Hub : Genes

RCOR1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 YFS Blood 0.0374 0.0157 0.0035 0.018 0.011 0.016 0.015 0.015 1.2e-06 0.00012 3.8e-06 6.2e-06 1e-05
2 TCGA Cervical Squamous Cell Carcinoma 0.2250 0.1020 0.0052 0.064 0.032 0.041 NA 0.065 4.3e-04 0.01000 4.1e-03 NA 4e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.9 1.4 1.5 -1.2 1.2
Bipolar Disorder or Schizophrenia 0.7 1.6 2.2 -1.5 1.0
Depressed Affect (Nagel 2018) 0.0 0.0 0.0 0.1 0.2
Depression (Nagel 2018) 0.8 1.2 1.4 1.0 -1.2
Intelligence (Savage-Jansen 2018) 0.3 0.8 1.5 -1.2 0.3
Neuroticism (Nagel 2018) 0.4 0.9 1.0 1.0 -1.0
Schizophrenia (2018) 0.2 0.5 0.8 -0.9 0.4
Schizophrenia vs Biploar Disorder 0.8 1.0 1.4 1.2 -0.8
Worry (Nagel 2018) 0.9 1.8 2.0 1.3 -1.4
Alzheimer’s Disease (in mother) 0.6 0.7 1.4 -0.2 1.2
Alzheimer’s Disease (in father) 0.1 0.1 0.1 -0.3 0.3
Alzheimer’s Disease (including proxy) 0.8 1.2 2.2 -0.3 1.5
Crohns Disease (2017) 0.2 0.4 0.6 -0.4 0.8
Irritable Bowel Disease (IBD) 0.7 1.8 2.1 -1.5 1.2
Ulcerative Colitis (UC) 1.6 3.0 3.8 -2.0 1.4
Major Depression (MDD) 0.2 0.2 0.4 0.2 -0.6
Reaction Time 0.7 1.3 1.4 1.1 -1.2
Verbal and Numeric Reasoning (VNR) 0.5 1.2 1.7 -0.8 1.3
Breast Cancer 0.1 0.3 0.5 -0.3 0.7
Ovarian Cancer 0.4 0.6 0.8 -0.5 0.9
Prostate Cancer 0.0 0.0 0.0 0.1 -0.1
Age at First Birth 1.0 1.5 1.5 1.2 -1.2
Bipolar Disorder (2011) 2.3 2.2 3.5 -1.9 1.0
Body Mass Index (BMI) (2010) 0.1 0.2 0.3 0.3 -0.5
Coronary Artery Disease (CAD) 0.1 0.1 0.1 -0.2 0.4
Crohns Disease (2012) 0.2 0.4 0.4 0.6 -0.6
Mean Putamen Volume 1.1 1.2 2.0 1.4 0.7
Fasting Glucose 0.9 1.0 1.5 0.7 -1.2
HbA1C 1.7 1.8 3.3 1.8 -0.6
HDL Cholesterol 0.2 0.3 0.5 -0.1 0.7
LDL Cholesterol 0.6 0.9 1.7 0.3 1.3
Lupus 2.8 4.2 4.9 -1.9 2.2
Neuroticism (2016) 1.6 2.3 3.5 1.9 -1.1
Primary Biliary Cirrhosis 0.5 0.7 0.7 0.9 -0.8
Rheumatoid Arthritis 0.9 1.3 2.5 1.6 0.1
Schizophrenia (2014) 0.1 0.2 0.4 -0.2 0.7
Triglycerides 0.0 0.0 0.0 -0.1 0.1
Type 2 Diabetes (T2D) (2012) 1.8 2.1 3.5 -1.9 0.8
Ulcerative Colitis 1.1 1.6 2.7 -1.6 0.7
Blood Eosinophil Count 7.2 55.7 71.5 -6.3 8.5
Blood Platelet Count 2.8 32.8 65.4 -8.1 0.4
Blood Red Count 0.6 6.2 8.0 2.1 -2.8
Blood White Count 0.9 6.8 8.6 -2.2 2.9
Heel T-Score 0.1 0.6 1.1 0.0 1.1
BMI 0.2 1.0 1.2 -0.9 1.1
Height 0.1 2.7 4.5 -2.1 -0.9
Waist Hip Ratio (WHR) 0.3 1.2 2.4 1.6 0.1
Systolic Blood Pressure 3.2 15.9 21.4 4.6 -3.2
Smoking Status 0.7 1.6 1.6 1.3 -1.3
Allergy or Eczema 2.2 5.8 11.4 -0.5 3.4
Cardiovascular Disease 0.5 1.7 2.3 1.1 1.5
Hypothyroidism (self reported) 2.3 5.3 7.9 -1.7 2.8
Respiratory disease 4.3 9.6 14.2 -2.2 3.8
Type 2 Diabetes (T2D) (2018) 0.5 1.0 1.9 -0.3 1.4
Lung FEV1/FVC ratio 0.8 3.8 5.3 -2.3 1.5
Lung FVC 0.7 3.5 4.9 1.5 -2.2
Neuroticism 0.5 1.1 1.5 0.9 -1.2
Chronotype (morning person) 0.0 0.1 0.1 -0.1 -0.4
Hair Pigment 0.1 1.9 2.3 -1.2 1.5
Tanning 0.1 1.1 1.9 -1.4 0.5
Hand grip strength (left) 0.1 0.2 0.4 -0.6 0.1
Number of treatments/medications taken 1.8 3.3 6.5 -0.4 2.5
Average weekly spirits intake 1.5 1.9 2.5 -1.6 1.1
Sensitivity / hurt feelings 0.6 1.0 2.0 -0.2 1.4
Frequency of depressed mood in last 2 weeks 1.6 2.2 2.7 1.3 -1.7
Hearing difficulty/problems: Yes 1.6 2.5 3.0 -1.7 1.4
Relative age of first facial hair 0.9 1.9 2.8 -1.7 1.0
Other serious medical condition/disability diagnosed by doctor 2.8 3.6 4.1 -1.8 2.0
Ever used hormone-replacement therapy (HRT) 1.9 2.4 3.5 -1.1 1.9
Ever had hysterectomy (womb removed) 0.0 0.0 0.0 -0.1 0.1
Systolic blood pressure, automated reading 1.2 3.6 4.4 2.1 -1.7
Eye problems/disorders: Diabetes related eye disease 1.5 1.6 2.0 -1.1 1.4
Angina 5.7 7.5 11.6 -1.8 3.4
Medication for hormone replacement therapy 1.0 1.1 2.0 -0.4 1.4
Vitamin and mineral supplements 0.2 0.2 0.4 -0.7 0.1
Supplements: Zinc 0.7 0.7 1.1 -0.6 -1.0
Medication: Co-codamol 0.3 0.3 0.6 -0.8 0.0
Medication: Metformin 0.7 1.1 1.2 -1.0 1.1
Diabetes (father) 0.1 0.1 0.1 -0.3 0.2
Diabetes (mother) 0.2 0.2 0.3 -0.4 -0.5
Severe depression (siblings) 0.7 0.8 1.6 -1.3 0.1
Pack years adult smoking proportion 5.6 8.6 8.6 -2.9 2.9
Impedance of leg (right) 0.1 0.4 0.7 -0.8 0.2
Leg fat-free mass (left) 0.1 0.4 0.7 -0.9 0.0
Trunk fat percentage 0.6 2.3 3.9 -2.0 0.8
Hand grip strength (right) 0.4 1.0 1.9 0.4 -1.4
Townsend deprivation index at recruitment 0.4 0.6 1.1 -1.0 -0.2
Current tobacco smoking 1.0 1.7 2.9 0.7 -1.7
Average weekly fortified wine intake 0.1 0.1 0.1 -0.3 0.3
Maternal smoking around birth 0.2 0.3 0.5 -0.7 -0.2
Fed-up feelings 0.4 0.8 1.6 -0.2 1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.1 1.6 0.8 -1.3
Relative age voice broke 2.6 4.0 4.1 -2.0 2.0
Taking other prescription medications 1.3 1.9 3.6 -0.5 1.9
Age when periods started (menarche) 1.0 2.4 2.9 -1.7 1.4
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.1 -0.1 1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.0 0.0 0.1 0.1 0.2
Tinnitus: Yes, but not now, but have in the past 4.4 4.7 5.8 -1.9 2.4
Qualifications: CSEs or equivalent 0.5 0.6 1.0 1.0 -0.6
Serious illness, injury or assault to yourself 0.8 1.0 1.5 -1.2 0.7
High blood pressure 0.6 1.6 3.3 0.1 1.8
Hayfever, allergic rhinitis or eczema 1.5 3.3 6.4 -0.4 2.5
Multivitamins +/- minerals 0.2 0.3 0.5 0.7 -0.1
Stomach or abdominal pain in last month 0.2 0.3 0.4 0.6 0.4
Supplements: Glucosamine 0.2 0.3 0.6 0.8 0.2
Diverticular disease/diverticulitis (self-reported) 0.1 0.2 0.3 -0.6 -0.2
Medication: Atenolol 4.3 5.4 5.8 -2.2 2.4
Medication: Levothyroxine sodium 0.2 0.4 0.8 -0.2 0.9
Sitting height 0.1 0.6 1.2 0.1 -1.1
Chronic bronchitis/emphysema (father) 1.3 1.6 2.2 -1.5 1.0
High blood pressure (mother) 2.6 3.7 4.8 2.2 -1.6
Body mass index (BMI) 0.0 0.1 0.1 -0.3 0.3
Impedance of leg (left) 0.1 0.3 0.6 -0.8 0.1
Leg predicted mass (left) 0.1 0.3 0.6 -0.8 -0.0
Trunk fat mass 0.5 2.1 3.5 -1.9 0.8
Waist circumference 0.2 0.8 1.0 -1.0 0.8
Number of incorrect matches in round 2.2 3.7 5.9 1.2 -2.4
Past tobacco smoking 0.5 0.9 1.5 -1.2 0.6
Alcohol usually taken with meals 0.9 1.5 1.5 -1.2 1.2
Nervous feelings 0.0 0.1 0.1 0.2 0.3
Frequency of tenseness / restlessness in last 2 weeks 1.1 1.7 2.7 0.9 -1.6
Hearing difficulty/problems with background noise 0.3 0.5 0.8 -0.4 0.9
Hair/balding pattern: Pattern 2 0.2 0.3 0.4 -0.3 0.6
Had menopause 0.2 0.2 0.3 -0.3 0.6
Had other major operations 1.4 1.7 3.1 -0.7 1.8
Forced vital capacity (FVC) 0.3 1.1 1.4 0.9 -1.2
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 0.7 0.8 0.2
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.3 -1.1 -0.1
Qualifications: None of the above 0.6 1.2 2.4 0.2 1.5
Financial difficulties in last 2 years 0.2 0.3 0.4 -0.7 -0.3
Mouth/teeth dental problems 0.4 0.7 1.0 -0.6 -1.0
Heart attack 6.4 8.2 8.5 -2.8 2.9
Allergy 5.1 11.7 19.4 2.0 -4.4
Pain all over the body in last month 0.2 0.3 0.5 -0.1 0.7
Diabetes (self-reported) 1.1 1.7 3.0 -0.7 1.7
Hayfever/allergic rhinitis (self-reported) 1.1 1.4 2.3 -0.7 1.5
Medication: Ramipril 0.3 0.4 0.5 -0.4 0.7
Medication: Simvastatin 1.3 1.9 2.4 -1.2 1.5
Fluid intelligence score 0.1 0.2 0.2 -0.4 0.5
Illnesses of siblings 4.2 5.9 8.2 1.9 -2.9
Neuroticism score 0.2 0.4 0.4 0.5 -0.7
Weight 0.2 0.8 1.2 -1.1 0.5
Impedance of arm (right) 0.1 0.7 1.1 -1.1 -0.5
Arm fat percentage (right) 0.2 0.8 1.3 -1.1 0.6
Trunk fat-free mass 0.0 0.1 0.1 -0.3 0.2
Hip circumference 0.5 2.2 3.6 -1.9 0.8
Time employed in main current job 0.6 0.7 0.9 0.9 -0.8
Alcohol intake versus 10 years previously 0.5 0.7 0.8 0.7 -0.9
Father’s age at death 0.1 0.2 0.3 -0.6 0.3
Worrier / anxious feelings 0.4 0.7 1.0 1.0 -0.7
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.2 0.0 -0.4
Falls in the last year 0.2 0.3 0.4 0.5 0.6
Hair/balding pattern: Pattern 3 0.6 0.9 1.0 -1.0 0.9
Number of live births 0.3 0.4 0.4 -0.6 0.6
Forced expiratory volume in 1-second (FEV1) 0.2 0.5 0.8 0.5 -0.9
Pulse rate 0.5 0.8 1.4 1.2 0.5
Happiness 0.2 0.2 0.4 0.2 -0.6
Noisy workplace 0.5 0.6 0.9 0.6 -0.9
Qualifications: A levels/AS levels or equivalent 0.0 0.1 0.1 -0.3 -0.3
Serious illness, injury or assault of a close relative in last 2 years 1.3 1.5 2.1 -0.9 1.4
Mouth/teeth dental problems: Dentures 0.6 1.1 2.2 1.5 0.1
Asthma 4.3 8.5 11.0 -2.4 3.3
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.2 0.5 0.7 0.0
Medication: Cholesterol lowering 0.1 0.2 0.3 0.6 0.0
Depression (self-reported) 6.5 7.8 8.1 2.8 -2.8
Medication: Lansoprazole 0.1 0.1 0.3 0.5 -0.0
Prospective memory result 0.4 0.5 0.8 0.9 -0.4
Lung cancer (father) 0.2 0.2 0.4 -0.6 0.3
Illnesses of mother 0.0 0.1 0.1 -0.3 0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.5 0.7 0.5 -0.9
Pulse wave Arterial Stiffness index 2.5 2.9 4.8 2.2 -1.0
Impedance of arm (left) 0.1 0.5 0.7 -0.8 -0.5
Arm fat mass (right) 0.1 0.4 0.7 -0.8 0.3
Trunk predicted mass 0.0 0.1 0.1 -0.3 0.2
Standing height 0.1 1.4 2.7 -1.6 0.2
Length of working week for main job 0.5 0.5 0.9 0.4 -1.0
Exposure to tobacco smoke at home 0.2 0.2 0.4 0.0 0.6
Breastfed as a baby 0.3 0.4 0.7 -0.8 -0.0
Tense / ‘highly strung’ 2.3 3.7 4.4 2.1 -1.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.0 0.1 0.1 0.1 -0.3
Hair/balding pattern: Pattern 4 0.3 0.6 1.2 0.2 1.1
Birth weight of first child 1.7 3.0 5.6 -2.4 0.7
Peak expiratory flow (PEF) 0.1 0.3 0.5 -0.1 -0.7
Pulse wave reflection index 0.8 1.0 1.6 0.6 -1.3
Ever highly irritable/argumentative for 2 days 0.9 1.0 1.1 1.0 -1.0
Loud music exposure frequency 1.5 1.6 3.2 -1.8 0.1
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 0.9 1.0 -0.6
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 1.0 -1.0 0.6
Blood clot in the leg (DVT) 2.1 2.8 3.5 -1.4 1.9
Medication: Paracetamol 0.9 1.5 2.0 -1.0 1.4
Headache pain in last month 0.9 1.5 2.9 -0.3 1.7
Medication for cholesterol, blood pressure or diabetes 0.6 0.9 1.5 -1.2 0.6
Glaucoma (self-reported) 1.7 2.0 3.0 1.0 -1.7
Gout (self-reported) 0.3 0.4 0.5 -0.7 -0.6
Hypothyroidism/myxoedema (self-reported) 1.8 3.5 6.2 -0.9 2.5
Medication: Amlodipine 0.1 0.2 0.4 0.6 -0.1
Medication: Ventolin 100micrograms inhaler 3.1 4.0 5.8 -1.4 2.4
Birth weight 0.5 1.2 2.3 -1.5 0.2
Chronic bronchitis/emphysema (mother) 0.9 1.1 1.4 -0.9 1.2
High blood pressure (siblings) 5.4 7.8 8.6 -2.6 2.9
Forced vital capacity (FVC), Best measure 0.2 0.8 0.9 0.9 -0.9
Body fat percentage 0.5 1.8 2.9 -1.7 0.8
Leg fat percentage (right) 0.3 1.1 1.1 -1.0 1.0
Arm fat-free mass (right) 0.1 0.3 0.4 -0.6 0.4
Exposure to tobacco smoke outside home 0.2 0.2 0.4 0.3 0.7
Comparative body size at age 10 0.6 1.6 3.2 0.3 -1.8
Number of full brothers 0.5 0.6 1.1 -0.4 1.1
Worry too long after embarrassment 0.7 1.1 1.4 1.2 -0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.0 0.0 0.1 -0.3 0.0
Wheeze or whistling in the chest in last year 3.3 6.0 8.3 -1.9 2.9
Number of children fathered 0.6 0.6 1.2 1.1 -0.2
Reason for reducing amount of alcohol drunk: Health precaution 3.6 4.2 5.1 2.3 -1.8
Age at first live birth 0.0 0.0 0.1 0.0 -0.3
Pulse wave peak to peak time 3.0 3.5 5.9 -2.4 1.0
Health satisfaction 0.5 0.6 1.2 1.1 -0.3
Shortness of breath walking on level ground 0.3 0.4 0.7 0.2 0.8
Qualifications: College or University degree 0.2 0.6 0.6 -0.8 -0.7
Eye problems/disorders: None of the above 0.9 1.0 1.4 0.7 -1.2
Mouth/teeth dental problems: Loose teeth 2.5 2.9 3.3 -1.8 1.6
Emphysema/chronic bronchitis 5.2 5.9 8.9 -1.7 3.0
Medication for pain relief, constipation, heartburn 1.2 2.0 4.0 0.3 -2.0
Neck or shoulder pain in last month 0.3 0.5 0.9 1.0 -0.1
Medication: Blood pressure 0.7 1.2 2.0 1.4 -0.7
Angina (self-reported) 6.0 7.9 12.3 -1.9 3.5
Migraine (self-reported) 0.3 0.4 0.7 -0.9 -0.0
Medication: Ibuprofen 0.4 0.5 0.9 0.9 -0.4
Medication: Allopurinol 1.4 1.8 3.5 0.5 -1.9
Medication: Omeprazole 0.2 0.3 0.6 0.2 0.7
Medication: Seretide 50 evohaler 0.5 0.6 1.1 -0.1 1.1
Mean time to correctly identify matches 0.2 0.4 0.7 0.9 -0.1
Heart disease (mother) 0.5 0.6 1.1 -1.0 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.0 1.0 -0.5
Whole body fat mass 0.4 1.5 2.5 -1.6 0.7
Leg fat mass (right) 0.2 0.7 1.0 -1.0 0.6
Arm predicted mass (right) 0.1 0.3 0.5 -0.7 0.3
Pulse rate, automated reading 0.3 1.1 2.2 -0.1 1.5
Alcohol intake frequency. 0.3 0.7 0.9 -1.0 0.7
Comparative height size at age 10 0.6 3.1 4.5 1.3 -2.1
Number of full sisters 0.2 0.3 0.5 0.3 -0.7
Suffer from ‘nerves’ 2.3 3.6 4.3 2.1 -1.7
Overall health rating 0.4 0.8 1.2 -0.6 1.1
Chest pain or discomfort 2.4 3.5 4.0 -1.7 2.0
Had major operations 0.7 0.8 1.7 0.0 1.3
Age at last live birth 0.1 0.2 0.4 0.0 -0.7
Family relationship satisfaction 0.1 0.2 0.3 0.1 0.6
Leg pain on walking 0.1 0.1 0.1 0.2 0.3
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.4 -0.1 0.6
Commuting to job workplace: Car/motor vehicle 1.2 1.3 2.5 -1.6 0.3
Illness, injury, bereavement, stress in last 2 years 0.9 1.1 1.2 1.0 -1.1
Medication: Aspirin 1.5 2.0 4.0 0.1 2.0
Supplements: Vitamin C 0.5 0.6 1.2 0.2 -1.1
Knee pain experienced in last month 0.1 0.1 0.2 0.2 0.4
Hypertension (Self-reported) 0.6 1.7 3.3 0.2 1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 4.0 4.7 7.4 2.7 -1.4
Illnesses of father: Heart disease 0.9 1.3 2.5 0.0 1.6
Illnesses of siblings: Diabetes 2.8 3.4 4.5 -1.5 2.1
Smoking status: Previous 0.1 0.1 0.1 0.4 0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.2 2.4 0.1 -1.5
Whole body fat-free mass 0.0 0.2 0.3 -0.6 0.2
Leg fat-free mass (right) 0.0 0.2 0.4 -0.6 -0.1
Arm fat percentage (left) 0.2 0.6 1.1 -1.0 0.4
Average weekly red wine intake 0.0 0.0 0.1 0.2 -0.1
Handedness (chirality/laterality): Left-handed 0.8 0.9 1.0 -0.9 1.0
Mood swings 0.1 0.2 0.3 -0.1 -0.6
Loneliness, isolation 0.4 0.5 0.9 -0.3 1.0
Long-standing illness, disability or infirmity 3.6 5.5 7.8 -1.8 2.8
Ever had bowel cancer screening 0.5 0.6 0.9 -1.0 0.5
Diabetes diagnosed by doctor 0.7 1.2 2.2 -0.5 1.5
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.6 0.7 0.6 -0.8
Friendships satisfaction 0.3 0.4 0.7 0.9 -0.3
Qualifications: nursing, teaching 0.8 1.3 2.4 0.3 -1.6
Commuting to job workplace: Walk 4.4 4.7 5.1 -2.3 2.1
Eye problems/disorders: Cataract 1.8 2.1 2.5 -1.3 1.6
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 1.1 1.1 -0.0
Medication for cholesterol 5.3 8.0 11.7 2.1 -3.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.7 2.0 3.1 1.8 -1.0
Back pain experienced in last month 1.1 1.6 3.1 1.7 0.3
Mineral and other dietary supplements 1.0 1.4 2.0 -1.4 0.8
Breast cancer (self-reported) 0.2 0.2 0.4 -0.6 -0.1
Asthma (self-reported) 3.5 6.9 8.6 -2.3 2.9
Osteoporosis (self-reported) 0.5 0.7 1.1 0.5 -1.0
Osteoarthritis (self-reported) 0.7 0.9 1.2 -1.1 0.8
Medication: Aspirin 1.2 1.5 2.9 0.4 1.7
Medication: Gliclazide 0.5 0.6 1.1 1.0 0.1
Illnesses of father: None of the above (group 1) 1.0 1.2 2.3 -0.2 -1.5
Smoking status: Current 2.2 3.5 4.9 1.5 -2.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.1 4.5 6.3 2.5 -1.6
Whole body water mass 0.0 0.2 0.3 -0.6 0.2
Leg predicted mass (right) 0.0 0.2 0.4 -0.6 -0.1
Arm fat mass (left) 0.1 0.4 0.7 -0.8 0.3
Number of self-reported non-cancer illnesses 3.1 5.4 7.0 -1.9 2.7
Average weekly champagne plus white wine intake 0.5 0.7 1.2 -0.5 1.1
Miserableness 0.4 0.7 1.2 -1.1 0.4
Guilty feelings 0.4 0.5 1.1 -0.0 -1.0
Wears glasses or contact lenses 1.2 1.4 1.5 -1.2 1.1
Ever taken oral contraceptive pill 0.1 0.1 0.1 0.1 0.4
Hearing aid user 4.7 5.3 6.3 -2.1 2.5
Mother’s age at death 0.1 0.2 0.2 -0.4 0.5
Financial situation satisfaction 0.1 0.1 0.2 0.4 -0.1
Tinnitus: Yes, now most or all of the time 1.6 1.9 3.3 -0.8 1.8
Commuting to job workplace: Public transport 1.6 1.9 3.2 1.8 -0.8
Eye problems/disorders: Glaucoma 1.0 1.2 2.3 0.3 -1.5
Medication: Blood pressure 4.4 8.5 10.1 -2.6 3.2
Pain type(s) experienced in last month: Hip pain 0.3 0.4 0.5 0.7 0.4
Supplements: Fish oil (including cod liver oil) 0.4 0.5 0.9 0.9 -0.4
High cholesterol (Self-reported) 0.2 0.4 0.8 0.2 0.9
Medication: Bendroflumethiazide 1.2 1.8 2.1 -1.5 1.2
Medication: Paracetamol 0.0 0.1 0.1 -0.2 0.2
Medication: Lisinopril 0.5 0.7 0.7 0.8 0.8
Medication: Atorvastatin 2.1 2.6 5.1 -0.5 2.2
Illnesses of father: High blood pressure 0.1 0.1 0.1 0.4 0.1
Alcohol drinker status: Never 0.4 0.5 0.6 -0.6 0.8
Ever smoked 0.4 0.7 0.8 0.8 -0.9
Basal metabolic rate 0.1 0.3 0.5 -0.7 0.2
Leg fat percentage (left) 0.3 1.0 1.0 -1.0 1.0
Arm fat-free mass (left) 0.1 0.3 0.4 -0.6 0.4
Number of operations (self-reported) 3.5 5.1 8.9 -1.2 3.0
Average weekly beer plus cider intake 0.7 1.0 2.0 1.4 -0.1
Irritability 1.1 1.8 3.4 0.5 -1.8
Risk taking 1.2 1.8 2.9 1.7 -0.9
Ever had prostate specific antigen (PSA) test 0.4 0.5 0.7 0.5 -0.8
Fractured/broken bones in last 5 years 0.2 0.2 0.4 -0.1 -0.6
Age started oral contraceptive pill 0.5 0.7 1.1 -0.5 1.1
Diastolic blood pressure, automated reading 1.9 5.9 6.1 2.4 -2.5
Ever depressed for a whole week 1.4 1.7 2.9 -1.7 0.7
Unable to work because of sickness or disability 1.4 1.8 2.4 -1.6 1.1
Commuting to job workplace: Cycle 0.6 0.7 1.3 -0.3 1.2
Myopia 3.9 5.6 10.1 1.1 -3.2
Vascular/heart problems diagnosed by doctor 1.2 3.3 6.3 0.5 -2.5
Cholesterol lowering medication 2.6 3.9 6.0 -1.3 2.4
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.0 0.0 1.0
Pain experienced in last month 0.5 0.8 1.2 -1.1 -0.6
Supplements: Calcium 0.1 0.1 0.1 0.4 -0.3
Basal cell carcinoma (self-reported) 0.7 0.8 1.5 -0.2 1.2
Heart attack/myocardial infarction (self-reported) 6.0 7.8 8.2 -2.7 2.9
Deep venous thrombosis (DVT) (self-reported) 1.6 2.1 2.6 -1.3 1.6
Heart disease (siblings) 1.3 1.6 3.2 -0.3 1.8
Alcohol drinker status: Previous 0.2 0.2 0.5 0.1 0.7
Pack years of smoking 7.3 10.7 12.0 -3.1 3.5
Impedance of whole body 0.1 0.7 1.3 -1.1 -0.2
Leg fat mass (left) 0.2 0.6 1.0 -1.0 0.5
Arm predicted mass (left) 0.1 0.3 0.4 -0.6 0.3