Hub : Genes

GFI1B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 YFS Blood 0.0244 0.0117 1.4e-02 0.026 0.004 0.024 0.018 0.023 6.0e-09 1.3e-02 1.6e-08 7.5e-07 2.7e-08
2 TCGA Brain Lower Grade Glioma 0.1638 0.0464 9.9e-07 0.109 0.061 0.109 NA 0.102 2.4e-12 1.7e-07 2.4e-12 NA 1.2e-11

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 2.8 4.4 7.3 1.2 -2.7
Bipolar Disorder or Schizophrenia 1.3 3.2 4.8 1.2 -2.2
Depressed Affect (Nagel 2018) 0.0 0.0 0.0 -0.0 0.1
Depression (Nagel 2018) 0.1 0.2 0.2 -0.5 0.3
Intelligence (Savage-Jansen 2018) 0.5 1.6 2.7 0.7 1.6
Neuroticism (Nagel 2018) 0.0 0.1 0.1 -0.2 0.3
Schizophrenia (2018) 0.5 1.0 1.5 0.7 -1.2
Schizophrenia vs Biploar Disorder 1.1 1.4 2.9 1.7 0.0
Worry (Nagel 2018) 0.1 0.1 0.1 -0.3 0.4
Alzheimer’s Disease (in mother) 0.1 0.1 0.1 0.0 0.3
Alzheimer’s Disease (in father) 1.1 1.2 2.4 -1.6 0.1
Alzheimer’s Disease (including proxy) 0.3 0.4 0.5 -0.7 -0.5
Crohns Disease (2017) 1.5 3.3 3.7 -1.9 1.7
Irritable Bowel Disease (IBD) 0.6 1.5 1.8 -1.0 1.4
Ulcerative Colitis (UC) 0.1 0.2 0.3 0.3 0.5
Major Depression (MDD) 0.1 0.2 0.3 -0.6 0.0
Reaction Time 0.2 0.4 0.7 -0.1 0.9
Verbal and Numeric Reasoning (VNR) 0.4 0.9 1.2 1.1 -0.7
Breast Cancer 1.4 3.3 4.6 -2.2 -1.4
Ovarian Cancer 0.1 0.1 0.2 -0.5 -0.0
Prostate Cancer 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.6 0.8 1.5 -0.3 1.2
Bipolar Disorder (2011) 1.3 1.2 2.4 -1.6 0.0
Body Mass Index (BMI) (2010) 0.4 0.5 0.9 -0.9 -0.5
Coronary Artery Disease (CAD) 0.1 0.1 0.2 -0.4 0.0
Crohns Disease (2012) 1.2 2.0 2.4 -1.5 1.2
Mean Putamen Volume 1.1 1.3 2.0 1.4 -0.8
Fasting Glucose 0.1 0.1 0.1 0.3 0.3
HbA1C 2.1 2.4 4.6 -2.2 0.3
HDL Cholesterol 0.6 1.0 1.2 0.9 -1.1
LDL Cholesterol 0.2 0.4 0.7 0.8 0.3
Lupus 0.0 0.0 0.0 0.2 0.1
Neuroticism (2016) 0.2 0.3 0.5 -0.1 -0.7
Primary Biliary Cirrhosis 1.8 2.5 3.3 1.3 1.8
Rheumatoid Arthritis 1.6 2.2 3.1 1.1 1.8
Schizophrenia (2014) 0.4 0.9 1.5 1.2 -0.6
Triglycerides 0.4 0.6 1.0 -1.0 0.5
Type 2 Diabetes (T2D) (2012) 1.6 1.8 3.6 -1.9 0.0
Ulcerative Colitis 0.3 0.5 1.0 1.0 0.0
Blood Eosinophil Count 5.8 44.6 52.6 -7.2 -6.0
Blood Platelet Count 1.5 17.7 29.5 -2.4 -5.4
Blood Red Count 4.4 43.0 85.9 -9.3 0.1
Blood White Count 0.8 6.0 7.8 -2.8 -2.1
Heel T-Score 0.6 4.8 7.6 -2.8 1.4
BMI 0.1 0.7 1.3 -0.1 -1.1
Height 0.1 1.3 1.4 -1.2 1.0
Waist Hip Ratio (WHR) 0.1 0.2 0.3 -0.5 -0.4
Systolic Blood Pressure 0.8 4.2 5.0 -1.9 2.2
Smoking Status 0.6 1.4 2.3 1.5 0.7
Allergy or Eczema 0.5 1.3 1.6 -1.2 1.0
Cardiovascular Disease 0.1 0.5 1.0 1.0 -0.0
Hypothyroidism (self reported) 0.5 1.2 2.4 -0.2 -1.6
Respiratory disease 0.5 1.1 1.8 -0.7 -1.3
Type 2 Diabetes (T2D) (2018) 0.0 0.0 0.1 -0.1 0.2
Lung FEV1/FVC ratio 0.0 0.2 0.4 -0.2 0.6
Lung FVC 0.2 0.9 1.8 -0.0 1.4
Neuroticism 0.0 0.1 0.1 -0.3 0.2
Chronotype (morning person) 0.3 0.6 0.9 -0.5 -1.0
Hair Pigment 0.0 0.9 1.8 -0.3 -1.3
Tanning 0.0 0.2 0.3 -0.2 0.5
Hand grip strength (left) 0.7 1.8 3.2 -1.8 0.6
Number of treatments/medications taken 0.5 0.9 1.7 -0.1 -1.3
Average weekly spirits intake 1.1 1.3 2.3 -1.5 -0.6
Sensitivity / hurt feelings 0.2 0.3 0.5 0.7 0.0
Frequency of depressed mood in last 2 weeks 0.7 1.0 2.1 -1.4 -0.0
Hearing difficulty/problems: Yes 1.0 1.5 2.4 0.7 1.6
Relative age of first facial hair 0.5 1.0 1.9 -1.4 0.0
Other serious medical condition/disability diagnosed by doctor 0.1 0.1 0.1 0.3 -0.2
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.4 -0.3 0.6
Ever had hysterectomy (womb removed) 0.0 0.0 0.0 -0.0 0.0
Systolic blood pressure, automated reading 0.9 2.6 4.6 -0.7 2.2
Eye problems/disorders: Diabetes related eye disease 1.8 2.0 2.2 -1.5 -1.4
Angina 0.8 1.0 1.1 1.1 -1.0
Medication for hormone replacement therapy 1.4 1.5 2.0 1.0 1.4
Vitamin and mineral supplements 0.7 0.9 1.3 1.1 -0.8
Supplements: Zinc 2.0 2.2 4.3 2.1 -0.2
Medication: Co-codamol 0.6 0.7 1.3 -0.4 -1.1
Medication: Metformin 0.8 1.1 1.6 1.3 -0.8
Diabetes (father) 0.9 1.1 1.9 0.5 -1.4
Diabetes (mother) 2.3 2.9 3.6 -1.9 1.5
Severe depression (siblings) 1.2 1.3 2.4 -1.5 -0.5
Pack years adult smoking proportion 0.4 0.6 1.2 -0.2 1.1
Impedance of leg (right) 0.4 2.0 2.1 -1.4 1.4
Leg fat-free mass (left) 0.2 1.0 1.6 1.3 -0.6
Trunk fat percentage 0.1 0.6 0.8 0.9 -0.6
Hand grip strength (right) 1.1 3.0 5.9 -2.4 0.5
Townsend deprivation index at recruitment 0.0 0.0 0.1 -0.3 0.0
Current tobacco smoking 0.1 0.2 0.4 0.6 -0.0
Average weekly fortified wine intake 0.4 0.5 0.9 -1.0 -0.2
Maternal smoking around birth 0.5 0.7 1.0 1.0 -0.6
Fed-up feelings 0.2 0.3 0.3 -0.6 -0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.2 -0.5 -0.1
Relative age voice broke 1.1 1.7 2.8 -0.8 -1.7
Taking other prescription medications 0.7 1.1 1.9 -1.4 -0.5
Age when periods started (menarche) 1.0 2.5 3.7 1.9 -1.1
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.2 -0.5 0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 1.3 -1.1 -0.4
Tinnitus: Yes, but not now, but have in the past 1.1 1.2 2.4 0.1 -1.5
Qualifications: CSEs or equivalent 0.5 0.7 0.7 0.8 0.8
Serious illness, injury or assault to yourself 1.1 1.3 1.3 -1.1 1.1
High blood pressure 0.0 0.1 0.1 0.3 -0.3
Hayfever, allergic rhinitis or eczema 0.6 1.3 2.5 -0.2 1.6
Multivitamins +/- minerals 0.1 0.2 0.4 -0.6 0.1
Stomach or abdominal pain in last month 0.3 0.4 0.7 0.0 0.8
Supplements: Glucosamine 0.6 0.8 1.7 -1.3 0.1
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 1.7 -1.3 0.9
Medication: Atenolol 1.7 2.1 2.3 1.5 -1.4
Medication: Levothyroxine sodium 0.1 0.1 0.1 0.2 0.4
Sitting height 0.1 1.1 2.1 -1.4 0.0
Chronic bronchitis/emphysema (father) 0.6 0.7 1.1 -0.5 -1.0
High blood pressure (mother) 1.3 1.8 3.3 0.6 -1.8
Body mass index (BMI) 0.3 1.3 2.1 0.7 -1.4
Impedance of leg (left) 0.4 2.0 3.4 -1.8 0.8
Leg predicted mass (left) 0.2 0.9 1.5 1.2 -0.5
Trunk fat mass 0.1 0.6 0.6 0.8 -0.7
Waist circumference 0.3 1.2 1.4 1.0 -1.2
Number of incorrect matches in round 1.3 2.1 2.5 -1.6 1.3
Past tobacco smoking 0.4 0.7 0.9 -0.9 0.7
Alcohol usually taken with meals 0.1 0.1 0.2 -0.1 0.4
Nervous feelings 0.1 0.1 0.2 -0.5 -0.3
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.1 0.2 -0.5 0.1
Hearing difficulty/problems with background noise 1.8 2.9 5.9 -0.1 2.4
Hair/balding pattern: Pattern 2 0.6 0.7 1.0 -1.0 -0.7
Had menopause 0.1 0.1 0.2 -0.4 -0.2
Had other major operations 3.5 4.3 5.0 -1.9 -2.2
Forced vital capacity (FVC) 0.3 1.2 2.3 -1.5 0.2
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.9 1.8 -1.4 -0.1
Ever unenthusiastic/disinterested for a whole week 0.4 0.4 0.5 0.7 -0.6
Qualifications: None of the above 0.0 0.0 0.0 0.2 0.1
Financial difficulties in last 2 years 0.2 0.3 0.4 -0.6 -0.5
Mouth/teeth dental problems 0.0 0.0 0.0 0.2 -0.0
Heart attack 1.1 1.4 1.4 1.1 -1.2
Allergy 0.6 1.4 2.6 0.3 -1.6
Pain all over the body in last month 1.6 1.7 3.0 -1.7 0.7
Diabetes (self-reported) 0.2 0.3 0.4 0.5 0.6
Hayfever/allergic rhinitis (self-reported) 0.5 0.6 1.3 -1.1 -0.1
Medication: Ramipril 0.3 0.4 0.4 0.6 -0.7
Medication: Simvastatin 2.3 3.4 5.8 2.4 -1.0
Fluid intelligence score 0.2 0.3 0.4 0.5 -0.6
Illnesses of siblings 0.6 0.9 1.7 -0.0 1.3
Neuroticism score 0.1 0.2 0.4 -0.6 0.2
Weight 0.3 1.3 2.1 0.6 -1.5
Impedance of arm (right) 0.2 0.9 1.4 1.2 0.7
Arm fat percentage (right) 0.3 1.1 1.4 1.2 -0.9
Trunk fat-free mass 0.0 0.1 0.2 0.1 -0.5
Hip circumference 0.2 0.7 0.9 1.0 -0.7
Time employed in main current job 0.6 0.7 1.5 1.2 0.1
Alcohol intake versus 10 years previously 1.0 1.6 1.6 -1.2 -1.3
Father’s age at death 0.0 0.0 0.0 -0.1 0.0
Worrier / anxious feelings 0.2 0.5 0.9 -0.9 0.2
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.2 -0.4 0.2
Falls in the last year 0.6 0.8 1.0 0.8 1.0
Hair/balding pattern: Pattern 3 0.7 1.1 2.2 0.1 1.5
Number of live births 1.7 2.4 3.6 -1.9 -1.1
Forced expiratory volume in 1-second (FEV1) 0.2 0.7 1.5 -1.2 0.2
Pulse rate 0.3 0.5 1.0 -1.0 0.0
Happiness 0.3 0.4 0.6 0.4 -0.8
Noisy workplace 0.3 0.4 0.7 0.2 0.9
Qualifications: A levels/AS levels or equivalent 0.0 0.0 0.1 0.3 -0.0
Serious illness, injury or assault of a close relative in last 2 years 2.0 2.3 4.6 -2.1 -0.0
Mouth/teeth dental problems: Dentures 0.7 1.1 1.1 1.1 -1.1
Asthma 0.8 1.5 1.8 -1.1 -1.4
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.7 1.2 0.5 -1.1
Medication: Cholesterol lowering 1.2 1.9 2.6 1.6 -1.1
Depression (self-reported) 0.1 0.1 0.2 0.1 -0.4
Medication: Lansoprazole 0.4 0.4 0.8 -0.9 0.2
Prospective memory result 1.1 1.4 1.9 -0.9 -1.4
Lung cancer (father) 2.0 2.3 4.4 0.5 2.1
Illnesses of mother 0.2 0.2 0.3 0.5 0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.6 0.9 -0.9 0.5
Pulse wave Arterial Stiffness index 0.1 0.1 0.1 0.4 -0.3
Impedance of arm (left) 0.1 0.6 1.1 1.1 0.3
Arm fat mass (right) 0.2 0.9 1.4 0.6 -1.2
Trunk predicted mass 0.0 0.1 0.3 0.1 -0.5
Standing height 0.0 0.1 0.1 -0.3 -0.3
Length of working week for main job 0.2 0.2 0.4 0.1 0.6
Exposure to tobacco smoke at home 0.5 0.5 1.0 -0.3 -1.0
Breastfed as a baby 0.4 0.5 1.0 1.0 -0.1
Tense / ‘highly strung’ 1.3 2.1 4.0 -2.0 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 1.2 1.8 2.3 -1.1 -1.5
Hair/balding pattern: Pattern 4 0.1 0.2 0.4 0.6 -0.2
Birth weight of first child 1.3 2.3 3.9 0.8 -2.0
Peak expiratory flow (PEF) 0.2 0.5 0.9 -0.9 -0.4
Pulse wave reflection index 0.3 0.3 0.7 0.2 0.8
Ever highly irritable/argumentative for 2 days 0.1 0.2 0.3 0.3 0.5
Loud music exposure frequency 2.1 2.3 4.7 2.2 0.1
Qualifications: O levels/GCSEs or equivalent 0.9 1.4 2.7 1.6 -0.3
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 0.7 -0.9 0.3
Blood clot in the leg (DVT) 1.6 2.1 3.8 0.6 1.9
Medication: Paracetamol 1.0 1.7 3.0 -1.7 -0.7
Headache pain in last month 0.0 0.0 0.0 -0.0 0.2
Medication for cholesterol, blood pressure or diabetes 1.3 2.2 3.7 -0.8 1.9
Glaucoma (self-reported) 0.7 0.8 1.6 -0.1 1.3
Gout (self-reported) 1.9 2.6 5.2 0.1 2.3
Hypothyroidism/myxoedema (self-reported) 0.3 0.5 1.1 0.0 -1.0
Medication: Amlodipine 0.5 0.6 0.7 0.8 -0.8
Medication: Ventolin 100micrograms inhaler 0.7 0.8 1.0 1.0 -0.8
Birth weight 0.8 1.8 3.0 1.7 -0.8
Chronic bronchitis/emphysema (mother) 0.5 0.6 0.9 0.6 -1.0
High blood pressure (siblings) 0.4 0.6 1.0 -0.4 -1.0
Forced vital capacity (FVC), Best measure 0.2 0.8 1.5 -1.2 0.4
Body fat percentage 0.1 0.4 0.4 0.7 -0.7
Leg fat percentage (right) 0.1 0.2 0.4 0.2 -0.7
Arm fat-free mass (right) 0.0 0.2 0.2 -0.5 -0.3
Exposure to tobacco smoke outside home 2.9 3.8 7.6 -2.8 -0.3
Comparative body size at age 10 0.8 2.1 4.1 2.0 -0.1
Number of full brothers 0.6 0.8 1.2 1.1 0.6
Worry too long after embarrassment 0.4 0.7 0.7 -0.8 0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.4 0.3 0.7
Wheeze or whistling in the chest in last year 0.7 1.2 1.3 1.1 -1.1
Number of children fathered 0.8 0.9 1.1 1.1 -0.8
Reason for reducing amount of alcohol drunk: Health precaution 1.1 1.3 2.1 -1.5 0.7
Age at first live birth 0.5 0.9 1.3 -1.1 -0.7
Pulse wave peak to peak time 0.0 0.0 0.0 -0.2 0.2
Health satisfaction 0.2 0.3 0.4 -0.6 -0.3
Shortness of breath walking on level ground 0.3 0.4 0.6 -0.8 -0.4
Qualifications: College or University degree 0.0 0.2 0.3 0.2 -0.5
Eye problems/disorders: None of the above 1.4 1.7 2.6 1.6 -0.9
Mouth/teeth dental problems: Loose teeth 1.6 1.9 2.8 1.0 -1.7
Emphysema/chronic bronchitis 3.3 3.7 6.2 2.5 -1.1
Medication for pain relief, constipation, heartburn 0.3 0.5 0.6 0.8 0.6
Neck or shoulder pain in last month 0.9 1.3 1.3 1.2 -1.1
Medication: Blood pressure 0.4 0.8 1.2 0.6 -1.1
Angina (self-reported) 0.4 0.5 0.9 0.9 -0.4
Migraine (self-reported) 1.2 1.5 2.3 -1.5 0.8
Medication: Ibuprofen 1.0 1.2 1.4 1.0 -1.2
Medication: Allopurinol 1.8 2.4 4.8 -0.4 2.2
Medication: Omeprazole 0.3 0.3 0.7 0.8 -0.1
Medication: Seretide 50 evohaler 0.7 0.8 1.4 0.3 -1.2
Mean time to correctly identify matches 0.0 0.0 0.1 -0.2 0.2
Heart disease (mother) 0.0 0.0 0.0 0.0 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 4.1 4.9 5.4 -2.1 2.3
Whole body fat mass 0.2 0.8 1.3 0.6 -1.1
Leg fat mass (right) 0.2 0.7 1.4 0.3 -1.2
Arm predicted mass (right) 0.1 0.5 0.6 -0.8 -0.6
Pulse rate, automated reading 0.1 0.5 0.9 -0.9 -0.2
Alcohol intake frequency. 0.6 1.3 1.5 -1.2 -1.1
Comparative height size at age 10 0.2 1.1 1.9 0.6 -1.4
Number of full sisters 0.6 0.8 0.8 -0.9 -0.9
Suffer from ‘nerves’ 0.1 0.2 0.3 -0.0 0.6
Overall health rating 0.6 1.2 1.5 -1.0 -1.2
Chest pain or discomfort 0.4 0.6 1.1 -1.1 0.4
Had major operations 0.3 0.4 0.8 0.9 0.1
Age at last live birth 0.9 1.2 1.4 -1.2 -1.1
Family relationship satisfaction 2.7 3.4 4.4 2.1 1.5
Leg pain on walking 0.4 0.5 0.8 0.5 -0.9
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.8 1.3 -1.2 0.5
Commuting to job workplace: Car/motor vehicle 0.0 0.0 0.0 -0.1 0.1
Illness, injury, bereavement, stress in last 2 years 2.3 2.8 4.6 1.0 -2.1
Medication: Aspirin 0.2 0.2 0.3 -0.3 0.6
Supplements: Vitamin C 0.1 0.2 0.2 -0.4 -0.4
Knee pain experienced in last month 0.7 1.1 2.1 1.4 -0.5
Hypertension (Self-reported) 0.0 0.1 0.3 0.5 0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.0 0.1 0.1 -0.3 -0.1
Illnesses of father: Heart disease 0.0 0.0 0.0 0.1 0.1
Illnesses of siblings: Diabetes 0.8 1.0 1.9 -1.4 -0.3
Smoking status: Previous 0.3 0.4 0.7 0.8 -0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.0 0.0 0.1 0.1 0.3
Whole body fat-free mass 0.0 0.3 0.3 0.5 -0.5
Leg fat-free mass (right) 0.2 1.0 1.3 1.1 -0.8
Arm fat percentage (left) 0.3 1.3 1.9 1.4 -0.8
Average weekly red wine intake 2.6 3.8 7.6 2.7 0.4
Handedness (chirality/laterality): Left-handed 2.0 2.4 4.7 2.2 -0.1
Mood swings 0.3 0.6 0.6 -0.7 -0.8
Loneliness, isolation 0.2 0.3 0.4 -0.6 0.4
Long-standing illness, disability or infirmity 1.2 1.9 3.3 -0.7 -1.8
Ever had bowel cancer screening 0.2 0.2 0.4 0.7 -0.1
Diabetes diagnosed by doctor 0.3 0.4 0.8 0.9 0.3
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.2 1.4 -1.2 -1.0
Friendships satisfaction 0.9 1.1 2.2 1.5 -0.2
Qualifications: nursing, teaching 0.7 1.1 2.1 0.4 -1.4
Commuting to job workplace: Walk 0.0 0.0 0.0 -0.2 -0.1
Eye problems/disorders: Cataract 1.9 2.1 3.2 -1.8 1.1
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 1.0 -1.0 0.2
Medication for cholesterol 0.3 0.4 0.6 -0.8 0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.5 1.7 2.8 -1.7 -0.8
Back pain experienced in last month 6.3 9.2 14.9 -1.9 -3.9
Mineral and other dietary supplements 1.1 1.5 2.7 1.6 0.5
Breast cancer (self-reported) 0.4 0.5 0.7 -0.5 -0.9
Asthma (self-reported) 0.8 1.7 2.2 -1.1 -1.5
Osteoporosis (self-reported) 2.0 2.4 4.7 -2.2 -0.3
Osteoarthritis (self-reported) 0.1 0.1 0.1 -0.4 -0.1
Medication: Aspirin 0.1 0.1 0.3 0.0 0.5
Medication: Gliclazide 0.2 0.3 0.5 0.7 0.1
Illnesses of father: None of the above (group 1) 0.0 0.1 0.1 -0.2 0.3
Smoking status: Current 0.2 0.2 0.5 0.7 -0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.7 1.4 0.0 1.2
Whole body water mass 0.0 0.2 0.4 0.3 -0.6
Leg predicted mass (right) 0.2 1.0 1.3 1.1 -0.8
Arm fat mass (left) 0.2 0.8 1.0 0.8 -1.0
Number of self-reported non-cancer illnesses 0.3 0.6 0.8 -0.9 -0.6
Average weekly champagne plus white wine intake 1.7 2.3 4.6 0.0 2.1
Miserableness 0.6 1.0 1.7 -1.3 -0.6
Guilty feelings 0.2 0.3 0.5 0.3 0.7
Wears glasses or contact lenses 0.4 0.4 0.6 0.8 -0.5
Ever taken oral contraceptive pill 0.2 0.2 0.2 -0.4 0.5
Hearing aid user 0.9 1.0 1.9 1.4 -0.3
Mother’s age at death 0.8 1.0 1.4 -1.2 0.8
Financial situation satisfaction 1.3 1.6 3.1 -0.0 -1.8
Tinnitus: Yes, now most or all of the time 0.8 0.9 1.3 1.1 0.8
Commuting to job workplace: Public transport 0.5 0.6 1.1 1.0 0.4
Eye problems/disorders: Glaucoma 0.6 0.7 0.8 -0.8 0.9
Medication: Blood pressure 0.2 0.4 0.4 0.6 -0.6
Pain type(s) experienced in last month: Hip pain 0.5 0.7 0.8 -0.9 -0.7
Supplements: Fish oil (including cod liver oil) 0.8 1.1 1.9 -1.4 -0.5
High cholesterol (Self-reported) 0.6 1.1 2.3 1.5 0.1
Medication: Bendroflumethiazide 0.4 0.7 1.3 0.0 -1.1
Medication: Paracetamol 0.5 0.8 1.1 -1.0 -0.8
Medication: Lisinopril 1.1 1.4 2.7 0.3 -1.6
Medication: Atorvastatin 0.6 0.8 1.3 -0.5 -1.1
Illnesses of father: High blood pressure 0.4 0.5 0.9 0.9 -0.5
Alcohol drinker status: Never 0.1 0.1 0.1 0.3 -0.2
Ever smoked 0.3 0.6 0.8 -0.6 -0.9
Basal metabolic rate 0.1 0.4 0.6 0.5 -0.8
Leg fat percentage (left) 0.1 0.5 0.9 0.1 -1.0
Arm fat-free mass (left) 0.1 0.3 0.4 -0.5 -0.6
Number of operations (self-reported) 0.5 0.8 1.5 -0.1 -1.2
Average weekly beer plus cider intake 1.5 2.1 4.2 0.4 -2.0
Irritability 0.0 0.1 0.1 -0.1 0.3
Risk taking 0.5 0.7 1.4 -0.2 1.2
Ever had prostate specific antigen (PSA) test 0.6 0.7 1.0 0.7 1.0
Fractured/broken bones in last 5 years 1.4 1.9 1.9 1.4 -1.4
Age started oral contraceptive pill 0.8 1.0 1.0 -1.0 -1.0
Diastolic blood pressure, automated reading 0.5 1.5 2.9 -0.3 1.7
Ever depressed for a whole week 1.1 1.4 1.8 1.0 -1.3
Unable to work because of sickness or disability 0.1 0.1 0.2 -0.4 -0.4
Commuting to job workplace: Cycle 0.4 0.5 1.0 -1.0 -0.0
Myopia 0.5 0.7 1.5 1.2 -0.0
Vascular/heart problems diagnosed by doctor 0.1 0.2 0.4 -0.2 0.6
Cholesterol lowering medication 0.4 0.5 0.7 0.5 -0.9
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 0.7 0.9 -0.7
Pain experienced in last month 0.5 0.9 1.6 0.4 1.3
Supplements: Calcium 1.9 2.1 4.2 0.1 -2.1
Basal cell carcinoma (self-reported) 0.0 0.0 0.0 0.0 -0.1
Heart attack/myocardial infarction (self-reported) 1.0 1.3 1.5 1.0 -1.2
Deep venous thrombosis (DVT) (self-reported) 1.6 2.0 2.9 1.1 1.7
Heart disease (siblings) 2.4 2.9 4.6 1.1 -2.1
Alcohol drinker status: Previous 1.8 2.1 4.1 -2.0 -0.3
Pack years of smoking 0.3 0.4 0.7 0.1 0.9
Impedance of whole body 0.1 0.5 0.6 -0.7 0.8
Leg fat mass (left) 0.2 0.9 1.7 0.2 -1.3
Arm predicted mass (left) 0.0 0.2 0.3 -0.4 -0.5