Hub : Genes

FGL1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1520	0.0330	2.3e-11	0.098	0.110	0.141	0.120	0.132	6.6e-12	2.8e-13	7.4e-17	1.9e-14	9.0e-16
2	ROSMAP	Brain Pre-frontal Cortex	0.2337	0.0385	0.0e+00	0.167	0.185	0.205	0.215	0.220	6.6e-21	2.9e-23	8.1e-26	4.4e-27	7.5e-28
3	TCGA	Breast Invasive Carcinoma	0.0287	0.0162	6.7e-04	0.004	0.004	0.008	NA	0.009	3.7e-02	4.8e-02	6.6e-03	NA	4.2e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.6	0.9	1.3	1.1	0.8	-0.9
Bipolar Disorder or Schizophrenia	0.3	0.8	1.8	1.3	0.6	0.6
Depressed Affect (Nagel 2018)	0.1	0.2	0.4	0.3	0.6	-0.5
Depression (Nagel 2018)	0.3	0.4	1.2	0.0	-0.1	-1.1
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.0	0.4	0.4	-1.0
Neuroticism (Nagel 2018)	0.6	1.3	1.9	1.4	1.2	-0.8
Schizophrenia (2018)	0.5	1.0	2.4	0.9	0.0	1.5
Schizophrenia vs Biploar Disorder	2.1	2.7	4.7	-1.2	-1.4	2.2
Worry (Nagel 2018)	0.8	1.7	2.8	1.7	1.3	-0.7
Alzheimer’s Disease (in mother)	0.5	0.6	1.3	0.3	-0.7	1.1
Alzheimer’s Disease (in father)	0.6	0.7	0.9	1.0	0.7	0.7
Alzheimer’s Disease (including proxy)	0.5	0.7	1.3	0.7	-0.6	1.1
Crohns Disease (2017)	1.0	2.2	6.2	-0.3	-0.4	2.5
Irritable Bowel Disease (IBD)	0.3	0.6	1.8	0.2	0.2	1.4
Ulcerative Colitis (UC)	0.2	0.3	0.6	0.8	0.5	-0.2
Major Depression (MDD)	0.9	1.1	2.9	-1.7	-0.6	0.0
Reaction Time	0.0	0.1	0.2	0.5	-0.2	0.1
Verbal and Numeric Reasoning (VNR)	0.8	2.0	5.6	0.6	-0.1	-2.4
Breast Cancer	1.9	4.6	13.0	-0.8	-0.2	3.6
Ovarian Cancer	0.2	0.3	0.5	0.7	-0.6	-0.3
Prostate Cancer	0.2	0.3	0.9	0.9	0.1	-0.3
Age at First Birth	0.2	0.4	0.5	0.4	0.6	-0.7
Bipolar Disorder (2011)	1.0	0.9	2.4	0.5	-0.3	1.6
Body Mass Index (BMI) (2010)	0.8	1.1	3.1	0.1	0.5	-1.8
Coronary Artery Disease (CAD)	0.5	0.6	1.0	0.6	-0.7	1.0
Crohns Disease (2012)	0.4	0.6	1.7	-0.1	0.1	1.3
Mean Putamen Volume	0.5	0.6	1.4	-0.3	0.6	1.2
Fasting Glucose	0.4	0.5	0.8	-0.6	-0.9	0.7
HbA1C	0.2	0.2	0.4	0.6	0.4	0.0
HDL Cholesterol	0.9	1.4	1.7	1.3	1.3	-1.0
LDL Cholesterol	0.1	0.1	0.3	-0.2	-0.5	0.4
Lupus	0.7	1.0	1.5	1.2	0.9	0.8
Neuroticism (2016)	1.2	1.7	3.1	1.4	1.8	0.5
Primary Biliary Cirrhosis	0.9	1.3	2.7	-0.2	-1.6	1.1
Rheumatoid Arthritis	0.3	0.4	1.1	-0.2	0.3	1.1
Schizophrenia (2014)	0.6	1.4	3.9	0.4	-0.3	2.0
Triglycerides	1.4	2.2	5.1	-1.3	-2.2	0.0
Type 2 Diabetes (T2D) (2012)	3.3	3.9	6.2	-2.5	-1.9	1.4
Ulcerative Colitis	0.7	0.9	1.1	1.1	0.8	-1.0
Blood Eosinophil Count	0.2	1.2	1.5	-1.1	-1.0	1.2
Blood Platelet Count	0.2	1.8	2.7	-1.4	-1.0	-1.6
Blood Red Count	0.0	0.1	0.3	-0.6	0.0	-0.2
Blood White Count	0.6	4.7	8.1	-2.9	-2.0	1.3
Heel T-Score	0.0	0.3	0.6	0.7	0.6	0.1
BMI	0.1	0.8	1.3	0.1	-1.1	1.1
Height	0.6	11.3	30.4	0.4	1.8	-5.5
Waist Hip Ratio (WHR)	2.1	9.4	14.7	-3.3	-3.8	1.5
Systolic Blood Pressure	0.0	0.2	0.5	0.2	0.1	0.7
Smoking Status	2.7	6.4	7.7	-2.2	-2.8	2.6
Allergy or Eczema	0.2	0.5	0.9	-0.8	-0.1	1.0
Cardiovascular Disease	0.3	1.0	2.1	1.4	-0.2	1.0
Hypothyroidism (self reported)	0.9	2.0	2.7	1.6	1.6	0.9
Respiratory disease	0.2	0.5	1.0	0.3	1.0	0.6
Type 2 Diabetes (T2D) (2018)	1.0	2.0	2.9	-0.5	-1.7	1.7
Lung FEV1/FVC ratio	9.9	50.4	74.1	-5.6	-6.8	8.6
Lung FVC	0.3	1.6	2.5	0.6	1.3	-1.6
Neuroticism	0.8	1.9	3.2	1.8	1.1	-1.2
Chronotype (morning person)	3.0	7.0	8.2	2.3	2.8	-2.9
Hair Pigment	0.0	0.8	2.0	0.6	-0.1	-1.4
Tanning	0.0	0.4	0.9	-0.9	0.2	0.5
Hand grip strength (left)	1.8	4.8	5.0	-2.2	-2.2	2.1
Number of treatments/medications taken	0.4	0.7	1.8	-0.1	0.6	1.4
Average weekly spirits intake	0.3	0.4	0.7	-0.6	-0.8	-0.4
Sensitivity / hurt feelings	1.8	3.1	3.5	1.9	1.7	-1.7
Frequency of depressed mood in last 2 weeks	0.6	0.9	1.3	0.5	1.2	-1.0
Hearing difficulty/problems: Yes	0.0	0.1	0.2	-0.1	-0.5	0.0
Relative age of first facial hair	2.0	4.2	4.9	-2.2	-1.9	2.1
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	2.7	0.4	0.5	1.6
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.3	-0.8	-0.1	1.2
Ever had hysterectomy (womb removed)	1.0	1.1	1.4	-1.2	-1.2	0.8
Systolic blood pressure, automated reading	0.2	0.6	1.3	-0.7	-0.4	1.1
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.0	0.0	0.8	1.4
Angina	0.1	0.1	0.2	-0.0	-0.4	0.5
Medication for hormone replacement therapy	1.2	1.4	3.8	0.3	0.4	2.0
Vitamin and mineral supplements	0.5	0.7	1.5	-0.0	-0.9	1.2
Supplements: Zinc	2.8	3.0	4.7	1.3	2.2	-1.7
Medication: Co-codamol	1.1	1.3	3.7	-0.3	-0.2	-1.9
Medication: Metformin	0.7	1.1	2.4	-0.3	-0.8	1.6
Diabetes (father)	0.4	0.5	1.2	-0.6	0.3	1.1
Diabetes (mother)	1.4	1.8	3.2	-1.8	-0.7	1.4
Severe depression (siblings)	0.1	0.2	0.2	0.3	0.4	-0.5
Pack years adult smoking proportion	1.1	1.7	4.6	-0.6	-0.3	2.1
Impedance of leg (right)	0.1	0.3	0.4	0.6	-0.1	-0.7
Leg fat-free mass (left)	0.0	0.2	0.4	-0.5	-0.2	-0.6
Trunk fat percentage	0.4	1.5	3.7	1.0	-0.0	-1.9
Hand grip strength (right)	0.9	2.6	2.8	-1.7	-1.5	1.6
Townsend deprivation index at recruitment	3.9	5.4	9.5	-1.8	-1.9	3.1
Current tobacco smoking	2.1	3.5	5.1	-1.7	-1.5	2.3
Average weekly fortified wine intake	0.8	1.0	1.5	1.2	1.0	-0.7
Maternal smoking around birth	0.3	0.5	0.5	-0.7	-0.6	0.7
Fed-up feelings	0.6	1.1	2.0	0.6	0.9	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.1	0.0	0.0	-0.3
Relative age voice broke	1.3	2.0	3.1	-1.3	-1.1	1.8
Taking other prescription medications	1.0	1.6	3.7	-0.9	-0.5	1.9
Age when periods started (menarche)	0.5	1.3	2.2	1.1	1.5	0.7
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.3	-0.0	-0.3	1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.7	-0.8	-0.7	-0.2
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	3.0	-1.3	-1.7	-0.7
Qualifications: CSEs or equivalent	2.1	2.7	3.3	-1.8	-1.3	1.8
Serious illness, injury or assault to yourself	1.6	1.9	3.0	-1.7	-1.4	0.8
High blood pressure	0.9	2.5	6.8	2.6	0.9	-0.1
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.5	-1.2	0.1	0.6
Multivitamins +/- minerals	0.4	0.6	1.6	-1.3	-0.3	-0.1
Stomach or abdominal pain in last month	1.4	1.8	4.0	-1.1	-2.0	-0.4
Supplements: Glucosamine	2.6	3.4	4.6	1.5	2.2	-1.8
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.0	-0.4	-0.9	-1.0
Medication: Atenolol	0.3	0.3	0.5	0.7	0.7	0.1
Medication: Levothyroxine sodium	1.7	2.9	4.4	2.1	2.0	0.3
Sitting height	0.1	0.4	0.5	-0.6	0.6	-0.7
Chronic bronchitis/emphysema (father)	0.2	0.3	0.5	-0.7	0.5	0.3
High blood pressure (mother)	1.7	2.4	4.1	-0.8	-1.5	2.0
Body mass index (BMI)	0.0	0.1	0.2	-0.1	-0.5	0.3
Impedance of leg (left)	0.0	0.2	0.3	0.3	-0.4	-0.6
Leg predicted mass (left)	0.0	0.2	0.5	-0.4	-0.1	-0.7
Trunk fat mass	0.3	1.2	2.8	0.8	0.1	-1.7
Waist circumference	0.3	1.1	1.8	-1.2	-1.3	0.2
Number of incorrect matches in round	3.8	6.4	8.4	-2.9	-2.8	1.6
Past tobacco smoking	0.5	0.9	2.2	0.6	1.5	-0.4
Alcohol usually taken with meals	2.3	3.7	4.3	2.1	2.0	-1.7
Nervous feelings	0.3	0.6	1.3	0.8	1.1	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.3	0.5	0.5	-0.6
Hearing difficulty/problems with background noise	0.1	0.2	0.4	-0.0	0.3	-0.6
Hair/balding pattern: Pattern 2	2.3	2.9	6.2	1.2	1.0	-2.5
Had menopause	0.5	0.6	1.5	0.5	-0.0	-1.2
Had other major operations	0.4	0.5	0.8	-0.1	-0.8	-0.9
Forced vital capacity (FVC)	0.3	1.0	2.4	0.4	0.6	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.0	0.1	-0.1	0.0	0.3
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.1	-0.3	-1.0	0.8
Qualifications: None of the above	1.2	2.5	3.9	-1.5	-1.1	2.0
Financial difficulties in last 2 years	1.0	1.3	3.0	0.6	0.7	1.7
Mouth/teeth dental problems	0.5	0.8	1.9	0.6	1.4	0.1
Heart attack	0.5	0.6	0.9	-0.4	-0.9	0.9
Allergy	0.1	0.3	0.9	1.0	0.0	0.2
Pain all over the body in last month	0.2	0.2	0.3	0.5	-0.3	-0.6
Diabetes (self-reported)	1.6	2.5	5.0	-1.0	-1.2	2.2
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	4.1	0.3	0.7	2.0
Medication: Ramipril	0.9	1.1	2.3	-0.3	-1.0	-1.5
Medication: Simvastatin	1.6	2.4	4.8	-1.1	-1.1	2.2
Fluid intelligence score	0.1	0.3	0.8	0.0	-0.2	-0.9
Illnesses of siblings	0.2	0.3	0.7	-0.8	0.1	-0.4
Neuroticism score	1.2	2.5	3.6	1.7	1.9	-0.9
Weight	0.1	0.3	0.8	0.2	0.0	-0.9
Impedance of arm (right)	0.3	1.5	4.1	0.6	-0.0	-2.0
Arm fat percentage (right)	0.1	0.4	1.1	0.3	-0.2	-1.0
Trunk fat-free mass	0.0	0.2	0.6	-0.8	0.0	-0.0
Hip circumference	0.2	0.7	1.5	0.4	0.6	-1.2
Time employed in main current job	1.8	2.1	3.7	1.5	1.9	-0.5
Alcohol intake versus 10 years previously	2.1	3.2	5.4	-2.3	-2.0	0.3
Father’s age at death	0.9	1.2	1.5	1.0	1.2	-1.1
Worrier / anxious feelings	4.3	8.1	8.9	3.0	2.8	-2.7
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.2	-0.2	0.4	-1.1
Falls in the last year	0.8	1.1	2.1	-0.6	-0.9	1.5
Hair/balding pattern: Pattern 3	1.1	1.7	2.2	-1.3	-1.1	1.5
Number of live births	1.2	1.7	3.5	0.7	1.1	-1.9
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	1.5	-1.2	-1.1	0.8
Pulse rate	0.9	1.6	2.7	1.3	1.6	0.5
Happiness	0.1	0.1	0.1	0.2	0.4	-0.1
Noisy workplace	3.9	4.8	6.8	-2.6	-2.4	-1.3
Qualifications: A levels/AS levels or equivalent	2.0	4.4	12.5	0.7	0.4	-3.5
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.7	-0.6	0.2	-0.8
Mouth/teeth dental problems: Dentures	0.9	1.6	2.5	-0.8	-1.6	1.3
Asthma	0.2	0.5	1.0	-0.7	-0.2	1.0
Medication: Ibuprofen (e.g. Nurofen)	4.1	5.2	10.0	-3.2	-1.6	1.7
Medication: Cholesterol lowering	0.7	1.0	2.9	0.1	-0.4	1.7
Depression (self-reported)	1.3	1.6	1.8	1.3	1.4	-1.1
Medication: Lansoprazole	0.6	0.7	1.9	0.1	1.4	0.3
Prospective memory result	0.7	0.9	2.5	-1.6	-0.2	0.2
Lung cancer (father)	0.2	0.2	0.5	0.3	0.1	-0.7
Illnesses of mother	1.4	1.7	5.1	0.3	0.0	-2.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.1	-0.4	-0.1	-0.3
Pulse wave Arterial Stiffness index	0.8	1.0	1.2	0.8	1.1	1.0
Impedance of arm (left)	0.7	3.1	7.6	1.1	0.6	-2.8
Arm fat mass (right)	0.1	0.3	0.7	0.1	-0.4	-0.8
Trunk predicted mass	0.0	0.2	0.6	-0.8	0.0	-0.1
Standing height	0.2	2.4	6.7	0.3	0.7	-2.6
Length of working week for main job	0.3	0.4	0.9	-0.5	0.0	1.0
Exposure to tobacco smoke at home	0.7	0.7	1.4	0.4	0.8	1.2
Breastfed as a baby	2.9	3.6	5.0	1.5	1.8	-2.2
Tense / ‘highly strung’	0.5	0.8	1.8	-0.4	-0.6	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.3	0.0	0.2	0.6
Hair/balding pattern: Pattern 4	0.3	0.8	2.0	0.5	-0.5	1.4
Birth weight of first child	0.3	0.5	1.2	-0.3	-0.3	-1.1
Peak expiratory flow (PEF)	0.4	0.9	1.6	-1.2	-0.9	0.5
Pulse wave reflection index	0.2	0.3	0.9	-0.1	-0.1	0.9
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.1	-1.0	-1.0	0.5
Loud music exposure frequency	0.9	1.0	2.1	-0.9	-1.5	0.3
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	3.6	-0.4	-0.4	-1.9
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.5	-0.4	-0.7	0.2
Blood clot in the leg (DVT)	1.5	1.9	3.7	-0.5	-1.3	-1.9
Medication: Paracetamol	0.6	1.0	2.8	0.1	-0.3	-1.7
Headache pain in last month	0.2	0.4	0.8	0.6	0.9	0.3
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	0.9	-0.6	-0.3	-1.0
Glaucoma (self-reported)	0.1	0.2	0.3	0.3	0.1	0.6
Gout (self-reported)	2.0	2.8	3.5	-1.6	-1.5	1.9
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	2.2	1.1	1.5	1.1
Medication: Amlodipine	4.9	6.8	13.9	-2.6	-3.7	-0.3
Medication: Ventolin 100micrograms inhaler	0.3	0.3	0.6	-0.7	0.0	0.7
Birth weight	0.7	1.4	3.1	0.6	1.8	-0.9
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	0.3	0.3	-0.4
High blood pressure (siblings)	0.9	1.3	2.6	1.6	1.1	0.2
Forced vital capacity (FVC), Best measure	0.7	2.7	6.2	0.9	1.1	-2.5
Body fat percentage	0.3	1.1	2.3	1.0	-0.0	-1.5
Leg fat percentage (right)	0.1	0.3	0.8	0.9	0.2	-0.3
Arm fat-free mass (right)	0.0	0.1	0.1	0.0	0.4	-0.4
Exposure to tobacco smoke outside home	1.1	1.4	2.5	1.3	1.6	-0.0
Comparative body size at age 10	0.1	0.3	1.0	-0.0	-0.1	-1.0
Number of full brothers	1.7	2.1	5.0	-2.2	-0.8	0.9
Worry too long after embarrassment	4.9	8.2	12.8	2.9	3.6	-1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.3	1.2	0.6	1.0
Wheeze or whistling in the chest in last year	0.4	0.7	1.7	-0.6	0.4	1.3
Number of children fathered	0.0	0.0	0.1	-0.1	-0.0	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.3	-0.1	0.2	0.6
Age at first live birth	0.5	1.0	1.6	1.3	1.1	-0.1
Pulse wave peak to peak time	1.1	1.3	1.5	-0.9	-1.2	-1.2
Health satisfaction	0.6	0.7	1.0	0.9	1.0	-0.6
Shortness of breath walking on level ground	2.1	2.5	3.5	1.8	1.9	-0.8
Qualifications: College or University degree	3.0	9.4	11.7	3.1	3.4	-2.7
Eye problems/disorders: None of the above	0.1	0.1	0.2	-0.2	-0.4	-0.1
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.2	0.4	0.5	-0.4
Emphysema/chronic bronchitis	1.2	1.3	2.5	0.9	1.6	-0.8
Medication for pain relief, constipation, heartburn	1.6	2.7	4.4	2.1	1.7	-0.9
Neck or shoulder pain in last month	0.3	0.4	0.5	-0.6	-0.6	0.7
Medication: Blood pressure	0.1	0.2	0.3	0.6	-0.3	-0.5
Angina (self-reported)	0.0	0.1	0.1	0.1	-0.2	0.3
Migraine (self-reported)	1.6	2.0	5.6	0.0	0.7	2.4
Medication: Ibuprofen	1.9	2.3	5.3	-2.3	-0.7	1.0
Medication: Allopurinol	0.3	0.4	1.0	-0.1	-0.2	1.0
Medication: Omeprazole	0.5	0.6	1.6	-0.2	-1.3	-0.4
Medication: Seretide 50 evohaler	0.5	0.5	1.5	0.0	0.3	1.2
Mean time to correctly identify matches	0.7	1.3	2.7	1.6	1.0	-0.6
Heart disease (mother)	0.5	0.7	1.7	0.3	1.3	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.4	-0.4	-0.2	-0.6
Whole body fat mass	0.2	0.7	1.6	0.6	-0.3	-1.3
Leg fat mass (right)	0.0	0.1	0.2	0.2	-0.4	-0.4
Arm predicted mass (right)	0.0	0.0	0.1	-0.4	0.0	-0.1
Pulse rate, automated reading	0.2	0.6	1.0	0.4	0.9	-1.0
Alcohol intake frequency.	0.5	1.3	2.6	-0.6	0.9	1.6
Comparative height size at age 10	0.9	4.8	11.6	1.1	1.3	-3.4
Number of full sisters	1.5	1.8	2.7	-1.7	-1.6	0.2
Suffer from ‘nerves’	0.9	1.4	3.3	1.0	1.8	-0.1
Overall health rating	0.4	0.9	1.3	1.1	0.9	-0.7
Chest pain or discomfort	0.2	0.2	0.6	0.1	0.8	-0.4
Had major operations	0.1	0.1	0.1	-0.3	0.0	-0.3
Age at last live birth	0.1	0.2	0.5	0.7	0.1	0.1
Family relationship satisfaction	0.9	1.1	2.0	-1.1	-1.4	-0.0
Leg pain on walking	0.5	0.6	0.9	-0.5	-0.9	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.3	0.5	0.5	0.1
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.6	-0.3	-0.1	-1.3
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.3	1.2	-0.0	-1.0
Medication: Aspirin	0.7	0.9	2.3	-0.6	0.2	1.5
Supplements: Vitamin C	1.1	1.3	2.2	1.2	1.5	-0.5
Knee pain experienced in last month	0.1	0.2	0.3	-0.5	-0.2	0.4
Hypertension (Self-reported)	1.0	2.6	6.9	2.6	1.0	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	0.3	-0.5	-0.0
Illnesses of father: Heart disease	0.4	0.6	1.1	-1.0	-0.3	0.8
Illnesses of siblings: Diabetes	0.4	0.5	1.4	-0.4	-1.2	0.3
Smoking status: Previous	0.1	0.2	0.6	-0.2	-0.7	-0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.5	-0.4	0.7	-0.1
Whole body fat-free mass	0.0	0.2	0.4	-0.6	-0.0	-0.3
Leg fat-free mass (right)	0.1	0.3	0.5	-0.7	-0.3	-0.6
Arm fat percentage (left)	0.1	0.6	1.5	0.5	-0.0	-1.2
Average weekly red wine intake	0.5	0.7	1.1	-0.4	-1.1	-0.9
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	0.4	-0.3	-0.1
Mood swings	0.1	0.2	0.5	-0.0	0.7	0.3
Loneliness, isolation	0.2	0.2	0.5	0.3	-0.1	-0.7
Long-standing illness, disability or infirmity	0.4	0.6	1.3	0.6	1.1	0.2
Ever had bowel cancer screening	0.6	0.7	2.1	0.0	0.1	-1.5
Diabetes diagnosed by doctor	1.0	1.7	2.7	-0.5	-1.4	1.7
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	-0.1	0.2	-0.4
Friendships satisfaction	0.1	0.2	0.3	0.6	-0.4	-0.3
Qualifications: nursing, teaching	1.0	1.6	3.5	0.7	0.8	-1.9
Commuting to job workplace: Walk	1.3	1.4	2.0	-1.0	-1.4	1.2
Eye problems/disorders: Cataract	0.5	0.6	1.1	1.1	0.5	-0.7
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	4.9	0.7	0.2	-2.2
Medication for cholesterol	4.4	6.6	18.9	0.4	0.9	-4.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	0.6	0.8	0.7	-0.6
Back pain experienced in last month	0.1	0.2	0.6	-0.8	-0.2	0.2
Mineral and other dietary supplements	2.5	3.4	7.8	-1.0	-1.2	2.8
Breast cancer (self-reported)	1.1	1.3	3.7	0.3	-0.4	-1.9
Asthma (self-reported)	0.2	0.4	0.9	-0.6	-0.2	1.0
Osteoporosis (self-reported)	2.1	2.6	3.4	1.5	1.9	-1.5
Osteoarthritis (self-reported)	0.0	0.0	0.1	-0.0	-0.1	-0.3
Medication: Aspirin	0.9	1.2	3.4	-0.6	0.1	1.8
Medication: Gliclazide	0.2	0.3	0.8	-0.1	0.3	0.9
Illnesses of father: None of the above (group 1)	0.4	0.6	0.9	0.9	0.1	-0.9
Smoking status: Current	2.4	3.8	5.4	-1.8	-1.7	2.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	0.8	-0.4	-0.9	0.3
Whole body water mass	0.0	0.1	0.4	-0.6	0.0	-0.2
Leg predicted mass (right)	0.1	0.3	0.5	-0.7	-0.3	-0.5
Arm fat mass (left)	0.1	0.3	0.8	0.0	-0.2	-0.9
Number of self-reported non-cancer illnesses	0.6	1.0	1.5	1.0	0.8	1.2
Average weekly champagne plus white wine intake	0.1	0.1	0.2	0.4	-0.3	-0.4
Miserableness	0.2	0.3	0.6	0.2	0.8	0.3
Guilty feelings	0.6	1.0	1.6	-0.5	-1.0	1.3
Wears glasses or contact lenses	0.4	0.5	1.4	0.0	-0.3	-1.2
Ever taken oral contraceptive pill	2.3	2.5	4.7	-2.2	-1.4	0.9
Hearing aid user	0.3	0.3	0.5	0.2	0.6	-0.7
Mother’s age at death	0.7	0.9	1.9	0.5	0.8	1.4
Financial situation satisfaction	0.5	0.6	1.5	0.5	1.2	0.1
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.9	-0.9	-0.4	-0.1
Commuting to job workplace: Public transport	1.6	1.9	2.6	1.6	1.3	1.2
Eye problems/disorders: Glaucoma	0.3	0.3	0.9	-0.2	-0.1	1.0
Medication: Blood pressure	0.4	0.7	1.3	0.8	0.0	1.2
Pain type(s) experienced in last month: Hip pain	0.5	0.7	1.3	-0.8	-1.1	0.3
Supplements: Fish oil (including cod liver oil)	0.7	1.0	2.4	0.1	-0.6	-1.6
High cholesterol (Self-reported)	0.9	1.6	4.9	-0.2	-0.1	2.2
Medication: Bendroflumethiazide	0.3	0.4	1.0	-0.3	-1.0	-0.5
Medication: Paracetamol	0.2	0.4	1.0	0.3	0.1	-1.0
Medication: Lisinopril	2.4	3.1	4.3	2.1	1.9	-1.1
Medication: Atorvastatin	1.3	1.6	3.1	0.8	1.1	1.8
Illnesses of father: High blood pressure	0.1	0.1	0.3	0.0	-0.2	-0.5
Alcohol drinker status: Never	0.2	0.3	0.5	-0.1	0.5	0.7
Ever smoked	0.3	0.5	1.5	-0.2	-1.2	0.2
Basal metabolic rate	0.0	0.1	0.2	-0.5	0.0	-0.4
Leg fat percentage (left)	0.1	0.2	0.5	0.7	0.1	-0.3
Arm fat-free mass (left)	0.0	0.1	0.1	-0.2	0.3	0.3
Number of operations (self-reported)	0.1	0.2	0.4	-0.6	-0.2	-0.5
Average weekly beer plus cider intake	6.3	9.1	12.4	-2.6	-3.5	2.8
Irritability	0.1	0.1	0.2	0.3	0.4	-0.4
Risk taking	0.2	0.3	0.6	-0.2	-0.8	0.3
Ever had prostate specific antigen (PSA) test	8.6	9.9	12.2	2.8	3.5	-3.1
Fractured/broken bones in last 5 years	1.2	1.5	2.8	-1.7	-1.3	0.1
Age started oral contraceptive pill	0.6	0.7	1.3	1.2	0.7	0.5
Diastolic blood pressure, automated reading	1.5	4.8	6.7	2.0	1.9	-2.6
Ever depressed for a whole week	2.9	3.6	4.2	-1.7	-2.1	1.9
Unable to work because of sickness or disability	0.2	0.2	0.3	-0.3	-0.5	0.5
Commuting to job workplace: Cycle	0.7	0.8	1.7	-0.1	0.8	-1.3
Myopia	0.2	0.3	0.7	0.3	0.3	-0.8
Vascular/heart problems diagnosed by doctor	0.6	1.7	4.5	-2.1	-0.4	-0.5
Cholesterol lowering medication	3.0	4.4	8.3	-1.8	-1.3	2.9
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	1.8	-0.2	-1.3	-0.7
Pain experienced in last month	0.1	0.1	0.3	0.1	-0.2	0.6
Supplements: Calcium	2.8	3.0	3.5	1.6	1.9	-1.8
Basal cell carcinoma (self-reported)	0.6	0.7	1.6	0.5	-0.6	-1.3
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.0	-0.3	-0.8	1.0
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	3.5	-0.6	-1.2	-1.9
Heart disease (siblings)	0.1	0.1	0.2	-0.4	-0.0	0.2
Alcohol drinker status: Previous	0.4	0.5	1.0	-0.5	-1.0	0.3
Pack years of smoking	0.9	1.4	4.0	-0.2	-0.2	2.0
Impedance of whole body	0.3	1.7	3.8	1.2	0.3	-1.9
Leg fat mass (left)	0.0	0.2	0.2	0.2	-0.5	-0.5
Arm predicted mass (left)	0.0	0.1	0.2	-0.5	0.1	0.0