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chr11:87,146,898-90,616,949

Best TWAS P=1.2e-38 · Best GWAS P=0 conditioned to 0

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CTSC	0.14	0.05	lasso	4	0.08	3.9e-10	-8.61	7.6	2.5e-14	-0.19	1.00	0.00	TRUE
2	CommonMind	Brain Pre-frontal Cortex	NAALAD2	0.18	0.13	enet	13	0.16	1.3e-19	10.17	-9.6	5.8e-22	0.11	1.00	0.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	NOX4	0.26	0.16	blup	254	0.23	7.0e-28	-12.52	-5.8	5.0e-09	0.19	1.00	0.00	FALSE
4	GTEx	Adipose Subcutaneous	CTSC	0.18	0.00	lasso	6	0.00	2.6e-01	1.37	5.9	3.1e-09	-0.14	0.08	0.03	FALSE
5	GTEx	Adrenal Gland	NAALAD2	0.26	0.19	lasso	8	0.19	1.8e-07	10.99	11.2	3.9e-29	-0.11	0.87	0.01	FALSE
6	GTEx	Cells Transformed fibroblasts	NAALAD2	0.28	0.18	lasso	6	0.23	1.7e-17	11.01	10.0	1.8e-23	-0.11	1.00	0.00	TRUE
7	GTEx	Esophagus Mucosa	NAALAD2	0.17	0.10	enet	17	0.09	1.3e-06	11.08	5.7	1.5e-08	-0.06	0.97	0.00	TRUE
8	GTEx	Esophagus Muscularis	NAALAD2	0.33	0.06	lasso	6	0.07	6.7e-05	10.99	8.7	3.1e-18	-0.13	0.64	0.03	FALSE
9	GTEx	Heart Atrial Appendage	NAALAD2	0.17	0.10	enet	10	0.09	1.1e-04	11.05	10.8	5.0e-27	-0.13	0.44	0.03	FALSE
10	GTEx	Lung	NAALAD2	0.29	0.12	enet	28	0.13	2.1e-10	10.99	5.6	2.4e-08	-0.06	1.00	0.00	TRUE
11	GTEx	Pituitary	NAALAD2	0.46	0.30	lasso	5	0.26	2.7e-07	11.05	10.7	7.1e-27	-0.12	0.86	0.02	FALSE
12	GTEx	Testis	NAALAD2	0.11	0.03	lasso	5	0.01	1.1e-01	10.99	11.3	1.5e-29	-0.11	0.24	0.04	TRUE
13	NTR	Blood	CTSC	0.13	0.08	bslmm	579	0.13	6.2e-41	13.53	-6.0	2.5e-09	-0.09	1.00	0.00	TRUE
14	NTR	Blood	RAB38	0.02	0.00	bslmm	561	0.01	3.3e-05	2.98	6.3	3.2e-10	-0.05	0.32	0.03	TRUE
15	ROSMAP	Brain Pre-frontal Cortex	NAALAD2	0.26	0.10	bslmm	280	0.19	2.2e-23	10.01	-12.2	2.1e-34	0.17	1.00	0.00	FALSE
16	YFS	Blood	CTSC	0.36	0.26	enet	50	0.37	1.1e-128	13.53	-8.2	2.7e-16	-0.01	1.00	0.00	TRUE
17	The Cancer Genome Atlas	Breast Invasive Carcinoma	CHORDC1	0.07	0.00	enet	14	0.01	1.4e-03	5.47	-5.2	2.4e-07	0.12	0.00	0.23	FALSE
18	The Cancer Genome Atlas	Breast Invasive Carcinoma	CTSC	0.02	0.01	enet	7	0.01	3.7e-03	-8.38	9.2	3.7e-20	-0.20	0.25	0.08	TRUE
19	The Cancer Genome Atlas	Breast Invasive Carcinoma	NAALAD2	0.04	0.02	lasso	5	0.03	1.1e-06	6.45	7.6	3.9e-14	-0.03	0.04	0.92	FALSE
20	The Cancer Genome Atlas	Breast Invasive Carcinoma	NOX4	0.02	0.00	blup	98	0.01	1.6e-03	-7.38	13.0	1.2e-38	-0.31	0.11	0.02	TRUE
21	The Cancer Genome Atlas	Colon Adenocarcinoma	CTSC	0.13	0.06	blup	73	0.06	2.3e-04	-6.32	7.8	9.3e-15	-0.14	0.15	0.05	TRUE
22	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CTSC	0.07	0.01	blup	73	0.03	2.9e-04	0.97	8.7	2.8e-18	-0.22	0.14	0.02	FALSE
23	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NAALAD2	0.15	0.10	blup	58	0.09	1.3e-10	6.45	7.5	5.7e-14	-0.04	0.90	0.10	FALSE
24	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	NAALAD2	0.03	0.02	lasso	3	0.01	3.0e-02	11.08	11.0	4.1e-28	-0.13	0.01	0.77	FALSE
25	The Cancer Genome Atlas	Prostate Adenocarcinoma	CTSC	0.08	0.02	blup	72	0.04	5.6e-05	0.97	5.7	1.3e-08	-0.19	0.07	0.03	FALSE
26	The Cancer Genome Atlas	Prostate Adenocarcinoma	NAALAD2	0.06	0.06	blup	58	0.07	9.4e-08	5.87	11.3	7.5e-30	-0.08	0.03	0.97	FALSE
27	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CTSC	0.12	0.01	blup	72	0.05	8.3e-03	11.77	11.2	5.9e-29	-0.21	0.05	0.24	TRUE