Hub : Traits :

Alzheimer’s Disease (in father)

14 significantly associated models · 11 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	11	85421392	86026808	1	1	2.1e-09	8.0e-08	4.6e-01	98	PICALM
2	19	44190626	46680895	10	11	2.7e-30	8.3e-193	2.4e-22	89	APOC1 APOC1P1 APOC2 APOE CEACAM19 ERCC1 PVRL2 TOMM40 ZNF285

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Alzheimer’s Disease (including proxy)	265.00	9	9	20.0	0.99	2.6e-10	APOC1 APOC1P1 APOC2 APOE CEACAM19 PICALM PVRL2 TOMM40 ZNF285
Alzheimer’s Disease (in mother)	109.41	9	8	17.8	0.99	4.6e-09	APOC1 APOC1P1 APOC2 APOE CEACAM19 PICALM PVRL2 TOMM40 ZNF285
LDL Cholesterol	36.39	7	5	11.1	0.10	8.3e-01	APOC1 APOE CEACAM19 ERCC1 PVRL2 TOMM40 ZNF285
Triglycerides	15.93	6	4	8.9	0.29	5.8e-01	APOC1 APOC2 APOE PVRL2 TOMM40 ZNF285
High cholesterol (Self-reported)	12.69	7	2	4.4	0.67	1.0e-01	APOC1P1 APOC2 APOE CEACAM19 ERCC1 PVRL2 ZNF285
Cholesterol lowering medication	7.59	5	1	2.2	0.96	8.5e-03	APOC1P1 CEACAM19 ERCC1 PVRL2 ZNF285
Average weekly fortified wine intake	7.25	2	1	2.2	-0.21	7.9e-01	APOC1P1 TOMM40
Medication: Simvastatin	6.43	5	1	2.2	0.50	3.9e-01	APOE CEACAM19 ERCC1 PVRL2 ZNF285
Medication: Cholesterol lowering	5.01	3	1	2.2	0.00	1.0e+00	CEACAM19 PVRL2 ZNF285
Illnesses of father: None of the above (group 1)	4.98	2	0	0.0	-0.11	8.9e-01	APOC1P1 TOMM40
Loud music exposure frequency	4.50	2	0	0.0	0.86	1.4e-01	APOC1P1 TOMM40
Medication: Atorvastatin	4.48	2	1	2.2	0.00	1.0e+00	PVRL2 ZNF285
Illnesses of mother	4.31	2	0	0.0	0.00	1.0e+00	APOC1P1 ZNF285
Cardiovascular Disease	3.47	5	1	2.2	0.43	4.7e-01	APOC1P1 APOE ERCC1 PVRL2 ZNF285
Diabetes (mother)	3.38	2	0	0.0	0.00	1.0e+00	APOC1 PVRL2
HDL Cholesterol	3.33	3	0	0.0	0.00	1.0e+00	APOC1 APOE PVRL2
Diabetes diagnosed by doctor	3.17	2	0	0.0	0.00	1.0e+00	APOC1 APOE
High blood pressure (mother)	2.78	2	0	0.0	0.00	1.0e+00	APOE TOMM40
Hand grip strength (right)	2.77	4	0	0.0	-0.51	3.1e-01	APOC1P1 PICALM PVRL2 TOMM40
Hand grip strength (left)	2.73	4	0	0.0	-0.56	2.5e-01	APOC1P1 PICALM PVRL2 TOMM40
Medication: Metformin	2.72	2	0	0.0	0.00	1.0e+00	APOC1 APOE
Blood White Count	2.70	6	4	8.9	-0.59	1.3e-01	APOC1 APOC1P1 APOE ERCC1 PVRL2 TOMM40
Supplements: Vitamin C	2.55	1	0	0.0	0.00	1.0e+00	PVRL2
Diabetes (self-reported)	2.52	2	0	0.0	0.00	1.0e+00	APOC1 APOE
Relative age of first facial hair	2.48	3	0	0.0	0.00	1.0e+00	APOC1P1 PICALM TOMM40
Illnesses of siblings: Diabetes	2.39	2	0	0.0	0.00	1.0e+00	APOC1 APOE
Blood Platelet Count	2.24	6	2	4.4	-0.30	5.6e-01	APOC1 APOE ERCC1 PICALM PVRL2 ZNF285
Mouth/teeth dental problems: Mouth ulcers	2.22	1	0	0.0	0.00	1.0e+00	TOMM40
Father's age at death	2.11	1	0	0.0	0.00	1.0e+00	ERCC1
Medication for cholesterol	2.08	1	0	0.0	0.00	1.0e+00	PVRL2
Pack years of smoking	2.03	1	0	0.0	0.00	1.0e+00	TOMM40
Medication: Ramipril	1.97	1	0	0.0	0.00	1.0e+00	APOE
Blood Eosinophil Count	1.94	4	3	6.7	-0.97	3.2e-02	APOC1 APOC2 APOE TOMM40
Heart disease (mother)	1.94	1	0	0.0	0.00	1.0e+00	APOC1
Nervous feelings	1.82	1	0	0.0	0.00	1.0e+00	TOMM40
Chronic bronchitis/emphysema (father)	1.77	1	0	0.0	0.00	1.0e+00	PICALM
Allergy or Eczema	1.73	1	0	0.0	0.00	1.0e+00	PVRL2
Birth weight	1.72	2	0	0.0	0.00	1.0e+00	APOC1P1 TOMM40
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.71	1	0	0.0	0.00	1.0e+00	CEACAM19
Shortness of breath walking on level ground	1.65	1	0	0.0	0.00	1.0e+00	ZNF285
Type 2 Diabetes (T2D) (2018)	1.62	1	0	0.0	0.00	1.0e+00	APOC1
Mouth/teeth dental problems	1.62	1	0	0.0	0.00	1.0e+00	PVRL2
Leg fat mass (left)	1.61	3	0	0.0	0.00	1.0e+00	APOC1P1 PVRL2 TOMM40
Hayfever, allergic rhinitis or eczema	1.60	1	0	0.0	0.00	1.0e+00	PVRL2
Primary Biliary Cirrhosis	1.55	1	0	0.0	0.00	1.0e+00	APOE
BMI	1.54	5	1	2.2	-0.98	2.3e-03	APOC1P1 CEACAM19 PVRL2 TOMM40 ZNF285
Weight	1.52	3	1	2.2	0.00	1.0e+00	APOC1P1 PVRL2 TOMM40
Knee pain experienced in last month	1.52	1	0	0.0	0.00	1.0e+00	PICALM
Leg fat mass (right)	1.51	3	0	0.0	0.00	1.0e+00	APOC1P1 PVRL2 TOMM40
Systolic Blood Pressure	1.45	4	0	0.0	0.08	9.2e-01	APOC1 APOC1P1 APOE PVRL2
Waist Hip Ratio (WHR)	1.44	3	0	0.0	0.00	1.0e+00	APOC1 APOE PICALM
Breastfed as a baby	1.40	1	0	0.0	0.00	1.0e+00	ERCC1
Waist circumference	1.38	3	0	0.0	0.00	1.0e+00	APOC1P1 PVRL2 TOMM40
Whole body fat mass	1.38	3	0	0.0	0.00	1.0e+00	APOC1P1 PVRL2 TOMM40
Chronotype (morning person)	1.37	1	0	0.0	0.00	1.0e+00	ZNF285
Leg fat percentage (left)	1.36	3	0	0.0	0.00	1.0e+00	APOC1P1 PVRL2 TOMM40
Arm fat mass (right)	1.34	3	0	0.0	0.00	1.0e+00	APOC1P1 PVRL2 TOMM40
Medication for cholesterol, blood pressure or diabetes	1.34	1	0	0.0	0.00	1.0e+00	PVRL2
Forced expiratory volume in 1-second (FEV1), predicted	1.34	3	0	0.0	0.00	1.0e+00	APOC1 APOE CEACAM19
Arm fat-free mass (left)	1.30	3	1	2.2	0.00	1.0e+00	APOC1P1 APOC2 TOMM40
Trunk fat mass	1.29	2	0	0.0	0.00	1.0e+00	APOC1P1 PVRL2
Arm predicted mass (left)	1.29	3	1	2.2	0.00	1.0e+00	APOC1P1 APOC2 TOMM40
Arm fat mass (left)	1.27	2	0	0.0	0.00	1.0e+00	APOC1P1 PVRL2
Bipolar Disorder or Schizophrenia	1.26	1	0	0.0	0.00	1.0e+00	APOC2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.26	1	0	0.0	0.00	1.0e+00	PVRL2
Basal metabolic rate	1.24	2	1	2.2	0.00	1.0e+00	APOC1P1 APOC2
Forced expiratory volume in 1-second (FEV1)	1.22	2	0	0.0	0.00	1.0e+00	PVRL2 TOMM40
Leg fat percentage (right)	1.22	3	0	0.0	0.00	1.0e+00	APOC1P1 PVRL2 TOMM40
Trunk fat-free mass	1.21	2	1	2.2	0.00	1.0e+00	APOC1P1 APOC2
Trunk predicted mass	1.17	2	1	2.2	0.00	1.0e+00	APOC1P1 APOC2
Body mass index (BMI)	1.16	2	0	0.0	0.00	1.0e+00	APOC1P1 PVRL2
Worrier / anxious feelings	1.14	1	0	0.0	0.00	1.0e+00	APOC1P1
Whole body fat-free mass	1.13	2	1	2.2	0.00	1.0e+00	APOC1P1 APOC2
Hip circumference	1.12	3	0	0.0	0.00	1.0e+00	APOC1P1 APOE PVRL2
Arm fat-free mass (right)	1.10	2	0	0.0	0.00	1.0e+00	APOC1P1 APOC2
Whole body water mass	1.10	2	1	2.2	0.00	1.0e+00	APOC1P1 APOC2
Forced vital capacity (FVC), Best measure	1.09	1	0	0.0	0.00	1.0e+00	PVRL2
Vascular/heart problems diagnosed by doctor	1.09	2	0	0.0	0.00	1.0e+00	APOC1 APOE
Body fat percentage	1.08	2	0	0.0	0.00	1.0e+00	APOC1P1 PVRL2
Height	1.06	7	4	8.9	-0.06	8.9e-01	APOC1 APOC1P1 APOC2 APOE CEACAM19 PICALM TOMM40
Lung FVC	1.03	2	0	0.0	0.00	1.0e+00	PVRL2 TOMM40
Forced vital capacity (FVC)	1.03	1	0	0.0	0.00	1.0e+00	PVRL2
Trunk fat percentage	1.02	2	0	0.0	0.00	1.0e+00	APOC1P1 PVRL2
Arm fat percentage (right)	1.02	2	0	0.0	0.00	1.0e+00	APOC1P1 PVRL2
Leg fat-free mass (left)	0.99	2	0	0.0	0.00	1.0e+00	APOC1P1 APOC2
Leg predicted mass (left)	0.99	2	0	0.0	0.00	1.0e+00	APOC1P1 APOC2
Arm fat percentage (left)	0.99	2	0	0.0	0.00	1.0e+00	APOC1P1 PVRL2
High blood pressure	0.98	2	0	0.0	0.00	1.0e+00	APOC1 APOE
Forced expiratory volume in 1-second (FEV1), Best measure	0.97	1	0	0.0	0.00	1.0e+00	PVRL2
Leg fat-free mass (right)	0.97	2	0	0.0	0.00	1.0e+00	APOC1P1 APOC2
Leg predicted mass (right)	0.97	2	0	0.0	0.00	1.0e+00	APOC1P1 APOC2
Arm predicted mass (right)	0.96	1	0	0.0	0.00	1.0e+00	APOC1P1
Comparative height size at age 10	0.94	1	0	0.0	0.00	1.0e+00	APOC1P1
Alcohol intake versus 10 years previously	0.92	1	0	0.0	0.00	1.0e+00	ERCC1
Vitamin and mineral supplements	0.91	1	0	0.0	0.00	1.0e+00	PVRL2
Hypertension (Self-reported)	0.90	2	0	0.0	0.00	1.0e+00	APOC1 APOE
Standing height	0.81	6	0	0.0	0.02	9.7e-01	APOC1 APOC1P1 APOC2 APOE CEACAM19 PICALM
Sitting height	0.67	3	0	0.0	0.00	1.0e+00	APOC1 APOE PICALM
Blood Red Count	0.58	3	0	0.0	0.00	1.0e+00	APOE PICALM PVRL2
Impedance of whole body	0.45	1	0	0.0	0.00	1.0e+00	APOC1P1
Heel T-Score	0.25	1	0	0.0	0.00	1.0e+00	ZNF285
Hair Pigment	0.21	1	0	0.0	0.00	1.0e+00	TOMM40

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.18
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	2	0.080	1.18
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	1	0.195	1.18
GTEx	Vagina	0	0.000	1.17
GTEx	Brain Hypothalamus	0	0.000	1.15
GTEx	Brain Putamen basal ganglia	0	0.000	1.15
GTEx	Liver	0	0.000	1.15
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	2	0.049	1.15
GTEx	Skin Not Sun Exposed Suprapubic	1	0.041	1.14
GTEx	Adrenal Gland	0	0.000	1.13
GTEx	Colon Transverse	0	0.000	1.13
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.13
GTEx	Adipose Visceral Omentum	1	0.049	1.12
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.12
GTEx	Thyroid	1	0.025	1.12
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.12
GTEx	Esophagus Mucosa	0	0.000	1.11
GTEx	Esophagus Muscularis	0	0.000	1.11
GTEx	Pancreas	0	0.000	1.11
GTEx	Pituitary	0	0.000	1.11
The Cancer Genome Atlas	Prostate Adenocarcinoma	1	0.022	1.11
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.11
GTEx	Brain Frontal Cortex BA9	0	0.000	1.10
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.10
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.10
GTEx	Colon Sigmoid	0	0.000	1.10
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.10
GTEx	Spleen	0	0.000	1.10
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.10
The Cancer Genome Atlas	Testicular Germ Cell Tumors	1	0.078	1.10
GTEx	Adipose Subcutaneous	0	0.000	1.09
GTEx	Artery Coronary	0	0.000	1.09
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.09
GTEx	Muscle Skeletal	0	0.000	1.09
GTEx	Nerve Tibial	1	0.023	1.09
GTEx	Testis	0	0.000	1.09
GTEx	Whole Blood	0	0.000	1.09
NTR	Blood	0	0.000	1.09
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.09
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.09
The Cancer Genome Atlas	Thyroid Carcinoma	2	0.039	1.09
GTEx	Breast Mammary Tissue	0	0.000	1.08
GTEx	Heart Left Ventricle	0	0.000	1.08
GTEx	Lung	0	0.000	1.08
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.08
YFS	Blood	0	0.000	1.08
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.08
The Cancer Genome Atlas	Brain Lower Grade Glioma	1	0.023	1.08
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.08
GTEx	Artery Tibial	0	0.000	1.07
GTEx	Brain Hippocampus	0	0.000	1.07
GTEx	Heart Atrial Appendage	0	0.000	1.07
GTEx	Stomach	0	0.000	1.07
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.07
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.07
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.07
GTEx	Artery Aorta	0	0.000	1.06
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.06
GTEx	Cells Transformed fibroblasts	0	0.000	1.06
GTEx	Small Intestine Terminal Ileum	0	0.000	1.06
METSIM	Adipose	0	0.000	1.06
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.06
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.06
GTEx	Brain Cerebellum	0	0.000	1.05
GTEx	Prostate	0	0.000	1.05
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.05
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.05
GTEx	Brain Cortex	0	0.000	1.04
GTEx	Uterus	0	0.000	1.04
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.03
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.00
GTEx	Ovary	0	0.000	0.99
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	0.99
GTEx	Brain Caudate basal ganglia	0	0.000	0.98