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chr5:34,920,257-36,938,041

Best TWAS P=2.15e-54 · Best GWAS P=2.56e-59 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	NADKD1	0.08	0.06	bslmm	563	0.05	1.3e-06	-0.16	-5.6	1.8e-08	0.30	0.97	0.00	TRUE
2	GTEx	Adrenal Gland	LMBRD2	0.19	0.01	lasso	6	0.02	6.9e-02	-4.97	5.8	5.4e-09	-0.32	0.07	0.50	TRUE
3	GTEx	Brain Frontal Cortex BA9	SPEF2	0.39	0.23	enet	27	0.22	1.8e-06	-5.75	-6.8	1.2e-11	0.49	0.81	0.02	FALSE
4	GTEx	Brain Nucleus accumbens basal ganglia	SPEF2	0.31	0.24	lasso	6	0.19	9.2e-06	-5.77	-5.7	1.2e-08	0.40	0.40	0.17	FALSE
5	GTEx	Cells Transformed fibroblasts	SPEF2	0.26	0.01	enet	56	0.04	2.6e-04	-3.06	-7.6	4.0e-14	0.34	0.13	0.68	FALSE
6	GTEx	Lung	LMBRD2	0.13	0.03	enet	27	0.06	3.1e-05	-4.41	5.9	3.8e-09	-0.39	0.78	0.12	TRUE
7	GTEx	Testis	IL7R	0.25	0.19	lasso	6	0.18	2.1e-08	7.21	7.3	2.3e-13	-0.33	0.99	0.00	TRUE
8	METSIM	Adipose	SPEF2	0.06	0.01	blup	522	0.03	4.0e-05	3.99	-6.8	1.0e-11	0.36	0.74	0.02	TRUE
9	ROSMAP	Brain Pre-frontal Cortex	CAPSL	0.05	0.02	lasso	6	0.03	2.9e-04	7.86	-8.5	2.6e-17	0.55	0.29	0.42	TRUE
10	YFS	Blood	IL7R	0.03	0.01	bslmm	467	0.01	8.1e-05	3.65	6.3	3.4e-10	-0.39	0.82	0.05	TRUE
11	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	UGT3A2	0.04	0.00	blup	52	0.01	4.9e-02	-4.97	8.1	6.1e-16	-0.35	0.02	0.23	TRUE
12	The Cancer Genome Atlas	Breast Invasive Carcinoma	UGT3A2	0.06	0.02	blup	52	0.05	9.7e-10	4.04	6.4	2.0e-10	-0.30	0.97	0.02	FALSE
13	The Cancer Genome Atlas	Colon Adenocarcinoma	UGT3A2	0.11	0.08	lasso	5	0.04	2.9e-03	-4.97	5.4	5.3e-08	-0.31	0.33	0.27	FALSE
14	The Cancer Genome Atlas	Glioblastoma Multiforme	SPEF2	0.16	0.00	blup	136	0.08	1.9e-03	-5.20	-5.7	1.5e-08	0.47	0.09	0.36	FALSE
15	The Cancer Genome Atlas	Brain Lower Grade Glioma	SPEF2	0.03	0.04	lasso	5	0.02	8.4e-04	-5.77	-5.8	8.1e-09	0.40	0.38	0.08	FALSE
16	The Cancer Genome Atlas	Lung Adenocarcinoma	UGT3A2	0.11	0.09	lasso	2	0.11	6.0e-13	-4.83	5.2	2.0e-07	-0.33	1.00	0.00	FALSE
17	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IL7R	0.04	0.03	lasso	3	0.02	9.8e-04	-16.24	-15.5	2.1e-54	0.96	0.00	0.99	TRUE
18	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	UGT3A2	0.05	0.03	blup	52	0.04	2.8e-05	-4.59	5.4	5.7e-08	-0.22	0.06	0.60	TRUE
19	The Cancer Genome Atlas	Rectum Adenocarcinoma	UGT3A2	0.29	0.26	lasso	4	0.26	1.0e-06	-4.59	5.5	4.5e-08	-0.32	0.03	0.91	FALSE
20	The Cancer Genome Atlas	Thyroid Carcinoma	UGT3A2	0.05	0.00	blup	52	0.02	3.4e-03	3.91	6.5	8.0e-11	-0.34	0.02	0.13	TRUE