Hub : Genes

KB-226F1.2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.225 0.0520 3.8e-09 0.169 NA 0.158 NA 0.167 8.5e-14 NA 6.4e-13 NA 1.2e-13
2 GTEx Adipose Visceral Omentum 0.305 0.0610 4.8e-09 0.212 NA 0.209 NA 0.218 2.8e-11 NA 4.1e-11 NA 1.4e-11
3 GTEx Adrenal Gland 0.230 0.0747 5.3e-04 0.062 NA 0.023 NA 0.033 2.9e-03 NA 4.9e-02 NA 2.4e-02
4 GTEx Artery Aorta 0.127 0.0490 2.7e-03 0.055 NA 0.050 NA 0.056 5.6e-04 NA 9.7e-04 NA 4.8e-04
5 GTEx Brain Cerebellar Hemisphere 0.245 0.0890 3.8e-03 0.092 NA 0.107 NA 0.107 2.4e-03 NA 1.1e-03 NA 1.1e-03
6 GTEx Brain Cerebellum 0.322 0.0860 8.6e-05 0.103 NA 0.140 NA 0.115 5.9e-04 NA 6.3e-05 NA 2.9e-04
7 GTEx Brain Nucleus accumbens basal ganglia 0.277 0.0890 1.6e-03 0.010 NA 0.031 NA 0.030 1.7e-01 NA 5.1e-02 NA 5.3e-02
8 GTEx Brain Putamen basal ganglia 0.239 0.0860 3.6e-03 0.144 NA 0.097 NA 0.196 2.8e-04 NA 2.7e-03 NA 2.0e-05
9 GTEx Breast Mammary Tissue 0.333 0.0740 1.1e-06 0.044 NA 0.053 NA 0.053 2.6e-03 NA 1.1e-03 NA 1.1e-03
10 GTEx Breast Mammary Tissue (Female) 0.220 0.0978 2.4e-02 -0.005 NA -0.006 NA 0.009 4.7e-01 NA 5.6e-01 NA 1.7e-01
11 GTEx Colon Transverse 0.351 0.0750 2.1e-08 0.215 NA 0.157 NA 0.205 1.5e-10 NA 6.1e-08 NA 4.4e-10
12 GTEx Esophagus Mucosa 0.208 0.0490 8.6e-09 0.191 NA 0.163 NA 0.175 8.2e-13 NA 5.2e-11 NA 7.8e-12
13 GTEx Liver 0.397 0.0890 5.6e-06 0.333 NA 0.340 NA 0.336 4.7e-10 NA 2.8e-10 NA 3.7e-10
14 GTEx Lung 0.158 0.0438 8.7e-06 0.064 NA 0.074 NA 0.065 1.2e-05 NA 2.5e-06 NA 1.1e-05
15 GTEx Pancreas 0.592 0.0700 2.1e-15 0.261 NA 0.345 NA 0.348 2.0e-11 NA 2.5e-15 NA 1.8e-15
16 GTEx Pituitary 0.537 0.0770 1.1e-08 0.142 NA 0.323 NA 0.302 2.1e-04 NA 6.8e-09 NA 2.6e-08
17 GTEx Prostate 0.305 0.0840 2.0e-04 0.318 NA 0.264 NA 0.276 9.3e-09 NA 2.5e-07 NA 1.3e-07
18 GTEx Small Intestine Terminal Ileum 0.566 0.1040 1.8e-05 0.307 NA 0.091 NA 0.188 1.3e-07 NA 4.6e-03 NA 5.4e-05
19 GTEx Stomach 0.379 0.0740 5.1e-11 0.289 NA 0.265 NA 0.266 2.9e-14 NA 4.7e-13 NA 4.4e-13
20 GTEx Testis 0.457 0.0640 3.3e-15 0.346 NA 0.336 NA 0.360 3.9e-16 NA 1.3e-15 NA 7.5e-17
21 GTEx Thyroid 0.255 0.0460 6.8e-14 0.172 NA 0.171 NA 0.184 4.0e-13 NA 4.6e-13 NA 4.8e-14
22 GTEx Whole Blood 0.139 0.0340 8.2e-09 0.156 NA 0.151 NA 0.150 2.9e-14 NA 7.6e-14 NA 9.2e-14
23 METSIM Adipose 0.168 0.0301 0.0e+00 0.204 0.214 0.225 0.218 0.220 8.4e-30 2.4e-31 3.7e-33 4.8e-32 2.5e-32

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
Bipolar Disorder (2018) 0.8 1.3 5.6 -1.1 -0.6 -1.2 -1.0 0.3 0.6 -0.4 -1.0 -0.1 -0.8 -1.0 -1.0 -1.4 -2.0 -1.2 -2.4 -1.0 -1.3 -0.9 -1.3 -1.3 -1.2 -0.7
Bipolar Disorder or Schizophrenia 0.2 0.4 2.6 0.2 0.6 -0.1 -0.0 -1.6 -1.2 -0.6 0.3 0.3 -0.8 0.3 0.3 -0.3 -0.8 0.3 -0.6 0.6 0.2 0.3 0.3 -0.2 0.5 1.2
Depressed Affect (Nagel 2018) 1.8 3.9 5.6 2.0 2.0 2.1 1.9 -1.4 -2.2 0.9 1.9 1.4 2.1 2.0 2.1 2.3 1.6 2.1 2.2 2.1 1.9 2.0 1.9 1.9 2.2 2.4
Depression (Nagel 2018) 0.2 0.4 2.1 0.7 0.5 -0.1 1.0 -0.6 -0.4 -0.7 0.4 -0.9 -1.4 0.4 0.2 -0.4 0.5 0.0 -0.6 0.3 0.5 0.3 0.7 0.4 0.2 0.4
Intelligence (Savage-Jansen 2018) 1.4 4.3 6.0 2.4 2.1 1.9 1.4 -2.0 -1.9 1.9 2.1 2.2 0.9 2.2 2.1 2.3 2.0 2.4 2.4 2.1 2.1 2.1 2.0 2.1 2.4 2.2
Neuroticism (Nagel 2018) 0.6 1.5 2.8 1.7 1.7 1.1 1.4 -1.0 -1.5 0.8 1.3 0.5 1.2 1.3 1.2 1.2 0.8 1.5 0.7 1.1 1.0 1.2 1.2 1.1 1.3 1.4
Schizophrenia (2018) 0.7 1.5 4.7 1.2 1.3 0.8 0.8 -2.2 -1.8 -0.4 1.2 0.3 -0.4 1.3 1.1 0.8 0.3 1.4 1.0 1.6 1.3 1.2 1.4 0.8 1.6 2.1
Schizophrenia vs Biploar Disorder 2.2 2.9 4.6 2.0 1.8 1.7 1.9 -0.4 -1.2 0.9 2.0 1.6 0.6 2.1 2.1 1.6 1.9 1.4 2.1 2.0 2.1 0.0 1.7 2.1 1.7 1.5
Worry (Nagel 2018) 0.1 0.3 1.4 0.7 0.7 0.2 0.4 -1.2 -1.0 0.3 0.3 0.6 0.8 0.5 0.3 0.2 0.3 0.8 -0.2 0.4 0.2 0.3 0.4 0.2 0.4 0.6
Alzheimer’s Disease (in mother) 0.5 0.5 1.1 -0.8 -0.8 -0.9 -0.5 0.2 0.6 -1.0 -0.6 0.7 -0.4 -0.7 -0.7 -0.8 -0.8 -1.1 -0.8 -0.7 -0.9 -0.6 -0.5 -0.8 -0.8 -0.3
Alzheimer’s Disease (in father) 1.6 1.7 4.2 1.3 1.4 1.1 0.8 -0.5 -1.0 -0.1 1.6 1.1 0.4 1.5 1.5 1.2 1.0 1.3 1.8 1.6 2.1 1.5 1.4 1.4 1.4 1.6
Alzheimer’s Disease (including proxy) 0.3 0.5 2.0 0.6 0.6 0.4 0.4 0.1 -0.4 -0.2 0.9 1.4 0.0 0.9 0.9 0.4 0.0 0.2 0.6 0.8 0.9 0.9 0.7 0.7 0.7 0.8
Crohns Disease (2017) 0.4 0.8 4.3 0.4 0.4 0.5 -0.2 -0.5 -1.2 -1.1 0.6 1.0 1.0 0.6 0.6 1.2 -0.1 0.7 1.6 0.9 0.8 0.6 0.6 0.3 0.7 2.1
Irritable Bowel Disease (IBD) 0.1 0.3 2.2 -0.1 0.3 0.2 -0.8 0.2 -0.8 -0.6 0.3 0.7 0.8 0.2 0.3 0.7 -0.8 0.3 0.7 0.5 0.2 0.4 0.2 -0.1 0.2 1.5
Ulcerative Colitis (UC) 0.1 0.1 0.9 -0.2 0.3 0.1 -0.8 0.6 -0.4 -0.0 0.1 0.2 0.1 0.1 0.2 0.1 -0.9 0.1 -0.5 0.3 -0.1 0.2 -0.0 -0.2 -0.1 0.6
Major Depression (MDD) 0.2 0.2 0.9 -0.4 -0.2 -0.0 -0.7 0.7 -0.0 -0.1 -0.2 0.5 0.6 -0.2 0.0 -0.4 -0.9 -0.6 -0.1 -0.2 -0.1 0.0 -0.7 -0.4 -0.5 -0.3
Reaction Time 0.8 1.5 6.8 1.1 0.9 0.2 1.1 -2.6 -1.5 -1.2 1.1 -0.7 -0.9 1.1 1.1 0.2 1.0 0.9 1.2 1.3 1.3 1.0 1.4 0.8 1.1 2.2
Verbal and Numeric Reasoning (VNR) 1.2 2.9 5.0 1.9 1.5 1.7 1.0 -2.2 -2.0 1.2 1.7 1.8 0.3 1.7 1.7 1.9 1.6 1.9 2.0 1.8 1.7 1.6 1.6 1.5 2.0 2.0
Breast Cancer 3.1 7.6 11.8 3.4 2.8 2.8 3.4 -1.1 -1.8 1.1 3.1 2.5 1.4 3.2 3.2 2.8 2.9 2.7 2.8 3.0 3.1 3.2 3.0 3.3 2.9 2.2
Ovarian Cancer 0.3 0.4 1.3 0.6 0.7 0.3 1.1 0.7 0.2 0.8 0.7 -0.1 0.2 0.6 0.6 0.7 0.4 0.7 0.3 0.6 0.9 0.6 0.8 0.8 0.5 0.5
Prostate Cancer 0.5 0.7 3.4 -0.7 -0.7 -0.5 -0.4 1.1 1.1 -0.7 -0.7 0.6 1.8 -0.6 -0.5 0.1 -1.0 -0.8 -0.9 -0.8 -0.6 -0.8 -0.9 -0.6 -0.9 -1.1
Age at First Birth 1.0 1.4 2.8 1.4 1.6 0.9 1.4 -1.7 -1.5 0.3 1.4 0.4 -1.1 1.4 1.3 0.4 0.8 0.8 0.4 1.5 1.1 1.4 1.3 1.3 1.0 1.1
Bipolar Disorder (2011) 0.2 0.2 2.2 0.0 -0.5 -0.3 0.1 0.2 0.3 1.5 -0.3 0.3 0.5 -0.3 -0.4 0.1 -0.3 0.3 0.2 -0.2 -0.2 0.0 -0.0 -0.4 -0.1 0.5
Body Mass Index (BMI) (2010) 0.2 0.3 1.4 -0.4 -0.3 -0.4 -0.2 1.1 0.7 0.4 -0.5 -0.5 0.4 -0.5 -0.5 -0.2 -0.5 -0.3 -0.5 -0.6 -0.6 -0.4 -0.5 -0.4 -0.6 -1.2
Coronary Artery Disease (CAD) 5.3 6.3 9.7 2.8 2.9 2.3 3.1 -1.2 -1.5 2.7 2.9 1.1 0.7 2.8 2.8 2.6 2.7 2.9 1.7 2.9 2.6 3.0 2.8 2.8 2.6 2.3
Crohns Disease (2012) 0.2 0.4 1.7 -0.5 -0.8 -0.9 -1.0 0.4 0.3 -0.3 -0.6 0.1 0.1 -0.6 -0.6 -0.0 -1.3 -0.5 -0.0 -0.4 -0.8 -0.5 -0.6 -0.8 -0.5 0.7
Mean Putamen Volume 0.7 0.7 2.1 -0.9 -0.8 -0.9 -1.5 0.4 0.4 -0.1 -1.1 -0.1 -0.1 -1.0 -1.1 -0.8 -1.2 -0.6 -0.8 -0.9 -0.7 -1.1 -1.0 -1.3 -0.6 -0.5
Fasting Glucose 0.8 1.0 2.8 -0.0 0.8 1.1 0.6 -0.7 -1.4 0.1 0.8 0.8 1.7 0.8 0.8 1.3 0.7 1.3 1.3 1.0 1.0 0.6 1.0 0.6 1.2 1.5
HbA1C 0.3 0.3 0.9 -0.3 -0.1 -0.9 -0.6 0.5 0.8 0.1 -0.7 -0.2 0.2 -0.3 -0.7 -0.5 -0.2 -0.2 -0.1 -0.6 -0.5 -0.7 -0.6 -0.8 -0.5 -0.6
HDL Cholesterol 1.3 2.1 7.8 1.5 1.5 1.5 1.6 -1.1 -0.9 -0.1 1.2 1.1 0.2 1.2 1.4 1.3 2.3 1.6 2.8 1.1 1.2 1.2 1.5 1.7 1.7 1.3
LDL Cholesterol 0.3 0.5 2.2 -0.4 -0.4 -0.5 -1.0 0.5 0.2 -0.4 -0.4 -0.3 -0.8 -0.4 -0.4 -0.7 -1.0 -1.0 -1.5 -0.4 -0.3 -0.3 -0.7 -0.4 -0.9 -0.7
Lupus 0.6 0.9 3.6 -0.9 -0.5 -0.6 -0.4 1.3 1.5 -0.2 -0.9 -0.2 -1.9 -0.8 -1.0 -1.3 0.7 -0.8 -0.6 -1.1 -0.9 -0.8 -0.7 -0.3 -0.7 -1.4
Neuroticism (2016) 0.2 0.3 1.1 -0.6 -0.5 -0.0 -0.5 0.4 0.1 -1.0 -0.6 -0.6 0.5 -0.6 -0.5 0.1 -0.3 -0.1 -0.1 -0.5 -0.5 -0.8 -0.5 -0.6 -0.2 0.1
Primary Biliary Cirrhosis 0.3 0.5 0.9 0.5 1.0 0.4 0.8 0.4 -0.3 -0.3 0.6 0.6 0.3 0.6 0.6 0.8 0.9 0.9 0.7 0.7 0.7 0.6 0.8 0.8 0.8 0.6
Rheumatoid Arthritis 1.3 1.8 4.0 1.4 1.2 1.5 0.6 -1.5 -2.0 1.4 1.3 0.7 0.8 1.4 1.5 1.0 0.4 1.3 2.0 1.5 1.3 1.4 1.2 1.1 1.2 1.6
Schizophrenia (2014) 0.2 0.3 2.3 0.3 0.7 -0.5 0.0 -0.5 -0.4 -1.5 0.4 -0.0 -1.0 0.5 0.3 -0.4 -0.9 0.1 -0.6 0.6 0.2 0.4 0.2 -0.0 0.4 0.6
Triglycerides 3.2 5.3 8.7 2.4 2.3 2.3 2.4 -2.4 -2.9 1.1 2.5 1.9 1.2 2.6 2.5 2.0 1.7 2.4 1.5 2.7 3.0 2.5 2.4 2.2 2.3 2.4
Type 2 Diabetes (T2D) (2012) 2.0 2.3 4.5 -1.6 -1.3 -1.7 -1.7 1.1 1.2 -1.4 -1.8 -0.5 0.4 -1.8 -1.7 -1.3 -1.9 -1.4 -1.4 -1.6 -2.1 -1.7 -1.9 -1.9 -1.2 -0.5
Ulcerative Colitis 0.5 0.7 2.9 -1.0 -0.5 -0.7 -0.5 1.7 1.4 0.2 -0.7 -0.5 -0.3 -0.7 -0.6 -0.5 -0.7 -0.7 -1.2 -0.6 -1.3 0.0 -0.8 -0.7 -0.9 -0.9
Blood Eosinophil Count 1.7 13.3 26.8 -3.7 -3.4 -3.1 -3.8 2.9 3.3 0.3 -3.9 -3.6 0.3 -4.0 -3.5 -3.2 -5.2 -3.9 -3.1 -4.0 -3.6 -4.1 -4.3 -3.8 -4.8 -4.2
Blood Platelet Count 0.1 1.1 3.5 0.8 0.4 1.1 0.3 -0.6 -0.1 1.5 0.8 1.9 1.8 0.8 1.0 1.2 0.3 0.7 1.8 0.8 1.1 0.7 0.6 0.8 0.6 1.3
Blood Red Count 0.0 0.3 2.6 0.3 0.8 -0.0 -0.5 -0.4 -0.5 1.1 0.2 1.6 0.6 0.3 0.3 0.2 -0.6 0.1 -0.1 0.2 0.5 0.2 0.0 -0.0 -0.0 -0.4
Blood White Count 4.3 31.9 54.0 -5.8 -5.5 -4.4 -5.9 4.7 5.1 -2.4 -6.1 -5.4 -2.1 -6.0 -5.7 -5.8 -7.3 -6.5 -4.8 -6.2 -6.0 -6.2 -6.6 -5.8 -6.8 -6.0
Heel T-Score 0.0 0.3 2.3 -0.2 -0.0 -0.0 -1.5 -0.5 -0.6 1.0 -0.1 0.9 0.0 -0.0 -0.1 -0.1 -1.2 -0.4 0.2 0.1 -0.3 -0.0 -0.6 -0.4 -0.1 -0.3
BMI 0.3 1.5 2.8 -1.1 -1.0 -1.3 -1.3 1.6 1.6 -0.8 -1.2 -0.4 -0.2 -1.1 -1.0 -1.3 -1.5 -1.7 -0.9 -1.3 -1.7 -1.0 -1.5 -1.1 -1.3 -1.2
Height 0.5 10.3 17.0 -3.6 -3.4 -3.4 -3.2 2.3 2.9 -0.4 -3.5 -2.3 -1.1 -3.4 -3.6 -2.9 -3.8 -3.5 -4.1 -3.3 -3.4 -3.4 -3.6 -3.7 -3.6 -3.0
Waist Hip Ratio (WHR) 1.2 5.3 10.2 2.7 2.0 2.3 2.4 -1.9 -1.5 0.7 2.4 2.1 1.0 2.4 2.5 1.9 3.1 2.1 3.2 2.3 2.6 2.4 2.4 2.8 2.4 2.0
Systolic Blood Pressure 0.4 1.8 7.9 -0.7 -1.0 -1.2 -0.7 2.8 2.4 -0.0 -1.0 -0.7 -0.9 -1.0 -0.9 -1.6 -1.3 -1.4 -1.4 -1.3 -0.8 -1.1 -1.2 -0.6 -1.3 -2.4
Smoking Status 0.2 0.4 1.1 0.6 0.4 0.6 1.0 -0.3 -0.4 0.2 0.6 0.7 0.8 0.5 0.6 0.8 1.1 0.8 0.6 0.6 0.7 0.5 0.9 0.5 0.6 0.8
Allergy or Eczema 0.1 0.1 1.0 -0.0 -0.2 -0.2 0.4 -0.4 0.2 0.7 -0.1 -1.0 0.0 -0.1 -0.3 0.1 -0.1 0.6 -0.6 0.0 -0.4 0.1 0.1 -0.1 0.3 -0.3
Cardiovascular Disease 0.1 0.2 1.9 -0.0 0.1 -0.1 0.6 0.5 0.1 0.3 0.0 -0.3 1.4 0.1 0.1 0.5 0.5 0.8 0.3 0.1 -0.1 0.0 0.2 0.1 0.4 0.9
Hypothyroidism (self reported) 0.2 0.5 2.9 0.3 0.6 -0.7 -0.4 -1.5 -1.0 -1.2 0.1 -0.6 -1.7 -0.1 -0.2 -0.8 -0.6 -0.3 -0.8 0.2 0.1 0.0 0.1 -0.3 -0.3 0.1
Respiratory disease 0.5 1.2 3.0 -0.9 -1.0 -1.1 -1.0 1.1 1.0 0.2 -1.1 -1.1 -0.1 -1.1 -1.0 -0.9 -1.7 -1.2 -1.2 -1.2 -1.0 -1.1 -1.2 -1.1 -1.5 -1.4
Type 2 Diabetes (T2D) (2018) 0.0 0.1 0.5 0.4 0.2 0.1 0.5 0.5 0.3 0.2 0.3 -0.3 0.4 0.3 0.2 0.7 0.0 0.0 -0.1 0.2 0.1 0.3 0.1 0.3 -0.1 -0.2
Lung FEV1/FVC ratio 0.3 1.5 3.1 1.5 1.2 0.6 1.5 -0.5 -0.4 0.6 1.4 -0.2 0.2 1.3 1.2 1.2 1.2 1.5 1.4 1.4 1.6 1.4 1.8 1.3 1.0 1.2
Lung FVC 0.5 2.5 9.6 1.2 1.5 1.9 0.5 -1.8 -2.1 0.8 1.5 3.1 0.5 1.5 1.6 1.2 1.3 1.3 1.9 1.6 1.2 1.6 1.4 1.3 1.8 1.7
Neuroticism 1.1 2.6 5.2 1.8 1.9 1.6 1.3 -1.5 -2.3 0.2 1.5 1.3 1.8 1.7 1.6 1.7 1.4 1.8 1.5 1.7 1.5 1.6 1.4 1.5 1.8 1.9
Chronotype (morning person) 0.1 0.3 2.0 0.5 0.3 -0.1 1.4 0.6 0.6 1.3 0.3 -0.7 0.5 0.2 0.2 0.6 -0.2 0.7 -0.4 0.3 0.5 0.2 0.6 0.3 -0.0 0.1
Hair Pigment 0.0 1.0 2.5 -0.7 -1.0 -0.6 -0.5 1.4 1.6 0.7 -1.0 -1.5 -0.3 -1.0 -0.9 -0.9 -0.6 -0.9 -0.6 -1.1 -0.9 -1.1 -1.0 -0.7 -1.2 -1.2
Tanning 0.1 1.7 3.1 -1.5 -1.6 -1.4 -1.8 -0.4 0.4 -0.0 -1.3 -1.0 -1.4 -1.4 -1.5 -1.4 -1.6 -1.2 -1.4 -1.3 -1.4 -1.2 -1.2 -1.5 -1.4 -0.9
Hand grip strength (left) 0.7 1.9 3.8 -1.6 -0.9 -0.8 -1.9 1.8 1.6 0.7 -1.5 0.1 -0.7 -1.4 -1.3 -1.4 -1.7 -1.2 -0.6 -1.5 -1.9 -1.4 -1.5 -1.4 -1.3 -1.6
Number of treatments/medications taken 0.1 0.2 1.6 -0.1 -0.2 -0.3 0.6 1.3 0.1 -0.1 -0.3 -0.2 0.6 -0.1 -0.1 -0.2 0.7 0.2 0.1 -0.2 -0.4 -0.3 -0.1 -0.0 0.1 0.3
Average weekly spirits intake 0.2 0.3 0.9 -0.6 -0.6 0.0 -0.9 1.0 -0.1 0.2 -0.4 1.0 0.3 -0.3 -0.2 -0.3 -0.6 -0.6 0.7 -0.3 -0.3 -0.5 -0.7 -0.4 -0.3 0.0
Sensitivity / hurt feelings 0.1 0.2 0.8 0.4 0.3 0.2 0.5 -0.4 -0.9 0.3 0.1 -0.8 0.7 0.1 0.1 0.2 0.3 0.7 0.1 0.4 -0.1 0.0 0.2 0.0 0.5 0.6
Frequency of depressed mood in last 2 weeks 0.1 0.2 2.3 0.3 0.4 0.2 0.2 0.0 -0.6 -1.5 0.1 -0.5 -0.0 0.1 0.1 -0.3 -0.2 -0.3 -0.6 0.0 -0.0 -0.0 -0.0 0.2 0.0 -0.0
Hearing difficulty/problems: Yes 0.1 0.2 1.2 -0.3 -0.4 -0.4 -0.3 1.1 0.4 0.7 -0.4 -0.4 -0.2 -0.3 -0.4 -0.1 -0.1 -0.2 -0.3 -0.4 -0.6 -0.2 -0.4 -0.4 -0.4 -0.4
Relative age of first facial hair 1.1 2.2 4.2 1.3 1.2 0.9 1.5 -0.8 -0.9 1.9 1.4 1.7 0.5 1.5 1.3 1.5 1.8 2.0 1.6 1.5 1.5 1.5 1.9 1.4 1.6 1.7
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 1.8 -0.6 -0.4 -0.3 -0.1 1.1 0.4 0.9 -0.6 -0.2 1.3 -0.5 -0.3 0.0 -0.0 0.0 0.6 -0.5 -0.6 -0.5 -0.4 -0.4 -0.3 -0.3
Ever used hormone-replacement therapy (HRT) 1.1 1.4 4.5 1.0 0.9 0.6 0.8 -1.9 -1.7 0.6 1.1 -0.1 -0.3 1.2 1.1 0.8 0.6 1.4 1.3 1.4 1.1 1.1 1.6 0.8 1.2 2.1
Ever had hysterectomy (womb removed) 0.3 0.3 2.4 0.0 0.3 0.1 0.5 0.2 -0.6 -1.5 0.0 0.4 1.5 0.2 0.1 0.8 0.0 0.5 -0.4 0.2 0.2 -0.0 0.2 -0.0 0.1 0.6
Systolic blood pressure, automated reading 1.6 4.6 9.4 -1.8 -2.0 -2.0 -1.6 3.1 2.8 -1.4 -2.1 -1.5 -0.9 -1.9 -2.0 -2.3 -2.3 -2.5 -2.5 -2.3 -2.0 -2.0 -2.3 -1.9 -2.3 -2.8
Eye problems/disorders: Diabetes related eye disease 0.9 1.0 2.6 0.7 0.9 0.6 0.8 -0.0 -0.7 -0.5 1.2 0.4 1.4 1.2 1.2 1.5 1.0 1.0 0.6 1.2 1.1 1.2 0.9 1.1 1.1 1.6
Angina 3.2 4.2 7.2 1.9 1.7 1.9 1.9 -1.2 -2.0 1.6 2.0 2.4 2.4 2.1 2.1 2.4 2.3 2.3 1.6 2.2 1.8 2.1 1.9 1.9 2.4 2.7
Medication for hormone replacement therapy 2.0 2.2 3.4 -1.7 -1.8 -1.5 -1.8 1.8 1.7 -0.1 -1.8 -0.6 0.0 -1.7 -1.6 -1.4 -1.3 -1.6 -0.7 -1.6 -1.5 -1.8 -1.8 -1.6 -1.6 -0.9
Vitamin and mineral supplements 1.2 1.6 3.1 -1.4 -1.2 -1.8 -1.5 1.1 1.1 -1.0 -1.3 -1.5 -0.2 -1.3 -1.2 -1.0 -1.4 -1.3 -0.7 -1.3 -1.4 -1.3 -1.2 -1.5 -1.6 -0.5
Supplements: Zinc 0.1 0.1 1.0 -0.0 0.2 0.5 -0.3 -0.6 -0.5 1.0 0.0 0.1 -0.2 0.0 -0.0 0.0 -0.2 0.2 -0.3 0.1 -0.1 0.1 -0.2 0.1 0.3 -1.0
Medication: Co-codamol 1.0 1.1 4.7 1.1 1.0 0.6 2.2 0.0 0.0 1.5 0.9 -0.7 -1.2 0.9 0.7 0.5 1.9 1.3 0.0 0.8 1.1 0.9 1.4 1.1 1.0 0.4
Medication: Metformin 0.2 0.3 0.7 -0.7 -0.7 -0.4 -0.6 0.8 0.5 -0.2 -0.6 -0.5 0.8 -0.6 -0.6 0.2 -0.3 -0.3 0.1 -0.5 -0.7 -0.6 -0.7 -0.6 -0.4 -0.0
Diabetes (father) 0.2 0.3 1.3 0.1 -0.2 -0.1 -0.3 0.9 0.7 -0.4 -0.2 0.5 -0.0 -0.3 -0.2 -0.7 -0.6 -0.6 -1.1 -0.4 -0.1 -0.3 -0.4 -0.2 -0.7 -0.8
Diabetes (mother) 1.3 1.7 3.5 -1.4 -1.2 -0.8 -1.8 1.0 0.9 -0.3 -1.5 -1.2 -0.5 -1.4 -1.3 -1.5 -1.5 -1.6 0.1 -1.4 -1.4 -1.5 -1.9 -1.3 -1.1 -1.5
Severe depression (siblings) 0.8 0.9 2.5 -0.5 -1.1 -0.9 -1.2 -0.1 -0.0 1.6 -0.8 -1.5 -0.8 -0.9 -1.0 -0.6 -1.5 -0.6 -0.8 -0.6 -0.5 -1.0 -0.6 -1.1 -0.6 -0.9
Pack years adult smoking proportion 1.4 2.2 3.7 1.4 1.4 1.9 1.4 -0.4 -1.0 -0.8 1.4 1.8 1.8 1.5 1.7 1.8 1.6 1.1 1.8 1.4 1.5 1.4 1.1 1.7 1.4 1.2
Impedance of leg (right) 1.9 9.3 16.0 3.6 2.7 3.1 4.0 -1.3 -1.7 0.5 3.4 2.4 1.6 3.3 3.3 3.5 3.7 3.3 2.8 3.3 3.7 3.4 3.5 3.6 3.4 2.0
Leg fat-free mass (left) 2.2 11.4 17.1 -3.9 -3.2 -3.3 -4.0 2.7 2.9 -0.5 -3.9 -1.8 -0.7 -3.8 -3.6 -3.5 -4.1 -3.7 -2.4 -3.8 -4.1 -3.8 -4.1 -3.9 -3.7 -2.9
Trunk fat percentage 0.9 3.6 6.0 -1.9 -1.9 -1.9 -1.4 2.0 2.2 -1.8 -2.0 -1.3 -0.4 -1.9 -1.8 -2.2 -1.8 -2.5 -1.2 -2.0 -2.2 -1.9 -2.2 -1.9 -2.1 -2.0
Hand grip strength (right) 0.3 0.7 1.9 -1.0 -0.4 -0.1 -1.4 0.8 0.8 -0.4 -0.8 0.1 -1.2 -0.7 -0.7 -1.0 -1.2 -0.9 0.2 -0.9 -1.2 -0.7 -0.9 -0.6 -0.6 -0.8
Townsend deprivation index at recruitment 0.1 0.2 1.3 0.2 -0.1 0.1 0.4 0.3 -0.0 0.3 0.3 0.4 1.1 0.1 0.1 0.7 0.2 0.5 0.2 0.4 -0.0 0.3 0.2 0.1 0.6 0.3
Current tobacco smoking 0.1 0.1 0.7 0.1 -0.1 0.4 0.6 0.1 -0.1 0.1 0.2 0.1 0.7 0.0 0.2 0.6 0.9 0.6 0.4 0.2 -0.2 0.2 0.5 0.2 0.3 0.5
Average weekly fortified wine intake 0.1 0.1 0.5 -0.1 0.0 -0.0 -0.1 0.6 0.3 -0.7 -0.0 -0.3 0.4 -0.1 -0.0 0.0 -0.1 0.1 -0.7 0.0 -0.4 -0.1 -0.1 -0.2 0.0 0.1
Maternal smoking around birth 0.4 0.6 1.6 -0.7 -0.8 -1.0 -0.9 0.8 0.5 -0.6 -0.9 -0.0 0.2 -0.8 -0.9 -0.7 -1.2 -0.8 -0.5 -0.7 -0.4 -0.9 -0.8 -1.2 -0.9 -0.3
Fed-up feelings 0.4 0.7 2.0 0.8 0.9 1.1 0.8 -0.5 -1.3 -0.7 0.7 0.8 1.3 0.7 0.8 1.0 0.4 0.8 1.0 0.9 0.5 0.6 0.7 0.6 0.8 1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.6 -0.1 -0.4 -0.8 -0.1 0.4 -0.1 0.2 -0.3 -0.7 -0.4 -0.3 -0.5 -0.4 0.1 0.0 0.1 -0.2 -0.4 -0.4 0.1 -0.5 0.1 0.5
Relative age voice broke 0.1 0.2 1.0 0.2 0.1 -0.1 -0.4 -0.8 -0.6 -0.3 0.2 1.0 -0.4 0.3 0.1 -0.0 -0.4 0.4 0.4 0.3 0.5 0.2 0.5 -0.0 0.2 1.0
Taking other prescription medications 0.5 0.8 3.3 -0.9 -0.8 -0.9 -0.3 1.8 1.1 -0.3 -1.1 0.4 0.9 -0.9 -0.9 -0.7 -0.2 -0.6 -0.6 -1.1 -1.3 -0.9 -1.0 -0.9 -0.9 -0.9
Age when periods started (menarche) 0.1 0.1 0.8 -0.1 0.0 0.2 0.2 0.9 0.5 0.2 0.1 -0.2 -0.6 0.1 0.1 -0.3 0.4 -0.2 0.6 -0.1 -0.1 0.0 0.1 0.3 -0.2 -0.6
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 2.4 -0.8 -0.4 0.1 -0.8 0.1 -0.2 -1.0 -0.8 0.9 1.6 -0.7 -0.5 0.0 -0.2 0.0 0.4 -0.6 -0.6 -0.8 -0.8 -0.6 -0.3 -0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.9 0.0 -0.7 0.3 -1.0 -0.9 -0.6 -0.0 -0.0 0.8 -0.9 -0.0 0.0 -0.6 -0.5 -0.6 0.8 -0.0 -0.1 0.1 -0.3 -0.2 -0.0 -0.4
Tinnitus: Yes, but not now, but have in the past 0.9 1.0 2.8 0.9 1.0 0.9 0.8 0.3 -0.3 1.7 1.2 1.1 0.6 1.2 1.3 0.8 1.1 0.6 0.6 1.1 1.4 1.1 0.7 1.3 0.9 0.5
Qualifications: CSEs or equivalent 0.4 0.5 1.2 -0.7 -0.8 -0.3 -1.1 0.9 0.3 0.8 -0.7 0.9 0.7 -0.7 -0.6 -0.3 -1.1 -0.7 0.4 -0.6 -0.9 -0.5 -0.9 -0.9 -0.5 -0.6
Serious illness, injury or assault to yourself 0.3 0.3 2.8 0.3 0.3 0.7 0.3 0.0 -0.4 0.1 0.4 0.8 1.7 0.5 0.7 0.7 0.2 0.1 1.0 0.6 0.1 0.6 0.0 0.3 0.5 0.3
High blood pressure 0.7 2.0 4.0 -1.5 -1.3 -1.5 -1.1 1.8 1.3 -1.0 -1.5 -1.5 0.3 -1.4 -1.5 -1.2 -1.6 -1.0 -2.0 -1.5 -1.9 -1.5 -1.5 -1.6 -1.2 -1.0
Hayfever, allergic rhinitis or eczema 0.0 0.1 0.8 -0.0 -0.2 0.1 0.2 -0.9 -0.5 0.8 -0.1 -0.5 -0.2 -0.1 -0.2 -0.1 -0.0 0.5 -0.1 0.1 -0.1 0.1 0.0 -0.1 0.2 -0.2
Multivitamins +/- minerals 0.2 0.2 0.7 0.4 0.4 0.8 0.3 0.0 -0.3 0.6 0.4 0.8 0.7 0.4 0.4 0.3 0.4 0.5 0.5 0.3 0.5 0.4 0.3 0.6 0.7 -0.3
Stomach or abdominal pain in last month 0.9 1.1 2.2 -0.9 -1.4 -0.8 -0.9 0.6 0.4 -0.3 -1.2 -0.7 -1.1 -1.2 -1.3 -1.3 -0.9 -1.2 -1.1 -1.2 -1.3 -1.0 -1.1 -1.1 -1.1 -1.5
Supplements: Glucosamine 3.0 3.9 7.7 2.0 1.9 1.7 1.6 -2.8 -2.5 0.2 2.3 1.4 -0.7 2.2 2.0 1.5 1.8 2.0 1.4 2.3 2.3 2.3 2.5 2.0 2.3 2.1
Diverticular disease/diverticulitis (self-reported) 0.2 0.3 1.5 0.7 0.1 0.6 0.7 0.9 0.5 1.2 0.5 -0.5 -0.4 0.5 0.4 0.2 0.1 0.2 -0.1 0.3 0.6 0.5 0.5 0.5 -0.0 -0.7
Medication: Atenolol 0.8 1.0 2.9 1.2 0.8 1.1 1.7 0.0 -0.6 -0.4 1.1 0.5 0.6 1.1 1.1 1.1 1.1 1.0 -0.3 1.1 0.9 1.2 1.1 1.3 1.2 1.0
Medication: Levothyroxine sodium 0.7 1.2 2.6 -1.0 -0.7 -1.6 -0.7 0.3 0.4 -1.1 -1.2 -1.0 -0.6 -1.3 -1.3 -1.4 -1.4 -1.0 -1.4 -1.0 -1.1 -1.3 -1.0 -1.6 -1.4 -0.6
Sitting height 0.8 5.5 8.0 -2.8 -2.5 -2.5 -2.6 1.6 2.1 -0.6 -2.7 -1.6 -0.7 -2.7 -2.7 -2.1 -2.7 -2.7 -1.3 -2.7 -2.6 -2.8 -2.6 -2.7 -2.7 -1.7
Chronic bronchitis/emphysema (father) 1.1 1.3 4.0 -0.8 -1.2 -1.2 -0.3 0.8 1.1 -1.6 -0.9 -1.9 -2.0 -1.0 -1.2 -1.4 -0.5 -0.9 -1.6 -1.0 -1.0 -1.0 -0.6 -0.8 -0.8 -1.1
High blood pressure (mother) 0.1 0.1 0.7 0.3 0.1 0.4 -0.1 -0.1 -0.7 0.8 -0.2 0.1 -0.4 -0.2 -0.2 -0.4 -0.3 0.1 -0.2 -0.2 -0.2 -0.1 -0.2 -0.1 -0.0 -0.8
Body mass index (BMI) 1.3 5.5 8.9 -2.4 -2.3 -2.3 -2.5 2.2 2.4 -1.2 -2.6 -1.7 -1.1 -2.4 -2.4 -2.8 -2.5 -2.8 -1.5 -2.6 -3.0 -2.5 -2.7 -2.5 -2.5 -2.1
Impedance of leg (left) 1.4 6.9 13.4 3.1 2.3 2.6 3.7 -1.3 -1.5 -0.1 3.0 1.8 0.7 2.9 2.8 2.8 3.4 2.7 2.1 2.9 3.3 3.0 3.1 3.1 3.0 1.8
Leg predicted mass (left) 2.2 11.5 17.3 -3.9 -3.3 -3.3 -4.0 2.7 2.9 -0.5 -3.9 -1.8 -0.6 -3.8 -3.7 -3.4 -4.1 -3.7 -2.5 -3.8 -4.2 -3.8 -4.1 -3.9 -3.7 -2.9
Trunk fat mass 1.9 8.2 12.1 -3.1 -2.9 -2.8 -2.7 3.0 3.1 -1.6 -3.2 -1.7 -0.4 -3.0 -2.9 -3.0 -3.0 -3.4 -2.0 -3.1 -3.5 -3.0 -3.4 -3.0 -3.2 -2.9
Waist circumference 1.3 4.7 7.7 -2.2 -2.2 -2.1 -2.1 2.6 2.6 -0.6 -2.4 -1.3 -0.0 -2.3 -2.2 -2.2 -2.1 -2.5 -1.1 -2.4 -2.8 -2.3 -2.7 -2.2 -2.3 -2.1
Number of incorrect matches in round 0.4 0.6 2.2 -1.0 -0.6 -1.3 -0.2 0.2 1.1 -0.7 -0.7 -1.2 -0.2 -0.7 -0.8 -0.5 -0.8 -0.6 -1.5 -0.7 -1.0 -0.8 -0.6 -0.8 -0.5 -0.3
Past tobacco smoking 0.1 0.2 0.6 0.3 0.2 0.3 0.7 -0.3 -0.4 0.4 0.4 -0.5 -0.7 0.4 0.2 0.3 0.5 0.8 0.0 0.5 0.3 0.4 0.6 0.5 0.6 0.6
Alcohol usually taken with meals 0.4 0.7 2.0 -1.0 -0.4 -0.8 -1.1 -0.5 -0.3 0.4 -1.0 -0.7 -0.1 -0.9 -1.2 -0.1 -1.2 0.2 -1.4 -0.7 -1.4 -0.7 -0.7 -1.2 -0.5 -0.1
Nervous feelings 0.5 0.9 3.5 -0.7 -0.5 -1.2 -0.6 -0.1 -0.0 -0.6 -1.1 -0.3 -0.4 -1.0 -1.2 -1.3 -0.5 -0.8 -1.9 -1.1 -1.4 -1.0 -1.0 -1.0 -1.0 -1.0
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.1 0.6 0.5 0.3 0.2 0.4 0.6 -0.3 0.3 0.3 -0.0 0.8 0.2 0.3 0.3 -0.3 0.2 0.2 0.3 -0.0 0.3 0.2 0.2 0.2 0.0
Hearing difficulty/problems with background noise 0.1 0.1 0.6 0.2 0.6 0.2 0.1 -0.2 -0.6 0.8 0.1 -0.1 -0.1 0.2 0.1 0.2 0.1 0.4 0.2 0.2 -0.0 0.3 -0.0 0.1 0.2 0.1
Hair/balding pattern: Pattern 2 0.2 0.2 1.1 -0.2 -0.1 0.1 0.6 0.8 1.0 -1.0 -0.2 0.0 1.0 -0.2 0.0 0.5 0.9 -0.2 0.3 -0.3 -0.2 -0.2 -0.2 0.3 -0.1 -0.3
Had menopause 1.0 1.2 4.6 0.9 1.0 0.8 1.9 -0.8 -0.7 -2.1 1.2 0.0 0.7 1.2 1.1 1.1 0.8 0.8 -0.1 1.2 1.2 1.1 1.3 1.0 0.8 1.1
Had other major operations 0.5 0.6 1.6 -0.8 -1.0 -0.7 -0.7 1.1 0.5 1.2 -0.8 0.1 0.7 -0.7 -0.6 -0.6 -0.7 -0.5 -0.8 -0.8 -0.8 -0.7 -0.9 -0.8 -0.6 -1.2
Forced vital capacity (FVC) 0.3 1.1 5.3 0.5 0.8 1.4 0.6 -0.7 -0.8 1.0 0.6 2.3 1.2 0.5 0.7 1.3 1.1 1.0 2.0 0.6 0.6 0.6 0.6 0.8 1.0 1.0
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.2 1.0 -0.1 -0.6 0.0 -1.0 -0.4 -0.2 -0.6 -0.2 0.9 -0.4 -0.1 -0.1 -0.4 -0.5 -0.8 0.6 -0.2 -0.4 0.0 -0.4 -0.2 -0.1 -0.5
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 1.9 -0.3 -0.0 -0.1 -0.6 1.3 0.4 -0.7 -0.2 0.2 0.4 -0.3 -0.1 -0.5 -0.9 -0.8 -0.6 -0.4 -0.1 -0.2 -0.8 -0.3 -0.5 -1.4
Qualifications: None of the above 1.1 2.4 7.8 -1.8 -1.4 -1.3 -1.1 0.9 0.9 -2.8 -1.7 -1.0 -0.0 -1.7 -1.4 -1.8 -1.6 -1.9 -0.8 -1.7 -1.7 -1.8 -1.8 -1.7 -1.9 -1.2
Financial difficulties in last 2 years 0.1 0.2 1.0 0.0 -0.2 0.3 -0.1 -0.1 -0.3 -0.2 -0.2 -0.5 -0.8 -0.2 -0.3 -0.2 1.0 0.1 0.9 -0.1 -0.4 -0.0 0.1 0.1 0.5 0.3
Mouth/teeth dental problems 2.4 3.7 7.0 -2.2 -2.2 -1.5 -2.5 0.9 0.9 0.5 -2.2 -2.6 -1.2 -2.2 -2.2 -1.7 -2.3 -1.7 -1.5 -2.1 -1.9 -2.1 -2.0 -2.1 -1.8 -1.9
Heart attack 0.5 0.6 1.7 0.6 0.6 0.4 0.9 -0.2 -1.3 -0.7 0.8 0.6 0.3 0.7 0.6 0.9 0.6 1.1 -0.1 1.0 0.7 0.7 1.0 0.6 1.1 1.3
Allergy 0.3 0.7 1.8 0.9 0.8 0.7 0.8 0.0 -0.3 -0.1 0.9 1.2 0.0 0.9 1.0 0.7 1.3 0.5 1.3 0.8 0.9 0.8 1.0 1.0 0.9 1.0
Pain all over the body in last month 0.2 0.2 0.8 -0.5 -0.4 -0.6 -0.5 0.2 0.5 0.6 -0.5 -0.7 -0.4 -0.6 -0.6 -0.9 -0.5 -0.2 0.2 -0.4 -0.4 -0.5 -0.4 -0.5 -0.3 -0.3
Diabetes (self-reported) 0.4 0.6 1.3 1.0 1.0 0.6 0.9 -0.9 -1.1 0.3 0.9 0.3 0.3 0.9 0.9 1.1 0.9 0.8 -0.1 0.9 0.5 0.9 0.7 0.8 0.7 0.7
Hayfever/allergic rhinitis (self-reported) 1.7 2.3 4.6 -1.5 -1.4 -1.5 -1.1 2.1 1.4 0.4 -1.8 0.1 0.7 -1.6 -1.6 -1.2 -0.9 -1.2 -1.3 -1.9 -2.0 -1.6 -1.8 -1.4 -1.6 -2.1
Medication: Ramipril 0.6 0.7 1.3 0.8 0.8 1.0 0.6 -0.4 -1.1 0.6 0.9 1.1 0.7 0.8 1.0 0.9 0.8 0.8 1.0 1.0 0.8 0.7 0.7 0.9 1.0 0.9
Medication: Simvastatin 0.9 1.3 3.7 1.0 1.7 1.1 1.4 -1.0 -1.9 0.3 1.2 -0.2 0.3 1.2 1.2 0.9 0.6 1.5 -0.2 1.4 1.0 1.1 1.2 0.9 1.2 1.4
Fluid intelligence score 0.8 1.7 4.0 1.4 0.9 1.1 0.6 -1.7 -1.1 1.5 1.2 0.6 0.2 1.2 1.2 1.7 1.1 1.7 2.0 1.4 0.9 1.2 1.3 1.0 1.7 1.9
Illnesses of siblings 0.1 0.1 0.8 -0.5 -0.1 -0.3 -0.9 -0.0 0.2 -0.6 -0.3 0.4 0.2 -0.4 -0.3 0.1 -0.5 -0.3 -0.3 -0.3 -0.2 -0.4 -0.5 -0.4 -0.3 -0.0
Neuroticism score 0.3 0.6 3.1 0.9 0.9 0.6 0.3 -1.1 -1.8 -0.5 0.7 0.2 0.5 0.7 0.6 0.5 0.2 0.7 0.3 0.8 0.5 0.7 0.5 0.5 0.8 1.2
Weight 2.5 12.2 18.0 -3.8 -3.5 -3.5 -3.7 3.2 3.5 -1.4 -3.9 -2.2 -1.0 -3.8 -3.7 -3.6 -3.9 -4.0 -2.5 -3.8 -4.2 -3.8 -4.1 -3.8 -3.8 -3.2
Impedance of arm (right) 0.6 2.9 8.0 1.9 1.5 1.6 2.8 -1.1 -1.3 -0.0 1.9 0.3 0.5 1.8 1.9 1.6 2.3 1.8 1.3 1.8 2.2 1.9 2.0 2.1 1.7 0.5
Arm fat percentage (right) 1.0 3.9 6.0 -2.0 -1.9 -2.0 -1.7 2.0 2.3 -1.1 -2.1 -1.8 -0.8 -2.0 -1.9 -2.4 -1.9 -2.4 -1.1 -2.1 -2.4 -2.0 -2.3 -1.9 -2.2 -2.2
Trunk fat-free mass 2.0 11.7 18.7 -4.0 -3.4 -3.5 -4.0 2.9 3.3 -0.1 -3.9 -1.9 -0.5 -3.9 -3.8 -3.2 -3.9 -3.5 -2.4 -3.8 -4.3 -3.9 -4.0 -3.9 -3.6 -2.7
Hip circumference 2.9 12.4 17.3 -3.8 -3.3 -3.5 -3.5 3.5 3.5 -0.8 -3.9 -2.7 -1.1 -3.8 -3.7 -3.7 -3.8 -3.9 -3.0 -3.9 -4.2 -3.9 -4.1 -3.8 -3.8 -3.8
Time employed in main current job 0.5 0.5 1.2 0.6 0.8 0.7 0.5 -0.5 -0.7 -0.6 0.8 0.3 -0.3 0.8 0.7 0.5 0.5 0.6 1.0 0.9 1.1 0.8 0.9 0.7 1.0 0.9
Alcohol intake versus 10 years previously 1.7 2.5 4.3 1.6 1.2 2.0 1.7 -1.3 -2.1 0.9 1.5 1.7 1.6 1.6 1.5 2.0 1.5 1.7 1.0 1.6 1.2 1.6 1.3 1.4 1.6 2.1
Father’s age at death 0.3 0.4 2.6 0.1 0.2 -0.1 0.4 -0.8 0.4 0.8 0.1 -1.1 -1.6 0.0 -0.2 -0.3 0.0 0.1 -1.4 -0.1 -0.2 0.1 0.2 0.2 -0.1 -0.8
Worrier / anxious feelings 0.3 0.6 1.5 1.0 1.2 0.4 0.8 -1.1 -1.0 0.1 0.8 0.0 -0.2 0.8 0.7 0.5 0.2 0.8 -0.7 0.9 0.5 0.9 0.8 0.5 0.6 1.0
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.4 1.5 -0.3 -0.5 -0.4 -0.0 1.0 0.4 0.5 -0.7 -0.5 1.2 -0.7 -0.6 0.1 0.3 0.2 0.5 -0.5 -1.2 -0.5 -0.6 -0.5 0.1 -0.1
Falls in the last year 0.9 1.2 3.4 -1.0 -0.8 -0.7 -1.2 1.8 1.6 -0.7 -0.9 -0.1 -0.1 -0.9 -0.8 -1.3 -1.1 -1.6 -0.4 -1.1 -0.9 -0.8 -1.4 -0.8 -1.1 -1.6
Hair/balding pattern: Pattern 3 0.1 0.1 0.6 -0.0 0.2 0.1 -0.3 -0.6 -0.6 0.6 0.3 0.0 -0.8 0.2 0.0 -0.2 -0.2 0.4 -0.5 0.3 0.5 0.2 0.3 -0.0 0.1 -0.1
Number of live births 2.3 3.2 5.3 -2.1 -2.1 -2.2 -2.2 1.8 2.0 0.5 -2.1 -0.6 0.5 -2.0 -1.9 -1.5 -1.5 -1.7 -0.5 -2.0 -2.3 -2.1 -2.1 -2.1 -1.8 -1.5
Forced expiratory volume in 1-second (FEV1) 0.6 1.9 5.6 1.2 1.3 1.7 0.9 -1.0 -1.1 1.2 1.0 2.4 1.3 1.0 1.1 1.7 1.3 1.5 2.4 1.1 1.2 1.0 1.1 1.2 1.4 1.4
Pulse rate 0.2 0.4 3.2 0.2 0.7 0.6 -0.3 -1.0 -0.9 -1.8 0.5 0.3 -0.8 0.5 0.4 0.0 -0.1 -0.1 -0.2 0.5 0.2 0.5 0.3 0.2 0.2 0.8
Happiness 0.5 0.7 2.5 -0.7 -0.5 -0.6 -0.9 0.3 0.2 -0.6 -0.8 -1.6 -0.6 -0.9 -0.9 -0.9 -1.3 -0.4 -0.9 -0.7 -0.9 -1.1 -0.6 -1.0 -0.5 0.5
Noisy workplace 0.6 0.7 1.6 -0.8 -0.4 -0.9 -0.7 1.3 1.0 -1.2 -0.7 -0.6 -0.7 -0.6 -0.7 -0.7 -0.4 -1.1 -1.3 -0.8 -0.9 -0.7 -0.8 -0.6 -0.9 -0.4
Qualifications: A levels/AS levels or equivalent 0.6 1.2 4.7 1.1 0.8 0.7 0.2 -1.3 -1.0 1.5 0.9 1.2 0.1 1.0 0.9 0.9 1.2 1.1 2.2 1.0 1.3 0.9 0.9 1.0 1.2 1.4
Serious illness, injury or assault of a close relative in last 2 years 2.0 2.3 8.6 1.7 1.6 1.4 1.1 -1.0 -1.1 2.9 1.5 1.7 0.8 1.6 1.5 1.6 1.4 1.6 1.2 1.5 1.2 1.7 1.2 1.6 1.5 1.1
Mouth/teeth dental problems: Dentures 0.3 0.6 3.0 -0.3 -0.1 -0.7 0.7 1.7 1.4 -0.2 -0.5 0.2 0.9 -0.5 -0.5 -0.3 -0.5 -0.6 -1.4 -0.6 -0.5 -0.6 -0.5 -0.5 -0.9 -0.9
Asthma 0.3 0.7 2.0 -0.8 -0.8 -0.5 -1.4 -0.1 -0.1 0.6 -0.8 -0.1 0.3 -0.7 -0.6 -0.8 -1.4 -0.9 -0.5 -0.8 -0.8 -0.8 -1.2 -0.9 -1.0 -1.1
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.5 -0.3 -0.3 -0.5 0.1 0.2 0.5 -1.2 -0.4 -1.0 -1.2 -0.5 -0.4 -1.1 -0.7 -0.8 -1.0 -0.5 -0.2 -0.5 -0.5 -0.4 -0.6 -0.9
Medication: Cholesterol lowering 0.4 0.6 1.9 0.5 0.5 0.5 0.9 -0.2 -1.0 -0.3 0.4 0.7 0.9 0.5 0.4 1.1 1.0 1.4 0.3 0.7 0.2 0.5 0.8 0.4 0.9 1.3
Depression (self-reported) 1.3 1.6 3.6 1.7 1.4 0.9 1.7 -0.1 -0.7 0.6 1.4 0.4 0.2 1.5 1.4 1.1 1.9 1.3 1.1 1.3 1.3 1.5 1.5 1.6 1.3 0.6
Medication: Lansoprazole 1.5 1.7 5.7 -1.1 -1.3 -0.9 -0.5 2.4 2.0 0.3 -1.5 -1.0 0.6 -1.4 -1.4 -0.8 -0.9 -0.9 -0.9 -1.6 -1.8 -1.4 -1.5 -1.1 -1.3 -1.6
Prospective memory result 0.6 0.7 2.1 -0.4 -0.3 -1.5 -0.2 1.1 1.5 0.5 -0.6 -1.3 -0.6 -0.7 -0.9 -0.8 -0.5 -0.4 -1.3 -0.7 -0.8 -0.6 -0.3 -0.6 -0.9 -1.0
Lung cancer (father) 1.9 2.2 4.2 -1.5 -1.8 -1.1 -0.8 1.5 1.5 -1.9 -1.5 -2.0 -1.6 -1.5 -1.6 -1.7 -1.0 -1.5 -0.8 -1.6 -1.4 -1.6 -1.2 -1.1 -1.5 -1.7
Illnesses of mother 0.2 0.3 1.2 0.2 -0.1 -0.4 0.7 0.7 0.7 -0.9 0.4 0.3 1.1 0.3 0.3 0.8 0.5 0.2 0.1 0.3 0.3 0.4 0.5 0.3 -0.0 1.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.8 3.1 0.7 0.7 1.1 0.6 -0.8 -0.5 0.3 0.7 1.7 0.2 0.6 0.7 0.8 1.0 0.8 1.8 0.7 0.9 0.7 0.8 0.8 1.0 1.2
Pulse wave Arterial Stiffness index 0.3 0.4 2.3 -0.2 0.2 0.1 -0.6 0.1 -0.1 -0.7 -0.5 -0.3 0.5 -0.4 -0.5 -0.3 -1.5 -0.1 -1.3 -0.4 -0.7 -0.4 -0.7 -0.5 -0.5 -1.1
Impedance of arm (left) 0.4 1.8 5.1 1.6 1.2 1.3 2.2 -0.8 -1.1 -0.1 1.5 0.5 0.6 1.4 1.5 1.3 1.9 1.3 0.9 1.3 1.9 1.4 1.5 1.7 1.2 0.2
Arm fat mass (right) 1.7 7.2 11.2 -2.9 -2.7 -2.7 -2.7 2.4 2.8 -1.3 -3.0 -2.0 -0.9 -2.8 -2.7 -3.0 -2.9 -3.1 -1.7 -2.9 -3.4 -2.8 -3.1 -2.8 -2.9 -2.7
Trunk predicted mass 2.0 11.3 17.9 -3.9 -3.4 -3.4 -4.0 2.9 3.2 -0.0 -3.9 -1.8 -0.5 -3.8 -3.7 -3.1 -3.9 -3.4 -2.4 -3.7 -4.2 -3.8 -3.9 -3.9 -3.6 -2.6
Standing height 0.8 8.4 12.2 -3.5 -2.9 -2.9 -3.0 2.6 2.7 -1.1 -3.3 -1.2 0.1 -3.4 -3.2 -2.4 -3.4 -3.0 -2.5 -3.2 -3.3 -3.4 -3.4 -3.3 -3.1 -2.7
Length of working week for main job 0.1 0.1 0.4 -0.2 0.1 0.2 0.0 -0.3 -0.6 -0.6 -0.2 -0.3 -0.7 -0.2 -0.4 0.1 0.1 0.3 -0.5 -0.0 0.2 -0.2 0.0 -0.2 0.2 0.5
Exposure to tobacco smoke at home 0.1 0.1 0.5 -0.1 0.1 0.3 -0.4 0.1 -0.1 0.7 -0.1 -0.0 0.6 -0.0 0.1 -0.0 -0.1 -0.1 0.4 -0.0 0.1 -0.2 -0.4 -0.2 -0.2 -0.4
Breastfed as a baby 0.7 0.8 1.8 0.6 1.0 1.3 0.7 -1.3 -1.4 0.1 0.8 1.2 1.0 0.7 0.9 0.9 0.6 0.7 1.3 0.8 0.8 0.7 0.6 1.0 0.8 0.5
Tense / ‘highly strung’ 0.7 1.2 2.1 -1.2 -1.0 -1.3 -1.2 1.0 0.7 -1.3 -1.2 -0.5 0.2 -1.2 -1.3 -1.2 -1.2 -0.9 -1.2 -1.1 -1.4 -1.3 -1.2 -1.4 -0.9 -0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 1.2 0.9 0.7 0.0 1.1 -0.2 -0.5 1.1 0.5 -0.4 -0.5 0.5 0.4 -0.1 0.5 0.8 -0.2 0.5 0.3 0.6 0.7 0.3 0.6 -0.0
Hair/balding pattern: Pattern 4 0.1 0.3 0.9 -0.0 -0.5 -0.7 0.6 0.9 0.7 -0.7 -0.2 -0.8 -0.8 -0.2 -0.3 -0.8 0.0 -0.6 -0.9 -0.3 0.1 -0.2 -0.1 -0.1 -0.2 -0.3
Birth weight of first child 0.1 0.1 0.6 -0.2 -0.1 0.2 -0.3 -0.4 0.3 0.2 -0.1 -0.0 0.2 -0.1 0.1 -0.3 0.2 -0.6 0.8 -0.2 0.4 -0.3 -0.3 0.1 -0.3 -0.2
Peak expiratory flow (PEF) 0.4 0.9 3.1 0.9 1.3 1.2 0.1 -0.2 -0.9 1.2 0.8 1.8 0.9 0.8 0.9 1.3 0.5 1.0 1.6 0.9 0.9 0.8 0.6 0.9 0.8 0.7
Pulse wave reflection index 0.1 0.1 1.1 0.3 0.3 0.1 -0.2 -0.3 -0.3 0.4 0.0 0.0 1.0 0.1 0.2 0.3 -0.5 0.4 0.2 0.1 -0.1 0.0 -0.0 -0.0 0.1 0.1
Ever highly irritable/argumentative for 2 days 0.2 0.2 1.9 -0.4 -0.1 -0.3 -0.6 1.4 1.0 -1.1 -0.1 0.1 0.6 -0.1 -0.0 0.1 -0.4 -0.3 0.1 -0.1 -0.3 0.0 -0.4 -0.0 0.0 -0.2
Loud music exposure frequency 0.1 0.1 0.8 -0.3 0.3 0.1 0.0 0.9 0.6 -0.7 -0.2 0.2 -0.4 -0.2 -0.1 0.1 0.2 -0.3 -0.3 -0.2 -0.2 -0.1 -0.3 -0.1 0.0 0.2
Qualifications: O levels/GCSEs or equivalent 1.4 2.2 6.9 1.5 0.9 1.5 0.4 -2.2 -1.9 2.6 1.3 1.4 -0.0 1.3 1.2 1.1 1.4 1.6 2.3 1.4 1.5 1.3 1.2 1.2 1.8 1.2
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 2.3 1.1 0.8 0.5 1.0 -0.1 -0.1 0.6 1.0 0.8 0.4 1.0 1.0 0.6 1.1 1.0 1.5 0.9 1.2 0.9 1.0 1.1 1.1 1.3
Blood clot in the leg (DVT) 2.9 3.8 6.0 -2.3 -1.6 -2.0 -1.9 2.5 2.0 -2.0 -2.0 -1.8 0.3 -2.1 -2.0 -1.6 -2.1 -2.0 -1.7 -2.1 -2.0 -2.1 -2.1 -2.1 -2.0 -1.8
Medication: Paracetamol 0.2 0.4 1.9 -0.2 -0.5 -0.5 -0.8 1.4 1.2 0.5 -0.4 -0.5 0.6 -0.4 -0.2 -0.5 -0.9 -0.7 0.1 -0.4 -0.5 -0.5 -0.9 -0.4 -0.4 -0.6
Headache pain in last month 0.2 0.3 4.1 0.3 0.0 0.7 0.1 -0.6 -0.8 2.0 0.1 0.4 0.2 0.2 0.2 -0.1 0.0 0.3 0.8 0.1 0.5 0.1 0.1 0.2 0.0 -0.2
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 1.3 0.5 0.2 0.6 0.1 -0.9 0.1 0.8 0.5 -0.3 -1.1 0.4 0.4 -0.2 0.1 -0.3 0.6 0.3 0.7 0.4 0.3 0.5 0.1 -0.4
Glaucoma (self-reported) 0.4 0.5 1.2 -0.6 -0.7 -0.8 -0.5 0.4 0.7 -0.6 -0.8 0.0 -0.0 -0.8 -0.7 -0.7 -1.0 -0.6 -0.8 -0.7 -1.1 -0.8 -0.7 -0.9 -0.9 -0.3
Gout (self-reported) 0.1 0.1 1.1 -0.1 -0.0 -0.1 0.4 1.1 0.8 0.3 -0.0 0.5 0.6 -0.1 0.1 0.2 0.4 0.1 0.0 -0.0 -0.0 -0.1 -0.1 0.2 0.0 -0.0
Hypothyroidism/myxoedema (self-reported) 1.0 1.9 3.5 -1.0 -1.0 -1.8 -1.5 -0.2 0.3 -1.2 -1.3 -1.5 -1.9 -1.4 -1.5 -1.8 -1.6 -1.4 -1.6 -1.2 -1.2 -1.3 -1.2 -1.7 -1.5 -1.0
Medication: Amlodipine 0.6 0.8 1.7 0.9 1.2 0.8 1.0 -0.4 -0.5 -0.2 1.1 1.1 0.7 1.2 1.2 1.0 0.4 0.9 0.6 1.1 0.8 1.3 0.9 1.0 0.9 0.7
Medication: Ventolin 100micrograms inhaler 0.9 1.1 2.2 -1.0 -1.0 -1.1 -1.2 1.0 0.8 0.3 -1.2 -0.2 0.6 -1.0 -0.9 -1.1 -1.3 -1.3 -0.8 -1.1 -1.3 -1.1 -1.5 -1.3 -1.3 -1.1
Birth weight 0.4 0.9 2.8 0.5 0.8 1.1 -0.0 -0.7 -1.1 1.5 0.6 1.2 1.7 0.6 0.7 1.5 0.2 1.1 1.2 0.8 0.5 0.6 0.5 0.6 1.2 1.0
Chronic bronchitis/emphysema (mother) 2.7 3.1 6.6 -1.7 -1.3 -2.0 -1.4 2.0 2.6 -0.1 -1.8 -1.8 -0.3 -1.9 -1.8 -1.3 -2.0 -1.4 -2.3 -1.9 -1.9 -1.9 -1.9 -1.8 -1.7 -1.9
High blood pressure (siblings) 0.2 0.3 1.5 0.6 0.5 0.1 1.0 -0.4 -0.4 -0.1 0.5 -1.1 -1.2 0.6 0.2 -0.1 0.4 0.4 -0.9 0.4 0.2 0.6 0.8 0.4 0.4 -0.4
Forced vital capacity (FVC), Best measure 0.1 0.3 2.9 -0.2 0.0 0.7 -0.0 -0.2 -0.1 0.3 0.0 1.7 0.3 -0.1 0.1 0.3 0.6 0.2 1.3 -0.0 0.1 -0.0 0.1 0.2 0.4 0.6
Body fat percentage 0.7 3.0 5.1 -1.7 -1.7 -1.7 -1.3 2.0 2.3 -1.2 -1.8 -1.2 -0.3 -1.7 -1.6 -2.0 -1.6 -2.2 -1.0 -1.8 -2.1 -1.7 -2.0 -1.7 -1.9 -1.9
Leg fat percentage (right) 0.2 0.8 3.1 -0.6 -0.9 -0.7 -0.4 1.6 1.7 -0.5 -0.9 -0.4 0.2 -0.7 -0.7 -0.9 -0.8 -1.1 -0.4 -0.9 -1.1 -0.7 -1.0 -0.7 -0.8 -1.2
Arm fat-free mass (right) 2.2 11.5 17.5 -3.9 -3.5 -3.4 -4.1 3.1 3.4 -0.4 -3.9 -1.4 -0.3 -3.8 -3.7 -3.2 -4.0 -3.7 -2.3 -3.7 -4.2 -3.8 -4.0 -3.9 -3.6 -2.6
Exposure to tobacco smoke outside home 0.6 0.8 2.0 0.6 1.0 1.2 0.6 0.4 -0.8 0.1 0.8 1.2 1.4 0.9 0.9 1.2 0.7 1.0 0.9 0.8 0.8 0.9 0.7 0.9 0.9 0.4
Comparative body size at age 10 0.4 1.2 2.5 -1.3 -1.0 -1.0 -1.3 0.9 0.9 -0.1 -1.4 0.0 0.2 -1.3 -1.3 -1.1 -1.0 -0.9 -1.2 -1.3 -1.6 -1.3 -1.3 -1.3 -0.9 -1.0
Number of full brothers 1.8 2.3 4.4 -1.5 -1.3 -1.3 -1.0 1.6 1.8 -1.6 -1.6 -0.7 -0.7 -1.6 -1.7 -1.4 -1.6 -1.4 -2.1 -1.6 -1.5 -1.6 -1.6 -1.7 -1.5 -1.5
Worry too long after embarrassment 1.2 2.1 4.1 -1.3 -1.2 -1.5 -2.0 0.6 0.6 -0.7 -1.5 -1.6 -1.0 -1.5 -1.6 -1.5 -1.9 -1.3 -2.0 -1.3 -1.7 -1.4 -1.6 -1.7 -1.0 -1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.5 0.8 0.8 0.4 0.9 -0.9 -1.2 1.1 0.6 -0.4 0.0 0.7 0.6 0.3 0.9 1.1 0.8 0.6 0.6 0.6 0.9 0.6 0.5 0.3
Wheeze or whistling in the chest in last year 0.4 0.7 5.0 -0.6 -0.5 -0.3 -0.9 1.1 0.2 0.2 -0.8 0.7 2.2 -0.6 -0.5 -0.1 -1.2 -0.7 -0.3 -0.6 -0.8 -0.6 -1.2 -0.9 -1.0 -0.5
Number of children fathered 1.2 1.3 3.0 -1.2 -1.1 -1.1 -1.1 0.8 1.3 0.4 -1.2 -1.0 -0.1 -1.2 -1.1 -1.2 -1.7 -1.0 -1.1 -1.2 -1.1 -1.3 -1.1 -1.3 -1.4 -1.4
Reason for reducing amount of alcohol drunk: Health precaution 2.5 2.9 4.0 -2.0 -2.0 -1.9 -1.2 1.2 2.0 0.4 -1.9 -1.9 -1.3 -1.9 -1.9 -1.9 -1.8 -1.6 -1.3 -1.9 -1.6 -1.8 -1.4 -1.8 -2.0 -1.6
Age at first live birth 5.6 10.0 16.8 3.5 3.3 3.2 3.3 -3.1 -3.1 2.1 3.6 1.6 -0.7 3.5 3.4 2.5 4.1 3.1 2.6 3.4 3.5 3.6 3.5 3.9 3.4 2.6
Pulse wave peak to peak time 0.2 0.3 2.0 -0.1 -0.5 -0.4 0.5 0.1 0.4 0.6 0.2 0.1 -0.7 0.1 0.2 0.1 1.4 -0.1 1.2 0.2 0.5 0.2 0.5 0.3 0.3 0.8
Health satisfaction 0.3 0.4 1.6 0.4 0.3 0.5 0.5 -0.8 -0.5 -0.9 0.3 -0.7 0.6 0.4 0.3 0.5 -0.0 0.6 1.1 0.5 0.3 0.3 0.4 0.1 0.8 1.3
Shortness of breath walking on level ground 1.2 1.5 4.9 -1.0 -0.9 -1.4 -0.5 2.2 1.9 -0.5 -1.0 -1.4 0.1 -1.0 -1.0 -0.9 -1.6 -1.3 -1.3 -1.1 -0.9 -1.0 -1.0 -1.1 -1.4 -1.4
Qualifications: College or University degree 0.2 0.7 3.7 1.1 0.7 0.6 0.6 0.1 0.2 1.9 0.9 1.2 1.0 0.9 0.8 1.0 0.3 0.8 -0.2 0.6 0.9 0.8 0.7 0.9 0.7 0.3
Eye problems/disorders: None of the above 0.6 0.7 3.5 0.5 0.8 0.9 0.3 -0.5 -0.7 1.1 0.6 0.5 0.6 0.6 0.7 0.9 1.1 0.9 1.9 0.8 0.9 0.6 0.7 0.7 0.8 0.9
Mouth/teeth dental problems: Loose teeth 1.5 1.8 3.9 -1.4 -2.0 -2.0 -1.4 1.9 1.5 -0.9 -1.4 -0.1 1.4 -1.4 -1.3 -0.7 -1.5 -1.4 -0.6 -1.3 -1.1 -1.5 -1.3 -1.6 -1.3 -0.0
Emphysema/chronic bronchitis 0.9 1.0 4.2 -1.0 -0.6 -1.0 -1.0 0.6 0.8 -2.1 -0.9 -0.6 -0.7 -0.9 -1.0 -0.8 -1.2 -1.0 -1.7 -0.8 -1.0 -0.9 -1.1 -1.0 -0.8 -0.5
Medication for pain relief, constipation, heartburn 0.1 0.2 1.3 0.1 0.5 0.2 -0.3 -1.2 -0.6 -0.4 0.2 0.4 -0.5 0.2 0.0 0.4 0.5 0.4 0.4 0.1 0.1 0.2 0.4 0.2 0.2 0.3
Neck or shoulder pain in last month 0.4 0.5 1.4 -0.8 -1.0 -0.2 -1.2 -0.1 -0.3 -0.6 -0.8 -0.2 0.7 -0.7 -0.8 -0.3 -0.9 -0.9 -0.8 -0.6 -0.7 -0.7 -1.2 -1.0 -0.6 -0.2
Medication: Blood pressure 0.1 0.3 2.4 -0.3 -0.2 -0.4 -0.2 1.0 0.1 -0.6 -0.3 0.5 1.5 -0.3 -0.3 0.4 -0.3 0.2 -0.6 -0.2 -0.5 -0.3 -0.3 -0.4 -0.1 0.3
Angina (self-reported) 3.4 4.4 7.3 2.0 1.7 1.9 2.1 -1.1 -2.0 1.6 2.0 2.4 2.6 2.1 2.2 2.5 2.4 2.3 1.7 2.2 1.9 2.1 1.9 2.0 2.5 2.7
Migraine (self-reported) 0.1 0.1 0.8 -0.2 -0.0 -0.0 0.1 0.3 0.4 0.9 0.0 -0.0 0.8 -0.0 -0.1 0.4 0.0 0.5 -0.6 -0.0 0.0 -0.1 0.2 0.1 -0.2 0.4
Medication: Ibuprofen 0.3 0.4 1.8 -0.1 -0.1 -0.5 0.3 -0.5 0.4 -1.0 -0.2 -0.7 -1.3 -0.3 -0.2 -0.9 -0.6 -0.7 -1.3 -0.2 0.0 -0.3 -0.1 -0.3 -0.4 -0.5
Medication: Allopurinol 0.2 0.2 1.5 -0.4 -0.3 -0.4 0.3 1.2 0.8 0.5 -0.3 0.3 1.1 -0.3 -0.3 0.3 0.6 0.3 0.3 -0.3 -0.4 -0.3 -0.2 -0.1 -0.1 -0.0
Medication: Omeprazole 0.1 0.2 0.6 -0.3 -0.8 0.0 0.5 0.3 0.1 -0.7 -0.0 0.6 0.6 0.0 0.2 0.1 0.6 -0.2 0.7 0.1 0.2 -0.1 0.0 0.1 0.3 0.5
Medication: Seretide 50 evohaler 1.7 2.0 3.8 -1.8 -1.4 -0.5 -1.5 1.7 0.4 -1.3 -1.8 0.6 0.8 -1.5 -1.4 -1.1 -0.8 -1.4 -0.9 -1.7 -1.7 -1.6 -1.9 -1.4 -1.4 -1.9
Mean time to correctly identify matches 0.7 1.3 6.2 0.9 0.8 -0.1 1.2 -2.5 -1.3 -1.5 1.0 -0.8 -1.2 1.0 1.0 -0.0 0.6 0.7 0.4 1.2 1.3 1.0 1.3 0.6 0.8 2.1
Heart disease (mother) 1.4 1.7 4.0 1.2 1.2 1.8 0.7 -1.6 -2.0 1.0 1.2 0.8 0.3 1.2 1.3 0.8 1.4 1.5 1.9 1.3 1.3 1.2 1.0 1.3 1.7 0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 4.4 -0.8 -0.3 -0.8 -0.7 0.2 0.3 -0.2 -0.5 -1.3 -0.9 -0.5 -0.7 -0.5 -0.7 -0.4 -2.1 -0.6 -0.9 -0.4 -0.5 -0.6 -0.7 -0.7
Whole body fat mass 1.8 7.5 11.0 -2.9 -2.8 -2.7 -2.6 2.9 3.1 -1.4 -3.0 -1.8 -0.7 -2.9 -2.8 -3.0 -2.8 -3.2 -1.9 -3.0 -3.3 -2.9 -3.2 -2.9 -3.0 -2.7
Leg fat mass (right) 1.3 5.0 7.6 -2.3 -2.3 -2.0 -2.3 2.4 2.6 -0.8 -2.5 -1.4 -0.6 -2.3 -2.3 -2.4 -2.4 -2.6 -1.3 -2.4 -2.8 -2.3 -2.6 -2.3 -2.3 -2.3
Arm predicted mass (right) 1.9 9.8 15.3 -3.6 -3.2 -3.1 -3.8 2.9 3.2 -0.3 -3.6 -1.1 0.1 -3.5 -3.4 -2.8 -3.9 -3.4 -2.0 -3.4 -3.9 -3.5 -3.8 -3.6 -3.4 -2.4
Pulse rate, automated reading 0.2 0.7 2.9 0.5 0.5 0.8 -0.2 -1.2 -1.0 -0.6 0.7 0.9 0.4 0.8 0.7 0.7 0.6 0.6 1.7 0.8 0.6 0.7 0.7 0.5 0.8 1.2
Alcohol intake frequency. 0.7 1.7 7.1 0.9 1.0 1.5 0.7 -2.4 -2.7 -0.3 0.9 1.2 1.9 1.0 1.0 1.4 0.6 1.1 1.0 1.2 0.4 1.1 0.6 0.6 1.2 1.9
Comparative height size at age 10 0.3 1.8 3.6 -1.9 -1.3 -1.0 -1.2 0.7 0.9 -1.3 -1.6 -0.2 0.6 -1.6 -1.5 -0.7 -1.8 -1.5 -1.2 -1.5 -1.7 -1.5 -1.8 -1.6 -1.4 -0.9
Number of full sisters 0.8 1.0 2.1 -0.9 -1.2 -1.2 -0.8 1.5 1.4 -0.4 -1.0 -0.5 0.8 -1.0 -1.0 -0.4 -1.3 -0.9 -0.8 -1.0 -1.0 -1.1 -0.8 -1.0 -1.1 -0.9
Suffer from ‘nerves’ 0.1 0.1 0.6 0.2 0.0 -0.3 0.3 -0.5 -0.6 0.7 -0.1 -0.6 -0.0 -0.0 -0.0 -0.4 0.6 0.2 -0.4 -0.1 -0.2 -0.1 0.1 0.2 -0.0 -0.2
Overall health rating 1.4 2.9 5.7 -2.0 -2.4 -1.7 -1.7 1.2 1.1 -1.2 -2.2 -1.4 0.4 -2.1 -2.0 -1.5 -1.4 -1.7 -0.4 -1.9 -2.0 -2.1 -2.1 -2.4 -1.5 -0.7
Chest pain or discomfort 0.8 1.1 3.3 0.7 0.9 1.1 0.5 -0.6 -1.1 0.9 0.8 1.5 1.8 0.9 1.0 1.2 0.9 1.1 1.4 1.0 0.8 0.9 0.7 0.7 1.1 1.3
Had major operations 0.5 0.6 3.0 -0.3 -0.7 -0.9 0.3 0.9 1.2 -0.1 -0.3 -1.5 -1.7 -0.3 -0.5 -0.4 -0.4 -0.6 -1.3 -0.4 -0.5 -0.2 -0.2 -0.2 -0.8 -0.6
Age at last live birth 6.0 8.7 15.9 3.0 3.0 3.0 2.9 -2.5 -3.0 2.3 3.2 1.6 0.0 3.2 3.1 2.4 4.0 3.1 3.2 3.1 3.3 3.2 3.1 3.5 3.3 2.6
Family relationship satisfaction 0.4 0.5 1.3 0.6 0.4 0.7 0.3 -0.8 -1.0 -0.2 0.6 -0.2 -0.0 0.7 0.5 0.8 0.4 0.9 0.6 0.8 0.8 0.6 0.8 0.6 0.9 1.1
Leg pain on walking 0.5 0.6 1.3 -1.1 -1.1 -0.7 -0.8 0.7 0.5 0.1 -1.0 -0.2 0.9 -1.0 -1.0 0.0 -0.7 -0.5 0.2 -0.8 -1.1 -0.9 -1.0 -1.0 -0.5 0.4
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.2 1.3 0.2 0.1 0.3 0.1 0.8 0.3 0.8 0.0 -0.1 0.4 0.1 0.1 0.3 0.8 0.3 1.1 -0.0 0.2 0.0 0.1 0.3 0.3 -0.3
Commuting to job workplace: Car/motor vehicle 0.5 0.5 1.5 -0.8 -0.5 -0.6 -0.5 1.2 1.1 -1.2 -0.9 0.2 0.8 -0.7 -0.6 -0.6 -0.2 -0.6 0.2 -0.8 -0.7 -0.6 -0.9 -0.5 -0.8 -0.4
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 2.0 -0.3 -0.1 -0.5 -0.4 0.6 0.3 -1.4 -0.0 -0.2 0.1 0.0 0.0 -0.2 -0.5 -0.5 -0.9 -0.2 0.1 -0.2 -0.2 -0.1 -0.6 -0.3
Medication: Aspirin 0.4 0.5 2.6 0.2 0.0 0.2 0.7 0.4 -0.7 0.5 0.4 1.2 1.6 0.5 0.4 0.8 0.3 0.7 -0.1 0.7 0.2 0.5 0.6 0.1 0.6 1.4
Supplements: Vitamin C 1.3 1.6 3.6 1.1 1.0 1.5 0.7 -1.8 -1.6 0.5 1.1 1.9 0.5 1.0 1.1 1.2 1.2 1.3 1.0 1.3 1.1 1.2 0.9 1.1 1.6 1.7
Knee pain experienced in last month 0.2 0.2 1.5 -0.4 -0.5 -0.4 -0.3 -0.2 -0.2 0.1 -0.3 -0.1 1.2 -0.2 -0.2 0.3 0.2 0.2 1.2 -0.1 -0.4 -0.2 -0.0 -0.5 0.3 0.8
Hypertension (Self-reported) 0.7 1.8 3.3 -1.5 -1.3 -1.4 -1.1 1.5 1.1 -1.2 -1.5 -1.3 0.3 -1.4 -1.5 -1.0 -1.7 -1.0 -1.8 -1.4 -1.8 -1.4 -1.4 -1.5 -1.2 -0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.3 1.6 -0.3 -0.4 -0.2 0.2 1.0 0.6 0.6 -0.4 0.6 1.3 -0.3 -0.1 0.1 -0.2 -0.4 -0.1 -0.5 -0.4 -0.4 -0.6 -0.2 -0.6 -0.5
Illnesses of father: Heart disease 1.8 2.5 4.6 1.6 1.8 1.6 1.2 -1.6 -1.7 1.1 1.5 1.4 2.1 1.4 1.7 1.8 1.4 1.7 1.6 1.6 1.2 1.5 1.3 1.3 1.8 1.7
Illnesses of siblings: Diabetes 0.8 1.0 2.2 -1.1 -1.5 -0.9 -0.6 1.1 1.3 1.0 -1.2 0.0 0.5 -1.1 -1.0 -0.9 -0.4 -0.9 -0.3 -1.2 -1.4 -1.3 -1.0 -1.1 -1.1 -0.7
Smoking status: Previous 0.2 0.2 0.8 -0.2 0.0 -0.1 -0.8 -0.5 -0.1 -0.9 -0.3 0.3 0.5 -0.3 -0.1 -0.3 -0.8 -0.9 -0.1 -0.3 -0.1 -0.3 -0.7 -0.4 -0.6 -0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.3 1.7 -0.6 -0.5 0.0 0.0 1.3 0.7 0.3 -0.6 1.1 1.0 -0.5 -0.5 0.2 0.6 -0.1 0.9 -0.4 -0.2 -0.4 -0.4 -0.3 -0.1 -0.4
Whole body fat-free mass 2.2 12.7 19.6 -4.1 -3.5 -3.6 -4.2 3.0 3.3 -0.3 -4.1 -1.9 -0.7 -4.0 -3.9 -3.5 -4.2 -3.8 -2.7 -4.0 -4.4 -4.0 -4.2 -4.1 -3.8 -2.9
Leg fat-free mass (right) 2.5 13.1 19.0 -4.2 -3.5 -3.7 -4.2 2.7 3.0 -0.9 -4.1 -2.2 -1.2 -4.0 -3.9 -3.9 -4.3 -4.0 -2.9 -4.0 -4.4 -4.0 -4.2 -4.1 -4.0 -3.0
Arm fat percentage (left) 1.0 3.8 5.8 -2.0 -1.9 -1.9 -1.8 1.9 2.2 -1.0 -2.2 -1.5 -0.6 -2.0 -1.9 -2.4 -2.0 -2.4 -1.1 -2.1 -2.4 -2.0 -2.3 -2.0 -2.2 -2.1
Average weekly red wine intake 2.5 3.7 6.3 -2.5 -2.0 -1.8 -2.2 1.3 1.9 -0.5 -2.4 -0.6 -0.2 -2.4 -2.4 -1.3 -1.9 -1.6 -1.5 -2.2 -2.5 -2.1 -2.2 -2.4 -1.8 -1.8
Handedness (chirality/laterality): Left-handed 0.4 0.4 1.0 -0.7 -0.4 -0.9 -0.7 0.9 0.2 1.0 -0.6 -0.9 0.1 -0.7 -0.7 -0.5 -0.4 -0.2 -1.0 -0.6 -0.7 -0.6 -0.7 -0.7 -0.5 -0.4
Mood swings 0.9 1.6 5.2 1.1 1.2 1.3 1.3 -0.3 -1.5 0.5 1.0 1.2 2.3 1.0 1.2 1.7 1.0 1.2 1.7 1.1 1.0 0.9 0.8 1.1 1.3 1.5
Loneliness, isolation 0.2 0.2 1.3 0.4 0.6 0.4 0.6 0.3 -1.1 -0.2 0.4 -0.4 0.3 0.3 0.4 0.1 0.5 0.5 0.4 0.5 0.2 0.2 0.4 0.4 0.7 0.9
Long-standing illness, disability or infirmity 0.5 0.8 2.7 0.6 0.8 1.0 0.7 0.0 -0.9 0.8 0.5 0.7 1.6 0.7 0.7 1.2 1.2 1.1 1.5 0.6 0.5 0.7 0.4 0.6 0.8 0.8
Ever had bowel cancer screening 1.3 1.6 3.8 1.2 1.3 1.0 1.4 -1.9 -1.4 0.5 1.5 0.2 -0.4 1.4 1.4 1.0 1.1 1.2 0.8 1.4 1.3 1.4 1.7 1.4 1.2 1.0
Diabetes diagnosed by doctor 0.0 0.1 0.4 0.2 0.2 0.1 -0.1 -0.3 -0.5 0.2 0.2 0.4 0.5 0.2 0.1 0.6 0.0 0.0 -0.5 0.2 -0.2 0.2 -0.2 -0.0 0.0 0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.7 7.1 -0.2 -0.5 0.5 0.2 0.0 -0.3 2.7 -0.2 0.2 1.8 -0.1 -0.0 1.0 0.7 1.1 1.3 0.0 0.3 -0.2 0.0 0.0 0.7 0.0
Friendships satisfaction 0.1 0.1 0.6 0.1 0.3 -0.1 0.4 0.3 0.3 0.2 -0.0 -0.2 0.5 -0.0 -0.1 0.6 0.2 0.8 -0.1 0.1 -0.1 0.0 0.2 0.0 0.5 0.5
Qualifications: nursing, teaching 0.2 0.4 1.1 0.6 0.4 1.0 -0.1 -0.8 -0.7 0.6 0.6 0.7 -1.1 0.5 0.4 0.4 0.1 0.4 -0.1 0.6 0.4 0.7 0.4 0.6 0.8 0.5
Commuting to job workplace: Walk 1.0 1.0 4.3 1.1 0.9 1.0 0.5 -1.8 -1.3 2.1 1.0 -0.3 -1.3 0.9 0.8 0.3 0.6 0.8 -0.3 1.0 1.0 0.8 1.0 0.7 0.9 0.8
Eye problems/disorders: Cataract 0.6 0.6 2.1 -0.6 -0.7 -0.8 -0.5 0.4 0.9 -1.1 -0.6 -0.8 -0.6 -0.7 -0.7 -0.8 -1.3 -0.8 -1.4 -0.6 -0.7 -0.6 -0.7 -0.7 -0.5 -0.9
Mouth/teeth dental problems: Mouth ulcers 1.9 3.0 7.5 1.9 1.9 1.1 1.1 -1.8 -1.6 -0.5 1.8 2.7 0.8 1.9 1.7 1.5 1.8 1.6 1.4 1.9 1.9 1.8 1.7 1.6 1.8 2.1
Medication for cholesterol 0.9 1.3 2.5 1.4 1.2 1.0 1.3 -0.2 -0.4 0.3 1.4 1.6 0.3 1.3 1.2 1.3 1.2 1.0 1.0 1.3 1.5 1.4 1.3 1.4 1.2 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 1.3 0.0 -0.2 -0.1 -0.1 -0.5 -0.9 0.1 -0.3 -0.6 -1.1 -0.3 -0.3 -0.8 0.6 -0.0 0.4 -0.4 -0.2 -0.3 -0.0 0.0 -0.2 -0.9
Back pain experienced in last month 0.2 0.3 0.9 -0.6 -0.7 -0.6 -0.3 0.5 0.5 0.5 -0.7 -0.7 0.3 -0.6 -0.6 0.1 -0.0 -0.1 -0.1 -0.5 -0.9 -0.5 -0.6 -0.6 -0.1 -0.3
Mineral and other dietary supplements 1.9 2.6 4.2 -1.7 -1.8 -1.8 -1.5 1.7 1.8 -0.7 -1.9 -0.9 0.5 -1.8 -1.7 -1.3 -1.5 -1.6 -1.2 -1.8 -2.1 -1.7 -1.9 -1.9 -1.9 -1.3
Breast cancer (self-reported) 0.4 0.5 2.6 -0.4 -0.4 -0.5 0.1 1.3 1.6 -0.2 -0.6 -0.7 -0.1 -0.5 -0.6 -0.4 -0.4 -0.6 -1.1 -0.7 -0.7 -0.6 -0.6 -0.3 -0.6 -1.2
Asthma (self-reported) 0.4 0.8 2.2 -1.0 -0.9 -0.8 -1.5 0.1 0.1 0.5 -0.9 -0.2 0.2 -0.9 -0.8 -0.9 -1.5 -1.0 -0.7 -0.8 -1.0 -0.9 -1.3 -1.1 -1.1 -1.1
Osteoporosis (self-reported) 0.1 0.1 0.6 -0.3 0.1 -0.3 0.1 0.1 0.5 -0.8 -0.5 0.1 0.6 -0.3 -0.3 -0.0 0.3 0.1 0.3 -0.4 -0.4 -0.2 -0.4 -0.3 -0.1 0.0
Osteoarthritis (self-reported) 2.0 2.7 4.3 -2.1 -2.1 -1.5 -1.7 1.8 1.7 -0.4 -1.9 -1.2 -0.0 -1.8 -1.8 -1.5 -1.6 -1.7 -1.1 -1.7 -2.0 -1.7 -2.0 -1.9 -1.5 -1.3
Medication: Aspirin 0.4 0.5 2.5 0.3 0.1 0.2 0.8 0.2 -0.8 0.6 0.5 1.2 1.5 0.5 0.5 0.8 0.5 0.9 0.2 0.8 0.2 0.6 0.7 0.1 0.7 1.6
Medication: Gliclazide 0.4 0.4 1.9 0.6 0.9 0.7 0.4 -0.4 -0.4 1.4 0.6 0.8 0.7 0.6 0.6 0.8 0.5 0.8 0.1 0.7 0.3 0.7 0.5 0.5 0.7 0.5
Illnesses of father: None of the above (group 1) 0.7 0.9 2.2 -1.4 -1.5 -0.9 -1.0 0.8 0.9 0.2 -1.1 -0.4 0.0 -1.1 -1.0 -0.8 -0.8 -1.2 0.1 -1.0 -0.8 -1.2 -1.1 -1.0 -1.1 -0.7
Smoking status: Current 0.1 0.2 0.8 0.1 -0.0 0.3 0.8 0.3 0.0 0.1 0.2 0.0 0.6 0.1 0.2 0.5 0.9 0.7 0.1 0.2 -0.1 0.2 0.6 0.2 0.3 0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.1 2.3 5.7 1.5 1.0 1.6 1.6 -0.9 -0.7 1.2 1.4 1.6 1.3 1.4 1.4 1.7 2.0 1.4 2.4 1.3 1.9 1.3 1.6 1.6 1.6 1.7
Whole body water mass 2.1 12.3 19.0 -4.0 -3.5 -3.5 -4.1 3.0 3.3 -0.2 -4.0 -1.8 -0.7 -3.9 -3.8 -3.4 -4.2 -3.7 -2.6 -3.9 -4.4 -3.9 -4.1 -4.0 -3.8 -2.9
Leg predicted mass (right) 2.5 13.2 19.1 -4.2 -3.5 -3.7 -4.3 2.7 3.0 -0.9 -4.1 -2.3 -1.3 -4.0 -3.9 -3.9 -4.3 -4.0 -2.9 -4.0 -4.4 -4.1 -4.2 -4.2 -4.0 -3.0
Arm fat mass (left) 1.9 7.8 12.0 -3.0 -2.9 -2.8 -2.8 2.5 2.9 -1.6 -3.1 -1.9 -0.9 -3.0 -2.9 -3.1 -2.9 -3.3 -1.8 -3.1 -3.5 -3.0 -3.3 -3.0 -3.1 -2.6
Number of self-reported non-cancer illnesses 0.5 0.9 2.3 -1.2 -0.9 -1.2 -0.8 0.9 0.2 -0.2 -1.2 -0.2 0.5 -1.0 -1.1 -1.0 -0.9 -0.7 -1.1 -1.0 -1.5 -1.1 -1.1 -1.3 -0.8 -0.2
Average weekly champagne plus white wine intake 0.2 0.2 1.5 -0.2 -0.2 -0.4 -0.5 -0.7 -0.3 0.1 -0.2 -0.4 -1.2 -0.2 -0.3 -0.5 -0.8 -0.2 -0.9 -0.2 -0.3 -0.1 -0.0 -0.4 -0.4 -0.4
Miserableness 1.9 3.3 6.9 1.9 1.6 2.1 1.1 -1.5 -2.6 1.3 1.5 2.1 2.5 1.6 1.7 2.1 1.1 1.7 2.5 1.8 1.5 1.7 1.2 1.4 2.0 1.9
Guilty feelings 0.7 1.0 5.0 1.1 1.2 0.7 0.5 -1.6 -2.2 -0.1 1.0 0.1 0.1 1.0 0.8 0.8 0.3 1.1 -0.6 1.1 1.0 0.9 0.9 0.7 1.1 1.4
Wears glasses or contact lenses 0.2 0.2 0.6 0.3 0.8 0.1 -0.2 -0.7 -0.7 0.6 0.5 0.3 0.7 0.5 0.5 0.6 -0.7 0.5 -0.4 0.5 0.0 0.5 0.3 0.1 0.3 0.3
Ever taken oral contraceptive pill 1.4 1.5 3.3 1.3 1.2 1.1 1.1 -1.1 -1.2 -1.2 1.1 1.8 1.0 1.1 1.1 1.5 1.2 1.2 1.4 1.1 0.9 1.1 1.3 1.1 1.3 1.6
Hearing aid user 0.4 0.5 2.5 0.8 0.5 0.8 0.0 -1.5 -1.6 -0.2 0.6 0.5 0.0 0.6 0.6 0.5 0.3 0.5 0.9 0.7 0.6 0.5 0.5 0.5 0.6 0.8
Mother’s age at death 0.1 0.1 0.7 -0.2 -0.1 -0.3 -0.2 -0.1 0.4 -0.8 -0.2 0.2 -0.8 -0.2 -0.2 -0.3 -0.3 -0.6 -0.2 -0.3 0.1 -0.1 -0.0 -0.1 -0.5 -0.8
Financial situation satisfaction 0.2 0.3 3.3 -0.2 -0.1 -0.0 -0.0 1.2 0.6 -1.8 -0.2 -0.2 0.8 -0.2 -0.1 0.1 0.2 0.0 0.5 -0.2 -0.1 -0.4 -0.2 0.1 0.1 0.4
Tinnitus: Yes, now most or all of the time 0.0 0.1 0.4 -0.0 0.2 0.1 0.4 0.2 0.1 -0.7 -0.2 0.3 0.2 -0.2 -0.1 -0.2 -0.0 0.0 0.1 -0.1 -0.3 -0.2 -0.1 -0.0 -0.0 0.4
Commuting to job workplace: Public transport 1.1 1.3 3.1 1.3 1.2 1.3 0.9 -0.9 -0.9 1.1 1.2 1.8 1.4 1.1 1.2 1.7 0.8 1.1 0.3 1.2 1.1 1.1 0.8 1.1 1.2 0.9
Eye problems/disorders: Glaucoma 2.5 3.0 4.6 -1.8 -1.9 -2.1 -1.4 1.2 2.0 0.6 -1.8 -2.0 -0.6 -1.9 -1.9 -1.5 -1.9 -1.4 -1.7 -1.9 -2.1 -1.8 -1.6 -2.0 -1.9 -1.6
Medication: Blood pressure 0.4 0.7 3.0 -0.6 -0.7 -0.7 -0.2 0.8 0.8 -0.3 -0.7 -1.7 -0.1 -0.7 -0.7 -0.7 -1.0 -0.6 -1.7 -0.7 -0.9 -0.7 -0.6 -0.7 -0.7 -0.5
Pain type(s) experienced in last month: Hip pain 0.2 0.3 2.4 -0.4 -0.4 -0.7 -0.6 0.2 0.1 -1.6 -0.4 0.4 0.0 -0.3 -0.3 -0.3 0.0 -0.7 -0.5 -0.3 -0.9 -0.1 -0.5 -0.4 -0.5 0.0
Supplements: Fish oil (including cod liver oil) 0.8 1.0 2.3 1.1 1.1 0.9 1.2 -0.5 -0.5 1.3 1.2 0.3 -0.6 1.2 1.1 0.8 1.1 0.9 0.8 1.0 1.5 1.0 1.4 1.4 0.9 0.4
High cholesterol (Self-reported) 0.3 0.5 2.1 0.5 0.6 0.9 0.9 -1.0 -1.4 -0.8 0.5 -0.5 0.1 0.5 0.4 0.8 0.7 1.0 0.3 0.6 0.2 0.6 0.7 0.5 0.8 1.0
Medication: Bendroflumethiazide 0.8 1.3 2.5 -0.9 -0.9 -1.3 -1.0 1.4 1.3 0.4 -1.2 -1.1 0.3 -1.1 -1.0 -0.9 -1.3 -1.0 -0.8 -1.2 -1.4 -1.2 -1.3 -1.1 -1.4 -1.6
Medication: Paracetamol 0.7 1.0 2.0 -0.8 -1.0 -1.3 -1.0 1.2 1.4 0.6 -1.0 -1.0 0.3 -1.0 -0.9 -1.0 -1.2 -1.0 -0.9 -0.9 -1.1 -1.0 -1.2 -1.1 -1.0 -0.9
Medication: Lisinopril 0.3 0.4 1.1 0.6 0.6 0.3 1.0 -0.5 -0.7 -0.3 0.5 0.1 1.0 0.5 0.5 0.9 0.3 1.0 -0.4 0.6 0.7 0.6 0.5 0.4 0.5 0.8
Medication: Atorvastatin 0.1 0.2 1.0 0.1 -0.0 0.2 0.3 -0.6 -0.6 0.0 -0.1 0.7 0.4 0.0 0.0 0.4 1.0 0.3 0.8 0.0 -0.1 -0.1 0.1 0.2 0.3 0.5
Illnesses of father: High blood pressure 0.1 0.1 1.3 0.4 0.3 0.4 0.0 -0.2 0.0 1.1 -0.0 0.6 0.3 0.0 -0.1 0.3 0.2 0.4 0.1 0.0 -0.4 0.2 -0.0 0.1 0.3 -0.2
Alcohol drinker status: Never 0.2 0.2 0.6 -0.6 -0.3 -0.2 -0.1 -0.4 -0.8 -0.2 -0.5 0.4 0.8 -0.5 -0.5 0.1 -0.4 -0.0 -0.7 -0.3 -0.6 -0.4 -0.4 -0.7 -0.3 0.1
Ever smoked 0.2 0.4 3.4 -0.1 -0.3 -0.2 -0.5 0.9 0.9 0.0 -0.4 0.7 1.8 -0.4 -0.1 0.2 -0.1 -0.5 0.5 -0.5 -0.4 -0.4 -0.6 -0.3 -0.4 -0.5
Basal metabolic rate 2.3 12.9 19.6 -4.1 -3.5 -3.6 -4.1 3.1 3.4 -0.6 -4.1 -2.0 -0.9 -4.0 -3.9 -3.6 -4.2 -3.9 -2.6 -4.0 -4.4 -4.0 -4.2 -4.1 -3.9 -3.0
Leg fat percentage (left) 0.4 1.5 3.4 -1.1 -1.2 -1.0 -0.8 1.6 1.8 -1.0 -1.3 -0.9 -0.4 -1.1 -1.1 -1.5 -1.2 -1.5 -0.8 -1.2 -1.5 -1.1 -1.4 -1.1 -1.1 -1.4
Arm fat-free mass (left) 2.0 10.2 16.0 -3.7 -3.3 -3.2 -3.6 3.0 3.3 -0.8 -3.6 -1.6 -0.3 -3.6 -3.5 -3.0 -3.8 -3.5 -2.1 -3.5 -4.0 -3.6 -3.8 -3.6 -3.4 -2.5
Number of operations (self-reported) 0.1 0.1 1.1 -0.2 -0.3 -0.3 0.1 -0.0 -0.5 1.1 -0.0 -0.1 0.4 0.0 -0.0 0.1 -0.1 0.3 -0.3 0.1 -0.3 0.0 0.0 -0.1 0.1 -0.1
Average weekly beer plus cider intake 0.2 0.2 2.0 -0.1 -0.3 0.2 -0.3 1.4 0.7 -0.7 -0.0 0.7 0.1 -0.0 0.1 -0.3 0.1 -0.7 0.5 -0.1 -0.1 0.0 -0.3 0.2 -0.3 -0.6
Irritability 1.2 2.1 3.7 1.9 1.7 1.6 1.8 -1.1 -0.9 -0.2 1.6 1.2 0.0 1.6 1.5 1.5 1.7 1.3 1.1 1.4 1.3 1.6 1.6 1.7 1.6 1.5
Risk taking 0.1 0.1 0.7 0.2 0.1 0.1 0.8 0.7 0.3 0.8 0.4 0.6 0.1 0.3 0.3 0.1 -0.4 0.2 -0.2 0.4 0.1 0.4 0.3 0.1 0.0 -0.1
Ever had prostate specific antigen (PSA) test 1.0 1.2 3.6 0.9 1.1 0.8 1.4 -1.9 -1.5 1.9 1.0 -0.5 -0.5 0.9 0.8 0.7 0.7 1.4 0.0 1.1 0.9 1.0 1.4 0.8 1.1 1.0
Fractured/broken bones in last 5 years 0.2 0.3 1.3 0.5 0.5 1.0 0.2 -0.1 -0.8 1.0 0.4 0.5 1.1 0.5 0.5 0.5 -0.5 0.3 0.5 0.4 0.7 0.4 0.2 0.3 0.1 0.4
Age started oral contraceptive pill 0.4 0.5 4.0 0.3 0.5 -0.3 0.5 -0.8 -0.5 -2.0 0.5 -0.7 -1.1 0.5 0.3 -0.4 -0.4 -0.4 -1.4 0.3 -0.0 0.4 0.4 0.2 -0.0 -0.1
Diastolic blood pressure, automated reading 0.7 2.2 3.8 -1.5 -1.2 -1.3 -1.7 1.6 1.5 -0.6 -1.7 -1.0 -0.8 -1.5 -1.6 -1.8 -1.9 -1.6 -1.1 -1.6 -1.4 -1.6 -1.6 -1.6 -1.6 -1.6
Ever depressed for a whole week 0.1 0.2 0.8 0.1 0.2 0.7 -0.3 0.7 -0.0 -0.4 0.3 0.9 0.9 0.3 0.4 0.2 -0.2 -0.0 0.7 0.2 0.1 0.4 -0.2 0.3 0.3 -0.3
Unable to work because of sickness or disability 0.2 0.3 1.2 -0.2 -0.8 -0.3 -0.8 0.8 0.1 0.4 -0.5 -0.3 0.5 -0.5 -0.4 -0.6 -0.4 -0.4 1.1 -0.5 -0.3 -0.4 -0.5 -0.5 -0.4 -0.6
Commuting to job workplace: Cycle 0.6 0.7 6.3 0.7 0.5 0.1 0.8 -0.7 -0.4 -1.5 0.8 -1.1 -2.5 0.6 0.3 -0.1 0.1 0.5 -0.6 0.6 0.8 0.7 1.0 0.6 0.5 0.5
Myopia 0.4 0.5 2.8 0.3 0.6 0.1 0.6 -1.7 -1.3 -1.3 0.3 0.6 -0.9 0.3 0.3 -0.1 0.9 0.1 0.2 0.4 0.4 0.3 0.6 0.2 0.5 1.2
Vascular/heart problems diagnosed by doctor 0.4 1.0 3.1 1.1 0.9 1.0 0.4 -1.2 -0.6 0.7 1.1 1.1 -0.8 1.0 1.1 0.7 1.0 0.4 1.8 1.0 1.6 1.1 1.0 1.2 0.7 0.3
Cholesterol lowering medication 0.9 1.3 4.0 1.1 1.4 1.3 0.9 -1.8 -2.0 0.8 1.1 0.1 0.8 1.1 1.2 0.9 0.7 1.2 0.7 1.2 1.1 0.9 1.0 1.0 1.1 1.4
Medication: Omeprazole (e.g. Zanprol) 0.6 0.8 3.1 -1.1 -1.6 -0.8 0.1 1.7 1.2 -0.3 -1.0 -0.4 0.6 -1.0 -0.8 -0.7 0.1 -0.8 -0.1 -1.0 -0.7 -1.0 -0.9 -0.7 -0.6 -0.7
Pain experienced in last month 0.1 0.2 0.9 0.5 0.9 0.2 -0.0 0.2 0.4 -0.2 0.5 0.7 -0.7 0.3 0.4 -0.1 -0.3 -0.2 -0.8 0.1 0.3 0.3 0.1 0.5 -0.1 -0.9
Supplements: Calcium 0.4 0.5 1.1 0.8 0.6 1.0 0.4 -0.6 -0.8 0.5 0.6 0.9 0.5 0.6 0.6 0.6 0.4 0.7 1.0 0.7 0.9 0.6 0.5 0.8 0.7 -0.1
Basal cell carcinoma (self-reported) 2.9 3.4 6.5 -2.1 -2.2 -1.2 -2.2 1.5 1.1 1.2 -2.4 -0.3 0.8 -2.3 -2.2 -1.1 -1.4 -1.7 -0.7 -2.3 -2.1 -2.4 -2.5 -2.3 -2.0 -1.7
Heart attack/myocardial infarction (self-reported) 0.6 0.8 2.1 0.7 0.7 0.7 1.0 -0.3 -1.5 -0.4 0.9 0.7 0.5 0.8 0.8 1.1 0.7 1.2 0.2 1.1 0.8 0.8 1.0 0.7 1.2 1.4
Deep venous thrombosis (DVT) (self-reported) 3.3 4.2 6.6 -2.4 -1.8 -2.1 -2.0 2.6 2.2 -1.9 -2.1 -1.9 0.4 -2.2 -2.1 -1.7 -2.3 -2.1 -1.9 -2.1 -2.1 -2.2 -2.2 -2.2 -2.1 -1.8
Heart disease (siblings) 3.1 3.8 8.2 1.9 1.4 2.0 1.6 -1.3 -2.0 1.6 1.6 1.9 2.9 1.6 1.8 2.2 2.0 2.1 2.9 1.8 1.6 1.5 1.6 1.5 2.1 2.6
Alcohol drinker status: Previous 0.3 0.4 0.9 -0.8 -1.0 -0.2 -0.4 -0.2 -0.1 -0.6 -0.7 -0.8 -0.2 -0.7 -0.6 -0.7 -0.2 -0.8 -0.0 -0.7 -0.7 -0.7 -0.9 -0.5 -0.6 -0.9
Pack years of smoking 1.2 1.7 2.9 1.3 1.4 1.7 1.2 -0.3 -0.9 -1.1 1.4 1.6 1.6 1.4 1.6 1.6 1.5 0.9 1.4 1.3 1.3 1.4 1.0 1.6 1.2 1.0
Impedance of whole body 0.7 3.8 8.8 2.3 1.7 2.0 3.0 -0.8 -1.2 -0.4 2.2 1.4 0.9 2.1 2.2 2.1 2.6 1.9 1.5 2.0 2.6 2.2 2.2 2.4 2.0 0.8
Leg fat mass (left) 1.4 5.5 8.5 -2.5 -2.4 -2.2 -2.4 2.4 2.6 -1.1 -2.6 -1.6 -0.9 -2.5 -2.4 -2.7 -2.6 -2.8 -1.5 -2.5 -2.9 -2.4 -2.8 -2.5 -2.4 -2.3
Arm predicted mass (left) 1.9 9.8 15.7 -3.6 -3.2 -3.2 -3.4 3.0 3.3 -0.7 -3.6 -1.6 -0.6 -3.5 -3.4 -3.0 -3.6 -3.4 -2.1 -3.5 -4.0 -3.5 -3.6 -3.5 -3.3 -2.5