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chr22:29,585,080-32,995,751

Best TWAS P=1.1e-30 · Best GWAS P=9.37e-30 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	PIK3IP1	0.05	0.01	blup	347	0.04	1.6e-05	9.29	-6.9	5.3e-12	-0.70	0.07	0.76	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PISD	0.20	0.27	enet	19	0.28	4.0e-34	5.97	5.6	2.5e-08	0.21	1.00	0.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	RNF185	0.09	0.05	enet	21	0.09	1.3e-10	11.22	-11.5	1.1e-30	-0.84	0.01	0.99	TRUE
4	CommonMind	Brain Pre-frontal Cortex	RNF215	0.03	0.00	blup	442	0.00	1.9e-01	4.81	6.3	3.4e-10	0.07	0.01	0.90	TRUE
5	CommonMind	Brain Pre-frontal Cortex	SFI1	0.05	0.01	blup	386	0.04	1.6e-05	-9.92	-10.3	6.9e-25	-0.81	0.03	0.97	FALSE
6	GTEx	Adipose Subcutaneous	RNF185-AS1	0.13	0.05	lasso	7	0.06	7.6e-06	6.18	-5.2	2.2e-07	-0.30	0.51	0.03	FALSE
7	GTEx	Artery Aorta	SFI1	0.10	0.01	enet	23	0.02	1.9e-02	4.65	-6.2	5.4e-10	-0.73	0.11	0.74	FALSE
8	GTEx	Artery Tibial	SFI1	0.12	0.04	enet	21	0.09	8.5e-08	3.75	-6.7	1.7e-11	-0.70	0.16	0.83	FALSE
9	GTEx	Brain Caudate basal ganglia	SFI1	0.19	0.03	enet	45	0.04	2.1e-02	9.19	-6.2	4.5e-10	-0.59	0.06	0.18	FALSE
10	GTEx	Brain Frontal Cortex BA9	MTMR3	0.22	0.10	lasso	5	0.19	8.0e-06	4.83	5.3	1.0e-07	0.04	0.03	0.82	FALSE
11	GTEx	Brain Frontal Cortex BA9	PRR14L	0.28	0.24	lasso	4	0.19	1.1e-05	4.77	-5.3	1.1e-07	-0.16	0.48	0.15	FALSE
12	GTEx	Brain Hypothalamus	EIF4HP2	0.32	0.08	enet	32	0.10	2.2e-03	-0.61	5.1	2.8e-07	0.26	0.12	0.15	FALSE
13	GTEx	Brain Putamen basal ganglia	SFI1	0.23	0.06	enet	18	0.06	1.4e-02	-10.07	-7.5	5.7e-14	-0.64	0.07	0.41	FALSE
14	GTEx	Breast Mammary Tissue (Male)	SFI1	0.10	-0.01	lasso	5	-0.01	7.4e-01	5.55	5.8	5.5e-09	0.25	0.04	0.05	FALSE
15	GTEx	Cells Transformed fibroblasts	SMTN	0.05	0.00	lasso	4	0.00	1.5e-01	2.12	7.9	2.1e-15	0.63	0.03	0.73	FALSE
16	GTEx	Cells Transformed fibroblasts	RNF185-AS1	0.13	0.13	lasso	4	0.12	3.1e-09	6.18	-7.5	9.4e-14	-0.42	1.00	0.00	FALSE
17	GTEx	Colon Sigmoid	SFI1	0.16	0.02	enet	36	0.05	5.4e-03	4.30	-7.1	1.6e-12	-0.61	0.10	0.41	FALSE
18	GTEx	Esophagus Gastroesophageal Junction	SFI1	0.15	0.07	lasso	3	0.06	3.7e-03	9.06	-7.8	4.6e-15	-0.83	0.03	0.83	FALSE
19	GTEx	Esophagus Muscularis	LIMK2	0.08	0.03	lasso	4	0.01	4.3e-02	9.06	-9.8	8.3e-23	-0.93	0.01	0.96	FALSE
20	GTEx	Esophagus Muscularis	SFI1	0.22	0.13	enet	20	0.15	3.7e-09	9.38	-10.0	1.7e-23	-0.88	0.05	0.95	FALSE
21	GTEx	Heart Left Ventricle	SFI1	0.12	0.10	enet	20	0.07	2.3e-04	-10.10	-9.6	1.2e-21	-0.81	0.47	0.42	FALSE
22	GTEx	Muscle Skeletal	SFI1	0.13	0.09	enet	22	0.10	1.7e-10	-10.10	-9.9	6.0e-23	-0.83	0.65	0.35	FALSE
23	GTEx	Nerve Tibial	PIK3IP1	0.09	0.05	enet	11	0.09	3.5e-07	2.48	-7.5	5.2e-14	-0.46	0.83	0.12	FALSE
24	GTEx	Nerve Tibial	SFI1	0.23	0.06	enet	16	0.14	1.9e-10	4.20	-6.0	1.7e-09	-0.73	0.48	0.52	FALSE
25	GTEx	Pancreas	SELM	0.29	0.23	enet	18	0.30	5.2e-13	-5.03	-6.1	8.2e-10	-0.54	0.99	0.01	FALSE
26	GTEx	Skin Not Sun Exposed Suprapubic	SFI1	0.12	0.00	enet	12	0.05	1.4e-03	9.20	-8.9	6.7e-19	-0.78	0.03	0.93	FALSE
27	GTEx	Skin Sun Exposed Lower leg	SFI1	0.12	0.02	enet	24	0.05	3.6e-05	9.38	-5.2	2.0e-07	-0.57	0.14	0.49	TRUE
28	GTEx	Skin Sun Exposed Lower leg	RNF185-AS1	0.08	0.03	lasso	5	0.02	4.1e-03	2.99	-5.5	3.2e-08	-0.28	0.15	0.05	FALSE
29	GTEx	Testis	RP1-130H16.16	0.25	0.17	lasso	4	0.20	3.3e-09	-3.43	-5.2	1.8e-07	-0.05	0.10	0.90	FALSE
30	GTEx	Thyroid	RNF185	0.05	0.03	lasso	4	0.02	5.1e-03	10.66	11.0	2.8e-28	0.95	0.02	0.97	FALSE
31	GTEx	Whole Blood	SFI1	0.05	0.05	lasso	2	0.04	3.0e-04	9.29	-9.3	9.3e-21	-0.88	0.08	0.86	FALSE
32	METSIM	Adipose	MORC2	0.04	0.00	bslmm	396	0.01	8.8e-03	-0.81	-6.4	1.8e-10	-0.53	0.06	0.23	FALSE
33	METSIM	Adipose	SELM	0.06	0.03	enet	21	0.05	1.6e-08	-8.19	-8.6	7.0e-18	-0.67	0.04	0.96	FALSE
34	NTR	Blood	DEPDC5	0.02	0.02	lasso	5	0.01	2.4e-05	7.49	-7.8	7.2e-15	-0.67	0.56	0.39	FALSE
35	NTR	Blood	PIK3IP1	0.03	0.01	blup	346	0.02	7.3e-07	9.64	5.5	3.1e-08	0.22	0.99	0.00	FALSE
36	NTR	Blood	PISD	0.05	0.08	lasso	5	0.09	3.3e-27	7.49	-8.9	3.9e-19	-0.70	1.00	0.00	FALSE
37	YFS	Blood	EIF4ENIF1	0.01	0.00	blup	362	0.01	9.7e-04	-6.86	-7.2	5.8e-13	-0.54	0.06	0.14	TRUE
38	YFS	Blood	LIMK2	0.04	0.04	enet	9	0.06	3.6e-18	9.29	7.6	3.4e-14	0.80	0.97	0.03	FALSE
39	YFS	Blood	PISD	0.36	0.32	lasso	9	0.35	5.1e-122	7.49	-7.6	2.2e-14	-0.66	1.00	0.00	TRUE
40	YFS	Blood	RNF185	0.04	0.03	lasso	4	0.03	2.8e-09	9.19	9.2	3.0e-20	0.86	0.96	0.04	TRUE
41	YFS	Blood	SFI1	0.19	0.14	enet	36	0.24	9.8e-76	3.26	-6.3	2.4e-10	-0.65	1.00	0.00	FALSE
42	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SELM	0.06	0.01	blup	54	0.02	5.2e-03	-5.03	8.6	8.7e-18	0.75	0.02	0.91	FALSE
43	The Cancer Genome Atlas	Breast Invasive Carcinoma	SFI1	0.02	0.00	blup	94	0.01	2.3e-02	7.44	-10.0	1.9e-23	-0.65	0.02	0.93	FALSE
44	The Cancer Genome Atlas	Colon Adenocarcinoma	EIF4ENIF1	0.08	0.06	enet	5	0.06	3.4e-04	10.42	9.3	1.2e-20	0.94	0.00	0.99	FALSE
45	The Cancer Genome Atlas	Colon Adenocarcinoma	PISD	0.05	0.00	blup	54	0.05	1.0e-03	6.82	9.1	1.0e-19	0.60	0.02	0.77	FALSE
46	The Cancer Genome Atlas	Glioblastoma Multiforme	SFI1	0.23	0.03	blup	93	0.04	2.7e-02	6.88	-8.2	1.9e-16	-0.63	0.03	0.21	FALSE
47	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SELM	0.03	0.04	lasso	1	0.02	7.4e-04	-7.48	7.5	7.3e-14	0.50	0.25	0.05	FALSE
48	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SFI1	0.05	0.06	enet	3	0.04	1.9e-05	-9.92	-10.2	2.7e-24	-0.82	0.01	0.99	FALSE
49	The Cancer Genome Atlas	Brain Lower Grade Glioma	LIMK2	0.06	0.06	blup	47	0.06	9.3e-08	4.14	-6.0	1.6e-09	-0.74	0.76	0.24	FALSE
50	The Cancer Genome Atlas	Brain Lower Grade Glioma	PISD	0.03	0.02	blup	54	0.03	6.5e-04	5.55	5.6	2.6e-08	0.22	0.08	0.07	FALSE
51	The Cancer Genome Atlas	Brain Lower Grade Glioma	SFI1	0.05	0.04	blup	94	0.06	9.4e-08	6.80	-7.5	7.7e-14	-0.39	0.06	0.93	FALSE
52	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PISD	0.06	0.04	blup	54	0.05	2.9e-03	4.30	6.0	2.7e-09	0.20	0.14	0.13	FALSE
53	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PISD	0.03	0.00	blup	53	0.02	1.3e-03	5.52	7.5	9.5e-14	0.41	0.04	0.21	FALSE
54	The Cancer Genome Atlas	Prostate Adenocarcinoma	PISD	0.06	0.01	lasso	4	0.04	7.7e-05	5.76	8.6	8.7e-18	0.53	0.02	0.97	FALSE
55	The Cancer Genome Atlas	Prostate Adenocarcinoma	RNF185	0.06	0.05	blup	54	0.05	4.7e-06	6.06	5.3	8.8e-08	0.51	0.49	0.18	TRUE
56	The Cancer Genome Atlas	Prostate Adenocarcinoma	SEC14L2	0.12	0.08	blup	74	0.12	1.1e-12	-3.43	5.5	3.0e-08	0.07	0.64	0.18	FALSE
57	The Cancer Genome Atlas	Prostate Adenocarcinoma	SFI1	0.05	0.03	lasso	4	0.02	2.4e-03	-10.03	-10.2	1.8e-24	-0.78	0.01	0.96	FALSE
58	The Cancer Genome Atlas	Rectum Adenocarcinoma	RNF185	0.18	0.10	enet	6	0.12	9.7e-04	6.03	7.0	2.2e-12	0.74	0.03	0.26	TRUE
59	The Cancer Genome Atlas	Thyroid Carcinoma	RNF185	0.06	0.09	lasso	4	0.07	1.5e-07	6.38	6.1	1.3e-09	0.73	0.80	0.19	FALSE
60	The Cancer Genome Atlas	Thyroid Carcinoma	SELM	0.04	0.00	blup	54	0.01	4.8e-02	4.10	-6.9	5.1e-12	-0.61	0.01	0.84	FALSE
61	The Cancer Genome Atlas	Thyroid Carcinoma	SFI1	0.15	0.16	blup	94	0.16	6.5e-15	-9.92	-8.8	1.6e-18	-0.57	0.02	0.98	FALSE