[Hub]/) : Traits : Crohns Disease (2012) : ← →

chr3:47,911,521-50,800,146

Best TWAS P=8.36e-15 · Best GWAS P=1.09e-13 conditioned to 0.106

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
50	NTR	Blood	AMT	0.02	0.01	lasso	13	0.02	5.1e-06	-7.0	7.8	8.4e-15	0.85	0.08	0.92	TRUE
36	GTEx	Nerve Tibial	RHOA-IT1	0.05	0.02	enet	14	0.03	4.7e-03	7.0	7.6	3.1e-14	0.86	0.10	0.53	FALSE
59	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	APEH	0.02	0.02	blup	49	0.02	2.5e-03	7.1	7.6	3.7e-14	0.95	0.01	0.92	FALSE
37	GTEx	Skin Sun Exposed Lower leg	MST1	0.07	0.00	enet	10	0.01	4.1e-02	7.0	7.5	7.5e-14	0.85	0.04	0.84	FALSE
16	GTEx	Cells Transformed fibroblasts	APEH	0.13	0.12	lasso	15	0.12	1.3e-09	7.1	7.4	1.6e-13	0.97	0.04	0.96	FALSE
54	ROSMAP	Brain Pre-frontal Cortex	BSN-AS2	0.07	0.10	lasso	6	0.09	3.5e-12	-7.1	7.2	4.3e-13	0.59	0.05	0.95	FALSE
33	GTEx	Muscle Skeletal	FAM212A	0.05	0.08	lasso	3	0.07	4.9e-07	7.2	-7.2	4.7e-13	-0.96	0.03	0.97	FALSE
45	GTEx	Thyroid	RHOA-IT1	0.05	0.05	lasso	5	0.04	5.2e-04	-7.1	7.2	5.9e-13	0.62	0.07	0.89	FALSE
15	GTEx	Brain Hypothalamus	MST1	0.32	0.13	lasso	3	0.12	9.4e-04	7.0	7.2	6.6e-13	0.91	0.04	0.76	FALSE
42	GTEx	Testis	GPX1	0.08	0.00	lasso	6	0.04	1.0e-02	6.9	-7.1	1.3e-12	-0.80	0.06	0.70	FALSE
72	The Cancer Genome Atlas	Thyroid Carcinoma	APEH	0.04	0.03	lasso	2	0.03	3.9e-04	6.6	6.9	3.9e-12	0.74	0.04	0.77	FALSE
2	CommonMind	Brain Pre-frontal Cortex	RNF123	0.14	0.10	blup	324	0.12	4.7e-14	-6.0	-6.9	4.0e-12	-0.69	0.98	0.02	FALSE
7	GTEx	Artery Tibial	MST1R	0.06	0.02	lasso	5	0.02	1.5e-02	-4.9	-6.9	7.0e-12	-0.76	0.13	0.36	FALSE
35	GTEx	Nerve Tibial	MST1	0.27	0.03	lasso	8	0.10	1.9e-07	3.3	6.9	7.0e-12	0.79	0.06	0.94	FALSE
9	GTEx	Brain Cerebellar Hemisphere	MST1R	0.30	0.08	enet	25	0.10	1.8e-03	-4.9	-6.8	1.2e-11	-0.69	0.17	0.43	FALSE
29	GTEx	Heart Atrial Appendage	RNF123	0.06	0.04	lasso	2	0.02	4.0e-02	-5.7	-6.7	2.6e-11	-0.85	0.15	0.57	FALSE
65	The Cancer Genome Atlas	Brain Lower Grade Glioma	TRAIP	0.02	0.01	enet	8	0.01	3.1e-02	-5.4	-6.5	9.0e-11	-0.57	0.01	0.71	FALSE
23	GTEx	Esophagus Mucosa	APEH	0.16	0.08	lasso	4	0.12	1.2e-08	4.1	6.4	1.8e-10	0.76	0.09	0.91	FALSE
62	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	GMPPB	0.09	0.05	enet	7	0.04	1.5e-03	6.7	6.3	3.0e-10	0.62	0.01	0.44	FALSE
30	GTEx	Heart Left Ventricle	AMT	0.07	0.02	lasso	7	0.02	4.6e-02	-7.0	-6.2	4.8e-10	-0.43	0.08	0.64	FALSE
44	GTEx	Thyroid	MST1	0.18	0.01	enet	11	0.05	8.1e-05	4.1	6.2	5.1e-10	0.71	0.03	0.95	FALSE
24	GTEx	Esophagus Mucosa	RNF123	0.07	0.03	enet	9	0.04	1.8e-03	-5.6	-6.2	5.4e-10	-0.64	0.47	0.24	FALSE
53	ROSMAP	Brain Pre-frontal Cortex	MST1	0.20	0.07	bslmm	307	0.08	8.8e-11	6.7	6.2	6.8e-10	0.56	0.51	0.49	FALSE
67	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	UBA7	0.02	0.01	blup	30	0.02	5.3e-03	-5.6	6.1	9.0e-10	0.63	0.03	0.68	FALSE
8	GTEx	Brain Cerebellar Hemisphere	RNF123	0.20	0.24	enet	29	0.20	7.7e-06	-5.6	-6.1	9.3e-10	-0.70	0.55	0.20	FALSE
10	GTEx	Brain Cerebellar Hemisphere	FAM212A	0.25	0.17	lasso	21	0.20	8.1e-06	4.3	-6.0	1.4e-09	-0.55	0.37	0.24	FALSE
11	GTEx	Brain Cerebellum	MST1R	0.19	0.24	enet	22	0.20	1.8e-06	4.5	-6.0	1.5e-09	-0.64	0.84	0.13	FALSE
73	The Cancer Genome Atlas	Thyroid Carcinoma	TCTA	0.04	0.04	blup	24	0.03	3.6e-04	-7.0	-6.0	1.6e-09	-0.42	0.01	0.96	FALSE
71	The Cancer Genome Atlas	Stomach Adenocarcinoma	USP4	0.05	0.03	blup	44	0.04	3.5e-04	5.0	6.0	2.0e-09	0.65	0.14	0.22	FALSE
48	METSIM	Adipose	APEH	0.09	0.06	enet	22	0.07	3.7e-11	6.7	6.0	2.1e-09	0.76	0.12	0.88	FALSE
1	CommonMind	Brain Pre-frontal Cortex	MST1	0.16	0.05	blup	314	0.07	4.0e-09	6.7	5.9	3.1e-09	0.71	0.09	0.91	FALSE
55	YFS	Blood	APEH	0.11	0.05	enet	46	0.06	1.3e-19	7.2	5.9	4.1e-09	0.77	0.03	0.97	FALSE
63	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	UBA7	0.13	0.16	lasso	6	0.15	1.1e-08	-5.7	5.9	4.4e-09	0.70	0.08	0.92	FALSE
68	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CAMKV	0.07	0.05	enet	9	0.06	2.3e-03	-5.6	-5.8	5.2e-09	-0.59	0.01	0.74	FALSE
21	GTEx	Esophagus Gastroesophageal Junction	MST1R	0.18	0.02	lasso	9	0.06	2.4e-03	-4.9	-5.8	7.3e-09	-0.57	0.11	0.32	FALSE
43	GTEx	Thyroid	RNF123	0.09	0.13	lasso	9	0.12	2.7e-09	-6.0	-5.8	7.4e-09	-0.66	1.00	0.00	FALSE
40	GTEx	Spleen	UBA7	0.19	0.14	lasso	22	0.11	8.8e-04	-5.6	5.7	9.5e-09	0.66	0.28	0.45	FALSE
18	GTEx	Cells Transformed fibroblasts	UBA7	0.07	0.06	enet	5	0.04	7.5e-04	-5.7	5.7	1.0e-08	0.67	0.95	0.01	FALSE
46	GTEx	Vagina	RBM6	0.24	0.22	enet	27	0.21	1.5e-05	4.2	5.7	1.3e-08	0.53	0.73	0.12	FALSE
69	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	UBA7	0.11	0.14	enet	7	0.11	2.7e-05	-5.6	5.7	1.3e-08	0.66	0.07	0.89	FALSE
70	The Cancer Genome Atlas	Stomach Adenocarcinoma	UBA7	0.04	0.05	lasso	1	0.04	1.0e-03	-5.7	5.7	1.5e-08	0.66	0.04	0.84	FALSE
57	YFS	Blood	UBA7	0.16	0.24	lasso	6	0.23	4.0e-75	-5.7	5.7	1.6e-08	0.67	1.00	0.00	FALSE
52	NTR	Blood	UBA7	0.02	0.03	lasso	4	0.03	1.6e-09	-5.7	5.6	2.0e-08	0.65	1.00	0.00	FALSE
66	The Cancer Genome Atlas	Lung Adenocarcinoma	UBA7	0.03	0.04	enet	9	0.02	1.8e-03	-5.6	5.6	2.0e-08	0.67	0.07	0.92	FALSE
26	GTEx	Esophagus Mucosa	FAM212A	0.19	0.26	enet	24	0.27	4.4e-18	-5.5	-5.6	2.2e-08	-0.67	1.00	0.00	FALSE
27	GTEx	Esophagus Muscularis	RNF123	0.15	0.14	enet	17	0.14	1.2e-08	-5.7	-5.6	2.4e-08	-0.67	0.99	0.01	FALSE
39	GTEx	Spleen	RNF123	0.13	0.13	lasso	5	0.10	1.3e-03	-5.6	-5.6	2.4e-08	-0.67	0.16	0.26	FALSE
61	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	UBA7	0.08	0.09	lasso	5	0.09	3.4e-10	-5.7	5.6	2.6e-08	0.66	0.07	0.93	FALSE
38	GTEx	Skin Sun Exposed Lower leg	FAM212A	0.05	0.07	enet	16	0.06	1.1e-05	-5.5	-5.6	2.7e-08	-0.67	0.97	0.02	FALSE
25	GTEx	Esophagus Mucosa	UBA7	0.04	0.07	enet	8	0.05	4.5e-04	-5.6	5.5	2.8e-08	0.65	0.77	0.05	FALSE
19	GTEx	Colon Transverse	UBA7	0.28	0.30	lasso	2	0.30	1.1e-14	-5.5	5.5	2.9e-08	0.67	1.00	0.00	FALSE
12	GTEx	Brain Cerebellum	FAM212A	0.27	0.35	lasso	5	0.34	9.7e-11	-5.5	-5.5	3.2e-08	-0.67	0.99	0.01	FALSE
41	GTEx	Testis	RBM6	0.28	0.14	enet	19	0.17	7.7e-08	-4.9	5.5	3.3e-08	0.51	1.00	0.00	FALSE
60	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	UBA7	0.02	0.02	blup	30	0.02	3.8e-03	-5.6	5.5	3.5e-08	0.68	0.04	0.47	FALSE
22	GTEx	Esophagus Mucosa	RBM6	0.18	0.21	enet	18	0.23	3.0e-15	-5.3	5.5	3.6e-08	0.55	1.00	0.00	FALSE
64	The Cancer Genome Atlas	Brain Lower Grade Glioma	MST1R	0.08	0.07	enet	10	0.09	2.6e-10	-5.3	-5.5	4.1e-08	-0.52	0.14	0.86	FALSE
47	GTEx	Whole Blood	UBA7	0.03	0.04	lasso	2	0.01	1.5e-02	-5.6	5.5	4.8e-08	0.64	0.45	0.09	FALSE
5	GTEx	Artery Coronary	RBM6	0.14	0.14	enet	23	0.15	1.0e-05	-6.0	5.4	6.2e-08	0.61	0.95	0.02	FALSE
34	GTEx	Nerve Tibial	RNF123	0.24	0.16	lasso	5	0.15	1.0e-10	-6.0	-5.4	7.7e-08	-0.66	1.00	0.00	FALSE
17	GTEx	Cells Transformed fibroblasts	RNF123	0.08	0.09	enet	14	0.06	1.7e-05	-5.7	-5.4	7.8e-08	-0.68	0.86	0.12	FALSE
4	GTEx	Adipose Visceral Omentum	RNF123	0.08	0.11	lasso	4	0.07	2.2e-04	-5.5	-5.3	1.1e-07	-0.66	0.71	0.14	FALSE
13	GTEx	Brain Cortex	RNF123	0.23	0.05	enet	33	0.04	2.4e-02	-5.6	-5.3	1.1e-07	-0.50	0.24	0.09	FALSE
49	METSIM	Adipose	MST1	0.06	0.03	lasso	8	0.03	2.0e-05	3.3	5.3	1.1e-07	0.55	0.72	0.16	FALSE
31	GTEx	Lung	RNF123	0.13	0.05	enet	18	0.07	5.8e-06	-5.7	-5.3	1.3e-07	-0.77	0.55	0.39	FALSE
20	GTEx	Esophagus Gastroesophageal Junction	RBM6	0.25	0.29	lasso	23	0.30	2.2e-11	4.2	5.3	1.4e-07	0.58	0.99	0.01	FALSE
56	YFS	Blood	COL7A1	0.01	0.01	bslmm	247	0.01	8.0e-04	4.3	5.2	1.5e-07	0.51	0.02	0.87	FALSE
51	NTR	Blood	QRICH1	0.01	0.00	blup	276	0.01	1.6e-04	4.3	-5.2	1.7e-07	-0.66	0.60	0.17	FALSE
58	The Cancer Genome Atlas	Colon Adenocarcinoma	UBA7	0.11	0.06	enet	5	0.05	7.6e-04	-5.6	5.2	1.8e-07	0.50	0.06	0.94	FALSE
14	GTEx	Brain Frontal Cortex BA9	RBM6	0.18	0.25	lasso	3	0.20	5.2e-06	-5.3	-5.2	2.4e-07	-0.52	0.88	0.02	FALSE
6	GTEx	Artery Tibial	RNF123	0.08	0.08	enet	12	0.09	2.5e-07	-5.5	-5.2	2.5e-07	-0.68	0.98	0.02	FALSE
32	GTEx	Lung	GPX1	0.04	0.02	enet	13	0.04	5.7e-04	7.0	-5.2	2.5e-07	-0.86	0.06	0.75	FALSE
3	GTEx	Adipose Visceral Omentum	RBM6	0.20	0.28	enet	30	0.30	6.4e-16	4.4	5.2	2.6e-07	0.56	1.00	0.00	FALSE
28	GTEx	Esophagus Muscularis	NICN1-AS1	0.09	0.04	enet	14	0.06	2.3e-04	6.9	5.1	3.0e-07	0.84	0.07	0.87	FALSE