[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr14:73,488,591-77,414,761

Best TWAS P=1.15e-12 · Best GWAS P=4.66e-16 conditioned to 1.97e-05

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
8	GTEx	Skin Not Sun Exposed Suprapubic	RPS6KL1	0.08	0.08	enet	11	0.07	1.5e-04	-6.6	-7.1	1.1e-12	0.01	0.05	0.95	TRUE
9	GTEx	Skin Sun Exposed Lower leg	GPATCH2L	0.27	0.18	enet	16	0.23	5.2e-19	6.2	6.8	1.2e-11	0.42	0.99	0.01	TRUE
4	GTEx	Cells Transformed fibroblasts	ELMSAN1	0.15	0.10	lasso	9	0.08	1.1e-06	4.0	5.6	1.6e-08	-0.02	0.26	0.62	TRUE
5	GTEx	Heart Atrial Appendage	LIN52	0.15	0.10	enet	12	0.12	4.3e-06	-3.6	-5.6	1.8e-08	-0.03	0.92	0.01	TRUE
16	The Cancer Genome Atlas	Brain Lower Grade Glioma	C14orf179	0.03	0.03	lasso	2	0.02	2.0e-03	5.3	5.3	1.4e-07	0.32	0.25	0.02	TRUE
1	CommonMind	Brain Pre-frontal Cortex	DLST	0.09	0.11	lasso	2	0.11	4.0e-13	6.8	-6.9	6.4e-12	0.02	0.06	0.94	FALSE
3	GTEx	Cells Transformed fibroblasts	GPATCH2L	0.18	0.16	lasso	2	0.15	3.2e-11	7.3	6.6	3.7e-11	0.37	0.57	0.43	FALSE
6	GTEx	Muscle Skeletal	DLST	0.28	0.26	enet	23	0.26	2.1e-25	6.6	6.5	6.3e-11	0.04	0.09	0.91	FALSE
10	GTEx	Testis	AREL1	0.20	0.14	enet	34	0.13	2.1e-06	-6.3	-6.3	3.0e-10	0.02	0.13	0.87	FALSE
11	METSIM	Adipose	GPATCH2L	0.12	0.12	lasso	7	0.11	3.4e-16	6.2	6.1	1.0e-09	0.39	1.00	0.00	FALSE
14	The Cancer Genome Atlas	Breast Invasive Carcinoma	RPS6KL1	0.03	0.02	lasso	3	0.02	8.5e-06	-6.3	-6.1	1.2e-09	0.01	0.17	0.83	FALSE
15	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RPS6KL1	0.04	0.04	lasso	3	0.03	1.8e-04	-6.3	-5.7	1.3e-08	0.02	0.11	0.82	FALSE
13	The Cancer Genome Atlas	Breast Invasive Carcinoma	C14orf118	0.03	0.02	lasso	6	0.01	6.5e-04	6.4	5.6	2.2e-08	0.72	0.14	0.71	FALSE
7	GTEx	Skin Not Sun Exposed Suprapubic	GPATCH2L	0.24	0.08	lasso	7	0.11	2.1e-06	4.2	5.5	3.0e-08	0.39	0.92	0.02	FALSE
2	GTEx	Adipose Subcutaneous	YLPM1	0.10	0.03	lasso	6	0.02	7.9e-03	5.7	-5.3	1.2e-07	-0.05	0.10	0.36	FALSE
12	METSIM	Adipose	LTBP2	0.07	0.02	enet	17	0.05	1.8e-08	4.9	5.2	1.6e-07	-0.07	0.77	0.23	FALSE