Hub : Genes

RAPGEF1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.355	0.1620	1.0e-02	0.136	NA	0.091	NA	0.110	2.4e-04	NA	2.4e-03	NA	9.3e-04
2	GTEx	Cells Transformed fibroblasts	0.108	0.0350	2.1e-04	0.046	NA	0.064	NA	0.047	2.2e-04	NA	1.6e-05	NA	1.9e-04
3	GTEx	Muscle Skeletal	0.102	0.0303	1.7e-05	0.063	NA	0.068	NA	0.058	8.6e-07	NA	3.1e-07	NA	2.2e-06
4	GTEx	Whole Blood	0.152	0.0390	2.2e-06	0.097	NA	0.045	NA	0.075	3.3e-09	NA	5.2e-05	NA	1.9e-07
5	NTR	Blood	0.174	0.0258	0.0e+00	0.084	0.117	0.142	0.14	0.150	7.3e-26	1.3e-35	1.2e-43	7.1e-43	7.1e-46
6	TCGA	Skin Cutaneous Melanoma	0.210	0.1100	4.8e-03	0.075	0.056	0.023	NA	0.058	4.9e-03	1.3e-02	8.0e-02	NA	1.2e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.4	0.7	4.1	-0.2	0.1	-0.1	-0.1	-2.0	0.2
Bipolar Disorder or Schizophrenia	0.8	2.0	6.1	-1.6	-0.3	1.4	-1.2	-2.5	0.3
Depressed Affect (Nagel 2018)	0.4	0.7	1.9	1.1	0.5	0.5	0.8	1.4	0.5
Depression (Nagel 2018)	0.3	0.5	1.4	-0.4	-0.7	1.2	-0.7	0.7	-0.3
Intelligence (Savage-Jansen 2018)	0.8	2.5	6.2	0.4	2.2	-0.4	1.3	-1.3	2.5
Neuroticism (Nagel 2018)	0.1	0.3	1.0	1.0	-0.2	0.5	0.2	0.8	-0.0
Schizophrenia (2018)	1.0	2.0	3.7	-1.9	-0.5	1.9	-1.4	-1.6	0.1
Schizophrenia vs Biploar Disorder	0.3	0.5	1.4	0.5	0.2	-1.2	0.3	1.0	0.1
Worry (Nagel 2018)	0.3	0.7	2.1	-0.3	-1.0	0.5	-0.8	-1.5	-0.4
Alzheimer’s Disease (in mother)	0.9	1.0	2.4	0.0	-1.2	-1.6	-0.8	-0.7	-1.0
Alzheimer’s Disease (in father)	1.9	2.0	3.8	0.7	1.9	-1.0	1.9	1.1	1.3
Alzheimer’s Disease (including proxy)	0.5	0.7	2.2	1.1	0.2	-1.5	0.6	0.4	0.3
Crohns Disease (2017)	0.8	1.7	4.5	0.6	-1.8	-0.7	-0.7	1.1	-2.1
Irritable Bowel Disease (IBD)	0.9	2.0	5.8	1.2	-1.8	-1.1	-0.5	0.7	-2.4
Ulcerative Colitis (UC)	0.4	0.8	2.2	0.9	-0.8	-1.0	0.2	0.1	-1.5
Major Depression (MDD)	0.8	0.9	1.7	1.2	1.3	-0.1	1.0	0.6	1.1
Reaction Time	0.9	1.6	3.4	-0.7	-1.8	-0.3	-1.8	-0.8	-1.4
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.4	-0.0	1.1	-0.1	0.4	-0.6	1.2
Breast Cancer	0.4	1.0	2.2	0.1	-1.1	-1.2	-1.0	-0.4	-1.5
Ovarian Cancer	0.6	0.7	1.2	0.3	-0.9	-1.1	0.2	1.1	-1.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.8	2.7	5.7	-0.3	2.4	0.5	2.2	0.7	2.1
Bipolar Disorder (2011)	0.3	0.3	0.5	0.6	0.7	0.2	0.7	-0.6	0.3
Body Mass Index (BMI) (2010)	0.3	0.4	0.8	-0.5	0.8	-0.3	0.9	0.0	0.7
Coronary Artery Disease (CAD)	1.0	1.2	2.3	0.4	-1.2	-0.8	-0.7	-1.4	-1.5
Crohns Disease (2012)	0.9	1.4	3.2	-0.3	-1.8	-0.0	-1.7	0.2	-1.5
Mean Putamen Volume	0.6	0.7	1.8	0.1	-0.9	0.4	-1.0	-1.4	-0.6
Fasting Glucose	0.2	0.3	0.8	-0.9	-0.2	0.3	-0.1	-0.5	-0.6
HbA1C	2.4	2.7	5.5	-2.3	-1.6	0.4	-1.6	-2.1	-1.1
HDL Cholesterol	0.3	0.6	1.3	1.1	-0.6	-0.8	0.1	0.3	-1.0
LDL Cholesterol	0.3	0.4	1.1	-1.0	-0.6	0.7	-0.5	-0.2	-0.6
Lupus	0.6	1.0	2.0	1.4	-0.6	-1.0	0.7	1.1	-1.0
Neuroticism (2016)	0.7	0.9	1.8	-0.6	1.2	1.4	0.9	-0.2	1.0
Primary Biliary Cirrhosis	0.2	0.3	0.7	0.9	0.4	-0.7	0.7	-0.1	0.1
Rheumatoid Arthritis	0.1	0.1	0.2	-0.4	-0.2	0.2	0.0	-0.2	-0.5
Schizophrenia (2014)	0.5	1.1	2.0	-1.3	0.2	1.4	-0.6	-1.2	0.7
Triglycerides	0.3	0.5	1.4	-1.2	0.4	1.0	0.1	0.3	0.4
Type 2 Diabetes (T2D) (2012)	0.5	0.5	1.1	0.4	0.6	1.0	0.7	0.9	0.4
Ulcerative Colitis	0.7	1.0	2.7	0.7	-0.2	-1.6	1.0	0.9	-0.9
Blood Eosinophil Count	1.3	9.9	28.1	-2.2	2.3	5.3	-0.9	-2.3	3.9
Blood Platelet Count	0.2	1.9	4.0	1.6	-1.3	-1.2	-0.0	-1.3	-2.0
Blood Red Count	0.4	4.3	7.6	-1.9	-2.3	1.9	-2.8	-2.0	-1.1
Blood White Count	0.7	5.5	14.1	0.1	2.2	3.4	0.4	-1.6	3.8
Heel T-Score	0.4	3.6	7.3	0.4	-2.6	-1.4	-1.8	1.2	-2.7
BMI	0.5	3.1	13.0	-1.8	0.5	3.6	-0.6	-0.6	1.1
Height	0.4	8.1	18.6	-1.5	4.3	2.7	1.6	0.5	4.2
Waist Hip Ratio (WHR)	0.3	1.4	3.8	1.3	1.3	0.4	2.0	0.9	0.9
Systolic Blood Pressure	1.0	5.2	16.2	4.0	1.2	-2.3	2.7	0.9	0.5
Smoking Status	0.5	1.2	3.7	-1.1	0.1	1.9	-0.4	1.2	0.5
Allergy or Eczema	1.2	3.2	5.7	1.2	2.0	-0.9	1.9	2.4	1.9
Cardiovascular Disease	0.6	2.1	4.7	0.8	1.7	1.5	1.1	0.8	2.2
Hypothyroidism (self reported)	0.5	1.2	2.5	0.3	-1.5	-1.1	-0.9	0.5	-1.6
Respiratory disease	1.4	3.1	6.9	0.2	2.6	0.3	2.6	0.6	2.1
Type 2 Diabetes (T2D) (2018)	1.9	3.6	6.7	-1.3	-2.6	1.7	-2.4	-0.8	-2.0
Lung FEV1/FVC ratio	0.1	0.6	3.5	0.5	0.0	-0.1	0.1	-1.9	0.3
Lung FVC	0.6	3.1	5.8	-1.2	-2.2	0.2	-2.4	-1.9	-1.7
Neuroticism	0.2	0.6	1.5	0.1	0.7	1.1	0.3	-0.6	1.2
Chronotype (morning person)	3.3	7.6	12.8	-2.6	-1.9	3.3	-3.6	-3.4	-0.6
Hair Pigment	0.1	4.1	7.7	0.4	2.8	1.2	1.9	2.3	2.5
Tanning	0.2	2.6	5.4	-2.3	-1.0	1.9	-1.9	-1.2	-0.4
Hand grip strength (left)	0.9	2.3	2.9	-1.7	-1.6	1.5	-1.7	-1.2	-1.3
Number of treatments/medications taken	1.5	2.7	4.3	1.1	2.1	0.1	1.9	1.9	1.9
Average weekly spirits intake	0.7	0.8	2.1	-1.0	1.1	0.9	0.2	0.2	1.5
Sensitivity / hurt feelings	0.4	0.7	1.8	-0.4	0.4	1.3	-0.2	-0.4	1.3
Frequency of depressed mood in last 2 weeks	0.8	1.2	4.0	-1.4	0.3	2.0	-0.6	-0.5	0.7
Hearing difficulty/problems: Yes	1.9	3.0	7.8	1.4	1.7	-2.1	2.8	0.6	0.6
Relative age of first facial hair	0.4	0.9	1.8	-0.4	1.4	0.2	1.2	-0.6	1.2
Other serious medical condition/disability diagnosed by doctor	2.3	3.0	5.4	1.1	2.3	-0.7	2.2	1.5	2.0
Ever used hormone-replacement therapy (HRT)	1.7	2.2	3.8	0.9	1.9	0.0	2.0	1.3	1.8
Ever had hysterectomy (womb removed)	0.9	1.0	2.2	0.6	0.9	-0.4	1.2	1.5	1.2
Systolic blood pressure, automated reading	0.9	2.5	7.8	2.8	1.4	-0.9	1.9	0.2	0.8
Eye problems/disorders: Diabetes related eye disease	1.4	1.6	4.3	0.1	-2.1	-0.2	-1.7	-0.1	-1.6
Angina	0.3	0.4	0.9	0.4	-0.9	-0.5	-0.3	-0.1	-1.0
Medication for hormone replacement therapy	3.6	4.0	10.6	3.3	1.4	-1.7	2.1	1.9	0.6
Vitamin and mineral supplements	1.6	2.2	5.3	-2.3	-1.4	-0.2	-0.6	-1.9	-1.4
Supplements: Zinc	3.0	3.3	5.5	1.3	1.8	-1.1	2.3	2.3	1.6
Medication: Co-codamol	0.8	0.9	2.6	-1.3	0.3	1.6	-0.5	-0.5	0.9
Medication: Metformin	1.0	1.4	3.3	-0.9	-1.6	0.9	-1.8	-0.6	-0.9
Diabetes (father)	2.8	3.4	7.8	-0.2	-2.8	-2.0	-1.3	-0.8	-2.5
Diabetes (mother)	0.2	0.3	1.1	-0.4	-0.6	-0.0	-0.4	-1.0	-0.3
Severe depression (siblings)	0.1	0.1	0.3	-0.5	-0.4	-0.2	-0.3	-0.5	0.1
Pack years adult smoking proportion	1.3	2.0	3.3	-1.3	-1.6	0.7	-1.8	-1.6	-1.2
Impedance of leg (right)	0.8	3.7	10.0	3.2	2.0	-1.4	1.8	0.2	1.6
Leg fat-free mass (left)	0.9	4.6	14.9	-3.1	0.5	3.9	-0.9	-0.3	1.2
Trunk fat percentage	2.1	8.3	19.4	0.1	4.4	2.6	2.3	-0.6	4.2
Hand grip strength (right)	1.1	2.9	5.1	-1.8	-2.1	1.2	-2.3	-1.1	-1.5
Townsend deprivation index at recruitment	0.4	0.5	1.1	-0.2	-0.8	-0.7	-0.6	-1.1	-0.7
Current tobacco smoking	1.4	2.3	5.2	-2.3	-0.6	2.1	-1.6	-1.1	0.1
Average weekly fortified wine intake	0.4	0.5	1.1	-0.9	-0.3	0.7	-0.7	-1.0	0.0
Maternal smoking around birth	2.3	3.3	8.3	0.7	-2.7	-1.4	-1.4	0.1	-2.9
Fed-up feelings	0.5	1.0	3.5	-0.8	-0.5	1.9	-0.9	-0.7	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	2.4	-0.8	-1.5	1.4	-1.5	-0.7	-0.8
Relative age voice broke	0.3	0.4	0.9	-0.5	-0.6	-0.7	-0.0	-0.9	-0.7
Taking other prescription medications	1.0	1.6	3.8	0.4	1.3	-0.3	1.6	1.9	1.1
Age when periods started (menarche)	0.9	2.1	4.2	-0.7	-2.0	1.3	-1.7	-1.2	-1.4
Bilateral oophorectomy (both ovaries removed)	2.5	2.9	4.7	1.5	2.1	-0.3	2.2	1.4	1.9
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	3.3	0.3	-0.4	-1.8	0.9	1.2	-1.2
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	1.7	1.2	0.4	-1.2	1.3	0.9	-0.0
Qualifications: CSEs or equivalent	1.3	1.8	4.6	-0.6	-2.1	0.5	-1.4	-0.4	-1.9
Serious illness, injury or assault to yourself	2.2	2.6	6.8	2.4	-0.1	-1.3	1.2	2.6	-0.6
High blood pressure	2.1	6.0	9.8	2.2	3.1	0.2	3.0	2.0	2.8
Hayfever, allergic rhinitis or eczema	1.0	2.1	3.7	1.1	1.7	-0.5	1.4	1.9	1.5
Multivitamins +/- minerals	0.8	1.1	1.8	1.0	1.3	0.7	0.1	1.2	1.3
Stomach or abdominal pain in last month	0.1	0.1	0.3	0.1	-0.1	0.3	-0.3	0.0	0.6
Supplements: Glucosamine	1.4	1.8	4.1	2.0	0.6	-1.4	0.9	1.9	-0.1
Diverticular disease/diverticulitis (self-reported)	1.0	1.1	2.3	-1.5	1.1	1.2	1.0	-0.3	0.9
Medication: Atenolol	0.7	0.9	2.2	0.7	0.6	-1.5	1.3	0.7	-0.3
Medication: Levothyroxine sodium	0.2	0.4	1.3	0.6	0.5	-0.1	0.1	1.1	0.7
Sitting height	0.2	1.2	3.3	-0.5	1.2	1.8	0.5	0.2	1.4
Chronic bronchitis/emphysema (father)	2.6	3.1	6.5	0.9	2.5	0.3	2.3	1.5	1.9
High blood pressure (mother)	1.0	1.4	5.2	2.3	-0.2	-0.8	1.0	1.2	-0.5
Body mass index (BMI)	0.7	2.8	8.8	-1.8	1.1	3.0	-0.0	-0.6	1.7
Impedance of leg (left)	0.7	3.2	8.6	2.9	2.1	-1.1	1.6	-0.1	1.7
Leg predicted mass (left)	0.9	4.7	15.3	-3.2	0.5	3.9	-0.9	-0.3	1.2
Trunk fat mass	1.7	7.5	15.1	-0.8	3.9	3.3	1.8	-0.5	3.9
Waist circumference	1.3	4.8	9.6	-0.7	2.9	2.6	1.8	0.1	3.1
Number of incorrect matches in round	0.1	0.2	0.9	0.9	0.3	-0.3	-0.2	0.2	0.2
Past tobacco smoking	0.8	1.5	2.6	0.1	-1.3	-0.7	-1.4	-1.6	-1.5
Alcohol usually taken with meals	0.6	1.0	4.1	0.8	0.6	-2.0	0.9	0.6	0.1
Nervous feelings	0.2	0.5	1.3	-0.5	-1.1	0.1	-0.7	-0.6	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	4.0	-0.8	-1.1	2.0	-1.4	-0.7	-0.5
Hearing difficulty/problems with background noise	2.8	4.5	10.0	1.6	3.2	-0.4	2.6	1.3	2.4
Hair/balding pattern: Pattern 2	0.3	0.4	1.8	-1.3	0.1	0.4	-0.1	-0.3	0.3
Had menopause	0.8	1.0	2.2	-0.3	1.5	-0.5	1.1	0.4	1.4
Had other major operations	0.3	0.4	0.9	0.3	0.8	0.3	0.8	0.1	0.9
Forced vital capacity (FVC)	0.3	1.2	2.7	-0.7	-1.2	1.1	-1.6	-0.9	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	3.8	-0.4	-1.6	-1.2	-0.6	0.0	-2.0
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.9	0.0	-1.0	-0.2	-0.6	-0.2	-0.7
Qualifications: None of the above	0.1	0.3	1.1	-0.8	-0.0	1.0	-0.2	-0.3	0.0
Financial difficulties in last 2 years	1.3	1.7	7.0	-0.4	-0.5	2.6	-1.6	-0.1	0.5
Mouth/teeth dental problems	0.8	1.2	2.9	-0.4	-1.0	1.7	-1.0	-1.1	-0.9
Heart attack	1.0	1.3	2.8	-0.3	-1.7	-1.2	-0.6	0.6	-1.7
Allergy	1.7	3.9	6.9	-1.1	-2.6	0.3	-2.4	-1.7	-2.6
Pain all over the body in last month	1.1	1.2	3.8	-0.7	1.1	1.9	-0.1	-0.2	1.2
Diabetes (self-reported)	2.0	3.1	4.7	-1.4	-2.1	2.0	-2.2	-0.6	-1.7
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	4.4	1.4	0.8	-1.8	1.5	2.1	0.4
Medication: Ramipril	1.1	1.4	3.5	1.0	0.2	-1.9	1.3	1.3	-0.5
Medication: Simvastatin	0.4	0.5	1.8	-0.6	-0.4	1.3	-0.9	0.1	0.2
Fluid intelligence score	1.0	2.0	5.8	0.1	2.3	0.5	0.8	-0.1	2.4
Illnesses of siblings	1.7	2.4	5.2	-0.3	-1.8	-2.3	-1.2	0.2	-2.0
Neuroticism score	0.3	0.5	1.4	0.4	0.7	1.0	0.2	-0.3	1.2
Weight	1.1	5.5	13.5	-2.2	2.5	3.7	0.8	-0.3	2.8
Impedance of arm (right)	1.5	7.2	11.4	3.4	3.3	-2.1	3.3	0.5	2.3
Arm fat percentage (right)	1.2	4.9	10.8	-0.4	3.1	2.2	1.9	-0.5	3.3
Trunk fat-free mass	0.8	4.9	15.4	-3.3	0.5	3.9	-0.9	0.4	1.3
Hip circumference	1.0	4.4	8.9	-1.0	3.0	1.9	1.8	0.8	3.0
Time employed in main current job	2.5	2.9	5.6	-1.0	-2.1	0.2	-2.4	-1.0	-2.3
Alcohol intake versus 10 years previously	0.1	0.1	0.2	0.3	-0.1	-0.4	-0.1	0.4	0.2
Father’s age at death	0.1	0.2	0.6	-0.8	-0.1	-0.2	-0.3	-0.6	0.1
Worrier / anxious feelings	0.2	0.3	1.0	-0.4	0.0	1.0	-0.3	-0.5	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	2.1	-0.2	0.9	1.4	0.4	0.4	1.4
Falls in the last year	0.3	0.3	1.1	0.1	0.0	0.2	1.0	1.0	-0.0
Hair/balding pattern: Pattern 3	0.4	0.6	1.1	0.3	-0.9	-0.3	-0.6	1.0	-1.0
Number of live births	0.7	0.9	2.1	0.5	0.7	-1.0	1.4	1.3	0.3
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	3.7	-0.5	-1.6	1.2	-1.9	-1.4	-0.8
Pulse rate	0.9	1.6	3.8	0.5	1.9	0.1	1.2	-0.6	1.9
Happiness	0.0	0.0	0.1	-0.1	-0.1	0.3	-0.2	-0.2	-0.1
Noisy workplace	0.6	0.8	1.2	-1.1	0.9	1.1	0.7	-0.6	0.8
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.4	-0.4	1.2	-0.4	0.8	0.2	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	3.5	-0.2	-0.5	-1.9	0.9	0.5	-1.1
Mouth/teeth dental problems: Dentures	1.0	1.8	3.2	-1.0	-1.4	-1.8	-0.5	1.0	-1.8
Asthma	1.2	2.3	5.1	0.1	2.3	0.1	2.2	-0.1	1.9
Medication: Ibuprofen (e.g. Nurofen)	2.6	3.3	6.8	-0.4	2.0	2.6	1.5	-0.4	2.6
Medication: Cholesterol lowering	0.3	0.5	1.0	-0.7	-0.7	0.8	-1.0	0.3	-0.5
Depression (self-reported)	0.8	1.0	2.4	-0.5	-1.6	-1.1	-0.5	0.1	-1.4
Medication: Lansoprazole	1.5	1.7	3.7	-1.8	-0.8	1.9	-1.5	-0.6	-0.1
Prospective memory result	0.6	0.7	1.3	-0.3	0.8	1.1	0.7	1.0	1.0
Lung cancer (father)	0.5	0.6	2.5	-0.8	0.1	1.6	-0.3	-0.5	0.2
Illnesses of mother	1.8	2.2	6.5	-2.5	0.5	2.2	-0.8	-0.9	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	3.0	-1.2	-1.6	1.1	-1.7	-1.7	-1.0
Pulse wave Arterial Stiffness index	0.2	0.2	0.8	0.1	-0.4	0.9	-0.6	-0.2	-0.3
Impedance of arm (left)	1.4	6.6	10.7	3.2	3.1	-2.4	3.3	0.3	1.8
Arm fat mass (right)	1.2	4.9	9.7	-1.4	2.7	3.1	1.1	-0.2	3.1
Trunk predicted mass	0.8	4.7	15.3	-3.2	0.5	3.9	-0.8	0.5	1.3
Standing height	0.4	4.4	10.0	-1.1	3.2	2.2	1.6	0.7	2.8
Length of working week for main job	0.7	0.8	1.4	-1.2	-0.9	0.9	-0.8	-0.9	-0.4
Exposure to tobacco smoke at home	0.1	0.2	0.5	-0.0	0.1	0.2	0.7	0.6	0.3
Breastfed as a baby	2.0	2.5	5.9	-1.1	2.4	1.6	0.5	-0.8	2.1
Tense / ‘highly strung’	0.8	1.4	4.2	-0.8	-0.2	1.6	-0.8	-2.1	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	3.9	-2.0	0.3	1.9	-0.2	-0.6	0.9
Hair/balding pattern: Pattern 4	0.5	1.3	3.3	-0.2	-1.5	-0.7	-0.8	-0.9	-1.8
Birth weight of first child	1.0	1.9	3.2	-1.4	-0.8	1.6	-1.6	-1.8	-0.7
Peak expiratory flow (PEF)	0.2	0.4	1.2	0.4	0.7	0.5	0.4	-0.5	1.1
Pulse wave reflection index	0.6	0.8	1.3	1.0	-1.0	-0.4	-0.5	0.9	-1.2
Ever highly irritable/argumentative for 2 days	1.2	1.5	2.8	-1.4	-1.4	-0.5	-0.7	-1.7	-1.1
Loud music exposure frequency	0.4	0.5	0.7	0.8	-0.8	0.4	-0.5	0.8	-0.7
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	3.1	-1.5	-0.2	1.5	-1.8	-1.2	0.4
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	2.0	1.2	1.3	-0.9	0.9	0.1	1.4
Blood clot in the leg (DVT)	0.9	1.1	2.2	-1.3	-0.5	0.9	-1.5	-1.1	0.9
Medication: Paracetamol	0.6	1.1	2.5	-0.1	1.0	1.4	0.5	-0.8	1.6
Headache pain in last month	0.1	0.1	0.2	-0.3	0.1	0.1	0.5	-0.3	0.4
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	3.8	-1.6	-0.5	0.3	-1.4	-1.9	-0.1
Glaucoma (self-reported)	1.2	1.4	3.5	0.2	-1.5	-0.8	-1.4	0.5	-1.9
Gout (self-reported)	0.1	0.2	0.5	0.7	0.3	-0.2	0.2	-0.7	-0.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.8	0.7	-0.5	-0.6	-0.5	0.9	-0.6
Medication: Amlodipine	1.1	1.6	3.9	1.5	1.3	-0.8	2.0	0.3	0.9
Medication: Ventolin 100micrograms inhaler	1.0	1.2	3.1	0.5	1.5	-0.8	1.8	0.7	0.8
Birth weight	0.8	1.8	6.0	-1.5	0.9	2.5	-0.5	0.6	1.1
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.2	1.1	-0.4	-1.1	-0.1	0.6	-1.0
High blood pressure (siblings)	2.8	4.0	8.0	1.1	2.2	2.8	1.4	0.2	2.8
Forced vital capacity (FVC), Best measure	0.4	1.6	2.5	-1.6	-0.9	1.4	-1.5	-1.4	-0.4
Body fat percentage	1.8	7.2	15.9	-0.1	4.0	2.7	2.1	-0.7	3.9
Leg fat percentage (right)	1.5	5.6	12.4	0.0	3.4	2.5	1.8	-0.1	3.5
Arm fat-free mass (right)	1.2	6.3	20.7	-3.6	0.2	4.5	-1.5	-0.6	1.1
Exposure to tobacco smoke outside home	0.1	0.2	0.5	-0.3	0.3	0.4	0.3	-0.4	0.7
Comparative body size at age 10	0.2	0.7	1.4	-0.7	0.7	1.1	-0.3	1.2	0.7
Number of full brothers	0.0	0.0	0.1	-0.2	0.0	0.1	-0.0	0.2	0.3
Worry too long after embarrassment	0.2	0.3	1.3	-0.3	0.1	-0.2	0.4	-1.1	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.2	5.3	-2.3	-0.2	2.2	-0.8	-1.6	0.4
Wheeze or whistling in the chest in last year	0.4	0.8	1.9	0.2	1.4	0.9	1.0	0.1	1.0
Number of children fathered	0.3	0.4	0.8	0.5	-0.6	-0.3	0.1	0.9	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.2	0.0	0.9	0.4	1.1	0.9	1.0
Age at first live birth	1.4	2.4	4.2	-1.4	2.0	1.6	1.3	-0.4	2.0
Pulse wave peak to peak time	0.1	0.2	0.5	-0.3	0.3	-0.7	0.3	0.0	0.4
Health satisfaction	2.6	3.4	7.5	1.0	2.7	0.3	1.7	1.7	2.4
Shortness of breath walking on level ground	0.2	0.3	0.8	0.0	-0.9	0.1	-0.5	0.1	-0.7
Qualifications: College or University degree	0.2	0.6	1.6	-0.3	1.3	0.0	1.0	-0.4	0.9
Eye problems/disorders: None of the above	4.3	5.0	14.2	-3.2	-0.8	1.0	-1.8	-3.8	-0.2
Mouth/teeth dental problems: Loose teeth	0.3	0.3	1.2	0.0	0.4	-0.7	1.1	-0.0	0.2
Emphysema/chronic bronchitis	1.0	1.2	3.3	1.0	-0.2	-1.8	1.1	1.1	-0.4
Medication for pain relief, constipation, heartburn	0.9	1.5	3.2	0.2	-1.4	-1.4	-1.3	0.2	-1.8
Neck or shoulder pain in last month	2.4	3.4	5.2	1.7	2.0	-0.4	2.2	2.3	1.6
Medication: Blood pressure	2.5	4.5	8.6	2.9	0.7	-1.9	2.5	2.8	-0.2
Angina (self-reported)	0.2	0.3	0.9	0.0	-1.0	-0.2	-0.6	-0.2	-0.8
Migraine (self-reported)	1.7	2.1	5.3	-1.5	-2.3	0.3	-1.4	-0.0	-1.8
Medication: Ibuprofen	1.2	1.5	5.4	-0.6	0.5	2.3	0.0	-1.1	1.3
Medication: Allopurinol	0.2	0.2	1.2	0.1	-0.2	-0.2	0.0	-1.1	-0.3
Medication: Omeprazole	0.6	0.8	2.5	-1.6	0.6	-0.1	0.4	-0.8	0.9
Medication: Seretide 50 evohaler	0.6	0.6	1.5	1.2	0.8	-0.5	1.0	0.6	0.3
Mean time to correctly identify matches	0.1	0.2	0.7	-0.1	-0.1	-0.8	-0.2	0.5	-0.1
Heart disease (mother)	3.3	4.1	10.2	3.2	0.1	-2.1	1.5	2.7	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	2.3	-0.2	0.1	0.1	0.9	1.5	0.0
Whole body fat mass	1.5	6.2	12.3	-1.1	3.3	3.3	1.3	-0.6	3.5
Leg fat mass (right)	1.3	4.9	11.4	-1.2	2.6	3.4	0.8	-0.6	3.0
Arm predicted mass (right)	1.2	6.1	21.4	-3.4	0.5	4.6	-1.4	-0.4	1.3
Pulse rate, automated reading	0.7	2.2	6.0	0.6	1.7	0.5	0.6	-2.4	1.9
Alcohol intake frequency.	0.3	0.7	1.4	-0.2	-1.0	0.1	-1.1	-1.2	-0.6
Comparative height size at age 10	1.2	6.4	13.7	-1.0	3.7	1.9	2.1	2.1	3.3
Number of full sisters	0.4	0.5	2.1	0.1	0.4	0.6	0.2	1.4	0.3
Suffer from ‘nerves’	0.5	0.8	3.1	-0.4	0.5	1.7	-0.0	-0.7	1.0
Overall health rating	0.9	2.0	4.4	0.4	2.1	0.2	1.7	0.4	2.1
Chest pain or discomfort	0.9	1.2	3.3	1.4	-0.3	-1.8	0.7	-0.7	-1.0
Had major operations	0.9	1.1	2.8	1.1	-0.7	-1.7	0.4	1.0	-0.9
Age at last live birth	0.8	1.1	2.7	-0.3	1.7	0.6	1.3	0.7	1.2
Family relationship satisfaction	0.3	0.3	0.5	0.6	-0.7	-0.6	-0.5	0.3	-0.6
Leg pain on walking	1.7	2.1	4.5	-1.9	0.8	2.1	0.1	1.0	1.7
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	2.3	0.1	-0.6	-1.1	-0.0	1.5	-0.5
Commuting to job workplace: Car/motor vehicle	0.2	0.3	1.2	-1.1	-0.5	0.1	-0.5	-0.1	0.1
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	3.5	-0.6	0.8	0.7	-0.2	-1.9	1.3
Medication: Aspirin	1.3	1.7	3.3	1.6	1.3	-0.3	1.8	1.5	0.7
Supplements: Vitamin C	0.6	0.7	2.9	1.7	0.1	1.0	-0.2	0.6	0.1
Knee pain experienced in last month	0.3	0.4	0.9	0.2	0.9	0.8	0.4	0.9	0.4
Hypertension (Self-reported)	2.1	5.9	9.6	2.4	3.0	-0.2	3.1	2.1	2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	3.2	-1.6	0.1	1.8	-0.5	0.1	0.5
Illnesses of father: Heart disease	2.0	2.8	6.3	1.9	-0.3	-1.9	1.4	2.5	-1.1
Illnesses of siblings: Diabetes	1.2	1.5	2.5	-1.6	-1.2	0.7	-0.7	-1.6	-1.2
Smoking status: Previous	0.9	1.3	2.3	0.8	1.2	-0.0	1.5	1.3	1.3
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	5.6	-1.8	0.2	2.4	-0.3	-0.5	0.7
Whole body fat-free mass	1.0	5.5	17.7	-3.5	0.5	4.2	-1.0	0.1	1.3
Leg fat-free mass (right)	0.8	4.4	13.8	-3.3	0.2	3.7	-1.1	-0.4	1.0
Arm fat percentage (left)	1.3	5.1	10.7	-0.4	3.3	2.2	2.0	-0.6	3.2
Average weekly red wine intake	1.1	1.6	4.5	0.4	-0.1	-2.1	1.7	0.7	-1.2
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.8	-1.3	-0.9	0.1	-0.9	-1.1	-0.7
Mood swings	0.6	1.0	3.2	1.8	0.7	0.1	1.0	0.5	1.0
Loneliness, isolation	0.6	0.9	3.3	-0.2	0.0	1.8	-1.0	-0.6	0.5
Long-standing illness, disability or infirmity	0.3	0.5	1.0	-0.4	0.7	0.4	0.9	1.0	0.5
Ever had bowel cancer screening	0.5	0.5	1.7	-0.0	0.9	0.5	0.6	0.3	1.3
Diabetes diagnosed by doctor	1.6	2.6	4.8	-1.1	-2.2	1.4	-2.1	-0.3	-1.7
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.7	1.3	-0.1	-0.6	0.5	0.6	-0.0
Friendships satisfaction	0.1	0.1	0.6	0.4	-0.1	0.1	-0.1	0.8	0.0
Qualifications: nursing, teaching	0.4	0.6	1.4	-0.5	0.7	0.3	-0.5	-1.0	1.2
Commuting to job workplace: Walk	0.5	0.6	1.4	0.3	0.6	-1.2	1.1	-0.5	-0.2
Eye problems/disorders: Cataract	5.8	6.7	13.9	2.6	2.4	-0.8	3.2	3.7	1.7
Mouth/teeth dental problems: Mouth ulcers	1.6	2.6	5.2	1.2	2.3	-0.5	1.9	0.6	2.1
Medication for cholesterol	2.9	4.4	6.7	-2.6	-2.4	0.5	-2.6	-2.1	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	3.7	0.3	-1.1	-1.9	-0.4	-0.1	-1.0
Back pain experienced in last month	0.2	0.3	0.8	0.2	0.4	0.9	0.5	0.1	0.6
Mineral and other dietary supplements	2.2	3.0	5.6	-2.4	-1.7	1.1	-1.5	-2.1	-1.2
Breast cancer (self-reported)	0.2	0.3	0.8	0.8	0.5	0.0	0.0	0.3	0.9
Asthma (self-reported)	1.2	2.4	5.7	0.0	2.3	-0.1	2.4	-0.1	1.9
Osteoporosis (self-reported)	3.8	4.7	7.8	1.6	2.7	-0.3	2.8	2.1	2.5
Osteoarthritis (self-reported)	0.7	0.9	2.4	-0.3	1.1	-0.6	1.5	0.7	0.9
Medication: Aspirin	0.8	1.1	2.1	1.3	1.1	-0.4	1.5	1.0	0.6
Medication: Gliclazide	0.7	0.8	1.2	0.9	-1.0	-0.9	-0.1	0.9	-1.1
Illnesses of father: None of the above (group 1)	2.2	2.8	5.8	-1.7	-1.1	1.1	-2.3	-2.4	-0.4
Smoking status: Current	1.2	1.9	4.7	-2.1	-0.4	2.2	-1.3	-0.6	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	1.9	-0.5	-1.4	0.2	-1.1	-1.2	-1.3
Whole body water mass	1.0	5.5	17.7	-3.5	0.4	4.2	-1.1	0.0	1.2
Leg predicted mass (right)	0.9	4.6	14.3	-3.3	0.2	3.8	-1.2	-0.3	1.0
Arm fat mass (left)	1.3	5.4	11.6	-1.7	2.7	3.4	1.0	-0.6	3.0
Number of self-reported non-cancer illnesses	2.6	4.5	9.0	1.5	2.0	-0.9	2.8	3.0	1.8
Average weekly champagne plus white wine intake	0.3	0.4	1.5	-0.2	-0.6	0.6	-1.2	0.1	-0.1
Miserableness	0.5	0.9	2.5	1.6	-0.0	-0.9	0.8	1.3	-0.2
Guilty feelings	0.3	0.4	1.1	1.1	-0.3	-0.4	0.3	1.0	-0.4
Wears glasses or contact lenses	0.3	0.3	0.7	-0.3	0.8	0.0	0.5	-0.8	0.4
Ever taken oral contraceptive pill	1.1	1.2	2.6	-0.1	-1.6	-0.4	-1.2	-0.8	-1.4
Hearing aid user	1.2	1.3	3.1	0.2	-1.5	-1.8	-0.1	0.5	-1.5
Mother’s age at death	0.6	0.7	1.2	0.9	0.8	-0.8	0.9	1.1	0.3
Financial situation satisfaction	0.8	1.0	3.5	-1.9	-0.3	1.3	-0.7	-0.3	0.1
Tinnitus: Yes, now most or all of the time	2.2	2.6	7.7	-2.8	-0.1	1.8	-1.3	-1.6	0.7
Commuting to job workplace: Public transport	0.5	0.6	1.1	-1.1	1.0	-0.3	-0.1	-0.8	0.8
Eye problems/disorders: Glaucoma	0.8	1.0	2.3	0.4	-1.2	-0.5	-1.1	0.8	-1.5
Medication: Blood pressure	2.4	4.5	8.5	1.8	2.9	0.6	2.4	1.7	2.5
Pain type(s) experienced in last month: Hip pain	2.0	2.6	4.6	-1.6	1.0	1.9	-0.5	-2.1	1.8
Supplements: Fish oil (including cod liver oil)	0.8	1.1	2.6	0.6	1.6	-0.2	0.7	0.7	1.6
High cholesterol (Self-reported)	0.2	0.3	1.3	-0.4	-0.0	1.1	-0.5	0.2	0.4
Medication: Bendroflumethiazide	0.6	0.9	1.7	0.6	1.0	0.5	1.2	0.8	1.3
Medication: Paracetamol	0.5	0.7	1.8	0.1	0.8	1.3	0.4	-0.2	1.3
Medication: Lisinopril	0.5	0.7	1.7	1.3	0.1	-0.8	0.5	1.3	-0.2
Medication: Atorvastatin	0.4	0.4	0.9	-0.8	0.2	0.6	-0.5	-0.9	0.6
Illnesses of father: High blood pressure	0.8	0.9	1.9	0.3	1.0	0.8	1.0	1.0	1.4
Alcohol drinker status: Never	2.1	2.5	5.7	-1.0	-2.4	-0.0	-1.8	-1.1	-1.9
Ever smoked	1.2	2.0	4.5	-1.2	1.7	1.4	0.9	0.8	2.1
Basal metabolic rate	1.0	5.4	17.5	-3.3	0.8	4.2	-0.8	-0.2	1.6
Leg fat percentage (left)	1.7	6.1	13.3	-0.2	3.5	2.8	1.7	-0.2	3.6
Arm fat-free mass (left)	1.2	6.3	21.5	-3.3	0.9	4.6	-0.9	-0.1	1.9
Number of operations (self-reported)	0.1	0.2	0.7	0.2	0.5	-0.3	0.3	-0.2	0.8
Average weekly beer plus cider intake	0.6	0.9	2.2	-0.1	-1.5	-0.7	-1.0	0.1	-1.4
Irritability	0.2	0.3	0.7	0.7	0.1	-0.6	0.8	0.5	-0.1
Risk taking	1.4	2.0	5.5	2.3	0.9	-1.1	1.6	1.3	0.4
Ever had prostate specific antigen (PSA) test	0.5	0.6	2.8	1.7	0.3	-0.3	0.7	0.6	-0.0
Fractured/broken bones in last 5 years	1.5	1.9	3.5	1.4	1.4	-0.3	1.8	1.9	1.0
Age started oral contraceptive pill	0.4	0.5	1.1	1.1	0.8	-0.4	0.8	0.3	0.6
Diastolic blood pressure, automated reading	0.2	0.8	2.9	1.7	0.5	0.3	0.5	-0.7	0.7
Ever depressed for a whole week	0.4	0.5	1.2	1.0	-0.3	-0.5	0.3	1.1	-0.6
Unable to work because of sickness or disability	0.1	0.2	0.3	-0.1	-0.6	-0.0	0.2	0.5	-0.6
Commuting to job workplace: Cycle	0.0	0.0	0.1	-0.0	-0.3	0.1	-0.2	-0.0	-0.3
Myopia	1.8	2.7	4.9	-1.3	-1.5	0.2	-2.0	-2.2	-1.8
Vascular/heart problems diagnosed by doctor	1.6	4.5	8.8	-1.4	-3.0	-0.7	-2.4	-1.3	-2.9
Cholesterol lowering medication	0.9	1.3	2.8	0.1	1.2	1.6	0.1	0.9	1.7
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	2.3	-1.5	0.1	-0.3	0.3	-0.5	0.4
Pain experienced in last month	1.7	2.8	4.7	-0.9	-2.1	-1.4	-1.4	-1.8	-2.2
Supplements: Calcium	0.9	1.0	2.6	1.4	-0.2	-0.8	0.6	1.6	-0.3
Basal cell carcinoma (self-reported)	1.2	1.4	3.6	-0.5	1.2	1.2	0.3	1.3	1.9
Heart attack/myocardial infarction (self-reported)	0.7	1.0	1.9	-0.3	-1.4	-1.1	-0.5	0.6	-1.4
Deep venous thrombosis (DVT) (self-reported)	1.7	2.2	5.5	-1.7	-1.5	0.8	-2.3	-1.5	0.0
Heart disease (siblings)	0.4	0.5	1.0	-0.4	-0.9	-1.0	0.1	-0.3	-1.0
Alcohol drinker status: Previous	0.3	0.3	1.0	1.0	-0.1	-0.4	0.5	0.3	-0.5
Pack years of smoking	0.8	1.2	2.5	-1.2	-0.9	0.6	-1.3	-1.6	-0.7
Impedance of whole body	0.9	4.4	9.1	3.0	2.4	-1.9	2.2	-0.5	1.6
Leg fat mass (left)	1.3	5.1	12.0	-1.4	2.6	3.5	0.7	-0.7	3.0
Arm predicted mass (left)	1.2	5.9	19.8	-3.4	0.6	4.5	-1.1	-0.1	1.5