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chr7:90,874,777-93,160,671

Best TWAS P=6.1e-27 · Best GWAS P=6.66e-56 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CDK6	0.12	0.10	lasso	2	0.10	1.9e-12	7.9	7.9	3.9e-15	0.21	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	CYP51A1	0.05	0.08	lasso	5	0.06	2.4e-08	6.0	-5.9	4.4e-09	-0.05	1.00	0.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	KRIT1	0.04	0.01	blup	318	0.02	1.2e-03	6.1	-7.8	7.7e-15	-0.06	0.60	0.01	TRUE
4	GTEx	Adipose Subcutaneous	GATAD1	0.21	0.14	enet	10	0.16	3.4e-13	8.0	-6.0	2.7e-09	0.05	1.00	0.00	FALSE
5	GTEx	Adipose Visceral Omentum	GATAD1	0.12	0.08	lasso	5	0.06	7.5e-04	8.0	-9.2	5.7e-20	0.03	0.86	0.01	FALSE
6	GTEx	Adrenal Gland	GATAD1	0.40	0.22	lasso	7	0.25	2.0e-09	8.0	-9.7	3.4e-22	0.00	0.72	0.02	FALSE
7	GTEx	Artery Aorta	KRIT1	0.15	0.00	enet	24	0.03	1.3e-02	-3.6	-10.5	1.2e-25	0.18	0.06	0.55	TRUE
8	GTEx	Artery Aorta	GATAD1	0.09	0.08	enet	4	0.07	7.4e-05	8.0	-8.8	8.4e-19	0.01	0.53	0.03	FALSE
9	GTEx	Artery Aorta	AC000120.7	0.06	0.09	lasso	4	0.08	3.4e-05	6.1	-6.2	6.7e-10	-0.04	0.93	0.00	FALSE
10	GTEx	Artery Coronary	GATAD1	0.12	0.15	lasso	3	0.12	8.0e-05	7.7	-8.0	1.8e-15	0.04	0.22	0.05	FALSE
11	GTEx	Artery Coronary	AC000120.7	0.07	0.04	lasso	4	0.02	6.8e-02	5.8	-5.9	4.5e-09	-0.06	0.20	0.04	FALSE
12	GTEx	Artery Tibial	GATAD1	0.14	0.04	enet	17	0.04	4.1e-04	8.0	-5.4	6.8e-08	0.03	0.74	0.06	FALSE
13	GTEx	Artery Tibial	AC000120.7	0.08	0.06	lasso	4	0.06	3.2e-05	5.6	-6.9	5.4e-12	-0.02	0.96	0.00	FALSE
14	GTEx	Brain Caudate basal ganglia	GATAD1	0.21	0.09	lasso	4	0.08	2.3e-03	4.9	-8.8	1.0e-18	0.05	0.10	0.06	FALSE
15	GTEx	Brain Cortex	AC000120.7	0.12	0.08	enet	16	0.07	7.0e-03	6.0	-9.2	3.0e-20	0.01	0.14	0.05	FALSE
16	GTEx	Cells Transformed fibroblasts	GATAD1	0.23	0.20	lasso	4	0.22	1.4e-16	8.0	-7.9	3.3e-15	-0.04	1.00	0.00	FALSE
17	GTEx	Cells Transformed fibroblasts	AC000120.7	0.04	0.05	lasso	4	0.04	5.2e-04	5.7	-6.1	8.0e-10	-0.04	0.82	0.01	FALSE
18	GTEx	Colon Transverse	GATAD1	0.13	0.00	enet	16	0.05	3.0e-03	8.0	-7.4	1.3e-13	0.03	0.22	0.09	FALSE
19	GTEx	Colon Transverse	AC000120.7	0.09	0.04	lasso	5	0.01	9.4e-02	6.2	-6.1	9.0e-10	-0.03	0.23	0.04	FALSE
20	GTEx	Esophagus Gastroesophageal Junction	CDK6	0.21	-0.01	enet	18	0.01	1.6e-01	-9.9	-6.5	5.7e-11	0.17	0.12	0.04	TRUE
21	GTEx	Esophagus Mucosa	AKAP9	0.04	0.03	lasso	15	0.02	2.7e-02	6.1	6.0	2.1e-09	0.04	0.76	0.02	FALSE
22	GTEx	Esophagus Mucosa	GATAD1	0.16	0.05	enet	16	0.08	7.3e-06	8.0	-8.4	3.6e-17	0.03	0.86	0.01	FALSE
23	GTEx	Esophagus Muscularis	GATAD1	0.18	0.10	enet	33	0.13	1.6e-08	8.0	-6.8	1.4e-11	0.05	0.98	0.00	FALSE
24	GTEx	Esophagus Muscularis	FAM133B	0.07	0.01	enet	2	0.01	1.2e-01	-4.0	-5.7	1.6e-08	-0.10	0.10	0.04	TRUE
25	GTEx	Lung	GATAD1	0.15	0.12	lasso	2	0.11	1.1e-08	8.0	-7.9	2.9e-15	0.03	0.99	0.00	FALSE
26	GTEx	Lung	AC000120.7	0.04	0.03	lasso	3	0.01	4.8e-02	6.2	-6.3	3.9e-10	-0.04	0.46	0.02	FALSE
27	GTEx	Muscle Skeletal	CYP51A1	0.10	0.18	enet	21	0.17	5.0e-16	6.1	-6.5	8.5e-11	-0.04	1.00	0.00	FALSE
28	GTEx	Muscle Skeletal	PEX1	0.06	0.03	lasso	5	0.02	2.7e-03	5.3	5.4	6.6e-08	0.00	0.61	0.01	TRUE
29	GTEx	Muscle Skeletal	GATAD1	0.05	0.00	enet	13	0.01	2.4e-02	4.8	-7.2	6.2e-13	0.08	0.48	0.02	FALSE
30	GTEx	Nerve Tibial	AKAP9	0.03	0.05	lasso	2	0.03	2.7e-03	6.1	6.1	1.1e-09	0.03	0.45	0.04	FALSE
31	GTEx	Nerve Tibial	GATAD1	0.30	0.19	lasso	5	0.23	1.8e-16	8.0	-6.5	7.2e-11	0.05	1.00	0.00	FALSE
32	GTEx	Pancreas	AC000120.7	0.05	0.03	enet	12	0.02	4.4e-02	6.5	-6.2	7.9e-10	-0.07	0.30	0.03	FALSE
33	GTEx	Prostate	AC000120.7	0.13	0.09	lasso	3	0.09	2.8e-03	6.1	-6.0	1.6e-09	-0.04	0.13	0.07	FALSE
34	GTEx	Skin Not Sun Exposed Suprapubic	GATAD1	0.22	0.27	lasso	4	0.26	1.1e-14	8.0	-7.8	4.9e-15	0.03	1.00	0.00	FALSE
35	GTEx	Skin Not Sun Exposed Suprapubic	AC000120.7	0.09	0.02	enet	38	0.07	8.3e-05	6.4	-6.0	1.6e-09	0.10	0.24	0.03	FALSE
36	GTEx	Skin Sun Exposed Lower leg	PEX1	0.18	0.06	enet	41	0.03	1.5e-03	-4.2	-6.3	2.6e-10	-0.13	0.24	0.03	FALSE
37	GTEx	Skin Sun Exposed Lower leg	GATAD1	0.30	0.10	enet	14	0.16	7.0e-13	8.0	-8.6	5.5e-18	0.08	1.00	0.00	FALSE
38	GTEx	Skin Sun Exposed Lower leg	AC000120.7	0.06	0.00	enet	24	0.00	7.9e-01	2.3	-5.9	3.3e-09	-0.02	0.15	0.04	FALSE
39	GTEx	Spleen	AC000120.7	0.10	0.07	lasso	5	0.04	3.9e-02	6.2	-5.4	5.7e-08	-0.05	0.15	0.05	FALSE
40	GTEx	Stomach	GATAD1	0.30	0.13	lasso	5	0.15	8.6e-08	8.0	-9.1	7.5e-20	0.03	0.98	0.00	FALSE
41	GTEx	Testis	CDK6	0.10	0.10	lasso	3	0.09	8.0e-05	5.8	-7.0	2.5e-12	-0.20	0.59	0.03	FALSE
42	GTEx	Thyroid	GATAD1	0.18	0.06	lasso	4	0.06	3.3e-05	8.0	-9.0	3.2e-19	0.02	0.97	0.00	FALSE
43	GTEx	Thyroid	AC000120.7	0.04	0.01	lasso	6	0.02	2.2e-02	5.5	-6.2	4.2e-10	-0.03	0.33	0.03	FALSE
44	METSIM	Adipose	GATAD1	0.10	0.05	lasso	7	0.06	9.4e-10	4.8	-7.0	2.2e-12	0.07	1.00	0.00	FALSE
45	ROSMAP	Brain Pre-frontal Cortex	CYP51A1	0.04	0.02	blup	287	0.03	4.7e-05	5.8	-6.6	5.5e-11	-0.04	0.95	0.00	FALSE
46	ROSMAP	Brain Pre-frontal Cortex	AKAP9	0.04	0.00	blup	344	0.01	8.6e-03	-3.8	-6.9	5.2e-12	0.00	0.32	0.02	TRUE
47	ROSMAP	Brain Pre-frontal Cortex	GATAD1	0.17	0.15	lasso	4	0.16	6.0e-20	6.6	-7.9	2.6e-15	0.03	1.00	0.00	FALSE
48	YFS	Blood	CYP51A1	0.03	0.06	blup	288	0.05	1.2e-16	6.0	-5.7	1.3e-08	-0.08	1.00	0.00	FALSE
49	YFS	Blood	GATAD1	0.01	0.01	blup	297	0.01	5.1e-04	8.0	-10.7	6.1e-27	0.08	0.81	0.00	TRUE
50	The Cancer Genome Atlas	Breast Invasive Carcinoma	CYP51A1	0.01	0.02	blup	51	0.02	2.0e-04	6.2	-5.8	7.5e-09	-0.04	0.04	0.94	FALSE
51	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CYP51A1	0.04	0.05	blup	51	0.05	9.4e-07	6.0	-6.1	1.1e-09	-0.04	0.04	0.96	FALSE
52	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GATAD1	0.04	0.04	lasso	2	0.03	2.8e-04	6.5	-6.4	1.7e-10	0.04	0.10	0.42	FALSE
53	The Cancer Genome Atlas	Brain Lower Grade Glioma	CYP51A1	0.01	0.01	blup	51	0.01	1.2e-02	6.2	-5.8	6.2e-09	-0.04	0.03	0.71	FALSE
54	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	LOC401387	0.04	0.00	lasso	1	0.00	1.6e-01	6.2	6.2	4.3e-10	0.06	0.02	0.76	FALSE