Hub : Genes

RAPGEF1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellar Hemisphere 0.355 0.1620 1.0e-02 0.136 NA 0.091 NA 0.110 2.4e-04 NA 2.4e-03 NA 9.3e-04
2 GTEx Cells Transformed fibroblasts 0.108 0.0350 2.1e-04 0.046 NA 0.064 NA 0.047 2.2e-04 NA 1.6e-05 NA 1.9e-04
3 GTEx Muscle Skeletal 0.102 0.0303 1.7e-05 0.063 NA 0.068 NA 0.058 8.6e-07 NA 3.1e-07 NA 2.2e-06
4 GTEx Whole Blood 0.152 0.0390 2.2e-06 0.097 NA 0.045 NA 0.075 3.3e-09 NA 5.2e-05 NA 1.9e-07
5 NTR Blood 0.174 0.0258 0.0e+00 0.084 0.117 0.142 0.14 0.150 7.3e-26 1.3e-35 1.2e-43 7.1e-43 7.1e-46
6 TCGA Skin Cutaneous Melanoma 0.210 0.1100 4.8e-03 0.075 0.056 0.023 NA 0.058 4.9e-03 1.3e-02 8.0e-02 NA 1.2e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.4 0.7 4.1 -0.2 0.1 -0.1 -0.1 -2.0 0.2
Bipolar Disorder or Schizophrenia 0.8 2.0 6.1 -1.6 -0.3 1.4 -1.2 -2.5 0.3
Depressed Affect (Nagel 2018) 0.4 0.7 1.9 1.1 0.5 0.5 0.8 1.4 0.5
Depression (Nagel 2018) 0.3 0.5 1.4 -0.4 -0.7 1.2 -0.7 0.7 -0.3
Intelligence (Savage-Jansen 2018) 0.8 2.5 6.2 0.4 2.2 -0.4 1.3 -1.3 2.5
Neuroticism (Nagel 2018) 0.1 0.3 1.0 1.0 -0.2 0.5 0.2 0.8 -0.0
Schizophrenia (2018) 1.0 2.0 3.7 -1.9 -0.5 1.9 -1.4 -1.6 0.1
Schizophrenia vs Biploar Disorder 0.3 0.5 1.4 0.5 0.2 -1.2 0.3 1.0 0.1
Worry (Nagel 2018) 0.3 0.7 2.1 -0.3 -1.0 0.5 -0.8 -1.5 -0.4
Alzheimer’s Disease (in mother) 0.9 1.0 2.4 0.0 -1.2 -1.6 -0.8 -0.7 -1.0
Alzheimer’s Disease (in father) 1.9 2.0 3.8 0.7 1.9 -1.0 1.9 1.1 1.3
Alzheimer’s Disease (including proxy) 0.5 0.7 2.2 1.1 0.2 -1.5 0.6 0.4 0.3
Crohns Disease (2017) 0.8 1.7 4.5 0.6 -1.8 -0.7 -0.7 1.1 -2.1
Irritable Bowel Disease (IBD) 0.9 2.0 5.8 1.2 -1.8 -1.1 -0.5 0.7 -2.4
Ulcerative Colitis (UC) 0.4 0.8 2.2 0.9 -0.8 -1.0 0.2 0.1 -1.5
Major Depression (MDD) 0.8 0.9 1.7 1.2 1.3 -0.1 1.0 0.6 1.1
Reaction Time 0.9 1.6 3.4 -0.7 -1.8 -0.3 -1.8 -0.8 -1.4
Verbal and Numeric Reasoning (VNR) 0.2 0.5 1.4 -0.0 1.1 -0.1 0.4 -0.6 1.2
Breast Cancer 0.4 1.0 2.2 0.1 -1.1 -1.2 -1.0 -0.4 -1.5
Ovarian Cancer 0.6 0.7 1.2 0.3 -0.9 -1.1 0.2 1.1 -1.0
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 1.8 2.7 5.7 -0.3 2.4 0.5 2.2 0.7 2.1
Bipolar Disorder (2011) 0.3 0.3 0.5 0.6 0.7 0.2 0.7 -0.6 0.3
Body Mass Index (BMI) (2010) 0.3 0.4 0.8 -0.5 0.8 -0.3 0.9 0.0 0.7
Coronary Artery Disease (CAD) 1.0 1.2 2.3 0.4 -1.2 -0.8 -0.7 -1.4 -1.5
Crohns Disease (2012) 0.9 1.4 3.2 -0.3 -1.8 -0.0 -1.7 0.2 -1.5
Mean Putamen Volume 0.6 0.7 1.8 0.1 -0.9 0.4 -1.0 -1.4 -0.6
Fasting Glucose 0.2 0.3 0.8 -0.9 -0.2 0.3 -0.1 -0.5 -0.6
HbA1C 2.4 2.7 5.5 -2.3 -1.6 0.4 -1.6 -2.1 -1.1
HDL Cholesterol 0.3 0.6 1.3 1.1 -0.6 -0.8 0.1 0.3 -1.0
LDL Cholesterol 0.3 0.4 1.1 -1.0 -0.6 0.7 -0.5 -0.2 -0.6
Lupus 0.6 1.0 2.0 1.4 -0.6 -1.0 0.7 1.1 -1.0
Neuroticism (2016) 0.7 0.9 1.8 -0.6 1.2 1.4 0.9 -0.2 1.0
Primary Biliary Cirrhosis 0.2 0.3 0.7 0.9 0.4 -0.7 0.7 -0.1 0.1
Rheumatoid Arthritis 0.1 0.1 0.2 -0.4 -0.2 0.2 0.0 -0.2 -0.5
Schizophrenia (2014) 0.5 1.1 2.0 -1.3 0.2 1.4 -0.6 -1.2 0.7
Triglycerides 0.3 0.5 1.4 -1.2 0.4 1.0 0.1 0.3 0.4
Type 2 Diabetes (T2D) (2012) 0.5 0.5 1.1 0.4 0.6 1.0 0.7 0.9 0.4
Ulcerative Colitis 0.7 1.0 2.7 0.7 -0.2 -1.6 1.0 0.9 -0.9
Blood Eosinophil Count 1.3 9.9 28.1 -2.2 2.3 5.3 -0.9 -2.3 3.9
Blood Platelet Count 0.2 1.9 4.0 1.6 -1.3 -1.2 -0.0 -1.3 -2.0
Blood Red Count 0.4 4.3 7.6 -1.9 -2.3 1.9 -2.8 -2.0 -1.1
Blood White Count 0.7 5.5 14.1 0.1 2.2 3.4 0.4 -1.6 3.8
Heel T-Score 0.4 3.6 7.3 0.4 -2.6 -1.4 -1.8 1.2 -2.7
BMI 0.5 3.1 13.0 -1.8 0.5 3.6 -0.6 -0.6 1.1
Height 0.4 8.1 18.6 -1.5 4.3 2.7 1.6 0.5 4.2
Waist Hip Ratio (WHR) 0.3 1.4 3.8 1.3 1.3 0.4 2.0 0.9 0.9
Systolic Blood Pressure 1.0 5.2 16.2 4.0 1.2 -2.3 2.7 0.9 0.5
Smoking Status 0.5 1.2 3.7 -1.1 0.1 1.9 -0.4 1.2 0.5
Allergy or Eczema 1.2 3.2 5.7 1.2 2.0 -0.9 1.9 2.4 1.9
Cardiovascular Disease 0.6 2.1 4.7 0.8 1.7 1.5 1.1 0.8 2.2
Hypothyroidism (self reported) 0.5 1.2 2.5 0.3 -1.5 -1.1 -0.9 0.5 -1.6
Respiratory disease 1.4 3.1 6.9 0.2 2.6 0.3 2.6 0.6 2.1
Type 2 Diabetes (T2D) (2018) 1.9 3.6 6.7 -1.3 -2.6 1.7 -2.4 -0.8 -2.0
Lung FEV1/FVC ratio 0.1 0.6 3.5 0.5 0.0 -0.1 0.1 -1.9 0.3
Lung FVC 0.6 3.1 5.8 -1.2 -2.2 0.2 -2.4 -1.9 -1.7
Neuroticism 0.2 0.6 1.5 0.1 0.7 1.1 0.3 -0.6 1.2
Chronotype (morning person) 3.3 7.6 12.8 -2.6 -1.9 3.3 -3.6 -3.4 -0.6
Hair Pigment 0.1 4.1 7.7 0.4 2.8 1.2 1.9 2.3 2.5
Tanning 0.2 2.6 5.4 -2.3 -1.0 1.9 -1.9 -1.2 -0.4
Hand grip strength (left) 0.9 2.3 2.9 -1.7 -1.6 1.5 -1.7 -1.2 -1.3
Number of treatments/medications taken 1.5 2.7 4.3 1.1 2.1 0.1 1.9 1.9 1.9
Average weekly spirits intake 0.7 0.8 2.1 -1.0 1.1 0.9 0.2 0.2 1.5
Sensitivity / hurt feelings 0.4 0.7 1.8 -0.4 0.4 1.3 -0.2 -0.4 1.3
Frequency of depressed mood in last 2 weeks 0.8 1.2 4.0 -1.4 0.3 2.0 -0.6 -0.5 0.7
Hearing difficulty/problems: Yes 1.9 3.0 7.8 1.4 1.7 -2.1 2.8 0.6 0.6
Relative age of first facial hair 0.4 0.9 1.8 -0.4 1.4 0.2 1.2 -0.6 1.2
Other serious medical condition/disability diagnosed by doctor 2.3 3.0 5.4 1.1 2.3 -0.7 2.2 1.5 2.0
Ever used hormone-replacement therapy (HRT) 1.7 2.2 3.8 0.9 1.9 0.0 2.0 1.3 1.8
Ever had hysterectomy (womb removed) 0.9 1.0 2.2 0.6 0.9 -0.4 1.2 1.5 1.2
Systolic blood pressure, automated reading 0.9 2.5 7.8 2.8 1.4 -0.9 1.9 0.2 0.8
Eye problems/disorders: Diabetes related eye disease 1.4 1.6 4.3 0.1 -2.1 -0.2 -1.7 -0.1 -1.6
Angina 0.3 0.4 0.9 0.4 -0.9 -0.5 -0.3 -0.1 -1.0
Medication for hormone replacement therapy 3.6 4.0 10.6 3.3 1.4 -1.7 2.1 1.9 0.6
Vitamin and mineral supplements 1.6 2.2 5.3 -2.3 -1.4 -0.2 -0.6 -1.9 -1.4
Supplements: Zinc 3.0 3.3 5.5 1.3 1.8 -1.1 2.3 2.3 1.6
Medication: Co-codamol 0.8 0.9 2.6 -1.3 0.3 1.6 -0.5 -0.5 0.9
Medication: Metformin 1.0 1.4 3.3 -0.9 -1.6 0.9 -1.8 -0.6 -0.9
Diabetes (father) 2.8 3.4 7.8 -0.2 -2.8 -2.0 -1.3 -0.8 -2.5
Diabetes (mother) 0.2 0.3 1.1 -0.4 -0.6 -0.0 -0.4 -1.0 -0.3
Severe depression (siblings) 0.1 0.1 0.3 -0.5 -0.4 -0.2 -0.3 -0.5 0.1
Pack years adult smoking proportion 1.3 2.0 3.3 -1.3 -1.6 0.7 -1.8 -1.6 -1.2
Impedance of leg (right) 0.8 3.7 10.0 3.2 2.0 -1.4 1.8 0.2 1.6
Leg fat-free mass (left) 0.9 4.6 14.9 -3.1 0.5 3.9 -0.9 -0.3 1.2
Trunk fat percentage 2.1 8.3 19.4 0.1 4.4 2.6 2.3 -0.6 4.2
Hand grip strength (right) 1.1 2.9 5.1 -1.8 -2.1 1.2 -2.3 -1.1 -1.5
Townsend deprivation index at recruitment 0.4 0.5 1.1 -0.2 -0.8 -0.7 -0.6 -1.1 -0.7
Current tobacco smoking 1.4 2.3 5.2 -2.3 -0.6 2.1 -1.6 -1.1 0.1
Average weekly fortified wine intake 0.4 0.5 1.1 -0.9 -0.3 0.7 -0.7 -1.0 0.0
Maternal smoking around birth 2.3 3.3 8.3 0.7 -2.7 -1.4 -1.4 0.1 -2.9
Fed-up feelings 0.5 1.0 3.5 -0.8 -0.5 1.9 -0.9 -0.7 0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.4 2.4 -0.8 -1.5 1.4 -1.5 -0.7 -0.8
Relative age voice broke 0.3 0.4 0.9 -0.5 -0.6 -0.7 -0.0 -0.9 -0.7
Taking other prescription medications 1.0 1.6 3.8 0.4 1.3 -0.3 1.6 1.9 1.1
Age when periods started (menarche) 0.9 2.1 4.2 -0.7 -2.0 1.3 -1.7 -1.2 -1.4
Bilateral oophorectomy (both ovaries removed) 2.5 2.9 4.7 1.5 2.1 -0.3 2.2 1.4 1.9
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.2 3.3 0.3 -0.4 -1.8 0.9 1.2 -1.2
Tinnitus: Yes, but not now, but have in the past 0.9 0.9 1.7 1.2 0.4 -1.2 1.3 0.9 -0.0
Qualifications: CSEs or equivalent 1.3 1.8 4.6 -0.6 -2.1 0.5 -1.4 -0.4 -1.9
Serious illness, injury or assault to yourself 2.2 2.6 6.8 2.4 -0.1 -1.3 1.2 2.6 -0.6
High blood pressure 2.1 6.0 9.8 2.2 3.1 0.2 3.0 2.0 2.8
Hayfever, allergic rhinitis or eczema 1.0 2.1 3.7 1.1 1.7 -0.5 1.4 1.9 1.5
Multivitamins +/- minerals 0.8 1.1 1.8 1.0 1.3 0.7 0.1 1.2 1.3
Stomach or abdominal pain in last month 0.1 0.1 0.3 0.1 -0.1 0.3 -0.3 0.0 0.6
Supplements: Glucosamine 1.4 1.8 4.1 2.0 0.6 -1.4 0.9 1.9 -0.1
Diverticular disease/diverticulitis (self-reported) 1.0 1.1 2.3 -1.5 1.1 1.2 1.0 -0.3 0.9
Medication: Atenolol 0.7 0.9 2.2 0.7 0.6 -1.5 1.3 0.7 -0.3
Medication: Levothyroxine sodium 0.2 0.4 1.3 0.6 0.5 -0.1 0.1 1.1 0.7
Sitting height 0.2 1.2 3.3 -0.5 1.2 1.8 0.5 0.2 1.4
Chronic bronchitis/emphysema (father) 2.6 3.1 6.5 0.9 2.5 0.3 2.3 1.5 1.9
High blood pressure (mother) 1.0 1.4 5.2 2.3 -0.2 -0.8 1.0 1.2 -0.5
Body mass index (BMI) 0.7 2.8 8.8 -1.8 1.1 3.0 -0.0 -0.6 1.7
Impedance of leg (left) 0.7 3.2 8.6 2.9 2.1 -1.1 1.6 -0.1 1.7
Leg predicted mass (left) 0.9 4.7 15.3 -3.2 0.5 3.9 -0.9 -0.3 1.2
Trunk fat mass 1.7 7.5 15.1 -0.8 3.9 3.3 1.8 -0.5 3.9
Waist circumference 1.3 4.8 9.6 -0.7 2.9 2.6 1.8 0.1 3.1
Number of incorrect matches in round 0.1 0.2 0.9 0.9 0.3 -0.3 -0.2 0.2 0.2
Past tobacco smoking 0.8 1.5 2.6 0.1 -1.3 -0.7 -1.4 -1.6 -1.5
Alcohol usually taken with meals 0.6 1.0 4.1 0.8 0.6 -2.0 0.9 0.6 0.1
Nervous feelings 0.2 0.5 1.3 -0.5 -1.1 0.1 -0.7 -0.6 -0.7
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.4 4.0 -0.8 -1.1 2.0 -1.4 -0.7 -0.5
Hearing difficulty/problems with background noise 2.8 4.5 10.0 1.6 3.2 -0.4 2.6 1.3 2.4
Hair/balding pattern: Pattern 2 0.3 0.4 1.8 -1.3 0.1 0.4 -0.1 -0.3 0.3
Had menopause 0.8 1.0 2.2 -0.3 1.5 -0.5 1.1 0.4 1.4
Had other major operations 0.3 0.4 0.9 0.3 0.8 0.3 0.8 0.1 0.9
Forced vital capacity (FVC) 0.3 1.2 2.7 -0.7 -1.2 1.1 -1.6 -0.9 -0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.4 3.8 -0.4 -1.6 -1.2 -0.6 0.0 -2.0
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 0.9 0.0 -1.0 -0.2 -0.6 -0.2 -0.7
Qualifications: None of the above 0.1 0.3 1.1 -0.8 -0.0 1.0 -0.2 -0.3 0.0
Financial difficulties in last 2 years 1.3 1.7 7.0 -0.4 -0.5 2.6 -1.6 -0.1 0.5
Mouth/teeth dental problems 0.8 1.2 2.9 -0.4 -1.0 1.7 -1.0 -1.1 -0.9
Heart attack 1.0 1.3 2.8 -0.3 -1.7 -1.2 -0.6 0.6 -1.7
Allergy 1.7 3.9 6.9 -1.1 -2.6 0.3 -2.4 -1.7 -2.6
Pain all over the body in last month 1.1 1.2 3.8 -0.7 1.1 1.9 -0.1 -0.2 1.2
Diabetes (self-reported) 2.0 3.1 4.7 -1.4 -2.1 2.0 -2.2 -0.6 -1.7
Hayfever/allergic rhinitis (self-reported) 1.6 2.1 4.4 1.4 0.8 -1.8 1.5 2.1 0.4
Medication: Ramipril 1.1 1.4 3.5 1.0 0.2 -1.9 1.3 1.3 -0.5
Medication: Simvastatin 0.4 0.5 1.8 -0.6 -0.4 1.3 -0.9 0.1 0.2
Fluid intelligence score 1.0 2.0 5.8 0.1 2.3 0.5 0.8 -0.1 2.4
Illnesses of siblings 1.7 2.4 5.2 -0.3 -1.8 -2.3 -1.2 0.2 -2.0
Neuroticism score 0.3 0.5 1.4 0.4 0.7 1.0 0.2 -0.3 1.2
Weight 1.1 5.5 13.5 -2.2 2.5 3.7 0.8 -0.3 2.8
Impedance of arm (right) 1.5 7.2 11.4 3.4 3.3 -2.1 3.3 0.5 2.3
Arm fat percentage (right) 1.2 4.9 10.8 -0.4 3.1 2.2 1.9 -0.5 3.3
Trunk fat-free mass 0.8 4.9 15.4 -3.3 0.5 3.9 -0.9 0.4 1.3
Hip circumference 1.0 4.4 8.9 -1.0 3.0 1.9 1.8 0.8 3.0
Time employed in main current job 2.5 2.9 5.6 -1.0 -2.1 0.2 -2.4 -1.0 -2.3
Alcohol intake versus 10 years previously 0.1 0.1 0.2 0.3 -0.1 -0.4 -0.1 0.4 0.2
Father’s age at death 0.1 0.2 0.6 -0.8 -0.1 -0.2 -0.3 -0.6 0.1
Worrier / anxious feelings 0.2 0.3 1.0 -0.4 0.0 1.0 -0.3 -0.5 0.7
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.9 2.1 -0.2 0.9 1.4 0.4 0.4 1.4
Falls in the last year 0.3 0.3 1.1 0.1 0.0 0.2 1.0 1.0 -0.0
Hair/balding pattern: Pattern 3 0.4 0.6 1.1 0.3 -0.9 -0.3 -0.6 1.0 -1.0
Number of live births 0.7 0.9 2.1 0.5 0.7 -1.0 1.4 1.3 0.3
Forced expiratory volume in 1-second (FEV1) 0.5 1.8 3.7 -0.5 -1.6 1.2 -1.9 -1.4 -0.8
Pulse rate 0.9 1.6 3.8 0.5 1.9 0.1 1.2 -0.6 1.9
Happiness 0.0 0.0 0.1 -0.1 -0.1 0.3 -0.2 -0.2 -0.1
Noisy workplace 0.6 0.8 1.2 -1.1 0.9 1.1 0.7 -0.6 0.8
Qualifications: A levels/AS levels or equivalent 0.2 0.5 1.4 -0.4 1.2 -0.4 0.8 0.2 0.6
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 3.5 -0.2 -0.5 -1.9 0.9 0.5 -1.1
Mouth/teeth dental problems: Dentures 1.0 1.8 3.2 -1.0 -1.4 -1.8 -0.5 1.0 -1.8
Asthma 1.2 2.3 5.1 0.1 2.3 0.1 2.2 -0.1 1.9
Medication: Ibuprofen (e.g. Nurofen) 2.6 3.3 6.8 -0.4 2.0 2.6 1.5 -0.4 2.6
Medication: Cholesterol lowering 0.3 0.5 1.0 -0.7 -0.7 0.8 -1.0 0.3 -0.5
Depression (self-reported) 0.8 1.0 2.4 -0.5 -1.6 -1.1 -0.5 0.1 -1.4
Medication: Lansoprazole 1.5 1.7 3.7 -1.8 -0.8 1.9 -1.5 -0.6 -0.1
Prospective memory result 0.6 0.7 1.3 -0.3 0.8 1.1 0.7 1.0 1.0
Lung cancer (father) 0.5 0.6 2.5 -0.8 0.1 1.6 -0.3 -0.5 0.2
Illnesses of mother 1.8 2.2 6.5 -2.5 0.5 2.2 -0.8 -0.9 0.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 2.0 3.0 -1.2 -1.6 1.1 -1.7 -1.7 -1.0
Pulse wave Arterial Stiffness index 0.2 0.2 0.8 0.1 -0.4 0.9 -0.6 -0.2 -0.3
Impedance of arm (left) 1.4 6.6 10.7 3.2 3.1 -2.4 3.3 0.3 1.8
Arm fat mass (right) 1.2 4.9 9.7 -1.4 2.7 3.1 1.1 -0.2 3.1
Trunk predicted mass 0.8 4.7 15.3 -3.2 0.5 3.9 -0.8 0.5 1.3
Standing height 0.4 4.4 10.0 -1.1 3.2 2.2 1.6 0.7 2.8
Length of working week for main job 0.7 0.8 1.4 -1.2 -0.9 0.9 -0.8 -0.9 -0.4
Exposure to tobacco smoke at home 0.1 0.2 0.5 -0.0 0.1 0.2 0.7 0.6 0.3
Breastfed as a baby 2.0 2.5 5.9 -1.1 2.4 1.6 0.5 -0.8 2.1
Tense / ‘highly strung’ 0.8 1.4 4.2 -0.8 -0.2 1.6 -0.8 -2.1 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.5 3.9 -2.0 0.3 1.9 -0.2 -0.6 0.9
Hair/balding pattern: Pattern 4 0.5 1.3 3.3 -0.2 -1.5 -0.7 -0.8 -0.9 -1.8
Birth weight of first child 1.0 1.9 3.2 -1.4 -0.8 1.6 -1.6 -1.8 -0.7
Peak expiratory flow (PEF) 0.2 0.4 1.2 0.4 0.7 0.5 0.4 -0.5 1.1
Pulse wave reflection index 0.6 0.8 1.3 1.0 -1.0 -0.4 -0.5 0.9 -1.2
Ever highly irritable/argumentative for 2 days 1.2 1.5 2.8 -1.4 -1.4 -0.5 -0.7 -1.7 -1.1
Loud music exposure frequency 0.4 0.5 0.7 0.8 -0.8 0.4 -0.5 0.8 -0.7
Qualifications: O levels/GCSEs or equivalent 1.0 1.6 3.1 -1.5 -0.2 1.5 -1.8 -1.2 0.4
Mouth/teeth dental problems: Bleeding gums 0.9 1.1 2.0 1.2 1.3 -0.9 0.9 0.1 1.4
Blood clot in the leg (DVT) 0.9 1.1 2.2 -1.3 -0.5 0.9 -1.5 -1.1 0.9
Medication: Paracetamol 0.6 1.1 2.5 -0.1 1.0 1.4 0.5 -0.8 1.6
Headache pain in last month 0.1 0.1 0.2 -0.3 0.1 0.1 0.5 -0.3 0.4
Medication for cholesterol, blood pressure or diabetes 0.8 1.4 3.8 -1.6 -0.5 0.3 -1.4 -1.9 -0.1
Glaucoma (self-reported) 1.2 1.4 3.5 0.2 -1.5 -0.8 -1.4 0.5 -1.9
Gout (self-reported) 0.1 0.2 0.5 0.7 0.3 -0.2 0.2 -0.7 -0.1
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 0.8 0.7 -0.5 -0.6 -0.5 0.9 -0.6
Medication: Amlodipine 1.1 1.6 3.9 1.5 1.3 -0.8 2.0 0.3 0.9
Medication: Ventolin 100micrograms inhaler 1.0 1.2 3.1 0.5 1.5 -0.8 1.8 0.7 0.8
Birth weight 0.8 1.8 6.0 -1.5 0.9 2.5 -0.5 0.6 1.1
Chronic bronchitis/emphysema (mother) 0.6 0.7 1.2 1.1 -0.4 -1.1 -0.1 0.6 -1.0
High blood pressure (siblings) 2.8 4.0 8.0 1.1 2.2 2.8 1.4 0.2 2.8
Forced vital capacity (FVC), Best measure 0.4 1.6 2.5 -1.6 -0.9 1.4 -1.5 -1.4 -0.4
Body fat percentage 1.8 7.2 15.9 -0.1 4.0 2.7 2.1 -0.7 3.9
Leg fat percentage (right) 1.5 5.6 12.4 0.0 3.4 2.5 1.8 -0.1 3.5
Arm fat-free mass (right) 1.2 6.3 20.7 -3.6 0.2 4.5 -1.5 -0.6 1.1
Exposure to tobacco smoke outside home 0.1 0.2 0.5 -0.3 0.3 0.4 0.3 -0.4 0.7
Comparative body size at age 10 0.2 0.7 1.4 -0.7 0.7 1.1 -0.3 1.2 0.7
Number of full brothers 0.0 0.0 0.1 -0.2 0.0 0.1 -0.0 0.2 0.3
Worry too long after embarrassment 0.2 0.3 1.3 -0.3 0.1 -0.2 0.4 -1.1 0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 1.7 2.2 5.3 -2.3 -0.2 2.2 -0.8 -1.6 0.4
Wheeze or whistling in the chest in last year 0.4 0.8 1.9 0.2 1.4 0.9 1.0 0.1 1.0
Number of children fathered 0.3 0.4 0.8 0.5 -0.6 -0.3 0.1 0.9 -0.8
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.2 0.0 0.9 0.4 1.1 0.9 1.0
Age at first live birth 1.4 2.4 4.2 -1.4 2.0 1.6 1.3 -0.4 2.0
Pulse wave peak to peak time 0.1 0.2 0.5 -0.3 0.3 -0.7 0.3 0.0 0.4
Health satisfaction 2.6 3.4 7.5 1.0 2.7 0.3 1.7 1.7 2.4
Shortness of breath walking on level ground 0.2 0.3 0.8 0.0 -0.9 0.1 -0.5 0.1 -0.7
Qualifications: College or University degree 0.2 0.6 1.6 -0.3 1.3 0.0 1.0 -0.4 0.9
Eye problems/disorders: None of the above 4.3 5.0 14.2 -3.2 -0.8 1.0 -1.8 -3.8 -0.2
Mouth/teeth dental problems: Loose teeth 0.3 0.3 1.2 0.0 0.4 -0.7 1.1 -0.0 0.2
Emphysema/chronic bronchitis 1.0 1.2 3.3 1.0 -0.2 -1.8 1.1 1.1 -0.4
Medication for pain relief, constipation, heartburn 0.9 1.5 3.2 0.2 -1.4 -1.4 -1.3 0.2 -1.8
Neck or shoulder pain in last month 2.4 3.4 5.2 1.7 2.0 -0.4 2.2 2.3 1.6
Medication: Blood pressure 2.5 4.5 8.6 2.9 0.7 -1.9 2.5 2.8 -0.2
Angina (self-reported) 0.2 0.3 0.9 0.0 -1.0 -0.2 -0.6 -0.2 -0.8
Migraine (self-reported) 1.7 2.1 5.3 -1.5 -2.3 0.3 -1.4 -0.0 -1.8
Medication: Ibuprofen 1.2 1.5 5.4 -0.6 0.5 2.3 0.0 -1.1 1.3
Medication: Allopurinol 0.2 0.2 1.2 0.1 -0.2 -0.2 0.0 -1.1 -0.3
Medication: Omeprazole 0.6 0.8 2.5 -1.6 0.6 -0.1 0.4 -0.8 0.9
Medication: Seretide 50 evohaler 0.6 0.6 1.5 1.2 0.8 -0.5 1.0 0.6 0.3
Mean time to correctly identify matches 0.1 0.2 0.7 -0.1 -0.1 -0.8 -0.2 0.5 -0.1
Heart disease (mother) 3.3 4.1 10.2 3.2 0.1 -2.1 1.5 2.7 -0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 2.3 -0.2 0.1 0.1 0.9 1.5 0.0
Whole body fat mass 1.5 6.2 12.3 -1.1 3.3 3.3 1.3 -0.6 3.5
Leg fat mass (right) 1.3 4.9 11.4 -1.2 2.6 3.4 0.8 -0.6 3.0
Arm predicted mass (right) 1.2 6.1 21.4 -3.4 0.5 4.6 -1.4 -0.4 1.3
Pulse rate, automated reading 0.7 2.2 6.0 0.6 1.7 0.5 0.6 -2.4 1.9
Alcohol intake frequency. 0.3 0.7 1.4 -0.2 -1.0 0.1 -1.1 -1.2 -0.6
Comparative height size at age 10 1.2 6.4 13.7 -1.0 3.7 1.9 2.1 2.1 3.3
Number of full sisters 0.4 0.5 2.1 0.1 0.4 0.6 0.2 1.4 0.3
Suffer from ‘nerves’ 0.5 0.8 3.1 -0.4 0.5 1.7 -0.0 -0.7 1.0
Overall health rating 0.9 2.0 4.4 0.4 2.1 0.2 1.7 0.4 2.1
Chest pain or discomfort 0.9 1.2 3.3 1.4 -0.3 -1.8 0.7 -0.7 -1.0
Had major operations 0.9 1.1 2.8 1.1 -0.7 -1.7 0.4 1.0 -0.9
Age at last live birth 0.8 1.1 2.7 -0.3 1.7 0.6 1.3 0.7 1.2
Family relationship satisfaction 0.3 0.3 0.5 0.6 -0.7 -0.6 -0.5 0.3 -0.6
Leg pain on walking 1.7 2.1 4.5 -1.9 0.8 2.1 0.1 1.0 1.7
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 2.3 0.1 -0.6 -1.1 -0.0 1.5 -0.5
Commuting to job workplace: Car/motor vehicle 0.2 0.3 1.2 -1.1 -0.5 0.1 -0.5 -0.1 0.1
Illness, injury, bereavement, stress in last 2 years 0.9 1.1 3.5 -0.6 0.8 0.7 -0.2 -1.9 1.3
Medication: Aspirin 1.3 1.7 3.3 1.6 1.3 -0.3 1.8 1.5 0.7
Supplements: Vitamin C 0.6 0.7 2.9 1.7 0.1 1.0 -0.2 0.6 0.1
Knee pain experienced in last month 0.3 0.4 0.9 0.2 0.9 0.8 0.4 0.9 0.4
Hypertension (Self-reported) 2.1 5.9 9.6 2.4 3.0 -0.2 3.1 2.1 2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.0 3.2 -1.6 0.1 1.8 -0.5 0.1 0.5
Illnesses of father: Heart disease 2.0 2.8 6.3 1.9 -0.3 -1.9 1.4 2.5 -1.1
Illnesses of siblings: Diabetes 1.2 1.5 2.5 -1.6 -1.2 0.7 -0.7 -1.6 -1.2
Smoking status: Previous 0.9 1.3 2.3 0.8 1.2 -0.0 1.5 1.3 1.3
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.6 5.6 -1.8 0.2 2.4 -0.3 -0.5 0.7
Whole body fat-free mass 1.0 5.5 17.7 -3.5 0.5 4.2 -1.0 0.1 1.3
Leg fat-free mass (right) 0.8 4.4 13.8 -3.3 0.2 3.7 -1.1 -0.4 1.0
Arm fat percentage (left) 1.3 5.1 10.7 -0.4 3.3 2.2 2.0 -0.6 3.2
Average weekly red wine intake 1.1 1.6 4.5 0.4 -0.1 -2.1 1.7 0.7 -1.2
Handedness (chirality/laterality): Left-handed 0.7 0.8 1.8 -1.3 -0.9 0.1 -0.9 -1.1 -0.7
Mood swings 0.6 1.0 3.2 1.8 0.7 0.1 1.0 0.5 1.0
Loneliness, isolation 0.6 0.9 3.3 -0.2 0.0 1.8 -1.0 -0.6 0.5
Long-standing illness, disability or infirmity 0.3 0.5 1.0 -0.4 0.7 0.4 0.9 1.0 0.5
Ever had bowel cancer screening 0.5 0.5 1.7 -0.0 0.9 0.5 0.6 0.3 1.3
Diabetes diagnosed by doctor 1.6 2.6 4.8 -1.1 -2.2 1.4 -2.1 -0.3 -1.7
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 1.7 1.3 -0.1 -0.6 0.5 0.6 -0.0
Friendships satisfaction 0.1 0.1 0.6 0.4 -0.1 0.1 -0.1 0.8 0.0
Qualifications: nursing, teaching 0.4 0.6 1.4 -0.5 0.7 0.3 -0.5 -1.0 1.2
Commuting to job workplace: Walk 0.5 0.6 1.4 0.3 0.6 -1.2 1.1 -0.5 -0.2
Eye problems/disorders: Cataract 5.8 6.7 13.9 2.6 2.4 -0.8 3.2 3.7 1.7
Mouth/teeth dental problems: Mouth ulcers 1.6 2.6 5.2 1.2 2.3 -0.5 1.9 0.6 2.1
Medication for cholesterol 2.9 4.4 6.7 -2.6 -2.4 0.5 -2.6 -2.1 -1.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.1 3.7 0.3 -1.1 -1.9 -0.4 -0.1 -1.0
Back pain experienced in last month 0.2 0.3 0.8 0.2 0.4 0.9 0.5 0.1 0.6
Mineral and other dietary supplements 2.2 3.0 5.6 -2.4 -1.7 1.1 -1.5 -2.1 -1.2
Breast cancer (self-reported) 0.2 0.3 0.8 0.8 0.5 0.0 0.0 0.3 0.9
Asthma (self-reported) 1.2 2.4 5.7 0.0 2.3 -0.1 2.4 -0.1 1.9
Osteoporosis (self-reported) 3.8 4.7 7.8 1.6 2.7 -0.3 2.8 2.1 2.5
Osteoarthritis (self-reported) 0.7 0.9 2.4 -0.3 1.1 -0.6 1.5 0.7 0.9
Medication: Aspirin 0.8 1.1 2.1 1.3 1.1 -0.4 1.5 1.0 0.6
Medication: Gliclazide 0.7 0.8 1.2 0.9 -1.0 -0.9 -0.1 0.9 -1.1
Illnesses of father: None of the above (group 1) 2.2 2.8 5.8 -1.7 -1.1 1.1 -2.3 -2.4 -0.4
Smoking status: Current 1.2 1.9 4.7 -2.1 -0.4 2.2 -1.3 -0.6 0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 1.9 -0.5 -1.4 0.2 -1.1 -1.2 -1.3
Whole body water mass 1.0 5.5 17.7 -3.5 0.4 4.2 -1.1 0.0 1.2
Leg predicted mass (right) 0.9 4.6 14.3 -3.3 0.2 3.8 -1.2 -0.3 1.0
Arm fat mass (left) 1.3 5.4 11.6 -1.7 2.7 3.4 1.0 -0.6 3.0
Number of self-reported non-cancer illnesses 2.6 4.5 9.0 1.5 2.0 -0.9 2.8 3.0 1.8
Average weekly champagne plus white wine intake 0.3 0.4 1.5 -0.2 -0.6 0.6 -1.2 0.1 -0.1
Miserableness 0.5 0.9 2.5 1.6 -0.0 -0.9 0.8 1.3 -0.2
Guilty feelings 0.3 0.4 1.1 1.1 -0.3 -0.4 0.3 1.0 -0.4
Wears glasses or contact lenses 0.3 0.3 0.7 -0.3 0.8 0.0 0.5 -0.8 0.4
Ever taken oral contraceptive pill 1.1 1.2 2.6 -0.1 -1.6 -0.4 -1.2 -0.8 -1.4
Hearing aid user 1.2 1.3 3.1 0.2 -1.5 -1.8 -0.1 0.5 -1.5
Mother’s age at death 0.6 0.7 1.2 0.9 0.8 -0.8 0.9 1.1 0.3
Financial situation satisfaction 0.8 1.0 3.5 -1.9 -0.3 1.3 -0.7 -0.3 0.1
Tinnitus: Yes, now most or all of the time 2.2 2.6 7.7 -2.8 -0.1 1.8 -1.3 -1.6 0.7
Commuting to job workplace: Public transport 0.5 0.6 1.1 -1.1 1.0 -0.3 -0.1 -0.8 0.8
Eye problems/disorders: Glaucoma 0.8 1.0 2.3 0.4 -1.2 -0.5 -1.1 0.8 -1.5
Medication: Blood pressure 2.4 4.5 8.5 1.8 2.9 0.6 2.4 1.7 2.5
Pain type(s) experienced in last month: Hip pain 2.0 2.6 4.6 -1.6 1.0 1.9 -0.5 -2.1 1.8
Supplements: Fish oil (including cod liver oil) 0.8 1.1 2.6 0.6 1.6 -0.2 0.7 0.7 1.6
High cholesterol (Self-reported) 0.2 0.3 1.3 -0.4 -0.0 1.1 -0.5 0.2 0.4
Medication: Bendroflumethiazide 0.6 0.9 1.7 0.6 1.0 0.5 1.2 0.8 1.3
Medication: Paracetamol 0.5 0.7 1.8 0.1 0.8 1.3 0.4 -0.2 1.3
Medication: Lisinopril 0.5 0.7 1.7 1.3 0.1 -0.8 0.5 1.3 -0.2
Medication: Atorvastatin 0.4 0.4 0.9 -0.8 0.2 0.6 -0.5 -0.9 0.6
Illnesses of father: High blood pressure 0.8 0.9 1.9 0.3 1.0 0.8 1.0 1.0 1.4
Alcohol drinker status: Never 2.1 2.5 5.7 -1.0 -2.4 -0.0 -1.8 -1.1 -1.9
Ever smoked 1.2 2.0 4.5 -1.2 1.7 1.4 0.9 0.8 2.1
Basal metabolic rate 1.0 5.4 17.5 -3.3 0.8 4.2 -0.8 -0.2 1.6
Leg fat percentage (left) 1.7 6.1 13.3 -0.2 3.5 2.8 1.7 -0.2 3.6
Arm fat-free mass (left) 1.2 6.3 21.5 -3.3 0.9 4.6 -0.9 -0.1 1.9
Number of operations (self-reported) 0.1 0.2 0.7 0.2 0.5 -0.3 0.3 -0.2 0.8
Average weekly beer plus cider intake 0.6 0.9 2.2 -0.1 -1.5 -0.7 -1.0 0.1 -1.4
Irritability 0.2 0.3 0.7 0.7 0.1 -0.6 0.8 0.5 -0.1
Risk taking 1.4 2.0 5.5 2.3 0.9 -1.1 1.6 1.3 0.4
Ever had prostate specific antigen (PSA) test 0.5 0.6 2.8 1.7 0.3 -0.3 0.7 0.6 -0.0
Fractured/broken bones in last 5 years 1.5 1.9 3.5 1.4 1.4 -0.3 1.8 1.9 1.0
Age started oral contraceptive pill 0.4 0.5 1.1 1.1 0.8 -0.4 0.8 0.3 0.6
Diastolic blood pressure, automated reading 0.2 0.8 2.9 1.7 0.5 0.3 0.5 -0.7 0.7
Ever depressed for a whole week 0.4 0.5 1.2 1.0 -0.3 -0.5 0.3 1.1 -0.6
Unable to work because of sickness or disability 0.1 0.2 0.3 -0.1 -0.6 -0.0 0.2 0.5 -0.6
Commuting to job workplace: Cycle 0.0 0.0 0.1 -0.0 -0.3 0.1 -0.2 -0.0 -0.3
Myopia 1.8 2.7 4.9 -1.3 -1.5 0.2 -2.0 -2.2 -1.8
Vascular/heart problems diagnosed by doctor 1.6 4.5 8.8 -1.4 -3.0 -0.7 -2.4 -1.3 -2.9
Cholesterol lowering medication 0.9 1.3 2.8 0.1 1.2 1.6 0.1 0.9 1.7
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 2.3 -1.5 0.1 -0.3 0.3 -0.5 0.4
Pain experienced in last month 1.7 2.8 4.7 -0.9 -2.1 -1.4 -1.4 -1.8 -2.2
Supplements: Calcium 0.9 1.0 2.6 1.4 -0.2 -0.8 0.6 1.6 -0.3
Basal cell carcinoma (self-reported) 1.2 1.4 3.6 -0.5 1.2 1.2 0.3 1.3 1.9
Heart attack/myocardial infarction (self-reported) 0.7 1.0 1.9 -0.3 -1.4 -1.1 -0.5 0.6 -1.4
Deep venous thrombosis (DVT) (self-reported) 1.7 2.2 5.5 -1.7 -1.5 0.8 -2.3 -1.5 0.0
Heart disease (siblings) 0.4 0.5 1.0 -0.4 -0.9 -1.0 0.1 -0.3 -1.0
Alcohol drinker status: Previous 0.3 0.3 1.0 1.0 -0.1 -0.4 0.5 0.3 -0.5
Pack years of smoking 0.8 1.2 2.5 -1.2 -0.9 0.6 -1.3 -1.6 -0.7
Impedance of whole body 0.9 4.4 9.1 3.0 2.4 -1.9 2.2 -0.5 1.6
Leg fat mass (left) 1.3 5.1 12.0 -1.4 2.6 3.5 0.7 -0.7 3.0
Arm predicted mass (left) 1.2 5.9 19.8 -3.4 0.6 4.5 -1.1 -0.1 1.5