Hub : Genes

NOX4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.2560 0.0530 0.00000 0.159 0.232 0.203 0.227 0.205 6.9e-19 7.0e-28 3.6e-24 3.6e-27 1.7e-24
2 TCGA Breast Invasive Carcinoma 0.0242 0.0116 0.00057 -0.001 0.012 0.004 NA 0.000 5.3e-01 1.6e-03 4.2e-02 NA 2.8e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.1 1.7 3.3 -1.8 0.1
Bipolar Disorder or Schizophrenia 0.5 1.3 2.3 -1.5 0.5
Depressed Affect (Nagel 2018) 0.2 0.5 0.9 1.0 -0.1
Depression (Nagel 2018) 1.1 1.6 1.7 1.3 -1.2
Intelligence (Savage-Jansen 2018) 2.5 7.7 11.3 2.0 -3.4
Neuroticism (Nagel 2018) 0.4 1.0 2.1 1.4 0.2
Schizophrenia (2018) 0.1 0.3 0.3 -0.5 0.6
Schizophrenia vs Biploar Disorder 0.1 0.1 0.2 0.4 -0.3
Worry (Nagel 2018) 0.5 1.0 2.0 1.4 0.3
Alzheimer’s Disease (in mother) 1.1 1.2 2.1 -1.5 0.6
Alzheimer’s Disease (in father) 0.2 0.3 0.5 0.1 0.7
Alzheimer’s Disease (including proxy) 0.7 1.1 1.5 -1.2 0.8
Crohns Disease (2017) 0.7 1.5 2.7 1.6 -0.6
Irritable Bowel Disease (IBD) 0.2 0.5 1.0 1.0 -0.2
Ulcerative Colitis (UC) 0.0 0.1 0.1 0.1 0.3
Major Depression (MDD) 0.7 0.9 1.7 1.3 -0.3
Reaction Time 3.4 6.5 9.1 3.0 -2.0
Verbal and Numeric Reasoning (VNR) 2.2 5.3 6.8 2.0 -2.6
Breast Cancer 1.4 3.3 6.6 0.4 -2.6
Ovarian Cancer 0.6 0.8 1.1 -1.0 0.7
Prostate Cancer 0.1 0.1 0.1 0.3 0.2
Age at First Birth 1.7 2.5 3.4 1.3 -1.9
Bipolar Disorder (2011) 0.5 0.5 0.7 -0.6 0.8
Body Mass Index (BMI) (2010) 1.4 1.9 1.9 -1.4 1.4
Coronary Artery Disease (CAD) 0.9 1.1 1.4 -0.9 1.2
Crohns Disease (2012) 0.6 1.0 1.9 1.4 -0.4
Mean Putamen Volume 0.4 0.5 0.7 0.8 -0.5
Fasting Glucose 0.3 0.3 0.5 -0.4 -0.7
HbA1C 0.2 0.2 0.4 0.7 -0.2
HDL Cholesterol 0.3 0.4 0.6 -0.8 0.5
LDL Cholesterol 1.5 2.3 3.9 2.0 -0.9
Lupus 0.1 0.1 0.1 -0.1 -0.4
Neuroticism (2016) 1.2 1.7 2.9 1.7 -0.7
Primary Biliary Cirrhosis 0.4 0.5 1.0 1.0 -0.2
Rheumatoid Arthritis 0.0 0.0 0.0 -0.2 0.1
Schizophrenia (2014) 0.0 0.1 0.1 -0.4 -0.1
Triglycerides 0.8 1.3 1.5 1.2 1.1
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.3 0.1 -0.5
Ulcerative Colitis 0.0 0.1 0.1 0.3 -0.2
Blood Eosinophil Count 0.0 0.2 0.4 -0.7 -0.0
Blood Platelet Count 0.1 0.7 1.0 0.7 -1.0
Blood Red Count 0.0 0.5 0.6 0.8 0.6
Blood White Count 0.1 0.7 1.1 1.1 0.5
Heel T-Score 0.4 3.5 6.1 1.0 -2.5
BMI 1.1 6.6 12.8 -0.6 3.6
Height 1.6 30.1 46.8 -3.7 6.8
Waist Hip Ratio (WHR) 0.0 0.0 0.0 0.1 -0.2
Systolic Blood Pressure 0.5 2.4 3.5 1.9 -1.1
Smoking Status 0.4 1.0 1.5 -0.7 1.2
Allergy or Eczema 0.5 1.4 1.5 -1.2 1.2
Cardiovascular Disease 0.5 1.5 2.7 -0.6 1.6
Hypothyroidism (self reported) 0.2 0.4 0.7 0.8 -0.2
Respiratory disease 1.1 2.4 3.3 -1.8 1.2
Type 2 Diabetes (T2D) (2018) 0.0 0.0 0.0 -0.2 0.0
Lung FEV1/FVC ratio 0.0 0.1 0.2 0.4 0.1
Lung FVC 4.3 21.8 28.3 -5.3 3.9
Neuroticism 0.9 2.1 3.3 1.8 -0.9
Chronotype (morning person) 0.2 0.5 0.7 0.8 0.5
Hair Pigment 0.2 4.9 7.8 -2.8 -1.4
Tanning 8.3 101.6 169.0 -5.8 13.0
Hand grip strength (left) 0.3 0.9 1.7 -1.3 0.3
Number of treatments/medications taken 2.1 3.7 4.8 -1.6 2.2
Average weekly spirits intake 3.7 4.6 4.7 -2.2 2.1
Sensitivity / hurt feelings 0.6 1.0 1.0 0.9 -1.0
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.1 0.3 -0.4
Hearing difficulty/problems: Yes 0.4 0.6 0.9 -1.0 -0.5
Relative age of first facial hair 0.3 0.6 0.7 0.9 -0.7
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 1.4 1.2 -0.5
Ever used hormone-replacement therapy (HRT) 0.5 0.6 0.9 1.0 -0.5
Ever had hysterectomy (womb removed) 0.2 0.2 0.2 -0.5 -0.3
Systolic blood pressure, automated reading 0.5 1.3 1.8 1.4 -0.9
Eye problems/disorders: Diabetes related eye disease 0.7 0.7 0.9 1.0 -0.8
Angina 0.1 0.2 0.4 -0.0 0.6
Medication for hormone replacement therapy 0.2 0.2 0.5 -0.7 0.2
Vitamin and mineral supplements 0.6 0.9 1.7 1.3 0.1
Supplements: Zinc 1.6 1.7 1.9 1.4 -1.3
Medication: Co-codamol 0.8 0.9 1.3 -1.1 0.7
Medication: Metformin 0.1 0.2 0.4 0.2 -0.6
Diabetes (father) 0.9 1.1 1.3 -1.0 -1.1
Diabetes (mother) 0.7 0.8 1.5 -1.2 0.4
Severe depression (siblings) 0.6 0.7 1.4 1.2 -0.2
Pack years adult smoking proportion 0.5 0.8 0.8 0.9 -0.9
Impedance of leg (right) 1.5 7.5 11.8 1.8 -3.4
Leg fat-free mass (left) 2.1 10.9 19.6 -1.5 4.4
Trunk fat percentage 0.5 2.0 3.3 0.8 1.8
Hand grip strength (right) 0.1 0.2 0.3 -0.6 -0.0
Townsend deprivation index at recruitment 0.5 0.7 1.0 0.6 -1.0
Current tobacco smoking 0.5 0.9 1.3 -1.1 0.7
Average weekly fortified wine intake 1.8 2.1 3.6 1.9 -0.8
Maternal smoking around birth 0.1 0.1 0.1 0.1 0.4
Fed-up feelings 0.7 1.2 1.9 1.4 -0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 2.0 2.7 2.9 1.6 -1.7
Relative age voice broke 0.3 0.4 0.8 0.2 0.9
Taking other prescription medications 2.1 3.2 4.3 -1.4 2.1
Age when periods started (menarche) 0.6 1.4 1.5 1.2 -1.2
Bilateral oophorectomy (both ovaries removed) 1.9 2.2 4.1 -2.0 0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 0.7 -0.3 -0.8
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.4 0.6 0.6
Qualifications: CSEs or equivalent 0.2 0.3 0.6 -0.8 -0.1
Serious illness, injury or assault to yourself 0.3 0.4 0.4 -0.6 0.6
High blood pressure 0.1 0.2 0.4 0.1 0.6
Hayfever, allergic rhinitis or eczema 1.2 2.6 3.5 -1.3 1.9
Multivitamins +/- minerals 0.0 0.0 0.0 -0.0 -0.2
Stomach or abdominal pain in last month 0.3 0.3 0.7 0.0 0.8
Supplements: Glucosamine 0.6 0.8 1.6 -1.3 -0.2
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.2 -0.1 1.1
Medication: Atenolol 0.8 1.0 1.8 0.5 -1.4
Medication: Levothyroxine sodium 0.1 0.1 0.2 0.3 0.4
Sitting height 0.8 5.3 9.0 -1.3 3.0
Chronic bronchitis/emphysema (father) 0.3 0.3 0.6 -0.3 0.8
High blood pressure (mother) 1.2 1.6 1.8 1.2 -1.3
Body mass index (BMI) 0.9 3.6 6.8 0.7 2.6
Impedance of leg (left) 1.1 5.4 9.4 1.1 -3.1
Leg predicted mass (left) 2.0 10.6 19.2 -1.4 4.4
Trunk fat mass 1.4 6.0 11.9 0.1 3.5
Waist circumference 2.0 7.2 14.1 -0.5 3.8
Number of incorrect matches in round 0.1 0.1 0.1 0.3 -0.4
Past tobacco smoking 0.5 1.0 1.1 0.9 -1.1
Alcohol usually taken with meals 0.3 0.5 0.9 1.0 0.4
Nervous feelings 1.6 3.0 5.0 2.2 -1.0
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.6 -0.8 0.2
Hearing difficulty/problems with background noise 0.0 0.0 0.1 -0.2 0.1
Hair/balding pattern: Pattern 2 0.7 0.9 1.5 -1.2 -0.5
Had menopause 3.9 4.9 6.4 1.8 -2.5
Had other major operations 0.7 0.8 1.1 -1.0 0.7
Forced vital capacity (FVC) 5.6 21.5 23.3 -4.4 4.8
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.2 0.4 -0.7 -0.2
Ever unenthusiastic/disinterested for a whole week 0.7 0.8 1.1 -1.0 0.7
Qualifications: None of the above 1.3 2.7 5.0 -0.6 2.2
Financial difficulties in last 2 years 0.3 0.4 0.4 0.6 -0.7
Mouth/teeth dental problems 0.8 1.3 2.5 -1.6 -0.2
Heart attack 3.7 4.7 5.4 -2.3 2.0
Allergy 1.6 3.6 3.9 2.0 -1.8
Pain all over the body in last month 0.6 0.7 1.0 0.6 1.0
Diabetes (self-reported) 0.1 0.1 0.2 -0.4 0.0
Hayfever/allergic rhinitis (self-reported) 0.3 0.3 0.4 -0.6 0.5
Medication: Ramipril 0.3 0.3 0.5 -0.4 0.7
Medication: Simvastatin 1.4 2.0 3.9 -0.4 2.0
Fluid intelligence score 1.4 2.9 5.1 0.9 -2.3
Illnesses of siblings 0.7 1.0 1.8 -1.3 0.4
Neuroticism score 1.0 2.0 3.7 1.9 -0.6
Weight 2.1 10.2 20.2 -0.5 4.5
Impedance of arm (right) 0.3 1.4 2.9 -0.1 -1.7
Arm fat percentage (right) 1.0 3.8 7.1 0.7 2.7
Trunk fat-free mass 2.7 15.7 27.4 -2.0 5.2
Hip circumference 2.4 10.4 19.5 -1.1 4.4
Time employed in main current job 1.5 1.7 1.9 -1.2 1.4
Alcohol intake versus 10 years previously 1.4 2.1 3.7 -0.7 1.9
Father’s age at death 0.9 1.2 2.4 -1.6 0.0
Worrier / anxious feelings 0.2 0.4 0.8 0.9 -0.2
Frequency of tiredness / lethargy in last 2 weeks 0.0 0.0 0.1 -0.1 0.3
Falls in the last year 1.4 1.9 2.7 1.1 -1.6
Hair/balding pattern: Pattern 3 0.2 0.2 0.4 0.1 0.7
Number of live births 0.8 1.2 2.3 -1.5 0.1
Forced expiratory volume in 1-second (FEV1) 5.5 18.6 20.2 -4.1 4.5
Pulse rate 0.3 0.5 0.8 0.5 -0.9
Happiness 1.5 1.8 2.5 -1.6 1.0
Noisy workplace 0.1 0.1 0.1 -0.1 -0.3
Qualifications: A levels/AS levels or equivalent 2.6 5.8 8.8 1.6 -3.0
Serious illness, injury or assault of a close relative in last 2 years 0.0 0.0 0.1 -0.1 0.2
Mouth/teeth dental problems: Dentures 0.8 1.3 2.3 0.6 1.5
Asthma 0.2 0.3 0.6 -0.8 -0.2
Medication: Ibuprofen (e.g. Nurofen) 1.3 1.7 2.1 -1.5 1.1
Medication: Cholesterol lowering 0.3 0.5 0.9 -0.3 1.0
Depression (self-reported) 0.4 0.5 1.0 1.0 0.0
Medication: Lansoprazole 1.1 1.2 1.3 -1.1 1.1
Prospective memory result 0.2 0.3 0.6 -0.1 0.8
Lung cancer (father) 0.1 0.1 0.2 0.5 -0.1
Illnesses of mother 1.0 1.2 2.3 -0.2 -1.5
Forced expiratory volume in 1-second (FEV1), Best measure 4.9 15.7 17.7 -3.7 4.2
Pulse wave Arterial Stiffness index 0.4 0.4 0.4 -0.6 0.7
Impedance of arm (left) 0.5 2.2 4.3 -0.2 -2.1
Arm fat mass (right) 1.3 5.5 10.9 0.3 3.3
Trunk predicted mass 2.6 15.0 26.1 -2.0 5.1
Standing height 1.5 15.1 21.3 -3.0 4.6
Length of working week for main job 0.2 0.2 0.2 0.5 0.4
Exposure to tobacco smoke at home 0.3 0.3 0.4 -0.5 -0.6
Breastfed as a baby 2.6 3.2 4.7 -2.2 1.3
Tense / ‘highly strung’ 0.0 0.1 0.1 -0.2 0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 1.2 1.1 0.7
Hair/balding pattern: Pattern 4 0.3 0.8 1.0 0.8 1.0
Birth weight of first child 0.8 1.5 3.0 -0.2 1.7
Peak expiratory flow (PEF) 4.8 11.0 14.7 -2.7 3.8
Pulse wave reflection index 2.5 3.1 4.3 -2.1 1.4
Ever highly irritable/argumentative for 2 days 1.5 1.8 2.6 -1.0 1.6
Loud music exposure frequency 0.3 0.4 0.7 0.8 0.2
Qualifications: O levels/GCSEs or equivalent 1.1 1.8 3.5 -0.2 -1.9
Mouth/teeth dental problems: Bleeding gums 1.6 2.1 3.0 1.7 -1.1
Blood clot in the leg (DVT) 2.4 3.1 3.3 -1.7 1.8
Medication: Paracetamol 0.9 1.5 2.0 -1.4 1.0
Headache pain in last month 0.1 0.2 0.4 0.1 -0.6
Medication for cholesterol, blood pressure or diabetes 1.1 1.8 2.1 1.2 -1.5
Glaucoma (self-reported) 2.5 3.0 4.5 -1.2 2.1
Gout (self-reported) 0.0 0.0 0.0 0.2 -0.0
Hypothyroidism/myxoedema (self-reported) 0.1 0.1 0.2 0.5 -0.1
Medication: Amlodipine 1.7 2.4 4.2 0.8 2.0
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.7 -0.3 0.8
Birth weight 0.6 1.4 2.1 -0.8 1.4
Chronic bronchitis/emphysema (mother) 0.3 0.4 0.7 0.0 0.8
High blood pressure (siblings) 0.5 0.7 1.3 1.1 -0.0
Forced vital capacity (FVC), Best measure 7.1 25.9 28.9 -4.8 5.4
Body fat percentage 0.6 2.4 3.3 1.2 1.8
Leg fat percentage (right) 0.9 3.2 4.0 2.0 1.6
Arm fat-free mass (right) 1.5 7.9 14.2 -1.2 3.8
Exposure to tobacco smoke outside home 1.1 1.4 1.8 1.3 -1.0
Comparative body size at age 10 2.8 7.6 12.1 -1.8 3.5
Number of full brothers 0.9 1.2 1.2 1.1 -1.1
Worry too long after embarrassment 2.3 3.9 4.8 1.7 -2.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.2 0.3 -0.2 0.6
Wheeze or whistling in the chest in last year 0.2 0.4 0.7 -0.9 0.2
Number of children fathered 1.0 1.1 1.9 0.5 1.4
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 2.0 -0.0 1.4
Age at first live birth 1.1 2.0 2.5 1.6 -1.2
Pulse wave peak to peak time 0.0 0.0 0.0 0.2 -0.1
Health satisfaction 1.0 1.3 2.6 -1.6 0.2
Shortness of breath walking on level ground 0.0 0.0 0.0 0.1 0.2
Qualifications: College or University degree 0.6 1.9 3.7 -0.1 -1.9
Eye problems/disorders: None of the above 1.0 1.1 1.5 0.9 -1.2
Mouth/teeth dental problems: Loose teeth 0.2 0.3 0.4 0.4 -0.6
Emphysema/chronic bronchitis 0.5 0.5 0.6 -0.7 0.8
Medication for pain relief, constipation, heartburn 1.6 2.7 2.7 1.6 -1.6
Neck or shoulder pain in last month 1.6 2.2 2.3 -1.5 1.5
Medication: Blood pressure 1.6 2.9 3.1 -1.6 1.8
Angina (self-reported) 0.1 0.1 0.2 -0.1 0.5
Migraine (self-reported) 0.3 0.3 0.4 -0.6 0.5
Medication: Ibuprofen 0.8 0.9 1.1 -1.1 0.8
Medication: Allopurinol 0.3 0.4 0.7 -0.3 0.9
Medication: Omeprazole 2.8 3.3 5.7 -1.0 2.4
Medication: Seretide 50 evohaler 0.3 0.4 0.8 -0.9 -0.0
Mean time to correctly identify matches 3.3 6.3 8.7 2.9 -2.0
Heart disease (mother) 1.2 1.5 2.8 -0.4 1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.0 0.0 0.1 0.2 -0.1
Whole body fat mass 1.4 5.9 11.7 0.4 3.4
Leg fat mass (right) 1.4 5.2 9.7 0.9 3.1
Arm predicted mass (right) 1.8 9.3 16.8 -1.4 4.1
Pulse rate, automated reading 1.4 4.6 5.2 2.0 -2.3
Alcohol intake frequency. 0.4 0.9 1.4 0.7 1.2
Comparative height size at age 10 3.7 20.3 24.4 -4.0 4.9
Number of full sisters 0.2 0.3 0.6 0.0 -0.8
Suffer from ‘nerves’ 0.7 1.2 1.3 1.0 -1.1
Overall health rating 0.7 1.5 1.8 -1.1 1.3
Chest pain or discomfort 0.8 1.1 1.3 1.1 1.0
Had major operations 4.9 5.7 6.5 -2.2 2.5
Age at last live birth 0.4 0.5 0.7 0.6 -0.9
Family relationship satisfaction 2.6 3.1 4.1 -2.0 1.5
Leg pain on walking 1.5 1.9 3.5 -1.9 0.6
Qualifications: NVQ or HND or HNC or equivalent 1.5 1.8 2.0 1.4 -1.3
Commuting to job workplace: Car/motor vehicle 4.5 5.2 8.3 -1.5 2.9
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 1.6 0.9 -1.3
Medication: Aspirin 0.1 0.1 0.1 -0.2 0.4
Supplements: Vitamin C 8.1 9.6 12.9 -3.6 2.5
Knee pain experienced in last month 2.4 3.8 4.5 -2.1 1.7
Hypertension (Self-reported) 0.1 0.4 0.7 0.0 0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 0.8 -0.9 0.9
Illnesses of father: Heart disease 1.6 2.2 3.5 1.9 -1.0
Illnesses of siblings: Diabetes 0.3 0.3 0.4 -0.7 -0.4
Smoking status: Previous 0.8 1.2 1.8 -0.8 1.4
Forced expiratory volume in 1-second (FEV1), predicted 1.1 2.2 2.9 -1.2 1.7
Whole body fat-free mass 2.4 13.8 24.2 -1.8 4.9
Leg fat-free mass (right) 2.4 12.9 22.3 -1.9 4.7
Arm fat percentage (left) 0.8 3.3 6.2 0.6 2.5
Average weekly red wine intake 0.3 0.4 0.7 -0.9 -0.2
Handedness (chirality/laterality): Left-handed 2.4 2.8 3.9 2.0 -1.3
Mood swings 0.1 0.2 0.4 0.1 0.6
Loneliness, isolation 1.3 1.7 2.2 1.5 -1.1
Long-standing illness, disability or infirmity 0.4 0.7 1.0 1.0 -0.6
Ever had bowel cancer screening 0.1 0.2 0.2 -0.3 0.5
Diabetes diagnosed by doctor 0.0 0.0 0.0 0.2 0.0
Ever had stillbirth, spontaneous miscarriage or termination 4.6 4.9 6.5 -2.5 1.9
Friendships satisfaction 0.2 0.3 0.4 -0.5 -0.6
Qualifications: nursing, teaching 0.7 1.1 1.7 0.7 -1.3
Commuting to job workplace: Walk 0.4 0.4 0.5 -0.7 -0.6
Eye problems/disorders: Cataract 0.8 0.9 1.7 -1.3 -0.2
Mouth/teeth dental problems: Mouth ulcers 0.0 0.0 0.0 0.1 -0.0
Medication for cholesterol 0.4 0.6 1.1 -0.4 -1.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.4 2.9 5.7 0.2 2.4
Back pain experienced in last month 1.2 1.7 3.4 -0.3 1.8
Mineral and other dietary supplements 1.8 2.4 4.8 2.2 -0.2
Breast cancer (self-reported) 0.2 0.2 0.4 -0.6 0.1
Asthma (self-reported) 0.2 0.5 0.9 -1.0 0.1
Osteoporosis (self-reported) 1.4 1.8 2.7 -0.9 1.6
Osteoarthritis (self-reported) 1.5 2.0 3.1 -0.9 1.8
Medication: Aspirin 0.0 0.1 0.1 0.3 0.0
Medication: Gliclazide 0.0 0.0 0.0 0.1 -0.0
Illnesses of father: None of the above (group 1) 0.0 0.0 0.1 0.2 0.1
Smoking status: Current 0.6 0.9 1.4 -1.2 0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 6.0 12.7 15.3 -3.2 3.9
Whole body water mass 2.4 13.7 23.8 -1.9 4.9
Leg predicted mass (right) 2.5 13.3 22.8 -1.9 4.8
Arm fat mass (left) 1.3 5.3 10.6 0.3 3.2
Number of self-reported non-cancer illnesses 3.4 5.9 6.9 -2.2 2.6
Average weekly champagne plus white wine intake 1.8 2.5 4.0 2.0 -1.0
Miserableness 0.0 0.1 0.1 0.2 0.3
Guilty feelings 0.1 0.2 0.3 0.4 -0.5
Wears glasses or contact lenses 0.0 0.0 0.0 0.2 0.1
Ever taken oral contraceptive pill 0.2 0.2 0.4 0.6 -0.1
Hearing aid user 1.6 1.8 2.3 -1.1 1.5
Mother’s age at death 0.4 0.5 0.9 -0.9 0.3
Financial situation satisfaction 0.4 0.5 0.7 -0.8 0.6
Tinnitus: Yes, now most or all of the time 1.3 1.5 1.9 1.0 -1.4
Commuting to job workplace: Public transport 0.9 1.0 1.5 0.7 -1.2
Eye problems/disorders: Glaucoma 0.8 1.0 1.9 0.1 1.4
Medication: Blood pressure 0.4 0.8 1.5 1.2 -0.0
Pain type(s) experienced in last month: Hip pain 1.4 1.7 2.2 -1.5 1.1
Supplements: Fish oil (including cod liver oil) 3.1 4.1 7.7 -2.8 0.7
High cholesterol (Self-reported) 1.9 3.4 4.0 -1.7 2.0
Medication: Bendroflumethiazide 0.0 0.0 0.0 -0.1 0.1
Medication: Paracetamol 0.9 1.4 1.4 -1.2 1.2
Medication: Lisinopril 0.5 0.7 1.4 -0.2 1.2
Medication: Atorvastatin 0.4 0.5 0.8 0.3 -0.9
Illnesses of father: High blood pressure 1.4 1.8 3.0 -1.7 -0.7
Alcohol drinker status: Never 0.0 0.1 0.1 0.2 0.3
Ever smoked 0.6 1.1 1.1 -1.0 1.1
Basal metabolic rate 2.4 13.6 24.7 -1.6 5.0
Leg fat percentage (left) 0.8 2.8 3.8 1.4 1.9
Arm fat-free mass (left) 1.5 7.6 14.4 -0.9 3.8
Number of operations (self-reported) 2.2 3.3 4.8 -2.2 1.3
Average weekly beer plus cider intake 0.3 0.4 0.5 -0.6 0.7
Irritability 0.3 0.5 1.1 -0.2 1.0
Risk taking 0.6 0.9 1.3 -1.2 0.6
Ever had prostate specific antigen (PSA) test 2.3 2.6 2.8 -1.6 1.7
Fractured/broken bones in last 5 years 0.1 0.1 0.1 -0.2 0.4
Age started oral contraceptive pill 1.4 1.8 2.1 1.5 -1.2
Diastolic blood pressure, automated reading 0.2 0.5 1.1 0.0 -1.0
Ever depressed for a whole week 1.0 1.3 2.6 -1.6 0.0
Unable to work because of sickness or disability 0.4 0.5 0.6 0.6 0.8
Commuting to job workplace: Cycle 0.3 0.3 0.4 -0.5 0.7
Myopia 4.6 6.7 7.0 -2.6 2.5
Vascular/heart problems diagnosed by doctor 0.2 0.4 0.9 0.0 -0.9
Cholesterol lowering medication 0.3 0.5 0.6 0.6 0.8
Medication: Omeprazole (e.g. Zanprol) 3.7 4.5 7.2 -1.3 2.7
Pain experienced in last month 1.8 3.0 3.8 1.9 -1.5
Supplements: Calcium 0.1 0.1 0.1 -0.2 -0.3
Basal cell carcinoma (self-reported) 1.6 1.9 2.8 0.9 -1.7
Heart attack/myocardial infarction (self-reported) 3.8 4.9 5.5 -2.3 2.1
Deep venous thrombosis (DVT) (self-reported) 4.3 5.5 6.2 -2.2 2.5
Heart disease (siblings) 0.4 0.5 0.8 -0.5 0.9
Alcohol drinker status: Previous 0.4 0.5 0.9 0.3 0.9
Pack years of smoking 0.4 0.5 0.6 0.8 -0.7
Impedance of whole body 1.1 5.8 10.9 0.8 -3.3
Leg fat mass (left) 1.5 6.0 11.8 0.4 3.4
Arm predicted mass (left) 1.8 9.3 17.1 -1.2 4.1