Hub : Genes

CHORDC1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 ROSMAP Brain Pre-frontal Cortex 0.0899 0.0356 0.00053 0.004 0.022 0.012 0.022 0.005 0.094 0.00067 0.0091 0.00073 0.061
2 TCGA Breast Invasive Carcinoma 0.0717 0.0346 0.00250 -0.001 0.005 0.012 NA -0.001 0.920 0.02300 0.0014 NA 0.750

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.7 1.1 1.2 -1.1 -1.0
Bipolar Disorder or Schizophrenia 0.9 2.1 2.8 -1.2 -1.7
Depressed Affect (Nagel 2018) 3.0 6.3 10.4 -3.2 -1.5
Depression (Nagel 2018) 4.3 6.4 10.1 -3.2 -1.6
Intelligence (Savage-Jansen 2018) 0.7 2.3 2.9 1.7 1.3
Neuroticism (Nagel 2018) 4.1 9.6 17.1 -4.1 -1.4
Schizophrenia (2018) 0.5 1.0 1.5 -0.6 -1.2
Schizophrenia vs Biploar Disorder 1.3 1.7 2.3 1.5 1.1
Worry (Nagel 2018) 0.4 0.9 1.5 -1.2 0.4
Alzheimer’s Disease (in mother) 0.8 1.0 1.0 -1.0 1.0
Alzheimer’s Disease (in father) 1.5 1.7 1.8 -1.2 -1.3
Alzheimer’s Disease (including proxy) 0.8 1.2 2.4 -1.6 0.1
Crohns Disease (2017) 0.1 0.2 0.4 -0.6 -0.1
Irritable Bowel Disease (IBD) 0.3 0.7 1.4 -0.0 1.2
Ulcerative Colitis (UC) 1.0 1.8 2.6 1.0 1.6
Major Depression (MDD) 0.7 0.9 1.5 -1.2 0.5
Reaction Time 1.0 1.9 3.4 1.8 -0.6
Verbal and Numeric Reasoning (VNR) 0.4 0.9 1.1 1.1 0.9
Breast Cancer 0.5 1.1 1.6 -1.3 -0.8
Ovarian Cancer 0.6 0.8 1.6 -0.0 1.3
Prostate Cancer 0.0 0.0 0.0 0.1 -0.1
Age at First Birth 0.0 0.1 0.1 0.0 0.3
Bipolar Disorder (2011) 1.9 1.8 3.6 0.3 -1.9
Body Mass Index (BMI) (2010) 2.4 3.3 3.3 -1.8 -1.8
Coronary Artery Disease (CAD) 0.6 0.7 1.4 -0.2 -1.2
Crohns Disease (2012) 0.2 0.4 0.7 -0.8 0.2
Mean Putamen Volume 0.3 0.4 0.7 -0.9 0.1
Fasting Glucose 1.8 2.1 4.0 -2.0 0.6
HbA1C 0.1 0.2 0.2 0.3 -0.4
HDL Cholesterol 0.3 0.5 1.0 -0.1 1.0
LDL Cholesterol 1.3 2.1 3.7 1.9 0.7
Lupus 0.3 0.4 0.5 0.7 -0.6
Neuroticism (2016) 0.1 0.2 0.3 -0.5 -0.1
Primary Biliary Cirrhosis 0.3 0.5 0.8 -0.4 0.9
Rheumatoid Arthritis 0.0 0.0 0.0 0.2 -0.0
Schizophrenia (2014) 0.2 0.5 0.9 1.0 -0.3
Triglycerides 0.1 0.2 0.2 -0.4 -0.5
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.1 -0.3 -0.1
Ulcerative Colitis 0.5 0.7 1.4 0.3 1.2
Blood Eosinophil Count 0.0 0.2 0.2 -0.5 -0.4
Blood Platelet Count 0.0 0.4 0.9 0.9 -0.1
Blood Red Count 0.3 2.5 4.0 1.0 -2.0
Blood White Count 0.3 2.2 3.5 -1.9 -1.0
Heel T-Score 0.0 0.4 0.4 0.6 -0.6
BMI 2.6 15.3 15.7 -4.0 -3.9
Height 0.1 2.2 2.9 1.7 -1.2
Waist Hip Ratio (WHR) 0.6 2.8 4.2 -2.0 -1.2
Systolic Blood Pressure 0.3 1.6 3.1 1.8 0.4
Smoking Status 0.1 0.3 0.6 0.0 0.8
Allergy or Eczema 0.4 1.0 1.2 -1.1 0.9
Cardiovascular Disease 0.5 1.7 2.6 -1.0 -1.6
Hypothyroidism (self reported) 0.5 1.1 2.0 -1.4 -0.5
Respiratory disease 0.2 0.5 1.1 -1.0 -0.1
Type 2 Diabetes (T2D) (2018) 0.2 0.4 0.7 0.8 0.3
Lung FEV1/FVC ratio 0.3 1.4 2.6 0.2 1.6
Lung FVC 0.0 0.2 0.4 -0.6 -0.2
Neuroticism 2.3 5.5 8.4 -2.9 -1.6
Chronotype (morning person) 1.1 2.6 5.2 2.3 -0.2
Hair Pigment 0.5 13.0 22.6 1.9 4.8
Tanning 1.1 13.9 26.6 1.0 -5.2
Hand grip strength (left) 0.8 2.2 3.4 1.8 1.0
Number of treatments/medications taken 0.4 0.6 0.9 -1.0 -0.6
Average weekly spirits intake 0.5 0.6 1.3 0.0 1.1
Sensitivity / hurt feelings 2.0 3.5 6.6 -2.6 -0.7
Frequency of depressed mood in last 2 weeks 6.4 9.0 15.2 -3.9 -1.7
Hearing difficulty/problems: Yes 0.1 0.2 0.3 -0.0 0.6
Relative age of first facial hair 0.2 0.4 0.7 -0.8 0.4
Other serious medical condition/disability diagnosed by doctor 0.1 0.1 0.2 -0.5 -0.2
Ever used hormone-replacement therapy (HRT) 0.0 0.0 0.1 0.1 0.3
Ever had hysterectomy (womb removed) 0.3 0.3 0.3 -0.5 -0.6
Systolic blood pressure, automated reading 0.0 0.0 0.0 0.1 -0.2
Eye problems/disorders: Diabetes related eye disease 0.7 0.7 1.2 0.5 1.1
Angina 0.3 0.4 0.7 0.1 0.8
Medication for hormone replacement therapy 0.0 0.0 0.0 0.2 -0.2
Vitamin and mineral supplements 1.1 1.5 2.3 -0.9 -1.5
Supplements: Zinc 0.3 0.3 0.6 0.1 0.8
Medication: Co-codamol 0.0 0.1 0.1 0.1 0.3
Medication: Metformin 0.2 0.3 0.5 0.5 0.7
Diabetes (father) 0.3 0.4 0.7 -0.4 0.8
Diabetes (mother) 0.8 1.0 1.9 -1.4 -0.1
Severe depression (siblings) 5.4 6.0 9.4 -3.1 -1.6
Pack years adult smoking proportion 1.1 1.7 2.5 -1.6 -1.0
Impedance of leg (right) 0.6 2.9 4.4 1.2 2.1
Leg fat-free mass (left) 0.6 3.3 6.0 -0.8 -2.4
Trunk fat percentage 1.7 6.9 7.8 -2.5 -2.8
Hand grip strength (right) 1.3 3.6 5.3 2.3 1.4
Townsend deprivation index at recruitment 0.1 0.1 0.1 -0.3 -0.3
Current tobacco smoking 0.2 0.2 0.5 0.1 0.7
Average weekly fortified wine intake 0.2 0.3 0.5 0.7 -0.1
Maternal smoking around birth 0.8 1.1 1.8 -0.6 -1.4
Fed-up feelings 2.1 3.8 5.6 -2.4 -1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 2.8 3.7 6.2 -2.5 -1.1
Relative age voice broke 0.0 0.0 0.0 0.1 0.2
Taking other prescription medications 0.6 0.9 1.6 -1.3 -0.3
Age when periods started (menarche) 0.2 0.5 1.0 0.2 1.0
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 0.9 -1.0 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.1 0.2 -0.5 0.1
Tinnitus: Yes, but not now, but have in the past 0.7 0.7 1.3 -0.4 -1.2
Qualifications: CSEs or equivalent 1.4 1.9 3.1 -1.8 -0.9
Serious illness, injury or assault to yourself 1.3 1.6 1.8 -1.4 -1.2
High blood pressure 1.0 2.9 3.8 -1.4 -2.0
Hayfever, allergic rhinitis or eczema 0.5 1.0 2.0 -1.4 0.1
Multivitamins +/- minerals 2.5 3.1 6.0 0.6 2.4
Stomach or abdominal pain in last month 0.3 0.3 0.5 0.4 -0.7
Supplements: Glucosamine 0.2 0.3 0.5 0.7 0.4
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 0.7 -0.8 0.0
Medication: Atenolol 0.4 0.5 0.7 0.6 -0.8
Medication: Levothyroxine sodium 1.3 2.2 2.2 -1.5 -1.5
Sitting height 0.2 1.5 3.1 1.8 -0.0
Chronic bronchitis/emphysema (father) 0.6 0.7 0.9 -1.0 0.8
High blood pressure (mother) 1.1 1.6 3.1 -0.4 -1.8
Body mass index (BMI) 1.5 6.4 7.2 -2.4 -2.7
Impedance of leg (left) 0.6 3.0 5.3 0.8 2.3
Leg predicted mass (left) 0.6 3.2 5.9 -0.7 -2.4
Trunk fat mass 1.6 6.9 8.9 -2.2 -3.0
Waist circumference 1.7 6.3 7.7 -2.2 -2.8
Number of incorrect matches in round 0.2 0.4 0.6 0.4 0.8
Past tobacco smoking 0.1 0.2 0.4 0.2 -0.6
Alcohol usually taken with meals 0.5 0.8 1.5 1.2 -0.2
Nervous feelings 0.1 0.2 0.3 0.3 0.5
Frequency of tenseness / restlessness in last 2 weeks 2.1 3.3 6.3 -2.5 -0.6
Hearing difficulty/problems with background noise 0.2 0.3 0.3 -0.6 0.5
Hair/balding pattern: Pattern 2 2.2 2.8 4.0 2.0 1.2
Had menopause 0.1 0.1 0.2 -0.1 0.5
Had other major operations 1.1 1.4 2.7 -1.6 -0.3
Forced vital capacity (FVC) 0.1 0.3 0.3 0.6 0.5
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 0.5 -0.6 -0.7
Ever unenthusiastic/disinterested for a whole week 4.8 5.9 6.3 -2.3 -2.5
Qualifications: None of the above 0.1 0.2 0.2 -0.4 0.5
Financial difficulties in last 2 years 1.0 1.3 2.0 0.8 -1.4
Mouth/teeth dental problems 0.1 0.2 0.3 0.1 -0.5
Heart attack 1.1 1.4 2.3 -0.7 -1.5
Allergy 0.7 1.7 2.6 1.6 -0.8
Pain all over the body in last month 1.5 1.6 2.7 0.6 -1.7
Diabetes (self-reported) 0.1 0.1 0.2 -0.4 0.2
Hayfever/allergic rhinitis (self-reported) 0.4 0.6 1.0 0.4 -1.0
Medication: Ramipril 1.2 1.5 3.0 -0.2 -1.7
Medication: Simvastatin 1.2 1.7 3.3 -1.8 -0.4
Fluid intelligence score 0.5 1.0 1.0 1.0 1.0
Illnesses of siblings 0.9 1.3 1.8 0.9 1.4
Neuroticism score 2.2 4.6 7.9 -2.8 -1.2
Weight 0.8 4.0 6.6 -1.2 -2.6
Impedance of arm (right) 0.3 1.4 1.6 1.1 1.3
Arm fat percentage (right) 1.5 6.0 6.6 -2.6 -2.3
Trunk fat-free mass 0.0 0.2 0.4 0.2 -0.6
Hip circumference 0.7 3.1 5.1 -1.0 -2.3
Time employed in main current job 0.7 0.8 1.4 1.2 -0.3
Alcohol intake versus 10 years previously 0.2 0.3 0.6 -0.2 -0.8
Father’s age at death 0.7 1.0 1.3 -0.8 -1.2
Worrier / anxious feelings 1.6 3.1 6.2 -2.5 -0.0
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 0.4 -0.6 -0.4
Falls in the last year 3.2 4.4 6.1 -1.6 -2.5
Hair/balding pattern: Pattern 3 0.8 1.1 1.6 -0.8 -1.3
Number of live births 1.4 2.0 4.0 -2.0 -0.1
Forced expiratory volume in 1-second (FEV1) 0.1 0.3 0.4 0.6 0.6
Pulse rate 0.4 0.7 1.1 1.1 0.6
Happiness 0.1 0.2 0.3 0.3 -0.5
Noisy workplace 1.0 1.3 1.7 -1.3 -0.9
Qualifications: A levels/AS levels or equivalent 1.6 3.5 5.7 2.4 -1.1
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 1.2 -0.2 -1.1
Mouth/teeth dental problems: Dentures 0.3 0.5 0.6 -0.8 -0.6
Asthma 0.3 0.6 1.3 0.0 1.1
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 0.9 1.0 1.0
Medication: Cholesterol lowering 0.1 0.1 0.2 -0.1 0.4
Depression (self-reported) 0.4 0.5 0.8 -0.9 -0.4
Medication: Lansoprazole 3.5 4.0 7.2 -2.7 -0.9
Prospective memory result 1.4 1.8 2.5 1.0 1.6
Lung cancer (father) 0.0 0.0 0.0 -0.2 0.0
Illnesses of mother 2.7 3.3 5.6 1.1 2.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.0 0.1 0.3 0.5 0.1
Pulse wave Arterial Stiffness index 0.2 0.3 0.6 -0.8 -0.0
Impedance of arm (left) 0.2 0.8 0.9 1.0 0.9
Arm fat mass (right) 1.2 5.1 5.6 -2.2 -2.4
Trunk predicted mass 0.0 0.2 0.3 0.3 -0.5
Standing height 0.2 2.3 4.5 2.1 0.1
Length of working week for main job 0.4 0.5 0.9 -1.0 -0.1
Exposure to tobacco smoke at home 0.8 0.9 1.6 0.5 1.2
Breastfed as a baby 0.2 0.3 0.5 -0.7 -0.2
Tense / ‘highly strung’ 1.9 3.1 6.1 -2.5 0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 12.7 19.4 33.1 -5.8 -2.4
Hair/balding pattern: Pattern 4 1.2 2.9 5.8 -2.4 0.1
Birth weight of first child 0.5 1.0 1.6 -1.3 0.5
Peak expiratory flow (PEF) 0.0 0.1 0.2 -0.4 -0.0
Pulse wave reflection index 1.2 1.5 2.9 -1.7 -0.4
Ever highly irritable/argumentative for 2 days 1.5 1.8 3.6 -1.9 0.1
Loud music exposure frequency 0.8 0.9 1.4 -1.2 -0.6
Qualifications: O levels/GCSEs or equivalent 0.9 1.5 1.8 -1.4 -1.0
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.1 0.3 0.3
Blood clot in the leg (DVT) 0.0 0.0 0.0 0.1 -0.0
Medication: Paracetamol 0.3 0.5 1.1 0.1 1.0
Headache pain in last month 2.0 3.4 5.2 2.3 1.2
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 1.7 1.3 0.6
Glaucoma (self-reported) 0.1 0.1 0.1 0.2 0.4
Gout (self-reported) 0.2 0.3 0.5 -0.4 -0.7
Hypothyroidism/myxoedema (self-reported) 0.9 1.8 3.0 -1.7 -0.7
Medication: Amlodipine 0.4 0.6 1.1 0.3 -1.1
Medication: Ventolin 100micrograms inhaler 0.3 0.3 0.6 0.8 -0.1
Birth weight 2.6 5.6 7.1 -2.7 -2.0
Chronic bronchitis/emphysema (mother) 0.4 0.4 0.5 -0.7 -0.6
High blood pressure (siblings) 1.8 2.7 3.4 -1.4 -1.9
Forced vital capacity (FVC), Best measure 0.1 0.3 0.5 0.7 0.3
Body fat percentage 1.7 6.8 7.0 -2.6 -2.6
Leg fat percentage (right) 1.5 5.6 6.5 -2.5 -2.2
Arm fat-free mass (right) 0.3 1.4 2.6 -0.5 -1.6
Exposure to tobacco smoke outside home 2.2 3.0 3.1 -1.8 -1.7
Comparative body size at age 10 1.0 2.9 3.2 -1.6 -1.8
Number of full brothers 0.8 1.0 1.7 -1.3 -0.5
Worry too long after embarrassment 3.6 6.1 10.5 -3.2 -1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 4.3 5.6 8.0 -2.8 -1.8
Wheeze or whistling in the chest in last year 0.7 1.2 1.2 -1.1 -1.1
Number of children fathered 0.8 0.9 1.8 0.2 -1.4
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 0.9 -0.4 -0.9
Age at first live birth 0.6 1.1 2.2 1.5 0.1
Pulse wave peak to peak time 0.3 0.4 0.8 0.9 -0.1
Health satisfaction 0.1 0.1 0.2 -0.4 -0.3
Shortness of breath walking on level ground 0.4 0.5 0.9 0.3 -0.9
Qualifications: College or University degree 0.4 1.4 2.4 1.5 0.6
Eye problems/disorders: None of the above 0.3 0.3 0.5 -0.7 0.4
Mouth/teeth dental problems: Loose teeth 1.3 1.6 1.9 -1.1 -1.4
Emphysema/chronic bronchitis 0.8 0.9 1.8 -1.3 0.2
Medication for pain relief, constipation, heartburn 0.0 0.0 0.0 0.1 -0.2
Neck or shoulder pain in last month 1.7 2.4 3.5 -1.9 1.1
Medication: Blood pressure 1.2 2.1 2.4 -1.3 -1.5
Angina (self-reported) 0.2 0.3 0.5 -0.2 0.7
Migraine (self-reported) 0.1 0.2 0.2 -0.5 0.4
Medication: Ibuprofen 0.6 0.7 1.2 1.1 0.3
Medication: Allopurinol 1.5 2.0 3.7 -0.5 -1.9
Medication: Omeprazole 0.6 0.7 1.4 -0.2 -1.2
Medication: Seretide 50 evohaler 0.6 0.7 1.2 0.5 1.1
Mean time to correctly identify matches 0.3 0.6 0.7 0.7 -0.8
Heart disease (mother) 1.8 2.2 4.0 -0.6 -2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 0.9 1.0 1.0 0.9
Whole body fat mass 1.3 5.5 6.9 -2.0 -2.6
Leg fat mass (right) 1.4 5.4 6.5 -2.1 -2.5
Arm predicted mass (right) 0.3 1.8 2.7 -0.9 -1.6
Pulse rate, automated reading 0.2 0.6 1.1 1.0 0.5
Alcohol intake frequency. 0.7 1.5 2.3 -0.9 -1.5
Comparative height size at age 10 0.2 1.3 2.2 1.5 0.7
Number of full sisters 1.3 1.6 2.6 -1.6 -0.7
Suffer from ‘nerves’ 0.4 0.7 1.1 -0.5 1.1
Overall health rating 1.1 2.3 2.8 -1.7 -1.3
Chest pain or discomfort 0.3 0.5 0.9 0.2 0.9
Had major operations 0.1 0.2 0.2 -0.5 -0.4
Age at last live birth 0.1 0.2 0.3 -0.6 -0.1
Family relationship satisfaction 0.4 0.5 0.9 0.5 0.9
Leg pain on walking 4.2 5.3 6.0 -2.5 -2.1
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 0.7 -0.5 -0.9
Commuting to job workplace: Car/motor vehicle 0.4 0.5 0.9 -0.2 -1.0
Illness, injury, bereavement, stress in last 2 years 3.0 3.6 6.7 0.8 2.6
Medication: Aspirin 2.9 3.8 5.4 -2.3 -1.4
Supplements: Vitamin C 0.2 0.2 0.2 0.5 0.5
Knee pain experienced in last month 0.3 0.5 0.6 -0.8 0.6
Hypertension (Self-reported) 1.4 4.0 5.9 -1.4 -2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.0 1.2 2.0 -1.4 -0.6
Illnesses of father: Heart disease 0.7 0.9 1.5 -0.6 -1.2
Illnesses of siblings: Diabetes 0.2 0.2 0.3 -0.6 0.3
Smoking status: Previous 0.2 0.3 0.7 0.0 0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 0.9 0.9 0.6
Whole body fat-free mass 0.2 1.0 1.9 -0.3 -1.4
Leg fat-free mass (right) 0.5 2.8 5.0 -0.8 -2.2
Arm fat percentage (left) 1.7 6.9 7.1 -2.7 -2.6
Average weekly red wine intake 0.8 1.1 1.1 -1.1 -1.1
Handedness (chirality/laterality): Left-handed 0.0 0.0 0.0 -0.1 -0.1
Mood swings 0.9 1.7 1.9 -1.4 -1.2
Loneliness, isolation 4.0 5.5 10.6 -3.2 0.7
Long-standing illness, disability or infirmity 0.2 0.3 0.5 -0.4 0.7
Ever had bowel cancer screening 0.6 0.7 0.8 -0.8 0.9
Diabetes diagnosed by doctor 0.0 0.1 0.1 -0.3 0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.8 1.5 -0.1 -1.2
Friendships satisfaction 0.3 0.4 0.5 -0.4 -0.7
Qualifications: nursing, teaching 0.1 0.2 0.4 -0.0 -0.6
Commuting to job workplace: Walk 0.1 0.1 0.1 -0.1 0.3
Eye problems/disorders: Cataract 0.2 0.2 0.3 0.6 0.0
Mouth/teeth dental problems: Mouth ulcers 0.8 1.3 1.9 1.4 0.8
Medication for cholesterol 1.2 1.9 3.0 0.9 1.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.0 0.0 0.0 -0.0 0.0
Back pain experienced in last month 0.3 0.4 0.7 -0.8 -0.4
Mineral and other dietary supplements 0.0 0.0 0.1 -0.3 -0.1
Breast cancer (self-reported) 1.5 1.8 2.7 0.9 1.6
Asthma (self-reported) 0.3 0.6 1.1 -0.1 1.1
Osteoporosis (self-reported) 1.5 1.9 3.7 -0.1 -1.9
Osteoarthritis (self-reported) 0.0 0.0 0.0 0.1 -0.2
Medication: Aspirin 2.9 3.7 5.1 -2.2 -1.6
Medication: Gliclazide 0.3 0.3 0.6 0.8 -0.2
Illnesses of father: None of the above (group 1) 0.9 1.1 1.9 0.6 1.4
Smoking status: Current 0.0 0.1 0.1 0.3 0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 1.3 -1.1 -0.7
Whole body water mass 0.2 0.9 1.8 -0.2 -1.3
Leg predicted mass (right) 0.5 2.8 5.1 -0.8 -2.2
Arm fat mass (left) 1.2 5.1 6.1 -2.0 -2.5
Number of self-reported non-cancer illnesses 2.0 3.5 6.8 -2.6 -0.4
Average weekly champagne plus white wine intake 1.6 2.3 4.5 2.1 0.3
Miserableness 2.1 3.6 6.6 -2.6 -0.9
Guilty feelings 3.6 5.4 9.0 -3.0 -1.3
Wears glasses or contact lenses 0.4 0.5 0.7 -0.5 -0.8
Ever taken oral contraceptive pill 0.4 0.5 0.7 0.8 -0.5
Hearing aid user 0.1 0.1 0.1 -0.1 0.4
Mother’s age at death 0.7 0.9 1.6 1.3 0.5
Financial situation satisfaction 2.1 2.5 4.7 0.6 -2.2
Tinnitus: Yes, now most or all of the time 0.6 0.7 1.2 0.3 1.1
Commuting to job workplace: Public transport 0.4 0.5 1.0 -1.0 -0.3
Eye problems/disorders: Glaucoma 0.3 0.3 0.6 0.8 0.0
Medication: Blood pressure 0.8 1.6 2.5 -0.8 -1.6
Pain type(s) experienced in last month: Hip pain 0.7 0.8 1.4 -0.5 1.2
Supplements: Fish oil (including cod liver oil) 1.6 2.1 3.9 0.7 2.0
High cholesterol (Self-reported) 1.0 1.9 3.1 -1.8 -0.8
Medication: Bendroflumethiazide 0.1 0.2 0.3 -0.3 -0.5
Medication: Paracetamol 0.2 0.3 0.6 -0.1 0.7
Medication: Lisinopril 0.8 1.0 1.6 0.7 1.2
Medication: Atorvastatin 0.2 0.2 0.3 0.4 -0.5
Illnesses of father: High blood pressure 0.1 0.2 0.3 0.6 0.2
Alcohol drinker status: Never 0.0 0.0 0.1 -0.0 0.3
Ever smoked 0.3 0.5 0.9 -0.9 0.2
Basal metabolic rate 0.3 1.6 2.9 -0.5 -1.7
Leg fat percentage (left) 1.7 6.1 7.9 -2.8 -2.1
Arm fat-free mass (left) 0.2 1.0 2.0 -0.3 -1.4
Number of operations (self-reported) 0.5 0.8 1.1 -1.0 0.7
Average weekly beer plus cider intake 0.6 0.8 1.7 0.0 1.3
Irritability 2.8 4.7 7.8 -2.8 -1.2
Risk taking 0.4 0.6 1.1 -1.0 -0.3
Ever had prostate specific antigen (PSA) test 2.0 2.3 2.9 -1.7 -1.3
Fractured/broken bones in last 5 years 0.7 0.9 1.7 -0.4 -1.3
Age started oral contraceptive pill 1.0 1.3 1.5 -1.0 -1.2
Diastolic blood pressure, automated reading 0.6 1.7 2.9 -1.7 -0.8
Ever depressed for a whole week 1.2 1.5 1.9 -1.4 -1.0
Unable to work because of sickness or disability 0.0 0.0 0.0 -0.0 0.1
Commuting to job workplace: Cycle 1.2 1.4 2.9 -1.7 -0.0
Myopia 1.2 1.8 3.5 -1.9 0.1
Vascular/heart problems diagnosed by doctor 0.6 1.7 2.7 0.9 1.6
Cholesterol lowering medication 1.9 2.7 4.5 -2.1 -1.0
Medication: Omeprazole (e.g. Zanprol) 1.6 2.0 2.0 -1.4 -1.4
Pain experienced in last month 0.7 1.1 1.6 -0.8 -1.2
Supplements: Calcium 0.7 0.7 0.8 0.9 0.8
Basal cell carcinoma (self-reported) 0.3 0.3 0.5 -0.7 0.4
Heart attack/myocardial infarction (self-reported) 1.1 1.4 2.3 -0.6 -1.5
Deep venous thrombosis (DVT) (self-reported) 0.0 0.0 0.0 -0.1 -0.1
Heart disease (siblings) 1.1 1.3 2.1 0.7 -1.5
Alcohol drinker status: Previous 0.4 0.5 0.9 -0.2 -0.9
Pack years of smoking 1.2 1.8 2.7 -1.6 -1.0
Impedance of whole body 0.3 1.5 2.1 1.0 1.4
Leg fat mass (left) 1.5 5.9 6.8 -2.3 -2.6
Arm predicted mass (left) 0.2 0.8 1.6 -0.2 -1.2