Hub : Genes

SNRPD3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 NTR Blood 0.0237 0.0089 9.4e-04 0.016 0.010 0.013 0.013 0.014 4.9e-06 3.4e-04 2.9e-05 4.4e-05 1.3e-05
2 YFS Blood 0.0585 0.0148 1.2e-08 0.043 0.024 0.041 0.038 0.046 7.8e-14 2.0e-08 1.9e-13 1.8e-12 6.0e-15

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.8 1.3 1.7 -1.3 0.9
Bipolar Disorder or Schizophrenia 2.5 6.2 7.2 -2.7 2.3
Depressed Affect (Nagel 2018) 0.1 0.3 0.5 0.1 0.7
Depression (Nagel 2018) 0.2 0.3 0.3 -0.6 0.6
Intelligence (Savage-Jansen 2018) 0.3 0.8 1.6 0.1 -1.3
Neuroticism (Nagel 2018) 0.1 0.1 0.2 0.3 0.4
Schizophrenia (2018) 2.5 5.3 5.6 -2.4 2.2
Schizophrenia vs Biploar Disorder 1.4 1.9 3.2 -0.8 1.8
Worry (Nagel 2018) 0.1 0.1 0.1 0.4 0.3
Alzheimer’s Disease (in mother) 0.5 0.5 0.8 -0.9 0.5
Alzheimer’s Disease (in father) 1.2 1.3 1.7 0.9 -1.3
Alzheimer’s Disease (including proxy) 0.1 0.2 0.3 -0.5 -0.2
Crohns Disease (2017) 1.0 2.1 3.3 1.8 -1.0
Irritable Bowel Disease (IBD) 0.6 1.4 2.5 1.6 -0.6
Ulcerative Colitis (UC) 0.4 0.7 1.2 1.1 -0.4
Major Depression (MDD) 0.0 0.0 0.0 0.2 0.1
Reaction Time 0.0 0.1 0.1 0.3 0.1
Verbal and Numeric Reasoning (VNR) 0.1 0.2 0.2 -0.4 -0.5
Breast Cancer 1.0 2.4 2.5 -1.5 1.6
Ovarian Cancer 0.6 0.8 1.1 -0.7 1.1
Prostate Cancer 1.6 2.2 2.3 1.5 -1.5
Age at First Birth 0.7 1.0 1.4 -0.9 1.2
Bipolar Disorder (2011) 0.1 0.1 0.2 -0.2 0.4
Body Mass Index (BMI) (2010) 0.0 0.0 0.0 -0.1 0.1
Coronary Artery Disease (CAD) 0.9 1.0 1.5 1.2 -0.7
Crohns Disease (2012) 1.8 3.0 3.8 2.0 -1.5
Mean Putamen Volume 0.9 1.0 1.7 -1.3 0.6
Fasting Glucose 0.1 0.1 0.2 0.3 -0.4
HbA1C 2.3 2.6 2.8 1.7 -1.5
HDL Cholesterol 0.1 0.2 0.3 -0.6 0.3
LDL Cholesterol 0.1 0.2 0.3 0.6 -0.3
Lupus 0.4 0.5 1.1 -1.0 0.1
Neuroticism (2016) 1.1 1.7 1.7 -1.3 1.3
Primary Biliary Cirrhosis 0.7 1.0 1.1 1.1 -0.9
Rheumatoid Arthritis 1.7 2.3 3.5 1.9 -1.0
Schizophrenia (2014) 2.7 6.1 6.3 -2.5 2.4
Triglycerides 0.8 1.3 2.0 -0.8 1.4
Type 2 Diabetes (T2D) (2012) 0.5 0.6 0.6 -0.8 0.8
Ulcerative Colitis 0.1 0.1 0.2 0.1 0.5
Blood Eosinophil Count 2.1 15.9 27.5 5.2 -2.1
Blood Platelet Count 0.3 3.3 3.7 -1.9 1.7
Blood Red Count 0.0 0.5 0.9 -0.9 -0.2
Blood White Count 0.3 2.4 4.0 2.0 0.9
Heel T-Score 0.1 0.4 0.7 -0.8 -0.3
BMI 0.1 0.5 0.7 -0.9 0.5
Height 0.0 0.2 0.3 0.3 0.5
Waist Hip Ratio (WHR) 0.2 0.7 1.2 0.5 -1.1
Systolic Blood Pressure 0.1 0.7 1.3 -1.1 0.4
Smoking Status 0.2 0.4 0.7 -0.8 0.3
Allergy or Eczema 0.2 0.7 1.1 -0.5 1.0
Cardiovascular Disease 0.0 0.1 0.2 0.5 -0.3
Hypothyroidism (self reported) 1.0 2.4 2.9 -1.4 1.7
Respiratory disease 1.1 2.4 3.1 1.8 -1.3
Type 2 Diabetes (T2D) (2018) 0.0 0.1 0.1 0.2 0.3
Lung FEV1/FVC ratio 0.2 0.8 1.4 -0.4 1.2
Lung FVC 0.7 3.4 5.2 -2.3 1.2
Neuroticism 0.0 0.1 0.2 0.4 0.2
Chronotype (morning person) 0.7 1.7 2.2 1.5 -1.1
Hair Pigment 0.0 0.3 0.6 0.8 -0.2
Tanning 0.0 0.1 0.1 -0.3 0.2
Hand grip strength (left) 0.9 2.5 3.5 -1.9 1.2
Number of treatments/medications taken 0.5 0.9 0.9 -1.0 1.0
Average weekly spirits intake 0.0 0.0 0.1 0.3 -0.0
Sensitivity / hurt feelings 0.4 0.7 1.2 1.1 -0.4
Frequency of depressed mood in last 2 weeks 0.1 0.2 0.3 -0.2 0.6
Hearing difficulty/problems: Yes 1.9 3.0 3.8 1.4 -2.0
Relative age of first facial hair 0.3 0.6 1.0 0.4 -1.0
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 0.6 -0.6 0.8
Ever used hormone-replacement therapy (HRT) 0.3 0.4 0.7 0.8 -0.2
Ever had hysterectomy (womb removed) 0.1 0.1 0.2 0.5 -0.1
Systolic blood pressure, automated reading 0.1 0.2 0.5 -0.1 -0.7
Eye problems/disorders: Diabetes related eye disease 0.0 0.0 0.0 0.1 0.1
Angina 0.2 0.2 0.4 -0.7 -0.0
Medication for hormone replacement therapy 0.2 0.2 0.3 0.6 -0.3
Vitamin and mineral supplements 0.7 1.0 1.8 1.4 -0.4
Supplements: Zinc 0.1 0.1 0.2 -0.1 -0.5
Medication: Co-codamol 0.7 0.8 0.8 -0.9 0.8
Medication: Metformin 0.2 0.3 0.5 -0.4 0.7
Diabetes (father) 1.3 1.6 1.8 -1.2 1.4
Diabetes (mother) 0.2 0.3 0.5 -0.3 0.7
Severe depression (siblings) 0.9 1.0 1.2 -1.1 0.9
Pack years adult smoking proportion 1.3 1.9 2.2 1.3 -1.5
Impedance of leg (right) 0.0 0.2 0.3 -0.5 0.1
Leg fat-free mass (left) 0.0 0.2 0.4 -0.2 0.7
Trunk fat percentage 0.2 0.7 0.8 -0.9 0.8
Hand grip strength (right) 0.6 1.6 2.2 -1.5 1.0
Townsend deprivation index at recruitment 0.2 0.3 0.4 0.4 -0.7
Current tobacco smoking 1.0 1.7 1.8 1.3 -1.3
Average weekly fortified wine intake 0.5 0.6 0.8 -0.7 0.9
Maternal smoking around birth 0.1 0.1 0.2 -0.4 0.3
Fed-up feelings 0.1 0.1 0.2 0.4 0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.3 -0.6 -0.5
Relative age voice broke 0.4 0.7 0.8 0.8 -0.9
Taking other prescription medications 0.3 0.4 0.5 -0.6 0.7
Age when periods started (menarche) 1.9 4.7 4.7 -2.2 2.2
Bilateral oophorectomy (both ovaries removed) 0.0 0.0 0.0 -0.2 0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.2 1.9 0.8 -1.4
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.6 0.3 -0.8
Qualifications: CSEs or equivalent 0.0 0.0 0.0 0.1 -0.2
Serious illness, injury or assault to yourself 0.1 0.1 0.1 0.1 -0.4
High blood pressure 0.2 0.5 0.8 -0.5 0.9
Hayfever, allergic rhinitis or eczema 0.0 0.1 0.1 0.0 0.4
Multivitamins +/- minerals 1.6 2.0 2.9 -1.7 1.1
Stomach or abdominal pain in last month 0.1 0.2 0.3 0.6 0.1
Supplements: Glucosamine 0.5 0.6 1.0 -1.0 0.5
Diverticular disease/diverticulitis (self-reported) 0.9 1.0 1.2 1.1 -0.9
Medication: Atenolol 0.0 0.0 0.0 0.0 -0.0
Medication: Levothyroxine sodium 0.5 0.8 1.3 -0.5 1.2
Sitting height 0.4 2.5 4.1 2.0 -1.0
Chronic bronchitis/emphysema (father) 1.5 1.8 2.3 -1.5 1.1
High blood pressure (mother) 0.3 0.4 0.7 -0.9 0.2
Body mass index (BMI) 0.3 1.5 1.7 -1.3 1.1
Impedance of leg (left) 0.0 0.2 0.3 -0.5 -0.2
Leg predicted mass (left) 0.0 0.2 0.4 -0.2 0.7
Trunk fat mass 0.3 1.1 1.1 -1.0 1.0
Waist circumference 0.4 1.5 1.6 -1.2 1.2
Number of incorrect matches in round 0.0 0.0 0.0 -0.2 0.2
Past tobacco smoking 0.7 1.3 1.9 1.4 -0.9
Alcohol usually taken with meals 0.1 0.1 0.1 -0.2 0.4
Nervous feelings 0.1 0.1 0.3 0.5 -0.0
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.1 0.2 0.1 0.4
Hearing difficulty/problems with background noise 0.9 1.4 1.7 1.3 -1.1
Hair/balding pattern: Pattern 2 0.5 0.6 0.9 0.9 -0.6
Had menopause 1.0 1.2 1.4 1.2 -1.0
Had other major operations 4.2 5.1 5.8 -2.4 2.1
Forced vital capacity (FVC) 0.1 0.6 0.7 -0.8 0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 0.6 0.4 -0.8
Ever unenthusiastic/disinterested for a whole week 2.6 3.2 3.9 -2.0 1.6
Qualifications: None of the above 2.4 5.0 7.1 2.7 -1.7
Financial difficulties in last 2 years 0.1 0.2 0.4 0.0 -0.6
Mouth/teeth dental problems 0.2 0.3 0.3 0.5 0.5
Heart attack 1.2 1.6 2.0 -1.4 1.0
Allergy 0.1 0.2 0.5 -0.7 -0.1
Pain all over the body in last month 1.5 1.6 1.9 1.4 -1.2
Diabetes (self-reported) 0.1 0.2 0.3 -0.4 0.6
Hayfever/allergic rhinitis (self-reported) 0.8 1.0 1.1 -1.1 1.0
Medication: Ramipril 3.7 4.7 4.9 -2.2 2.1
Medication: Simvastatin 0.0 0.0 0.0 0.2 0.0
Fluid intelligence score 0.0 0.1 0.2 -0.0 -0.4
Illnesses of siblings 0.7 1.0 1.3 -0.8 1.1
Neuroticism score 0.1 0.1 0.2 0.4 0.3
Weight 0.1 0.7 0.8 -0.8 0.9
Impedance of arm (right) 0.1 0.6 1.1 1.1 -0.1
Arm fat percentage (right) 0.3 1.1 1.5 -0.9 1.2
Trunk fat-free mass 0.1 0.6 0.9 -0.6 0.9
Hip circumference 0.4 1.8 2.1 -1.2 1.4
Time employed in main current job 0.2 0.3 0.5 -0.7 -0.1
Alcohol intake versus 10 years previously 0.8 1.1 1.5 0.9 -1.2
Father’s age at death 0.0 0.0 0.1 0.1 -0.2
Worrier / anxious feelings 0.2 0.4 0.7 0.8 -0.2
Frequency of tiredness / lethargy in last 2 weeks 0.0 0.0 0.1 0.0 0.3
Falls in the last year 1.2 1.6 2.6 0.8 -1.6
Hair/balding pattern: Pattern 3 0.1 0.1 0.2 -0.4 0.1
Number of live births 0.0 0.1 0.1 -0.3 0.1
Forced expiratory volume in 1-second (FEV1) 0.1 0.5 0.5 -0.7 0.6
Pulse rate 1.4 2.4 2.6 1.5 -1.6
Happiness 0.0 0.0 0.1 0.2 -0.2
Noisy workplace 0.0 0.0 0.1 -0.1 -0.2
Qualifications: A levels/AS levels or equivalent 0.9 1.9 2.7 1.1 -1.6
Serious illness, injury or assault of a close relative in last 2 years 0.0 0.0 0.0 0.2 -0.2
Mouth/teeth dental problems: Dentures 0.1 0.2 0.3 -0.5 0.2
Asthma 0.2 0.4 0.7 0.8 -0.4
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.7 0.9 1.0 -0.8
Medication: Cholesterol lowering 0.1 0.2 0.3 -0.6 0.1
Depression (self-reported) 0.5 0.6 0.6 -0.7 0.8
Medication: Lansoprazole 0.1 0.1 0.2 -0.2 0.5
Prospective memory result 0.8 1.0 1.8 1.3 -0.5
Lung cancer (father) 2.2 2.6 3.1 1.8 -1.4
Illnesses of mother 1.9 2.3 3.2 1.8 -1.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 1.9 2.2 -1.5 1.3
Pulse wave Arterial Stiffness index 0.1 0.1 0.2 0.5 0.0
Impedance of arm (left) 0.2 0.9 1.3 1.2 -0.7
Arm fat mass (right) 0.4 1.5 1.9 -1.1 1.4
Trunk predicted mass 0.1 0.6 0.9 -0.6 1.0
Standing height 0.0 0.4 0.7 0.8 -0.2
Length of working week for main job 1.7 1.8 2.4 1.1 -1.6
Exposure to tobacco smoke at home 0.0 0.0 0.0 -0.0 0.1
Breastfed as a baby 0.9 1.2 1.5 1.2 -0.9
Tense / ‘highly strung’ 0.4 0.7 0.7 -0.8 0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 1.8 2.8 3.2 -1.8 1.5
Hair/balding pattern: Pattern 4 0.2 0.4 0.5 -0.7 0.6
Birth weight of first child 0.5 1.0 1.5 -0.6 1.2
Peak expiratory flow (PEF) 0.6 1.3 1.3 1.1 -1.2
Pulse wave reflection index 0.2 0.2 0.5 0.7 0.1
Ever highly irritable/argumentative for 2 days 1.1 1.3 1.7 0.9 -1.3
Loud music exposure frequency 6.4 7.0 7.0 2.6 -2.6
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 1.3 0.7 -1.1
Mouth/teeth dental problems: Bleeding gums 0.1 0.2 0.3 -0.6 0.1
Blood clot in the leg (DVT) 0.1 0.2 0.3 -0.1 0.6
Medication: Paracetamol 7.2 12.0 14.7 -3.0 3.8
Headache pain in last month 0.7 1.3 1.7 -0.9 1.3
Medication for cholesterol, blood pressure or diabetes 1.2 1.9 2.9 1.7 -1.0
Glaucoma (self-reported) 0.1 0.1 0.1 -0.3 0.3
Gout (self-reported) 1.2 1.7 2.3 1.5 -1.0
Hypothyroidism/myxoedema (self-reported) 1.8 3.6 4.0 -1.8 2.0
Medication: Amlodipine 0.0 0.0 0.0 0.2 -0.1
Medication: Ventolin 100micrograms inhaler 1.6 2.0 2.1 1.4 -1.4
Birth weight 0.5 1.1 1.3 0.9 -1.2
Chronic bronchitis/emphysema (mother) 0.9 1.0 1.4 -1.2 0.9
High blood pressure (siblings) 1.0 1.4 2.0 0.9 -1.4
Forced vital capacity (FVC), Best measure 0.4 1.5 1.9 -1.4 1.0
Body fat percentage 0.4 1.5 1.8 -1.3 1.1
Leg fat percentage (right) 0.6 2.1 2.9 -1.7 1.1
Arm fat-free mass (right) 0.3 1.4 1.6 -1.3 1.1
Exposure to tobacco smoke outside home 0.2 0.2 0.4 0.6 -0.3
Comparative body size at age 10 0.3 0.8 1.3 -1.1 0.5
Number of full brothers 0.8 1.0 1.7 0.7 -1.3
Worry too long after embarrassment 0.0 0.1 0.1 -0.3 0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 2.1 2.7 3.5 1.9 -1.4
Wheeze or whistling in the chest in last year 0.5 0.9 1.2 1.1 -0.8
Number of children fathered 0.0 0.0 0.1 0.3 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.8 0.9 1.1 0.9 -1.0
Age at first live birth 0.2 0.4 0.5 -0.7 0.6
Pulse wave peak to peak time 0.2 0.2 0.4 -0.6 0.1
Health satisfaction 0.1 0.1 0.2 0.0 -0.5
Shortness of breath walking on level ground 1.0 1.2 1.5 -0.9 1.2
Qualifications: College or University degree 1.1 3.6 5.0 -2.2 1.5
Eye problems/disorders: None of the above 0.0 0.0 0.0 0.2 0.0
Mouth/teeth dental problems: Loose teeth 1.5 1.7 2.1 -1.4 1.2
Emphysema/chronic bronchitis 0.1 0.1 0.2 -0.5 0.1
Medication for pain relief, constipation, heartburn 0.4 0.6 1.0 0.5 -1.0
Neck or shoulder pain in last month 3.7 5.3 6.2 -2.1 2.5
Medication: Blood pressure 0.9 1.5 2.3 -1.5 0.9
Angina (self-reported) 0.3 0.4 0.8 -0.9 0.3
Migraine (self-reported) 2.1 2.6 3.3 1.8 -1.4
Medication: Ibuprofen 0.1 0.1 0.1 0.2 -0.3
Medication: Allopurinol 1.6 2.1 3.1 1.8 -1.0
Medication: Omeprazole 0.3 0.4 0.6 0.3 -0.8
Medication: Seretide 50 evohaler 0.3 0.3 0.6 0.3 -0.8
Mean time to correctly identify matches 0.2 0.4 0.5 0.7 -0.5
Heart disease (mother) 0.5 0.6 0.8 -0.9 0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.5 0.7 0.8 -0.7
Whole body fat mass 0.4 1.5 1.5 -1.2 1.2
Leg fat mass (right) 0.4 1.7 2.1 -1.5 1.1
Arm predicted mass (right) 0.1 0.4 0.5 -0.7 0.6
Pulse rate, automated reading 0.3 1.0 1.2 0.8 -1.1
Alcohol intake frequency. 0.1 0.2 0.4 -0.1 0.6
Comparative height size at age 10 0.6 3.3 3.8 1.9 -1.7
Number of full sisters 0.0 0.0 0.1 -0.1 0.2
Suffer from ‘nerves’ 0.8 1.2 1.8 1.4 -0.8
Overall health rating 0.0 0.0 0.1 0.3 -0.0
Chest pain or discomfort 1.8 2.6 3.5 -1.9 1.3
Had major operations 0.3 0.4 0.8 0.9 -0.0
Age at last live birth 0.2 0.3 0.3 0.5 -0.5
Family relationship satisfaction 0.9 1.1 1.4 0.9 -1.2
Leg pain on walking 0.0 0.0 0.1 -0.3 0.1
Qualifications: NVQ or HND or HNC or equivalent 4.9 5.9 6.1 -2.5 2.4
Commuting to job workplace: Car/motor vehicle 6.7 7.7 8.5 2.6 -2.9
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.1 -0.2 0.3
Medication: Aspirin 0.2 0.2 0.4 -0.7 0.2
Supplements: Vitamin C 0.1 0.1 0.2 -0.2 -0.4
Knee pain experienced in last month 1.1 1.6 2.2 -1.5 1.0
Hypertension (Self-reported) 0.0 0.1 0.2 -0.1 0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.2 0.5 -0.1
Illnesses of father: Heart disease 0.4 0.6 0.8 -0.9 0.6
Illnesses of siblings: Diabetes 0.4 0.5 0.5 0.7 -0.7
Smoking status: Previous 1.4 2.0 2.4 -1.6 1.3
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.3 0.3 -0.5 0.5
Whole body fat-free mass 0.1 0.6 0.9 -0.6 0.9
Leg fat-free mass (right) 0.0 0.1 0.1 -0.0 0.3
Arm fat percentage (left) 0.2 0.8 0.9 -0.9 1.0
Average weekly red wine intake 0.4 0.6 0.7 -0.8 0.7
Handedness (chirality/laterality): Left-handed 1.7 2.0 2.6 -1.2 1.6
Mood swings 0.5 0.9 1.3 -0.7 1.1
Loneliness, isolation 0.2 0.3 0.5 0.7 -0.2
Long-standing illness, disability or infirmity 0.9 1.3 2.1 -0.8 1.4
Ever had bowel cancer screening 1.4 1.6 1.9 1.1 -1.4
Diabetes diagnosed by doctor 0.6 0.9 1.0 -1.0 1.0
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.2 0.1 -0.5
Friendships satisfaction 0.1 0.1 0.2 -0.4 -0.2
Qualifications: nursing, teaching 1.3 2.1 3.5 -1.9 0.8
Commuting to job workplace: Walk 1.7 1.9 2.1 -1.5 1.3
Eye problems/disorders: Cataract 1.2 1.4 2.1 -1.4 0.9
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 0.9 0.2 -1.0
Medication for cholesterol 0.2 0.3 0.5 -0.7 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.3 -0.2 0.6
Back pain experienced in last month 0.0 0.1 0.1 -0.1 0.4
Mineral and other dietary supplements 0.2 0.3 0.6 0.8 -0.1
Breast cancer (self-reported) 0.0 0.1 0.1 -0.2 -0.3
Asthma (self-reported) 0.7 1.4 2.0 1.4 -0.9
Osteoporosis (self-reported) 3.4 4.2 5.0 1.9 -2.2
Osteoarthritis (self-reported) 0.2 0.2 0.2 0.5 -0.5
Medication: Aspirin 0.3 0.5 0.8 -0.9 0.3
Medication: Gliclazide 0.1 0.1 0.2 -0.0 -0.4
Illnesses of father: None of the above (group 1) 1.0 1.2 1.7 1.3 -0.9
Smoking status: Current 0.4 0.6 0.6 0.8 -0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.2 1.6 -1.3 0.9
Whole body water mass 0.1 0.7 1.0 -0.6 1.0
Leg predicted mass (right) 0.0 0.1 0.2 -0.1 0.4
Arm fat mass (left) 0.2 0.8 1.0 -0.7 1.0
Number of self-reported non-cancer illnesses 0.2 0.3 0.5 -0.7 0.4
Average weekly champagne plus white wine intake 0.2 0.2 0.4 0.6 -0.3
Miserableness 0.5 0.9 1.4 1.2 -0.7
Guilty feelings 0.1 0.1 0.2 0.4 -0.1
Wears glasses or contact lenses 0.6 0.7 0.8 -0.7 0.9
Ever taken oral contraceptive pill 1.8 2.0 2.2 -1.3 1.5
Hearing aid user 0.0 0.0 0.0 0.2 -0.2
Mother’s age at death 0.1 0.2 0.3 -0.2 -0.5
Financial situation satisfaction 0.2 0.3 0.4 -0.6 0.4
Tinnitus: Yes, now most or all of the time 1.2 1.4 1.5 1.2 -1.2
Commuting to job workplace: Public transport 0.8 1.0 1.1 -1.1 0.9
Eye problems/disorders: Glaucoma 0.2 0.2 0.4 0.6 -0.3
Medication: Blood pressure 0.1 0.2 0.3 0.2 0.6
Pain type(s) experienced in last month: Hip pain 0.5 0.7 0.9 0.7 -1.0
Supplements: Fish oil (including cod liver oil) 0.2 0.2 0.4 -0.0 -0.7
High cholesterol (Self-reported) 0.4 0.7 0.9 -0.7 1.0
Medication: Bendroflumethiazide 0.6 0.9 1.5 -0.6 1.2
Medication: Paracetamol 7.7 12.0 14.2 -3.1 3.8
Medication: Lisinopril 0.0 0.0 0.0 -0.0 0.1
Medication: Atorvastatin 1.7 2.1 2.2 -1.5 1.4
Illnesses of father: High blood pressure 0.8 1.0 1.5 -1.2 0.7
Alcohol drinker status: Never 0.2 0.3 0.4 0.6 -0.4
Ever smoked 0.1 0.1 0.3 -0.5 0.1
Basal metabolic rate 0.1 0.6 0.8 -0.6 0.9
Leg fat percentage (left) 0.5 2.0 3.1 -1.8 1.0
Arm fat-free mass (left) 0.3 1.3 1.5 -1.1 1.2
Number of operations (self-reported) 0.7 1.1 1.6 -0.8 1.3
Average weekly beer plus cider intake 0.1 0.1 0.1 -0.3 0.4
Irritability 0.5 0.8 1.3 -1.1 0.5
Risk taking 0.1 0.1 0.2 0.1 -0.4
Ever had prostate specific antigen (PSA) test 0.4 0.4 0.5 0.7 -0.6
Fractured/broken bones in last 5 years 2.3 3.0 3.9 2.0 -1.5
Age started oral contraceptive pill 0.6 0.7 0.9 -0.8 0.9
Diastolic blood pressure, automated reading 0.9 2.9 3.8 1.4 -1.9
Ever depressed for a whole week 0.7 0.9 1.3 0.7 -1.1
Unable to work because of sickness or disability 0.5 0.6 0.9 0.9 -0.6
Commuting to job workplace: Cycle 0.0 0.1 0.1 -0.3 -0.1
Myopia 1.1 1.6 2.2 -1.5 1.0
Vascular/heart problems diagnosed by doctor 0.2 0.5 0.7 0.6 -0.8
Cholesterol lowering medication 0.4 0.6 1.2 -0.3 1.1
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.1 -0.3 0.2
Pain experienced in last month 1.0 1.6 2.6 0.7 -1.6
Supplements: Calcium 1.3 1.4 2.1 0.8 -1.4
Basal cell carcinoma (self-reported) 0.8 1.0 1.1 0.9 -1.0
Heart attack/myocardial infarction (self-reported) 1.0 1.2 1.6 -1.3 0.9
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.2 0.0 0.4
Heart disease (siblings) 0.3 0.4 0.6 -0.8 0.3
Alcohol drinker status: Previous 0.1 0.1 0.2 0.1 0.4
Pack years of smoking 1.5 2.1 2.5 1.3 -1.6
Impedance of whole body 0.0 0.2 0.2 0.4 -0.4
Leg fat mass (left) 0.4 1.5 2.0 -1.4 1.0
Arm predicted mass (left) 0.4 1.8 1.8 -1.3 1.3