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chr2:24,348,096-26,088,769

Best TWAS P=5.97e-15 · Best GWAS P=3.3e-15 conditioned to 0.263

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ADCY3	0.16	0.12	lasso	10	0.14	3.2e-17	-6.4	5.3	1.2e-07	0.45	0.97	0.03	FALSE
2	CommonMind	Brain Pre-frontal Cortex	DNAJC27	0.14	0.14	lasso	5	0.14	2.0e-16	-6.4	6.4	1.3e-10	0.19	0.95	0.05	FALSE
3	GTEx	Adipose Subcutaneous	ADCY3	0.07	0.04	lasso	6	0.01	3.2e-02	-5.4	-5.7	1.0e-08	-0.41	0.82	0.02	FALSE
4	GTEx	Adipose Subcutaneous	RP11-443B20.1	0.04	0.00	enet	10	0.00	1.2e-01	-5.9	-5.9	3.1e-09	-0.38	0.36	0.06	FALSE
5	GTEx	Artery Coronary	DNAJC27	0.12	0.03	lasso	7	0.00	2.4e-01	-6.7	-7.8	6.0e-15	-0.37	0.16	0.13	TRUE
6	GTEx	Artery Tibial	RP11-443B20.1	0.17	0.08	enet	40	0.09	8.2e-08	-4.4	-5.3	1.1e-07	-0.38	0.91	0.02	FALSE
7	GTEx	Cells EBV-transformed lymphocytes	ADCY3	0.25	0.23	enet	10	0.12	9.2e-05	-5.4	5.6	2.0e-08	0.49	0.70	0.13	FALSE
8	GTEx	Cells EBV-transformed lymphocytes	RP11-443B20.1	0.13	0.13	enet	9	0.05	9.2e-03	-5.4	6.1	1.2e-09	0.49	0.32	0.14	FALSE
9	GTEx	Esophagus Mucosa	ADCY3	0.06	0.05	lasso	3	0.03	6.8e-03	-6.7	-6.6	3.9e-11	-0.19	0.58	0.06	FALSE
10	GTEx	Nerve Tibial	ADCY3	0.09	0.05	enet	6	0.03	2.2e-03	-4.4	5.8	8.0e-09	0.46	0.94	0.03	FALSE
11	GTEx	Whole Blood	DNAJC27	0.08	0.10	lasso	1	0.10	2.2e-09	-5.5	-5.5	4.8e-08	-0.39	1.00	0.00	FALSE
12	GTEx	Whole Blood	ADCY3	0.23	0.24	enet	24	0.27	5.5e-25	-5.5	-5.4	7.7e-08	-0.43	1.00	0.00	FALSE
13	GTEx	Whole Blood	RP11-443B20.1	0.21	0.17	enet	32	0.20	1.8e-18	-5.5	-5.3	1.0e-07	-0.47	1.00	0.00	FALSE
14	ROSMAP	Brain Pre-frontal Cortex	DNAJC27	0.10	0.06	blup	330	0.06	3.7e-08	-6.6	6.9	5.2e-12	0.18	0.93	0.07	FALSE
15	ROSMAP	Brain Pre-frontal Cortex	ADCY3	0.17	0.26	enet	32	0.26	6.8e-33	-5.5	6.4	1.6e-10	0.41	1.00	0.00	FALSE
16	YFS	Blood	DNAJC27	0.07	0.04	blup	333	0.05	3.1e-17	-6.6	6.1	1.1e-09	0.33	0.94	0.06	FALSE
17	YFS	Blood	POMC	0.35	0.05	enet	71	0.19	5.7e-59	7.9	5.3	1.1e-07	0.64	0.00	1.00	FALSE
18	The Cancer Genome Atlas	Breast Invasive Carcinoma	DNAJC27	0.04	0.01	enet	8	0.02	6.8e-05	1.7	5.6	2.0e-08	0.24	0.05	0.75	FALSE
19	The Cancer Genome Atlas	Breast Invasive Carcinoma	POMC	0.08	0.05	lasso	3	0.06	2.6e-12	3.2	5.4	6.0e-08	0.64	0.65	0.35	FALSE
20	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	POMC	0.06	0.00	enet	12	0.03	9.3e-05	3.2	7.1	1.1e-12	0.59	0.01	0.60	TRUE
21	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EFR3B	0.03	0.05	lasso	1	0.04	1.9e-05	6.7	6.7	2.8e-11	0.73	0.09	0.85	FALSE
22	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	POMC	0.16	0.05	blup	39	0.11	2.4e-12	7.9	6.0	1.7e-09	0.62	0.00	1.00	FALSE
23	The Cancer Genome Atlas	Brain Lower Grade Glioma	ADCY3	0.03	0.02	blup	81	0.02	7.1e-04	-5.2	6.8	1.1e-11	0.42	0.08	0.85	FALSE
24	The Cancer Genome Atlas	Lung Adenocarcinoma	DNAJC27	0.05	0.01	blup	46	0.04	3.2e-05	-6.6	7.5	7.9e-14	0.35	0.02	0.98	FALSE
25	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	DNAJC27	0.04	0.04	lasso	1	0.02	1.2e-02	-6.5	6.5	8.4e-11	0.19	0.02	0.78	FALSE
26	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	POMC	0.19	0.01	blup	38	0.05	1.5e-04	7.9	6.8	7.6e-12	0.78	0.00	0.84	FALSE
27	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	DNAJC27	0.12	0.12	lasso	2	0.09	1.7e-04	-6.5	6.5	8.9e-11	0.19	0.02	0.97	FALSE
28	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	DNAJC27	0.07	0.09	lasso	2	0.10	8.2e-05	-6.5	6.5	8.9e-11	0.19	0.02	0.91	FALSE
29	The Cancer Genome Atlas	Prostate Adenocarcinoma	DNAJC27	0.07	0.03	enet	13	0.06	1.3e-06	-6.5	6.2	7.0e-10	0.23	0.02	0.98	FALSE
30	The Cancer Genome Atlas	Prostate Adenocarcinoma	POMC	0.11	0.08	enet	7	0.09	1.6e-09	3.2	5.6	2.0e-08	0.67	0.14	0.86	FALSE
31	The Cancer Genome Atlas	Thyroid Carcinoma	DNAJC27	0.07	0.01	enet	5	0.04	6.8e-05	-6.6	5.7	1.3e-08	0.21	0.02	0.70	FALSE