Hub : Genes

AKAP9

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.0430	0.0220	0.0016	0.028	NA	0.002	NA	0.016	0.00580	NA	0.210	NA	0.0270
2	GTEx	Heart Atrial Appendage	0.0580	0.0330	0.0042	0.008	NA	0.019	NA	-0.006	0.13000	NA	0.045	NA	0.9600
3	GTEx	Nerve Tibial	0.0317	0.0181	0.0055	0.049	NA	0.019	NA	0.031	0.00022	NA	0.015	NA	0.0027
4	GTEx	Whole Blood	0.1280	0.0460	0.0008	-0.003	NA	0.008	NA	-0.003	0.72000	NA	0.051	NA	0.7500
5	ROSMAP	Brain Pre-frontal Cortex	0.0415	0.0207	0.0016	-0.001	0.012	0.003	0.011	0.001	0.57000	0.0086	0.130	0.012	0.2600

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.7	1.1	2.1	-1.4	1.4	-1.1	0.4	0.1
Bipolar Disorder or Schizophrenia	0.2	0.6	1.4	0.1	0.4	0.3	1.1	-1.2
Depressed Affect (Nagel 2018)	0.2	0.5	1.1	-0.6	0.2	-0.8	-0.5	1.1
Depression (Nagel 2018)	0.7	1.0	1.9	-1.1	1.0	-1.4	0.8	-0.1
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.9	0.5	-0.3	0.5	0.9	0.2
Neuroticism (Nagel 2018)	0.2	0.6	1.3	0.7	-1.2	0.7	-0.7	-0.2
Schizophrenia (2018)	0.7	1.5	2.7	1.2	-0.6	1.3	1.1	-1.6
Schizophrenia vs Biploar Disorder	4.8	6.3	10.1	3.2	-2.8	3.1	-0.8	-1.9
Worry (Nagel 2018)	0.4	0.8	1.2	0.5	-1.0	0.7	-1.0	-1.1
Alzheimer’s Disease (in mother)	5.0	5.8	10.3	-2.6	1.8	-2.9	0.8	3.2
Alzheimer’s Disease (in father)	0.5	0.6	0.9	-0.9	0.8	-1.0	0.3	0.5
Alzheimer’s Disease (including proxy)	6.0	8.7	14.4	-3.2	2.3	-3.7	0.7	3.8
Crohns Disease (2017)	0.9	1.9	4.7	-1.3	1.3	-1.2	2.2	-0.2
Irritable Bowel Disease (IBD)	1.4	3.4	8.7	-1.5	1.1	-1.5	2.9	1.5
Ulcerative Colitis (UC)	0.9	1.8	6.4	-0.6	0.2	-0.4	2.5	1.4
Major Depression (MDD)	2.3	2.8	6.1	-1.8	2.5	-2.1	-0.4	0.2
Reaction Time	2.2	4.2	6.1	2.2	-2.5	2.2	-2.1	-0.9
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.4	0.6	-0.5	0.6	0.2	0.5
Breast Cancer	11.5	27.6	40.9	-6.4	5.7	-6.3	-0.1	4.9
Ovarian Cancer	0.5	0.7	1.7	0.9	-0.5	0.8	-1.3	-0.3
Prostate Cancer	1.2	1.8	3.7	1.6	-1.9	1.4	0.0	-0.7
Age at First Birth	0.6	0.9	1.5	1.0	-0.9	0.9	0.7	-1.2
Bipolar Disorder (2011)	0.1	0.1	0.3	-0.1	0.2	0.0	-0.0	-0.6
Body Mass Index (BMI) (2010)	0.2	0.2	0.4	0.2	-0.5	0.6	-0.4	0.5
Coronary Artery Disease (CAD)	1.0	1.1	2.4	1.1	-1.6	1.0	-1.0	0.4
Crohns Disease (2012)	2.2	3.6	10.9	-1.6	1.5	-1.5	3.3	0.1
Mean Putamen Volume	3.3	3.8	5.8	2.4	-2.2	2.1	-1.9	-0.5
Fasting Glucose	0.4	0.5	2.3	0.0	-0.0	-0.4	-1.5	0.1
HbA1C	0.2	0.3	0.6	-0.5	0.4	-0.6	-0.7	0.2
HDL Cholesterol	0.4	0.6	2.5	0.5	-0.0	0.6	-0.1	-1.6
LDL Cholesterol	0.8	1.2	1.8	-1.2	1.1	-1.3	-0.1	1.3
Lupus	1.1	1.7	3.2	-1.1	1.0	-1.7	-0.4	1.8
Neuroticism (2016)	1.9	2.7	4.8	-2.2	2.1	-1.8	0.9	0.4
Primary Biliary Cirrhosis	0.7	1.0	2.7	0.6	-0.5	1.1	1.6	-0.7
Rheumatoid Arthritis	0.1	0.1	0.2	-0.2	-0.3	-0.3	-0.3	0.5
Schizophrenia (2014)	0.9	1.9	3.1	1.6	-1.4	1.7	0.2	-1.5
Triglycerides	0.9	1.4	4.1	-0.4	-0.1	-0.9	-1.5	2.0
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.1	0.7	-1.4	0.4	-1.0	0.4
Ulcerative Colitis	2.3	3.3	10.9	-1.6	0.9	-1.3	3.3	0.8
Blood Eosinophil Count	3.7	28.8	47.6	6.0	-4.8	6.1	0.1	-6.9
Blood Platelet Count	1.3	14.7	23.6	-4.5	4.5	-4.9	0.4	2.9
Blood Red Count	4.9	46.9	68.1	-8.2	8.1	-8.2	4.6	3.5
Blood White Count	0.8	5.8	9.8	-2.8	3.1	-3.0	1.5	0.0
Heel T-Score	3.5	27.8	38.9	-6.2	5.7	-6.1	2.0	5.0
BMI	0.0	0.1	0.3	-0.2	0.4	0.3	0.1	-0.5
Height	3.0	57.3	71.1	8.1	-8.0	8.4	-7.0	-6.0
Waist Hip Ratio (WHR)	0.1	0.5	1.4	0.6	0.0	0.7	-1.2	-0.7
Systolic Blood Pressure	2.9	14.5	21.0	-4.3	4.6	-4.4	3.0	2.1
Smoking Status	1.1	2.6	10.2	0.3	-1.0	0.3	-3.2	1.4
Allergy or Eczema	0.3	0.8	1.4	-0.9	1.1	-0.7	-0.1	-1.2
Cardiovascular Disease	0.8	2.6	3.7	-1.6	1.5	-1.9	1.5	1.4
Hypothyroidism (self reported)	0.3	0.7	1.3	0.7	-1.0	1.1	0.0	-0.9
Respiratory disease	0.3	0.7	1.3	-0.5	0.5	-0.9	-0.9	-1.2
Type 2 Diabetes (T2D) (2018)	2.4	4.4	7.0	-2.6	2.0	-2.6	0.1	2.1
Lung FEV1/FVC ratio	0.3	1.7	6.4	-0.6	0.0	0.1	2.5	1.3
Lung FVC	2.3	11.6	17.7	-3.8	3.2	-4.2	1.6	3.5
Neuroticism	0.2	0.5	1.3	0.5	-0.5	0.6	-1.1	-0.7
Chronotype (morning person)	3.4	7.9	13.0	-3.3	3.6	-3.4	0.6	1.9
Hair Pigment	0.6	16.0	26.2	-3.9	4.5	-4.2	5.1	-0.7
Tanning	0.1	0.7	1.3	-1.2	0.9	-0.8	-0.3	0.7
Hand grip strength (left)	0.1	0.3	0.6	0.5	-0.4	0.4	0.8	-0.5
Number of treatments/medications taken	1.8	3.3	5.4	-1.8	1.8	-1.7	-2.3	1.3
Average weekly spirits intake	0.2	0.2	0.3	-0.5	0.5	-0.5	-0.4	0.5
Sensitivity / hurt feelings	0.1	0.2	0.3	-0.1	0.6	0.5	0.6	-0.1
Frequency of depressed mood in last 2 weeks	0.8	1.1	1.9	-1.2	1.4	-1.1	0.5	-0.9
Hearing difficulty/problems: Yes	1.1	1.6	6.2	0.8	-0.6	0.3	-2.5	-0.8
Relative age of first facial hair	1.2	2.5	4.5	1.6	-1.2	2.1	-1.9	-0.3
Other serious medical condition/disability diagnosed by doctor	1.3	1.6	3.3	-1.6	1.5	-1.8	0.4	-0.0
Ever used hormone-replacement therapy (HRT)	5.9	7.5	13.2	-3.1	3.6	-3.6	-0.7	0.9
Ever had hysterectomy (womb removed)	2.3	2.6	4.8	-1.7	2.2	-2.2	0.3	-0.4
Systolic blood pressure, automated reading	3.6	10.5	18.8	-3.8	4.3	-3.4	2.7	0.8
Eye problems/disorders: Diabetes related eye disease	2.0	2.2	2.9	-1.7	1.4	-1.6	1.4	1.4
Angina	1.5	1.9	2.9	-1.5	1.5	-1.7	-0.1	1.4
Medication for hormone replacement therapy	6.8	7.6	13.0	-3.3	2.9	-3.6	-1.2	2.2
Vitamin and mineral supplements	1.3	1.8	2.9	1.6	-1.6	1.7	0.2	-0.9
Supplements: Zinc	2.9	3.1	5.9	-2.3	2.4	-1.9	0.2	0.9
Medication: Co-codamol	0.5	0.6	0.8	-0.8	0.9	-0.8	0.9	0.0
Medication: Metformin	4.9	7.0	10.6	-3.2	2.8	-3.3	0.0	2.4
Diabetes (father)	0.2	0.2	0.4	-0.4	0.6	-0.6	0.3	-0.5
Diabetes (mother)	0.5	0.6	1.3	-0.9	0.9	-1.1	-0.2	0.4
Severe depression (siblings)	1.3	1.5	1.9	-1.4	1.3	-1.3	1.0	1.0
Pack years adult smoking proportion	0.2	0.3	0.4	0.5	-0.6	0.5	-0.6	-0.2
Impedance of leg (right)	0.2	0.7	1.8	-0.8	0.5	-1.0	1.3	0.4
Leg fat-free mass (left)	2.3	12.3	16.1	3.9	-3.6	4.0	-2.8	-3.0
Trunk fat percentage	0.1	0.4	0.9	-0.5	0.7	-0.0	0.6	-1.0
Hand grip strength (right)	0.1	0.2	0.6	0.3	-0.1	0.3	-0.4	-0.8
Townsend deprivation index at recruitment	0.2	0.3	0.6	0.7	-0.5	0.6	-0.8	-0.1
Current tobacco smoking	0.6	1.0	3.6	-0.2	-0.1	-0.1	-1.9	1.1
Average weekly fortified wine intake	0.6	0.7	2.7	-0.5	0.4	-0.3	-1.7	0.6
Maternal smoking around birth	0.3	0.5	1.1	0.7	0.0	0.8	-0.2	-1.1
Fed-up feelings	0.3	0.6	2.1	0.3	-0.6	0.1	-1.5	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.4	0.3	0.0	0.2	0.1	-0.6
Relative age voice broke	0.7	1.1	2.2	0.9	-0.3	1.5	-1.5	-0.2
Taking other prescription medications	0.7	1.0	3.0	-0.3	0.7	-0.5	-1.7	-1.1
Age when periods started (menarche)	0.4	0.9	1.3	1.0	-1.0	0.9	0.3	-1.2
Bilateral oophorectomy (both ovaries removed)	8.6	9.9	17.3	-3.8	4.2	-3.8	-0.9	1.7
Heel bone mineral density (BMD) T-score, automated (left)	1.3	2.9	4.0	-1.8	1.8	-2.0	-0.5	2.0
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.9	0.6	-0.3	0.5	1.0	-1.4
Qualifications: CSEs or equivalent	0.6	0.8	2.9	0.5	0.3	0.8	0.2	-1.7
Serious illness, injury or assault to yourself	3.1	3.8	6.3	-2.2	2.5	-2.5	1.2	0.5
High blood pressure	1.1	3.0	4.9	-2.1	2.1	-2.2	0.7	0.7
Hayfever, allergic rhinitis or eczema	0.1	0.2	1.1	-0.2	0.1	-0.1	0.0	-1.0
Multivitamins +/- minerals	1.9	2.4	4.2	-1.8	1.5	-2.0	-0.7	1.4
Stomach or abdominal pain in last month	1.0	1.3	2.3	-1.4	1.3	-1.5	0.4	-0.6
Supplements: Glucosamine	0.9	1.2	2.0	-1.3	1.3	-1.4	0.2	0.7
Diverticular disease/diverticulitis (self-reported)	2.5	3.0	4.4	-1.9	1.3	-1.8	2.1	1.4
Medication: Atenolol	0.4	0.5	0.8	-0.5	0.5	-0.6	-0.9	0.9
Medication: Levothyroxine sodium	2.6	4.4	8.1	2.4	-1.8	2.8	0.4	-2.2
Sitting height	1.6	11.6	14.2	3.8	-3.7	3.8	-3.0	-2.6
Chronic bronchitis/emphysema (father)	0.6	0.7	2.2	0.2	-0.5	0.5	1.5	-1.0
High blood pressure (mother)	0.3	0.4	1.5	-0.2	0.6	-0.1	0.4	-1.2
Body mass index (BMI)	0.0	0.1	0.2	0.0	0.3	0.3	0.2	-0.4
Impedance of leg (left)	0.5	2.6	5.0	-1.5	1.3	-1.8	2.2	0.9
Leg predicted mass (left)	2.3	12.4	16.4	4.0	-3.6	4.0	-2.8	-3.1
Trunk fat mass	0.2	1.0	2.5	0.8	-0.6	1.2	-0.4	-1.6
Waist circumference	0.3	1.1	1.8	1.0	-0.6	1.4	-0.6	-1.3
Number of incorrect matches in round	1.3	2.2	3.3	-1.8	1.6	-1.6	-0.9	1.4
Past tobacco smoking	2.1	3.8	13.9	-1.1	1.5	-1.3	3.7	-0.1
Alcohol usually taken with meals	2.3	3.7	4.8	-2.1	2.2	-2.2	2.1	-0.5
Nervous feelings	1.3	2.4	3.3	1.5	-1.8	1.8	-1.2	-1.4
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.3	-0.5	0.6	-0.4	0.0	-0.6
Hearing difficulty/problems with background noise	0.4	0.7	1.1	0.7	-1.0	0.8	-1.1	0.0
Hair/balding pattern: Pattern 2	1.8	2.3	3.5	1.4	-1.4	1.3	1.6	-1.9
Had menopause	0.4	0.6	0.8	-0.7	0.6	-0.7	-0.7	0.9
Had other major operations	1.6	2.0	4.9	-1.5	2.2	-1.4	0.4	-0.7
Forced vital capacity (FVC)	0.2	0.8	1.6	-1.0	0.8	-1.3	-0.2	0.9
Heel bone mineral density (BMD) T-score, automated (right)	1.8	4.2	6.5	-2.2	2.4	-2.5	-0.1	2.0
Ever unenthusiastic/disinterested for a whole week	5.3	6.5	10.3	-3.0	2.6	-3.2	1.0	2.4
Qualifications: None of the above	1.8	3.8	5.3	-2.2	2.3	-2.2	0.3	2.0
Financial difficulties in last 2 years	6.8	9.1	15.6	-3.4	2.9	-4.0	-0.1	3.1
Mouth/teeth dental problems	0.7	1.1	2.2	-1.1	1.5	-1.4	-0.4	0.2
Heart attack	0.3	0.4	0.8	-0.6	0.9	-0.9	-0.2	-0.5
Allergy	0.3	0.6	0.8	0.9	-0.8	0.9	0.1	0.9
Pain all over the body in last month	0.4	0.4	1.9	-0.0	-0.2	0.3	0.3	1.4
Diabetes (self-reported)	4.0	6.2	9.7	-3.1	2.5	-2.9	-0.1	2.6
Hayfever/allergic rhinitis (self-reported)	1.0	1.4	2.6	-1.4	1.2	-1.6	0.9	0.2
Medication: Ramipril	0.8	1.0	2.8	-0.9	1.0	-0.7	-1.7	-0.2
Medication: Simvastatin	0.3	0.5	1.1	-0.7	0.6	-0.6	-1.0	0.3
Fluid intelligence score	0.4	0.9	2.1	1.2	-1.4	0.9	0.5	0.3
Illnesses of siblings	1.5	2.0	3.8	1.8	-1.9	1.4	-0.2	-1.0
Neuroticism score	0.1	0.1	0.3	-0.1	-0.0	0.1	-0.6	-0.5
Weight	0.9	4.4	6.3	2.3	-1.9	2.5	-1.4	-2.2
Impedance of arm (right)	0.1	0.3	1.0	-0.5	0.4	-0.4	1.0	0.3
Arm fat percentage (right)	0.1	0.3	0.7	-0.2	0.7	0.3	0.3	-0.8
Trunk fat-free mass	3.3	19.0	25.5	5.0	-4.6	4.9	-3.5	-3.5
Hip circumference	0.4	1.7	2.8	1.3	-1.0	1.7	0.4	-1.7
Time employed in main current job	0.9	1.0	3.1	0.5	-1.3	0.1	-1.8	0.2
Alcohol intake versus 10 years previously	5.5	8.2	11.5	-3.1	3.3	-3.4	-0.2	3.0
Father’s age at death	0.9	1.2	1.9	-1.3	1.1	-1.4	0.6	0.9
Worrier / anxious feelings	0.1	0.1	0.3	-0.3	-0.2	0.3	-0.3	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	2.1	-0.7	1.4	-0.6	0.4	-0.4
Falls in the last year	0.7	0.9	1.9	-1.4	1.2	-0.9	-0.2	0.5
Hair/balding pattern: Pattern 3	0.1	0.1	0.3	0.1	-0.1	0.5	0.4	-0.4
Number of live births	0.4	0.6	1.9	-1.0	1.4	-0.3	-0.2	0.3
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	1.4	-1.1	0.7	-1.2	0.8	1.1
Pulse rate	0.3	0.6	1.8	0.1	-0.8	0.5	-0.4	1.4
Happiness	1.2	1.5	2.4	-1.6	0.5	-1.3	1.3	1.1
Noisy workplace	1.4	1.7	3.4	-1.5	1.8	-1.1	1.2	-0.5
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.5	-0.2	-0.4	-0.3	0.2	-0.7
Serious illness, injury or assault of a close relative in last 2 years	1.7	1.9	2.8	-1.5	1.1	-1.7	0.9	1.6
Mouth/teeth dental problems: Dentures	1.5	2.6	4.6	-1.9	1.5	-1.5	0.2	2.1
Asthma	0.8	1.7	2.5	-1.5	1.4	-1.6	-1.3	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.1	0.8	-0.3	0.6	0.5	-1.1
Medication: Cholesterol lowering	1.0	1.5	2.8	-1.4	1.3	-1.7	-0.0	0.9
Depression (self-reported)	0.2	0.2	0.6	-0.4	0.5	-0.3	0.8	0.2
Medication: Lansoprazole	8.7	9.9	18.8	-4.3	4.1	-3.5	0.0	1.5
Prospective memory result	0.8	1.0	4.5	0.3	-0.1	0.6	2.1	0.1
Lung cancer (father)	0.8	0.9	1.6	1.3	-1.1	1.2	-0.4	-0.1
Illnesses of mother	0.4	0.5	0.8	0.8	-0.9	0.5	-0.8	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	2.1	-0.8	0.1	-0.8	0.3	1.4
Pulse wave Arterial Stiffness index	0.4	0.4	0.9	0.5	-0.3	0.6	-0.6	-1.0
Impedance of arm (left)	0.2	0.8	1.2	-1.1	1.0	-0.9	1.0	0.3
Arm fat mass (right)	0.3	1.2	2.3	1.1	-0.6	1.4	-0.5	-1.5
Trunk predicted mass	3.3	18.9	25.4	5.0	-4.6	4.9	-3.5	-3.5
Standing height	2.1	20.3	25.5	5.0	-4.8	5.0	-3.7	-3.9
Length of working week for main job	4.0	4.5	7.4	-2.4	1.8	-2.7	-0.2	2.5
Exposure to tobacco smoke at home	0.2	0.3	1.0	0.1	-0.3	-0.4	0.3	1.0
Breastfed as a baby	1.1	1.4	5.0	-0.2	0.3	-0.1	-2.2	-1.3
Tense / ‘highly strung’	0.9	1.4	3.2	-1.3	1.8	-1.3	-0.1	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.3	2.8	-1.0	1.7	-1.6	-0.6	-0.3
Hair/balding pattern: Pattern 4	0.8	2.1	3.0	-1.5	1.6	-1.7	-0.5	1.5
Birth weight of first child	1.2	2.2	3.2	1.8	-1.8	1.3	-1.7	-0.3
Peak expiratory flow (PEF)	1.1	2.5	3.9	-1.7	2.0	-1.5	1.8	-0.3
Pulse wave reflection index	0.4	0.5	2.2	-0.1	0.3	0.1	-0.1	-1.5
Ever highly irritable/argumentative for 2 days	1.5	1.8	3.5	-1.4	0.5	-1.0	1.9	1.5
Loud music exposure frequency	1.6	1.7	4.4	1.2	-1.0	1.3	0.1	-2.1
Qualifications: O levels/GCSEs or equivalent	1.8	2.9	5.1	2.1	-2.2	1.4	-1.4	-1.1
Mouth/teeth dental problems: Bleeding gums	6.9	8.9	13.8	3.4	-3.7	3.2	-0.6	-2.9
Blood clot in the leg (DVT)	0.1	0.2	0.5	0.3	-0.4	-0.2	-0.7	-0.4
Medication: Paracetamol	1.7	2.8	5.1	-2.3	1.5	-1.7	-0.8	1.7
Headache pain in last month	0.5	0.9	2.7	0.8	-0.5	0.9	0.2	-1.7
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	0.9	0.8	-0.7	0.9	0.7	-0.7
Glaucoma (self-reported)	1.1	1.3	3.1	0.5	0.4	0.7	-1.8	-1.6
Gout (self-reported)	0.5	0.7	1.3	1.2	-0.9	1.1	-0.3	-0.4
Hypothyroidism/myxoedema (self-reported)	0.7	1.5	3.2	1.2	-1.2	1.8	0.3	-0.9
Medication: Amlodipine	0.3	0.5	1.8	0.1	-0.1	0.3	-1.4	0.7
Medication: Ventolin 100micrograms inhaler	0.9	1.1	3.8	0.3	0.2	0.3	-2.0	-1.2
Birth weight	0.2	0.4	0.7	-0.9	0.8	-0.8	0.0	-0.0
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.2	-1.1	1.0	-0.7	-0.1	0.4
High blood pressure (siblings)	0.6	0.9	2.3	-1.1	1.5	-1.0	0.4	0.4
Forced vital capacity (FVC), Best measure	0.1	0.3	0.6	-0.5	0.3	-0.7	-0.6	0.8
Body fat percentage	0.1	0.4	0.7	-0.7	0.8	-0.3	0.5	-0.5
Leg fat percentage (right)	0.1	0.3	1.0	-0.5	0.6	-0.1	1.0	-0.2
Arm fat-free mass (right)	1.8	9.1	12.2	3.5	-3.1	3.2	-2.5	-2.6
Exposure to tobacco smoke outside home	1.8	2.4	5.9	1.9	-2.4	1.4	-0.3	0.5
Comparative body size at age 10	2.5	6.8	10.3	3.2	-2.3	3.1	-1.6	-2.5
Number of full brothers	0.9	1.1	1.6	1.3	-1.2	1.1	-0.9	-0.8
Worry too long after embarrassment	1.5	2.5	4.3	1.3	-1.6	1.5	-1.3	-2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	4.4	5.7	10.0	-2.9	2.6	-3.2	0.7	1.8
Wheeze or whistling in the chest in last year	0.3	0.5	2.1	0.4	-0.3	0.1	0.4	-1.4
Number of children fathered	0.7	0.8	1.3	-1.0	0.6	-1.0	-0.4	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.7	3.0	1.7	-1.5	1.7	-0.0	-0.3
Age at first live birth	1.9	3.3	5.2	2.1	-2.3	1.6	-1.8	-1.1
Pulse wave peak to peak time	0.1	0.1	0.6	-0.0	-0.1	-0.2	0.2	0.8
Health satisfaction	0.2	0.3	0.7	-0.5	0.6	-0.1	-0.8	0.4
Shortness of breath walking on level ground	0.1	0.2	0.5	0.3	0.0	0.4	0.3	-0.7
Qualifications: College or University degree	0.4	1.4	4.7	0.8	-1.0	0.7	-0.4	-2.2
Eye problems/disorders: None of the above	0.9	1.1	4.1	-0.8	0.1	-0.7	0.5	2.0
Mouth/teeth dental problems: Loose teeth	0.5	0.6	2.7	0.2	-0.3	-0.1	-1.6	0.1
Emphysema/chronic bronchitis	0.1	0.1	0.2	-0.3	0.1	-0.5	0.4	0.1
Medication for pain relief, constipation, heartburn	0.4	0.7	1.2	1.1	-0.8	0.8	0.7	-0.8
Neck or shoulder pain in last month	0.7	1.0	4.7	0.1	0.1	0.1	0.6	-2.2
Medication: Blood pressure	0.6	1.0	2.7	-0.6	0.6	-0.7	-1.6	1.1
Angina (self-reported)	1.8	2.4	4.0	-1.8	1.8	-2.0	-0.3	1.1
Migraine (self-reported)	0.5	0.7	1.7	-0.1	0.6	-0.6	-0.9	-1.3
Medication: Ibuprofen	0.2	0.3	0.8	0.3	0.3	0.3	0.4	-0.9
Medication: Allopurinol	0.1	0.1	0.3	0.6	-0.3	0.3	-0.3	0.2
Medication: Omeprazole	1.2	1.4	2.6	1.6	-1.2	1.4	0.8	-0.7
Medication: Seretide 50 evohaler	4.1	4.7	9.5	-2.6	2.1	-3.1	-1.1	1.2
Mean time to correctly identify matches	1.6	3.0	4.2	1.7	-1.9	2.0	-1.9	-0.8
Heart disease (mother)	0.4	0.5	1.0	0.6	-1.0	0.8	-0.8	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	2.4	-1.5	1.1	-1.3	0.9	0.8
Whole body fat mass	0.2	1.0	2.5	0.8	-0.5	1.2	-0.4	-1.6
Leg fat mass (right)	0.2	0.8	1.5	0.8	-0.5	1.1	-0.4	-1.2
Arm predicted mass (right)	2.1	10.7	13.9	3.7	-3.5	3.5	-3.0	-2.6
Pulse rate, automated reading	1.3	4.1	6.3	2.1	-1.8	2.5	-1.2	-2.2
Alcohol intake frequency.	2.1	4.8	7.7	-2.5	2.8	-2.8	1.3	0.9
Comparative height size at age 10	1.6	8.6	11.0	3.3	-3.1	3.2	-1.1	-3.3
Number of full sisters	0.3	0.4	1.1	-0.7	1.1	-0.5	0.1	0.3
Suffer from ‘nerves’	1.1	1.7	4.9	0.8	-1.4	0.9	-2.2	-0.8
Overall health rating	1.1	2.4	4.4	-1.8	1.8	-2.1	-0.3	0.9
Chest pain or discomfort	0.2	0.3	1.5	-0.1	0.2	-0.1	0.2	-1.2
Had major operations	2.4	2.9	5.4	-2.1	2.3	-2.1	-0.2	0.3
Age at last live birth	0.8	1.1	1.6	1.2	-0.8	1.3	-1.0	-1.0
Family relationship satisfaction	0.1	0.1	0.3	0.5	-0.6	0.2	0.4	-0.1
Leg pain on walking	0.4	0.6	1.1	-1.0	0.6	-0.8	0.4	0.7
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.3	3.4	1.9	-1.4	1.8	0.9	-1.5
Commuting to job workplace: Car/motor vehicle	0.6	0.6	1.5	-1.1	0.4	-1.2	-0.3	0.5
Illness, injury, bereavement, stress in last 2 years	3.5	4.2	8.0	2.3	-1.6	2.8	-0.6	-2.2
Medication: Aspirin	1.6	2.2	3.2	-1.4	1.3	-1.2	-1.6	1.8
Supplements: Vitamin C	2.2	2.6	6.5	-1.9	2.5	-1.6	0.1	0.2
Knee pain experienced in last month	1.1	1.6	4.4	-1.0	2.1	-1.3	-0.5	-0.8
Hypertension (Self-reported)	1.0	2.7	4.4	-2.0	2.1	-2.1	0.8	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.6	-0.6	0.7	-0.3	0.8	-0.4
Illnesses of father: Heart disease	0.6	0.8	1.6	1.0	-0.6	0.8	-1.3	-0.7
Illnesses of siblings: Diabetes	3.8	4.7	7.3	-2.7	2.5	-2.5	1.7	1.1
Smoking status: Previous	1.0	1.5	6.8	0.2	-0.5	0.5	-2.6	0.5
Forced expiratory volume in 1-second (FEV1), predicted	2.7	5.7	9.0	3.0	-2.5	2.8	-1.4	-1.9
Whole body fat-free mass	2.8	15.7	20.6	4.5	-4.1	4.4	-3.2	-3.4
Leg fat-free mass (right)	1.9	10.0	13.1	3.6	-3.3	3.6	-2.5	-2.7
Arm fat percentage (left)	0.1	0.2	0.5	-0.3	0.7	0.1	0.1	-0.6
Average weekly red wine intake	0.1	0.2	0.7	-0.4	0.2	0.2	0.8	-0.0
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.2	0.4	0.0	0.4	-1.1	-0.5
Mood swings	0.0	0.0	0.1	-0.0	0.3	0.1	0.0	0.0
Loneliness, isolation	3.2	4.4	7.1	-2.2	2.4	-2.7	0.1	2.0
Long-standing illness, disability or infirmity	0.7	1.1	2.2	-1.2	1.2	-1.5	-0.8	0.2
Ever had bowel cancer screening	0.4	0.5	1.3	-0.1	0.4	0.2	1.1	-0.9
Diabetes diagnosed by doctor	4.1	6.7	9.6	-3.1	2.5	-3.0	-0.5	3.0
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	1.7	-0.9	1.3	-0.7	-1.2	0.3
Friendships satisfaction	0.1	0.1	0.3	-0.1	-0.0	-0.1	0.6	0.3
Qualifications: nursing, teaching	0.4	0.6	1.4	0.1	-0.4	0.4	-1.1	-1.2
Commuting to job workplace: Walk	0.2	0.2	0.6	0.3	-0.6	-0.0	-0.4	0.7
Eye problems/disorders: Cataract	0.2	0.2	0.7	-0.3	0.8	-0.4	-0.0	-0.2
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	7.7	0.4	-0.5	1.0	2.8	-0.5
Medication for cholesterol	2.5	3.9	6.5	2.3	-2.5	2.5	-0.9	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.0	2.3	3.8	1.4	-0.9	1.5	-1.7	-2.0
Back pain experienced in last month	1.0	1.4	2.7	-1.2	1.6	-1.6	0.6	-0.2
Mineral and other dietary supplements	0.4	0.5	0.9	0.7	-1.0	0.5	-0.9	-0.0
Breast cancer (self-reported)	5.7	6.9	10.4	2.9	-2.1	3.2	-1.4	-3.0
Asthma (self-reported)	0.9	1.7	2.6	-1.4	1.3	-1.6	-1.6	-0.1
Osteoporosis (self-reported)	0.1	0.1	0.3	-0.1	-0.2	0.5	-0.0	-0.3
Osteoarthritis (self-reported)	0.7	1.0	1.4	-1.0	1.2	-1.1	-0.7	0.8
Medication: Aspirin	2.0	2.7	3.8	-1.6	1.5	-1.4	-1.6	1.9
Medication: Gliclazide	0.3	0.4	0.8	-0.4	-0.0	-0.7	-0.5	0.9
Illnesses of father: None of the above (group 1)	0.2	0.3	0.9	-0.6	0.4	-0.9	-0.1	0.3
Smoking status: Current	0.8	1.3	5.4	0.4	-0.7	0.4	-2.3	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.5	8.2	-1.3	0.2	-1.1	1.3	2.9
Whole body water mass	2.7	15.5	20.7	4.5	-4.1	4.4	-3.1	-3.3
Leg predicted mass (right)	1.9	10.1	13.1	3.6	-3.2	3.6	-2.4	-2.8
Arm fat mass (left)	0.2	1.0	1.9	0.9	-0.5	1.3	-0.5	-1.4
Number of self-reported non-cancer illnesses	1.7	3.0	5.6	-1.9	2.4	-2.2	0.0	-0.9
Average weekly champagne plus white wine intake	1.4	2.0	2.7	1.6	-1.6	1.4	-0.8	-1.4
Miserableness	0.5	0.9	2.8	0.7	-0.8	0.4	-1.7	-0.7
Guilty feelings	5.1	7.6	11.5	3.4	-3.2	3.2	-1.7	-1.8
Wears glasses or contact lenses	1.9	2.2	3.6	1.5	-1.9	1.5	-1.7	0.1
Ever taken oral contraceptive pill	6.4	7.2	10.6	-3.3	3.1	-3.0	0.8	2.4
Hearing aid user	0.5	0.6	0.8	-0.9	0.8	-0.8	0.1	0.9
Mother’s age at death	0.3	0.4	1.7	-0.1	-0.2	-0.2	-1.3	0.3
Financial situation satisfaction	1.0	1.2	2.1	-1.4	0.6	-1.1	-1.0	1.2
Tinnitus: Yes, now most or all of the time	2.9	3.4	5.1	-2.2	2.3	-2.2	0.7	1.3
Commuting to job workplace: Public transport	0.4	0.5	0.8	0.5	-0.9	0.5	-0.9	0.8
Eye problems/disorders: Glaucoma	1.6	1.9	3.5	-0.6	1.7	-0.2	-1.9	-1.6
Medication: Blood pressure	0.7	1.3	2.0	-0.9	1.4	-0.9	1.3	-1.0
Pain type(s) experienced in last month: Hip pain	4.5	5.7	9.7	-3.0	3.1	-2.7	0.9	1.3
Supplements: Fish oil (including cod liver oil)	0.6	0.7	1.5	-1.0	0.9	-0.5	0.3	1.2
High cholesterol (Self-reported)	0.7	1.2	2.0	-1.1	0.9	-1.4	0.3	1.4
Medication: Bendroflumethiazide	0.4	0.6	1.2	-1.1	0.7	-0.8	0.3	0.8
Medication: Paracetamol	2.2	3.4	6.7	-2.6	1.9	-2.0	-0.3	1.7
Medication: Lisinopril	0.1	0.1	0.2	0.5	-0.4	0.2	-0.2	-0.4
Medication: Atorvastatin	0.2	0.2	0.5	-0.2	-0.2	-0.5	0.7	0.6
Illnesses of father: High blood pressure	0.2	0.3	0.7	0.1	0.6	-0.1	0.5	-0.8
Alcohol drinker status: Never	1.1	1.3	3.1	0.8	-0.5	1.0	1.2	-1.8
Ever smoked	1.9	3.3	11.6	1.1	-1.5	1.3	-3.4	-0.1
Basal metabolic rate	2.3	12.7	16.6	4.1	-3.6	4.1	-2.7	-3.2
Leg fat percentage (left)	0.2	0.6	1.8	-0.8	0.8	-0.3	1.3	0.1
Arm fat-free mass (left)	2.1	10.7	14.8	3.9	-3.4	3.6	-2.4	-2.8
Number of operations (self-reported)	4.1	6.0	13.7	-2.8	3.7	-2.7	-1.1	-0.5
Average weekly beer plus cider intake	0.4	0.5	1.0	0.5	-0.4	1.0	0.3	1.0
Irritability	0.3	0.4	2.0	0.0	0.1	-0.2	1.4	0.3
Risk taking	4.0	5.9	11.9	-2.4	3.5	-2.5	1.5	-1.7
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	0.3	0.2	0.5	0.1	-0.1
Fractured/broken bones in last 5 years	1.1	1.4	2.4	1.0	-1.6	1.1	0.0	-1.5
Age started oral contraceptive pill	0.3	0.4	1.1	-0.6	0.3	-0.2	0.5	1.0
Diastolic blood pressure, automated reading	0.3	0.9	3.5	-0.1	0.9	0.1	-0.4	-1.9
Ever depressed for a whole week	4.5	5.5	11.2	-2.9	2.4	-3.3	0.3	1.4
Unable to work because of sickness or disability	0.5	0.7	2.1	-0.2	0.2	-0.6	-0.9	1.5
Commuting to job workplace: Cycle	0.1	0.1	0.5	-0.3	-0.0	0.1	0.1	0.7
Myopia	0.7	1.0	4.3	-0.7	0.0	-0.4	-0.5	2.1
Vascular/heart problems diagnosed by doctor	0.8	2.3	3.9	1.9	-2.0	2.0	-0.2	-0.4
Cholesterol lowering medication	0.1	0.2	0.5	-0.5	0.5	-0.3	0.7	0.1
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	1.7	1.1	-0.7	1.0	1.3	-0.9
Pain experienced in last month	0.7	1.2	2.3	0.9	-1.5	1.1	0.5	1.2
Supplements: Calcium	0.9	1.0	3.4	-0.4	-0.3	-0.4	-1.8	1.2
Basal cell carcinoma (self-reported)	1.8	2.1	3.4	1.7	-1.9	1.7	-0.1	-1.1
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.4	-0.4	0.6	-0.6	-0.2	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.3	-0.2	-0.2	-0.6	-0.4	0.2
Heart disease (siblings)	0.4	0.5	1.0	-0.7	1.0	-0.9	-0.3	-0.5
Alcohol drinker status: Previous	4.0	4.5	6.1	-2.3	2.3	-2.5	-0.5	2.3
Pack years of smoking	0.1	0.2	0.2	0.4	-0.4	0.5	-0.4	-0.3
Impedance of whole body	0.5	2.4	3.2	-1.7	1.4	-1.8	1.7	0.8
Leg fat mass (left)	0.1	0.4	0.9	0.6	-0.3	0.9	-0.3	-0.9
Arm predicted mass (left)	2.1	10.5	14.5	3.8	-3.4	3.7	-2.3	-2.8