TWAS hub - GBGT1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Lung	0.1709	0.0595	0.0020	0.017	NA	0.010	NA	0.019	0.018	NA	0.053	NA	0.012
2	METSIM	Adipose	0.0439	0.0220	0.0240	-0.001	0.005	0.005	0.001	0.001	0.550	0.0480	0.055	0.24	0.260
3	TCGA	Lung Adenocarcinoma	0.0547	0.0283	0.0094	0.009	0.017	0.003	NA	0.005	0.026	0.0038	0.120	NA	0.069

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Blood clot in the leg (DVT)	7.6	9.8	12.5	-3.5	-3.5	-2.2
Deep venous thrombosis (DVT) (self-reported)	7.0	9.0	12.8	-3.3	-3.6	-1.8
Medication: Atorvastatin	4.7	5.8	8.9	-3.0	-2.6	1.3
Illnesses of siblings: Diabetes	4.0	5.0	10.0	-1.6	-1.6	3.2
Primary Biliary Cirrhosis	3.9	5.5	12.9	3.6	1.7	-0.8
Blood Red Count	3.7	36.0	75.3	2.2	8.7	-5.3
Age at last live birth	3.3	4.8	8.1	2.8	1.9	-1.7
Blood Platelet Count	3.0	35.3	49.6	-7.0	-4.4	6.1
Glaucoma (self-reported)	2.8	3.4	9.3	0.2	0.8	-3.1
Ever had bowel cancer screening	2.5	2.9	8.0	0.4	0.7	2.8
Eye problems/disorders: Glaucoma	2.5	3.0	8.9	-0.1	0.4	-3.0
Heart disease (mother)	2.4	2.9	7.6	-0.9	-2.8	0.5
Handedness (chirality/laterality): Left-handed	2.4	2.9	8.6	-0.3	-2.9	0.2
Diverticular disease/diverticulitis (self-reported)	2.3	2.7	5.4	2.3	0.4	1.6
Illnesses of siblings	2.3	3.2	6.4	1.0	1.5	-2.5
Serious illness, injury or assault of a close relative in last 2 years	2.3	2.6	6.2	2.5	-1.2	0.3
High cholesterol (Self-reported)	2.3	4.1	10.0	-0.5	-3.2	1.5
Smoking Status	2.2	5.3	14.1	1.0	3.8	-0.9
Qualifications: NVQ or HND or HNC or equivalent	2.1	2.6	6.1	-2.5	-0.5	-1.1
Wears glasses or contact lenses	2.1	2.4	6.5	0.8	-2.5	0.4
Heart disease (siblings)	2.1	2.6	4.5	-2.1	-1.6	0.9
Ever used hormone-replacement therapy (HRT)	2.0	2.6	5.5	-0.4	-1.4	2.3
Lung cancer (father)	2.0	2.3	6.3	0.2	0.8	2.5
Exposure to tobacco smoke at home	2.0	2.3	6.6	0.4	2.6	0.4
Suffer from ‘nerves’	2.0	3.2	4.7	-2.2	-2.0	0.9
Smoking status: Previous	2.0	3.0	7.1	2.7	1.3	-0.1
Supplements: Glucosamine	1.9	2.4	4.9	0.7	1.4	2.2
Alcohol intake versus 10 years previously	1.9	2.9	6.2	0.1	1.6	-2.5
Breastfed as a baby	1.9	2.3	3.5	0.7	-1.7	1.9
Supplements: Zinc	1.8	2.0	4.0	1.3	0.3	-2.0
Loud music exposure frequency	1.8	2.0	3.2	1.7	1.8	0.1
Mother’s age at death	1.8	2.3	3.8	2.0	1.0	-1.4
Long-standing illness, disability or infirmity	1.7	2.5	6.6	0.1	1.0	2.6
HbA1C	1.6	1.8	3.0	-1.2	-1.7	0.9
Blood Eosinophil Count	1.6	12.2	30.8	-0.2	5.5	2.4
Alcohol usually taken with meals	1.6	2.6	4.0	-1.4	-1.4	2.0
Financial difficulties in last 2 years	1.6	2.1	4.5	0.5	2.1	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.4	2.5	-1.6	-1.5	1.6
Smoking status: Current	1.6	2.5	6.8	-0.0	2.6	-0.9
Cholesterol lowering medication	1.6	2.3	3.7	-0.5	-1.9	1.7
Ovarian Cancer	1.5	2.0	4.0	1.2	2.0	-0.8
Coronary Artery Disease (CAD)	1.5	1.8	5.3	0.0	-2.3	0.0
LDL Cholesterol	1.5	2.4	7.2	0.1	-2.7	0.4
Eye problems/disorders: Diabetes related eye disease	1.5	1.6	1.9	-1.4	1.3	-1.1
Past tobacco smoking	1.5	2.8	4.2	-2.0	-2.0	-0.5
Had other major operations	1.5	1.9	4.5	-2.1	1.0	0.4
Pain all over the body in last month	1.5	1.6	2.1	1.4	0.9	-1.5
Father’s age at death	1.5	2.0	4.2	2.1	0.6	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	1.9	5.0	-0.4	-0.8	2.2
Chest pain or discomfort	1.5	2.2	3.4	-1.1	1.9	1.4
Alcohol drinker status: Never	1.5	1.8	3.7	1.1	1.9	-0.8
Reaction Time	1.4	2.7	4.0	1.1	-2.0	-1.6
Mean time to correctly identify matches	1.4	2.7	5.6	1.4	-2.4	-0.7
Tinnitus: Yes, now most or all of the time	1.4	1.6	2.5	1.4	0.5	-1.6
Medication for hormone replacement therapy	1.3	1.4	1.9	-1.4	-1.0	1.2
Hair/balding pattern: Pattern 2	1.3	1.6	2.5	1.1	1.6	-1.1
Osteoarthritis (self-reported)	1.3	1.7	3.6	1.2	-0.0	1.9
Medication: Gliclazide	1.3	1.4	1.9	-1.3	-1.4	-0.8
Schizophrenia (2014)	1.2	2.6	5.2	1.3	-1.0	2.3
Current tobacco smoking	1.2	2.0	5.1	-0.1	2.3	-0.9
Medication: Lansoprazole	1.2	1.4	3.2	-0.6	0.8	1.8
Eye problems/disorders: None of the above	1.2	1.4	2.4	0.6	-1.3	1.5
Had major operations	1.2	1.4	2.9	0.5	1.7	-0.9
Medication: Aspirin	1.2	1.6	2.0	-1.3	-1.4	-1.0
Medication for cholesterol	1.2	1.8	2.9	1.4	0.8	-1.7
Ulcerative Colitis (UC)	1.1	2.1	4.9	-1.2	0.3	2.2
Blood White Count	1.1	8.1	20.0	-0.8	4.5	1.9
Angina	1.1	1.5	3.3	-1.1	1.8	-0.2
Relative age voice broke	1.1	1.7	3.5	-0.5	1.9	-1.2
Mouth/teeth dental problems: Bleeding gums	1.1	1.5	3.2	-1.8	0.4	-1.0
Chronic bronchitis/emphysema (mother)	1.1	1.3	1.9	1.4	0.9	-1.1
Angina (self-reported)	1.1	1.4	3.4	-0.9	1.9	-0.1
Ever taken oral contraceptive pill	1.1	1.3	3.0	-0.6	0.6	1.7
Pack years of smoking	1.1	1.6	4.3	-0.5	2.1	-0.4
Bipolar Disorder or Schizophrenia	1.0	2.4	5.6	0.8	-1.0	2.4
Body Mass Index (BMI) (2010)	1.0	1.4	2.7	-0.9	0.8	1.6
Average weekly spirits intake	1.0	1.2	3.2	-1.8	0.7	-0.0
Diabetes (father)	1.0	1.3	3.7	0.1	-0.3	-1.9
Pack years adult smoking proportion	1.0	1.5	2.9	-1.1	1.7	-0.6
Had menopause	1.0	1.2	2.1	1.1	-1.5	0.7
Falls in the last year	1.0	1.3	2.0	1.4	1.2	-0.7
Number of live births	1.0	1.4	1.7	1.1	1.3	-1.1
Happiness	1.0	1.2	3.3	1.8	-0.6	0.0
Medication: Cholesterol lowering	1.0	1.6	3.0	-1.1	-1.7	-0.7
Peak expiratory flow (PEF)	1.0	2.4	3.7	-0.0	1.9	1.9
Medication: Paracetamol	1.0	1.6	2.2	-1.5	1.4	0.7
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.4	-1.6	0.7	0.9
Worry too long after embarrassment	1.0	1.7	2.7	-0.6	-1.6	1.4
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	1.7	1.2	1.3	0.5
Eye problems/disorders: Cataract	1.0	1.2	3.3	-1.8	-0.1	-0.4
Basal cell carcinoma (self-reported)	1.0	1.1	2.1	-0.0	1.4	1.2
Worrier / anxious feelings	0.9	1.8	4.3	-0.3	-0.9	2.1
Noisy workplace	0.9	1.1	1.6	1.3	1.2	-0.6
Illnesses of mother	0.9	1.1	1.5	-1.2	0.5	-1.2
Exposure to tobacco smoke outside home	0.9	1.2	2.4	-0.9	0.6	-1.5
Wheeze or whistling in the chest in last year	0.9	1.5	3.8	-0.4	2.0	0.8
Age at first live birth	0.9	1.6	2.7	1.3	1.7	-0.7
Friendships satisfaction	0.9	1.1	2.0	1.2	0.0	-1.4
Medication: Aspirin	0.9	1.1	1.7	-1.3	-1.1	-0.6
Guilty feelings	0.9	1.3	3.4	-0.7	-1.8	0.2
Ever smoked	0.9	1.6	4.5	0.4	2.1	0.2
Bipolar Disorder (2018)	0.8	1.3	2.8	1.0	-0.4	1.7
Heel T-Score	0.8	6.2	18.3	-0.0	4.3	0.5
Waist Hip Ratio (WHR)	0.8	3.7	9.0	-1.5	0.1	-3.0
Type 2 Diabetes (T2D) (2018)	0.8	1.5	3.1	-1.8	-1.1	-0.2
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	2.2	-0.9	1.5	0.3
Diabetes (mother)	0.8	1.0	2.6	-1.6	-0.7	-0.2
High blood pressure	0.8	2.3	4.0	1.6	2.0	-0.6
Impedance of leg (left)	0.8	4.0	8.3	-0.4	2.9	-1.9
Pulse wave Arterial Stiffness index	0.8	1.0	1.1	1.1	0.8	1.0
Qualifications: College or University degree	0.8	2.7	4.2	0.8	-1.8	2.1
Migraine (self-reported)	0.8	1.0	1.6	0.5	-1.3	1.1
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.2	-0.9	-0.9	1.1
Illnesses of father: None of the above (group 1)	0.8	0.9	2.0	-0.6	0.7	1.4
Hearing aid user	0.8	1.0	1.2	1.0	0.8	-1.1
Pain type(s) experienced in last month: Hip pain	0.8	1.0	1.3	-0.7	1.1	1.1
Medication: Bendroflumethiazide	0.8	1.2	3.2	1.8	0.1	0.6
Average weekly beer plus cider intake	0.8	1.1	1.8	0.9	1.3	-0.9
Crohns Disease (2017)	0.7	1.6	2.7	-1.6	1.4	0.2
Irritable Bowel Disease (IBD)	0.7	1.7	2.5	-1.3	1.0	1.6
Breast Cancer	0.7	1.6	4.0	0.1	1.0	-2.0
Crohns Disease (2012)	0.7	1.2	2.6	0.0	1.0	1.6
Ulcerative Colitis	0.7	1.0	2.9	-0.1	-0.1	1.7
Sensitivity / hurt feelings	0.7	1.3	2.9	-0.5	0.8	1.7
Medication: Metformin	0.7	0.9	2.8	-0.0	-1.7	0.1
Impedance of leg (right)	0.7	3.2	6.0	-0.1	2.4	-1.9
Qualifications: CSEs or equivalent	0.7	0.9	1.6	-0.9	-0.5	-1.3
Medication: Simvastatin	0.7	1.0	1.3	0.9	-1.2	0.9
Prospective memory result	0.7	0.8	1.9	1.4	-0.6	0.5
Birth weight of first child	0.7	1.2	3.5	0.5	-0.1	1.9
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	2.1	-1.3	-0.4	1.4
Leg fat percentage (right)	0.7	2.6	4.1	1.8	2.0	-0.6
Pulse wave peak to peak time	0.7	0.8	0.9	-0.8	-0.9	-1.0
Emphysema/chronic bronchitis	0.7	0.7	1.6	-1.3	0.2	-0.8
Medication: Blood pressure	0.7	1.2	2.9	0.7	1.7	-0.1
Average weekly red wine intake	0.7	1.1	2.9	-0.4	-1.7	0.4
Loneliness, isolation	0.7	1.0	2.8	-1.7	0.3	0.3
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	2.3	-1.1	0.1	1.5
Number of operations (self-reported)	0.7	1.0	2.2	-1.5	-0.9	0.3
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.7	-0.1	0.8	1.3
Ever depressed for a whole week	0.7	0.9	2.4	-1.6	0.1	0.4
Commuting to job workplace: Cycle	0.7	0.8	2.2	0.5	-1.5	0.0
Vascular/heart problems diagnosed by doctor	0.7	1.8	3.4	-1.1	-1.8	0.9
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.0	-0.1	-1.4	-0.9
Schizophrenia (2018)	0.6	1.3	2.9	-0.0	-1.0	1.7
Worry (Nagel 2018)	0.6	1.3	1.8	-1.1	-1.3	1.0
Age at First Birth	0.6	0.8	2.1	0.3	0.6	-1.4
Neuroticism	0.6	1.4	3.0	-0.6	-0.8	1.7
Chronotype (morning person)	0.6	1.4	2.9	-1.1	0.3	1.7
Number of treatments/medications taken	0.6	1.0	1.3	-0.8	1.1	1.1
Vitamin and mineral supplements	0.6	0.7	1.4	-1.2	-0.7	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.7	1.7	-0.6	1.3	0.4
Taking other prescription medications	0.6	0.9	1.4	-1.2	0.1	1.2
Number of incorrect matches in round	0.6	1.1	2.3	0.9	-0.2	-1.5
Medication: Ramipril	0.6	0.8	1.5	0.1	0.9	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	1.6	1.0	0.7	-1.3
Length of working week for main job	0.6	0.7	1.2	-1.1	-0.4	0.8
Gout (self-reported)	0.6	0.8	2.3	-0.1	-0.1	-1.5
High blood pressure (siblings)	0.6	0.9	2.5	-0.4	-0.3	1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	0.9	0.8	0.8	-0.9
Supplements: Vitamin C	0.6	0.7	1.0	0.9	1.0	0.5
Qualifications: nursing, teaching	0.6	0.9	1.5	0.2	-1.0	1.2
Back pain experienced in last month	0.6	0.9	1.4	1.2	1.1	0.5
Breast cancer (self-reported)	0.6	0.7	1.4	0.6	-1.2	-0.6
Average weekly champagne plus white wine intake	0.6	0.8	1.2	1.1	-0.7	0.9
Medication: Paracetamol	0.6	0.9	1.3	-0.9	1.2	0.6
Leg fat percentage (left)	0.6	2.2	3.8	1.6	1.9	-0.6
Triglycerides	0.5	0.9	2.0	-0.5	-1.4	0.6
Systolic blood pressure, automated reading	0.5	1.6	4.0	2.0	-0.8	-0.2
Average weekly fortified wine intake	0.5	0.6	1.3	-1.1	0.7	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.9	-1.4	0.5	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	2.9	-1.7	0.7	0.3
Heart attack	0.5	0.7	1.4	-0.0	-1.2	-0.8
Fluid intelligence score	0.5	0.9	2.3	0.3	-0.6	1.5
Hair/balding pattern: Pattern 3	0.5	0.8	1.5	-1.2	-0.8	0.6
Impedance of arm (left)	0.5	2.5	5.3	-2.3	-1.3	0.8
Pulse wave reflection index	0.5	0.6	0.9	1.0	0.9	0.3
Number of children fathered	0.5	0.5	1.2	1.1	0.3	0.5
Shortness of breath walking on level ground	0.5	0.6	1.0	-1.0	0.8	0.5
Hypertension (Self-reported)	0.5	1.5	2.7	1.3	1.6	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	1.7	-1.3	-0.3	1.2
Miserableness	0.5	0.9	1.8	-1.4	0.0	0.9
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.1	1.1	-0.3	0.8
Medication: Lisinopril	0.5	0.7	1.5	-0.1	1.2	0.8
Illnesses of father: High blood pressure	0.5	0.6	1.1	1.1	0.8	-0.2
Irritability	0.5	0.8	2.0	0.2	0.6	1.4
Leg fat mass (left)	0.5	1.8	2.7	1.6	1.6	-0.4
Neuroticism (Nagel 2018)	0.4	0.9	1.4	-1.2	-0.3	1.1
Fasting Glucose	0.4	0.5	0.9	0.7	-0.2	0.9
Rheumatoid Arthritis	0.4	0.5	1.4	1.2	0.5	-0.1
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.8	0.7	-0.9	-0.1
Medication: Levothyroxine sodium	0.4	0.7	1.3	-1.1	-0.1	1.0
Qualifications: None of the above	0.4	0.8	1.9	0.5	1.4	-0.5
Mouth/teeth dental problems	0.4	0.6	1.8	1.4	0.1	0.1
Diabetes (self-reported)	0.4	0.6	1.7	-1.3	0.1	0.5
Neuroticism score	0.4	0.9	1.0	-1.0	-0.8	1.0
Impedance of arm (right)	0.4	2.0	2.8	-1.7	-1.7	0.6
Arm fat-free mass (right)	0.4	2.0	2.9	1.7	1.7	0.3
Medication: Omeprazole	0.4	0.5	1.3	1.2	0.0	-0.2
Leg fat mass (right)	0.4	1.7	2.7	1.6	1.5	-0.4
Arm predicted mass (right)	0.4	1.9	3.4	1.5	1.8	0.3
Pulse rate, automated reading	0.4	1.3	3.4	0.1	1.8	0.7
Knee pain experienced in last month	0.4	0.6	1.0	-0.9	-0.2	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.5	0.0	1.2	0.0
Commuting to job workplace: Public transport	0.4	0.4	1.2	-1.1	-0.4	-0.1
Arm fat-free mass (left)	0.4	2.3	4.0	2.0	1.7	0.1
Arm predicted mass (left)	0.4	2.2	3.3	1.8	1.6	0.7
Depressed Affect (Nagel 2018)	0.3	0.7	2.0	-1.4	0.3	0.1
Verbal and Numeric Reasoning (VNR)	0.3	0.8	2.2	-0.3	0.1	1.5
Neuroticism (2016)	0.3	0.5	0.9	0.3	-1.0	0.7
Hand grip strength (left)	0.3	0.8	1.3	-1.1	0.1	-1.1
Hearing difficulty/problems: Yes	0.3	0.5	0.9	1.0	-0.7	-0.2
Relative age of first facial hair	0.3	0.7	1.3	0.8	1.2	-0.3
Ever had hysterectomy (womb removed)	0.3	0.3	0.6	0.5	-0.3	-0.8
Hand grip strength (right)	0.3	0.7	1.2	-1.1	-0.9	-0.3
Age when periods started (menarche)	0.3	0.7	1.1	-1.1	-0.9	0.2
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.9	0.2	-1.0	0.4
Multivitamins +/- minerals	0.3	0.3	0.6	0.8	-0.1	0.6
Stomach or abdominal pain in last month	0.3	0.4	1.0	-1.0	-0.3	0.4
Medication: Atenolol	0.3	0.4	0.8	-0.3	-0.6	-0.9
Forced vital capacity (FVC)	0.3	1.0	2.3	0.4	1.5	-0.8
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.8	-0.2	-0.4	0.9
Trunk fat-free mass	0.3	1.5	3.8	1.9	0.8	0.3
Time employed in main current job	0.3	0.3	0.8	-0.3	0.2	0.9
Trunk predicted mass	0.3	1.5	3.7	1.9	0.9	0.4
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.7	0.4	0.9	-0.1
Medication: Amlodipine	0.3	0.4	0.7	0.6	0.9	0.3
Birth weight	0.3	0.7	1.6	-1.3	0.5	-0.4
Number of full brothers	0.3	0.4	1.1	-0.2	-0.2	-1.0
Health satisfaction	0.3	0.4	0.6	0.8	-0.3	-0.8
Medication for pain relief, constipation, heartburn	0.3	0.5	1.6	1.3	-0.1	0.1
Neck or shoulder pain in last month	0.3	0.4	0.9	0.5	1.0	-0.1
Medication: Allopurinol	0.3	0.4	0.6	0.6	0.8	-0.4
Medication: Seretide 50 evohaler	0.3	0.4	0.7	0.1	-0.7	0.8
Comparative height size at age 10	0.3	1.5	2.6	1.6	1.2	0.7
Family relationship satisfaction	0.3	0.3	0.6	0.8	-0.6	-0.1
Mood swings	0.3	0.6	1.2	-0.4	1.1	-0.6
Commuting to job workplace: Walk	0.3	0.3	0.6	0.4	0.3	-0.7
Financial situation satisfaction	0.3	0.4	1.2	0.1	0.1	-1.1
Fractured/broken bones in last 5 years	0.3	0.3	0.7	-0.9	0.2	-0.4
Age started oral contraceptive pill	0.3	0.3	0.5	-0.3	0.7	0.7
Supplements: Calcium	0.3	0.3	0.9	-0.2	0.0	0.9
Depression (Nagel 2018)	0.2	0.2	0.3	-0.6	0.6	-0.3
Alzheimer’s Disease (in father)	0.2	0.2	0.2	-0.5	0.5	-0.4
Mean Putamen Volume	0.2	0.2	0.3	0.2	0.5	0.6
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.8	0.0	-0.9	0.0
Systolic Blood Pressure	0.2	1.1	1.6	0.9	-0.9	-1.3
Hypothyroidism (self reported)	0.2	0.5	1.4	-1.2	-0.1	0.3
Tanning	0.2	1.9	5.2	0.0	0.6	2.3
Medication: Co-codamol	0.2	0.2	0.6	-0.2	-0.3	-0.8
Leg fat-free mass (left)	0.2	1.0	1.3	1.1	-0.6	1.1
Townsend deprivation index at recruitment	0.2	0.2	0.7	0.8	0.0	0.0
Maternal smoking around birth	0.2	0.3	0.6	-0.8	0.5	0.2
Fed-up feelings	0.2	0.3	0.6	-0.8	0.0	-0.6
Hayfever, allergic rhinitis or eczema	0.2	0.5	0.8	0.9	-0.7	0.3
Chronic bronchitis/emphysema (father)	0.2	0.3	0.8	-0.0	-0.2	0.9
High blood pressure (mother)	0.2	0.3	0.8	0.9	-0.3	0.0
Leg predicted mass (left)	0.2	0.9	1.3	1.1	-0.6	1.2
Nervous feelings	0.2	0.4	0.8	0.0	-0.6	0.9
Hearing difficulty/problems with background noise	0.2	0.4	0.6	0.7	-0.1	0.8
Allergy	0.2	0.4	0.8	0.6	0.9	0.1
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.4	0.7	-0.0	-0.4
Weight	0.2	1.1	2.7	1.6	0.8	0.3
Hip circumference	0.2	1.0	2.6	1.6	0.4	0.6
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.1	0.1	1.0	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.2	0.7	1.1	0.3
Hair/balding pattern: Pattern 4	0.2	0.5	1.1	-0.7	0.1	1.0
Headache pain in last month	0.2	0.3	0.8	-0.3	-0.3	-0.9
Forced vital capacity (FVC), Best measure	0.2	0.9	2.1	0.7	1.5	-0.2
Body fat percentage	0.2	0.9	1.6	0.9	1.3	-0.4
Comparative body size at age 10	0.2	0.6	0.8	-0.9	0.6	-0.8
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.5	-0.7	0.3	0.3
Medication: Ibuprofen	0.2	0.2	0.3	-0.5	-0.5	0.3
Whole body fat mass	0.2	0.9	1.3	1.1	1.1	-0.0
Alcohol intake frequency.	0.2	0.4	0.8	0.1	0.7	-0.9
Leg pain on walking	0.2	0.3	0.4	0.6	0.5	-0.4
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.6	-0.1	-0.3	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.8	-0.1	-0.9	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.2	0.1	1.1	0.5
Whole body fat-free mass	0.2	1.1	2.7	1.6	0.5	0.6
Leg fat-free mass (right)	0.2	0.8	1.5	0.8	-0.6	1.2
Diabetes diagnosed by doctor	0.2	0.4	0.9	-0.9	-0.3	-0.4
Mineral and other dietary supplements	0.2	0.2	0.4	-0.6	-0.4	-0.4
Osteoporosis (self-reported)	0.2	0.2	0.3	0.3	-0.5	0.5
Whole body water mass	0.2	1.0	2.5	1.6	0.5	0.6
Leg predicted mass (right)	0.2	0.8	1.5	0.8	-0.6	1.2
Medication: Blood pressure	0.2	0.4	0.5	0.7	0.7	0.3
Basal metabolic rate	0.2	1.0	2.6	1.6	0.6	0.5
Risk taking	0.2	0.2	0.5	-0.0	0.4	-0.7
Diastolic blood pressure, automated reading	0.2	0.6	1.4	1.2	0.2	-0.6
Unable to work because of sickness or disability	0.2	0.3	0.5	0.2	0.7	-0.4
Myopia	0.2	0.3	0.7	0.8	0.3	-0.3
Alcohol drinker status: Previous	0.2	0.2	0.3	-0.6	-0.4	0.4
Impedance of whole body	0.2	1.0	2.4	-1.5	0.7	-0.4
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.4	-0.5	-0.7	0.3
Schizophrenia vs Biploar Disorder	0.1	0.1	0.3	0.0	-0.6	0.0
Alzheimer’s Disease (in mother)	0.1	0.1	0.3	0.1	-0.6	0.0
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	-0.5	0.1	-0.4
HDL Cholesterol	0.1	0.1	0.3	-0.0	-0.1	-0.6
Lupus	0.1	0.1	0.3	-0.2	0.3	-0.6
BMI	0.1	0.5	1.1	1.1	-0.3	0.5
Height	0.1	2.3	4.5	2.1	1.2	-1.0
Allergy or Eczema	0.1	0.3	0.4	0.3	-0.6	0.6
Respiratory disease	0.1	0.1	0.4	-0.0	0.6	0.0
Lung FEV1/FVC ratio	0.1	0.5	1.0	-0.3	1.0	0.5
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	-0.3	0.3	0.4
Severe depression (siblings)	0.1	0.1	0.3	-0.2	-0.5	-0.1
Trunk fat percentage	0.1	0.4	0.8	0.6	0.9	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.5	-0.7	0.2	-0.6
Serious illness, injury or assault to yourself	0.1	0.1	0.3	0.2	0.5	-0.1
Sitting height	0.1	0.9	2.1	1.5	0.3	0.8
Body mass index (BMI)	0.1	0.5	1.2	1.1	0.4	0.2
Trunk fat mass	0.1	0.6	1.1	1.0	0.9	0.3
Waist circumference	0.1	0.5	0.8	0.9	0.4	-0.8
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	1.4	0.3	1.2	0.0
Pulse rate	0.1	0.2	0.6	-0.3	0.8	-0.1
Mouth/teeth dental problems: Dentures	0.1	0.1	0.4	0.1	-0.6	-0.0
Asthma	0.1	0.2	0.6	-0.8	0.3	0.0
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	-0.4	-0.0	0.3
Depression (self-reported)	0.1	0.2	0.5	-0.1	-0.1	0.7
Arm fat mass (right)	0.1	0.4	0.9	0.9	0.3	0.3
Standing height	0.1	1.2	2.1	1.4	1.0	0.6
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.2	-0.2	0.2	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.3	0.5	0.3	0.2
Number of full sisters	0.1	0.2	0.5	0.7	-0.2	0.1
Overall health rating	0.1	0.2	0.3	-0.3	0.4	-0.6
Illnesses of father: Heart disease	0.1	0.1	0.3	0.1	-0.2	-0.5
Asthma (self-reported)	0.1	0.2	0.4	-0.7	0.2	0.2
Arm fat mass (left)	0.1	0.4	0.9	0.9	0.5	0.3
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	0.1	0.4	-0.5
Pain experienced in last month	0.1	0.2	0.3	-0.5	-0.4	0.6
Major Depression (MDD)	0.0	0.1	0.2	0.0	-0.4	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Cardiovascular Disease	0.0	0.1	0.2	0.4	-0.2	0.3
Lung FVC	0.0	0.2	0.4	0.1	0.7	0.4
Hair Pigment	0.0	0.7	1.3	-0.8	1.2	0.2
Arm fat percentage (right)	0.0	0.1	0.3	0.5	-0.2	0.1
Tense / ‘highly strung’	0.0	0.1	0.1	-0.1	0.4	0.3
Medication for cholesterol, blood pressure or diabetes	0.0	0.1	0.1	-0.2	-0.3	-0.3
Arm fat percentage (left)	0.0	0.0	0.1	0.3	0.1	0.1
Number of self-reported non-cancer illnesses	0.0	0.0	0.0	-0.0	0.2	0.2

Hub : Genes

GBGT1

Models

Trait associations