Best TWAS P=4.17e-11 · Best GWAS P=4.12e-14 conditioned to 5.25e-05
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | IFT172 | 0.06 | 0.09 | enet | 16 | 0.09 | 3.9e-11 | 3.9 | 5.5 | 3.7e-08 | -0.78 | 0.37 | 0.63 | FALSE |
2 | GTEx | Adipose Subcutaneous | AC074117.10 | 0.06 | 0.04 | lasso | 5 | 0.02 | 4.8e-03 | 5.4 | -5.1 | 2.8e-07 | 0.66 | 0.57 | 0.08 | FALSE |
3 | GTEx | Cells Transformed fibroblasts | AC074117.10 | 0.21 | 0.19 | enet | 23 | 0.18 | 1.6e-13 | 5.4 | -5.1 | 2.9e-07 | 0.65 | 1.00 | 0.00 | FALSE |
4 | GTEx | Esophagus Mucosa | AC074117.10 | 0.12 | 0.14 | lasso | 8 | 0.14 | 2.1e-09 | 5.4 | -5.5 | 3.0e-08 | 0.74 | 0.91 | 0.09 | FALSE |
5 | GTEx | Esophagus Muscularis | NRBP1 | 0.07 | 0.04 | lasso | 6 | 0.04 | 1.3e-03 | 5.4 | -6.0 | 1.7e-09 | 0.81 | 0.08 | 0.86 | FALSE |
6 | GTEx | Esophagus Muscularis | AC074117.10 | 0.17 | 0.14 | enet | 5 | 0.09 | 6.6e-06 | 5.4 | -5.2 | 1.7e-07 | 0.66 | 0.92 | 0.06 | FALSE |
7 | GTEx | Ovary | AC074117.10 | 0.16 | 0.04 | enet | 9 | 0.05 | 2.0e-02 | 3.8 | -5.6 | 2.6e-08 | 0.79 | 0.06 | 0.67 | FALSE |
8 | GTEx | Testis | NRBP1 | 0.16 | 0.09 | lasso | 3 | 0.06 | 1.8e-03 | 5.4 | -6.5 | 7.3e-11 | 0.82 | 0.02 | 0.96 | FALSE |
9 | GTEx | Testis | AC074117.10 | 0.14 | 0.08 | lasso | 6 | 0.12 | 4.5e-06 | 4.3 | -6.4 | 1.9e-10 | 0.88 | 0.03 | 0.97 | FALSE |
10 | GTEx | Vagina | AC074117.10 | 0.14 | 0.04 | enet | 13 | 0.06 | 1.4e-02 | 4.2 | -5.2 | 2.0e-07 | 0.74 | 0.12 | 0.36 | FALSE |
11 | METSIM | Adipose | NRBP1 | 0.06 | 0.09 | lasso | 3 | 0.08 | 1.6e-12 | 5.4 | -5.5 | 3.9e-08 | 0.68 | 0.99 | 0.01 | FALSE |
12 | ROSMAP | Brain Pre-frontal Cortex | IFT172 | 0.07 | 0.02 | blup | 287 | 0.03 | 5.8e-05 | 4.1 | 5.5 | 5.0e-08 | -0.66 | 0.42 | 0.50 | FALSE |
13 | ROSMAP | Brain Pre-frontal Cortex | FTH1P3 | 0.04 | 0.01 | bslmm | 280 | 0.02 | 2.8e-03 | 5.4 | -5.7 | 1.4e-08 | 0.67 | 0.04 | 0.73 | FALSE |
14 | The Cancer Genome Atlas | Breast Invasive Carcinoma | GPN1 | 0.06 | 0.02 | lasso | 6 | 0.02 | 7.2e-05 | -5.8 | -5.7 | 9.9e-09 | 0.57 | 0.00 | 0.98 | FALSE |
15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SNX17 | 0.08 | 0.01 | blup | 25 | 0.02 | 6.6e-05 | 3.1 | 5.8 | 8.8e-09 | -0.52 | 0.00 | 0.78 | FALSE |
16 | The Cancer Genome Atlas | Glioblastoma Multiforme | NRBP1 | 0.15 | 0.10 | lasso | 2 | 0.10 | 5.8e-04 | 5.4 | -5.4 | 6.7e-08 | 0.67 | 0.00 | 0.72 | FALSE |
17 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | FNDC4 | 0.13 | 0.06 | lasso | 2 | 0.05 | 1.1e-03 | -6.7 | 6.6 | 4.2e-11 | -0.95 | 0.00 | 0.91 | TRUE |