Best TWAS P=1.15e-12 · Best GWAS P=4.66e-16 conditioned to 1.97e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | DLST | 0.09 | 0.11 | lasso | 2 | 0.11 | 4.0e-13 | 6.8 | -6.9 | 6.4e-12 | 0.02 | 0.06 | 0.94 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | YLPM1 | 0.10 | 0.03 | lasso | 6 | 0.02 | 7.9e-03 | 5.7 | -5.3 | 1.2e-07 | -0.05 | 0.10 | 0.36 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | GPATCH2L | 0.18 | 0.16 | lasso | 2 | 0.15 | 3.2e-11 | 7.3 | 6.6 | 3.7e-11 | 0.37 | 0.57 | 0.43 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | ELMSAN1 | 0.15 | 0.10 | lasso | 9 | 0.08 | 1.1e-06 | 4.0 | 5.6 | 1.6e-08 | -0.02 | 0.26 | 0.62 | TRUE |
| 5 | GTEx | Heart Atrial Appendage | LIN52 | 0.15 | 0.10 | enet | 12 | 0.12 | 4.3e-06 | -3.6 | -5.6 | 1.8e-08 | -0.03 | 0.92 | 0.01 | TRUE |
| 6 | GTEx | Muscle Skeletal | DLST | 0.28 | 0.26 | enet | 23 | 0.26 | 2.1e-25 | 6.6 | 6.5 | 6.3e-11 | 0.04 | 0.09 | 0.91 | FALSE |
| 7 | GTEx | Skin Not Sun Exposed Suprapubic | GPATCH2L | 0.24 | 0.08 | lasso | 7 | 0.11 | 2.1e-06 | 4.2 | 5.5 | 3.0e-08 | 0.39 | 0.92 | 0.02 | FALSE |
| 8 | GTEx | Skin Not Sun Exposed Suprapubic | RPS6KL1 | 0.08 | 0.08 | enet | 11 | 0.07 | 1.5e-04 | -6.6 | -7.1 | 1.1e-12 | 0.01 | 0.05 | 0.95 | TRUE |
| 9 | GTEx | Skin Sun Exposed Lower leg | GPATCH2L | 0.27 | 0.18 | enet | 16 | 0.23 | 5.2e-19 | 6.2 | 6.8 | 1.2e-11 | 0.42 | 0.99 | 0.01 | TRUE |
| 10 | GTEx | Testis | AREL1 | 0.20 | 0.14 | enet | 34 | 0.13 | 2.1e-06 | -6.3 | -6.3 | 3.0e-10 | 0.02 | 0.13 | 0.87 | FALSE |
| 11 | METSIM | Adipose | GPATCH2L | 0.12 | 0.12 | lasso | 7 | 0.11 | 3.4e-16 | 6.2 | 6.1 | 1.0e-09 | 0.39 | 1.00 | 0.00 | FALSE |
| 12 | METSIM | Adipose | LTBP2 | 0.07 | 0.02 | enet | 17 | 0.05 | 1.8e-08 | 4.9 | 5.2 | 1.6e-07 | -0.07 | 0.77 | 0.23 | FALSE |
| 13 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C14orf118 | 0.03 | 0.02 | lasso | 6 | 0.01 | 6.5e-04 | 6.4 | 5.6 | 2.2e-08 | 0.72 | 0.14 | 0.71 | FALSE |
| 14 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RPS6KL1 | 0.03 | 0.02 | lasso | 3 | 0.02 | 8.5e-06 | -6.3 | -6.1 | 1.2e-09 | 0.01 | 0.17 | 0.83 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RPS6KL1 | 0.04 | 0.04 | lasso | 3 | 0.03 | 1.8e-04 | -6.3 | -5.7 | 1.3e-08 | 0.02 | 0.11 | 0.82 | FALSE |
| 16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C14orf179 | 0.03 | 0.03 | lasso | 2 | 0.02 | 2.0e-03 | 5.3 | 5.3 | 1.4e-07 | 0.32 | 0.25 | 0.02 | TRUE |