Hub : Genes

C2orf58

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Breast Invasive Carcinoma 0.0272 0.0125 6.0e-04 0.015 0.015 0.014 NA 0.015 0.00032 3.0e-04 6.6e-04 NA 0.00032
2 TCGA Lung Adenocarcinoma 0.0588 0.0252 7.7e-04 0.015 0.017 0.014 NA 0.022 0.00670 3.7e-03 8.9e-03 NA 0.00120
3 TCGA Ovarian Serous Cystadenocarcinoma 0.1080 0.0560 9.4e-03 0.002 0.025 0.036 NA 0.000 0.22000 7.7e-03 1.7e-03 NA 0.35000
4 TCGA Prostate Adenocarcinoma 0.0768 0.0376 9.4e-05 0.003 0.037 0.037 NA 0.019 0.14000 9.3e-05 7.8e-05 NA 0.00390
5 TCGA Thyroid Carcinoma 0.0890 0.0470 3.8e-03 -0.002 0.016 0.011 NA -0.002 0.51000 1.0e-02 2.8e-02 NA 0.50000

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 1.1 1.8 4.8 -0.5 -1.5 -2.2 0.4 -1.1
Bipolar Disorder or Schizophrenia 0.6 1.5 2.3 -1.5 -0.9 -1.2 -1.3 -1.1
Depressed Affect (Nagel 2018) 0.3 0.6 1.9 -0.7 1.4 -0.4 0.6 0.3
Depression (Nagel 2018) 0.8 1.2 2.4 -1.5 0.9 -1.6 0.4 -0.7
Intelligence (Savage-Jansen 2018) 1.0 3.0 7.5 2.0 1.1 -0.2 1.5 2.7
Neuroticism (Nagel 2018) 0.1 0.3 0.6 0.3 0.7 -0.2 0.8 -0.2
Schizophrenia (2018) 0.7 1.4 4.1 -1.5 0.1 0.1 -2.0 -0.6
Schizophrenia vs Biploar Disorder 0.6 0.8 2.2 -1.2 0.1 0.1 0.4 -1.5
Worry (Nagel 2018) 0.1 0.3 0.6 0.8 -0.6 0.5 0.5 0.1
Alzheimer’s Disease (in mother) 0.5 0.5 0.8 -0.9 -0.9 -0.6 -0.7 -0.4
Alzheimer’s Disease (in father) 1.6 1.7 6.0 1.0 2.4 0.8 0.5 0.9
Alzheimer’s Disease (including proxy) 0.4 0.6 2.0 -0.0 1.4 -0.1 -0.6 0.6
Crohns Disease (2017) 0.3 0.6 1.5 0.5 0.2 1.2 0.9 -0.3
Irritable Bowel Disease (IBD) 0.3 0.7 2.2 -0.1 -0.6 1.5 0.1 -0.9
Ulcerative Colitis (UC) 0.6 1.1 1.7 -1.1 -1.1 0.7 -0.7 -1.3
Major Depression (MDD) 0.2 0.3 1.0 0.5 -0.1 0.1 -1.0 -0.4
Reaction Time 0.4 0.7 1.4 -0.7 1.2 -0.6 -0.9 -0.8
Verbal and Numeric Reasoning (VNR) 2.4 5.7 8.8 2.8 2.5 1.1 2.1 3.0
Breast Cancer 0.6 1.6 3.5 1.9 0.6 1.3 0.8 1.3
Ovarian Cancer 0.3 0.4 1.0 -1.0 -0.1 -0.5 -0.9 -0.2
Prostate Cancer 0.3 0.4 1.5 -0.0 0.6 0.0 -1.2 0.3
Age at First Birth 0.2 0.3 0.7 -0.4 0.1 -0.2 -0.8 -0.8
Bipolar Disorder (2011) 0.4 0.4 1.1 -0.5 -0.2 -1.0 0.7 -0.4
Body Mass Index (BMI) (2010) 0.2 0.3 0.8 0.5 0.6 0.0 0.9 -0.1
Coronary Artery Disease (CAD) 0.3 0.3 1.1 -0.1 -1.1 0.1 0.1 -0.6
Crohns Disease (2012) 0.6 0.9 2.1 0.6 -0.8 0.9 1.4 -0.8
Mean Putamen Volume 0.9 1.1 1.5 -1.2 -1.1 -1.2 -1.2 -0.1
Fasting Glucose 1.9 2.3 4.0 1.8 1.4 2.0 -0.6 1.4
HbA1C 2.3 2.6 4.6 2.2 0.5 1.9 1.5 1.5
HDL Cholesterol 0.0 0.1 0.2 0.1 0.3 -0.5 0.0 0.2
LDL Cholesterol 0.4 0.6 1.5 -1.2 -0.4 -0.4 0.0 -1.2
Lupus 0.7 1.1 2.7 1.1 -1.6 1.1 0.5 -0.2
Neuroticism (2016) 0.7 1.0 2.8 0.8 0.6 0.1 1.1 1.7
Primary Biliary Cirrhosis 1.2 1.7 5.3 -0.5 -2.3 0.3 -0.2 -1.7
Rheumatoid Arthritis 0.2 0.3 0.7 -0.1 0.5 -0.6 0.1 0.8
Schizophrenia (2014) 0.5 1.1 1.8 -1.3 -0.9 -0.5 -1.0 -1.2
Triglycerides 0.5 0.9 2.5 0.8 1.6 1.1 -0.1 0.4
Type 2 Diabetes (T2D) (2012) 1.1 1.3 3.0 1.5 -0.9 1.7 0.6 -0.0
Ulcerative Colitis 0.9 1.3 2.2 -0.8 -1.2 1.1 -1.2 -1.5
Blood Eosinophil Count 0.5 3.8 8.6 1.4 0.4 2.6 2.9 1.1
Blood Platelet Count 0.4 5.1 10.0 2.8 1.7 2.0 -0.6 3.2
Blood Red Count 0.1 0.5 2.0 0.1 -0.5 0.3 -0.4 -1.4
Blood White Count 0.0 0.2 0.4 -0.7 -0.2 0.4 0.5 -0.3
Heel T-Score 0.0 0.1 0.2 0.3 -0.0 -0.4 -0.2 -0.1
BMI 0.3 2.0 3.5 -1.8 -0.6 -1.9 1.5 -0.8
Height 0.1 2.5 10.2 0.6 0.2 -3.2 -1.1 0.7
Waist Hip Ratio (WHR) 0.1 0.4 1.2 0.5 0.4 -0.4 -0.1 1.1
Systolic Blood Pressure 0.1 0.5 1.7 1.3 0.3 0.4 -0.7 0.2
Smoking Status 0.7 1.7 3.2 -1.3 0.6 -1.8 0.3 -1.7
Allergy or Eczema 0.7 1.8 3.5 -1.1 -1.9 -0.3 -1.1 -1.6
Cardiovascular Disease 1.3 4.2 6.9 -2.5 -0.7 -2.6 -1.7 -2.1
Hypothyroidism (self reported) 0.3 0.7 2.0 -0.5 1.0 0.6 -0.2 1.4
Respiratory disease 1.8 4.0 10.6 1.0 0.9 3.2 2.5 1.1
Type 2 Diabetes (T2D) (2018) 0.3 0.6 2.2 -0.7 0.4 -1.5 0.3 -0.4
Lung FEV1/FVC ratio 0.3 1.7 3.6 1.9 1.4 -1.3 0.0 1.1
Lung FVC 0.1 0.6 1.6 -0.1 -0.8 0.8 1.3 0.3
Neuroticism 0.1 0.1 0.3 0.2 0.5 -0.3 0.1 0.5
Chronotype (morning person) 0.4 0.8 3.1 0.8 0.0 1.8 -0.2 -0.5
Hair Pigment 0.0 1.3 2.9 1.7 0.9 0.8 1.1 1.0
Tanning 1.6 19.0 57.9 1.6 -0.2 7.6 5.6 1.9
Hand grip strength (left) 0.6 1.6 6.8 0.2 -0.8 -0.7 2.6 -0.5
Number of treatments/medications taken 0.3 0.5 1.3 -1.1 0.2 -0.7 -0.9 -0.4
Average weekly spirits intake 1.7 2.1 4.9 -1.8 -1.1 -2.2 1.0 -0.5
Sensitivity / hurt feelings 0.8 1.4 2.8 -1.4 0.1 -1.7 0.4 -1.4
Frequency of depressed mood in last 2 weeks 1.6 2.2 4.8 -2.1 1.1 -2.2 0.3 -0.8
Hearing difficulty/problems: Yes 0.2 0.4 0.8 0.2 0.7 -0.0 0.9 0.8
Relative age of first facial hair 0.4 0.9 2.5 0.3 1.1 -0.6 1.6 0.5
Other serious medical condition/disability diagnosed by doctor 3.2 4.1 6.2 -2.5 -2.4 -1.6 -0.9 -2.3
Ever used hormone-replacement therapy (HRT) 0.8 1.0 2.6 -0.3 -1.4 -1.6 0.5 -0.2
Ever had hysterectomy (womb removed) 0.5 0.6 1.2 0.8 -0.1 1.1 0.2 1.1
Systolic blood pressure, automated reading 0.1 0.3 0.5 0.0 -0.2 -0.6 -0.7 -0.6
Eye problems/disorders: Diabetes related eye disease 0.6 0.6 1.8 -1.3 0.2 -0.9 -0.8 0.0
Angina 0.6 0.8 2.3 0.0 0.6 -0.4 1.0 1.5
Medication for hormone replacement therapy 1.1 1.2 2.4 1.1 0.7 0.9 1.1 1.5
Vitamin and mineral supplements 0.7 0.9 4.1 -0.2 0.2 -0.3 0.6 2.0
Supplements: Zinc 0.2 0.2 0.4 -0.3 0.3 -0.4 0.6 0.4
Medication: Co-codamol 0.3 0.3 1.1 -0.6 -1.0 -0.2 -0.0 0.0
Medication: Metformin 0.8 1.1 2.6 -0.5 0.3 -1.6 -0.4 1.6
Diabetes (father) 0.2 0.3 0.5 -0.5 -0.5 -0.6 -0.3 -0.7
Diabetes (mother) 0.1 0.1 0.3 0.1 -0.1 0.3 -0.6 0.5
Severe depression (siblings) 0.5 0.5 1.4 -1.2 -0.2 -1.0 0.0 -0.5
Pack years adult smoking proportion 0.1 0.2 0.5 0.2 0.6 -0.5 0.7 0.0
Impedance of leg (right) 0.1 0.6 2.6 0.6 0.5 1.6 0.2 -0.0
Leg fat-free mass (left) 0.5 2.6 9.8 -1.7 -0.4 -3.1 -0.3 -0.4
Trunk fat percentage 0.4 1.5 2.1 -1.3 -1.1 -1.3 0.8 -1.4
Hand grip strength (right) 0.3 0.7 1.3 -0.3 -1.1 -1.1 0.5 -0.8
Townsend deprivation index at recruitment 0.2 0.3 0.5 0.7 -0.5 0.4 0.6 0.6
Current tobacco smoking 2.4 3.9 8.1 -2.8 0.0 -2.8 -0.4 -1.9
Average weekly fortified wine intake 0.7 0.8 2.3 0.3 0.2 1.5 -0.5 -1.2
Maternal smoking around birth 0.8 1.2 4.6 -1.1 -0.0 -2.1 0.1 -0.1
Fed-up feelings 1.1 1.9 8.1 -0.6 2.8 -0.5 0.0 1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 3.3 -1.0 1.8 -0.3 0.5 0.0
Relative age voice broke 0.1 0.2 0.6 0.6 0.1 0.8 -0.3 -0.2
Taking other prescription medications 0.5 0.8 1.6 -0.2 1.2 0.9 1.0 0.9
Age when periods started (menarche) 0.1 0.1 0.4 -0.1 -0.4 0.2 0.7 0.1
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 2.1 0.5 -0.6 0.3 1.5 0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 2.3 0.2 1.5 1.0 -0.2 0.5
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 1.2 0.4 0.5 1.1 0.7 -1.0
Qualifications: CSEs or equivalent 0.7 0.9 4.0 0.0 0.1 0.5 2.0 -0.2
Serious illness, injury or assault to yourself 1.0 1.2 2.7 0.6 1.7 0.7 1.0 1.3
High blood pressure 0.4 1.1 2.7 -1.0 -0.3 -1.6 -1.1 -0.7
Hayfever, allergic rhinitis or eczema 0.7 1.4 4.0 -0.6 -2.0 -0.4 -1.2 -1.1
Multivitamins +/- minerals 0.9 1.2 4.0 0.4 0.1 0.7 -1.1 -2.0
Stomach or abdominal pain in last month 2.9 3.6 7.4 1.3 2.7 2.4 1.4 1.3
Supplements: Glucosamine 1.0 1.3 3.9 0.2 -1.1 -0.1 1.1 -2.0
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 1.3 0.8 -0.4 1.1 0.0 -1.1
Medication: Atenolol 1.6 2.0 4.2 -0.7 2.1 -0.6 -2.0 1.0
Medication: Levothyroxine sodium 0.7 1.2 3.1 -1.8 0.9 -0.0 -0.7 -1.2
Sitting height 0.1 1.0 4.3 0.4 0.4 -2.1 0.1 0.5
Chronic bronchitis/emphysema (father) 0.7 0.9 3.1 0.2 0.4 1.0 1.8 0.3
High blood pressure (mother) 0.2 0.3 0.9 -0.3 0.9 -0.2 -0.3 0.7
Body mass index (BMI) 0.6 2.7 5.9 -2.2 -0.6 -2.4 1.1 -0.9
Impedance of leg (left) 0.2 0.8 3.2 0.9 0.1 1.8 0.1 -0.2
Leg predicted mass (left) 0.5 2.5 9.5 -1.6 -0.4 -3.1 -0.4 -0.4
Trunk fat mass 0.4 1.8 4.1 -1.5 -0.9 -2.0 0.6 -1.3
Waist circumference 0.7 2.7 8.0 -2.1 -0.4 -2.8 0.8 -0.4
Number of incorrect matches in round 0.2 0.3 1.3 1.1 -0.3 0.3 0.0 -0.1
Past tobacco smoking 0.4 0.6 1.4 1.2 -0.3 0.7 0.2 1.1
Alcohol usually taken with meals 2.3 3.7 8.7 3.0 0.3 2.9 -0.3 1.1
Nervous feelings 0.8 1.5 2.8 1.5 1.7 1.2 0.8 0.9
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 2.3 -0.3 1.5 -0.4 0.1 0.6
Hearing difficulty/problems with background noise 1.4 2.2 3.5 1.9 1.4 1.2 1.2 1.7
Hair/balding pattern: Pattern 2 1.0 1.3 2.7 -1.6 0.3 -1.6 -0.8 0.8
Had menopause 2.1 2.7 5.9 2.4 0.0 1.9 1.5 1.3
Had other major operations 0.8 1.0 2.1 0.7 0.6 1.5 -0.6 1.3
Forced vital capacity (FVC) 0.1 0.2 0.8 -0.2 -0.1 0.4 -0.9 0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.2 0.5 -0.4 0.5 -0.1 -0.7 -0.4
Ever unenthusiastic/disinterested for a whole week 2.4 3.0 5.8 -1.9 1.1 -1.3 -2.4 -1.6
Qualifications: None of the above 0.4 0.9 2.2 0.3 1.4 -0.4 1.5 -0.0
Financial difficulties in last 2 years 0.5 0.7 1.8 -0.9 1.4 -0.7 -0.6 -0.2
Mouth/teeth dental problems 0.2 0.4 1.0 -0.0 0.6 0.3 -1.0 -0.7
Heart attack 0.5 0.6 1.3 -0.2 1.2 -0.0 -1.1 0.8
Allergy 0.3 0.6 1.4 0.2 1.2 -0.9 0.0 0.9
Pain all over the body in last month 0.1 0.1 0.3 0.1 -0.4 0.5 0.3 0.0
Diabetes (self-reported) 0.3 0.4 1.0 0.4 0.7 -0.6 0.2 1.0
Hayfever/allergic rhinitis (self-reported) 0.5 0.6 1.8 -0.1 1.0 0.3 0.6 1.3
Medication: Ramipril 1.1 1.4 2.1 -1.0 -0.9 -1.4 -1.2 1.2
Medication: Simvastatin 0.5 0.7 2.1 -0.6 0.7 -0.4 -1.4 -0.5
Fluid intelligence score 2.0 4.1 7.5 2.7 1.8 1.2 1.1 2.6
Illnesses of siblings 0.2 0.3 0.6 0.3 -0.8 0.8 0.1 0.6
Neuroticism score 0.1 0.2 1.0 -0.2 1.0 -0.3 0.4 0.0
Weight 0.6 3.0 9.6 -1.9 -0.7 -3.1 0.5 -0.9
Impedance of arm (right) 0.4 1.8 5.5 1.4 -0.6 2.3 -0.6 -0.9
Arm fat percentage (right) 0.4 1.6 2.9 -1.7 -0.8 -1.3 0.8 -1.5
Trunk fat-free mass 0.3 1.6 7.1 -0.9 0.3 -2.7 0.2 0.4
Hip circumference 0.7 3.1 8.2 -2.2 -1.0 -2.9 0.5 -1.1
Time employed in main current job 1.4 1.6 5.5 1.1 -0.1 -0.9 2.3 0.6
Alcohol intake versus 10 years previously 0.3 0.4 1.1 -0.0 0.2 -1.1 1.0 -0.0
Father’s age at death 2.3 3.1 5.1 2.3 2.0 1.6 0.9 1.8
Worrier / anxious feelings 0.1 0.2 0.6 -0.3 -0.2 -0.2 -0.3 -0.8
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.2 4.0 -0.9 1.1 -2.0 -0.3 0.3
Falls in the last year 0.6 0.9 3.0 0.2 0.5 0.8 -1.7 0.6
Hair/balding pattern: Pattern 3 0.7 1.0 2.5 1.6 0.4 1.3 0.2 0.8
Number of live births 0.6 0.9 2.9 0.6 1.0 0.1 0.2 1.7
Forced expiratory volume in 1-second (FEV1) 0.2 0.5 2.0 -0.3 -0.6 -0.4 -1.4 0.4
Pulse rate 0.5 0.8 1.7 -1.1 -0.6 -1.3 0.5 -0.6
Happiness 1.4 1.8 3.9 -1.4 0.4 -0.5 -2.0 -1.6
Noisy workplace 2.8 3.5 8.6 -1.8 -1.4 -2.9 1.0 -1.5
Qualifications: A levels/AS levels or equivalent 0.2 0.5 1.4 -0.1 -0.1 1.2 -0.9 -0.6
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 1.4 -0.8 -0.7 -0.6 -1.2 -1.0
Mouth/teeth dental problems: Dentures 2.4 4.0 7.9 2.8 -0.2 2.2 2.0 1.7
Asthma 1.9 3.8 13.0 0.8 1.0 3.6 2.0 0.6
Medication: Ibuprofen (e.g. Nurofen) 6.0 7.6 13.2 -3.6 -2.8 -2.3 -2.7 -2.0
Medication: Cholesterol lowering 1.3 2.0 5.2 -1.2 -1.0 -1.6 -2.3 -0.1
Depression (self-reported) 1.1 1.3 2.0 1.2 0.6 1.0 1.3 1.4
Medication: Lansoprazole 0.2 0.3 0.5 -0.4 0.1 -0.7 0.7 -0.4
Prospective memory result 0.6 0.7 2.5 0.6 -0.8 1.6 -0.3 0.2
Lung cancer (father) 1.3 1.5 2.6 -1.6 -1.1 -1.4 -0.8 -1.1
Illnesses of mother 0.8 0.9 1.6 1.1 -0.3 1.2 1.3 -0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 1.6 -0.0 -1.0 -0.7 -1.2 0.5
Pulse wave Arterial Stiffness index 0.8 1.0 2.0 0.0 -1.4 -1.1 -0.1 -1.3
Impedance of arm (left) 0.3 1.6 5.0 1.2 -0.5 2.2 -1.1 -0.3
Arm fat mass (right) 0.5 2.2 5.4 -2.0 -0.5 -2.3 0.6 -1.0
Trunk predicted mass 0.3 1.5 6.4 -0.8 0.3 -2.5 0.3 0.5
Standing height 0.1 0.9 2.8 0.6 -0.0 -1.7 -1.1 0.4
Length of working week for main job 0.8 0.9 3.2 -0.4 -0.4 0.1 -1.0 -1.8
Exposure to tobacco smoke at home 0.6 0.7 2.5 0.2 1.6 0.3 0.2 0.8
Breastfed as a baby 1.4 1.7 2.9 0.6 1.7 1.4 -1.7 0.7
Tense / ‘highly strung’ 0.1 0.2 0.5 0.4 -0.7 0.1 -0.3 -0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 0.9 -0.9 -0.0 -0.5 0.5 -0.1
Hair/balding pattern: Pattern 4 0.1 0.4 0.7 -0.3 -0.8 -0.6 0.2 -0.9
Birth weight of first child 0.5 1.0 2.6 1.1 0.9 0.5 1.6 -0.0
Peak expiratory flow (PEF) 0.5 1.1 3.9 -0.7 0.5 -0.9 -2.0 0.3
Pulse wave reflection index 0.8 1.0 3.5 1.9 -0.9 0.2 0.4 0.7
Ever highly irritable/argumentative for 2 days 2.8 3.3 6.7 -2.6 -0.1 -1.6 -2.1 -1.8
Loud music exposure frequency 0.2 0.2 0.7 0.5 0.3 0.8 0.1 0.3
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.9 0.0 -0.6 0.9 -0.2 0.0
Mouth/teeth dental problems: Bleeding gums 2.5 3.3 6.5 -1.9 -2.5 -2.2 -0.7 -1.0
Blood clot in the leg (DVT) 0.8 1.0 4.3 -0.2 -0.7 0.4 -0.0 -2.1
Medication: Paracetamol 0.8 1.4 1.7 -1.3 -1.2 -1.0 -1.0 -1.3
Headache pain in last month 0.8 1.3 3.8 0.5 0.6 1.0 1.9 1.1
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 1.6 0.7 0.4 1.3 0.9 -0.6
Glaucoma (self-reported) 0.8 1.0 2.8 0.3 -1.7 -0.6 1.2 -0.2
Gout (self-reported) 0.1 0.2 0.6 -0.4 -0.0 -0.0 -0.5 -0.7
Hypothyroidism/myxoedema (self-reported) 0.5 0.9 2.9 -0.5 1.7 0.7 0.6 0.8
Medication: Amlodipine 1.8 2.6 5.8 -2.2 1.1 -1.1 -2.4 -0.1
Medication: Ventolin 100micrograms inhaler 3.2 4.1 10.5 0.8 1.4 2.2 3.2 1.6
Birth weight 0.9 1.9 5.6 -1.6 -0.4 -2.4 -1.0 -0.1
Chronic bronchitis/emphysema (mother) 0.5 0.6 1.5 -0.0 1.0 1.2 0.8 0.2
High blood pressure (siblings) 0.4 0.5 1.7 -0.6 0.2 -0.6 -1.3 -0.5
Forced vital capacity (FVC), Best measure 0.1 0.3 0.7 -0.2 -0.4 -0.7 -0.3 0.8
Body fat percentage 0.4 1.5 2.5 -1.6 -0.9 -1.3 0.9 -1.4
Leg fat percentage (right) 0.4 1.5 2.6 -1.6 -0.2 -1.1 1.5 -1.1
Arm fat-free mass (right) 0.5 2.6 10.9 -1.4 -0.3 -3.3 0.1 0.2
Exposure to tobacco smoke outside home 0.6 0.7 1.4 -0.8 -1.0 -0.6 1.2 -0.6
Comparative body size at age 10 0.2 0.5 0.9 -0.5 -0.3 0.6 0.9 -0.9
Number of full brothers 0.3 0.4 1.1 -0.7 -0.0 -1.1 -0.1 0.7
Worry too long after embarrassment 0.1 0.1 0.5 -0.2 -0.1 -0.4 0.2 -0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.2 0.8 -0.9 0.0 -0.2 0.2 0.4
Wheeze or whistling in the chest in last year 1.2 2.1 4.0 0.4 1.6 1.9 2.0 -0.1
Number of children fathered 0.5 0.6 1.9 -0.6 0.1 -1.4 0.7 -0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.8 1.0 3.5 0.0 -1.9 -0.1 1.2 -0.1
Age at first live birth 0.6 1.0 2.4 1.5 1.1 0.9 -0.4 0.7
Pulse wave peak to peak time 0.9 1.0 2.0 0.2 1.4 1.1 0.0 1.4
Health satisfaction 0.9 1.2 2.6 -1.2 0.1 -0.9 -1.0 -1.6
Shortness of breath walking on level ground 1.6 1.9 4.5 -2.1 0.0 -1.4 -0.9 -1.5
Qualifications: College or University degree 0.2 0.7 2.8 0.2 0.3 0.7 -1.7 -0.5
Eye problems/disorders: None of the above 0.5 0.6 2.1 0.5 0.7 1.5 0.3 0.3
Mouth/teeth dental problems: Loose teeth 0.6 0.7 2.0 0.4 -1.1 1.4 0.3 0.4
Emphysema/chronic bronchitis 0.5 0.5 1.3 -1.1 0.2 0.1 1.1 0.3
Medication for pain relief, constipation, heartburn 0.3 0.6 1.2 1.1 0.2 0.9 0.9 0.2
Neck or shoulder pain in last month 0.5 0.8 1.5 -0.6 1.2 0.6 -0.3 -1.2
Medication: Blood pressure 0.2 0.4 0.8 -0.8 -0.0 -0.9 -0.6 0.5
Angina (self-reported) 0.5 0.6 2.0 0.1 0.6 -0.4 0.8 1.4
Migraine (self-reported) 0.4 0.5 1.3 0.8 -0.0 1.1 -0.2 0.9
Medication: Ibuprofen 5.5 6.6 11.0 -3.3 -2.4 -2.6 -2.2 -2.2
Medication: Allopurinol 0.3 0.3 0.7 0.9 0.5 0.8 -0.1 0.0
Medication: Omeprazole 0.2 0.3 1.2 -0.1 1.1 -0.0 0.4 0.1
Medication: Seretide 50 evohaler 0.5 0.5 1.4 -0.2 0.9 1.2 0.6 0.2
Mean time to correctly identify matches 0.3 0.6 1.7 -0.1 1.3 0.1 -0.9 -0.7
Heart disease (mother) 0.7 0.9 2.1 -0.3 -0.1 -1.4 -0.3 1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 0.9 1.6 -1.2 0.0 0.5 -1.2 -1.2
Whole body fat mass 0.5 2.2 5.3 -1.9 -0.7 -2.3 0.5 -1.2
Leg fat mass (right) 0.7 2.6 6.1 -2.1 -0.6 -2.5 1.0 -1.1
Arm predicted mass (right) 0.6 3.0 12.4 -1.6 0.2 -3.5 -0.2 0.3
Pulse rate, automated reading 0.1 0.2 0.8 0.1 0.4 0.3 0.9 -0.1
Alcohol intake frequency. 0.2 0.4 1.3 0.5 0.6 -0.3 1.1 -0.3
Comparative height size at age 10 0.1 0.4 0.9 0.3 0.6 -0.9 -0.4 0.8
Number of full sisters 0.6 0.7 1.4 -1.2 -0.3 -0.9 0.7 -0.8
Suffer from ‘nerves’ 0.1 0.1 0.5 -0.2 0.7 -0.3 0.1 0.3
Overall health rating 0.5 1.2 2.4 -1.4 1.0 -1.6 -0.5 0.3
Chest pain or discomfort 1.2 1.8 4.4 -1.5 2.1 -0.3 1.5 0.3
Had major operations 1.2 1.4 2.6 1.0 -1.4 -0.0 1.6 -1.2
Age at last live birth 0.6 0.9 3.1 0.5 1.8 -0.3 -0.1 1.0
Family relationship satisfaction 0.9 1.1 2.8 -0.4 -0.1 0.3 -1.6 -1.7
Leg pain on walking 0.2 0.3 0.6 -0.8 0.1 -0.0 -0.5 -0.7
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 1.1 1.1 -0.4 -0.5 1.0 1.0
Commuting to job workplace: Car/motor vehicle 0.8 0.9 2.3 1.5 -0.6 1.0 0.4 0.8
Illness, injury, bereavement, stress in last 2 years 0.6 0.8 1.3 1.0 -0.3 0.8 1.1 0.8
Medication: Aspirin 0.3 0.4 0.7 -0.6 0.9 -0.7 -0.1 0.5
Supplements: Vitamin C 0.7 0.9 2.9 -0.1 -1.7 -0.9 0.0 -0.8
Knee pain experienced in last month 0.6 0.9 2.4 -1.2 -0.3 -0.0 -0.9 -1.5
Hypertension (Self-reported) 0.4 1.2 3.8 -1.0 0.0 -1.9 -1.1 -0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 2.0 0.3 1.1 -0.3 -1.1 1.4
Illnesses of father: Heart disease 1.9 2.6 3.7 1.6 1.9 1.9 0.1 1.8
Illnesses of siblings: Diabetes 1.7 2.1 3.3 1.8 0.9 1.0 1.8 1.4
Smoking status: Previous 0.4 0.6 1.4 0.7 1.0 1.2 0.4 0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.5 2.0 0.6 0.3 -0.2 -0.3 1.4
Whole body fat-free mass 0.4 2.3 9.7 -1.4 0.1 -3.1 -0.2 0.1
Leg fat-free mass (right) 0.5 2.6 9.5 -1.6 -0.5 -3.1 -0.6 -0.5
Arm fat percentage (left) 0.4 1.7 3.5 -1.9 -0.8 -1.5 0.6 -1.3
Average weekly red wine intake 1.0 1.4 2.3 1.5 0.0 1.3 -1.3 1.2
Handedness (chirality/laterality): Left-handed 1.1 1.3 2.2 -0.9 -1.4 -0.3 1.2 -1.5
Mood swings 0.6 1.1 4.2 -0.9 2.1 -0.3 -0.2 0.5
Loneliness, isolation 1.1 1.5 4.0 -1.6 0.3 -2.0 0.8 -0.4
Long-standing illness, disability or infirmity 0.5 0.8 3.2 -0.7 1.8 0.1 -0.1 0.1
Ever had bowel cancer screening 0.2 0.3 0.7 0.2 -0.3 -0.7 0.9 0.2
Diabetes diagnosed by doctor 0.4 0.6 1.3 -0.9 0.2 -1.1 -0.9 0.2
Ever had stillbirth, spontaneous miscarriage or termination 2.2 2.3 7.6 -1.9 0.2 -2.8 0.6 -0.0
Friendships satisfaction 0.4 0.5 1.1 -0.6 0.5 0.4 -1.1 -0.8
Qualifications: nursing, teaching 0.8 1.3 4.6 -0.3 -0.2 1.2 -2.1 0.5
Commuting to job workplace: Walk 0.2 0.2 1.0 0.0 0.2 1.0 -0.1 0.0
Eye problems/disorders: Cataract 0.2 0.2 0.6 0.4 0.6 0.1 -0.8 0.1
Mouth/teeth dental problems: Mouth ulcers 1.2 1.9 5.2 -2.3 0.5 -1.2 -0.8 -1.3
Medication for cholesterol 1.0 1.5 4.4 1.0 -0.6 2.1 1.1 -0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 1.0 2.8 -0.8 -0.7 -1.7 0.9 -0.3
Back pain experienced in last month 0.4 0.6 1.0 0.9 0.6 0.8 -0.0 1.0
Mineral and other dietary supplements 1.0 1.4 4.6 0.1 0.9 -0.3 1.2 2.1
Breast cancer (self-reported) 1.2 1.4 4.1 0.1 1.2 1.3 -2.0 0.2
Asthma (self-reported) 2.0 3.9 13.0 0.8 0.7 3.6 2.3 0.6
Osteoporosis (self-reported) 1.0 1.2 2.3 -1.5 -0.4 -1.2 -1.3 -0.8
Osteoarthritis (self-reported) 0.9 1.1 2.2 -1.5 0.9 -0.4 -0.8 -1.4
Medication: Aspirin 0.6 0.7 2.3 -0.5 1.5 -0.7 -0.0 0.8
Medication: Gliclazide 0.5 0.6 1.6 -0.7 -0.4 -0.7 -1.3 -0.6
Illnesses of father: None of the above (group 1) 1.4 1.7 2.2 -1.1 -1.5 -0.8 -1.5 -1.4
Smoking status: Current 2.8 4.5 8.9 -2.9 0.1 -3.0 -0.5 -2.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 3.0 1.0 -1.7 0.6 0.2 -0.1
Whole body water mass 0.4 2.3 9.6 -1.4 -0.0 -3.1 -0.3 0.1
Leg predicted mass (right) 0.5 2.5 9.7 -1.5 -0.5 -3.1 -0.5 -0.4
Arm fat mass (left) 0.6 2.4 5.6 -2.0 -0.9 -2.4 0.5 -1.0
Number of self-reported non-cancer illnesses 0.1 0.2 0.5 0.1 0.7 0.0 0.4 0.2
Average weekly champagne plus white wine intake 0.3 0.5 1.2 0.2 -0.1 -0.2 -1.0 1.1
Miserableness 0.5 0.9 2.8 -0.4 1.7 -0.3 1.2 0.4
Guilty feelings 0.1 0.1 0.5 -0.0 0.1 -0.7 -0.0 -0.0
Wears glasses or contact lenses 0.9 1.1 2.6 1.4 0.5 1.6 0.6 0.6
Ever taken oral contraceptive pill 1.8 2.0 3.8 -1.9 -0.4 -1.7 -1.9 -0.2
Hearing aid user 1.3 1.4 2.7 -1.6 1.0 -1.6 0.6 -0.8
Mother’s age at death 0.5 0.6 2.5 0.3 -1.6 0.5 0.6 0.0
Financial situation satisfaction 0.5 0.7 1.8 -1.3 0.3 -0.7 -0.6 -0.7
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.3 0.3 -0.1 0.1 -0.5 -0.4
Commuting to job workplace: Public transport 0.3 0.3 0.8 -0.9 0.5 -0.5 -0.6 -0.3
Eye problems/disorders: Glaucoma 0.6 0.7 3.1 -0.3 -1.8 -0.6 0.3 -0.1
Medication: Blood pressure 0.9 1.8 5.5 -0.6 -0.5 -2.4 -1.7 0.3
Pain type(s) experienced in last month: Hip pain 0.8 1.0 3.3 -1.2 -0.1 -0.5 -1.8 0.1
Supplements: Fish oil (including cod liver oil) 1.5 1.9 3.6 0.8 -1.9 1.2 -1.3 -1.5
High cholesterol (Self-reported) 0.8 1.5 3.4 -1.4 -0.4 -1.1 -1.9 -0.9
Medication: Bendroflumethiazide 0.6 0.9 3.4 0.8 -0.4 -0.7 0.0 1.9
Medication: Paracetamol 0.6 0.9 1.3 -0.8 -0.9 -0.5 -1.1 -1.2
Medication: Lisinopril 0.4 0.5 2.1 0.2 -1.4 0.2 -0.5 0.1
Medication: Atorvastatin 1.2 1.5 3.6 -0.8 1.9 -1.1 -0.5 1.3
Illnesses of father: High blood pressure 0.6 0.8 2.3 -0.2 -0.7 -0.8 1.5 0.4
Alcohol drinker status: Never 3.5 4.2 6.0 2.2 2.4 2.0 0.4 2.5
Ever smoked 0.8 1.5 2.7 -1.6 -0.5 -1.4 -0.1 -1.6
Basal metabolic rate 0.5 2.6 10.2 -1.7 -0.1 -3.2 -0.1 -0.2
Leg fat percentage (left) 0.4 1.4 2.8 -1.2 -0.4 -1.0 1.7 -1.2
Arm fat-free mass (left) 0.5 2.4 9.6 -1.4 -0.2 -3.1 0.3 0.1
Number of operations (self-reported) 0.1 0.2 0.8 -0.1 -0.5 0.2 -0.0 -0.9
Average weekly beer plus cider intake 0.3 0.5 0.9 0.1 0.9 -0.9 0.9 0.3
Irritability 0.8 1.3 2.6 1.6 1.6 0.5 0.6 0.8
Risk taking 0.8 1.1 2.3 -0.8 -1.5 -1.1 -0.4 -1.2
Ever had prostate specific antigen (PSA) test 0.5 0.6 2.4 -0.7 0.1 -0.3 -1.6 -0.3
Fractured/broken bones in last 5 years 0.4 0.5 1.8 -1.3 -0.1 -0.5 0.1 0.5
Age started oral contraceptive pill 0.5 0.6 1.3 1.1 0.4 1.1 0.3 -0.5
Diastolic blood pressure, automated reading 0.2 0.7 2.3 0.4 -0.3 -1.5 -0.6 -0.7
Ever depressed for a whole week 0.4 0.5 0.9 -1.0 0.0 -0.6 -0.7 -0.7
Unable to work because of sickness or disability 1.7 2.2 4.9 1.1 2.2 1.4 0.9 1.4
Commuting to job workplace: Cycle 0.1 0.1 0.3 0.1 -0.1 -0.4 -0.6 -0.4
Myopia 1.1 1.6 2.9 1.4 -0.6 1.6 1.7 0.6
Vascular/heart problems diagnosed by doctor 0.5 1.3 3.4 1.1 0.5 1.9 1.1 0.3
Cholesterol lowering medication 0.9 1.3 1.8 -1.3 1.0 -1.1 -1.0 -1.4
Medication: Omeprazole (e.g. Zanprol) 0.7 0.8 2.6 0.7 1.6 0.8 0.3 0.4
Pain experienced in last month 0.4 0.7 2.1 0.4 -1.4 -0.8 0.9 0.1
Supplements: Calcium 2.3 2.6 5.4 -1.0 -1.8 -1.7 -0.6 -2.3
Basal cell carcinoma (self-reported) 1.2 1.4 5.4 -0.0 -0.2 -0.9 -2.3 -0.8
Heart attack/myocardial infarction (self-reported) 0.5 0.7 1.4 0.0 1.2 -0.0 -0.8 1.2
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 3.7 -0.3 -1.1 0.4 0.1 -1.9
Heart disease (siblings) 0.5 0.6 1.4 0.3 -0.3 -1.1 1.2 0.2
Alcohol drinker status: Previous 2.4 2.8 4.7 2.1 1.2 1.6 2.2 0.8
Pack years of smoking 0.3 0.4 1.6 0.5 0.5 -0.3 1.3 -0.1
Impedance of whole body 0.4 1.8 6.4 1.4 -0.1 2.5 -0.7 0.0
Leg fat mass (left) 0.6 2.5 6.1 -1.9 -0.7 -2.5 1.1 -1.1
Arm predicted mass (left) 0.5 2.6 10.4 -1.7 -0.1 -3.2 0.1 -0.0