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chr3:155,544,380-157,226,796

Best TWAS P=5.4e-18 · Best GWAS P=5.02e-29 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	LINC00886	0.42	0.24	enet	28	0.38	1.7e-32	6.7	6.0	2.5e-09	-0.64	1.00	0.00	FALSE
2	GTEx	Artery Aorta	LINC00886	0.40	0.24	lasso	9	0.22	2.7e-12	6.7	7.0	1.8e-12	-0.78	0.79	0.21	FALSE
3	GTEx	Breast Mammary Tissue (Male)	LINC00886	0.17	0.03	enet	4	0.04	4.4e-02	6.7	6.2	7.0e-10	-0.67	0.04	0.43	FALSE
4	GTEx	Cells Transformed fibroblasts	SSR3	0.08	0.01	lasso	6	0.02	2.1e-02	5.9	-6.7	2.4e-11	0.51	0.23	0.07	FALSE
5	GTEx	Colon Sigmoid	LINC00886	0.58	0.28	enet	26	0.40	1.7e-15	3.5	5.4	6.3e-08	-0.60	0.73	0.26	FALSE
6	GTEx	Colon Transverse	METTL15P1	0.26	0.00	lasso	5	-0.01	7.8e-01	4.1	5.4	5.7e-08	-0.59	0.04	0.27	TRUE
7	GTEx	Colon Transverse	LINC00886	0.41	0.24	lasso	14	0.24	1.7e-11	6.7	6.4	2.2e-10	-0.74	0.95	0.05	TRUE
8	GTEx	Esophagus Gastroesophageal Junction	LINC00886	0.40	0.31	enet	25	0.34	4.8e-13	5.7	5.6	2.4e-08	-0.70	0.93	0.07	FALSE
9	GTEx	Esophagus Muscularis	METTL15P1	0.10	0.03	lasso	2	0.02	1.8e-02	6.1	6.9	6.4e-12	-0.73	0.42	0.27	FALSE
10	GTEx	Esophagus Muscularis	LINC00886	0.46	0.29	lasso	6	0.43	4.1e-28	6.7	5.3	1.0e-07	-0.69	0.90	0.10	FALSE
11	GTEx	Heart Atrial Appendage	LINC00886	0.33	0.04	lasso	11	0.03	2.0e-02	3.0	5.7	1.6e-08	-0.64	0.16	0.69	FALSE
12	GTEx	Heart Atrial Appendage	RP11-305K5.1	0.16	0.05	lasso	3	0.05	2.6e-03	5.0	-6.7	1.9e-11	0.29	0.24	0.07	TRUE
13	GTEx	Heart Left Ventricle	LINC00886	0.25	0.08	lasso	10	0.07	1.5e-04	6.9	6.6	3.4e-11	-0.78	0.28	0.45	TRUE
14	GTEx	Lung	LINC00886	0.19	0.07	enet	21	0.13	2.5e-10	6.7	5.5	4.1e-08	-0.63	0.68	0.32	FALSE
15	GTEx	Muscle Skeletal	LINC00886	0.23	0.10	enet	29	0.14	1.9e-13	6.7	6.7	1.6e-11	-0.66	0.64	0.36	TRUE
16	GTEx	Nerve Tibial	SSR3	0.21	0.01	enet	42	0.07	1.5e-05	2.9	-5.5	3.3e-08	0.23	0.33	0.14	TRUE
17	GTEx	Nerve Tibial	LINC00886	0.30	0.14	lasso	16	0.16	8.4e-12	6.7	6.0	1.5e-09	-0.72	0.73	0.27	FALSE
18	GTEx	Pancreas	LINC00886	0.32	0.23	enet	25	0.26	3.1e-11	6.7	5.8	6.0e-09	-0.71	0.66	0.33	FALSE
19	GTEx	Prostate	LINC00886	0.40	0.18	lasso	13	0.16	8.0e-05	3.0	5.1	2.7e-07	-0.61	0.10	0.43	TRUE
20	GTEx	Testis	LINC00886	0.39	0.24	lasso	9	0.21	1.5e-09	6.7	6.7	2.1e-11	-0.82	0.85	0.15	TRUE
21	GTEx	Uterus	LINC00886	0.30	0.13	lasso	5	0.14	1.1e-03	6.7	6.4	2.1e-10	-0.77	0.04	0.50	FALSE
22	GTEx	Whole Blood	LINC00886	0.19	0.05	lasso	10	0.08	3.7e-08	6.7	5.6	2.7e-08	-0.68	0.47	0.52	FALSE
23	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	LEKR1	0.10	0.14	lasso	6	0.12	1.8e-10	5.1	-5.1	2.7e-07	0.47	1.00	0.00	FALSE
24	The Cancer Genome Atlas	Breast Invasive Carcinoma	LOC100287227	0.05	0.01	blup	47	0.02	1.7e-04	7.9	-8.6	5.4e-18	0.42	0.01	0.84	TRUE
25	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	LEKR1	0.18	0.12	enet	8	0.10	9.2e-06	5.1	-5.4	5.2e-08	0.45	0.94	0.02	FALSE
26	The Cancer Genome Atlas	Esophageal Carcinoma	LOC100287227	0.14	0.04	lasso	5	0.02	5.7e-02	6.4	-6.9	4.4e-12	0.52	0.02	0.36	FALSE
27	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	LEKR1	0.09	0.10	lasso	3	0.09	4.4e-10	5.1	-5.4	7.5e-08	0.46	1.00	0.00	FALSE
28	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LEKR1	0.22	0.18	enet	21	0.22	2.1e-24	6.2	-7.2	8.0e-13	0.48	1.00	0.00	TRUE
29	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	LEKR1	0.16	0.13	lasso	5	0.13	8.4e-08	5.1	-5.4	7.3e-08	0.44	1.00	0.00	TRUE
30	The Cancer Genome Atlas	Brain Lower Grade Glioma	SSR3	0.06	0.04	lasso	5	0.03	4.9e-04	-6.5	-6.0	2.6e-09	0.21	0.00	1.00	FALSE
31	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LEKR1	0.12	0.07	blup	114	0.08	2.6e-09	6.1	-6.0	2.1e-09	0.51	1.00	0.00	FALSE
32	The Cancer Genome Atlas	Prostate Adenocarcinoma	LEKR1	0.20	0.19	lasso	5	0.19	2.6e-19	5.1	-5.2	2.4e-07	0.47	1.00	0.00	FALSE
33	The Cancer Genome Atlas	Prostate Adenocarcinoma	SSR3	0.04	0.04	enet	3	0.03	4.2e-04	5.2	-5.3	1.1e-07	0.16	0.07	0.89	FALSE
34	The Cancer Genome Atlas	Rectum Adenocarcinoma	LEKR1	0.40	0.25	lasso	2	0.26	9.1e-07	6.1	-6.1	9.4e-10	0.42	0.34	0.06	TRUE
35	The Cancer Genome Atlas	Soft Tissue Sarcoma	LEKR1	0.15	0.04	lasso	6	0.09	6.9e-06	5.1	-6.8	1.0e-11	0.49	0.96	0.01	FALSE
36	The Cancer Genome Atlas	Stomach Adenocarcinoma	LEKR1	0.06	0.07	lasso	3	0.07	1.1e-05	6.1	-6.8	1.2e-11	0.56	0.74	0.04	FALSE
37	The Cancer Genome Atlas	Testicular Germ Cell Tumors	LEKR1	0.12	0.03	blup	114	0.03	2.5e-02	6.1	-6.2	6.2e-10	0.60	0.04	0.08	FALSE
38	The Cancer Genome Atlas	Thyroid Carcinoma	LEKR1	0.24	0.33	lasso	8	0.37	9.5e-38	6.1	-6.1	8.5e-10	0.49	1.00	0.00	FALSE