0.7 3.3 0.6 -0.3 1.8 -0.6 0.3 0.7 -0.3 1.1 -0.1
Vitamin and mineral supplements 0.6 0.8 1.3 -1.2 -0.4 -1.0 -0.1 -0.9 -1.1 -1.1 -1.1 -0.3
Supplements: Zinc 0.8 0.9 2.2 -1.1 -0.9 -1.1 -1.5 -1.0 -0.6 -0.8 -0.4 -0.4
Medication: Co-codamol 0.3 0.3 1.1 0.7 0.5 0.1 0.2 0.1 0.5 1.1 -0.4 0.6
Medication: Metformin 0.5 0.7 2.6 -1.0 0.1 -0.2 -1.6 -0.0 -0.6 0.8 -0.7 -0.9
Diabetes (father) 3.8 4.7 7.4 2.2 2.5 2.6 0.2 2.7 2.6 1.4 2.7 0.9
Diabetes (mother) 0.8 1.0 3.3 -0.8 -0.6 -1.4 0.3 -1.0 -1.2 -1.8 -0.6 -0.2
Severe depression (siblings) 1.4 1.6 3.5 -0.8 -0.3 -1.1 -0.7 -1.6 -1.5 -0.9 -1.6 -1.9
Pack years adult smoking proportion 0.1 0.2 0.9 -0.3 0.1 -1.0 0.3 0.2 -0.4 0.1 -0.3 0.6
Impedance of leg (right) 0.1 0.4 1.4 0.5 -0.2 1.2 -0.8 -0.0 0.7 0.2 0.9 -0.3
Leg fat-free mass (left) 0.3 1.4 3.1 0.5 1.6 -1.6 1.8 1.2 -0.1 1.0 0.1 1.3
Trunk fat percentage 0.2 0.8 3.9 0.2 0.4 -0.1 0.5 0.9 0.5 0.1 1.4 2.0
Hand grip strength (right) 0.4 1.0 3.0 -0.9 -0.8 -1.7 1.2 -0.3 -1.2 -0.6 -1.1 0.1
Townsend deprivation index at recruitment 1.2 1.7 4.2 -1.2 -1.4 0.1 -1.5 -1.4 -1.1 -1.2 -0.7 -2.1
Current tobacco smoking 0.7 1.1 4.2 -0.5 1.1 -2.1 -0.0 -0.5 -0.9 0.6 -1.0 -1.4
Average weekly fortified wine intake 0.6 0.7 3.0 0.6 -0.4 -0.3 1.5 -0.2 -0.3 -1.7 0.5 0.4
Maternal smoking around birth 0.9 1.3 3.5 -0.4 0.2 -1.0 -0.8 -1.1 -1.3 -0.0 -1.8 -1.9
Fed-up feelings 0.4 0.8 2.2 -0.0 1.4 -0.7 -0.3 -0.1 -0.4 1.4 -1.5 -0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 1.5 2.1 3.8 -1.4 -0.9 -1.1 -1.2 -1.9 -1.6 -0.2 -1.9 -1.8
Relative age voice broke 0.6 0.9 3.1 0.4 0.3 1.6 -1.7 0.2 0.9 0.7 0.5 -1.0
Taking other prescription medications 0.3 0.4 1.1 -0.5 -1.1 -0.2 -0.4 -0.9 -0.7 -0.4 -0.6 -0.4
Age when periods started (menarche) 0.7 1.6 4.5 -0.9 -1.6 -0.1 -0.9 -1.6 -0.9 -0.4 -1.3 -2.1
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 2.6 -0.2 -1.0 -0.3 0.7 -0.1 -0.7 -1.6 0.7 0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 2.7 -0.4 0.3 -0.8 -0.0 -1.0 -0.8 -1.6 -0.8 -0.6
Tinnitus: Yes, but not now, but have in the past 1.7 1.8 3.0 -1.6 -1.5 -0.3 -1.7 -1.7 -1.2 -1.2 -1.0 -1.2
Qualifications: CSEs or equivalent 0.2 0.3 1.0 0.6 0.2 -0.1 1.0 -0.1 0.4 -0.8 0.4 0.5
Serious illness, injury or assault to yourself 0.2 0.3 1.1 0.1 0.4 -0.3 1.1 0.0 0.2 -0.5 0.4 0.9
High blood pressure 0.9 2.5 7.9 1.9 2.8 -0.7 0.6 1.0 0.7 2.7 -1.0 0.1
Hayfever, allergic rhinitis or eczema 1.1 2.3 4.8 2.2 1.6 1.7 0.6 1.3 2.0 1.4 1.5 0.6
Multivitamins +/- minerals 0.6 0.7 2.1 1.0 0.5 1.2 -0.3 0.7 1.0 1.5 0.5 -0.2
Stomach or abdominal pain in last month 0.3 0.3 1.3 0.7 -0.2 1.2 0.3 -0.3 0.4 -0.4 0.3 -0.7
Supplements: Glucosamine 0.1 0.2 0.4 0.2 -0.5 0.6 -0.5 0.3 0.4 0.5 0.1 -0.3
Diverticular disease/diverticulitis (self-reported) 0.8 0.9 2.2 0.9 0.5 1.5 0.7 0.7 1.3 -0.0 1.5 -0.3
Medication: Atenolol 1.1 1.4 4.2 0.6 1.8 0.2 -0.6 0.1 0.8 2.1 -1.1 -1.6
Medication: Levothyroxine sodium 0.3 0.6 1.6 -0.3 -0.9 1.3 -0.8 -0.2 0.5 0.3 1.2 0.1
Sitting height 0.8 5.5 10.2 2.7 2.5 0.1 2.5 3.2 1.9 2.6 1.9 2.2
Chronic bronchitis/emphysema (father) 1.8 2.1 4.0 -1.6 -1.7 -0.5 -0.4 -2.0 -1.6 -1.6 -1.6 -1.1
High blood pressure (mother) 0.2 0.3 0.7 -0.4 0.3 -0.5 0.1 -0.4 -0.4 0.8 -0.8 -0.4
Body mass index (BMI) 0.2 0.8 2.1 -0.7 0.1 -1.4 0.9 -0.4 -0.9 -1.3 -0.1 1.0
Impedance of leg (left) 0.1 0.6 1.8 0.7 -0.0 1.4 -0.6 0.5 0.9 0.4 1.2 0.3
Leg predicted mass (left) 0.3 1.5 3.4 0.6 1.7 -1.5 1.8 1.3 0.0 1.1 0.2 1.3
Trunk fat mass 0.3 1.2 4.7 0.5 1.0 -0.4 1.0 1.3 0.6 0.3 1.4 2.2
Waist circumference 0.2 0.7 1.8 0.1 1.1 -1.3 0.8 0.5 -0.2 -0.1 0.6 1.3
Number of incorrect matches in round 0.6 1.0 2.9 0.4 -0.1 1.4 -1.7 0.5 0.8 1.6 0.7 -0.4
Past tobacco smoking 0.6 1.2 3.0 -1.0 -1.1 -1.7 0.6 -1.0 -1.2 0.0 -1.7 -0.3
Alcohol usually taken with meals 0.8 1.2 5.7 0.7 -0.8 2.4 -0.7 0.4 1.4 1.3 0.1 -0.4
Nervous feelings 0.0 0.1 0.3 -0.0 -0.4 0.5 -0.3 -0.1 -0.3 -0.1 -0.1 -0.0
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.3 4.0 -0.1 -0.0 -0.6 -1.4 -1.1 -0.9 1.1 -1.6 -2.0
Hearing difficulty/problems with background noise 0.6 1.0 2.6 -1.1 -1.1 -1.1 0.4 -0.9 -1.1 -0.5 -1.6 -0.1
Hair/balding pattern: Pattern 2 0.6 0.8 3.3 0.5 1.4 -0.3 0.7 0.6 0.4 1.8 0.1 0.0
Had menopause 1.3 1.6 4.2 0.6 -0.7 2.0 -0.0 0.9 1.1 -0.9 1.7 1.9
Had other major operations 0.8 0.9 2.3 -0.9 -1.5 1.2 -0.7 -1.0 0.1 -1.4 0.2 -0.6
Forced vital capacity (FVC) 0.2 0.7 2.3 0.2 -0.3 -1.0 1.5 -0.5 -0.6 -1.3 0.3 -0.5
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 1.6 0.4 1.1 0.5 -1.2 -0.1 0.2 -0.2 -0.0 -0.7
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.7 0.8 1.3 0.4 -0.1 0.7 0.8 1.2 0.5 -0.6
Qualifications: None of the above 0.1 0.3 0.9 -0.4 -0.2 0.5 -0.5 0.5 -0.0 -0.0 0.8 1.0
Financial difficulties in last 2 years 0.2 0.2 0.6 0.1 0.2 -0.5 -0.3 -0.2 -0.1 0.8 -0.7 -0.6
Mouth/teeth dental problems 0.5 0.7 1.6 -0.5 0.5 -1.1 -0.4 -1.0 -0.8 -0.7 -1.3 -0.8
Heart attack 0.8 1.0 2.5 1.2 1.4 0.7 -0.7 0.8 1.1 1.6 0.2 -0.4
Allergy 0.2 0.6 1.4 -1.2 -0.4 -1.0 -0.8 0.0 -0.9 0.4 -0.8 -0.4
Pain all over the body in last month 0.4 0.4 2.2 0.2 -0.1 -0.8 1.5 -0.3 -0.0 -0.7 0.0 0.2
Diabetes (self-reported) 0.3 0.5 1.8 0.5 0.8 0.2 -0.7 0.8 0.3 1.3 -0.0 0.8
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 1.2 0.4 -0.2 0.4 -0.3 -1.1 0.1 -0.6 -0.4 -0.5
Medication: Ramipril 2.1 2.7 5.6 2.1 2.4 1.1 0.8 1.6 2.1 1.5 1.2 1.4
Medication: Simvastatin 1.1 1.6 6.1 -1.3 -0.2 -2.5 0.6 -0.7 -1.7 0.0 -1.6 -0.3
Fluid intelligence score 0.4 0.9 1.4 -0.8 -1.0 -1.0 1.2 -0.3 -1.1 -1.2 -1.0 0.4
Illnesses of siblings 3.2 4.4 6.9 -2.6 -2.4 -1.8 -0.7 -2.3 -2.6 -1.3 -2.5 -1.9
Neuroticism score 0.2 0.3 1.4 0.7 0.7 0.3 0.3 0.7 0.1 1.2 -0.1 0.2
Weight 0.3 1.5 4.2 0.5 1.4 -1.3 1.7 1.3 0.1 0.6 0.8 2.0
Impedance of arm (right) 0.9 4.1 8.5 1.4 0.3 2.9 -1.4 1.8 2.8 2.6 2.3 1.0
Arm fat percentage (right) 0.1 0.5 3.1 -0.0 0.4 -0.2 0.3 0.5 0.4 -0.2 1.0 1.8
Trunk fat-free mass 0.2 1.4 3.2 0.6 1.6 -1.8 1.8 1.0 -0.4 0.7 -0.2 1.1
Hip circumference 0.2 0.9 3.6 0.3 0.8 -0.8 1.1 1.0 0.1 0.4 1.0 1.9
Time employed in main current job 1.1 1.3 2.4 1.3 1.2 1.2 -0.5 1.6 1.0 0.9 1.3 1.1
Alcohol intake versus 10 years previously 2.8 4.2 9.1 2.3 1.6 0.8 2.3 2.7 1.3 1.1 2.3 3.0
Father’s age at death 0.0 0.0 0.2 -0.1 -0.3 -0.0 -0.1 0.3 -0.1 -0.1 0.0 0.5
Worrier / anxious feelings 0.3 0.6 1.2 -0.7 -0.9 -0.7 0.4 -0.8 -1.1 -0.5 -0.8 -0.9
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 2.8 0.4 1.5 -0.9 0.5 0.9 -0.2 1.7 -0.4 0.2
Falls in the last year 0.5 0.7 2.9 0.3 0.8 -0.1 -0.8 -0.1 0.6 1.7 -0.9 -0.8
Hair/balding pattern: Pattern 3 0.4 0.5 1.7 0.7 -0.1 1.2 -1.3 0.3 0.8 0.8 -0.1 -0.2
Number of live births 1.2 1.7 3.5 -1.9 -1.4 -1.0 -1.2 -1.3 -1.2 -1.0 -1.2 -1.1
Forced expiratory volume in 1-second (FEV1) 0.1 0.5 2.1 0.8 0.6 -0.7 1.4 0.4 0.0 0.1 0.6 0.1
Pulse rate 1.5 2.5 6.4 -1.2 -0.7 -2.5 0.5 -1.8 -2.1 -1.2 -1.9 -0.8
Happiness 1.9 2.3 8.8 1.7 1.6 1.3 0.1 1.4 1.6 3.0 0.1 -0.6
Noisy workplace 1.5 1.9 3.2 1.8 1.7 0.8 0.2 1.8 1.2 1.4 1.7 1.0
Qualifications: A levels/AS levels or equivalent 0.5 1.1 3.6 -0.4 -1.2 -0.2 1.7 -0.6 -0.8 -1.9 -0.3 0.1
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 2.0 1.1 1.3 1.3 -0.5 0.7 1.4 0.9 1.0 0.1
Mouth/teeth dental problems: Dentures 0.8 1.3 5.5 -0.9 -2.3 0.7 -0.2 -0.7 -0.5 -1.9 0.7 0.3
Asthma 2.5 4.9 12.1 -1.9 -3.2 -0.9 -0.5 -3.0 -2.0 -3.5 -1.6 -1.0
Medication: Ibuprofen (e.g. Nurofen) 1.3 1.7 7.0 0.8 1.1 -1.4 1.8 0.4 0.3 2.6 -0.8 0.5
Medication: Cholesterol lowering 0.4 0.6 1.8 -0.2 0.9 -1.2 0.2 0.7 -0.3 1.3 -0.6 0.2
Depression (self-reported) 0.3 0.4 1.8 0.1 -0.7 0.7 0.1 -0.1 0.2 -0.6 0.5 1.3
Medication: Lansoprazole 0.3 0.4 1.7 -0.4 -0.4 0.6 -1.3 -0.5 0.1 0.3 0.1 -0.7
Prospective memory result 0.7 0.8 2.4 -1.5 -1.4 -0.2 -0.0 -0.8 -0.6 -1.4 0.0 -0.5
Lung cancer (father) 1.2 1.4 5.5 0.0 -0.1 0.3 -2.3 -0.3 0.0 2.2 -0.9 -1.1
Illnesses of mother 0.2 0.2 0.8 -0.5 -0.7 0.2 -0.6 -0.4 -0.3 -0.9 -0.0 -0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.3 0.6 0.7 0.6 -0.8 0.7 0.4 0.0 0.5 0.2 -0.1
Pulse wave Arterial Stiffness index 2.2 2.5 4.3 1.8 2.0 0.8 1.4 2.1 1.3 0.8 1.8 1.7
Impedance of arm (left) 0.5 2.1 5.6 0.6 -0.4 2.1 -1.6 1.0 2.0 2.4 1.2 0.2
Arm fat mass (right) 0.2 0.7 2.4 0.4 1.1 -0.6 0.7 0.8 0.3 0.1 0.9 1.5
Trunk predicted mass 0.2 1.3 3.6 0.6 1.5 -1.7 1.9 1.0 -0.4 0.5 -0.1 1.1
Standing height 0.6 6.4 15.5 2.5 2.9 -0.0 1.6 3.6 2.1 3.9 1.7 2.1
Length of working week for main job 0.7 0.8 1.5 -1.0 -0.3 -1.2 0.4 -0.8 -0.9 -1.0 -0.5 -1.2
Exposure to tobacco smoke at home 2.0 2.3 3.6 -1.9 -1.2 -1.4 -0.9 -1.9 -1.8 -1.1 -1.7 -1.4
Breastfed as a baby 0.3 0.3 1.2 -0.1 0.2 -0.7 -0.0 -0.6 -0.4 0.0 -1.1 -0.8
Tense / ‘highly strung’ 1.3 2.1 8.4 1.8 1.1 1.1 0.8 1.6 1.2 2.9 0.5 0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.1 0.2 0.3 -0.3 0.1 -0.1 -0.4 -0.3 -0.5 0.4 0.4
Hair/balding pattern: Pattern 4 0.1 0.2 0.6 0.3 0.1 0.5 0.1 0.4 0.3 -0.6 0.8 0.1
Birth weight of first child 0.2 0.4 1.2 0.4 0.1 -0.1 1.1 0.5 -0.1 -1.1 0.6 0.6
Peak expiratory flow (PEF) 0.3 0.7 1.8 0.4 1.0 -1.2 1.1 0.7 -0.5 1.4 -0.0 0.3
Pulse wave reflection index 0.5 0.6 1.3 0.6 0.7 0.9 -0.8 1.1 0.8 0.1 1.1 0.5
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.7 -0.1 0.8 -0.7 -0.0 0.1 -0.2 0.5 0.1 -0.6
Loud music exposure frequency 0.9 1.0 2.3 1.1 0.5 1.5 0.1 1.0 1.5 -0.0 1.4 0.6
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 2.5 -0.9 -1.6 0.2 0.4 -1.1 -0.4 -1.1 -0.7 -0.7
Mouth/teeth dental problems: Bleeding gums 0.3 0.3 1.8 -0.2 -0.6 -0.1 -0.1 0.3 0.2 1.4 -0.4 -0.7
Blood clot in the leg (DVT) 2.0 2.6 4.7 1.8 1.6 1.2 1.8 1.6 1.9 0.6 1.5 2.2
Medication: Paracetamol 0.5 0.9 2.3 1.5 1.1 0.6 0.2 0.6 1.1 1.5 -0.1 -0.5
Headache pain in last month 0.7 1.3 5.3 -0.8 -1.1 -0.8 0.2 -1.4 -0.9 0.1 -2.3 -0.9
Medication for cholesterol, blood pressure or diabetes 0.7 1.2 3.3 -0.8 -1.4 1.0 -1.4 -1.2 -0.1 -0.5 -0.3 -1.8
Glaucoma (self-reported) 1.4 1.6 3.2 1.4 1.4 1.0 1.3 1.4 1.1 -0.1 1.8 1.1
Gout (self-reported) 1.8 2.5 7.1 -1.2 -0.8 -2.7 1.5 -1.4 -2.0 -1.7 -1.5 0.2
Hypothyroidism/myxoedema (self-reported) 0.4 0.7 1.7 -0.6 -1.3 1.1 -1.2 -0.8 -0.0 -0.3 0.3 -0.9
Medication: Amlodipine 0.6 0.9 3.8 0.8 2.0 -1.0 0.5 -0.0 -0.0 0.8 -0.5 -1.1
Medication: Ventolin 100micrograms inhaler 2.3 3.0 10.1 -1.1 -1.7 -1.4 0.6 -2.3 -1.8 -3.2 -1.3 -0.5
Birth weight 0.6 1.2 3.4 -0.6 0.5 -1.8 1.1 -0.4 -1.7 -1.1 -0.9 -0.6
Chronic bronchitis/emphysema (mother) 2.9 3.3 6.8 -1.9 -2.4 -0.4 -1.3 -2.6 -1.2 -0.9 -2.0 -2.5
High blood pressure (siblings) 1.0 1.5 4.7 1.8 2.2 -0.0 0.9 1.2 0.9 1.5 0.4 0.4
Forced vital capacity (FVC), Best measure 0.2 0.9 3.3 -0.3 -0.4 -1.8 0.9 -0.7 -1.2 -0.9 -0.6 -0.7
Body fat percentage 0.2 0.6 3.5 -0.2 0.1 -0.4 0.6 0.4 0.1 -0.6 1.1 1.9
Leg fat percentage (right) 0.3 1.2 4.9 -0.5 -0.4 -0.7 1.0 -0.5 -0.6 -2.2 0.8 1.6
Arm fat-free mass (right) 0.3 1.5 4.6 0.5 1.4 -1.9 2.1 1.0 -0.6 0.3 -0.1 1.1
Exposure to tobacco smoke outside home 1.3 1.7 4.2 -1.6 -2.1 -1.3 -0.4 -1.6 -1.3 -0.6 -1.6 0.2
Comparative body size at age 10 1.5 4.2 11.0 -2.2 -2.1 -2.1 0.6 -2.2 -2.2 -3.3 -1.7 -0.7
Number of full brothers 0.6 0.8 2.8 1.7 1.3 0.4 0.5 0.3 0.9 0.6 0.2 -0.9
Worry too long after embarrassment 0.7 1.1 2.4 1.2 1.5 0.7 -0.5 1.2 0.9 1.6 0.8 0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 1.6 2.1 3.8 -1.4 -1.3 -0.9 -1.1 -2.0 -1.8 -1.4 -1.5 -1.6
Wheeze or whistling in the chest in last year 1.4 2.5 5.2 -1.5 -2.0 -0.5 -0.7 -2.3 -1.5 -2.2 -1.2 -1.1
Number of children fathered 0.4 0.5 1.4 -0.1 0.6 -1.2 0.2 -0.3 -0.5 0.7 -1.2 -0.5
Reason for reducing amount of alcohol drunk: Health precaution 1.2 1.5 6.0 0.4 -0.4 -0.1 2.4 -0.1 -0.1 -2.2 1.1 0.9
Age at first live birth 1.8 3.2 6.2 2.5 1.9 1.3 0.9 2.1 2.1 0.8 2.2 1.6
Pulse wave peak to peak time 2.0 2.3 3.8 -1.8 -1.9 -0.9 -1.2 -1.9 -1.3 -0.7 -1.8 -1.6
Health satisfaction 0.4 0.6 1.9 0.9 1.0 0.5 0.2 0.5 0.9 1.4 -0.0 0.1
Shortness of breath walking on level ground 0.2 0.2 0.8 -0.3 0.4 -0.5 -0.4 0.3 -0.3 0.9 0.3 0.6
Qualifications: College or University degree 0.3 1.1 1.5 -1.2 -1.0 -1.0 0.4 -1.1 -1.2 -1.2 -0.8 -1.2
Eye problems/disorders: None of the above 2.1 2.4 7.4 -1.7 -1.6 -1.3 0.1 -1.7 -1.7 -2.7 -1.2 -0.0
Mouth/teeth dental problems: Loose teeth 1.1 1.4 3.1 -0.9 -1.8 0.6 -1.0 -1.6 -0.3 -1.3 -0.3 -1.6
Emphysema/chronic bronchitis 0.2 0.2 0.4 -0.5 -0.6 0.1 -0.6 -0.6 0.3 0.4 -0.3 0.1
Medication for pain relief, constipation, heartburn 0.3 0.5 2.6 -0.8 -0.7 0.1 -0.0 -0.4 -0.2 -1.6 0.3 0.3
Neck or shoulder pain in last month 0.1 0.2 0.5 0.6 -0.1 0.7 0.4 0.3 0.2 0.7 -0.2 -0.2
Medication: Blood pressure 0.4 0.6 1.5 0.7 1.2 -1.0 0.9 0.3 0.0 0.2 -0.4 1.2
Angina (self-reported) 0.1 0.1 0.3 0.5 0.0 0.1 0.1 -0.2 0.3 -0.4 0.4 -0.1
Migraine (self-reported) 0.5 0.6 1.7 -0.3 -0.6 0.4 -0.6 -1.3 0.0 -0.7 -1.0 -1.3
Medication: Ibuprofen 2.6 3.2 7.7 1.8 2.2 -1.1 2.8 1.4 1.0 2.5 0.2 1.5
Medication: Allopurinol 2.2 2.9 6.5 -1.5 -1.3 -2.5 1.1 -1.6 -2.2 -1.4 -2.3 -0.3
Medication: Omeprazole 0.7 0.8 2.3 -1.0 -0.4 -1.5 -0.8 -0.8 -1.1 -0.5 -0.7 -0.8
Medication: Seretide 50 evohaler 1.2 1.4 2.9 -0.3 -0.6 -1.7 1.2 -1.5 -1.2 -1.2 -1.6 -0.5
Mean time to correctly identify matches 0.7 1.4 2.6 0.6 0.9 1.3 -1.6 1.1 1.2 1.4 1.4 0.3
Heart disease (mother) 0.7 0.8 1.7 1.2 1.1 -0.2 1.3 1.1 0.7 1.0 0.4 0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.9 3.1 0.5 0.8 1.3 -0.1 0.5 1.1 1.8 0.3 -0.7
Whole body fat mass 0.2 1.0 4.0 0.4 1.0 -0.5 1.0 1.1 0.4 0.2 1.2 2.0
Leg fat mass (right) 0.2 0.8 2.6 -0.1 0.5 -1.1 1.2 0.2 -0.5 -1.1 0.8 1.6
Arm predicted mass (right) 0.4 1.8 5.2 0.5 1.8 -2.2 2.3 1.1 -0.7 0.3 -0.1 1.1
Pulse rate, automated reading 0.6 1.8 4.9 -0.4 0.1 -2.0 2.0 -1.0 -1.2 -2.2 -0.7 0.4
Alcohol intake frequency. 0.6 1.3 2.4 1.1 0.3 1.5 -1.0 1.3 1.3 0.8 1.6 0.9
Comparative height size at age 10 0.9 5.1 9.2 2.1 2.0 0.5 1.4 3.0 2.4 2.9 2.0 2.8
Number of full sisters 0.1 0.1 0.6 0.1 -0.2 -0.0 -0.1 0.1 0.1 -0.5 0.8 0.2
Suffer from ‘nerves’ 0.4 0.6 1.7 1.2 0.4 0.9 -0.5 0.6 0.4 1.3 -0.1 -0.0
Overall health rating 1.1 2.4 9.0 -1.0 0.1 -3.0 0.4 -1.2 -1.7 0.5 -2.4 -1.0
Chest pain or discomfort 0.8 1.1 1.9 -0.8 -0.7 -1.3 0.9 -1.2 -1.2 -1.4 -1.0 -0.5
Had major operations 0.5 0.5 2.0 0.1 0.3 0.1 0.3 0.7 0.2 -1.0 1.0 1.4
Age at last live birth 0.2 0.3 0.8 0.4 0.6 -0.7 -0.5 -0.2 -0.2 -0.5 -0.2 -0.9
Family relationship satisfaction 0.4 0.5 1.5 0.3 0.1 0.8 -0.8 0.3 0.6 1.0 0.1 -1.2
Leg pain on walking 0.2 0.2 1.1 0.4 0.6 -0.1 1.1 0.2 0.3 0.5 -0.2 -0.3
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 1.8 0.7 0.7 -1.4 -0.0 -0.0 -0.4 1.0 -1.3 -0.3
Commuting to job workplace: Car/motor vehicle 0.5 0.5 1.0 -1.0 -1.0 -0.8 0.0 -0.8 -0.8 -0.6 -0.6 0.3
Illness, injury, bereavement, stress in last 2 years 1.8 2.2 3.5 -1.8 -1.6 -1.7 0.5 -1.5 -1.9 -1.7 -1.5 -0.6
Medication: Aspirin 0.1 0.2 0.6 0.1 0.8 -0.5 0.2 0.2 -0.2 0.7 -0.4 -0.1
Supplements: Vitamin C 0.3 0.4 1.9 -0.3 -0.4 0.8 -0.2 0.5 0.6 0.0 1.4 0.3
Knee pain experienced in last month 0.4 0.6 1.8 0.1 -0.5 1.4 -1.3 -0.4 0.8 0.2 0.1 -0.7
Hypertension (Self-reported) 1.3 3.6 11.5 2.4 3.4 -0.7 1.2 1.6 1.1 2.8 -0.7 0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.2 1.4 4.0 -0.7 0.1 -0.7 -1.9 -0.6 -0.8 1.4 -1.2 -2.0
Illnesses of father: Heart disease 3.5 4.8 8.3 2.1 1.2 2.7 1.4 2.2 2.7 0.6 2.9 2.8
Illnesses of siblings: Diabetes 1.8 2.2 5.8 0.8 0.5 2.4 -0.9 1.3 1.5 -0.6 2.3 1.6
Smoking status: Previous 1.2 1.8 7.0 1.1 0.7 2.7 -0.5 1.1 1.6 0.0 1.8 0.5
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.3 3.4 1.1 1.1 -0.2 1.3 1.3 0.8 1.9 0.6 1.1
Whole body fat-free mass 0.3 1.7 4.1 0.6 1.8 -1.9 2.0 1.2 -0.3 0.9 -0.1 1.2
Leg fat-free mass (right) 0.3 1.8 3.8 0.5 1.7 -1.8 1.9 1.4 -0.1 1.3 0.1 1.4
Arm fat percentage (left) 0.1 0.4 2.2 -0.3 0.1 -0.6 0.4 0.2 0.0 -0.3 0.5 1.5
Average weekly red wine intake 0.3 0.5 2.1 0.1 0.1 0.1 -0.6 -0.6 -0.1 0.3 -1.5 -1.1
Handedness (chirality/laterality): Left-handed 0.6 0.7 2.0 -0.9 -0.8 -0.8 -0.2 -0.8 -1.0 -1.4 -0.0 -0.4
Mood swings 0.4 0.7 3.8 0.7 0.7 0.2 0.4 0.8 0.4 1.9 -0.3 0.1
Loneliness, isolation 0.9 1.2 2.6 -0.7 -0.1 -1.3 -1.1 -1.0 -1.1 0.8 -1.6 -1.3
Long-standing illness, disability or infirmity 0.2 0.3 0.9 0.3 1.0 -0.4 0.7 -0.0 0.1 0.4 -0.2 -0.7
Ever had bowel cancer screening 0.6 0.7 2.1 0.1 0.2 1.3 -1.4 0.6 0.7 1.0 0.8 0.2
Diabetes diagnosed by doctor 0.3 0.4 1.5 0.1 0.9 0.1 -0.9 0.5 0.2 1.2 -0.0 0.4
Ever had stillbirth, spontaneous miscarriage or termination 2.3 2.4 6.0 -1.6 -0.7 -2.5 -0.4 -1.5 -2.0 -0.2 -2.1 -1.3
Friendships satisfaction 0.4 0.5 2.2 0.7 0.1 1.5 -0.1 0.1 0.8 0.3 0.2 -1.0
Qualifications: nursing, teaching 0.5 0.8 2.8 -0.5 -0.3 0.2 -1.2 -1.3 -0.1 -0.7 -0.6 -1.7
Commuting to job workplace: Walk 0.6 0.6 1.2 0.5 0.2 1.0 0.9 0.6 0.7 -0.7 1.1 1.1
Eye problems/disorders: Cataract 2.2 2.6 5.2 1.6 1.0 2.3 -0.7 1.4 2.1 2.0 1.7 0.2
Mouth/teeth dental problems: Mouth ulcers 0.7 1.2 3.4 1.1 1.6 0.1 0.9 1.1 0.9 1.8 0.5 0.5
Medication for cholesterol 1.3 2.0 7.6 -1.7 -2.0 -0.6 0.9 -0.9 -1.1 -2.7 0.1 0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.0 0.1 0.3 0.3 -0.2 -0.0 -0.2 -0.2 0.0 0.2 -0.1 -0.5
Back pain experienced in last month 0.4 0.6 1.0 -0.6 -1.0 -0.3 -0.7 -1.0 -0.9 -0.1 -0.9 -0.8
Mineral and other dietary supplements 1.5 2.0 3.7 -1.3 -0.5 -1.9 0.3 -1.7 -1.9 -1.3 -1.8 -0.8
Breast cancer (self-reported) 0.5 0.5 1.3 0.8 0.8 1.1 -0.1 0.5 1.1 1.0 0.2 0.2
Asthma (self-reported) 2.7 5.3 14.7 -2.0 -3.3 -0.9 -0.2 -3.0 -2.1 -3.8 -1.5 -0.7
Osteoporosis (self-reported) 0.7 0.8 5.5 0.7 0.3 -0.2 0.5 0.8 0.5 2.4 -0.4 -0.3
Osteoarthritis (self-reported) 0.2 0.2 0.6 0.8 0.4 0.5 0.3 0.4 0.4 -0.0 0.3 -0.4
Medication: Aspirin 0.2 0.3 1.0 0.0 1.0 -0.9 0.2 0.1 -0.6 0.5 -0.7 0.1
Medication: Gliclazide 0.6 0.7 3.2 -0.2 0.2 0.4 -1.4 -0.1 -0.2 1.0 -0.3 -1.8
Illnesses of father: None of the above (group 1) 2.0 2.4 4.1 -1.7 -1.3 -1.8 -1.0 -1.8 -1.6 -0.1 -2.0 -1.9
Smoking status: Current 0.5 0.8 3.3 -0.3 1.2 -1.8 0.1 -0.2 -0.6 0.7 -0.7 -1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 3.6 0.0 -0.8 -0.2 0.5 -0.2 -0.5 -1.9 0.4 0.7
Whole body water mass 0.3 1.7 3.9 0.6 1.8 -1.9 2.0 1.2 -0.3 0.9 -0.1 1.2
Leg predicted mass (right) 0.3 1.9 3.9 0.5 1.8 -1.8 2.0 1.5 -0.0 1.4 0.1 1.5
Arm fat mass (left) 0.1 0.4 1.7 0.1 0.7 -0.7 0.7 0.5 0.0 -0.1 0.7 1.3
Number of self-reported non-cancer illnesses 0.5 0.8 2.3 1.5 0.9 1.2 -0.4 0.3 0.9 0.7 0.3 -0.9
Average weekly champagne plus white wine intake 1.7 2.4 4.9 -2.2 -1.3 -2.1 0.2 -1.5 -1.9 -1.3 -1.6 -0.8
Miserableness 0.2 0.4 1.1 -0.2 -0.2 -0.4 -0.9 -0.4 -0.6 0.7 -1.1 -0.2
Guilty feelings 0.2 0.3 1.1 1.1 0.9 0.1 0.4 0.4 0.1 -0.0 0.5 0.5
Wears glasses or contact lenses 0.6 0.7 3.4 0.6 -0.6 0.9 0.5 -0.4 0.3 -1.8 0.7 -0.1
Ever taken oral contraceptive pill 1.1 1.2 2.3 -1.3 -0.2 -1.5 -0.3 -0.8 -1.4 0.6 -1.5 -1.2
Hearing aid user 0.6 0.7 3.2 0.8 0.6 -0.7 1.8 0.2 -0.0 -0.7 0.6 0.9
Mother’s age at death 0.5 0.7 2.6 -0.2 -0.8 0.8 -0.8 -0.3 -0.2 -1.6 1.0 0.5
Financial situation satisfaction 1.8 2.2 5.7 -1.3 -0.6 -2.0 -1.0 -1.7 -1.4 0.4 -2.4 -1.3
Tinnitus: Yes, now most or all of the time 0.7 0.8 2.7 0.6 0.3 0.8 -0.1 1.0 0.7 -0.1 1.6 1.3
Commuting to job workplace: Public transport 0.1 0.2 0.7 0.5 0.3 0.0 0.9 0.1 0.2 0.5 -0.1 -0.3
Eye problems/disorders: Glaucoma 1.2 1.4 2.3 1.2 1.2 1.1 1.3 1.3 1.2 0.0 1.5 1.2
Medication: Blood pressure 1.4 2.7 13.4 1.4 2.3 -0.9 -0.1 0.9 0.5 3.7 -1.4 -0.6
Pain type(s) experienced in last month: Hip pain 0.3 0.4 2.0 0.3 0.2 0.5 -0.5 -0.5 0.2 0.5 -0.4 -1.4
Supplements: Fish oil (including cod liver oil) 2.5 3.2 6.0 1.7 0.7 2.3 0.5 2.0 2.5 1.8 2.1 1.5
High cholesterol (Self-reported) 0.5 0.9 2.4 0.8 1.5 -0.6 1.1 0.9 0.4 1.1 0.4 1.1
Medication: Bendroflumethiazide 0.7 1.1 2.3 1.0 1.4 0.6 -0.4 1.2 1.0 1.5 0.2 1.3
Medication: Paracetamol 1.1 1.6 4.5 2.1 1.6 0.5 1.1 1.0 1.4 1.7 0.2 0.2
Medication: Lisinopril 0.6 0.8 3.6 -0.4 -0.6 -0.0 -1.9 -0.8 -0.4 0.3 -1.1 -1.2
Medication: Atorvastatin 0.1 0.2 0.4 -0.3 0.3 -0.5 -0.6 -0.6 -0.3 0.1 -0.6 -0.3
Illnesses of father: High blood pressure 0.5 0.6 1.1 -0.9 -0.7 -1.1 1.0 -0.2 -0.9 -0.9 -0.6 0.5
Alcohol drinker status: Never 1.3 1.5 3.9 -1.1 -1.5 0.4 -2.0 -1.1 -0.8 -1.6 -0.6 -1.1
Ever smoked 0.4 0.7 1.9 0.4 0.8 0.9 -1.4 0.4 0.4 -0.3 1.1 -1.0
Basal metabolic rate 0.3 1.6 3.7 0.7 1.8 -1.7 1.9 1.3 -0.2 0.9 0.2 1.4
Leg fat percentage (left) 0.3 1.3 4.5 -0.5 -0.3 -0.8 1.1 -0.3 -0.6 -2.1 0.8 1.9
Arm fat-free mass (left) 0.3 1.4 3.8 0.7 1.6 -1.5 2.0 1.1 -0.3 0.2 0.4 1.3
Number of operations (self-reported) 0.4 0.6 1.6 0.5 -0.1 0.9 0.6 0.7 0.9 -0.2 1.3 0.8
Average weekly beer plus cider intake 0.3 0.4 1.2 0.6 1.1 -0.7 -0.0 0.7 -0.1 0.0 0.3 0.8
Irritability 0.6 1.1 4.1 0.8 1.1 0.9 -0.8 1.1 0.9 2.0 -0.2 -0.4
Risk taking 0.9 1.3 3.2 1.8 1.8 -0.1 1.2 1.1 0.9 1.4 0.4 0.3
Ever had prostate specific antigen (PSA) test 0.3 0.4 1.2 0.7 1.1 0.2 0.7 0.5 0.3 0.1 0.7 0.4
Fractured/broken bones in last 5 years 0.7 1.0 2.1 -0.5 -1.3 -1.2 0.4 -1.4 -1.0 -1.0 -0.9 -0.4
Age started oral contraceptive pill 0.6 0.8 2.3 -1.2 -1.5 0.1 -1.0 -0.6 -0.9 -1.1 0.1 0.1
Diastolic blood pressure, automated reading 0.6 1.9 5.1 1.3 1.7 -1.1 1.0 1.4 0.4 2.3 -0.7 1.7
Ever depressed for a whole week 0.5 0.6 1.5 -0.9 -0.8 -0.8 -0.2 -0.7 -1.2 -0.2 -0.7 -0.9
Unable to work because of sickness or disability 0.2 0.3 1.4 0.1 -0.3 0.6 -1.2 -0.0 0.3 0.6 -0.1 0.1
Commuting to job workplace: Cycle 1.1 1.3 3.2 1.4 0.5 1.8 -0.6 1.0 1.1 1.3 1.3 -0.5
Myopia 0.3 0.4 1.4 -0.6 -1.1 0.5 0.0 -0.7 -0.2 -1.2 0.2 -0.0
Vascular/heart problems diagnosed by doctor 0.7 2.0 6.6 -1.8 -2.6 0.6 -0.5 -0.9 -0.7 -2.3 0.7 0.0
Cholesterol lowering medication 0.2 0.2 0.7 0.3 0.4 -0.7 0.3 0.1 -0.1 0.8 -0.1 0.6
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 1.8 -0.4 -0.3 0.0 -1.3 -0.4 -0.2 -0.7 0.1 -0.7
Pain experienced in last month 0.4 0.7 2.2 0.1 0.2 -0.1 0.1 0.8 0.2 -1.0 1.4 1.5
Supplements: Calcium 2.8 3.1 6.9 2.6 2.1 0.6 0.9 2.0 1.9 2.3 1.1 1.0
Basal cell carcinoma (self-reported) 7.7 9.1 17.5 2.8 3.1 2.2 2.5 4.2 3.4 3.6 2.6 2.4
Heart attack/myocardial infarction (self-reported) 0.8 1.0 2.7 1.2 1.4 0.7 -0.7 0.8 1.2 1.6 0.3 -0.3
Deep venous thrombosis (DVT) (self-reported) 1.6 2.0 4.4 1.6 1.1 1.4 1.3 1.2 1.8 0.4 1.4 2.1
Heart disease (siblings) 0.8 0.9 2.0 1.0 0.3 1.0 0.7 1.2 1.2 0.2 1.4 1.1
Alcohol drinker status: Previous 0.5 0.6 1.9 0.2 -0.5 1.4 -0.7 -0.1 0.0 -1.1 0.5 -1.1
Pack years of smoking 0.2 0.3 0.8 -0.6 -0.4 -0.9 0.2 0.1 -0.7 -0.5 -0.1 0.8
Impedance of whole body 0.4 1.8 4.8 0.9 -0.2 2.2 -1.2 1.0 1.9 1.6 1.5 0.3
Leg fat mass (left) 0.2 0.9 3.1 -0.0 0.6 -1.1 1.3 0.4 -0.4 -1.0 0.8 1.8
Arm predicted mass (left) 0.3 1.5 4.1 0.6 1.8 -1.7 2.0 1.1 -0.4 0.4 0.2 1.2