[Hub]/) : Traits : Alzheimer’s Disease (in father) :

chr19:44,190,626-46,680,895

Best TWAS P=2.68e-30 · Best GWAS P=8.26e-193 conditioned to 2.42e-22

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Visceral Omentum ZNF285 0.17 0.05 enet 20 0.07 1.3e-04 -0.39 -7.7 1.1e-14 -0.17 0.39 0.15 TRUE
2 GTEx Nerve Tibial ERCC1 0.21 0.09 enet 47 0.10 2.1e-07 1.33 -6.8 9.4e-12 -0.15 0.61 0.08 TRUE
3 GTEx Skin Not Sun Exposed Suprapubic ZNF229 0.28 0.09 enet 58 0.08 2.2e-05 -1.50 -9.6 1.3e-21 -0.27 0.10 0.47 FALSE
4 GTEx Thyroid CEACAM19 0.34 0.28 enet 26 0.30 9.9e-24 4.82 6.8 1.4e-11 0.09 1.00 0.00 TRUE
5 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma APOC1P1 0.05 0.03 blup 37 0.03 5.2e-04 -7.28 9.7 2.1e-22 0.22 0.14 0.20 TRUE
6 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma TOMM40 0.04 0.03 lasso 2 0.02 1.4e-03 -11.48 11.4 2.7e-30 0.22 0.12 0.09 TRUE
7 The Cancer Genome Atlas Lung Squamous Cell Carcinoma APOC1 0.05 0.00 blup 47 0.01 4.3e-02 -1.36 -10.4 4.0e-25 -0.32 0.01 0.06 TRUE
8 The Cancer Genome Atlas Lung Squamous Cell Carcinoma APOE 0.06 0.00 blup 49 0.01 4.5e-02 -1.36 -8.6 9.6e-18 -0.29 0.02 0.06 TRUE
9 The Cancer Genome Atlas Prostate Adenocarcinoma TOMM40 0.08 0.07 enet 13 0.07 2.2e-07 -11.48 6.8 1.4e-11 0.14 1.00 0.00 TRUE
10 The Cancer Genome Atlas Testicular Germ Cell Tumors APOC1P1 0.14 0.01 blup 36 0.06 3.8e-03 -0.47 6.6 3.9e-11 0.20 0.01 0.07 FALSE
11 The Cancer Genome Atlas Thyroid Carcinoma PVRL2 0.09 0.05 blup 55 0.03 4.6e-04 -0.85 -6.4 1.6e-10 -0.05 0.48 0.05 TRUE
12 The Cancer Genome Atlas Thyroid Carcinoma TOMM40 0.05 0.07 lasso 3 0.06 1.1e-06 -9.67 9.2 2.8e-20 0.19 0.89 0.01 TRUE
13 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma APOC2 0.20 0.14 enet 10 0.14 7.9e-05 1.75 -5.5 4.1e-08 -0.08 0.15 0.05 TRUE