[Hub]/) : Traits : Allergy or Eczema : ← →

chr12:120,468,697-124,591,385

Best TWAS P=1.2e-17 · Best GWAS P=1.2e-17 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	SPPL3	0.19	0.16	lasso	12	0.21	4.8e-25	-7.5	7.2	4.6e-13	0.84	0.69	0.31	FALSE
2	GTEx	Adipose Subcutaneous	SPPL3	0.19	0.19	lasso	8	0.19	3.7e-15	8.1	8.0	9.7e-16	0.91	0.04	0.96	FALSE
3	GTEx	Adipose Visceral Omentum	SPPL3	0.17	0.11	enet	22	0.08	6.1e-05	-7.7	6.8	1.2e-11	0.78	0.19	0.73	FALSE
4	GTEx	Artery Aorta	CDK2AP1	0.17	0.19	lasso	2	0.15	8.0e-09	-5.4	5.4	5.8e-08	0.03	0.03	0.97	FALSE
5	GTEx	Artery Aorta	SPPL3	0.18	0.15	enet	13	0.17	1.4e-09	8.6	7.5	7.7e-14	0.91	0.00	1.00	FALSE
6	GTEx	Artery Aorta	RP11-282O18.3	0.18	0.19	lasso	9	0.16	4.3e-09	-5.4	5.5	3.9e-08	0.05	0.04	0.96	FALSE
7	GTEx	Artery Tibial	MPHOSPH9	0.05	0.03	lasso	3	0.03	2.2e-03	-4.5	-5.2	1.6e-07	-0.05	0.04	0.94	FALSE
8	GTEx	Artery Tibial	SPPL3	0.08	0.05	enet	16	0.05	1.2e-04	8.1	7.6	3.2e-14	0.85	0.02	0.97	FALSE
9	GTEx	Brain Cerebellum	SPPL3	0.29	0.22	enet	9	0.24	8.6e-08	8.1	8.3	6.9e-17	0.94	0.02	0.98	FALSE
10	GTEx	Brain Hypothalamus	OGFOD2	0.24	0.14	lasso	4	0.14	4.0e-04	-5.4	-5.2	1.5e-07	-0.09	0.05	0.90	FALSE
11	GTEx	Brain Putamen basal ganglia	SPPL3	0.23	-0.01	enet	20	0.00	2.7e-01	-7.7	6.3	2.6e-10	0.71	0.04	0.56	FALSE
12	GTEx	Breast Mammary Tissue	CDK2AP1	0.08	0.06	lasso	3	0.07	1.2e-04	-4.5	5.2	1.9e-07	0.04	0.06	0.90	FALSE
13	GTEx	Breast Mammary Tissue	SPPL3	0.12	0.01	enet	10	0.01	6.8e-02	-1.1	6.3	2.9e-10	0.61	0.02	0.85	FALSE
14	GTEx	Breast Mammary Tissue	RP11-282O18.3	0.10	0.06	lasso	6	0.08	5.4e-05	-4.5	5.2	1.9e-07	0.04	0.08	0.91	FALSE
15	GTEx	Breast Mammary Tissue (Female)	CAMKK2	0.08	0.00	lasso	4	0.02	6.8e-02	-7.8	7.7	2.1e-14	0.87	0.03	0.46	FALSE
16	GTEx	Breast Mammary Tissue (Female)	SPPL3	0.24	0.14	enet	7	0.03	5.1e-02	8.6	8.3	8.3e-17	0.97	0.01	0.97	FALSE
17	GTEx	Cells Transformed fibroblasts	OGFOD2	0.10	0.07	lasso	7	0.07	3.1e-06	-4.5	-5.2	1.7e-07	-0.06	0.33	0.67	FALSE
18	GTEx	Cells Transformed fibroblasts	CDK2AP1	0.31	0.32	lasso	8	0.35	8.5e-27	-5.4	5.5	2.8e-08	0.03	0.07	0.93	FALSE
19	GTEx	Cells Transformed fibroblasts	ABCB9	0.08	0.12	enet	7	0.12	4.3e-09	-4.5	-5.2	2.6e-07	-0.06	0.02	0.98	FALSE
20	GTEx	Cells Transformed fibroblasts	SPPL3	0.13	0.14	lasso	5	0.14	1.2e-10	6.3	7.2	8.8e-13	0.84	0.35	0.65	FALSE
21	GTEx	Cells Transformed fibroblasts	RP11-282O18.3	0.25	0.29	enet	16	0.28	2.2e-21	-5.4	5.6	1.8e-08	0.04	0.08	0.92	FALSE
22	GTEx	Colon Sigmoid	ABCB9	0.18	0.16	lasso	6	0.15	4.8e-06	-6.0	-5.5	3.7e-08	-0.05	0.03	0.97	FALSE
23	GTEx	Colon Sigmoid	SPPL3	0.13	0.03	lasso	3	0.01	1.2e-01	5.1	6.7	2.3e-11	0.71	0.11	0.44	FALSE
24	GTEx	Colon Transverse	CDK2AP1	0.17	0.19	enet	7	0.22	1.4e-10	-5.5	5.5	3.8e-08	0.05	0.04	0.96	FALSE
25	GTEx	Colon Transverse	RP11-282O18.3	0.18	0.19	enet	8	0.19	1.8e-09	-5.5	5.5	3.2e-08	0.05	0.05	0.95	FALSE
26	GTEx	Esophagus Gastroesophageal Junction	CDK2AP1	0.14	0.06	lasso	8	0.06	4.7e-03	-5.3	5.3	1.5e-07	0.04	0.04	0.64	FALSE
27	GTEx	Esophagus Gastroesophageal Junction	SPPL3	0.25	0.19	lasso	3	0.23	5.6e-09	8.1	7.3	2.1e-13	0.86	0.07	0.93	FALSE
28	GTEx	Esophagus Gastroesophageal Junction	RP11-282O18.3	0.16	0.06	lasso	9	0.07	2.3e-03	-5.3	5.5	4.9e-08	0.04	0.04	0.77	FALSE
29	GTEx	Esophagus Mucosa	CDK2AP1	0.30	0.36	lasso	5	0.38	1.9e-26	-5.4	5.5	3.3e-08	0.05	0.07	0.92	FALSE
30	GTEx	Esophagus Mucosa	ABCB9	0.10	0.03	lasso	5	0.05	5.4e-04	-5.3	-5.5	4.8e-08	-0.05	0.04	0.95	FALSE
31	GTEx	Esophagus Mucosa	RP11-282O18.3	0.29	0.34	lasso	4	0.34	1.9e-23	-5.3	5.5	4.6e-08	0.05	0.08	0.92	FALSE
32	GTEx	Esophagus Muscularis	MPHOSPH9	0.18	0.18	enet	17	0.18	4.8e-11	-5.9	-6.3	2.8e-10	-0.05	0.01	0.99	TRUE
33	GTEx	Esophagus Muscularis	C12orf65	0.06	0.04	lasso	4	0.04	2.0e-03	-5.7	5.2	1.8e-07	0.04	0.06	0.92	FALSE
34	GTEx	Esophagus Muscularis	ABCB9	0.10	0.08	lasso	6	0.05	3.8e-04	-5.3	-5.6	2.6e-08	-0.05	0.03	0.96	FALSE
35	GTEx	Esophagus Muscularis	SPPL3	0.16	0.14	lasso	2	0.16	3.8e-10	8.1	8.2	2.5e-16	0.93	0.04	0.96	FALSE
36	GTEx	Esophagus Muscularis	RP11-282O18.3	0.19	0.11	lasso	6	0.10	2.1e-06	-5.4	5.2	1.7e-07	0.05	0.05	0.95	FALSE
37	GTEx	Lung	ABCB9	0.04	0.02	lasso	3	0.02	8.0e-03	-5.7	-5.6	1.9e-08	-0.06	0.03	0.93	FALSE
38	GTEx	Lung	SPPL3	0.15	0.05	enet	27	0.06	1.1e-05	4.1	6.4	1.5e-10	0.74	0.15	0.85	FALSE
39	GTEx	Muscle Skeletal	ACADS	0.09	0.02	lasso	5	0.02	2.4e-03	-4.1	5.8	6.8e-09	0.69	0.04	0.92	FALSE
40	GTEx	Nerve Tibial	MPHOSPH9	0.07	0.04	lasso	4	0.01	7.0e-02	-6.0	-5.9	4.7e-09	-0.06	0.01	0.97	FALSE
41	GTEx	Nerve Tibial	CDK2AP1	0.11	0.11	enet	25	0.09	4.4e-07	-4.5	5.2	1.6e-07	0.03	0.07	0.93	FALSE
42	GTEx	Nerve Tibial	ABCB9	0.06	0.04	lasso	3	0.05	3.5e-04	-4.4	-5.5	4.6e-08	-0.04	0.02	0.97	FALSE
43	GTEx	Nerve Tibial	SPPL3	0.24	0.16	enet	33	0.21	4.8e-15	8.1	7.7	1.9e-14	0.88	0.01	0.99	FALSE
44	GTEx	Pancreas	CDK2AP1	0.24	0.27	lasso	3	0.26	3.1e-11	-5.5	5.5	2.9e-08	0.05	0.05	0.95	FALSE
45	GTEx	Pancreas	SPPL3	0.14	0.10	lasso	3	0.09	9.3e-05	8.6	8.4	4.2e-17	0.97	0.01	0.97	FALSE
46	GTEx	Pancreas	SETD8	0.20	0.12	lasso	5	0.13	3.4e-06	-5.6	5.2	2.2e-07	0.03	0.05	0.95	FALSE
47	GTEx	Pancreas	RP11-282O18.3	0.22	0.24	lasso	5	0.24	2.3e-10	-5.4	5.6	2.4e-08	0.04	0.05	0.95	FALSE
48	GTEx	Pituitary	SPPL3	0.24	0.11	enet	10	0.06	1.1e-02	7.1	6.5	6.9e-11	0.83	0.06	0.75	FALSE
49	GTEx	Skin Not Sun Exposed Suprapubic	CDK2AP1	0.17	0.12	lasso	10	0.12	3.4e-07	-6.0	5.9	4.7e-09	0.05	0.02	0.98	FALSE
50	GTEx	Skin Not Sun Exposed Suprapubic	RP11-282O18.3	0.13	0.10	lasso	6	0.09	1.9e-05	-5.7	5.9	3.1e-09	0.05	0.02	0.98	FALSE
51	GTEx	Skin Sun Exposed Lower leg	MPHOSPH9	0.06	0.05	enet	9	0.06	2.1e-05	-5.5	-5.6	2.6e-08	-0.05	0.04	0.94	FALSE
52	GTEx	Skin Sun Exposed Lower leg	CDK2AP1	0.21	0.22	lasso	5	0.22	3.4e-18	-5.4	5.4	6.6e-08	0.03	0.07	0.93	FALSE
53	GTEx	Skin Sun Exposed Lower leg	RP11-282O18.3	0.17	0.20	lasso	6	0.20	2.2e-16	-5.4	5.5	2.9e-08	0.04	0.07	0.93	FALSE
54	GTEx	Small Intestine Terminal Ileum	ABCB9	0.23	0.21	enet	12	0.22	1.0e-05	-5.7	-5.9	4.3e-09	-0.06	0.02	0.91	FALSE
55	GTEx	Stomach	MPHOSPH9	0.17	0.08	lasso	5	0.10	1.2e-05	-5.3	-5.2	1.5e-07	-0.05	0.05	0.94	FALSE
56	GTEx	Testis	MPHOSPH9	0.28	0.27	enet	23	0.32	1.3e-14	-5.7	-5.4	7.8e-08	-0.05	0.06	0.94	FALSE
57	GTEx	Testis	SPPL3	0.31	0.30	lasso	3	0.27	2.0e-12	8.1	8.3	1.2e-16	0.95	0.01	0.99	FALSE
58	GTEx	Thyroid	PITPNM2	0.04	0.07	lasso	2	0.06	1.6e-05	-5.4	-5.4	5.9e-08	-0.07	0.05	0.94	FALSE
59	GTEx	Thyroid	CDK2AP1	0.08	0.09	enet	7	0.10	8.2e-08	-5.4	5.6	2.6e-08	0.05	0.05	0.95	FALSE
60	GTEx	Thyroid	ACADS	0.29	0.29	lasso	4	0.33	8.1e-26	-7.6	-7.1	1.1e-12	-0.82	0.46	0.54	FALSE
61	GTEx	Thyroid	RP11-282O18.3	0.06	0.06	enet	6	0.06	3.6e-05	-5.4	5.6	1.8e-08	0.05	0.05	0.94	FALSE
62	METSIM	Adipose	CDK2AP1	0.11	0.14	enet	23	0.14	1.7e-20	-5.4	5.3	1.1e-07	0.04	0.08	0.92	FALSE
63	METSIM	Adipose	SPPL3	0.12	0.15	lasso	8	0.16	1.6e-22	8.6	8.0	9.4e-16	0.97	0.00	1.00	FALSE
64	YFS	Blood	MPHOSPH9	0.05	0.07	enet	31	0.07	3.7e-23	-5.5	-5.4	5.8e-08	-0.08	0.10	0.90	FALSE
65	YFS	Blood	SBNO1	0.03	0.03	lasso	6	0.03	1.2e-09	-5.3	5.5	2.9e-08	0.05	0.08	0.92	FALSE
66	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ABCB9	0.05	0.04	enet	5	0.04	2.4e-04	-5.7	-5.7	1.5e-08	-0.09	0.00	0.98	FALSE
67	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CDK2AP1	0.09	0.08	lasso	2	0.06	5.9e-06	-5.3	5.3	9.0e-08	0.04	0.01	0.99	FALSE
68	The Cancer Genome Atlas	Breast Invasive Carcinoma	CDK2AP1	0.07	0.08	lasso	7	0.08	5.0e-16	-5.3	5.5	4.3e-08	0.05	0.01	0.99	FALSE
69	The Cancer Genome Atlas	Breast Invasive Carcinoma	RILPL2	0.02	0.01	enet	8	0.01	2.6e-02	-5.5	-5.4	7.8e-08	-0.03	0.00	0.98	FALSE
70	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CDK2AP1	0.07	0.07	blup	34	0.05	1.1e-03	-5.4	5.5	4.7e-08	0.02	0.01	0.91	FALSE
71	The Cancer Genome Atlas	Colon Adenocarcinoma	CDK2AP1	0.12	0.17	lasso	4	0.17	6.3e-10	-5.3	5.3	9.7e-08	0.04	0.01	0.99	FALSE
72	The Cancer Genome Atlas	Colon Adenocarcinoma	MLXIP	0.06	0.04	lasso	7	0.02	2.7e-02	5.2	5.3	1.2e-07	-0.07	0.26	0.12	FALSE
73	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CDK2AP1	0.14	0.15	lasso	2	0.14	7.8e-16	-5.3	5.3	1.4e-07	0.04	0.01	0.99	FALSE
74	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CDK2AP1	0.11	0.13	lasso	5	0.14	5.9e-16	-5.4	5.5	3.6e-08	0.04	0.01	0.99	FALSE
75	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SPPL3	0.04	0.02	enet	5	0.02	5.9e-03	-6.5	6.8	9.4e-12	0.80	0.13	0.72	FALSE
76	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CDK2AP1	0.12	0.10	lasso	2	0.11	6.3e-07	-5.3	5.2	1.8e-07	0.04	0.01	0.99	FALSE
77	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PITPNM2	0.06	0.07	lasso	5	0.09	1.2e-05	-5.4	5.3	1.2e-07	0.05	0.04	0.96	FALSE
78	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SPPL3	0.11	0.01	lasso	1	0.01	1.0e-01	8.6	8.6	1.2e-17	1.00	0.00	0.89	TRUE
79	The Cancer Genome Atlas	Brain Lower Grade Glioma	SPPL3	0.07	0.09	lasso	3	0.09	9.9e-11	8.1	8.3	1.2e-16	0.94	0.03	0.97	FALSE
80	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	CDK2AP1	0.11	0.11	enet	5	0.11	1.2e-05	-5.4	5.4	5.6e-08	0.04	0.01	0.99	FALSE
81	The Cancer Genome Atlas	Lung Adenocarcinoma	CDK2AP1	0.03	0.04	lasso	1	0.04	1.2e-05	-5.3	5.3	9.0e-08	0.04	0.01	0.99	FALSE
82	The Cancer Genome Atlas	Lung Adenocarcinoma	SPPL3	0.06	0.02	enet	17	0.03	2.8e-04	8.6	6.5	6.7e-11	0.81	0.00	0.99	FALSE
83	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C12orf43	0.06	0.03	lasso	4	0.02	6.9e-03	6.0	5.3	1.3e-07	0.38	0.00	0.99	FALSE
84	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CDK2AP1	0.04	0.04	lasso	3	0.03	3.8e-04	-5.4	5.4	5.7e-08	0.03	0.01	0.97	FALSE
85	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	CDK2AP1	0.07	0.06	enet	7	0.06	7.0e-05	-5.4	5.3	8.8e-08	0.03	0.01	0.95	FALSE
86	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SPPL3	0.18	0.10	enet	11	0.15	9.1e-07	7.1	5.9	4.5e-09	0.66	0.37	0.56	FALSE
87	The Cancer Genome Atlas	Prostate Adenocarcinoma	CDK2AP1	0.06	0.07	lasso	2	0.06	1.7e-06	-5.4	5.5	3.2e-08	0.03	0.01	0.99	FALSE
88	The Cancer Genome Atlas	Prostate Adenocarcinoma	SPPL3	0.04	0.04	blup	95	0.04	3.7e-05	8.6	8.1	6.8e-16	0.94	0.01	0.99	FALSE
89	The Cancer Genome Atlas	Stomach Adenocarcinoma	CDK2AP1	0.09	0.10	lasso	2	0.10	1.8e-07	-5.4	5.2	1.7e-07	0.03	0.01	0.99	FALSE
90	The Cancer Genome Atlas	Stomach Adenocarcinoma	MLXIP	0.06	0.02	blup	68	0.04	1.2e-03	5.2	6.4	1.4e-10	-0.07	0.08	0.46	TRUE
91	The Cancer Genome Atlas	Thyroid Carcinoma	CDK2AP1	0.08	0.10	lasso	2	0.10	1.3e-09	-5.4	5.4	6.3e-08	0.03	0.01	0.99	FALSE
92	The Cancer Genome Atlas	Thyroid Carcinoma	SPPL3	0.04	0.05	enet	7	0.03	6.6e-04	-7.8	7.8	9.0e-15	0.88	0.09	0.87	FALSE