Hub : Genes

C2orf58

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0272	0.0125	6.0e-04	0.015	0.015	0.014	NA	0.015	0.00032	3.0e-04	6.6e-04	NA	0.00032
2	TCGA	Lung Adenocarcinoma	0.0588	0.0252	7.7e-04	0.015	0.017	0.014	NA	0.022	0.00670	3.7e-03	8.9e-03	NA	0.00120
3	TCGA	Ovarian Serous Cystadenocarcinoma	0.1080	0.0560	9.4e-03	0.002	0.025	0.036	NA	0.000	0.22000	7.7e-03	1.7e-03	NA	0.35000
4	TCGA	Prostate Adenocarcinoma	0.0768	0.0376	9.4e-05	0.003	0.037	0.037	NA	0.019	0.14000	9.3e-05	7.8e-05	NA	0.00390
5	TCGA	Thyroid Carcinoma	0.0890	0.0470	3.8e-03	-0.002	0.016	0.011	NA	-0.002	0.51000	1.0e-02	2.8e-02	NA	0.50000

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.1	1.8	4.8	-0.5	-1.5	-2.2	0.4	-1.1
Bipolar Disorder or Schizophrenia	0.6	1.5	2.3	-1.5	-0.9	-1.2	-1.3	-1.1
Depressed Affect (Nagel 2018)	0.3	0.6	1.9	-0.7	1.4	-0.4	0.6	0.3
Depression (Nagel 2018)	0.8	1.2	2.4	-1.5	0.9	-1.6	0.4	-0.7
Intelligence (Savage-Jansen 2018)	1.0	3.0	7.5	2.0	1.1	-0.2	1.5	2.7
Neuroticism (Nagel 2018)	0.1	0.3	0.6	0.3	0.7	-0.2	0.8	-0.2
Schizophrenia (2018)	0.7	1.4	4.1	-1.5	0.1	0.1	-2.0	-0.6
Schizophrenia vs Biploar Disorder	0.6	0.8	2.2	-1.2	0.1	0.1	0.4	-1.5
Worry (Nagel 2018)	0.1	0.3	0.6	0.8	-0.6	0.5	0.5	0.1
Alzheimer’s Disease (in mother)	0.5	0.5	0.8	-0.9	-0.9	-0.6	-0.7	-0.4
Alzheimer’s Disease (in father)	1.6	1.7	6.0	1.0	2.4	0.8	0.5	0.9
Alzheimer’s Disease (including proxy)	0.4	0.6	2.0	-0.0	1.4	-0.1	-0.6	0.6
Crohns Disease (2017)	0.3	0.6	1.5	0.5	0.2	1.2	0.9	-0.3
Irritable Bowel Disease (IBD)	0.3	0.7	2.2	-0.1	-0.6	1.5	0.1	-0.9
Ulcerative Colitis (UC)	0.6	1.1	1.7	-1.1	-1.1	0.7	-0.7	-1.3
Major Depression (MDD)	0.2	0.3	1.0	0.5	-0.1	0.1	-1.0	-0.4
Reaction Time	0.4	0.7	1.4	-0.7	1.2	-0.6	-0.9	-0.8
Verbal and Numeric Reasoning (VNR)	2.4	5.7	8.8	2.8	2.5	1.1	2.1	3.0
Breast Cancer	0.6	1.6	3.5	1.9	0.6	1.3	0.8	1.3
Ovarian Cancer	0.3	0.4	1.0	-1.0	-0.1	-0.5	-0.9	-0.2
Prostate Cancer	0.3	0.4	1.5	-0.0	0.6	0.0	-1.2	0.3
Age at First Birth	0.2	0.3	0.7	-0.4	0.1	-0.2	-0.8	-0.8
Bipolar Disorder (2011)	0.4	0.4	1.1	-0.5	-0.2	-1.0	0.7	-0.4
Body Mass Index (BMI) (2010)	0.2	0.3	0.8	0.5	0.6	0.0	0.9	-0.1
Coronary Artery Disease (CAD)	0.3	0.3	1.1	-0.1	-1.1	0.1	0.1	-0.6
Crohns Disease (2012)	0.6	0.9	2.1	0.6	-0.8	0.9	1.4	-0.8
Mean Putamen Volume	0.9	1.1	1.5	-1.2	-1.1	-1.2	-1.2	-0.1
Fasting Glucose	1.9	2.3	4.0	1.8	1.4	2.0	-0.6	1.4
HbA1C	2.3	2.6	4.6	2.2	0.5	1.9	1.5	1.5
HDL Cholesterol	0.0	0.1	0.2	0.1	0.3	-0.5	0.0	0.2
LDL Cholesterol	0.4	0.6	1.5	-1.2	-0.4	-0.4	0.0	-1.2
Lupus	0.7	1.1	2.7	1.1	-1.6	1.1	0.5	-0.2
Neuroticism (2016)	0.7	1.0	2.8	0.8	0.6	0.1	1.1	1.7
Primary Biliary Cirrhosis	1.2	1.7	5.3	-0.5	-2.3	0.3	-0.2	-1.7
Rheumatoid Arthritis	0.2	0.3	0.7	-0.1	0.5	-0.6	0.1	0.8
Schizophrenia (2014)	0.5	1.1	1.8	-1.3	-0.9	-0.5	-1.0	-1.2
Triglycerides	0.5	0.9	2.5	0.8	1.6	1.1	-0.1	0.4
Type 2 Diabetes (T2D) (2012)	1.1	1.3	3.0	1.5	-0.9	1.7	0.6	-0.0
Ulcerative Colitis	0.9	1.3	2.2	-0.8	-1.2	1.1	-1.2	-1.5
Blood Eosinophil Count	0.5	3.8	8.6	1.4	0.4	2.6	2.9	1.1
Blood Platelet Count	0.4	5.1	10.0	2.8	1.7	2.0	-0.6	3.2
Blood Red Count	0.1	0.5	2.0	0.1	-0.5	0.3	-0.4	-1.4
Blood White Count	0.0	0.2	0.4	-0.7	-0.2	0.4	0.5	-0.3
Heel T-Score	0.0	0.1	0.2	0.3	-0.0	-0.4	-0.2	-0.1
BMI	0.3	2.0	3.5	-1.8	-0.6	-1.9	1.5	-0.8
Height	0.1	2.5	10.2	0.6	0.2	-3.2	-1.1	0.7
Waist Hip Ratio (WHR)	0.1	0.4	1.2	0.5	0.4	-0.4	-0.1	1.1
Systolic Blood Pressure	0.1	0.5	1.7	1.3	0.3	0.4	-0.7	0.2
Smoking Status	0.7	1.7	3.2	-1.3	0.6	-1.8	0.3	-1.7
Allergy or Eczema	0.7	1.8	3.5	-1.1	-1.9	-0.3	-1.1	-1.6
Cardiovascular Disease	1.3	4.2	6.9	-2.5	-0.7	-2.6	-1.7	-2.1
Hypothyroidism (self reported)	0.3	0.7	2.0	-0.5	1.0	0.6	-0.2	1.4
Respiratory disease	1.8	4.0	10.6	1.0	0.9	3.2	2.5	1.1
Type 2 Diabetes (T2D) (2018)	0.3	0.6	2.2	-0.7	0.4	-1.5	0.3	-0.4
Lung FEV1/FVC ratio	0.3	1.7	3.6	1.9	1.4	-1.3	0.0	1.1
Lung FVC	0.1	0.6	1.6	-0.1	-0.8	0.8	1.3	0.3
Neuroticism	0.1	0.1	0.3	0.2	0.5	-0.3	0.1	0.5
Chronotype (morning person)	0.4	0.8	3.1	0.8	0.0	1.8	-0.2	-0.5
Hair Pigment	0.0	1.3	2.9	1.7	0.9	0.8	1.1	1.0
Tanning	1.6	19.0	57.9	1.6	-0.2	7.6	5.6	1.9
Hand grip strength (left)	0.6	1.6	6.8	0.2	-0.8	-0.7	2.6	-0.5
Number of treatments/medications taken	0.3	0.5	1.3	-1.1	0.2	-0.7	-0.9	-0.4
Average weekly spirits intake	1.7	2.1	4.9	-1.8	-1.1	-2.2	1.0	-0.5
Sensitivity / hurt feelings	0.8	1.4	2.8	-1.4	0.1	-1.7	0.4	-1.4
Frequency of depressed mood in last 2 weeks	1.6	2.2	4.8	-2.1	1.1	-2.2	0.3	-0.8
Hearing difficulty/problems: Yes	0.2	0.4	0.8	0.2	0.7	-0.0	0.9	0.8
Relative age of first facial hair	0.4	0.9	2.5	0.3	1.1	-0.6	1.6	0.5
Other serious medical condition/disability diagnosed by doctor	3.2	4.1	6.2	-2.5	-2.4	-1.6	-0.9	-2.3
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.6	-0.3	-1.4	-1.6	0.5	-0.2
Ever had hysterectomy (womb removed)	0.5	0.6	1.2	0.8	-0.1	1.1	0.2	1.1
Systolic blood pressure, automated reading	0.1	0.3	0.5	0.0	-0.2	-0.6	-0.7	-0.6
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.8	-1.3	0.2	-0.9	-0.8	0.0
Angina	0.6	0.8	2.3	0.0	0.6	-0.4	1.0	1.5
Medication for hormone replacement therapy	1.1	1.2	2.4	1.1	0.7	0.9	1.1	1.5
Vitamin and mineral supplements	0.7	0.9	4.1	-0.2	0.2	-0.3	0.6	2.0
Supplements: Zinc	0.2	0.2	0.4	-0.3	0.3	-0.4	0.6	0.4
Medication: Co-codamol	0.3	0.3	1.1	-0.6	-1.0	-0.2	-0.0	0.0
Medication: Metformin	0.8	1.1	2.6	-0.5	0.3	-1.6	-0.4	1.6
Diabetes (father)	0.2	0.3	0.5	-0.5	-0.5	-0.6	-0.3	-0.7
Diabetes (mother)	0.1	0.1	0.3	0.1	-0.1	0.3	-0.6	0.5
Severe depression (siblings)	0.5	0.5	1.4	-1.2	-0.2	-1.0	0.0	-0.5
Pack years adult smoking proportion	0.1	0.2	0.5	0.2	0.6	-0.5	0.7	0.0
Impedance of leg (right)	0.1	0.6	2.6	0.6	0.5	1.6	0.2	-0.0
Leg fat-free mass (left)	0.5	2.6	9.8	-1.7	-0.4	-3.1	-0.3	-0.4
Trunk fat percentage	0.4	1.5	2.1	-1.3	-1.1	-1.3	0.8	-1.4
Hand grip strength (right)	0.3	0.7	1.3	-0.3	-1.1	-1.1	0.5	-0.8
Townsend deprivation index at recruitment	0.2	0.3	0.5	0.7	-0.5	0.4	0.6	0.6
Current tobacco smoking	2.4	3.9	8.1	-2.8	0.0	-2.8	-0.4	-1.9
Average weekly fortified wine intake	0.7	0.8	2.3	0.3	0.2	1.5	-0.5	-1.2
Maternal smoking around birth	0.8	1.2	4.6	-1.1	-0.0	-2.1	0.1	-0.1
Fed-up feelings	1.1	1.9	8.1	-0.6	2.8	-0.5	0.0	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	3.3	-1.0	1.8	-0.3	0.5	0.0
Relative age voice broke	0.1	0.2	0.6	0.6	0.1	0.8	-0.3	-0.2
Taking other prescription medications	0.5	0.8	1.6	-0.2	1.2	0.9	1.0	0.9
Age when periods started (menarche)	0.1	0.1	0.4	-0.1	-0.4	0.2	0.7	0.1
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	2.1	0.5	-0.6	0.3	1.5	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	2.3	0.2	1.5	1.0	-0.2	0.5
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.2	0.4	0.5	1.1	0.7	-1.0
Qualifications: CSEs or equivalent	0.7	0.9	4.0	0.0	0.1	0.5	2.0	-0.2
Serious illness, injury or assault to yourself	1.0	1.2	2.7	0.6	1.7	0.7	1.0	1.3
High blood pressure	0.4	1.1	2.7	-1.0	-0.3	-1.6	-1.1	-0.7
Hayfever, allergic rhinitis or eczema	0.7	1.4	4.0	-0.6	-2.0	-0.4	-1.2	-1.1
Multivitamins +/- minerals	0.9	1.2	4.0	0.4	0.1	0.7	-1.1	-2.0
Stomach or abdominal pain in last month	2.9	3.6	7.4	1.3	2.7	2.4	1.4	1.3
Supplements: Glucosamine	1.0	1.3	3.9	0.2	-1.1	-0.1	1.1	-2.0
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.3	0.8	-0.4	1.1	0.0	-1.1
Medication: Atenolol	1.6	2.0	4.2	-0.7	2.1	-0.6	-2.0	1.0
Medication: Levothyroxine sodium	0.7	1.2	3.1	-1.8	0.9	-0.0	-0.7	-1.2
Sitting height	0.1	1.0	4.3	0.4	0.4	-2.1	0.1	0.5
Chronic bronchitis/emphysema (father)	0.7	0.9	3.1	0.2	0.4	1.0	1.8	0.3
High blood pressure (mother)	0.2	0.3	0.9	-0.3	0.9	-0.2	-0.3	0.7
Body mass index (BMI)	0.6	2.7	5.9	-2.2	-0.6	-2.4	1.1	-0.9
Impedance of leg (left)	0.2	0.8	3.2	0.9	0.1	1.8	0.1	-0.2
Leg predicted mass (left)	0.5	2.5	9.5	-1.6	-0.4	-3.1	-0.4	-0.4
Trunk fat mass	0.4	1.8	4.1	-1.5	-0.9	-2.0	0.6	-1.3
Waist circumference	0.7	2.7	8.0	-2.1	-0.4	-2.8	0.8	-0.4
Number of incorrect matches in round	0.2	0.3	1.3	1.1	-0.3	0.3	0.0	-0.1
Past tobacco smoking	0.4	0.6	1.4	1.2	-0.3	0.7	0.2	1.1
Alcohol usually taken with meals	2.3	3.7	8.7	3.0	0.3	2.9	-0.3	1.1
Nervous feelings	0.8	1.5	2.8	1.5	1.7	1.2	0.8	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	2.3	-0.3	1.5	-0.4	0.1	0.6
Hearing difficulty/problems with background noise	1.4	2.2	3.5	1.9	1.4	1.2	1.2	1.7
Hair/balding pattern: Pattern 2	1.0	1.3	2.7	-1.6	0.3	-1.6	-0.8	0.8
Had menopause	2.1	2.7	5.9	2.4	0.0	1.9	1.5	1.3
Had other major operations	0.8	1.0	2.1	0.7	0.6	1.5	-0.6	1.3
Forced vital capacity (FVC)	0.1	0.2	0.8	-0.2	-0.1	0.4	-0.9	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.5	-0.4	0.5	-0.1	-0.7	-0.4
Ever unenthusiastic/disinterested for a whole week	2.4	3.0	5.8	-1.9	1.1	-1.3	-2.4	-1.6
Qualifications: None of the above	0.4	0.9	2.2	0.3	1.4	-0.4	1.5	-0.0
Financial difficulties in last 2 years	0.5	0.7	1.8	-0.9	1.4	-0.7	-0.6	-0.2
Mouth/teeth dental problems	0.2	0.4	1.0	-0.0	0.6	0.3	-1.0	-0.7
Heart attack	0.5	0.6	1.3	-0.2	1.2	-0.0	-1.1	0.8
Allergy	0.3	0.6	1.4	0.2	1.2	-0.9	0.0	0.9
Pain all over the body in last month	0.1	0.1	0.3	0.1	-0.4	0.5	0.3	0.0
Diabetes (self-reported)	0.3	0.4	1.0	0.4	0.7	-0.6	0.2	1.0
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.8	-0.1	1.0	0.3	0.6	1.3
Medication: Ramipril	1.1	1.4	2.1	-1.0	-0.9	-1.4	-1.2	1.2
Medication: Simvastatin	0.5	0.7	2.1	-0.6	0.7	-0.4	-1.4	-0.5
Fluid intelligence score	2.0	4.1	7.5	2.7	1.8	1.2	1.1	2.6
Illnesses of siblings	0.2	0.3	0.6	0.3	-0.8	0.8	0.1	0.6
Neuroticism score	0.1	0.2	1.0	-0.2	1.0	-0.3	0.4	0.0
Weight	0.6	3.0	9.6	-1.9	-0.7	-3.1	0.5	-0.9
Impedance of arm (right)	0.4	1.8	5.5	1.4	-0.6	2.3	-0.6	-0.9
Arm fat percentage (right)	0.4	1.6	2.9	-1.7	-0.8	-1.3	0.8	-1.5
Trunk fat-free mass	0.3	1.6	7.1	-0.9	0.3	-2.7	0.2	0.4
Hip circumference	0.7	3.1	8.2	-2.2	-1.0	-2.9	0.5	-1.1
Time employed in main current job	1.4	1.6	5.5	1.1	-0.1	-0.9	2.3	0.6
Alcohol intake versus 10 years previously	0.3	0.4	1.1	-0.0	0.2	-1.1	1.0	-0.0
Father’s age at death	2.3	3.1	5.1	2.3	2.0	1.6	0.9	1.8
Worrier / anxious feelings	0.1	0.2	0.6	-0.3	-0.2	-0.2	-0.3	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	4.0	-0.9	1.1	-2.0	-0.3	0.3
Falls in the last year	0.6	0.9	3.0	0.2	0.5	0.8	-1.7	0.6
Hair/balding pattern: Pattern 3	0.7	1.0	2.5	1.6	0.4	1.3	0.2	0.8
Number of live births	0.6	0.9	2.9	0.6	1.0	0.1	0.2	1.7
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	2.0	-0.3	-0.6	-0.4	-1.4	0.4
Pulse rate	0.5	0.8	1.7	-1.1	-0.6	-1.3	0.5	-0.6
Happiness	1.4	1.8	3.9	-1.4	0.4	-0.5	-2.0	-1.6
Noisy workplace	2.8	3.5	8.6	-1.8	-1.4	-2.9	1.0	-1.5
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.4	-0.1	-0.1	1.2	-0.9	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.4	-0.8	-0.7	-0.6	-1.2	-1.0
Mouth/teeth dental problems: Dentures	2.4	4.0	7.9	2.8	-0.2	2.2	2.0	1.7
Asthma	1.9	3.8	13.0	0.8	1.0	3.6	2.0	0.6
Medication: Ibuprofen (e.g. Nurofen)	6.0	7.6	13.2	-3.6	-2.8	-2.3	-2.7	-2.0
Medication: Cholesterol lowering	1.3	2.0	5.2	-1.2	-1.0	-1.6	-2.3	-0.1
Depression (self-reported)	1.1	1.3	2.0	1.2	0.6	1.0	1.3	1.4
Medication: Lansoprazole	0.2	0.3	0.5	-0.4	0.1	-0.7	0.7	-0.4
Prospective memory result	0.6	0.7	2.5	0.6	-0.8	1.6	-0.3	0.2
Lung cancer (father)	1.3	1.5	2.6	-1.6	-1.1	-1.4	-0.8	-1.1
Illnesses of mother	0.8	0.9	1.6	1.1	-0.3	1.2	1.3	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.6	-0.0	-1.0	-0.7	-1.2	0.5
Pulse wave Arterial Stiffness index	0.8	1.0	2.0	0.0	-1.4	-1.1	-0.1	-1.3
Impedance of arm (left)	0.3	1.6	5.0	1.2	-0.5	2.2	-1.1	-0.3
Arm fat mass (right)	0.5	2.2	5.4	-2.0	-0.5	-2.3	0.6	-1.0
Trunk predicted mass	0.3	1.5	6.4	-0.8	0.3	-2.5	0.3	0.5
Standing height	0.1	0.9	2.8	0.6	-0.0	-1.7	-1.1	0.4
Length of working week for main job	0.8	0.9	3.2	-0.4	-0.4	0.1	-1.0	-1.8
Exposure to tobacco smoke at home	0.6	0.7	2.5	0.2	1.6	0.3	0.2	0.8
Breastfed as a baby	1.4	1.7	2.9	0.6	1.7	1.4	-1.7	0.7
Tense / ‘highly strung’	0.1	0.2	0.5	0.4	-0.7	0.1	-0.3	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.9	-0.9	-0.0	-0.5	0.5	-0.1
Hair/balding pattern: Pattern 4	0.1	0.4	0.7	-0.3	-0.8	-0.6	0.2	-0.9
Birth weight of first child	0.5	1.0	2.6	1.1	0.9	0.5	1.6	-0.0
Peak expiratory flow (PEF)	0.5	1.1	3.9	-0.7	0.5	-0.9	-2.0	0.3
Pulse wave reflection index	0.8	1.0	3.5	1.9	-0.9	0.2	0.4	0.7
Ever highly irritable/argumentative for 2 days	2.8	3.3	6.7	-2.6	-0.1	-1.6	-2.1	-1.8
Loud music exposure frequency	0.2	0.2	0.7	0.5	0.3	0.8	0.1	0.3
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.9	0.0	-0.6	0.9	-0.2	0.0
Mouth/teeth dental problems: Bleeding gums	2.5	3.3	6.5	-1.9	-2.5	-2.2	-0.7	-1.0
Blood clot in the leg (DVT)	0.8	1.0	4.3	-0.2	-0.7	0.4	-0.0	-2.1
Medication: Paracetamol	0.8	1.4	1.7	-1.3	-1.2	-1.0	-1.0	-1.3
Headache pain in last month	0.8	1.3	3.8	0.5	0.6	1.0	1.9	1.1
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.6	0.7	0.4	1.3	0.9	-0.6
Glaucoma (self-reported)	0.8	1.0	2.8	0.3	-1.7	-0.6	1.2	-0.2
Gout (self-reported)	0.1	0.2	0.6	-0.4	-0.0	-0.0	-0.5	-0.7
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	2.9	-0.5	1.7	0.7	0.6	0.8
Medication: Amlodipine	1.8	2.6	5.8	-2.2	1.1	-1.1	-2.4	-0.1
Medication: Ventolin 100micrograms inhaler	3.2	4.1	10.5	0.8	1.4	2.2	3.2	1.6
Birth weight	0.9	1.9	5.6	-1.6	-0.4	-2.4	-1.0	-0.1
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.5	-0.0	1.0	1.2	0.8	0.2
High blood pressure (siblings)	0.4	0.5	1.7	-0.6	0.2	-0.6	-1.3	-0.5
Forced vital capacity (FVC), Best measure	0.1	0.3	0.7	-0.2	-0.4	-0.7	-0.3	0.8
Body fat percentage	0.4	1.5	2.5	-1.6	-0.9	-1.3	0.9	-1.4
Leg fat percentage (right)	0.4	1.5	2.6	-1.6	-0.2	-1.1	1.5	-1.1
Arm fat-free mass (right)	0.5	2.6	10.9	-1.4	-0.3	-3.3	0.1	0.2
Exposure to tobacco smoke outside home	0.6	0.7	1.4	-0.8	-1.0	-0.6	1.2	-0.6
Comparative body size at age 10	0.2	0.5	0.9	-0.5	-0.3	0.6	0.9	-0.9
Number of full brothers	0.3	0.4	1.1	-0.7	-0.0	-1.1	-0.1	0.7
Worry too long after embarrassment	0.1	0.1	0.5	-0.2	-0.1	-0.4	0.2	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.8	-0.9	0.0	-0.2	0.2	0.4
Wheeze or whistling in the chest in last year	1.2	2.1	4.0	0.4	1.6	1.9	2.0	-0.1
Number of children fathered	0.5	0.6	1.9	-0.6	0.1	-1.4	0.7	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	3.5	0.0	-1.9	-0.1	1.2	-0.1
Age at first live birth	0.6	1.0	2.4	1.5	1.1	0.9	-0.4	0.7
Pulse wave peak to peak time	0.9	1.0	2.0	0.2	1.4	1.1	0.0	1.4
Health satisfaction	0.9	1.2	2.6	-1.2	0.1	-0.9	-1.0	-1.6
Shortness of breath walking on level ground	1.6	1.9	4.5	-2.1	0.0	-1.4	-0.9	-1.5
Qualifications: College or University degree	0.2	0.7	2.8	0.2	0.3	0.7	-1.7	-0.5
Eye problems/disorders: None of the above	0.5	0.6	2.1	0.5	0.7	1.5	0.3	0.3
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.0	0.4	-1.1	1.4	0.3	0.4
Emphysema/chronic bronchitis	0.5	0.5	1.3	-1.1	0.2	0.1	1.1	0.3
Medication for pain relief, constipation, heartburn	0.3	0.6	1.2	1.1	0.2	0.9	0.9	0.2
Neck or shoulder pain in last month	0.5	0.8	1.5	-0.6	1.2	0.6	-0.3	-1.2
Medication: Blood pressure	0.2	0.4	0.8	-0.8	-0.0	-0.9	-0.6	0.5
Angina (self-reported)	0.5	0.6	2.0	0.1	0.6	-0.4	0.8	1.4
Migraine (self-reported)	0.4	0.5	1.3	0.8	-0.0	1.1	-0.2	0.9
Medication: Ibuprofen	5.5	6.6	11.0	-3.3	-2.4	-2.6	-2.2	-2.2
Medication: Allopurinol	0.3	0.3	0.7	0.9	0.5	0.8	-0.1	0.0
Medication: Omeprazole	0.2	0.3	1.2	-0.1	1.1	-0.0	0.4	0.1
Medication: Seretide 50 evohaler	0.5	0.5	1.4	-0.2	0.9	1.2	0.6	0.2
Mean time to correctly identify matches	0.3	0.6	1.7	-0.1	1.3	0.1	-0.9	-0.7
Heart disease (mother)	0.7	0.9	2.1	-0.3	-0.1	-1.4	-0.3	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	1.6	-1.2	0.0	0.5	-1.2	-1.2
Whole body fat mass	0.5	2.2	5.3	-1.9	-0.7	-2.3	0.5	-1.2
Leg fat mass (right)	0.7	2.6	6.1	-2.1	-0.6	-2.5	1.0	-1.1
Arm predicted mass (right)	0.6	3.0	12.4	-1.6	0.2	-3.5	-0.2	0.3
Pulse rate, automated reading	0.1	0.2	0.8	0.1	0.4	0.3	0.9	-0.1
Alcohol intake frequency.	0.2	0.4	1.3	0.5	0.6	-0.3	1.1	-0.3
Comparative height size at age 10	0.1	0.4	0.9	0.3	0.6	-0.9	-0.4	0.8
Number of full sisters	0.6	0.7	1.4	-1.2	-0.3	-0.9	0.7	-0.8
Suffer from ‘nerves’	0.1	0.1	0.5	-0.2	0.7	-0.3	0.1	0.3
Overall health rating	0.5	1.2	2.4	-1.4	1.0	-1.6	-0.5	0.3
Chest pain or discomfort	1.2	1.8	4.4	-1.5	2.1	-0.3	1.5	0.3
Had major operations	1.2	1.4	2.6	1.0	-1.4	-0.0	1.6	-1.2
Age at last live birth	0.6	0.9	3.1	0.5	1.8	-0.3	-0.1	1.0
Family relationship satisfaction	0.9	1.1	2.8	-0.4	-0.1	0.3	-1.6	-1.7
Leg pain on walking	0.2	0.3	0.6	-0.8	0.1	-0.0	-0.5	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.1	1.1	-0.4	-0.5	1.0	1.0
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.3	1.5	-0.6	1.0	0.4	0.8
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	1.3	1.0	-0.3	0.8	1.1	0.8
Medication: Aspirin	0.3	0.4	0.7	-0.6	0.9	-0.7	-0.1	0.5
Supplements: Vitamin C	0.7	0.9	2.9	-0.1	-1.7	-0.9	0.0	-0.8
Knee pain experienced in last month	0.6	0.9	2.4	-1.2	-0.3	-0.0	-0.9	-1.5
Hypertension (Self-reported)	0.4	1.2	3.8	-1.0	0.0	-1.9	-1.1	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.0	0.3	1.1	-0.3	-1.1	1.4
Illnesses of father: Heart disease	1.9	2.6	3.7	1.6	1.9	1.9	0.1	1.8
Illnesses of siblings: Diabetes	1.7	2.1	3.3	1.8	0.9	1.0	1.8	1.4
Smoking status: Previous	0.4	0.6	1.4	0.7	1.0	1.2	0.4	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	2.0	0.6	0.3	-0.2	-0.3	1.4
Whole body fat-free mass	0.4	2.3	9.7	-1.4	0.1	-3.1	-0.2	0.1
Leg fat-free mass (right)	0.5	2.6	9.5	-1.6	-0.5	-3.1	-0.6	-0.5
Arm fat percentage (left)	0.4	1.7	3.5	-1.9	-0.8	-1.5	0.6	-1.3
Average weekly red wine intake	1.0	1.4	2.3	1.5	0.0	1.3	-1.3	1.2
Handedness (chirality/laterality): Left-handed	1.1	1.3	2.2	-0.9	-1.4	-0.3	1.2	-1.5
Mood swings	0.6	1.1	4.2	-0.9	2.1	-0.3	-0.2	0.5
Loneliness, isolation	1.1	1.5	4.0	-1.6	0.3	-2.0	0.8	-0.4
Long-standing illness, disability or infirmity	0.5	0.8	3.2	-0.7	1.8	0.1	-0.1	0.1
Ever had bowel cancer screening	0.2	0.3	0.7	0.2	-0.3	-0.7	0.9	0.2
Diabetes diagnosed by doctor	0.4	0.6	1.3	-0.9	0.2	-1.1	-0.9	0.2
Ever had stillbirth, spontaneous miscarriage or termination	2.2	2.3	7.6	-1.9	0.2	-2.8	0.6	-0.0
Friendships satisfaction	0.4	0.5	1.1	-0.6	0.5	0.4	-1.1	-0.8
Qualifications: nursing, teaching	0.8	1.3	4.6	-0.3	-0.2	1.2	-2.1	0.5
Commuting to job workplace: Walk	0.2	0.2	1.0	0.0	0.2	1.0	-0.1	0.0
Eye problems/disorders: Cataract	0.2	0.2	0.6	0.4	0.6	0.1	-0.8	0.1
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	5.2	-2.3	0.5	-1.2	-0.8	-1.3
Medication for cholesterol	1.0	1.5	4.4	1.0	-0.6	2.1	1.1	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	2.8	-0.8	-0.7	-1.7	0.9	-0.3
Back pain experienced in last month	0.4	0.6	1.0	0.9	0.6	0.8	-0.0	1.0
Mineral and other dietary supplements	1.0	1.4	4.6	0.1	0.9	-0.3	1.2	2.1
Breast cancer (self-reported)	1.2	1.4	4.1	0.1	1.2	1.3	-2.0	0.2
Asthma (self-reported)	2.0	3.9	13.0	0.8	0.7	3.6	2.3	0.6
Osteoporosis (self-reported)	1.0	1.2	2.3	-1.5	-0.4	-1.2	-1.3	-0.8
Osteoarthritis (self-reported)	0.9	1.1	2.2	-1.5	0.9	-0.4	-0.8	-1.4
Medication: Aspirin	0.6	0.7	2.3	-0.5	1.5	-0.7	-0.0	0.8
Medication: Gliclazide	0.5	0.6	1.6	-0.7	-0.4	-0.7	-1.3	-0.6
Illnesses of father: None of the above (group 1)	1.4	1.7	2.2	-1.1	-1.5	-0.8	-1.5	-1.4
Smoking status: Current	2.8	4.5	8.9	-2.9	0.1	-3.0	-0.5	-2.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	3.0	1.0	-1.7	0.6	0.2	-0.1
Whole body water mass	0.4	2.3	9.6	-1.4	-0.0	-3.1	-0.3	0.1
Leg predicted mass (right)	0.5	2.5	9.7	-1.5	-0.5	-3.1	-0.5	-0.4
Arm fat mass (left)	0.6	2.4	5.6	-2.0	-0.9	-2.4	0.5	-1.0
Number of self-reported non-cancer illnesses	0.1	0.2	0.5	0.1	0.7	0.0	0.4	0.2
Average weekly champagne plus white wine intake	0.3	0.5	1.2	0.2	-0.1	-0.2	-1.0	1.1
Miserableness	0.5	0.9	2.8	-0.4	1.7	-0.3	1.2	0.4
Guilty feelings	0.1	0.1	0.5	-0.0	0.1	-0.7	-0.0	-0.0
Wears glasses or contact lenses	0.9	1.1	2.6	1.4	0.5	1.6	0.6	0.6
Ever taken oral contraceptive pill	1.8	2.0	3.8	-1.9	-0.4	-1.7	-1.9	-0.2
Hearing aid user	1.3	1.4	2.7	-1.6	1.0	-1.6	0.6	-0.8
Mother’s age at death	0.5	0.6	2.5	0.3	-1.6	0.5	0.6	0.0
Financial situation satisfaction	0.5	0.7	1.8	-1.3	0.3	-0.7	-0.6	-0.7
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	0.3	-0.1	0.1	-0.5	-0.4
Commuting to job workplace: Public transport	0.3	0.3	0.8	-0.9	0.5	-0.5	-0.6	-0.3
Eye problems/disorders: Glaucoma	0.6	0.7	3.1	-0.3	-1.8	-0.6	0.3	-0.1
Medication: Blood pressure	0.9	1.8	5.5	-0.6	-0.5	-2.4	-1.7	0.3
Pain type(s) experienced in last month: Hip pain	0.8	1.0	3.3	-1.2	-0.1	-0.5	-1.8	0.1
Supplements: Fish oil (including cod liver oil)	1.5	1.9	3.6	0.8	-1.9	1.2	-1.3	-1.5
High cholesterol (Self-reported)	0.8	1.5	3.4	-1.4	-0.4	-1.1	-1.9	-0.9
Medication: Bendroflumethiazide	0.6	0.9	3.4	0.8	-0.4	-0.7	0.0	1.9
Medication: Paracetamol	0.6	0.9	1.3	-0.8	-0.9	-0.5	-1.1	-1.2
Medication: Lisinopril	0.4	0.5	2.1	0.2	-1.4	0.2	-0.5	0.1
Medication: Atorvastatin	1.2	1.5	3.6	-0.8	1.9	-1.1	-0.5	1.3
Illnesses of father: High blood pressure	0.6	0.8	2.3	-0.2	-0.7	-0.8	1.5	0.4
Alcohol drinker status: Never	3.5	4.2	6.0	2.2	2.4	2.0	0.4	2.5
Ever smoked	0.8	1.5	2.7	-1.6	-0.5	-1.4	-0.1	-1.6
Basal metabolic rate	0.5	2.6	10.2	-1.7	-0.1	-3.2	-0.1	-0.2
Leg fat percentage (left)	0.4	1.4	2.8	-1.2	-0.4	-1.0	1.7	-1.2
Arm fat-free mass (left)	0.5	2.4	9.6	-1.4	-0.2	-3.1	0.3	0.1
Number of operations (self-reported)	0.1	0.2	0.8	-0.1	-0.5	0.2	-0.0	-0.9
Average weekly beer plus cider intake	0.3	0.5	0.9	0.1	0.9	-0.9	0.9	0.3
Irritability	0.8	1.3	2.6	1.6	1.6	0.5	0.6	0.8
Risk taking	0.8	1.1	2.3	-0.8	-1.5	-1.1	-0.4	-1.2
Ever had prostate specific antigen (PSA) test	0.5	0.6	2.4	-0.7	0.1	-0.3	-1.6	-0.3
Fractured/broken bones in last 5 years	0.4	0.5	1.8	-1.3	-0.1	-0.5	0.1	0.5
Age started oral contraceptive pill	0.5	0.6	1.3	1.1	0.4	1.1	0.3	-0.5
Diastolic blood pressure, automated reading	0.2	0.7	2.3	0.4	-0.3	-1.5	-0.6	-0.7
Ever depressed for a whole week	0.4	0.5	0.9	-1.0	0.0	-0.6	-0.7	-0.7
Unable to work because of sickness or disability	1.7	2.2	4.9	1.1	2.2	1.4	0.9	1.4
Commuting to job workplace: Cycle	0.1	0.1	0.3	0.1	-0.1	-0.4	-0.6	-0.4
Myopia	1.1	1.6	2.9	1.4	-0.6	1.6	1.7	0.6
Vascular/heart problems diagnosed by doctor	0.5	1.3	3.4	1.1	0.5	1.9	1.1	0.3
Cholesterol lowering medication	0.9	1.3	1.8	-1.3	1.0	-1.1	-1.0	-1.4
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.6	0.7	1.6	0.8	0.3	0.4
Pain experienced in last month	0.4	0.7	2.1	0.4	-1.4	-0.8	0.9	0.1
Supplements: Calcium	2.3	2.6	5.4	-1.0	-1.8	-1.7	-0.6	-2.3
Basal cell carcinoma (self-reported)	1.2	1.4	5.4	-0.0	-0.2	-0.9	-2.3	-0.8
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.4	0.0	1.2	-0.0	-0.8	1.2
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	3.7	-0.3	-1.1	0.4	0.1	-1.9
Heart disease (siblings)	0.5	0.6	1.4	0.3	-0.3	-1.1	1.2	0.2
Alcohol drinker status: Previous	2.4	2.8	4.7	2.1	1.2	1.6	2.2	0.8
Pack years of smoking	0.3	0.4	1.6	0.5	0.5	-0.3	1.3	-0.1
Impedance of whole body	0.4	1.8	6.4	1.4	-0.1	2.5	-0.7	0.0
Leg fat mass (left)	0.6	2.5	6.1	-1.9	-0.7	-2.5	1.1	-1.1
Arm predicted mass (left)	0.5	2.6	10.4	-1.7	-0.1	-3.2	0.1	-0.0