TWAS hub - NOX4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2560	0.0530	0.00000	0.159	0.232	0.203	0.227	0.205	6.9e-19	7.0e-28	3.6e-24	3.6e-27	1.7e-24
2	TCGA	Breast Invasive Carcinoma	0.0242	0.0116	0.00057	-0.001	0.012	0.004	NA	0.000	5.3e-01	1.6e-03	4.2e-02	NA	2.8e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Tanning	8.3	101.6	169.0	-5.8	13.0
Supplements: Vitamin C	8.1	9.6	12.9	-3.6	2.5
Forced vital capacity (FVC), Best measure	7.1	25.9	28.9	-4.8	5.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	6.0	12.7	15.3	-3.2	3.9
Forced vital capacity (FVC)	5.6	21.5	23.3	-4.4	4.8
Forced expiratory volume in 1-second (FEV1)	5.5	18.6	20.2	-4.1	4.5
Forced expiratory volume in 1-second (FEV1), Best measure	4.9	15.7	17.7	-3.7	4.2
Had major operations	4.9	5.7	6.5	-2.2	2.5
Peak expiratory flow (PEF)	4.8	11.0	14.7	-2.7	3.8
Ever had stillbirth, spontaneous miscarriage or termination	4.6	4.9	6.5	-2.5	1.9
Myopia	4.6	6.7	7.0	-2.6	2.5
Commuting to job workplace: Car/motor vehicle	4.5	5.2	8.3	-1.5	2.9
Lung FVC	4.3	21.8	28.3	-5.3	3.9
Deep venous thrombosis (DVT) (self-reported)	4.3	5.5	6.2	-2.2	2.5
Had menopause	3.9	4.9	6.4	1.8	-2.5
Heart attack/myocardial infarction (self-reported)	3.8	4.9	5.5	-2.3	2.1
Average weekly spirits intake	3.7	4.6	4.7	-2.2	2.1
Heart attack	3.7	4.7	5.4	-2.3	2.0
Comparative height size at age 10	3.7	20.3	24.4	-4.0	4.9
Medication: Omeprazole (e.g. Zanprol)	3.7	4.5	7.2	-1.3	2.7
Reaction Time	3.4	6.5	9.1	3.0	-2.0
Number of self-reported non-cancer illnesses	3.4	5.9	6.9	-2.2	2.6
Mean time to correctly identify matches	3.3	6.3	8.7	2.9	-2.0
Supplements: Fish oil (including cod liver oil)	3.1	4.1	7.7	-2.8	0.7
Comparative body size at age 10	2.8	7.6	12.1	-1.8	3.5
Medication: Omeprazole	2.8	3.3	5.7	-1.0	2.4
Trunk fat-free mass	2.7	15.7	27.4	-2.0	5.2
Qualifications: A levels/AS levels or equivalent	2.6	5.8	8.8	1.6	-3.0
Trunk predicted mass	2.6	15.0	26.1	-2.0	5.1
Breastfed as a baby	2.6	3.2	4.7	-2.2	1.3
Family relationship satisfaction	2.6	3.1	4.1	-2.0	1.5
Intelligence (Savage-Jansen 2018)	2.5	7.7	11.3	2.0	-3.4
Pulse wave reflection index	2.5	3.1	4.3	-2.1	1.4
Glaucoma (self-reported)	2.5	3.0	4.5	-1.2	2.1
Leg predicted mass (right)	2.5	13.3	22.8	-1.9	4.8
Hip circumference	2.4	10.4	19.5	-1.1	4.4
Blood clot in the leg (DVT)	2.4	3.1	3.3	-1.7	1.8
Knee pain experienced in last month	2.4	3.8	4.5	-2.1	1.7
Whole body fat-free mass	2.4	13.8	24.2	-1.8	4.9
Leg fat-free mass (right)	2.4	12.9	22.3	-1.9	4.7
Handedness (chirality/laterality): Left-handed	2.4	2.8	3.9	2.0	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.4	2.9	5.7	0.2	2.4
Whole body water mass	2.4	13.7	23.8	-1.9	4.9
Basal metabolic rate	2.4	13.6	24.7	-1.6	5.0
Worry too long after embarrassment	2.3	3.9	4.8	1.7	-2.2
Ever had prostate specific antigen (PSA) test	2.3	2.6	2.8	-1.6	1.7
Verbal and Numeric Reasoning (VNR)	2.2	5.3	6.8	2.0	-2.6
Number of operations (self-reported)	2.2	3.3	4.8	-2.2	1.3
Number of treatments/medications taken	2.1	3.7	4.8	-1.6	2.2
Leg fat-free mass (left)	2.1	10.9	19.6	-1.5	4.4
Taking other prescription medications	2.1	3.2	4.3	-1.4	2.1
Weight	2.1	10.2	20.2	-0.5	4.5
Frequency of unenthusiasm / disinterest in last 2 weeks	2.0	2.7	2.9	1.6	-1.7
Leg predicted mass (left)	2.0	10.6	19.2	-1.4	4.4
Waist circumference	2.0	7.2	14.1	-0.5	3.8
Bilateral oophorectomy (both ovaries removed)	1.9	2.2	4.1	-2.0	0.4
High cholesterol (Self-reported)	1.9	3.4	4.0	-1.7	2.0
Average weekly fortified wine intake	1.8	2.1	3.6	1.9	-0.8
Arm predicted mass (right)	1.8	9.3	16.8	-1.4	4.1
Mineral and other dietary supplements	1.8	2.4	4.8	2.2	-0.2
Average weekly champagne plus white wine intake	1.8	2.5	4.0	2.0	-1.0
Pain experienced in last month	1.8	3.0	3.8	1.9	-1.5
Arm predicted mass (left)	1.8	9.3	17.1	-1.2	4.1
Age at First Birth	1.7	2.5	3.4	1.3	-1.9
Medication: Amlodipine	1.7	2.4	4.2	0.8	2.0
Height	1.6	30.1	46.8	-3.7	6.8
Supplements: Zinc	1.6	1.7	1.9	1.4	-1.3
Nervous feelings	1.6	3.0	5.0	2.2	-1.0
Allergy	1.6	3.6	3.9	2.0	-1.8
Mouth/teeth dental problems: Bleeding gums	1.6	2.1	3.0	1.7	-1.1
Medication for pain relief, constipation, heartburn	1.6	2.7	2.7	1.6	-1.6
Neck or shoulder pain in last month	1.6	2.2	2.3	-1.5	1.5
Medication: Blood pressure	1.6	2.9	3.1	-1.6	1.8
Illnesses of father: Heart disease	1.6	2.2	3.5	1.9	-1.0
Hearing aid user	1.6	1.8	2.3	-1.1	1.5
Basal cell carcinoma (self-reported)	1.6	1.9	2.8	0.9	-1.7
LDL Cholesterol	1.5	2.3	3.9	2.0	-0.9
Impedance of leg (right)	1.5	7.5	11.8	1.8	-3.4
Time employed in main current job	1.5	1.7	1.9	-1.2	1.4
Happiness	1.5	1.8	2.5	-1.6	1.0
Standing height	1.5	15.1	21.3	-3.0	4.6
Ever highly irritable/argumentative for 2 days	1.5	1.8	2.6	-1.0	1.6
Arm fat-free mass (right)	1.5	7.9	14.2	-1.2	3.8
Leg pain on walking	1.5	1.9	3.5	-1.9	0.6
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	2.0	1.4	-1.3
Osteoarthritis (self-reported)	1.5	2.0	3.1	-0.9	1.8
Arm fat-free mass (left)	1.5	7.6	14.4	-0.9	3.8
Leg fat mass (left)	1.5	6.0	11.8	0.4	3.4
Breast Cancer	1.4	3.3	6.6	0.4	-2.6
Body Mass Index (BMI) (2010)	1.4	1.9	1.9	-1.4	1.4
Trunk fat mass	1.4	6.0	11.9	0.1	3.5
Medication: Simvastatin	1.4	2.0	3.9	-0.4	2.0
Fluid intelligence score	1.4	2.9	5.1	0.9	-2.3
Alcohol intake versus 10 years previously	1.4	2.1	3.7	-0.7	1.9
Falls in the last year	1.4	1.9	2.7	1.1	-1.6
Whole body fat mass	1.4	5.9	11.7	0.4	3.4
Leg fat mass (right)	1.4	5.2	9.7	0.9	3.1
Pulse rate, automated reading	1.4	4.6	5.2	2.0	-2.3
Osteoporosis (self-reported)	1.4	1.8	2.7	-0.9	1.6
Pain type(s) experienced in last month: Hip pain	1.4	1.7	2.2	-1.5	1.1
Illnesses of father: High blood pressure	1.4	1.8	3.0	-1.7	-0.7
Age started oral contraceptive pill	1.4	1.8	2.1	1.5	-1.2
Qualifications: None of the above	1.3	2.7	5.0	-0.6	2.2
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	2.1	-1.5	1.1
Arm fat mass (right)	1.3	5.5	10.9	0.3	3.3
Loneliness, isolation	1.3	1.7	2.2	1.5	-1.1
Arm fat mass (left)	1.3	5.3	10.6	0.3	3.2
Tinnitus: Yes, now most or all of the time	1.3	1.5	1.9	1.0	-1.4
Neuroticism (2016)	1.2	1.7	2.9	1.7	-0.7
Hayfever, allergic rhinitis or eczema	1.2	2.6	3.5	-1.3	1.9
High blood pressure (mother)	1.2	1.6	1.8	1.2	-1.3
Heart disease (mother)	1.2	1.5	2.8	-0.4	1.7
Back pain experienced in last month	1.2	1.7	3.4	-0.3	1.8
Bipolar Disorder (2018)	1.1	1.7	3.3	-1.8	0.1
Depression (Nagel 2018)	1.1	1.6	1.7	1.3	-1.2
Alzheimer’s Disease (in mother)	1.1	1.2	2.1	-1.5	0.6
BMI	1.1	6.6	12.8	-0.6	3.6
Respiratory disease	1.1	2.4	3.3	-1.8	1.2
Impedance of leg (left)	1.1	5.4	9.4	1.1	-3.1
Medication: Lansoprazole	1.1	1.2	1.3	-1.1	1.1
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	3.5	-0.2	-1.9
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	2.1	1.2	-1.5
Exposure to tobacco smoke outside home	1.1	1.4	1.8	1.3	-1.0
Age at first live birth	1.1	2.0	2.5	1.6	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.2	2.9	-1.2	1.7
Impedance of whole body	1.1	5.8	10.9	0.8	-3.3
Neuroticism score	1.0	2.0	3.7	1.9	-0.6
Arm fat percentage (right)	1.0	3.8	7.1	0.7	2.7
Illnesses of mother	1.0	1.2	2.3	-0.2	-1.5
Number of children fathered	1.0	1.1	1.9	0.5	1.4
Health satisfaction	1.0	1.3	2.6	-1.6	0.2
Eye problems/disorders: None of the above	1.0	1.1	1.5	0.9	-1.2
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	1.6	0.9	-1.3
Ever depressed for a whole week	1.0	1.3	2.6	-1.6	0.0
Coronary Artery Disease (CAD)	0.9	1.1	1.4	-0.9	1.2
Neuroticism	0.9	2.1	3.3	1.8	-0.9
Diabetes (father)	0.9	1.1	1.3	-1.0	-1.1
Body mass index (BMI)	0.9	3.6	6.8	0.7	2.6
Father’s age at death	0.9	1.2	2.4	-1.6	0.0
Medication: Paracetamol	0.9	1.5	2.0	-1.4	1.0
Leg fat percentage (right)	0.9	3.2	4.0	2.0	1.6
Number of full brothers	0.9	1.2	1.2	1.1	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	2.0	-0.0	1.4
Commuting to job workplace: Public transport	0.9	1.0	1.5	0.7	-1.2
Medication: Paracetamol	0.9	1.4	1.4	-1.2	1.2
Triglycerides	0.8	1.3	1.5	1.2	1.1
Medication: Co-codamol	0.8	0.9	1.3	-1.1	0.7
Medication: Atenolol	0.8	1.0	1.8	0.5	-1.4
Sitting height	0.8	5.3	9.0	-1.3	3.0
Mouth/teeth dental problems	0.8	1.3	2.5	-1.6	-0.2
Number of live births	0.8	1.2	2.3	-1.5	0.1
Mouth/teeth dental problems: Dentures	0.8	1.3	2.3	0.6	1.5
Birth weight of first child	0.8	1.5	3.0	-0.2	1.7
Medication: Ibuprofen	0.8	0.9	1.1	-1.1	0.8
Chest pain or discomfort	0.8	1.1	1.3	1.1	1.0
Smoking status: Previous	0.8	1.2	1.8	-0.8	1.4
Arm fat percentage (left)	0.8	3.3	6.2	0.6	2.5
Eye problems/disorders: Cataract	0.8	0.9	1.7	-1.3	-0.2
Eye problems/disorders: Glaucoma	0.8	1.0	1.9	0.1	1.4
Leg fat percentage (left)	0.8	2.8	3.8	1.4	1.9
Alzheimer’s Disease (including proxy)	0.7	1.1	1.5	-1.2	0.8
Crohns Disease (2017)	0.7	1.5	2.7	1.6	-0.6
Major Depression (MDD)	0.7	0.9	1.7	1.3	-0.3
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	0.9	1.0	-0.8
Diabetes (mother)	0.7	0.8	1.5	-1.2	0.4
Fed-up feelings	0.7	1.2	1.9	1.4	-0.8
Hair/balding pattern: Pattern 2	0.7	0.9	1.5	-1.2	-0.5
Had other major operations	0.7	0.8	1.1	-1.0	0.7
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	1.1	-1.0	0.7
Illnesses of siblings	0.7	1.0	1.8	-1.3	0.4
Suffer from ‘nerves’	0.7	1.2	1.3	1.0	-1.1
Overall health rating	0.7	1.5	1.8	-1.1	1.3
Qualifications: nursing, teaching	0.7	1.1	1.7	0.7	-1.3
Ovarian Cancer	0.6	0.8	1.1	-1.0	0.7
Crohns Disease (2012)	0.6	1.0	1.9	1.4	-0.4
Sensitivity / hurt feelings	0.6	1.0	1.0	0.9	-1.0
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.4	1.2	-0.5
Vitamin and mineral supplements	0.6	0.9	1.7	1.3	0.1
Severe depression (siblings)	0.6	0.7	1.4	1.2	-0.2
Age when periods started (menarche)	0.6	1.4	1.5	1.2	-1.2
Supplements: Glucosamine	0.6	0.8	1.6	-1.3	-0.2
Pain all over the body in last month	0.6	0.7	1.0	0.6	1.0
Birth weight	0.6	1.4	2.1	-0.8	1.4
Body fat percentage	0.6	2.4	3.3	1.2	1.8
Qualifications: College or University degree	0.6	1.9	3.7	-0.1	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	0.8	-0.9	0.9
Smoking status: Current	0.6	0.9	1.4	-1.2	0.6
Ever smoked	0.6	1.1	1.1	-1.0	1.1
Risk taking	0.6	0.9	1.3	-1.2	0.6
Bipolar Disorder or Schizophrenia	0.5	1.3	2.3	-1.5	0.5
Worry (Nagel 2018)	0.5	1.0	2.0	1.4	0.3
Bipolar Disorder (2011)	0.5	0.5	0.7	-0.6	0.8
Systolic Blood Pressure	0.5	2.4	3.5	1.9	-1.1
Allergy or Eczema	0.5	1.4	1.5	-1.2	1.2
Cardiovascular Disease	0.5	1.5	2.7	-0.6	1.6
Ever used hormone-replacement therapy (HRT)	0.5	0.6	0.9	1.0	-0.5
Systolic blood pressure, automated reading	0.5	1.3	1.8	1.4	-0.9
Pack years adult smoking proportion	0.5	0.8	0.8	0.9	-0.9
Trunk fat percentage	0.5	2.0	3.3	0.8	1.8
Townsend deprivation index at recruitment	0.5	0.7	1.0	0.6	-1.0
Current tobacco smoking	0.5	0.9	1.3	-1.1	0.7
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.2	-0.1	1.1
Past tobacco smoking	0.5	1.0	1.1	0.9	-1.1
Impedance of arm (left)	0.5	2.2	4.3	-0.2	-2.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.2	1.1	0.7
High blood pressure (siblings)	0.5	0.7	1.3	1.1	-0.0
Emphysema/chronic bronchitis	0.5	0.5	0.6	-0.7	0.8
Medication: Lisinopril	0.5	0.7	1.4	-0.2	1.2
Neuroticism (Nagel 2018)	0.4	1.0	2.1	1.4	0.2
Mean Putamen Volume	0.4	0.5	0.7	0.8	-0.5
Primary Biliary Cirrhosis	0.4	0.5	1.0	1.0	-0.2
Heel T-Score	0.4	3.5	6.1	1.0	-2.5
Smoking Status	0.4	1.0	1.5	-0.7	1.2
Hearing difficulty/problems: Yes	0.4	0.6	0.9	-1.0	-0.5
Depression (self-reported)	0.4	0.5	1.0	1.0	0.0
Pulse wave Arterial Stiffness index	0.4	0.4	0.4	-0.6	0.7
Alcohol intake frequency.	0.4	0.9	1.4	0.7	1.2
Age at last live birth	0.4	0.5	0.7	0.6	-0.9
Long-standing illness, disability or infirmity	0.4	0.7	1.0	1.0	-0.6
Commuting to job workplace: Walk	0.4	0.4	0.5	-0.7	-0.6
Medication for cholesterol	0.4	0.6	1.1	-0.4	-1.1
Mother’s age at death	0.4	0.5	0.9	-0.9	0.3
Financial situation satisfaction	0.4	0.5	0.7	-0.8	0.6
Medication: Blood pressure	0.4	0.8	1.5	1.2	-0.0
Medication: Atorvastatin	0.4	0.5	0.8	0.3	-0.9
Unable to work because of sickness or disability	0.4	0.5	0.6	0.6	0.8
Heart disease (siblings)	0.4	0.5	0.8	-0.5	0.9
Alcohol drinker status: Previous	0.4	0.5	0.9	0.3	0.9
Pack years of smoking	0.4	0.5	0.6	0.8	-0.7
Fasting Glucose	0.3	0.3	0.5	-0.4	-0.7
HDL Cholesterol	0.3	0.4	0.6	-0.8	0.5
Hand grip strength (left)	0.3	0.9	1.7	-1.3	0.3
Relative age of first facial hair	0.3	0.6	0.7	0.9	-0.7
Relative age voice broke	0.3	0.4	0.8	0.2	0.9
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.4	0.6	0.6
Serious illness, injury or assault to yourself	0.3	0.4	0.4	-0.6	0.6
Stomach or abdominal pain in last month	0.3	0.3	0.7	0.0	0.8
Chronic bronchitis/emphysema (father)	0.3	0.3	0.6	-0.3	0.8
Alcohol usually taken with meals	0.3	0.5	0.9	1.0	0.4
Financial difficulties in last 2 years	0.3	0.4	0.4	0.6	-0.7
Hayfever/allergic rhinitis (self-reported)	0.3	0.3	0.4	-0.6	0.5
Medication: Ramipril	0.3	0.3	0.5	-0.4	0.7
Impedance of arm (right)	0.3	1.4	2.9	-0.1	-1.7
Pulse rate	0.3	0.5	0.8	0.5	-0.9
Medication: Cholesterol lowering	0.3	0.5	0.9	-0.3	1.0
Exposure to tobacco smoke at home	0.3	0.3	0.4	-0.5	-0.6
Hair/balding pattern: Pattern 4	0.3	0.8	1.0	0.8	1.0
Loud music exposure frequency	0.3	0.4	0.7	0.8	0.2
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.7	-0.3	0.8
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.7	0.0	0.8
Migraine (self-reported)	0.3	0.3	0.4	-0.6	0.5
Medication: Allopurinol	0.3	0.4	0.7	-0.3	0.9
Medication: Seretide 50 evohaler	0.3	0.4	0.8	-0.9	-0.0
Illnesses of siblings: Diabetes	0.3	0.3	0.4	-0.7	-0.4
Average weekly red wine intake	0.3	0.4	0.7	-0.9	-0.2
Average weekly beer plus cider intake	0.3	0.4	0.5	-0.6	0.7
Irritability	0.3	0.5	1.1	-0.2	1.0
Commuting to job workplace: Cycle	0.3	0.3	0.4	-0.5	0.7
Cholesterol lowering medication	0.3	0.5	0.6	0.6	0.8
Depressed Affect (Nagel 2018)	0.2	0.5	0.9	1.0	-0.1
Alzheimer’s Disease (in father)	0.2	0.3	0.5	0.1	0.7
Irritable Bowel Disease (IBD)	0.2	0.5	1.0	1.0	-0.2
HbA1C	0.2	0.2	0.4	0.7	-0.2
Hypothyroidism (self reported)	0.2	0.4	0.7	0.8	-0.2
Chronotype (morning person)	0.2	0.5	0.7	0.8	0.5
Hair Pigment	0.2	4.9	7.8	-2.8	-1.4
Ever had hysterectomy (womb removed)	0.2	0.2	0.2	-0.5	-0.3
Medication for hormone replacement therapy	0.2	0.2	0.5	-0.7	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.7	-0.3	-0.8
Qualifications: CSEs or equivalent	0.2	0.3	0.6	-0.8	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.6	-0.8	0.2
Worrier / anxious feelings	0.2	0.4	0.8	0.9	-0.2
Hair/balding pattern: Pattern 3	0.2	0.2	0.4	0.1	0.7
Asthma	0.2	0.3	0.6	-0.8	-0.2
Prospective memory result	0.2	0.3	0.6	-0.1	0.8
Length of working week for main job	0.2	0.2	0.2	0.5	0.4
Wheeze or whistling in the chest in last year	0.2	0.4	0.7	-0.9	0.2
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.4	0.4	-0.6
Number of full sisters	0.2	0.3	0.6	0.0	-0.8
Friendships satisfaction	0.2	0.3	0.4	-0.5	-0.6
Breast cancer (self-reported)	0.2	0.2	0.4	-0.6	0.1
Asthma (self-reported)	0.2	0.5	0.9	-1.0	0.1
Ever taken oral contraceptive pill	0.2	0.2	0.4	0.6	-0.1
Diastolic blood pressure, automated reading	0.2	0.5	1.1	0.0	-1.0
Vascular/heart problems diagnosed by doctor	0.2	0.4	0.9	0.0	-0.9
Schizophrenia (2018)	0.1	0.3	0.3	-0.5	0.6
Schizophrenia vs Biploar Disorder	0.1	0.1	0.2	0.4	-0.3
Prostate Cancer	0.1	0.1	0.1	0.3	0.2
Lupus	0.1	0.1	0.1	-0.1	-0.4
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.3	0.1	-0.5
Blood Platelet Count	0.1	0.7	1.0	0.7	-1.0
Blood White Count	0.1	0.7	1.1	1.1	0.5
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.1	0.3	-0.4
Angina	0.1	0.2	0.4	-0.0	0.6
Medication: Metformin	0.1	0.2	0.4	0.2	-0.6
Hand grip strength (right)	0.1	0.2	0.3	-0.6	-0.0
Maternal smoking around birth	0.1	0.1	0.1	0.1	0.4
High blood pressure	0.1	0.2	0.4	0.1	0.6
Medication: Levothyroxine sodium	0.1	0.1	0.2	0.3	0.4
Number of incorrect matches in round	0.1	0.1	0.1	0.3	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.4	-0.7	-0.2
Diabetes (self-reported)	0.1	0.1	0.2	-0.4	0.0
Noisy workplace	0.1	0.1	0.1	-0.1	-0.3
Lung cancer (father)	0.1	0.1	0.2	0.5	-0.1
Headache pain in last month	0.1	0.2	0.4	0.1	-0.6
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.2	0.5	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.3	-0.2	0.6
Angina (self-reported)	0.1	0.1	0.2	-0.1	0.5
Medication: Aspirin	0.1	0.1	0.1	-0.2	0.4
Hypertension (Self-reported)	0.1	0.4	0.7	0.0	0.9
Mood swings	0.1	0.2	0.4	0.1	0.6
Ever had bowel cancer screening	0.1	0.2	0.2	-0.3	0.5
Guilty feelings	0.1	0.2	0.3	0.4	-0.5
Fractured/broken bones in last 5 years	0.1	0.1	0.1	-0.2	0.4
Supplements: Calcium	0.1	0.1	0.1	-0.2	-0.3
Ulcerative Colitis (UC)	0.0	0.1	0.1	0.1	0.3
Rheumatoid Arthritis	0.0	0.0	0.0	-0.2	0.1
Schizophrenia (2014)	0.0	0.1	0.1	-0.4	-0.1
Ulcerative Colitis	0.0	0.1	0.1	0.3	-0.2
Blood Eosinophil Count	0.0	0.2	0.4	-0.7	-0.0
Blood Red Count	0.0	0.5	0.6	0.8	0.6
Waist Hip Ratio (WHR)	0.0	0.0	0.0	0.1	-0.2
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.0	-0.2	0.0
Lung FEV1/FVC ratio	0.0	0.1	0.2	0.4	0.1
Multivitamins +/- minerals	0.0	0.0	0.0	-0.0	-0.2
Hearing difficulty/problems with background noise	0.0	0.0	0.1	-0.2	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.0	0.1	-0.1	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.1	-0.1	0.2
Tense / ‘highly strung’	0.0	0.1	0.1	-0.2	0.3
Gout (self-reported)	0.0	0.0	0.0	0.2	-0.0
Pulse wave peak to peak time	0.0	0.0	0.0	0.2	-0.1
Shortness of breath walking on level ground	0.0	0.0	0.0	0.1	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.1	0.2	-0.1
Diabetes diagnosed by doctor	0.0	0.0	0.0	0.2	0.0
Mouth/teeth dental problems: Mouth ulcers	0.0	0.0	0.0	0.1	-0.0
Medication: Aspirin	0.0	0.1	0.1	0.3	0.0
Medication: Gliclazide	0.0	0.0	0.0	0.1	-0.0
Illnesses of father: None of the above (group 1)	0.0	0.0	0.1	0.2	0.1
Miserableness	0.0	0.1	0.1	0.2	0.3
Wears glasses or contact lenses	0.0	0.0	0.0	0.2	0.1
Medication: Bendroflumethiazide	0.0	0.0	0.0	-0.1	0.1
Alcohol drinker status: Never	0.0	0.1	0.1	0.2	0.3

Hub : Genes

NOX4

Models

Trait associations