[Hub]/) : Traits : Breast Cancer : ← →

chr7:90,874,777-92,571,165

Best TWAS P=5.21e-11 · Best GWAS P=5.13e-11 conditioned to 0.26

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CYP51A1	0.05	0.08	lasso	5	0.06	2.4e-08	-6.5	6.6	5.2e-11	-0.94	0.07	0.93	TRUE
2	CommonMind	Brain Pre-frontal Cortex	KRIT1	0.04	0.01	blup	318	0.02	1.2e-03	-6.1	6.3	3.6e-10	-0.81	0.08	0.86	FALSE
3	GTEx	Artery Aorta	AC000120.7	0.06	0.09	lasso	4	0.08	3.4e-05	-6.5	6.5	9.4e-11	-0.97	0.07	0.92	FALSE
4	GTEx	Artery Coronary	AC000120.7	0.07	0.04	lasso	4	0.02	6.8e-02	-5.5	5.7	1.3e-08	-0.90	0.10	0.55	FALSE
5	GTEx	Artery Tibial	AC000120.7	0.08	0.06	lasso	4	0.06	3.2e-05	-6.0	6.1	1.1e-09	-0.91	0.09	0.91	FALSE
6	GTEx	Brain Cortex	AC000120.7	0.12	0.08	enet	16	0.07	7.0e-03	-6.5	6.3	2.6e-10	-0.79	0.06	0.57	FALSE
7	GTEx	Cells Transformed fibroblasts	AC000120.7	0.04	0.05	lasso	4	0.04	5.2e-04	-5.5	6.1	1.3e-09	-0.91	0.08	0.90	FALSE
8	GTEx	Colon Sigmoid	AC000120.7	0.09	0.08	lasso	3	0.07	2.2e-03	-6.0	5.4	6.4e-08	-0.81	0.09	0.71	FALSE
9	GTEx	Colon Transverse	KRIT1	0.32	0.00	lasso	8	0.00	3.7e-01	-6.5	5.2	1.6e-07	-0.90	0.06	0.44	FALSE
10	GTEx	Colon Transverse	AC000120.7	0.09	0.04	lasso	5	0.01	9.4e-02	-6.5	6.4	1.7e-10	-0.97	0.07	0.71	FALSE
11	GTEx	Esophagus Mucosa	AKAP9	0.04	0.03	lasso	15	0.02	2.7e-02	-6.5	-6.4	1.6e-10	0.97	0.07	0.91	FALSE
12	GTEx	Heart Atrial Appendage	AKAP9	0.06	0.01	enet	11	0.02	4.5e-02	-6.1	5.7	1.3e-08	-0.91	0.10	0.69	FALSE
13	GTEx	Lung	AC000120.7	0.04	0.03	lasso	3	0.01	4.8e-02	-6.5	6.4	1.2e-10	-0.96	0.08	0.84	FALSE
14	GTEx	Muscle Skeletal	CYP51A1	0.10	0.18	enet	21	0.17	5.0e-16	-6.0	6.2	7.0e-10	-0.95	0.18	0.82	FALSE
15	GTEx	Muscle Skeletal	AC000120.7	0.05	0.01	enet	10	0.01	5.4e-02	-6.4	5.3	1.3e-07	-0.79	0.07	0.74	FALSE
16	GTEx	Nerve Tibial	AKAP9	0.03	0.05	lasso	2	0.03	2.7e-03	-6.4	-6.3	2.2e-10	0.94	0.07	0.85	FALSE
17	GTEx	Pancreas	AC000120.7	0.05	0.03	enet	12	0.02	4.4e-02	-4.5	5.6	2.3e-08	-0.88	0.09	0.70	FALSE
18	GTEx	Prostate	AC000120.7	0.13	0.09	lasso	3	0.09	2.8e-03	-6.1	6.1	9.1e-10	-0.93	0.07	0.52	FALSE
19	GTEx	Spleen	AC000120.7	0.10	0.07	lasso	5	0.04	3.9e-02	-6.5	6.2	5.9e-10	-0.98	0.06	0.60	FALSE
20	GTEx	Thyroid	AC000120.7	0.04	0.01	lasso	6	0.02	2.2e-02	-6.0	6.2	5.6e-10	-0.82	0.09	0.73	FALSE
21	ROSMAP	Brain Pre-frontal Cortex	CYP51A1	0.04	0.02	blup	287	0.03	4.7e-05	-5.5	6.3	3.0e-10	-0.82	0.12	0.88	FALSE
22	YFS	Blood	CYP51A1	0.03	0.06	blup	288	0.05	1.2e-16	-6.5	6.4	1.8e-10	-0.93	0.09	0.91	FALSE
23	The Cancer Genome Atlas	Breast Invasive Carcinoma	CYP51A1	0.01	0.02	blup	51	0.02	2.0e-04	-6.3	6.3	3.3e-10	-0.96	0.03	0.95	FALSE
24	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CYP51A1	0.04	0.05	blup	51	0.05	9.4e-07	-6.3	6.3	2.5e-10	-0.96	0.03	0.97	FALSE
25	The Cancer Genome Atlas	Brain Lower Grade Glioma	CYP51A1	0.01	0.01	blup	51	0.01	1.2e-02	-6.4	6.3	2.6e-10	-0.96	0.02	0.76	FALSE
26	The Cancer Genome Atlas	Lung Adenocarcinoma	CYP51A1	0.03	0.03	enet	12	0.03	1.2e-04	-4.8	5.4	6.7e-08	-0.86	0.06	0.87	FALSE
27	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	LOC401387	0.04	0.00	lasso	1	0.00	1.6e-01	-6.0	-6.0	2.2e-09	0.93	0.02	0.75	FALSE
28	The Cancer Genome Atlas	Prostate Adenocarcinoma	MTERF	0.03	0.03	blup	47	0.04	1.2e-04	-4.2	-5.2	2.6e-07	0.85	0.03	0.94	FALSE