Hub : Genes

ERCC1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.2093	0.0640	1.8e-04	0.091	NA	0.098	NA	0.083	5.6e-07	NA	2.1e-07	NA	1.6e-06
2	GTEx	Skin Sun Exposed Lower leg	0.1690	0.0560	1.4e-03	0.136	NA	0.138	NA	0.143	2.2e-11	NA	1.8e-11	NA	6.5e-12
3	GTEx	Testis	0.4660	0.0890	1.8e-07	0.319	NA	0.246	NA	0.271	9.9e-15	NA	2.9e-11	NA	2.0e-12
4	GTEx	Thyroid	0.2230	0.0560	1.3e-05	0.142	NA	0.142	NA	0.129	5.0e-11	NA	5.8e-11	NA	4.6e-10
5	YFS	Blood	0.0795	0.0165	9.6e-12	0.047	0.051	0.065	0.057	0.063	4.0e-15	2.7e-16	2.5e-20	6.3e-18	9.8e-20
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0708	0.0300	2.7e-04	0.049	0.038	0.032	NA	0.042	3.0e-06	3.7e-05	1.6e-04	NA	1.5e-05
7	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1130	0.0520	3.3e-03	0.079	0.049	0.068	NA	0.068	2.8e-05	8.9e-04	9.3e-05	NA	9.4e-05
8	TCGA	Pheochromocytoma and Paraganglioma	0.2360	0.0930	7.1e-04	0.123	0.090	0.080	NA	0.095	1.4e-05	1.9e-04	4.3e-04	NA	1.3e-04
9	TCGA	Prostate Adenocarcinoma	0.0867	0.0291	1.6e-06	0.074	0.070	0.064	NA	0.068	3.8e-08	7.9e-08	2.8e-07	NA	1.3e-07
10	TCGA	Soft Tissue Sarcoma	0.1150	0.0560	6.2e-03	0.045	0.024	0.019	NA	0.031	1.1e-03	1.4e-02	2.7e-02	NA	5.6e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	1.0	1.6	2.7	-1.4	-1.3	0.4	-0.9	-1.6	-1.3	-0.9	-1.6	-1.4	-1.5
Bipolar Disorder or Schizophrenia	1.1	2.8	5.9	-2.0	-1.5	0.5	-1.2	-1.8	-2.1	-0.5	-2.4	-2.0	-1.5
Depressed Affect (Nagel 2018)	0.9	1.9	4.7	-0.2	1.3	-0.3	1.1	1.5	1.6	2.2	1.8	1.4	1.3
Depression (Nagel 2018)	1.4	2.1	6.0	0.2	2.2	-0.3	0.8	1.5	1.1	2.5	1.2	0.8	2.1
Intelligence (Savage-Jansen 2018)	1.5	4.6	10.0	0.6	-1.9	2.1	-1.9	-2.5	-1.9	-3.2	-2.2	-2.0	-2.3
Neuroticism (Nagel 2018)	0.8	1.9	3.8	0.6	1.2	-0.5	1.2	1.7	1.6	2.0	1.7	1.3	1.2
Schizophrenia (2018)	0.6	1.3	3.3	-1.5	-0.9	0.1	-0.7	-0.9	-1.6	0.0	-1.8	-1.4	-0.8
Schizophrenia vs Biploar Disorder	0.9	1.2	4.9	0.0	0.0	-2.0	2.2	1.7	0.0	0.0	0.0	0.0	0.0
Worry (Nagel 2018)	0.1	0.2	0.4	-0.1	0.4	0.2	-0.1	0.6	0.6	0.5	0.5	-0.2	0.3
Alzheimer’s Disease (in mother)	0.7	0.8	3.1	0.1	-1.8	-0.1	0.2	-0.1	0.0	-1.4	-0.1	0.1	-1.6
Alzheimer’s Disease (in father)	6.1	6.6	46.5	-6.8	-1.1	0.9	-1.8	-1.5	-1.4	-1.6	-1.8	-1.7	-1.3
Alzheimer’s Disease (including proxy)	1.4	2.0	6.8	-0.0	-2.6	-0.4	-0.7	-0.6	-0.6	-2.1	-0.9	-1.0	-2.4
Crohns Disease (2017)	0.3	0.7	1.2	0.3	-1.1	-0.6	1.0	-0.1	-0.8	-0.9	-1.1	-0.9	-0.8
Irritable Bowel Disease (IBD)	0.1	0.3	1.1	0.2	-0.7	-1.1	0.8	0.6	-0.2	0.6	-0.4	-0.3	-0.3
Ulcerative Colitis (UC)	0.2	0.4	2.2	0.4	0.2	-0.8	0.0	0.7	0.1	1.5	0.0	0.2	0.4
Major Depression (MDD)	2.0	2.4	5.1	-1.4	-1.5	-0.9	0.1	-1.5	-2.0	-1.7	-2.3	-1.8	-1.2
Reaction Time	0.5	1.0	2.1	-0.2	0.4	-1.1	1.3	1.3	1.4	0.9	1.4	0.5	0.6
Verbal and Numeric Reasoning (VNR)	0.3	0.8	2.6	1.3	-0.4	1.0	0.2	-0.9	-0.6	-1.6	-1.0	-0.4	-0.6
Breast Cancer	0.6	1.5	4.3	-1.1	-2.1	0.5	-0.8	-0.7	-0.6	-1.5	-0.5	-0.7	-2.1
Ovarian Cancer	1.1	1.4	3.7	-0.0	-1.1	1.4	-0.9	-1.3	-0.5	-1.9	-0.4	-1.6	-1.3
Prostate Cancer	0.4	0.6	2.8	0.0	1.7	0.1	0.2	0.2	-0.1	0.8	0.1	-0.3	1.6
Age at First Birth	0.3	0.4	1.0	0.2	0.9	0.8	-0.4	0.7	0.7	0.3	1.0	0.0	0.6
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.6	0.9	1.9	0.8	-1.1	-1.4	0.5	0.8	1.0	0.3	1.2	0.9	-0.7
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.1	0.1	0.3	-0.3	-0.2	-0.6	0.5	0.4	0.2	-0.1	0.1	0.1	-0.1
Mean Putamen Volume	1.2	1.3	3.4	0.5	1.8	-0.1	0.4	1.3	1.0	1.6	1.1	0.3	1.8
Fasting Glucose	0.7	0.8	2.1	0.3	0.1	-1.4	0.9	1.5	1.0	1.4	0.5	0.4	0.4
HbA1C	1.0	1.1	6.4	-2.5	0.3	0.8	-0.2	-0.4	-1.0	-0.4	-0.8	-1.2	0.1
HDL Cholesterol	1.0	1.7	2.9	1.7	-0.6	1.2	-0.7	-0.9	-1.4	-1.6	-1.7	-1.6	-0.9
LDL Cholesterol	1.8	2.9	19.5	-4.4	-2.0	-0.3	-0.3	0.2	0.8	-0.5	0.7	0.8	-1.9
Lupus	1.5	2.3	6.6	-1.1	0.2	1.8	-1.4	-1.5	-1.7	-1.2	-1.8	-2.6	-0.2
Neuroticism (2016)	0.2	0.3	0.9	0.1	0.9	0.0	0.1	0.6	-0.5	0.2	-0.3	-0.5	0.9
Primary Biliary Cirrhosis	0.1	0.2	0.5	0.7	-0.1	0.3	-0.6	-0.5	-0.5	-0.1	-0.3	-0.2	-0.2
Rheumatoid Arthritis	0.3	0.4	1.3	-1.2	0.7	0.9	-0.5	0.1	0.1	-0.4	0.1	-0.7	0.4
Schizophrenia (2014)	0.9	2.0	4.8	-1.7	-0.4	0.6	-0.9	-1.5	-2.0	-0.7	-2.2	-2.0	-0.6
Triglycerides	0.7	1.1	7.6	-2.8	0.6	-0.8	0.2	0.7	0.6	1.0	0.5	0.2	0.7
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.4	0.6	2.8	-1.7	-0.3	-0.0	-1.2	0.3	0.5	1.1	0.4	0.2	-0.3
Blood Eosinophil Count	1.4	10.8	16.5	2.3	-1.9	3.5	-2.9	-2.9	-4.0	-4.1	-4.0	-3.9	-2.6
Blood Platelet Count	4.0	46.0	146.4	12.1	1.8	-5.5	8.3	6.9	6.0	3.6	5.6	8.6	3.0
Blood Red Count	0.2	1.9	5.5	-1.7	2.3	0.1	0.7	0.7	-0.4	2.1	-0.3	-0.7	2.2
Blood White Count	0.4	3.3	11.6	3.4	1.2	-1.0	2.4	2.4	0.8	1.6	0.4	1.2	1.4
Heel T-Score	1.2	9.2	34.2	-2.0	-5.8	0.3	-2.5	-2.1	-0.4	-3.6	-0.5	-0.4	-5.5
BMI	0.1	0.6	3.2	1.8	0.3	-0.8	0.4	0.9	-0.3	0.7	-0.4	0.3	0.5
Height	0.0	1.0	2.3	0.6	-1.2	-1.5	0.4	0.3	1.1	-0.1	1.1	1.5	-0.8
Waist Hip Ratio (WHR)	0.3	1.6	2.9	1.1	-1.7	-0.4	1.1	-0.5	-1.1	-1.4	-1.4	-1.6	-1.4
Systolic Blood Pressure	0.1	0.4	1.4	-1.2	-0.8	-1.2	-0.3	-0.1	0.0	-0.0	-0.1	-0.3	-0.4
Smoking Status	0.3	0.7	2.2	0.2	-0.8	-0.6	0.6	0.3	0.7	1.5	0.4	1.5	-0.5
Allergy or Eczema	0.4	1.1	2.4	-0.9	-0.5	1.5	-0.6	-1.2	-1.0	-1.3	-1.0	-1.1	-0.8
Cardiovascular Disease	0.6	2.0	8.9	-3.0	-2.3	-0.9	-1.0	0.2	-0.1	-0.9	-0.3	-0.5	-1.9
Hypothyroidism (self reported)	0.3	0.6	1.6	0.1	1.0	-0.9	1.3	0.6	0.4	0.8	0.5	0.5	1.1
Respiratory disease	1.3	2.9	5.3	-1.1	-0.7	1.3	-2.0	-2.2	-2.1	-1.3	-2.1	-2.3	-1.0
Type 2 Diabetes (T2D) (2018)	1.4	2.7	5.2	-1.9	-1.6	2.0	-2.3	-1.7	-0.3	-1.2	-0.3	-1.7	-2.0
Lung FEV1/FVC ratio	0.1	0.5	2.0	0.6	-0.8	-1.4	1.0	1.0	0.2	-0.5	0.2	0.1	-0.4
Lung FVC	0.1	0.3	0.8	-0.4	0.8	0.9	-0.2	-0.3	0.1	0.8	-0.0	0.6	0.5
Neuroticism	1.0	2.3	4.8	0.1	1.2	-0.4	0.6	2.2	1.9	2.2	2.0	1.4	1.3
Chronotype (morning person)	0.5	1.2	3.1	0.5	-1.8	-0.5	0.7	-0.9	-1.1	-1.4	-1.3	0.3	-1.5
Hair Pigment	0.1	2.5	5.3	-2.3	1.9	2.2	-2.2	-0.3	-1.0	0.3	-0.7	-1.7	1.2
Tanning	0.1	1.3	4.3	-2.1	-1.6	0.7	-0.7	-1.4	-0.4	-0.4	-0.4	-0.0	-1.7
Hand grip strength (left)	0.4	1.1	2.6	0.8	-1.6	-0.5	0.2	0.3	1.2	-0.8	1.1	1.4	-1.4
Number of treatments/medications taken	0.3	0.5	1.3	-0.4	-0.5	-1.0	-0.0	0.8	0.9	0.5	0.9	1.1	-0.3
Average weekly spirits intake	0.5	0.6	1.3	-0.8	0.3	0.7	-1.1	-1.0	-0.9	-0.4	-0.8	-0.8	0.1
Sensitivity / hurt feelings	1.3	2.2	5.5	-0.2	2.0	-0.1	0.2	1.6	1.4	2.4	1.8	1.3	1.9
Frequency of depressed mood in last 2 weeks	2.1	2.9	7.8	0.9	2.7	-0.7	0.4	1.9	0.8	2.7	1.0	0.5	2.8
Hearing difficulty/problems: Yes	0.6	0.9	3.1	-1.8	-0.2	0.1	-0.0	-0.4	-1.4	-0.9	-1.5	-0.7	-0.2
Relative age of first facial hair	0.6	1.3	6.7	-2.6	0.3	1.8	-1.3	-0.5	-0.3	-0.4	-0.0	-0.9	-0.2
Other serious medical condition/disability diagnosed by doctor	0.7	1.0	2.0	1.1	1.1	-0.9	1.2	1.4	0.4	1.0	0.6	0.3	1.3
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.6	-0.5	0.1	-0.4	0.0	0.0	-0.7	0.4	-0.8	0.3	0.2
Ever had hysterectomy (womb removed)	0.3	0.3	0.6	-0.5	-0.3	0.6	-0.5	-0.7	-0.7	-0.2	-0.8	-0.6	-0.4
Systolic blood pressure, automated reading	0.1	0.3	0.7	-0.5	0.3	-0.5	-0.1	0.6	0.7	0.9	0.8	0.3	0.4
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	3.4	-1.8	-1.2	0.6	-1.1	-1.3	-1.2	-1.1	-1.1	-1.8	-1.2
Angina	0.6	0.8	4.6	-0.1	-0.3	-1.4	2.1	1.0	0.2	0.4	0.3	0.4	0.1
Medication for hormone replacement therapy	3.1	3.4	6.6	1.5	1.7	-2.3	2.6	1.8	0.3	2.0	0.6	2.1	2.2
Vitamin and mineral supplements	0.5	0.6	2.4	-0.5	-1.5	0.4	-0.4	-0.5	-0.1	-0.8	-0.4	0.2	-1.5
Supplements: Zinc	0.1	0.1	0.6	-0.0	-0.2	-0.1	-0.1	-0.1	-0.2	0.0	-0.0	-0.8	-0.1
Medication: Co-codamol	0.4	0.5	2.2	0.2	-1.5	-1.0	0.3	-0.2	-0.4	-0.1	-0.7	-0.1	-1.1
Medication: Metformin	0.8	1.2	4.0	-1.0	-0.7	1.4	-0.9	-1.2	-0.4	-0.7	-0.5	-2.0	-1.0
Diabetes (father)	0.8	1.0	4.3	-2.1	-0.3	-0.1	0.1	-0.7	-1.3	-0.6	-1.1	-1.2	-0.3
Diabetes (mother)	1.3	1.7	3.9	-1.7	0.7	1.2	-1.1	-0.8	-1.8	-0.3	-1.7	-2.0	0.4
Severe depression (siblings)	1.1	1.2	3.2	-0.5	1.8	0.3	-0.0	0.7	0.7	1.8	0.9	1.1	1.6
Pack years adult smoking proportion	0.6	0.8	3.2	-1.8	-0.7	0.1	-0.0	-0.8	-1.2	-0.7	-1.1	-0.7	-0.6
Impedance of leg (right)	0.2	0.8	2.3	-0.0	-1.0	0.6	-0.8	-0.7	-0.8	-1.0	-0.8	-1.5	-1.1
Leg fat-free mass (left)	0.0	0.2	0.8	0.4	-0.9	-0.7	0.2	-0.2	0.1	-0.1	0.1	0.4	-0.6
Trunk fat percentage	0.1	0.3	0.6	0.2	-0.6	0.5	-0.4	-0.2	-0.7	-0.6	-0.8	-0.6	-0.7
Hand grip strength (right)	0.2	0.6	1.9	0.2	-1.4	-0.3	-0.4	-0.4	0.7	-0.9	0.7	0.7	-1.2
Townsend deprivation index at recruitment	0.9	1.2	3.4	-1.4	0.7	0.1	-0.8	-0.3	-1.9	0.2	-1.6	-1.6	0.6
Current tobacco smoking	0.3	0.5	1.8	-1.2	0.1	-0.2	-0.3	-0.3	-0.7	1.3	-0.6	-0.7	0.2
Average weekly fortified wine intake	0.2	0.2	0.9	0.4	0.2	0.9	-0.1	-0.0	0.2	-0.5	0.2	-0.6	-0.0
Maternal smoking around birth	1.1	1.6	6.3	-0.4	0.6	-2.5	0.9	1.3	-0.3	1.7	-0.5	1.4	1.1
Fed-up feelings	0.2	0.4	1.4	-1.2	0.9	0.4	0.1	0.1	-0.2	0.9	0.0	-0.2	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	4.9	-0.3	2.2	0.2	0.4	1.0	-0.3	1.6	-0.2	0.0	2.0
Relative age voice broke	1.7	2.6	6.2	-2.5	-0.5	1.9	-1.5	-1.6	-1.6	-1.7	-1.4	-1.8	-1.0
Taking other prescription medications	0.6	0.9	3.8	2.0	0.5	-0.5	1.1	0.7	0.9	0.4	0.8	1.1	0.6
Age when periods started (menarche)	0.8	1.9	3.6	-1.7	-0.4	1.9	-1.6	-1.6	-1.1	-1.3	-1.2	-1.4	-0.9
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.1	-0.7	-1.1	-0.4	-0.1	0.2	0.6	0.2	0.5	0.4	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	7.0	-1.8	-2.6	-0.8	-0.7	-0.8	-0.1	-1.8	-0.2	-0.1	-2.2
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	2.7	-0.7	0.1	0.7	-1.6	-0.9	-0.5	0.4	-0.5	-0.3	-0.2
Qualifications: CSEs or equivalent	0.4	0.6	4.7	-2.2	0.1	0.5	-0.9	0.1	0.0	-0.2	-0.0	-0.2	0.0
Serious illness, injury or assault to yourself	0.5	0.6	1.3	-0.7	0.5	0.9	-0.6	-0.7	-1.1	-0.5	-1.0	-1.0	0.2
High blood pressure	0.3	0.7	2.2	-1.5	-1.4	-0.2	-0.7	0.0	0.3	-0.9	0.2	-0.1	-1.3
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.7	-1.1	-0.2	1.3	-0.4	-0.9	-0.8	-1.3	-0.7	-1.0	-0.5
Multivitamins +/- minerals	0.1	0.2	0.4	0.6	0.6	-0.1	0.1	0.1	-0.5	0.1	-0.4	-0.5	0.6
Stomach or abdominal pain in last month	0.6	0.7	3.0	0.9	1.0	-0.7	1.7	0.2	-0.7	-0.1	-0.6	0.3	1.1
Supplements: Glucosamine	0.4	0.5	1.3	0.1	1.1	0.4	0.3	-0.4	-1.0	0.1	-1.1	-0.6	0.9
Diverticular disease/diverticulitis (self-reported)	1.0	1.1	2.1	0.9	1.1	-0.6	0.8	1.1	1.3	0.8	1.4	1.2	1.1
Medication: Atenolol	1.9	2.4	7.3	-1.7	-2.7	0.4	-0.9	-1.5	-0.7	-1.3	-0.8	-0.3	-2.6
Medication: Levothyroxine sodium	0.1	0.1	0.5	-0.3	0.3	0.0	0.7	0.0	0.3	0.1	0.4	-0.1	0.3
Sitting height	0.4	2.9	7.4	-0.1	-1.7	0.6	-1.1	-2.3	-1.6	-2.0	-1.5	-2.7	-1.7
Chronic bronchitis/emphysema (father)	0.2	0.3	1.1	-0.4	0.8	0.0	-0.2	0.1	0.0	1.1	0.1	0.3	0.7
High blood pressure (mother)	0.9	1.2	3.8	-0.8	-1.9	0.2	-1.4	-0.5	0.8	-0.7	0.9	0.4	-1.9
Body mass index (BMI)	0.3	1.1	2.3	1.2	-0.3	-1.5	1.2	1.5	0.7	0.9	0.6	1.5	0.1
Impedance of leg (left)	0.1	0.6	1.6	0.4	-0.8	0.7	-0.7	-0.5	-0.6	-1.0	-0.5	-1.3	-0.9
Leg predicted mass (left)	0.0	0.2	0.7	0.4	-0.8	-0.8	0.3	-0.1	0.2	-0.1	0.1	0.4	-0.6
Trunk fat mass	0.1	0.2	0.6	0.6	-0.8	-0.0	-0.0	-0.0	-0.4	-0.6	-0.5	-0.2	-0.7
Waist circumference	0.1	0.5	1.5	1.2	-0.7	-0.9	0.9	0.9	0.3	0.3	0.1	0.5	-0.4
Number of incorrect matches in round	0.2	0.4	2.1	-1.5	0.5	-0.6	-0.2	0.5	-0.1	0.6	-0.1	-0.2	0.6
Past tobacco smoking	0.3	0.5	1.7	-0.3	1.2	0.5	0.1	-0.0	-0.1	-0.2	0.0	-1.3	1.0
Alcohol usually taken with meals	0.4	0.6	1.5	1.2	-0.6	-1.1	1.2	0.5	0.7	-0.3	0.7	0.7	-0.3
Nervous feelings	0.7	1.3	3.6	-1.9	0.5	1.6	-1.6	-0.5	-0.8	-0.0	-0.5	-1.6	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	1.0	0.2	0.6	-0.4	1.0	0.8	0.5	0.9	0.4	-0.1	0.7
Hearing difficulty/problems with background noise	0.5	0.9	2.5	-0.1	0.5	-1.6	1.1	1.3	0.1	0.7	-0.0	1.3	0.9
Hair/balding pattern: Pattern 2	0.3	0.4	1.1	-0.9	-0.8	0.6	-0.0	-0.3	-0.1	-1.1	-0.1	0.4	-0.9
Had menopause	0.2	0.3	0.8	0.9	0.7	0.7	-0.2	0.0	0.0	0.4	-0.1	0.8	0.5
Had other major operations	0.5	0.6	1.9	1.0	0.3	1.4	-0.1	-1.1	-0.6	-0.7	-0.5	-0.6	-0.1
Forced vital capacity (FVC)	0.6	2.2	4.9	-0.9	-1.4	1.6	-1.3	-2.2	-1.4	-1.6	-1.5	-0.9	-1.7
Heel bone mineral density (BMD) T-score, automated (right)	2.2	5.1	12.2	-2.4	-3.5	0.3	-2.0	-2.0	-1.4	-2.9	-1.3	-1.4	-3.3
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.6	-0.9	0.0	0.6	-0.2	-0.3	-0.6	-0.5	-0.6	-1.2	-0.1
Qualifications: None of the above	0.1	0.2	0.5	-0.6	-0.5	-0.3	0.1	-0.0	-0.7	0.5	-0.5	0.7	-0.4
Financial difficulties in last 2 years	1.5	2.0	4.7	-0.1	0.9	-2.1	2.2	1.5	0.9	1.9	1.0	0.8	1.3
Mouth/teeth dental problems	0.8	1.2	5.1	2.3	0.0	-1.0	1.5	1.0	0.6	0.2	0.4	1.2	0.3
Heart attack	0.3	0.4	1.3	-0.5	-0.8	-1.1	0.9	0.0	-0.3	-0.0	-0.3	0.2	-0.5
Allergy	1.2	2.9	6.0	1.8	0.6	-2.5	1.3	2.1	1.5	2.1	1.3	1.8	1.1
Pain all over the body in last month	0.3	0.3	1.3	-0.3	-1.1	-0.6	0.3	-0.1	-0.1	-0.3	-0.0	0.1	-0.9
Diabetes (self-reported)	1.7	2.6	4.8	-2.1	-1.4	2.2	-1.2	-1.9	-0.5	-1.3	-0.4	-2.1	-1.8
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.5	-0.3	-0.5	0.5	-0.1	-0.4	-0.0	-0.7	0.0	-0.2	-0.6
Medication: Ramipril	1.5	1.9	7.6	-0.5	-2.8	0.0	-1.2	-1.0	-0.2	-1.2	-0.3	-0.5	-2.6
Medication: Simvastatin	1.6	2.4	13.2	-3.6	-1.9	0.6	-0.9	-0.5	0.1	-1.2	0.1	-0.6	-1.9
Fluid intelligence score	0.1	0.3	0.8	0.9	-0.2	0.4	0.8	-0.3	0.2	-0.9	-0.1	0.4	-0.3
Illnesses of siblings	0.2	0.3	0.8	0.9	0.6	-0.1	0.2	0.5	0.6	0.4	0.5	0.5	0.5
Neuroticism score	0.5	1.1	2.7	-0.8	1.2	0.1	-0.1	1.4	1.0	1.7	1.1	0.5	1.2
Weight	0.1	0.7	1.7	1.1	-1.0	-1.3	0.9	0.7	0.5	0.1	0.4	0.9	-0.6
Impedance of arm (right)	1.9	8.8	18.2	-2.3	-0.8	3.8	-3.4	-3.2	-3.1	-2.7	-2.8	-4.3	-1.7
Arm fat percentage (right)	0.2	0.6	1.2	0.1	-1.1	0.2	-0.8	-0.3	-1.1	-0.7	-1.1	-0.7	-1.1
Trunk fat-free mass	0.2	1.1	3.1	1.1	-1.1	-1.8	1.2	0.6	1.0	0.1	0.9	1.3	-0.6
Hip circumference	0.3	1.2	2.9	1.2	-0.5	-1.7	1.2	1.2	0.8	1.1	0.7	1.5	-0.0
Time employed in main current job	0.3	0.4	1.0	-0.5	-1.0	-0.1	-0.7	0.3	0.7	-0.3	0.6	-0.1	-0.9
Alcohol intake versus 10 years previously	1.1	1.6	8.8	-3.0	-0.3	1.6	-1.6	-0.8	-0.0	-0.6	-0.1	-0.0	-0.7
Father’s age at death	1.8	2.4	10.1	3.2	0.9	-1.7	1.5	0.9	0.8	1.5	0.6	1.6	1.3
Worrier / anxious feelings	0.8	1.6	4.0	0.6	1.0	-0.7	0.7	2.0	1.6	1.3	1.7	0.8	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	3.2	0.1	1.0	-1.3	1.3	1.8	0.8	1.8	0.9	0.5	1.3
Falls in the last year	0.7	0.9	3.2	0.1	1.8	0.1	0.6	0.4	-0.8	0.7	-0.5	-1.0	1.7
Hair/balding pattern: Pattern 3	0.1	0.2	0.5	-0.6	0.3	0.7	-0.6	-0.3	0.2	-0.1	0.4	-0.4	0.0
Number of live births	0.4	0.5	1.6	-1.3	0.2	-0.7	0.6	0.4	0.5	1.2	0.4	1.0	0.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.3	-0.6	-1.1	0.5	-0.6	-1.1	-0.8	-0.9	-0.8	-0.1	-1.1
Pulse rate	0.2	0.4	2.4	1.6	0.1	-0.2	0.4	0.9	0.5	-0.2	0.4	0.0	0.1
Happiness	0.4	0.5	1.1	0.3	1.1	0.3	-0.7	0.9	0.2	0.8	0.4	-0.8	0.9
Noisy workplace	0.8	1.0	2.7	-0.9	0.7	-1.1	0.1	1.7	0.9	1.2	1.1	0.8	0.9
Qualifications: A levels/AS levels or equivalent	0.4	0.9	4.7	2.2	-0.6	-0.4	0.8	-0.5	-0.6	-1.2	-0.9	-0.3	-0.4
Serious illness, injury or assault of a close relative in last 2 years	2.4	2.8	7.4	-0.8	-0.7	1.0	-1.6	-1.8	-2.7	-1.1	-2.7	-1.9	-0.8
Mouth/teeth dental problems: Dentures	1.5	2.6	4.8	-2.2	-1.0	2.2	-2.2	-2.2	-0.9	-0.8	-0.8	-1.2	-1.5
Asthma	0.4	0.8	1.9	-1.0	-0.1	0.9	-0.3	-1.2	-1.0	-0.9	-0.9	-1.4	-0.3
Medication: Ibuprofen (e.g. Nurofen)	1.9	2.5	9.1	0.3	1.2	-3.0	0.9	1.9	0.1	2.1	0.3	1.1	1.9
Medication: Cholesterol lowering	0.7	1.0	5.4	-2.3	-1.0	-0.2	-0.5	-0.3	-0.8	-1.0	-0.9	-0.5	-1.0
Depression (self-reported)	0.1	0.2	0.6	-0.6	0.5	0.0	-0.2	-0.0	0.1	0.8	0.2	0.4	0.5
Medication: Lansoprazole	0.7	0.8	2.4	0.6	-1.5	0.0	-0.0	-0.0	-1.0	-0.6	-0.9	-0.9	-1.4
Prospective memory result	0.2	0.2	0.7	-0.8	-0.7	-0.4	0.0	0.1	0.2	0.1	0.2	-0.4	-0.5
Lung cancer (father)	0.8	0.9	5.2	-2.3	0.9	-0.6	0.3	0.3	0.1	1.2	0.0	0.6	1.0
Illnesses of mother	2.7	3.3	9.5	2.0	3.0	-1.1	1.3	1.4	0.3	2.3	0.5	-0.1	3.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.1	-0.6	-1.0	0.1	-0.4	-0.8	-0.3	-0.5	-0.3	0.1	-1.0
Pulse wave Arterial Stiffness index	0.5	0.6	2.6	1.6	-0.1	-0.4	-0.2	1.0	0.8	0.7	0.9	0.5	0.0
Impedance of arm (left)	1.4	6.6	13.4	-2.3	-0.9	3.5	-2.8	-3.0	-2.3	-2.5	-2.0	-3.7	-1.7
Arm fat mass (right)	0.1	0.3	0.9	0.8	-0.9	-0.7	0.3	0.4	-0.2	-0.2	-0.3	0.2	-0.7
Trunk predicted mass	0.2	1.1	3.2	1.1	-1.1	-1.8	1.2	0.6	0.9	0.1	0.8	1.3	-0.6
Standing height	0.1	1.4	3.1	0.2	-1.7	0.4	-0.6	-1.6	-0.5	-1.8	-0.4	-1.2	-1.7
Length of working week for main job	0.5	0.6	1.7	0.8	1.3	-0.0	0.2	0.1	-0.7	0.7	-0.6	-0.5	1.3
Exposure to tobacco smoke at home	0.6	0.7	3.3	-1.0	0.7	1.2	-1.8	-0.3	-0.1	0.7	0.1	-0.6	0.4
Breastfed as a baby	3.9	4.8	9.9	-3.1	-0.5	2.7	-2.9	-2.2	-1.9	-1.6	-1.6	-2.6	-1.0
Tense / ‘highly strung’	0.3	0.5	1.7	-0.2	1.3	0.6	-0.3	0.6	0.4	0.8	0.5	0.0	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	2.0	3.0	6.2	-2.2	0.5	1.7	-1.7	-1.5	-2.5	-1.0	-2.4	-2.0	0.1
Hair/balding pattern: Pattern 4	0.4	0.9	3.4	1.8	-1.4	-0.0	0.7	-0.1	0.4	-0.9	0.3	0.5	-1.2
Birth weight of first child	0.2	0.4	1.1	0.2	0.4	0.5	-0.3	-0.7	-1.1	-0.5	-1.1	-0.5	0.2
Peak expiratory flow (PEF)	0.5	1.1	1.9	-0.3	-1.3	0.4	-0.7	-1.4	-1.4	-1.2	-1.4	-0.7	-1.2
Pulse wave reflection index	0.4	0.5	1.0	0.9	-1.0	0.6	-0.9	-0.4	0.4	-0.0	0.4	0.5	-1.0
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.7	0.4	0.8	-1.5	0.5	1.1	0.5	1.6	0.7	1.2	1.2
Loud music exposure frequency	0.9	1.0	2.6	-1.6	-1.1	-0.4	-0.9	-0.6	-0.7	-0.9	-0.8	-1.4	-0.9
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	4.1	2.0	0.2	-0.1	-0.2	-0.4	-0.0	-0.8	-0.2	0.1	0.2
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	4.8	-2.2	0.6	0.1	-0.5	-0.1	-0.7	0.2	-0.6	-1.0	0.5
Blood clot in the leg (DVT)	0.9	1.2	2.8	-0.6	-0.5	1.1	-1.1	-1.5	-1.2	-0.9	-1.1	-1.7	-0.8
Medication: Paracetamol	0.7	1.1	3.5	-0.8	-1.9	-1.1	-0.5	0.1	0.7	0.3	0.6	1.4	-1.5
Headache pain in last month	0.8	1.4	2.2	0.8	0.7	-1.5	0.7	1.4	1.4	1.4	1.4	1.4	1.0
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	3.7	1.9	1.0	-0.5	1.3	0.3	0.4	1.2	0.5	0.5	1.1
Glaucoma (self-reported)	0.6	0.7	2.4	0.2	1.4	0.1	0.6	-0.2	-0.6	0.3	-0.3	-1.6	1.3
Gout (self-reported)	0.4	0.6	1.9	0.6	-0.8	-1.2	1.4	0.0	-0.4	0.2	-0.7	0.8	-0.4
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	2.1	-0.1	0.8	-0.8	1.4	0.6	0.4	0.8	0.6	0.4	1.0
Medication: Amlodipine	0.4	0.6	1.6	-0.6	-1.1	0.1	-0.3	-0.6	-0.6	-1.3	-0.6	-0.7	-1.1
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.3	0.4	0.3	0.5	0.3	0.0	0.5	0.1	0.3	-0.4	0.1
Birth weight	0.6	1.2	2.5	-0.4	-0.8	0.9	-1.2	-1.6	-1.5	-0.7	-1.2	-1.4	-0.9
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.7	0.8	-0.3	-0.1	0.5	0.1	-0.1	-0.4	-0.2	0.4	-0.3
High blood pressure (siblings)	0.2	0.3	0.8	-0.2	0.2	0.4	-0.1	-0.6	-0.8	-0.5	-0.7	-0.9	0.1
Forced vital capacity (FVC), Best measure	0.4	1.5	3.8	-1.0	-1.3	1.1	-1.1	-1.9	-1.0	-1.2	-1.1	-0.8	-1.5
Body fat percentage	0.1	0.2	0.5	0.7	-0.7	0.0	-0.3	0.2	-0.4	-0.3	-0.5	-0.1	-0.7
Leg fat percentage (right)	0.3	1.0	2.3	1.5	-0.6	-1.4	0.8	1.4	0.6	0.7	0.5	1.3	-0.3
Arm fat-free mass (right)	0.4	2.0	4.5	1.5	-0.6	-2.1	1.6	1.3	1.4	0.7	1.3	2.0	0.0
Exposure to tobacco smoke outside home	0.6	0.8	4.9	-2.2	0.9	0.8	-0.4	-0.2	-0.8	0.2	-0.6	-0.7	0.7
Comparative body size at age 10	0.7	1.8	7.3	1.5	-0.6	-0.7	0.7	1.1	1.8	0.5	1.6	2.7	-0.4
Number of full brothers	2.1	2.6	4.1	-1.3	-1.7	0.8	-0.8	-1.9	-1.9	-2.0	-1.8	-1.6	-1.7
Worry too long after embarrassment	0.3	0.6	1.4	0.5	-0.6	-0.3	-0.0	0.9	1.2	0.9	1.1	0.8	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.8	-0.9	0.0	0.6	-0.7	-0.5	-0.5	-0.2	-0.5	-0.4	-0.1
Wheeze or whistling in the chest in last year	0.1	0.1	0.5	-0.7	-0.3	0.0	-0.1	-0.0	-0.3	0.2	-0.3	0.1	-0.3
Number of children fathered	2.9	3.3	8.9	2.1	-0.4	-3.0	3.0	1.6	1.3	0.6	1.1	2.2	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	4.2	0.1	-2.0	-0.7	0.5	-0.3	0.1	-1.0	-0.3	0.5	-1.8
Age at first live birth	0.3	0.5	4.0	2.0	-0.4	0.2	0.8	-0.3	-0.0	-0.5	-0.3	-0.0	-0.5
Pulse wave peak to peak time	0.3	0.4	1.6	-1.3	0.2	0.1	0.4	-0.8	-0.6	-0.5	-0.7	-0.4	0.1
Health satisfaction	2.4	3.1	8.2	0.6	2.9	-1.1	0.9	2.4	0.8	2.2	1.1	-0.1	2.9
Shortness of breath walking on level ground	0.3	0.4	0.8	0.2	0.9	0.0	0.9	0.7	0.4	0.2	0.5	-0.6	0.8
Qualifications: College or University degree	0.3	1.1	3.0	1.3	-0.5	0.8	0.1	-1.1	-0.7	-1.7	-0.8	-1.6	-0.6
Eye problems/disorders: None of the above	0.3	0.4	1.0	0.3	-0.9	-0.7	-1.0	-0.2	-0.4	0.3	-0.7	0.4	-0.6
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.6	-0.9	0.8	-0.1	-0.2	-0.2	-1.0	1.0	-0.8	-1.3	0.8
Emphysema/chronic bronchitis	0.4	0.4	1.2	0.7	1.0	1.1	-0.3	0.0	0.3	0.6	0.7	0.1	0.7
Medication for pain relief, constipation, heartburn	0.7	1.2	3.6	1.4	1.4	1.9	-0.1	-0.7	-0.6	-0.7	-0.7	-1.1	0.8
Neck or shoulder pain in last month	0.1	0.2	0.6	0.2	-0.0	-0.0	-0.6	0.5	0.1	-0.7	0.2	0.8	-0.0
Medication: Blood pressure	0.3	0.6	1.4	-0.7	-1.2	0.4	-1.2	-0.4	-0.0	-1.0	0.0	0.3	-1.2
Angina (self-reported)	0.5	0.7	3.9	0.0	-0.1	-1.2	2.0	0.9	0.2	0.3	0.3	0.3	0.2
Migraine (self-reported)	0.8	1.0	3.3	0.1	-1.8	0.1	-0.5	-0.7	-0.5	-1.6	-0.7	-0.1	-1.7
Medication: Ibuprofen	1.3	1.6	4.3	0.1	1.5	-2.1	0.5	1.5	-0.1	1.6	0.1	0.7	2.0
Medication: Allopurinol	1.8	2.4	6.6	1.8	0.5	-2.1	2.6	1.4	0.8	1.3	0.7	2.1	0.9
Medication: Omeprazole	0.7	0.8	2.9	1.4	-0.6	1.0	-0.7	0.0	0.3	-1.7	0.3	-0.4	-0.9
Medication: Seretide 50 evohaler	1.4	1.6	2.8	-0.9	-1.4	1.4	-1.7	-1.5	-0.7	-1.1	-0.7	-1.0	-1.6
Mean time to correctly identify matches	0.2	0.4	0.7	-0.2	0.7	-0.4	0.8	0.7	0.6	0.8	0.5	-0.4	0.7
Heart disease (mother)	1.3	1.5	4.4	-0.8	-1.5	1.6	-2.1	-0.9	0.3	-1.2	0.2	0.3	-1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.6	1.0	-0.4	0.2	0.0	-0.3	-0.4	-1.3	-0.6	0.2	-0.5
Whole body fat mass	0.1	0.3	0.9	0.9	-0.8	-0.6	0.1	0.4	-0.2	-0.1	-0.3	0.2	-0.6
Leg fat mass (right)	0.2	0.8	1.7	1.3	-1.2	-1.2	0.6	0.7	0.4	0.2	0.2	1.2	-0.8
Arm predicted mass (right)	0.5	2.3	5.4	1.7	-0.4	-2.3	1.8	1.4	1.5	1.0	1.4	2.1	0.2
Pulse rate, automated reading	0.4	1.2	3.3	1.8	1.7	0.7	-0.3	1.0	0.8	0.9	0.8	-0.3	1.5
Alcohol intake frequency.	0.5	1.2	5.4	-2.3	0.0	1.5	-1.6	-1.1	-0.3	-0.6	0.0	0.3	-0.4
Comparative height size at age 10	0.1	0.3	0.8	0.6	-0.7	-0.1	0.9	-0.1	0.8	-0.5	0.7	-0.1	-0.7
Number of full sisters	0.8	1.0	2.4	-1.0	-0.7	-0.1	-0.6	-1.1	-1.5	-1.1	-1.5	-0.7	-0.6
Suffer from ‘nerves’	0.5	0.8	2.0	-1.0	-0.3	0.3	-1.0	-0.6	-1.3	-0.4	-1.2	-1.4	-0.4
Overall health rating	0.1	0.3	0.7	-0.4	0.4	-0.8	-0.1	0.9	-0.2	0.7	-0.1	-0.6	0.5
Chest pain or discomfort	0.9	1.2	2.7	-1.2	-0.9	-0.1	-0.3	-1.0	-1.6	-1.1	-1.5	-1.4	-0.8
Had major operations	1.3	1.5	3.1	0.3	-1.6	0.7	-1.2	-1.4	-1.1	-1.8	-1.0	-0.6	-1.6
Age at last live birth	0.2	0.2	0.9	0.5	-0.9	0.2	0.2	-0.6	0.0	-0.3	-0.1	0.0	-0.9
Family relationship satisfaction	0.7	0.9	2.3	-0.8	1.4	-0.3	0.0	0.8	-0.0	1.5	0.2	-1.0	1.5
Leg pain on walking	0.3	0.4	1.3	-0.6	1.2	-0.1	0.5	0.7	-0.0	0.7	0.1	0.3	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	5.8	-2.4	0.7	1.2	-0.1	0.1	0.4	0.2	0.3	-0.4	0.3
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.5	1.0	-0.3	-1.2	0.2	0.9	0.5	-0.2	0.3	1.0	0.1
Illness, injury, bereavement, stress in last 2 years	2.5	3.0	7.6	-0.9	-1.8	2.1	-1.6	-1.9	-0.9	-2.8	-0.9	-1.1	-2.2
Medication: Aspirin	0.9	1.2	7.7	-2.8	-0.2	0.3	-0.8	-0.7	-1.1	-0.1	-0.8	-1.1	-0.3
Supplements: Vitamin C	0.9	1.1	1.9	-1.3	0.7	1.3	-1.0	-1.2	-0.9	-1.1	-0.7	-1.4	0.3
Knee pain experienced in last month	0.9	1.4	3.7	-1.2	1.9	1.0	-0.3	-0.1	-1.4	0.5	-1.4	-1.0	1.5
Hypertension (Self-reported)	0.2	0.5	1.7	-1.3	-1.1	-0.3	-0.7	0.1	0.0	-0.6	-0.0	-0.2	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.6	3.0	0.9	-0.5	1.2	-0.9	-1.0	-1.7	-1.6	-1.7	-1.6	-0.8
Illnesses of father: Heart disease	0.5	0.7	2.5	-1.6	0.1	0.4	0.1	0.9	1.1	1.0	1.0	-0.3	0.0
Illnesses of siblings: Diabetes	1.8	2.2	3.1	-1.8	-1.7	0.8	-1.6	-1.8	-1.3	-0.9	-1.2	-1.7	-1.7
Smoking status: Previous	0.5	0.7	2.6	0.8	-1.3	-0.9	0.3	0.1	0.1	-0.2	-0.1	1.6	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.4	0.5	-1.0	-1.2	0.2	-0.0	-0.6	-0.9	-0.8	-0.5	-0.6
Whole body fat-free mass	0.1	0.8	2.2	1.0	-0.9	-1.5	1.0	0.5	0.8	0.2	0.7	1.1	-0.4
Leg fat-free mass (right)	0.0	0.2	0.5	0.3	-0.7	-0.6	0.3	-0.1	0.2	-0.1	0.1	0.5	-0.5
Arm fat percentage (left)	0.1	0.4	1.2	-0.1	-1.1	0.1	-0.5	-0.3	-0.8	-0.5	-0.8	-0.4	-1.1
Average weekly red wine intake	0.7	1.0	6.0	2.4	0.2	-1.2	1.3	0.9	0.4	0.2	0.0	-0.1	0.4
Handedness (chirality/laterality): Left-handed	0.6	0.8	2.4	0.1	0.5	-1.3	1.5	1.3	0.3	1.0	0.3	0.1	0.8
Mood swings	0.3	0.6	3.2	-1.8	-0.2	-0.2	-0.5	0.6	0.4	1.2	0.5	0.3	-0.0
Loneliness, isolation	1.0	1.4	4.2	-0.5	2.0	-0.3	0.1	1.1	-0.3	2.0	0.0	-0.4	2.0
Long-standing illness, disability or infirmity	0.9	1.4	2.6	0.1	1.5	-1.0	1.3	1.6	0.8	1.6	0.8	0.3	1.6
Ever had bowel cancer screening	0.6	0.7	3.1	0.4	0.1	1.8	-0.7	-0.5	-0.6	-1.5	-0.6	-0.1	-0.4
Diabetes diagnosed by doctor	1.6	2.6	5.2	-1.7	-1.6	1.9	-1.3	-1.9	-0.7	-1.4	-0.6	-2.3	-1.9
Ever had stillbirth, spontaneous miscarriage or termination	2.0	2.2	4.5	-0.1	0.3	-2.1	1.9	1.7	1.2	2.1	0.9	1.9	0.8
Friendships satisfaction	0.5	0.6	1.6	-1.2	1.3	1.2	-0.1	-0.3	-0.6	0.0	-0.5	-0.7	0.8
Qualifications: nursing, teaching	0.6	1.0	2.7	1.5	1.5	-0.8	0.7	0.5	-0.4	0.2	-0.5	-0.6	1.6
Commuting to job workplace: Walk	0.9	1.0	2.3	0.6	0.5	-0.5	0.9	1.0	1.4	1.5	1.5	0.8	0.6
Eye problems/disorders: Cataract	1.8	2.1	3.6	-0.7	1.6	-0.2	1.7	1.5	1.7	1.1	1.8	1.9	1.4
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.0	0.7	1.0	-0.7	0.4	1.0	1.1	0.7	1.4	0.2	1.1
Medication for cholesterol	0.4	0.6	1.9	1.4	1.3	0.7	-0.3	-0.3	0.2	-0.0	0.2	-0.8	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.0	-0.4	0.1	-0.3	-0.1	-0.6	-1.0	-0.2	-0.8	-0.8	0.2
Back pain experienced in last month	0.2	0.3	1.5	1.2	0.6	0.5	-0.7	0.3	-0.2	-0.4	-0.3	-0.1	0.4
Mineral and other dietary supplements	0.5	0.6	3.0	-0.1	-1.7	-0.2	-0.2	-0.5	-0.2	-0.7	-0.3	0.2	-1.5
Breast cancer (self-reported)	1.3	1.6	6.9	2.6	1.0	-0.2	1.2	0.5	1.3	1.0	1.3	1.1	0.9
Asthma (self-reported)	0.4	0.8	1.9	-0.9	0.2	1.1	-0.5	-1.2	-1.0	-0.7	-0.9	-1.4	-0.1
Osteoporosis (self-reported)	0.6	0.8	2.6	0.6	0.7	-0.0	-0.1	0.8	1.1	1.6	1.2	0.7	0.7
Osteoarthritis (self-reported)	0.6	0.7	1.6	-0.9	0.3	1.3	-0.9	-0.7	-1.3	-0.6	-1.1	-0.6	0.0
Medication: Aspirin	0.8	1.0	6.8	-2.6	-0.6	0.1	-0.8	-0.6	-0.8	-0.1	-0.5	-1.0	-0.6
Medication: Gliclazide	0.6	0.6	1.4	-0.9	-1.0	1.0	-0.7	-0.8	0.0	-0.5	-0.1	-0.8	-1.2
Illnesses of father: None of the above (group 1)	0.5	0.6	2.9	1.7	-0.5	0.4	-0.9	-0.7	-0.7	-0.5	-0.6	0.1	-0.4
Smoking status: Current	0.3	0.4	2.1	-1.2	0.1	-0.1	-0.3	-0.2	-0.4	1.4	-0.4	-0.5	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	2.5	-0.3	-1.1	1.3	-0.7	-1.3	-1.1	-1.6	-1.2	-0.4	-1.3
Whole body water mass	0.2	0.9	2.6	1.1	-0.8	-1.6	1.1	0.6	0.8	0.2	0.7	1.2	-0.4
Leg predicted mass (right)	0.0	0.2	0.5	0.4	-0.6	-0.7	0.3	-0.0	0.3	-0.1	0.2	0.5	-0.4
Arm fat mass (left)	0.1	0.4	1.3	0.8	-1.2	-0.9	0.5	0.3	-0.2	-0.3	-0.2	0.4	-0.9
Number of self-reported non-cancer illnesses	1.2	2.1	5.4	-1.1	-2.3	0.2	-0.7	-1.0	-1.2	-2.1	-1.3	-0.8	-2.2
Average weekly champagne plus white wine intake	0.4	0.6	3.6	1.9	-0.8	-0.1	-0.0	-0.2	-0.4	-0.7	-0.6	-0.3	-0.7
Miserableness	0.8	1.4	3.5	0.3	1.1	0.3	0.6	1.2	1.6	0.9	1.9	1.6	1.0
Guilty feelings	0.2	0.3	0.8	-0.7	-0.5	-0.4	0.7	0.9	0.4	0.3	0.4	0.5	-0.3
Wears glasses or contact lenses	0.4	0.4	1.3	-0.2	0.2	0.2	0.1	-0.5	-1.2	-0.6	-1.1	-1.1	0.2
Ever taken oral contraceptive pill	0.3	0.3	1.8	1.3	0.4	-0.4	0.2	0.4	-0.1	0.7	-0.3	0.1	0.5
Hearing aid user	0.3	0.4	1.7	-1.3	0.1	0.9	-0.7	-0.5	0.0	-0.5	-0.0	-0.0	-0.2
Mother’s age at death	0.6	0.8	3.1	1.3	0.6	0.3	-0.3	0.5	0.9	0.9	0.8	1.8	0.5
Financial situation satisfaction	0.1	0.1	1.0	-1.0	0.1	0.1	0.0	0.1	0.1	0.4	0.0	-0.4	0.1
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.9	0.5	-0.9	-0.9	0.8	0.5	0.1	-0.6	-0.3	0.6	-0.6
Commuting to job workplace: Public transport	0.2	0.2	0.5	0.2	0.6	0.3	0.2	-0.0	0.5	0.7	0.5	0.5	0.5
Eye problems/disorders: Glaucoma	0.6	0.7	3.1	0.5	1.1	0.1	0.2	-0.4	-1.0	-0.2	-0.8	-1.8	1.0
Medication: Blood pressure	1.3	2.4	7.4	-1.5	-2.7	0.8	-1.1	-1.3	-0.4	-1.7	-0.4	-0.8	-2.7
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.7	-0.7	-0.9	0.5	-1.2	-0.7	-1.3	-0.5	-1.3	-0.1	-0.9
Supplements: Fish oil (including cod liver oil)	1.2	1.5	6.7	-0.0	2.6	0.6	0.5	0.9	0.3	1.0	0.5	-0.6	2.3
High cholesterol (Self-reported)	1.9	3.4	18.3	-4.3	-2.8	-1.0	-0.6	0.4	0.5	-0.6	0.3	0.3	-2.4
Medication: Bendroflumethiazide	0.3	0.5	1.3	-0.7	-0.6	0.3	-1.1	-0.6	-0.8	-0.3	-0.7	-1.0	-0.7
Medication: Paracetamol	0.6	0.9	3.2	-1.2	-1.8	-0.5	-1.0	-0.4	0.3	-0.3	0.2	0.4	-1.6
Medication: Lisinopril	0.6	0.8	2.3	-1.5	-1.2	0.7	-1.3	-0.7	0.1	-0.3	0.1	-0.2	-1.3
Medication: Atorvastatin	2.4	2.9	6.8	-1.7	-2.6	-0.7	-1.1	-1.2	-1.9	-0.6	-2.4	-1.3	-2.2
Illnesses of father: High blood pressure	0.5	0.6	2.5	1.6	-0.4	-1.4	0.9	0.2	0.2	-0.2	0.4	0.6	-0.0
Alcohol drinker status: Never	1.0	1.2	4.0	2.0	0.4	-0.5	0.8	0.7	1.2	1.1	1.3	1.4	0.4
Ever smoked	0.2	0.3	1.0	-1.0	-0.2	0.3	-0.6	-0.6	-0.7	0.3	-0.7	-0.3	-0.3
Basal metabolic rate	0.1	0.8	2.2	1.0	-1.1	-1.5	0.9	0.5	0.7	0.0	0.6	1.0	-0.7
Leg fat percentage (left)	0.3	1.0	2.6	1.6	-0.6	-1.3	0.7	1.4	0.6	0.6	0.5	1.3	-0.2
Arm fat-free mass (left)	0.4	2.0	4.8	1.8	-0.6	-2.2	1.7	1.3	1.2	0.7	1.1	1.9	-0.0
Number of operations (self-reported)	0.4	0.5	3.1	1.7	-0.8	-0.3	0.5	-0.4	-0.0	-0.2	-0.0	1.0	-0.6
Average weekly beer plus cider intake	2.4	3.4	8.8	0.2	1.4	-1.9	1.9	2.4	1.6	3.0	1.4	1.7	1.8
Irritability	0.7	1.2	1.6	1.0	1.2	-0.3	1.2	1.1	1.2	1.1	1.2	1.3	1.2
Risk taking	0.3	0.4	1.6	-0.6	1.3	0.9	-0.1	-0.0	-0.3	0.5	-0.4	-0.0	1.0
Ever had prostate specific antigen (PSA) test	0.6	0.7	2.6	0.6	-1.6	-0.1	-0.5	-0.5	0.2	-1.1	0.0	-0.0	-1.5
Fractured/broken bones in last 5 years	0.5	0.6	2.1	0.1	1.4	0.8	-0.1	-0.1	-0.8	0.4	-0.7	-1.1	1.1
Age started oral contraceptive pill	1.4	1.7	2.4	-1.4	-1.0	1.5	-1.3	-1.5	-1.3	-0.7	-1.5	-1.4	-1.3
Diastolic blood pressure, automated reading	0.3	0.9	1.9	0.2	1.0	-0.6	-0.1	1.3	1.0	1.4	1.2	0.6	1.1
Ever depressed for a whole week	2.0	2.5	7.3	-1.1	0.2	0.8	-1.0	-1.4	-2.4	-1.3	-2.3	-2.7	0.0
Unable to work because of sickness or disability	0.5	0.6	1.9	0.1	1.1	0.5	0.3	-0.3	-1.4	-0.2	-1.1	-0.7	0.9
Commuting to job workplace: Cycle	0.3	0.3	0.7	-0.4	-0.4	0.7	-0.3	-0.4	-0.7	-0.8	-0.9	-0.1	-0.5
Myopia	0.5	0.7	2.4	1.2	-0.2	-1.6	1.2	0.5	0.1	0.8	-0.2	1.1	0.2
Vascular/heart problems diagnosed by doctor	0.4	1.0	3.2	1.8	1.8	0.7	0.5	0.0	-0.2	0.7	-0.2	0.2	1.5
Cholesterol lowering medication	3.1	4.6	23.8	-4.9	-3.0	0.4	-1.4	-0.9	-0.4	-0.9	-0.6	-0.9	-2.9
Medication: Omeprazole (e.g. Zanprol)	0.9	1.0	3.9	2.0	-0.7	-0.5	0.5	1.2	1.2	-0.5	1.1	0.8	-0.6
Pain experienced in last month	0.1	0.2	0.7	-0.7	-0.9	-0.1	-0.3	-0.3	0.2	0.4	0.1	0.0	-0.7
Supplements: Calcium	0.5	0.5	1.3	-0.9	1.1	0.7	-1.1	0.1	-0.4	0.5	-0.2	-0.8	0.8
Basal cell carcinoma (self-reported)	0.7	0.8	4.1	0.0	2.0	0.4	0.1	0.5	-0.1	0.7	0.1	-0.6	1.7
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.6	-0.4	-0.7	-1.2	1.2	0.2	0.1	0.2	0.1	0.7	-0.4
Deep venous thrombosis (DVT) (self-reported)	1.3	1.6	4.2	-0.6	-0.5	1.1	-1.2	-1.6	-1.5	-1.0	-1.4	-2.1	-0.8
Heart disease (siblings)	0.4	0.5	2.3	-1.5	-0.3	0.4	-0.7	-0.2	-0.6	-0.6	-0.5	-0.8	-0.4
Alcohol drinker status: Previous	0.9	1.0	2.8	-0.3	-0.3	0.6	-0.7	-1.0	-1.7	-1.0	-1.6	-1.2	-0.5
Pack years of smoking	0.5	0.7	2.3	-1.5	-0.5	0.1	0.1	-0.8	-1.3	-0.6	-1.1	-0.6	-0.5
Impedance of whole body	0.8	3.9	9.5	-1.4	-0.6	2.5	-2.2	-2.1	-1.9	-1.9	-1.7	-3.1	-1.2
Leg fat mass (left)	0.2	0.7	1.8	1.4	-1.1	-1.1	0.4	0.6	0.3	0.1	0.1	1.2	-0.8
Arm predicted mass (left)	0.4	2.0	4.9	1.8	-0.7	-2.2	1.6	1.3	1.2	0.7	1.1	1.9	-0.1