Hub : Genes

SPECC1L

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0570	0.0240	1.6e-03	0.025	0.023	0.041	NA	0.049	4.1e-04	7.3e-04	8.3e-06	NA	1.2e-06
2	METSIM	Adipose	0.0684	0.0321	1.8e-03	0.079	0.024	0.072	0.082	0.076	7.2e-12	1.2e-04	6.4e-11	2.8e-12	1.9e-11
3	ROSMAP	Brain Pre-frontal Cortex	0.0750	0.0233	7.1e-06	0.039	0.042	0.038	0.051	0.039	7.2e-06	3.8e-06	9.1e-06	3.6e-07	8.0e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	2.6	4.2	6.6	0.3	-2.6	2.4
Bipolar Disorder or Schizophrenia	1.0	2.5	5.3	-0.4	-2.3	1.4
Depressed Affect (Nagel 2018)	0.9	1.8	4.3	-2.1	0.4	-1.0
Depression (Nagel 2018)	0.8	1.3	2.3	-1.5	1.1	-0.6
Intelligence (Savage-Jansen 2018)	0.3	0.8	2.0	-1.4	-0.1	-0.7
Neuroticism (Nagel 2018)	0.9	2.1	2.4	-1.4	1.5	-1.4
Schizophrenia (2018)	0.3	0.6	1.1	-0.8	-1.1	-0.2
Schizophrenia vs Biploar Disorder	0.6	0.8	1.3	1.0	0.3	-1.1
Worry (Nagel 2018)	1.1	2.3	3.1	-1.3	1.4	-1.8
Alzheimer’s Disease (in mother)	0.1	0.1	0.3	0.2	0.4	0.5
Alzheimer’s Disease (in father)	3.7	4.0	7.6	-2.7	0.8	-2.0
Alzheimer’s Disease (including proxy)	0.6	0.9	1.8	-1.3	0.9	-0.5
Crohns Disease (2017)	0.7	1.6	4.6	0.0	-2.1	-0.3
Irritable Bowel Disease (IBD)	0.6	1.5	1.8	1.3	-1.4	1.0
Ulcerative Colitis (UC)	1.1	2.0	4.2	2.1	-0.4	1.3
Major Depression (MDD)	0.1	0.2	0.3	-0.3	0.6	0.3
Reaction Time	1.5	2.8	8.1	-0.2	0.6	-2.8
Verbal and Numeric Reasoning (VNR)	0.2	0.5	0.7	-0.8	-0.2	-0.8
Breast Cancer	0.4	0.9	1.6	1.3	-1.0	-0.1
Ovarian Cancer	0.7	1.0	2.6	-1.6	-0.2	0.5
Prostate Cancer	1.1	1.5	3.9	-0.7	0.4	2.0
Age at First Birth	2.3	3.3	6.7	1.6	2.6	-0.9
Bipolar Disorder (2011)	1.5	1.5	2.7	1.1	-0.6	1.6
Body Mass Index (BMI) (2010)	0.5	0.6	1.3	1.2	-0.6	0.4
Coronary Artery Disease (CAD)	1.0	1.2	2.4	0.5	1.0	-1.5
Crohns Disease (2012)	0.2	0.3	0.5	0.6	-0.7	0.1
Mean Putamen Volume	2.2	2.5	4.4	-2.1	-1.3	1.2
Fasting Glucose	1.5	1.8	3.8	-2.0	0.4	-1.2
HbA1C	1.1	1.2	1.8	-0.7	-1.4	-1.2
HDL Cholesterol	0.1	0.1	0.2	-0.4	-0.4	0.0
LDL Cholesterol	1.3	2.1	3.3	-1.8	1.6	-0.5
Lupus	0.7	1.1	3.0	-0.3	-1.7	0.5
Neuroticism (2016)	0.8	1.1	2.0	1.0	1.4	0.6
Primary Biliary Cirrhosis	1.7	2.4	3.2	-1.8	0.9	-1.7
Rheumatoid Arthritis	0.9	1.3	1.9	1.0	1.0	-1.4
Schizophrenia (2014)	0.3	0.6	1.1	-0.8	-0.0	1.1
Triglycerides	0.1	0.2	0.3	0.6	0.4	-0.0
Type 2 Diabetes (T2D) (2012)	1.2	1.4	3.2	0.7	-1.8	-0.8
Ulcerative Colitis	2.7	4.0	8.1	2.8	0.6	1.9
Blood Eosinophil Count	1.4	11.0	29.6	-1.2	5.4	1.4
Blood Platelet Count	0.4	4.8	7.7	-2.8	0.5	2.5
Blood Red Count	0.2	2.1	3.3	-0.8	-1.5	1.8
Blood White Count	4.0	29.7	49.0	2.4	5.8	7.0
Heel T-Score	0.7	5.6	9.2	1.0	-3.0	2.6
BMI	0.1	0.7	1.9	1.4	-0.2	-0.1
Height	0.1	1.8	5.3	-0.4	2.3	0.2
Waist Hip Ratio (WHR)	0.5	2.2	5.0	-1.3	-0.1	-2.2
Systolic Blood Pressure	0.4	2.1	3.1	1.7	-0.7	1.8
Smoking Status	0.2	0.4	0.9	-0.1	-0.9	-0.5
Allergy or Eczema	1.6	4.3	12.3	3.5	0.7	-0.1
Cardiovascular Disease	0.1	0.3	0.7	0.8	0.4	0.2
Hypothyroidism (self reported)	0.2	0.4	0.8	-0.9	0.7	0.1
Respiratory disease	1.1	2.5	4.7	-2.2	1.1	1.3
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.5	-0.2	0.4	1.6
Lung FEV1/FVC ratio	0.1	0.6	1.3	-0.6	0.2	1.1
Lung FVC	0.5	2.6	4.2	-0.0	-1.9	-2.0
Neuroticism	0.8	2.0	2.7	-1.6	1.5	-1.0
Chronotype (morning person)	1.0	2.3	5.6	-0.3	2.4	-1.1
Hair Pigment	0.2	5.1	11.5	1.9	3.4	0.3
Tanning	0.1	0.7	1.1	-0.4	-1.0	1.0
Hand grip strength (left)	0.9	2.4	2.5	1.6	-1.5	1.5
Number of treatments/medications taken	0.1	0.1	0.4	-0.0	0.6	-0.0
Average weekly spirits intake	0.8	1.0	2.5	-0.5	-0.4	-1.6
Sensitivity / hurt feelings	1.6	2.8	7.2	1.0	2.7	-0.5
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.2	-0.6	1.5	-0.7
Hearing difficulty/problems: Yes	0.2	0.3	0.8	-0.3	0.9	-0.3
Relative age of first facial hair	2.7	5.6	9.8	-3.1	0.7	-2.6
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.2	0.1	-0.2	0.4
Ever used hormone-replacement therapy (HRT)	1.7	2.2	5.3	-0.9	0.7	-2.3
Ever had hysterectomy (womb removed)	1.1	1.3	2.2	-1.3	1.5	-0.1
Systolic blood pressure, automated reading	0.7	2.1	4.7	1.2	-0.3	2.2
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.4	0.1	0.7	1.6
Angina	0.1	0.1	0.2	-0.2	0.2	-0.4
Medication for hormone replacement therapy	0.1	0.1	0.2	0.0	-0.5	-0.0
Vitamin and mineral supplements	0.6	0.8	1.0	-0.8	1.0	0.9
Supplements: Zinc	2.3	2.5	6.5	2.5	0.4	0.9
Medication: Co-codamol	0.6	0.7	1.3	-0.5	-1.1	-0.8
Medication: Metformin	1.0	1.4	3.4	-0.7	1.9	0.3
Diabetes (father)	0.2	0.2	0.6	-0.0	0.0	-0.8
Diabetes (mother)	1.6	2.0	5.4	0.1	0.7	2.3
Severe depression (siblings)	1.2	1.4	3.1	-0.5	-0.8	1.8
Pack years adult smoking proportion	0.3	0.4	0.9	-0.7	-0.1	-0.9
Impedance of leg (right)	0.1	0.5	1.1	-1.0	-0.4	-0.3
Leg fat-free mass (left)	0.1	0.4	0.7	0.9	0.6	0.2
Trunk fat percentage	0.1	0.3	0.7	0.8	0.4	-0.2
Hand grip strength (right)	0.5	1.3	1.9	1.4	-1.1	0.9
Townsend deprivation index at recruitment	0.1	0.1	0.2	-0.3	-0.5	0.1
Current tobacco smoking	0.8	1.3	2.5	1.6	-0.7	-0.8
Average weekly fortified wine intake	2.4	2.8	5.3	2.3	0.6	1.7
Maternal smoking around birth	1.2	1.7	2.6	-0.5	-1.6	-1.5
Fed-up feelings	0.8	1.5	2.4	-1.3	0.7	-1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	1.9	-1.4	0.4	-1.0
Relative age voice broke	1.7	2.6	5.6	-2.4	1.1	-0.9
Taking other prescription medications	0.9	1.3	2.3	-1.5	-0.2	-1.3
Age when periods started (menarche)	1.1	2.7	5.5	1.2	1.0	2.3
Bilateral oophorectomy (both ovaries removed)	1.4	1.7	4.0	0.6	2.0	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.0	-0.4	-0.1	1.0
Tinnitus: Yes, but not now, but have in the past	0.2	0.3	0.5	0.0	0.6	0.7
Qualifications: CSEs or equivalent	1.2	1.5	1.8	-1.1	-1.3	1.3
Serious illness, injury or assault to yourself	1.7	2.0	4.1	2.0	-1.4	-0.2
High blood pressure	0.6	1.8	5.0	2.2	-0.4	0.3
Hayfever, allergic rhinitis or eczema	2.2	4.8	12.5	3.5	0.3	-1.3
Multivitamins +/- minerals	0.2	0.3	0.5	0.7	-0.6	-0.1
Stomach or abdominal pain in last month	0.4	0.6	1.1	0.6	-0.4	1.0
Supplements: Glucosamine	5.1	6.7	15.2	-2.2	0.2	-3.9
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.3	1.1	-0.4	0.2
Medication: Atenolol	0.1	0.1	0.2	0.4	0.3	0.4
Medication: Levothyroxine sodium	0.1	0.1	0.2	0.3	-0.4	0.5
Sitting height	0.3	2.1	4.4	-0.8	2.1	-1.0
Chronic bronchitis/emphysema (father)	0.1	0.1	0.3	-0.1	0.5	0.1
High blood pressure (mother)	2.5	3.5	5.2	1.4	1.8	2.3
Body mass index (BMI)	0.3	1.3	2.3	1.5	-1.2	0.2
Impedance of leg (left)	0.1	0.5	0.9	-1.0	-0.7	0.3
Leg predicted mass (left)	0.1	0.4	0.8	0.9	0.7	0.2
Trunk fat mass	0.1	0.4	0.9	1.0	0.6	0.3
Waist circumference	0.1	0.5	1.5	1.2	-0.0	0.2
Number of incorrect matches in round	0.7	1.1	2.2	-0.9	0.6	1.5
Past tobacco smoking	0.4	0.8	2.3	1.5	0.1	0.3
Alcohol usually taken with meals	0.9	1.5	2.4	0.7	1.5	1.3
Nervous feelings	0.7	1.2	1.8	0.8	1.1	-1.3
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.0	2.5	0.4	0.6	-1.6
Hearing difficulty/problems with background noise	0.9	1.4	4.1	-0.3	-0.1	-2.0
Hair/balding pattern: Pattern 2	1.7	2.1	4.4	1.2	2.1	0.7
Had menopause	1.1	1.4	2.1	-1.4	0.4	-1.5
Had other major operations	0.1	0.1	0.2	-0.0	-0.1	-0.4
Forced vital capacity (FVC)	0.3	1.0	1.5	-1.0	-0.7	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.3	0.1	-0.7	1.2
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.1	-1.1	-0.0	0.5
Qualifications: None of the above	0.3	0.6	1.8	0.2	1.3	-0.1
Financial difficulties in last 2 years	1.0	1.4	4.2	-2.0	0.1	0.1
Mouth/teeth dental problems	3.8	5.9	9.5	0.6	2.8	3.1
Heart attack	0.3	0.4	0.7	-0.7	-0.8	0.0
Allergy	0.9	2.1	4.5	-2.1	-0.9	1.0
Pain all over the body in last month	1.1	1.2	2.5	0.3	1.0	-1.6
Diabetes (self-reported)	0.2	0.3	0.4	-0.6	0.2	-0.6
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	3.5	1.9	-0.6	0.9
Medication: Ramipril	0.3	0.3	0.5	-0.7	-0.6	-0.4
Medication: Simvastatin	0.8	1.1	1.6	-0.8	1.3	-1.0
Fluid intelligence score	0.5	1.1	2.0	-0.4	-1.4	-1.1
Illnesses of siblings	0.2	0.3	0.5	-0.4	-0.7	-0.3
Neuroticism score	0.6	1.2	1.5	-1.1	1.2	-1.0
Weight	0.1	0.3	0.8	0.9	0.2	0.3
Impedance of arm (right)	0.5	2.4	4.5	-1.3	2.1	-1.0
Arm fat percentage (right)	0.1	0.4	1.2	1.1	0.1	-0.2
Trunk fat-free mass	0.1	0.6	1.4	1.2	0.2	0.6
Hip circumference	0.2	1.0	2.1	1.4	-0.1	1.0
Time employed in main current job	0.3	0.3	0.7	0.8	-0.3	-0.5
Alcohol intake versus 10 years previously	0.6	0.9	2.0	-1.4	0.3	-0.8
Father’s age at death	0.5	0.7	1.3	1.2	-0.1	-0.9
Worrier / anxious feelings	1.4	2.7	5.6	-0.4	2.4	-1.5
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.4	1.0	0.2	-1.2
Falls in the last year	1.1	1.5	2.8	-1.7	-1.3	0.3
Hair/balding pattern: Pattern 3	1.5	2.3	5.2	-1.0	-0.7	-2.3
Number of live births	1.1	1.5	3.0	1.1	-0.6	1.7
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.3	-1.2	-0.6	-0.4
Pulse rate	0.9	1.5	2.4	-1.4	-0.4	-1.5
Happiness	0.5	0.5	0.9	-0.2	1.0	-0.8
Noisy workplace	0.4	0.5	0.7	0.5	0.8	0.7
Qualifications: A levels/AS levels or equivalent	0.7	1.5	1.7	-1.2	-1.2	-1.3
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	3.2	-0.5	-0.3	-1.8
Mouth/teeth dental problems: Dentures	0.6	1.0	2.6	0.6	-1.6	-0.3
Asthma	0.5	0.9	1.3	-1.0	0.7	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.8	-0.1	-0.1	1.3
Medication: Cholesterol lowering	1.8	2.7	8.1	-2.8	-0.2	-0.3
Depression (self-reported)	0.5	0.6	1.3	-0.7	-0.2	-1.1
Medication: Lansoprazole	1.5	1.7	3.9	-0.4	2.0	1.0
Prospective memory result	1.0	1.3	2.9	0.1	0.9	-1.7
Lung cancer (father)	0.2	0.2	0.4	-0.4	0.6	0.2
Illnesses of mother	1.3	1.5	2.8	-1.2	-0.7	-1.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.8	2.3	-1.5	0.2	0.1
Pulse wave Arterial Stiffness index	0.8	1.0	2.6	1.6	0.4	0.3
Impedance of arm (left)	0.4	2.1	3.8	-1.4	2.0	-0.5
Arm fat mass (right)	0.2	0.8	2.2	1.5	-0.3	-0.3
Trunk predicted mass	0.1	0.5	1.3	1.2	0.1	0.5
Standing height	0.3	2.5	7.1	-0.6	2.7	0.3
Length of working week for main job	0.2	0.2	0.6	-0.3	-0.2	0.8
Exposure to tobacco smoke at home	0.1	0.1	0.2	-0.0	0.5	-0.0
Breastfed as a baby	0.9	1.2	3.2	0.4	0.3	-1.8
Tense / ‘highly strung’	0.4	0.7	1.1	0.1	0.9	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	3.7	0.0	-1.9	-1.2
Hair/balding pattern: Pattern 4	0.3	0.7	1.7	-0.5	-0.5	1.3
Birth weight of first child	0.1	0.2	0.3	0.5	-0.4	0.5
Peak expiratory flow (PEF)	1.5	3.5	10.2	-3.2	0.4	-0.2
Pulse wave reflection index	0.4	0.4	0.8	0.9	0.7	0.2
Ever highly irritable/argumentative for 2 days	1.2	1.4	3.0	-1.7	0.4	-1.1
Loud music exposure frequency	2.1	2.3	6.1	-2.5	0.1	-0.8
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	4.2	-0.0	-2.1	-1.7
Mouth/teeth dental problems: Bleeding gums	2.4	3.2	5.9	0.8	-2.4	-1.7
Blood clot in the leg (DVT)	0.5	0.6	0.8	0.6	0.9	0.8
Medication: Paracetamol	0.6	1.0	2.7	0.4	-0.2	1.7
Headache pain in last month	1.3	2.2	3.1	1.8	-0.7	1.7
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.1	1.5	0.2	-0.5
Glaucoma (self-reported)	0.0	0.1	0.1	0.1	0.4	0.1
Gout (self-reported)	0.6	0.8	1.2	-1.1	0.5	-1.0
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.5	-0.7	0.1	-0.0
Medication: Amlodipine	1.4	2.0	3.8	1.5	1.9	0.1
Medication: Ventolin 100micrograms inhaler	1.8	2.3	3.8	-2.0	1.4	1.1
Birth weight	0.7	1.6	3.6	1.1	-0.1	-1.9
Chronic bronchitis/emphysema (mother)	0.5	0.6	0.7	0.7	0.8	0.7
High blood pressure (siblings)	0.4	0.6	1.8	1.3	-0.2	-0.2
Forced vital capacity (FVC), Best measure	0.2	0.9	2.1	-1.4	0.2	-0.7
Body fat percentage	0.1	0.2	0.6	0.8	0.0	0.1
Leg fat percentage (right)	0.1	0.3	0.7	0.4	-0.9	0.0
Arm fat-free mass (right)	0.2	1.0	2.0	1.4	-0.2	1.0
Exposure to tobacco smoke outside home	1.9	2.6	2.9	-1.6	-1.5	-1.7
Comparative body size at age 10	0.3	0.8	1.6	1.3	-0.5	-0.8
Number of full brothers	1.6	2.0	4.5	0.4	-1.1	2.1
Worry too long after embarrassment	2.0	3.4	8.3	0.7	2.9	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	2.6	-1.0	0.1	-1.6
Wheeze or whistling in the chest in last year	0.1	0.2	0.7	0.0	0.1	0.8
Number of children fathered	1.1	1.3	2.3	-1.5	0.2	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.7	-0.1	-0.8	-0.4
Age at first live birth	0.6	1.1	1.7	0.7	-1.0	-1.3
Pulse wave peak to peak time	0.7	0.8	2.2	-1.5	-0.4	-0.4
Health satisfaction	0.6	0.8	1.0	-1.0	0.9	-0.7
Shortness of breath walking on level ground	1.1	1.3	2.7	-0.5	0.9	1.7
Qualifications: College or University degree	0.1	0.3	0.5	0.7	-0.6	0.1
Eye problems/disorders: None of the above	1.0	1.1	3.0	-1.7	0.2	0.6
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.3	0.5	-0.1	-0.5
Emphysema/chronic bronchitis	0.4	0.4	0.5	-0.7	-0.5	-0.7
Medication for pain relief, constipation, heartburn	1.2	2.0	3.2	0.1	1.7	-1.8
Neck or shoulder pain in last month	1.2	1.8	4.7	0.3	-2.2	0.7
Medication: Blood pressure	0.1	0.2	0.4	-0.2	-0.5	0.6
Angina (self-reported)	0.1	0.1	0.2	0.0	0.1	-0.4
Migraine (self-reported)	0.6	0.7	1.7	-0.2	1.3	-0.7
Medication: Ibuprofen	0.9	1.0	2.3	-0.5	-0.8	1.5
Medication: Allopurinol	0.1	0.1	0.4	-0.1	0.6	-0.2
Medication: Omeprazole	1.1	1.3	2.3	-1.2	-1.5	-0.2
Medication: Seretide 50 evohaler	0.1	0.1	0.2	0.4	-0.4	0.3
Mean time to correctly identify matches	1.5	2.8	5.8	-1.1	1.2	-2.4
Heart disease (mother)	0.1	0.1	0.2	0.3	0.1	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.5	0.3	0.3	1.2
Whole body fat mass	0.1	0.6	1.5	1.2	-0.0	0.4
Leg fat mass (right)	0.1	0.4	0.7	0.9	-0.6	0.2
Arm predicted mass (right)	0.2	1.1	2.4	1.5	-0.1	0.9
Pulse rate, automated reading	0.6	2.1	3.3	-0.8	-1.8	-1.5
Alcohol intake frequency.	1.9	4.4	8.2	-0.0	2.9	2.2
Comparative height size at age 10	0.4	2.1	5.5	-0.9	2.4	-0.2
Number of full sisters	3.9	4.7	13.5	0.7	0.4	3.7
Suffer from ‘nerves’	0.6	1.0	2.5	-0.3	0.5	-1.6
Overall health rating	0.2	0.3	0.7	0.5	-0.9	0.0
Chest pain or discomfort	0.7	1.0	1.6	-0.9	-1.3	-0.8
Had major operations	0.3	0.4	0.9	-1.0	-0.2	0.3
Age at last live birth	0.2	0.3	0.5	-0.4	-0.3	-0.7
Family relationship satisfaction	1.0	1.2	2.3	-1.5	0.8	-0.8
Leg pain on walking	0.4	0.5	1.2	-0.7	0.0	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	2.0	-0.3	-0.4	1.4
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.5	-0.3	1.2	0.1
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	3.6	0.3	1.9	0.3
Medication: Aspirin	1.0	1.3	2.5	-1.6	-1.2	-0.2
Supplements: Vitamin C	0.9	1.1	1.9	-1.0	-0.6	-1.4
Knee pain experienced in last month	0.7	1.1	3.0	-0.4	-1.7	-0.3
Hypertension (Self-reported)	0.5	1.5	4.0	2.0	-0.5	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	2.6	0.2	0.5	1.6
Illnesses of father: Heart disease	0.5	0.6	1.7	1.3	0.2	0.4
Illnesses of siblings: Diabetes	1.2	1.5	2.6	1.1	0.8	1.6
Smoking status: Previous	0.8	1.2	3.5	-1.9	-0.2	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.3	0.3	-0.6	0.5
Whole body fat-free mass	0.1	0.6	1.3	1.2	0.3	0.6
Leg fat-free mass (right)	0.1	0.4	0.5	0.7	0.7	0.5
Arm fat percentage (left)	0.1	0.3	0.9	0.9	0.1	0.0
Average weekly red wine intake	0.8	1.3	1.6	1.1	-1.2	1.0
Handedness (chirality/laterality): Left-handed	0.9	1.0	3.1	-0.2	0.0	1.8
Mood swings	0.3	0.5	1.4	-1.2	0.2	-0.4
Loneliness, isolation	0.2	0.2	0.3	-0.3	-0.5	-0.6
Long-standing illness, disability or infirmity	0.1	0.2	0.4	-0.3	-0.6	-0.4
Ever had bowel cancer screening	1.8	2.2	3.3	-0.3	1.8	-1.8
Diabetes diagnosed by doctor	0.1	0.2	0.3	-0.6	0.3	0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	4.0	-0.8	-2.0	0.1
Friendships satisfaction	0.1	0.1	0.2	-0.2	-0.4	0.3
Qualifications: nursing, teaching	0.4	0.6	1.0	-1.0	-0.8	0.3
Commuting to job workplace: Walk	1.6	1.7	3.6	-0.5	-1.1	-1.9
Eye problems/disorders: Cataract	0.5	0.5	1.0	1.0	-0.8	0.1
Mouth/teeth dental problems: Mouth ulcers	4.8	7.7	10.8	-2.5	-2.4	-3.3
Medication for cholesterol	1.5	2.3	6.8	-2.6	-0.2	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.0	3.5	6.8	2.6	-0.6	-1.8
Back pain experienced in last month	0.6	0.9	1.6	0.4	-1.3	-1.0
Mineral and other dietary supplements	1.1	1.4	3.3	0.4	0.9	1.8
Breast cancer (self-reported)	0.6	0.7	1.7	0.1	-0.5	1.3
Asthma (self-reported)	0.5	0.9	1.0	-0.8	1.0	1.0
Osteoporosis (self-reported)	0.5	0.6	1.6	-1.3	0.2	-0.3
Osteoarthritis (self-reported)	0.1	0.2	0.2	-0.4	0.5	0.4
Medication: Aspirin	0.5	0.7	1.3	-1.1	-0.8	-0.4
Medication: Gliclazide	0.4	0.4	0.6	0.6	0.4	0.8
Illnesses of father: None of the above (group 1)	0.3	0.4	0.9	0.0	-0.5	1.0
Smoking status: Current	0.9	1.4	3.7	1.9	-0.7	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.4	-0.7	-0.2	0.3
Whole body water mass	0.1	0.6	1.6	1.2	0.2	0.5
Leg predicted mass (right)	0.1	0.5	0.7	0.8	0.7	0.5
Arm fat mass (left)	0.2	0.6	1.8	1.4	-0.0	-0.2
Number of self-reported non-cancer illnesses	0.2	0.4	0.6	-0.7	-0.4	-0.6
Average weekly champagne plus white wine intake	0.9	1.3	2.3	-1.5	0.1	-1.3
Miserableness	0.9	1.6	3.1	-1.8	-0.8	-1.0
Guilty feelings	0.8	1.3	1.5	-1.0	1.1	-1.2
Wears glasses or contact lenses	1.1	1.3	2.0	-0.9	1.4	-0.9
Ever taken oral contraceptive pill	0.6	0.7	1.5	-0.5	-1.2	0.6
Hearing aid user	0.5	0.6	1.1	0.7	-1.1	0.3
Mother’s age at death	0.5	0.6	0.9	-0.9	-0.8	0.6
Financial situation satisfaction	0.1	0.1	0.2	-0.5	-0.2	-0.3
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.0	-0.1	1.0	-0.6
Commuting to job workplace: Public transport	1.8	2.2	5.3	-1.0	-2.3	0.3
Eye problems/disorders: Glaucoma	0.7	0.8	1.8	1.3	0.8	0.3
Medication: Blood pressure	1.4	2.7	7.6	2.8	0.4	0.5
Pain type(s) experienced in last month: Hip pain	2.4	3.0	8.6	-0.5	-0.6	-2.9
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.3	0.4	-0.6	-0.2
High cholesterol (Self-reported)	0.8	1.4	2.3	-1.5	0.6	-1.2
Medication: Bendroflumethiazide	1.1	1.7	4.3	2.1	0.5	0.7
Medication: Paracetamol	1.0	1.5	3.2	1.0	-0.5	1.8
Medication: Lisinopril	0.2	0.3	0.5	0.4	0.4	-0.7
Medication: Atorvastatin	0.6	0.7	1.3	-1.2	-0.6	-0.6
Illnesses of father: High blood pressure	0.3	0.4	0.6	-0.7	-0.8	-0.3
Alcohol drinker status: Never	1.1	1.3	1.8	0.5	1.3	1.3
Ever smoked	0.2	0.3	0.6	-0.6	-0.8	0.4
Basal metabolic rate	0.1	0.6	1.6	1.2	0.2	0.6
Leg fat percentage (left)	0.1	0.5	0.9	0.5	-0.9	0.6
Arm fat-free mass (left)	0.2	1.1	3.1	1.8	-0.1	0.5
Number of operations (self-reported)	0.6	0.9	1.9	-0.8	0.3	-1.4
Average weekly beer plus cider intake	1.2	1.7	2.6	-0.4	-1.6	-1.5
Irritability	1.5	2.6	6.8	-0.7	-0.7	-2.6
Risk taking	0.9	1.4	3.8	0.5	-1.9	0.1
Ever had prostate specific antigen (PSA) test	1.2	1.4	3.5	-0.7	0.3	-1.9
Fractured/broken bones in last 5 years	2.0	2.6	4.4	-2.1	-0.9	-1.6
Age started oral contraceptive pill	0.2	0.3	0.7	-0.1	0.8	-0.4
Diastolic blood pressure, automated reading	0.8	2.4	3.7	1.9	-1.9	0.4
Ever depressed for a whole week	0.7	0.9	2.1	-1.5	-0.7	0.3
Unable to work because of sickness or disability	0.9	1.1	2.5	-0.2	-0.9	-1.6
Commuting to job workplace: Cycle	0.1	0.1	0.2	-0.5	-0.1	0.1
Myopia	0.8	1.2	2.5	-1.6	-0.8	0.6
Vascular/heart problems diagnosed by doctor	0.6	1.5	4.1	-2.0	0.1	-0.7
Cholesterol lowering medication	1.2	1.7	4.2	0.7	2.0	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.6	-0.1	-0.6	0.8
Pain experienced in last month	0.9	1.5	2.3	-1.3	1.5	0.6
Supplements: Calcium	0.8	0.9	2.5	-0.2	0.4	-1.6
Basal cell carcinoma (self-reported)	0.9	1.0	2.3	-0.4	1.5	-0.8
Heart attack/myocardial infarction (self-reported)	0.3	0.3	0.6	-0.7	-0.8	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	0.9	0.8	1.0	0.9
Heart disease (siblings)	0.3	0.4	0.7	-0.5	0.6	0.8
Alcohol drinker status: Previous	0.4	0.4	0.6	0.7	0.4	0.8
Pack years of smoking	0.3	0.5	1.1	-0.6	0.2	-1.1
Impedance of whole body	0.2	1.0	1.6	-1.3	1.2	-0.3
Leg fat mass (left)	0.1	0.5	0.9	0.9	-0.5	0.6
Arm predicted mass (left)	0.2	0.8	2.3	1.5	-0.2	0.4