TWAS hub - GGT5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Left Ventricle	0.0931	0.0384	7.4e-04	0.080	NA	0.068	NA	0.063	4.9e-05	NA	1.8e-04	NA	2.9e-04
2	TCGA	Breast Invasive Carcinoma	0.0607	0.0220	8.4e-11	0.049	0.054	0.051	NA	0.044	3.0e-10	3.2e-11	1.3e-10	NA	1.8e-09
3	TCGA	Cervical Squamous Cell Carcinoma	0.0930	0.0480	5.4e-03	0.028	0.050	0.042	NA	0.044	1.5e-02	1.7e-03	3.7e-03	NA	3.2e-03
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.0247	0.0139	3.8e-03	0.018	0.023	0.015	NA	0.010	3.5e-03	1.1e-03	7.5e-03	NA	2.1e-02
5	TCGA	Brain Lower Grade Glioma	0.0919	0.0332	2.4e-08	0.058	0.081	0.078	NA	0.069	3.4e-07	1.6e-09	3.8e-09	NA	2.5e-08
6	TCGA	Skin Cutaneous Melanoma	0.2340	0.1130	9.5e-03	0.024	0.038	0.038	NA	0.020	7.6e-02	3.4e-02	3.5e-02	NA	9.2e-02
7	TCGA	Thyroid Carcinoma	0.0630	0.0320	1.2e-03	0.008	0.016	0.023	NA	0.019	5.3e-02	1.0e-02	2.1e-03	NA	5.2e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Allergy or Eczema	5.5	14.4	21.1	2.6	4.6	4.1	4.0	3.9	3.4	3.6
Blood White Count	4.7	34.9	61.2	-0.5	6.2	7.1	5.9	7.0	3.2	7.8
Hayfever, allergic rhinitis or eczema	4.5	9.8	13.0	2.4	3.5	3.5	3.6	3.0	2.7	2.9
Mouth/teeth dental problems: Mouth ulcers	4.4	7.0	10.8	-1.1	-3.3	-2.8	-2.4	-2.8	-2.5	-3.0
Supplements: Glucosamine	4.3	5.6	8.2	-0.8	-2.9	-2.8	-2.3	-2.8	-2.1	-2.3
Medication: Aspirin	4.2	5.5	17.2	-1.5	-2.4	-2.4	-4.1	-2.0	0.1	-1.7
Hair/balding pattern: Pattern 2	4.0	5.0	7.8	0.2	2.5	2.6	2.1	2.8	1.8	2.5
Medication: Aspirin	4.0	5.3	15.7	-1.9	-2.4	-2.3	-4.0	-1.9	-0.1	-1.6
Allergy	3.9	8.9	16.1	-1.6	-3.1	-3.5	-4.0	-2.9	-1.9	-3.1
Average weekly fortified wine intake	3.8	4.4	6.1	1.7	2.5	2.3	1.6	2.4	2.4	1.7
Blood Eosinophil Count	3.6	27.9	58.8	-3.5	3.2	6.7	5.2	6.4	1.1	7.7
Medication: Blood pressure	3.6	6.8	9.2	1.3	2.8	3.0	1.6	3.0	3.0	2.9
Relative age of first facial hair	3.4	6.9	10.7	-2.6	-3.3	-2.3	-3.1	-2.5	-1.6	-2.7
Medication: Cholesterol lowering	3.4	5.3	10.5	-2.6	-2.4	-2.4	-3.2	-2.0	-1.1	-1.7
Myopia	3.4	4.9	7.1	-0.3	-2.5	-2.7	-2.1	-2.5	-1.9	-2.7
Medication for cholesterol	3.3	5.1	9.0	-0.9	-2.3	-2.4	-1.2	-2.6	-3.0	-2.4
Qualifications: nursing, teaching	3.2	4.9	9.9	0.6	-1.5	-3.1	-2.3	-2.5	-1.6	-2.7
Mother’s age at death	3.1	3.9	6.2	0.4	-1.9	-2.4	-1.8	-2.5	-1.4	-2.5
Rheumatoid Arthritis	3.0	4.1	8.9	-0.2	1.7	2.7	1.4	2.5	1.3	3.0
Pain experienced in last month	3.0	4.9	9.5	-1.4	-2.5	-2.4	-3.1	-2.2	-1.2	-2.1
Peak expiratory flow (PEF)	2.9	6.8	21.2	-4.6	-2.4	-1.7	-3.0	-2.0	-2.1	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.9	3.5	4.5	1.6	1.9	2.1	1.7	2.0	1.8	1.8
Verbal and Numeric Reasoning (VNR)	2.8	6.7	10.4	-0.6	-2.5	-3.2	-2.5	-3.0	-2.5	-2.9
Ulcerative Colitis	2.8	4.1	6.7	1.7	2.5	1.8	2.6	1.8	1.6	1.8
Qualifications: CSEs or equivalent	2.8	3.8	7.4	-1.2	-1.3	-2.4	-1.2	-2.7	-2.3	-1.8
Financial difficulties in last 2 years	2.8	3.8	5.6	-2.3	-1.5	-2.0	-1.9	-2.4	-1.6	-1.8
Fluid intelligence score	2.8	5.9	9.4	-0.7	-2.5	-2.9	-1.7	-3.1	-2.7	-2.5
Alcohol intake versus 10 years previously	2.6	3.8	7.8	-2.2	-2.2	-1.7	-2.8	-1.9	-0.9	-1.3
Relative age voice broke	2.5	3.8	8.5	-2.3	-2.8	-1.2	-2.9	-1.4	-0.9	-1.0
Angina	2.4	3.1	6.9	-2.1	-1.3	-1.7	-2.6	-1.4	0.6	-1.8
Pulse rate	2.4	4.1	6.9	-1.2	-2.1	-2.2	-1.9	-2.6	-2.2	-1.4
Illnesses of father: High blood pressure	2.4	3.0	4.4	-1.2	-1.6	-1.8	-1.9	-2.1	-1.4	-1.8
Intelligence (Savage-Jansen 2018)	2.3	7.1	11.5	-1.1	-2.9	-3.2	-3.4	-2.8	-1.9	-2.7
Pack years adult smoking proportion	2.3	3.5	5.9	-2.4	-1.6	-2.0	-2.0	-2.2	-1.4	-1.1
Pack years of smoking	2.3	3.4	5.6	-2.4	-1.7	-2.0	-2.0	-2.2	-1.4	-1.0
Loud music exposure frequency	2.1	2.2	4.7	-2.2	-1.6	-1.5	-0.9	-1.4	-1.7	-0.7
Commuting to job workplace: Walk	2.1	2.3	4.3	-1.0	-2.1	-1.4	-1.8	-1.5	-1.2	-1.3
Eye problems/disorders: Glaucoma	2.1	2.5	6.0	1.7	1.5	1.6	2.5	1.0	0.4	1.4
Headache pain in last month	2.0	3.5	8.4	0.9	2.3	2.0	2.9	1.8	0.3	1.7
Medication for cholesterol, blood pressure or diabetes	2.0	3.3	6.5	0.9	1.5	2.2	2.6	1.9	0.9	2.0
Angina (self-reported)	2.0	2.6	5.7	-2.0	-1.1	-1.5	-2.4	-1.2	0.8	-1.7
Hair/balding pattern: Pattern 3	1.9	2.9	5.7	0.1	-2.4	-1.7	-0.6	-1.8	-2.0	-2.0
High cholesterol (Self-reported)	1.9	3.4	8.9	-2.1	-2.0	-1.8	-3.0	-1.6	-0.7	-0.8
Irritable Bowel Disease (IBD)	1.8	4.2	6.7	0.4	2.5	2.3	2.3	2.1	1.1	2.6
Taking other prescription medications	1.8	2.8	4.1	-2.0	-1.9	-1.7	-1.7	-1.9	-1.2	-1.3
Alzheimer’s Disease (in mother)	1.7	2.0	3.6	-0.0	-1.4	-1.8	-1.4	-1.9	-1.4	-1.2
Osteoporosis (self-reported)	1.7	2.0	5.6	-1.7	-1.5	-1.0	-2.4	-1.3	-0.0	-0.9
Miserableness	1.7	2.9	8.0	-2.8	-1.5	-1.0	-0.2	-1.6	-2.6	-0.3
Ulcerative Colitis (UC)	1.6	3.0	4.7	1.3	2.2	1.6	2.1	1.7	1.2	1.7
Supplements: Zinc	1.6	1.7	4.0	2.0	1.8	0.7	1.1	0.8	1.4	0.2
Birth weight of first child	1.6	2.9	6.9	2.1	1.5	1.4	2.6	1.6	0.2	1.6
Supplements: Vitamin C	1.6	1.8	4.3	-0.5	-1.0	-1.7	-2.1	-1.3	-0.7	-1.5
Depressed Affect (Nagel 2018)	1.5	3.2	10.8	-3.3	-1.9	-1.0	-1.2	-1.4	-1.9	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	4.7	-0.1	-1.5	-1.5	-1.2	-1.4	-1.2	-2.2
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	3.1	0.1	1.3	1.7	1.0	1.5	1.7	1.4
Mouth/teeth dental problems	1.5	2.2	5.2	-0.6	1.7	1.6	0.9	1.6	1.3	2.3
Falls in the last year	1.5	2.0	2.8	-1.2	-1.5	-1.7	-1.2	-1.7	-1.3	-1.3
Commuting to job workplace: Public transport	1.5	1.7	4.6	-0.8	-1.4	-1.4	-2.1	-1.3	-0.4	-1.1
Pain type(s) experienced in last month: Hip pain	1.5	1.9	4.1	-0.5	-1.8	-1.2	-0.6	-2.0	-1.4	-1.4
Crohns Disease (2012)	1.4	2.2	4.1	0.4	1.7	1.8	1.7	1.5	0.4	2.0
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	3.8	0.6	1.4	1.1	0.8	1.6	2.0	0.8
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.3	5.9	0.1	-1.2	-2.2	0.2	-2.4	-2.3	-2.2
Serious illness, injury or assault to yourself	1.4	1.7	5.1	1.8	1.4	0.7	0.1	1.0	2.3	0.7
Sensitivity / hurt feelings	1.3	2.3	3.6	1.0	1.1	1.7	1.8	1.7	1.0	1.9
Multivitamins +/- minerals	1.3	1.7	3.6	0.5	-1.0	-1.6	-1.6	-1.3	-0.4	-1.9
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	2.6	-0.8	-0.7	-1.6	-1.0	-1.6	-1.6	-1.2
Chronotype (morning person)	1.2	2.8	7.3	-0.4	0.4	2.2	1.3	2.7	1.3	2.0
Vitamin and mineral supplements	1.2	1.6	4.2	-0.7	0.7	1.6	1.4	1.2	0.4	2.0
Fed-up feelings	1.2	2.1	5.6	-2.4	-1.7	-1.0	-0.6	-1.5	-1.7	-0.3
Blood clot in the leg (DVT)	1.2	1.5	2.4	0.8	1.0	1.3	1.3	1.5	0.9	1.6
Eye problems/disorders: None of the above	1.2	1.4	2.6	-1.6	-1.3	-1.2	-1.1	-0.6	-1.1	-1.0
Fractured/broken bones in last 5 years	1.2	1.5	5.9	-2.4	-0.6	1.2	-0.6	0.8	0.4	1.4
Severe depression (siblings)	1.1	1.2	2.8	0.6	-0.5	-1.7	-0.6	-1.1	-1.4	-1.3
Stomach or abdominal pain in last month	1.1	1.4	2.5	-0.2	1.6	1.4	1.6	0.9	0.1	1.4
Medication: Bendroflumethiazide	1.1	1.7	2.3	0.8	1.5	1.3	1.3	1.4	1.0	1.5
Crohns Disease (2017)	1.0	2.1	5.2	-0.7	1.4	1.8	1.3	1.5	0.4	2.3
Pain all over the body in last month	1.0	1.1	2.3	0.2	0.4	1.5	1.1	1.5	1.0	0.9
Medication: Lansoprazole	1.0	1.1	3.7	-1.9	0.6	0.2	-1.4	0.6	1.3	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.1	4.3	-2.1	-1.4	-1.7	-2.0	-1.9	-1.2	-1.8
Qualifications: O levels/GCSEs or equivalent	1.0	1.5	2.5	1.6	-0.6	-0.9	1.4	-1.0	-1.6	-1.2
Medication: Ventolin 100micrograms inhaler	1.0	1.3	4.5	-2.1	-0.7	-0.8	-1.1	-0.6	-1.2	-0.3
Emphysema/chronic bronchitis	1.0	1.1	2.8	0.5	-1.2	-1.2	-0.6	-0.9	-0.8	-1.7
Medication: Allopurinol	1.0	1.3	3.3	-1.8	-0.1	1.2	0.4	1.0	1.1	1.5
Had major operations	1.0	1.1	5.5	-2.4	-0.4	0.0	-1.1	-0.1	-0.1	1.1
Leg pain on walking	1.0	1.3	4.6	0.3	-0.8	-0.9	0.3	-1.0	-2.2	-1.3
Commuting to job workplace: Car/motor vehicle	1.0	1.2	2.6	0.6	1.1	1.4	1.6	1.2	0.7	0.7
Mineral and other dietary supplements	1.0	1.3	3.5	-0.5	1.3	1.3	0.1	1.0	1.1	1.9
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	2.1	0.9	0.9	1.2	1.3	1.3	0.8	1.4
Blood Red Count	0.9	8.6	11.5	-1.3	-3.0	-3.4	-3.4	-2.9	-2.7	-3.3
Noisy workplace	0.9	1.1	2.8	1.3	1.1	0.7	1.7	1.1	0.2	0.2
Length of working week for main job	0.9	1.0	2.1	-0.1	-0.6	-1.4	-1.2	-1.3	-0.5	-1.1
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	3.3	1.8	0.9	0.9	1.2	1.0	0.9	-0.0
Chronic bronchitis/emphysema (mother)	0.9	1.1	5.0	2.2	0.7	0.4	1.1	0.9	0.2	-0.2
Pulse rate, automated reading	0.9	2.8	5.6	-0.5	-1.3	-2.0	-1.7	-2.4	-1.5	-1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	2.0	-0.8	1.2	1.0	-0.1	1.0	1.4	1.2
Asthma (self-reported)	0.9	1.7	2.8	-0.9	1.3	1.7	1.4	1.4	0.4	1.6
Depression (Nagel 2018)	0.8	1.2	1.7	-1.0	-1.3	-1.1	-0.9	-1.0	-1.3	-1.0
Alzheimer’s Disease (including proxy)	0.8	1.2	1.6	-0.5	-1.3	-1.1	-1.0	-1.3	-1.1	-1.1
Mean Putamen Volume	0.8	0.9	2.3	-0.2	-0.7	-0.9	-1.5	-0.7	-0.2	-1.4
Triglycerides	0.8	1.3	2.5	0.2	0.8	1.4	1.6	1.6	0.0	1.3
Heel T-Score	0.8	6.4	12.2	2.7	-0.7	-2.8	0.1	-2.7	-3.5	-3.0
Respiratory disease	0.8	1.9	4.3	-2.1	0.8	1.4	1.5	1.4	-0.3	1.3
Lung FVC	0.8	4.1	8.2	0.2	-1.3	-2.6	-2.3	-2.5	-0.7	-2.9
Medication: Co-codamol	0.8	0.9	6.1	-2.5	-0.0	0.0	0.2	-0.4	-0.1	-0.5
Townsend deprivation index at recruitment	0.8	1.1	2.0	-0.3	-1.0	-1.3	-0.4	-1.2	-1.4	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	3.8	-0.2	-0.6	-1.6	0.4	-1.9	-2.0	-1.4
Qualifications: None of the above	0.8	1.7	3.1	-1.0	0.6	1.8	1.1	1.7	0.7	1.7
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.8	0.6	0.8	1.1	1.7	1.3	-0.2	0.7
Gout (self-reported)	0.8	1.2	2.4	-1.6	-0.2	1.1	0.2	1.4	1.1	1.1
Number of children fathered	0.8	0.9	2.2	-0.4	0.2	1.4	1.5	1.1	-0.3	0.8
Shortness of breath walking on level ground	0.8	0.9	2.4	0.3	1.2	1.1	1.5	0.9	-0.2	0.8
Medication: Blood pressure	0.8	1.4	3.4	-0.1	-1.0	-1.4	-1.4	-1.1	-0.7	-1.8
Medication: Ibuprofen	0.8	0.9	2.5	1.3	0.8	0.7	1.6	1.0	-0.4	0.2
Number of treatments/medications taken	0.7	1.2	3.2	-1.7	-0.8	-1.0	-1.8	-0.8	-0.1	-0.5
Chronic bronchitis/emphysema (father)	0.7	0.8	1.9	0.2	-0.6	-1.3	-0.8	-0.9	-0.1	-1.4
Qualifications: A levels/AS levels or equivalent	0.7	1.5	2.4	0.7	-1.2	-1.6	-0.7	-1.3	-1.3	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	2.3	0.8	0.8	1.1	1.5	1.0	0.4	0.4
Illnesses of father: Heart disease	0.7	1.0	1.7	1.1	0.9	1.2	0.4	1.3	1.2	0.4
Long-standing illness, disability or infirmity	0.7	1.1	2.3	-1.4	-0.3	-1.1	-1.1	-1.5	-1.1	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	2.0	-1.3	-1.2	-1.2	-1.4	-1.3	-1.1	-1.0
Wears glasses or contact lenses	0.7	0.8	1.8	-1.1	-1.3	-0.6	-1.3	-0.7	-0.5	-0.4
Medication: Paracetamol	0.7	1.1	2.6	1.0	1.6	1.1	0.9	1.0	0.4	0.8
Alzheimer’s Disease (in father)	0.6	0.7	1.9	-1.4	-1.2	-0.0	-0.9	-0.1	-0.0	-0.6
Hypothyroidism (self reported)	0.6	1.4	3.5	0.4	-0.9	-1.4	-0.3	-1.5	-1.9	-1.1
Medication for hormone replacement therapy	0.6	0.6	2.4	0.1	0.3	0.4	0.4	1.3	1.5	0.2
Heart attack	0.6	0.7	2.3	-0.8	-0.8	-0.5	-1.5	0.2	0.6	-0.8
Medication: Simvastatin	0.6	0.9	2.3	-1.2	-1.5	-0.9	-1.0	-0.5	-0.8	-0.4
Father’s age at death	0.6	0.8	1.5	1.0	1.2	0.9	0.4	0.8	0.9	0.8
Exposure to tobacco smoke at home	0.6	0.7	2.5	-0.5	0.8	0.6	0.0	0.8	1.6	0.6
Exposure to tobacco smoke outside home	0.6	0.8	2.4	-1.5	-1.0	-0.5	-1.4	-0.3	0.2	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	2.4	-1.5	-1.3	-0.2	-0.6	-0.5	-0.6	0.1
Ever taken oral contraceptive pill	0.6	0.7	1.4	-0.6	0.0	-0.8	-0.7	-1.1	-1.2	-0.7
Tinnitus: Yes, now most or all of the time	0.6	0.8	1.7	-1.3	0.5	1.1	0.7	0.7	0.9	0.4
Unable to work because of sickness or disability	0.6	0.8	1.5	-1.2	-1.2	-0.9	-0.4	-0.9	-0.8	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	1.7	-0.0	1.1	1.0	0.6	1.1	1.3	0.4
Neuroticism (Nagel 2018)	0.5	1.1	3.8	-1.9	-1.4	-0.5	-0.3	-0.6	-1.3	-0.1
Breast Cancer	0.5	1.3	4.9	-0.5	1.3	0.1	-1.5	0.1	2.2	0.2
Age at First Birth	0.5	0.7	3.2	1.8	0.3	0.4	0.7	0.6	0.4	0.5
Coronary Artery Disease (CAD)	0.5	0.6	3.2	-1.8	-0.1	0.3	-0.3	0.1	0.5	0.9
Tanning	0.5	5.7	11.7	-0.1	-2.4	-2.8	-0.9	-3.1	-3.4	-2.0
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.3	-1.0	-1.1	-0.7	-0.5	-0.7	-0.9	-0.4
Diabetes (mother)	0.5	0.7	3.6	0.6	-0.2	-0.4	0.7	-0.5	-1.9	-0.1
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.2	0.2	0.7	0.6	0.0	1.1	1.0	0.6
Medication: Ramipril	0.5	0.7	2.3	0.2	-0.9	-0.7	0.0	-0.6	-1.5	-0.9
Mouth/teeth dental problems: Dentures	0.5	0.8	3.6	1.9	0.7	0.4	1.0	0.5	0.6	-0.2
Asthma	0.5	1.0	1.5	-1.1	0.9	1.2	0.9	1.0	0.0	1.2
Illnesses of mother	0.5	0.6	3.0	-1.7	-0.5	0.2	-0.9	-0.0	0.3	0.6
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	1.7	0.5	-0.9	-1.1	-0.1	-1.2	-1.3	-1.2
Neck or shoulder pain in last month	0.5	0.7	2.0	1.4	0.7	-0.2	1.2	-0.0	-1.0	-0.1
Medication: Omeprazole	0.5	0.6	1.6	-0.8	-0.7	-0.5	-1.3	-0.3	0.4	-0.8
Average weekly red wine intake	0.5	0.8	3.1	0.1	1.0	0.7	-0.8	0.0	1.8	0.3
Loneliness, isolation	0.5	0.7	1.6	-0.9	-1.3	-0.9	-0.7	-0.4	-1.0	0.1
Ever had bowel cancer screening	0.5	0.6	2.3	-0.5	-1.1	-0.4	-1.5	-0.4	-0.2	-0.0
Osteoarthritis (self-reported)	0.5	0.6	1.5	-1.1	-0.8	-0.3	-1.2	-0.8	0.0	-0.5
Financial situation satisfaction	0.5	0.6	2.0	-0.7	-0.7	-0.5	-1.4	0.0	0.9	-0.2
Medication: Atorvastatin	0.5	0.6	1.9	-0.8	-0.7	-0.8	-1.4	-0.8	-0.2	-0.5
Leg fat percentage (left)	0.5	1.8	4.2	0.9	-0.3	-1.6	-0.1	-1.7	-1.3	-2.1
Cholesterol lowering medication	0.5	0.7	1.7	-0.7	-0.0	1.0	-0.2	1.1	0.9	1.3
Heart attack/myocardial infarction (self-reported)	0.5	0.7	2.2	-0.9	-0.8	-0.4	-1.5	0.2	0.7	-0.7
Heart disease (siblings)	0.5	0.6	1.8	0.5	0.2	-0.2	1.2	0.1	-1.3	-0.9
Schizophrenia vs Biploar Disorder	0.4	0.6	1.1	-1.1	0.6	0.7	0.7	0.2	0.7	0.9
Major Depression (MDD)	0.4	0.5	0.9	0.2	0.2	0.9	0.9	0.8	0.7	0.8
Ovarian Cancer	0.4	0.5	2.8	-1.7	-0.4	0.1	0.5	-0.0	-0.7	0.2
LDL Cholesterol	0.4	0.6	3.5	-1.9	-0.6	0.3	-0.4	-0.1	0.3	0.1
Primary Biliary Cirrhosis	0.4	0.6	2.6	-1.6	-1.1	0.1	-0.5	-0.1	0.0	0.0
Lung FEV1/FVC ratio	0.4	2.0	6.2	-2.5	-1.0	-0.7	-2.2	-0.7	-0.7	0.3
Average weekly spirits intake	0.4	0.5	1.0	-0.7	-0.8	0.1	1.0	-0.4	-0.8	-0.4
Systolic blood pressure, automated reading	0.4	1.2	3.1	1.6	1.0	0.6	1.8	0.9	0.7	-0.2
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.6	-0.7	0.7	0.7	0.3	0.7	0.4	0.8
Medication: Metformin	0.4	0.5	1.4	-0.7	-0.7	-0.6	-0.1	-0.9	-1.2	0.0
Alcohol usually taken with meals	0.4	0.6	1.4	-1.2	0.4	0.5	-1.0	-0.4	0.4	0.9
Hearing difficulty/problems with background noise	0.4	0.7	1.3	-0.8	0.6	1.1	0.4	1.1	0.3	1.0
Time employed in main current job	0.4	0.4	1.2	0.8	-0.4	-0.4	-0.0	-0.5	0.6	-1.1
Worrier / anxious feelings	0.4	0.8	1.8	0.1	0.1	1.0	0.4	1.2	0.9	1.3
Number of live births	0.4	0.5	2.1	0.1	1.4	0.9	0.7	0.2	0.2	0.4
Prospective memory result	0.4	0.5	0.9	-0.7	0.1	1.0	0.5	0.8	0.6	0.9
Lung cancer (father)	0.4	0.4	1.5	-1.2	0.1	0.2	-0.2	0.5	0.2	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.2	0.7	-0.8	-0.7	0.2	-0.9	-0.7	-1.1
Birth weight	0.4	0.9	2.8	1.6	0.2	0.6	1.7	0.7	0.0	-0.0
High blood pressure (siblings)	0.4	0.6	1.4	0.9	1.1	0.5	0.4	0.5	1.2	0.0
Leg fat percentage (right)	0.4	1.6	3.7	0.3	-0.7	-1.5	-0.3	-1.7	-1.4	-1.9
Number of full brothers	0.4	0.5	1.2	0.4	1.0	0.4	0.6	0.5	1.1	-0.5
Worry too long after embarrassment	0.4	0.6	1.9	1.4	0.5	-0.3	1.4	0.3	-0.5	-0.0
Qualifications: College or University degree	0.4	1.2	4.0	2.0	-0.3	-0.9	-1.4	-0.4	0.4	-1.2
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.4	0.9	-1.2	-0.3	-0.7	-0.6	0.0	-0.3
Chest pain or discomfort	0.4	0.6	2.1	-0.2	-0.9	-0.7	-0.2	-0.4	-0.9	-1.4
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	1.1	-1.1	-0.6	-0.3	-1.0	-0.5	-0.1	0.4
Knee pain experienced in last month	0.4	0.7	1.4	0.8	-0.3	-0.9	-0.7	-1.2	-0.2	-1.1
Hypertension (Self-reported)	0.4	1.1	1.9	1.4	1.1	0.9	0.5	1.3	0.8	1.1
Eye problems/disorders: Cataract	0.4	0.4	2.4	1.5	0.3	0.2	0.5	-0.2	0.4	-0.3
Illnesses of father: None of the above (group 1)	0.4	0.5	1.7	0.7	0.5	0.5	1.3	0.4	-0.4	0.9
Supplements: Fish oil (including cod liver oil)	0.4	0.6	1.6	0.6	-0.5	-0.6	0.7	-0.4	-0.8	-1.3
Medication: Lisinopril	0.4	0.5	1.1	0.3	0.8	0.9	0.5	0.8	1.0	0.4
Average weekly beer plus cider intake	0.4	0.6	1.3	-1.0	-0.8	-0.3	0.4	-0.7	-1.1	-0.7
Irritability	0.4	0.7	1.5	-0.7	-0.9	-0.6	-0.7	-1.0	-0.6	-1.2
Commuting to job workplace: Cycle	0.4	0.5	1.7	0.4	0.3	0.0	-1.3	0.2	1.3	-0.3
Alcohol drinker status: Previous	0.4	0.4	1.0	0.9	1.0	0.6	0.6	0.6	-0.1	0.4
Bipolar Disorder (2018)	0.3	0.5	1.8	1.4	0.5	-0.2	-0.5	0.5	0.8	-0.6
Worry (Nagel 2018)	0.3	0.6	1.5	-1.2	-1.2	-0.2	-0.8	-0.3	-0.3	0.1
Reaction Time	0.3	0.6	1.2	0.9	0.1	0.8	1.1	1.1	0.2	0.8
HbA1C	0.3	0.4	1.1	0.0	-0.2	-0.0	1.0	-0.3	-1.0	-0.5
HDL Cholesterol	0.3	0.4	1.1	-0.2	-0.2	-1.1	-0.3	-0.9	-0.1	-1.0
Lupus	0.3	0.4	1.2	0.4	0.3	-0.4	-0.5	0.1	1.0	-1.1
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.3	1.2	0.5	0.2	-0.0	0.1	0.9	0.1
Waist Hip Ratio (WHR)	0.3	1.5	2.7	-1.6	-1.6	-1.0	-1.3	-0.9	-0.5	-1.2
Neuroticism	0.3	0.8	4.1	-2.0	-1.0	-0.1	-0.5	-0.2	-0.5	0.4
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.1	-0.3	-0.4	0.7	0.4	0.7	0.3	1.0
Current tobacco smoking	0.3	0.5	2.5	-0.7	-0.2	-0.4	-1.6	-0.6	0.5	0.1
Maternal smoking around birth	0.3	0.4	1.2	1.1	-0.2	0.7	0.4	0.8	0.7	0.1
Age when periods started (menarche)	0.3	0.7	2.0	1.3	1.1	0.1	1.4	0.3	-0.5	-0.1
High blood pressure	0.3	0.9	1.8	1.3	1.0	0.8	0.6	1.3	0.7	0.9
Number of incorrect matches in round	0.3	0.4	1.0	0.4	-0.3	-1.0	0.0	-0.7	-1.0	-0.7
Past tobacco smoking	0.3	0.5	1.5	-0.2	0.5	0.8	0.3	0.7	0.8	1.2
Had menopause	0.3	0.3	0.8	0.0	-0.6	0.3	-0.6	0.9	0.7	0.5
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.0	1.0	0.4	-0.1	-0.3	0.2	0.6	-1.0
Illnesses of siblings	0.3	0.4	1.5	-0.6	-0.9	-0.3	-1.2	-0.5	-0.1	-0.1
Impedance of arm (right)	0.3	1.4	2.8	-0.2	0.7	1.5	1.4	1.7	0.7	1.4
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	3.0	-1.7	-0.6	-0.7	-1.2	-0.8	-0.8	-0.8
Depression (self-reported)	0.3	0.4	1.1	-0.9	-0.4	-0.4	-1.0	-0.4	0.4	-0.5
Pulse wave Arterial Stiffness index	0.3	0.4	1.6	1.3	0.5	-0.0	0.8	0.1	-0.2	0.5
Medication: Paracetamol	0.3	0.6	1.4	0.4	1.2	0.7	1.0	0.8	-0.3	0.3
Medication: Amlodipine	0.3	0.4	1.0	-0.5	1.0	0.7	0.1	0.2	0.8	0.6
Forced vital capacity (FVC), Best measure	0.3	1.0	1.7	-1.3	-0.7	-0.9	-0.9	-1.1	-0.5	-1.3
Wheeze or whistling in the chest in last year	0.3	0.5	1.8	-1.3	0.3	0.7	0.4	0.1	-0.3	1.0
Age at first live birth	0.3	0.5	2.4	1.5	0.2	-0.5	-0.3	-0.2	0.5	-0.3
Pulse wave peak to peak time	0.3	0.3	1.4	-1.2	-0.4	0.1	-0.7	-0.0	0.3	-0.4
Migraine (self-reported)	0.3	0.4	1.2	-0.7	-0.2	0.6	-0.3	0.4	-0.0	1.1
Medication: Seretide 50 evohaler	0.3	0.4	1.0	-0.8	0.3	-0.2	-0.2	-0.5	1.0	-0.8
Heart disease (mother)	0.3	0.3	0.8	0.8	-0.0	-0.2	0.9	0.3	-0.3	-0.7
Leg fat mass (right)	0.3	1.2	2.3	0.5	-0.5	-1.2	0.1	-1.5	-1.3	-1.4
Alcohol intake frequency.	0.3	0.6	2.0	-0.9	-0.1	-0.8	-0.4	-0.7	-1.4	-0.1
Family relationship satisfaction	0.3	0.4	1.9	-1.4	-0.5	-0.4	-0.5	-0.2	-0.4	0.0
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.3	-0.8	0.3	0.0	-1.1	0.0	0.8	0.3
Diabetes diagnosed by doctor	0.3	0.4	0.8	-0.8	-0.5	-0.6	-0.9	-0.7	-0.7	-0.0
Smoking status: Current	0.3	0.4	1.8	-0.3	0.3	-0.3	-1.4	-0.4	0.8	-0.0
Number of self-reported non-cancer illnesses	0.3	0.5	0.8	0.1	-0.5	-0.9	-0.8	-0.8	-0.8	-0.7
Hearing aid user	0.3	0.3	0.7	0.4	0.1	-0.6	0.4	-0.6	-0.9	-0.6
Diastolic blood pressure, automated reading	0.3	0.9	2.7	1.6	0.9	0.2	1.6	0.2	-0.2	-0.1
Vascular/heart problems diagnosed by doctor	0.3	0.9	1.6	-1.2	-1.0	-0.6	-0.1	-1.3	-1.3	-0.7
Leg fat mass (left)	0.3	1.1	2.2	0.8	-0.3	-1.2	0.3	-1.5	-1.3	-1.3
Fasting Glucose	0.2	0.2	0.8	-0.3	-0.0	0.6	0.9	0.3	0.1	-0.1
Neuroticism (2016)	0.2	0.3	1.3	-0.3	0.2	0.3	-0.1	0.6	1.1	0.4
Systolic Blood Pressure	0.2	1.2	2.0	1.1	1.4	0.7	1.4	1.1	1.3	-0.4
Smoking Status	0.2	0.5	1.2	-0.3	-0.4	-0.7	-1.0	-0.8	-0.0	-1.1
Cardiovascular Disease	0.2	0.6	2.2	-0.3	0.4	0.5	-0.8	0.8	1.5	0.6
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.5	-1.2	0.2	0.1	-0.2	-0.3	-0.6	0.8
Hand grip strength (left)	0.2	0.4	1.3	1.1	1.1	0.2	0.5	0.2	0.1	-0.0
Hearing difficulty/problems: Yes	0.2	0.3	0.7	-0.9	-0.3	-0.3	-0.2	-0.5	-0.7	-0.4
Ever had hysterectomy (womb removed)	0.2	0.3	0.6	-0.8	-0.0	0.4	-0.5	0.7	0.6	0.3
High blood pressure (mother)	0.2	0.2	0.8	0.9	0.2	-0.3	0.6	0.1	-0.5	-0.2
Impedance of leg (left)	0.2	0.8	2.9	0.6	-0.1	-1.2	-0.5	-0.7	-0.5	-1.7
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	1.4	-1.2	-0.7	-0.1	0.1	-0.4	-0.7	0.3
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.9	0.8	0.9	-0.1	0.7	-0.3	0.0	-0.1
Neuroticism score	0.2	0.4	1.5	-1.2	-0.6	0.0	-0.1	0.1	-0.5	0.6
Happiness	0.2	0.2	0.4	-0.4	-0.1	0.4	-0.1	0.6	0.5	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.6	-0.5	-0.5	-0.3	-0.3	-0.4	-0.8	-0.6
Impedance of arm (left)	0.2	0.9	1.8	-0.1	0.6	1.2	1.3	1.3	0.7	0.8
Hair/balding pattern: Pattern 4	0.2	0.5	1.4	1.2	0.4	-0.2	-0.4	0.3	0.9	-0.7
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.5	-0.7	-0.2	0.6	0.2	0.5	-0.2	0.6
Glaucoma (self-reported)	0.2	0.2	0.9	1.0	0.2	0.2	0.6	-0.2	-0.1	-0.1
Body fat percentage	0.2	0.7	1.1	0.9	-0.0	-0.7	0.7	-1.0	-0.9	-1.0
Comparative body size at age 10	0.2	0.6	2.4	0.5	-0.2	-0.1	-0.8	-0.3	1.6	-0.8
Health satisfaction	0.2	0.3	0.5	0.5	-0.5	-0.6	-0.4	-0.4	-0.5	-0.7
Medication for pain relief, constipation, heartburn	0.2	0.3	0.6	0.5	-0.7	-0.4	-0.0	-0.8	-0.5	-0.5
Mean time to correctly identify matches	0.2	0.4	1.0	1.0	-0.5	0.3	0.8	0.7	-0.2	0.1
Number of full sisters	0.2	0.2	0.8	-0.6	0.9	-0.3	-0.6	0.0	-0.0	0.1
Mood swings	0.2	0.3	1.1	-0.9	-0.2	-0.1	0.3	-0.1	-1.0	0.1
Friendships satisfaction	0.2	0.3	1.1	-0.1	-0.2	-0.7	-0.4	-0.5	-0.2	-1.0
Medication: Gliclazide	0.2	0.3	0.7	0.8	0.5	-0.3	0.3	-0.6	0.1	-0.6
Average weekly champagne plus white wine intake	0.2	0.2	0.7	-0.4	-0.6	-0.5	-0.8	-0.2	-0.3	0.4
Guilty feelings	0.2	0.3	1.6	-0.6	-1.3	-0.5	-0.2	0.0	-0.2	-0.1
Alcohol drinker status: Never	0.2	0.2	0.7	0.1	0.5	0.4	0.8	0.4	-0.3	0.4
Ever smoked	0.2	0.3	0.8	0.9	0.5	-0.2	0.4	-0.0	-0.5	-0.6
Age started oral contraceptive pill	0.2	0.3	0.6	0.8	-0.7	-0.6	-0.4	-0.4	-0.6	-0.1
Supplements: Calcium	0.2	0.3	0.9	0.2	-0.3	0.1	-0.7	0.3	1.0	-0.4
Bipolar Disorder or Schizophrenia	0.1	0.3	1.2	1.1	-0.0	-0.2	-0.3	0.3	0.3	-1.0
Schizophrenia (2018)	0.1	0.1	0.6	0.3	-0.5	-0.1	0.1	-0.0	-0.3	-0.8
Prostate Cancer	0.1	0.2	0.5	-0.4	0.7	0.1	0.3	0.1	-0.4	0.4
Bipolar Disorder (2011)	0.1	0.1	0.5	0.7	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.1	0.1	0.3	-0.6	-0.1	-0.2	-0.1	-0.5	-0.1	0.2
Blood Platelet Count	0.1	1.1	4.6	-2.1	0.2	0.1	0.8	0.1	-1.6	-0.0
BMI	0.1	0.5	1.3	0.3	0.0	-0.7	0.5	-1.1	-0.8	-0.8
Hair Pigment	0.1	4.2	5.5	1.6	2.0	2.1	2.1	2.3	1.7	2.3
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.4	0.5	0.6	0.1	0.0	0.4	0.3	0.2
Diabetes (father)	0.1	0.1	0.4	0.1	-0.7	-0.0	-0.2	0.4	-0.0	-0.1
Impedance of leg (right)	0.1	0.6	1.9	-0.2	-0.4	-0.9	-0.6	-0.6	-0.5	-1.4
Trunk fat percentage	0.1	0.5	1.2	1.1	0.1	-0.3	1.1	-0.6	-0.7	-0.6
Hand grip strength (right)	0.1	0.2	0.7	0.8	0.8	-0.2	-0.3	-0.2	0.0	-0.1
Medication: Atenolol	0.1	0.2	0.7	-0.8	0.2	-0.0	-0.4	0.2	0.6	-0.0
Medication: Levothyroxine sodium	0.1	0.2	0.5	0.7	0.5	0.3	0.7	0.2	0.0	0.5
Sitting height	0.1	0.6	1.8	-1.3	-0.6	-0.1	-0.0	-0.7	-0.7	0.9
Body mass index (BMI)	0.1	0.4	1.1	0.4	-0.2	-0.7	0.1	-1.1	-0.8	-0.8
Trunk fat mass	0.1	0.5	1.0	0.9	0.1	-0.3	1.0	-0.8	-0.7	-0.5
Nervous feelings	0.1	0.1	0.5	0.1	-0.1	0.3	0.2	0.3	0.7	0.5
Had other major operations	0.1	0.2	0.5	0.2	-0.1	-0.2	-0.5	-0.4	0.1	-0.7
Forced vital capacity (FVC)	0.1	0.2	1.3	-1.1	0.0	-0.0	-0.4	-0.2	-0.0	-0.4
Diabetes (self-reported)	0.1	0.2	0.9	-1.0	-0.2	-0.0	-0.3	-0.0	-0.4	0.5
Weight	0.1	0.3	0.7	0.1	-0.3	-0.4	0.5	-0.9	-0.8	-0.4
Arm fat percentage (right)	0.1	0.3	1.4	0.4	0.4	0.2	1.2	-0.2	-0.5	0.0
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.5	-0.2	0.7	0.3	0.7	0.2	0.5	0.1
Arm fat mass (right)	0.1	0.3	1.0	0.6	0.3	0.1	1.0	-0.4	-0.5	-0.0
Breastfed as a baby	0.1	0.1	0.3	-0.4	-0.2	0.2	-0.3	0.5	0.3	0.5
Pulse wave reflection index	0.1	0.1	0.3	0.0	0.1	-0.1	0.3	-0.0	-0.5	0.5
Arm fat-free mass (right)	0.1	0.5	1.6	0.2	-0.4	-0.8	-0.1	-1.3	-1.0	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.3	0.4	0.0	-0.2	-0.2	0.1	-0.1	0.5
Whole body fat mass	0.1	0.5	0.8	0.8	0.1	-0.4	0.9	-0.8	-0.8	-0.5
Arm predicted mass (right)	0.1	0.3	1.0	0.1	-0.2	-0.5	0.1	-1.0	-0.8	-0.2
Comparative height size at age 10	0.1	0.3	0.7	-0.2	-0.0	0.7	0.8	0.6	0.2	0.8
Suffer from ‘nerves’	0.1	0.2	0.4	-0.5	-0.6	-0.0	-0.2	-0.2	-0.5	0.4
Overall health rating	0.1	0.3	1.3	0.4	0.7	0.3	1.1	0.3	0.1	0.2
Age at last live birth	0.1	0.1	0.5	-0.1	-0.2	-0.1	-0.7	-0.1	0.6	0.1
Illnesses of siblings: Diabetes	0.1	0.1	0.3	-0.0	0.4	-0.5	0.3	-0.5	-0.2	-0.2
Smoking status: Previous	0.1	0.2	0.7	0.1	-0.3	-0.3	0.4	-0.1	-0.8	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.5	-0.5	-0.1	-0.2	0.0	-0.5	0.1	-0.7
Arm fat percentage (left)	0.1	0.3	1.0	0.5	0.2	-0.1	1.0	-0.5	-0.8	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.3	-0.3	0.3	0.2	0.0	0.2	0.4	-0.5
Back pain experienced in last month	0.1	0.2	0.6	-0.3	0.3	0.2	0.8	0.1	-0.1	0.5
Breast cancer (self-reported)	0.1	0.1	0.3	0.3	0.5	-0.4	-0.1	-0.0	0.1	-0.5
Risk taking	0.1	0.2	0.5	0.7	0.1	-0.2	0.2	-0.5	-0.3	-0.4
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	0.3	-0.3	-0.1	0.3	0.0	-0.4	0.2
Ever depressed for a whole week	0.1	0.1	0.4	-0.6	0.2	-0.2	-0.0	-0.2	0.2	-0.1
Basal cell carcinoma (self-reported)	0.1	0.1	0.6	-0.5	-0.8	0.1	0.1	-0.1	-0.2	-0.1
Schizophrenia (2014)	0.0	0.1	0.2	0.3	-0.0	-0.1	0.4	0.1	-0.3	-0.5
Height	0.0	0.7	1.7	0.7	-0.0	0.9	1.1	0.7	0.3	1.3
Leg fat-free mass (left)	0.0	0.2	0.4	-0.3	-0.2	0.2	0.7	-0.4	-0.5	0.4
Leg predicted mass (left)	0.0	0.2	0.5	-0.2	-0.2	0.2	0.7	-0.4	-0.5	0.4
Waist circumference	0.0	0.1	0.4	-0.3	-0.2	-0.3	-0.2	-0.6	-0.3	-0.4
Trunk fat-free mass	0.0	0.1	0.2	-0.4	-0.1	0.1	0.1	-0.4	-0.2	0.4
Hip circumference	0.0	0.2	0.8	0.3	0.2	0.3	0.9	-0.2	-0.4	0.1
Trunk predicted mass	0.0	0.1	0.2	-0.4	-0.1	0.2	0.1	-0.4	-0.2	0.5
Standing height	0.0	0.5	1.1	-0.1	0.0	0.9	1.1	0.5	-0.0	1.0
Tense / ‘highly strung’	0.0	0.0	0.3	0.1	-0.5	-0.1	-0.0	-0.1	0.2	-0.1
Whole body fat-free mass	0.0	0.1	0.2	-0.2	-0.2	0.0	0.3	-0.5	-0.4	0.3
Leg fat-free mass (right)	0.0	0.1	0.4	-0.0	-0.1	0.2	0.6	-0.4	-0.4	0.4
Whole body water mass	0.0	0.1	0.2	-0.2	-0.1	0.1	0.4	-0.4	-0.4	0.4
Leg predicted mass (right)	0.0	0.2	0.5	0.1	-0.0	0.3	0.7	-0.3	-0.4	0.5
Arm fat mass (left)	0.0	0.2	0.7	0.4	0.1	-0.0	0.8	-0.5	-0.5	-0.1
Basal metabolic rate	0.0	0.1	0.3	-0.1	-0.0	0.1	0.5	-0.4	-0.4	0.3
Arm fat-free mass (left)	0.0	0.1	0.2	0.3	0.1	0.0	0.4	-0.3	-0.3	0.2
Number of operations (self-reported)	0.0	0.0	0.1	-0.3	0.2	0.0	-0.2	0.1	0.2	0.0
Impedance of whole body	0.0	0.1	0.2	0.0	0.1	-0.0	0.4	0.3	0.0	-0.3
Arm predicted mass (left)	0.0	0.2	0.8	0.1	-0.3	-0.5	0.1	-0.9	-0.7	-0.3

Hub : Genes

GGT5

Models

Trait associations