Hub : Genes

LTBP2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0800	0.0390	1.5e-02	-0.001	0.004	0.006	0.011	-0.002	0.3800	1.1e-01	5.2e-02	1.6e-02	9.5e-01
2	METSIM	Adipose	0.0732	0.0268	3.8e-07	0.025	0.038	0.053	0.040	0.048	0.0001	1.8e-06	1.8e-08	1.1e-06	1.0e-07
3	TCGA	Breast Invasive Carcinoma	0.0274	0.0143	8.0e-03	0.001	0.010	0.019	NA	0.001	0.1500	2.7e-03	7.9e-05	NA	1.4e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.1	1.8	3.0	0.7	-1.4	-1.7
Bipolar Disorder or Schizophrenia	0.1	0.3	0.9	0.3	-1.0	-0.1
Depressed Affect (Nagel 2018)	2.5	5.2	9.4	-0.7	-2.4	-3.1
Depression (Nagel 2018)	0.7	1.0	2.7	0.3	-1.6	0.4
Intelligence (Savage-Jansen 2018)	0.4	1.2	2.8	-1.7	0.0	0.9
Neuroticism (Nagel 2018)	2.8	6.6	13.7	-0.0	-3.7	-2.5
Schizophrenia (2018)	0.2	0.5	1.5	-0.2	-0.1	1.2
Schizophrenia vs Biploar Disorder	0.2	0.3	0.6	0.4	0.8	0.2
Worry (Nagel 2018)	3.4	7.1	17.9	0.2	-4.2	-1.8
Alzheimer’s Disease (in mother)	2.3	2.7	4.6	0.5	1.8	2.2
Alzheimer’s Disease (in father)	0.9	1.0	1.4	-0.6	-1.2	-1.1
Alzheimer’s Disease (including proxy)	0.7	1.0	2.9	-0.2	1.7	-0.1
Crohns Disease (2017)	0.3	0.8	1.4	-0.8	-1.2	0.5
Irritable Bowel Disease (IBD)	0.2	0.6	0.9	0.2	-0.9	0.9
Ulcerative Colitis (UC)	0.2	0.5	0.6	0.8	-0.8	0.4
Major Depression (MDD)	2.6	3.2	9.2	-0.5	-3.0	-0.4
Reaction Time	1.0	2.0	2.9	-1.7	-1.6	0.5
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.3	-0.8	0.9	1.1
Breast Cancer	0.1	0.2	0.5	-0.7	-0.0	0.3
Ovarian Cancer	0.8	1.0	2.8	-0.2	-0.4	1.7
Prostate Cancer	0.4	0.6	1.3	0.3	-1.1	0.5
Age at First Birth	2.6	3.7	5.9	2.4	2.2	-0.6
Bipolar Disorder (2011)	0.6	0.6	1.0	0.4	0.8	-1.0
Body Mass Index (BMI) (2010)	1.3	1.8	2.8	-1.7	-1.4	0.8
Coronary Artery Disease (CAD)	0.7	0.9	2.1	0.7	-1.4	-0.3
Crohns Disease (2012)	0.7	1.2	3.1	-1.8	-0.1	-0.5
Mean Putamen Volume	0.4	0.5	1.1	1.1	-0.5	-0.1
Fasting Glucose	0.1	0.1	0.3	0.5	0.3	0.2
HbA1C	0.2	0.2	0.4	0.1	-0.5	0.6
HDL Cholesterol	1.0	1.7	2.8	1.7	1.4	0.5
LDL Cholesterol	0.4	0.7	2.0	0.1	-0.1	-1.4
Lupus	0.5	0.7	1.3	0.3	0.8	-1.2
Neuroticism (2016)	0.8	1.1	2.5	-0.9	-1.6	0.1
Primary Biliary Cirrhosis	1.9	2.7	4.5	1.7	2.1	-0.8
Rheumatoid Arthritis	2.9	4.0	6.9	-2.6	2.2	-0.3
Schizophrenia (2014)	0.1	0.3	0.6	0.8	-0.5	-0.1
Triglycerides	0.6	0.9	1.4	0.3	-1.1	-1.2
Type 2 Diabetes (T2D) (2012)	0.9	1.0	1.5	1.1	-0.4	1.2
Ulcerative Colitis	0.2	0.2	0.6	0.8	-0.1	-0.3
Blood Eosinophil Count	0.3	2.1	3.6	-1.6	1.9	0.4
Blood Platelet Count	0.6	6.6	8.1	-2.1	2.7	2.9
Blood Red Count	0.2	1.8	5.0	-2.2	0.2	-0.5
Blood White Count	0.3	1.9	5.2	0.1	2.3	0.7
Heel T-Score	0.3	2.0	2.3	1.5	-1.4	-1.4
BMI	0.8	4.7	7.7	-2.8	-2.4	0.8
Height	0.3	5.5	12.0	1.9	3.5	-1.0
Waist Hip Ratio (WHR)	0.8	3.7	8.1	-1.5	-2.9	0.9
Systolic Blood Pressure	2.7	13.5	32.5	2.8	-5.7	0.3
Smoking Status	0.4	0.9	1.9	-0.6	-0.7	-1.4
Allergy or Eczema	0.5	1.4	2.3	-0.8	-1.5	1.2
Cardiovascular Disease	1.0	3.4	9.3	-1.0	-3.0	-0.1
Hypothyroidism (self reported)	0.6	1.4	4.1	-0.0	-2.0	-0.3
Respiratory disease	1.5	3.3	7.8	-1.4	-2.8	-0.2
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.1	0.3	-0.2	0.1
Lung FEV1/FVC ratio	2.3	11.7	27.4	2.7	5.2	-0.8
Lung FVC	0.4	1.9	4.8	-0.6	-2.2	0.8
Neuroticism	4.2	10.0	23.3	0.4	-4.8	-2.6
Chronotype (morning person)	2.2	5.1	11.5	1.9	3.4	-0.2
Hair Pigment	0.0	1.1	1.9	-0.2	-1.4	1.1
Tanning	0.2	2.2	5.9	-0.7	2.4	-0.2
Hand grip strength (left)	1.2	3.2	8.9	0.8	-3.0	0.0
Number of treatments/medications taken	2.7	4.8	13.0	-1.1	-3.6	-0.5
Average weekly spirits intake	0.0	0.0	0.1	-0.1	0.3	-0.1
Sensitivity / hurt feelings	1.2	2.0	2.2	1.5	-1.4	-1.3
Frequency of depressed mood in last 2 weeks	0.6	0.8	2.2	0.0	-1.5	-0.5
Hearing difficulty/problems: Yes	1.8	2.7	4.0	-1.4	-2.0	1.5
Relative age of first facial hair	1.0	2.0	2.6	-1.6	1.4	1.2
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	1.4	-1.0	-1.2	-0.9
Ever used hormone-replacement therapy (HRT)	1.0	1.3	3.5	-0.7	-1.9	-0.0
Ever had hysterectomy (womb removed)	0.3	0.4	0.8	0.5	0.3	0.9
Systolic blood pressure, automated reading	2.0	5.9	15.2	1.6	-3.9	-0.0
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	4.0	-2.0	-0.7	0.3
Angina	0.9	1.2	3.5	-0.2	-1.9	0.3
Medication for hormone replacement therapy	3.1	3.4	6.0	2.5	-1.8	-0.9
Vitamin and mineral supplements	2.1	2.8	7.3	2.7	1.0	-0.2
Supplements: Zinc	0.3	0.3	0.8	-0.4	-0.3	-0.9
Medication: Co-codamol	2.0	2.3	2.8	-1.5	-1.7	1.3
Medication: Metformin	0.4	0.6	1.4	-0.5	0.4	1.2
Diabetes (father)	0.5	0.7	1.2	-1.1	-0.5	-0.7
Diabetes (mother)	0.5	0.6	1.6	-0.4	-1.3	0.1
Severe depression (siblings)	1.3	1.5	2.3	1.5	-1.4	-0.5
Pack years adult smoking proportion	1.1	1.7	4.4	-2.1	-0.2	-0.8
Impedance of leg (right)	1.1	5.1	8.7	1.9	-2.9	-1.8
Leg fat-free mass (left)	0.2	1.2	1.8	-0.4	1.3	1.3
Trunk fat percentage	1.3	5.0	12.4	-0.6	-3.5	1.5
Hand grip strength (right)	1.1	2.9	7.0	1.1	-2.6	-0.6
Townsend deprivation index at recruitment	0.7	1.0	2.2	-1.5	-0.6	-0.6
Current tobacco smoking	0.4	0.7	2.0	0.3	0.1	-1.4
Average weekly fortified wine intake	0.5	0.6	1.3	0.6	-1.1	-0.2
Maternal smoking around birth	0.3	0.5	0.8	0.9	-0.5	0.6
Fed-up feelings	2.4	4.4	7.2	-0.6	-2.4	-2.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	3.0	1.2	-1.7	-0.0
Relative age voice broke	0.9	1.3	3.5	-0.6	-0.2	1.9
Taking other prescription medications	3.6	5.6	13.4	-1.7	-3.7	-0.7
Age when periods started (menarche)	0.6	1.5	4.0	-0.7	0.0	-2.0
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	0.3	-0.0	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.1	-0.2	-0.3	0.1
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	3.1	0.5	-0.4	1.8
Qualifications: CSEs or equivalent	0.9	1.2	2.2	0.0	-1.5	1.2
Serious illness, injury or assault to yourself	0.6	0.7	1.8	-1.3	0.0	-0.7
High blood pressure	1.3	3.6	7.3	-1.8	-2.7	0.1
Hayfever, allergic rhinitis or eczema	0.4	0.9	1.6	-1.3	-0.7	0.8
Multivitamins +/- minerals	0.9	1.1	3.3	-1.8	-0.4	0.2
Stomach or abdominal pain in last month	1.3	1.6	2.4	-1.5	-1.4	-0.8
Supplements: Glucosamine	0.3	0.4	0.5	0.7	0.6	0.4
Diverticular disease/diverticulitis (self-reported)	3.6	4.3	10.8	-3.3	-0.1	-1.4
Medication: Atenolol	1.3	1.6	4.2	-0.8	-2.0	-0.2
Medication: Levothyroxine sodium	1.6	2.7	8.0	-0.2	-2.8	-0.2
Sitting height	0.6	4.0	11.3	3.4	-0.6	0.7
Chronic bronchitis/emphysema (father)	2.1	2.4	6.7	-0.7	2.6	-0.3
High blood pressure (mother)	0.2	0.3	0.8	0.0	-0.9	0.3
Body mass index (BMI)	0.4	1.6	2.7	-1.3	-1.6	0.5
Impedance of leg (left)	1.0	4.6	7.9	1.7	-2.8	-1.7
Leg predicted mass (left)	0.3	1.4	2.1	-0.3	1.5	1.4
Trunk fat mass	0.7	2.9	6.9	-0.5	-2.6	1.2
Waist circumference	0.5	1.9	3.8	-1.0	-2.0	0.9
Number of incorrect matches in round	0.6	1.0	1.4	1.1	-0.5	-1.2
Past tobacco smoking	0.6	1.1	3.0	0.0	1.7	0.4
Alcohol usually taken with meals	0.3	0.4	0.6	0.8	0.6	-0.5
Nervous feelings	2.5	4.8	12.6	-0.1	-3.6	-1.3
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	4.4	-1.5	-2.1	-0.4
Hearing difficulty/problems with background noise	1.7	2.7	4.5	-2.1	-1.7	0.9
Hair/balding pattern: Pattern 2	0.7	0.9	2.8	-1.7	-0.0	-0.2
Had menopause	0.3	0.4	0.6	0.8	-0.7	-0.4
Had other major operations	0.7	0.9	2.0	-1.4	0.6	0.5
Forced vital capacity (FVC)	0.2	0.8	1.4	1.2	-0.1	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.7	-0.4	-0.8	-0.4
Ever unenthusiastic/disinterested for a whole week	2.9	3.5	5.0	1.0	-2.2	-2.1
Qualifications: None of the above	0.2	0.3	0.4	-0.5	-0.6	-0.7
Financial difficulties in last 2 years	1.9	2.5	5.2	-2.3	0.4	-1.5
Mouth/teeth dental problems	0.3	0.4	0.9	0.2	1.0	0.6
Heart attack	0.6	0.8	2.1	0.0	0.3	-1.5
Allergy	1.6	3.8	6.3	2.5	1.8	-1.4
Pain all over the body in last month	0.0	0.0	0.1	-0.1	-0.3	0.1
Diabetes (self-reported)	0.1	0.1	0.3	0.2	0.5	0.2
Hayfever/allergic rhinitis (self-reported)	2.2	2.9	7.2	0.9	-0.8	2.7
Medication: Ramipril	0.4	0.6	1.3	0.5	-1.2	0.4
Medication: Simvastatin	0.6	0.9	1.5	-1.0	-0.2	-1.2
Fluid intelligence score	0.8	1.7	4.4	-0.3	0.7	2.1
Illnesses of siblings	0.7	1.0	1.8	-1.0	1.4	0.6
Neuroticism score	4.1	8.5	19.9	0.0	-4.5	-2.4
Weight	0.1	0.4	0.5	-0.5	-0.7	0.7
Impedance of arm (right)	0.4	1.8	3.5	0.7	-1.9	1.2
Arm fat percentage (right)	1.0	4.0	9.1	-1.0	-3.0	1.4
Trunk fat-free mass	0.5	2.8	7.2	0.0	2.7	-1.0
Hip circumference	0.1	0.3	0.7	-0.4	0.0	0.8
Time employed in main current job	0.8	0.9	2.5	0.2	0.4	1.6
Alcohol intake versus 10 years previously	0.4	0.6	0.9	-1.0	-0.8	-0.4
Father’s age at death	2.1	2.8	6.3	-0.5	2.5	-1.4
Worrier / anxious feelings	2.5	4.7	13.7	-0.3	-3.7	-0.6
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	3.5	-1.3	-1.9	0.0
Falls in the last year	2.4	3.2	8.7	-2.9	0.1	0.9
Hair/balding pattern: Pattern 3	0.4	0.6	1.3	0.6	0.0	1.1
Number of live births	0.5	0.8	1.2	-1.1	1.0	-0.1
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	3.4	1.9	0.9	0.7
Pulse rate	0.3	0.5	1.1	0.1	0.5	-1.1
Happiness	4.8	5.9	17.2	0.1	-0.6	-4.1
Noisy workplace	0.6	0.8	1.3	0.8	-0.6	-1.1
Qualifications: A levels/AS levels or equivalent	0.8	1.7	2.1	-1.3	1.5	1.0
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.4	3.9	-2.0	-0.4	-0.5
Mouth/teeth dental problems: Dentures	0.3	0.4	1.3	1.2	-0.0	0.0
Asthma	1.3	2.5	4.1	-1.8	-2.0	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	1.9	-0.6	-1.4	1.1
Medication: Cholesterol lowering	0.2	0.3	0.8	-0.1	-0.2	-0.9
Depression (self-reported)	3.0	3.6	8.0	-0.6	-1.5	-2.8
Medication: Lansoprazole	2.6	3.0	4.9	-1.6	-1.2	-2.2
Prospective memory result	0.8	1.0	2.8	-0.4	0.2	-1.7
Lung cancer (father)	1.8	2.1	4.3	1.3	2.1	0.6
Illnesses of mother	0.2	0.2	0.4	0.5	-0.2	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.1	1.4	0.7	-0.5
Pulse wave Arterial Stiffness index	0.8	0.9	1.6	-1.3	0.1	1.1
Impedance of arm (left)	0.4	1.8	3.2	0.9	-1.2	1.8
Arm fat mass (right)	0.4	1.7	3.5	-0.7	-1.9	1.1
Trunk predicted mass	0.5	2.8	7.5	0.1	2.7	-1.0
Standing height	0.3	2.9	5.6	1.8	2.4	0.2
Length of working week for main job	1.3	1.4	4.2	-0.3	2.0	-0.0
Exposure to tobacco smoke at home	0.6	0.6	1.9	-1.4	0.2	-0.1
Breastfed as a baby	0.2	0.3	0.7	-0.3	0.2	0.8
Tense / ‘highly strung’	4.1	6.7	16.3	0.5	-4.0	-1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	3.9	0.4	-2.0	-0.1
Hair/balding pattern: Pattern 4	0.7	1.8	4.0	0.6	2.0	-1.0
Birth weight of first child	0.1	0.2	0.3	0.3	0.5	-0.4
Peak expiratory flow (PEF)	1.2	2.9	6.7	2.6	0.7	-1.2
Pulse wave reflection index	2.1	2.6	4.2	-2.1	1.9	0.1
Ever highly irritable/argumentative for 2 days	1.0	1.1	1.9	-1.4	-1.2	-0.1
Loud music exposure frequency	0.9	0.9	1.7	0.8	-1.3	-0.7
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.6	0.1	0.8	-0.0
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	1.2	-1.1	-0.8	-0.1
Blood clot in the leg (DVT)	2.8	3.6	9.1	-3.0	-1.0	0.9
Medication: Paracetamol	1.2	2.0	3.4	-0.8	-1.4	1.8
Headache pain in last month	1.0	1.7	3.7	-1.9	-1.2	-0.2
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.4	-0.3	0.4	1.2
Glaucoma (self-reported)	4.4	5.2	13.2	-0.9	-3.6	-1.3
Gout (self-reported)	0.7	0.9	2.7	-0.4	1.6	-0.2
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	4.1	-0.1	-2.0	-0.7
Medication: Amlodipine	0.5	0.8	1.7	1.3	-0.1	-0.7
Medication: Ventolin 100micrograms inhaler	1.7	2.2	5.6	0.9	0.4	-2.4
Birth weight	0.8	1.7	3.7	1.9	1.2	-0.2
Chronic bronchitis/emphysema (mother)	1.3	1.6	2.1	-1.4	1.3	-0.9
High blood pressure (siblings)	0.8	1.2	3.1	1.8	0.6	-0.2
Forced vital capacity (FVC), Best measure	0.0	0.0	0.1	0.3	-0.2	0.0
Body fat percentage	1.3	5.3	14.6	-0.5	-3.8	1.1
Leg fat percentage (right)	1.3	4.6	13.6	-0.1	-3.7	-0.6
Arm fat-free mass (right)	0.2	1.0	2.7	-0.2	1.7	-0.5
Exposure to tobacco smoke outside home	1.8	2.4	4.1	-1.8	-2.0	0.2
Comparative body size at age 10	1.1	3.0	7.2	-0.2	-1.3	2.7
Number of full brothers	0.0	0.1	0.2	0.1	0.4	0.1
Worry too long after embarrassment	0.7	1.3	1.8	1.4	-1.3	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	2.0	2.7	6.2	-1.1	-2.5	-0.8
Wheeze or whistling in the chest in last year	3.6	6.4	10.7	-3.3	-2.9	0.2
Number of children fathered	1.6	1.8	3.1	1.2	-1.0	1.8
Reason for reducing amount of alcohol drunk: Health precaution	1.9	2.2	3.7	1.9	-0.6	-1.6
Age at first live birth	1.1	2.0	4.7	0.2	2.2	-1.1
Pulse wave peak to peak time	1.1	1.3	2.9	1.7	-0.1	-1.0
Health satisfaction	1.7	2.2	4.1	-2.0	-0.8	-1.3
Shortness of breath walking on level ground	0.8	1.0	1.4	-1.1	-1.2	0.6
Qualifications: College or University degree	0.2	0.6	1.4	-0.1	1.2	-0.7
Eye problems/disorders: None of the above	0.1	0.1	0.3	-0.1	-0.4	0.5
Mouth/teeth dental problems: Loose teeth	0.9	1.1	2.8	-0.6	1.7	-0.1
Emphysema/chronic bronchitis	0.5	0.5	0.7	-0.9	0.8	-0.4
Medication for pain relief, constipation, heartburn	2.3	4.0	6.4	2.1	2.5	-1.0
Neck or shoulder pain in last month	1.4	2.0	5.0	-0.7	-2.2	-0.6
Medication: Blood pressure	0.2	0.4	1.1	0.2	-0.2	-1.0
Angina (self-reported)	1.0	1.3	3.6	0.1	-1.9	0.5
Migraine (self-reported)	0.8	1.0	2.3	-1.5	-0.5	-0.8
Medication: Ibuprofen	0.5	0.6	1.2	-0.2	-0.6	1.1
Medication: Allopurinol	0.8	1.1	3.2	-0.2	1.8	0.2
Medication: Omeprazole	0.3	0.4	0.8	-0.9	0.5	-0.0
Medication: Seretide 50 evohaler	1.2	1.4	2.4	-0.0	1.4	-1.6
Mean time to correctly identify matches	0.8	1.5	4.3	-2.1	-0.4	0.3
Heart disease (mother)	0.2	0.2	0.3	-0.5	-0.6	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.6	-0.5	-0.8	1.3
Whole body fat mass	0.7	2.9	7.7	-0.4	-2.8	0.9
Leg fat mass (right)	0.6	2.2	6.3	-0.3	-2.5	0.2
Arm predicted mass (right)	0.2	1.0	2.5	-0.0	1.6	-0.8
Pulse rate, automated reading	0.4	1.2	2.3	0.6	-1.5	0.9
Alcohol intake frequency.	0.9	2.1	3.8	-1.9	-1.3	0.9
Comparative height size at age 10	0.1	0.4	0.7	-0.5	0.4	0.9
Number of full sisters	1.9	2.3	5.9	0.1	1.0	-2.4
Suffer from ‘nerves’	2.7	4.3	8.8	-0.7	-3.0	-1.9
Overall health rating	1.6	3.4	6.4	-1.9	-2.5	0.2
Chest pain or discomfort	1.4	2.1	4.6	-1.1	-2.1	0.5
Had major operations	0.9	1.0	2.3	1.5	0.4	-0.8
Age at last live birth	1.1	1.6	4.7	-0.3	2.2	0.1
Family relationship satisfaction	1.6	2.0	4.2	-0.1	-1.4	-2.0
Leg pain on walking	0.8	1.1	1.7	-1.3	-1.0	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	0.7	0.4	-0.8	0.7
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.7	-0.5	0.0	-0.8
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.8	1.9	0.3	-1.0
Medication: Aspirin	0.8	1.1	1.8	-1.2	-1.4	-0.2
Supplements: Vitamin C	0.6	0.7	1.2	-1.1	0.3	0.9
Knee pain experienced in last month	0.7	1.1	1.2	-1.1	-1.0	1.1
Hypertension (Self-reported)	1.1	3.0	5.7	-1.8	-2.4	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.9	0.1	0.6	-1.4
Illnesses of father: Heart disease	1.8	2.5	6.1	-1.1	0.5	2.5
Illnesses of siblings: Diabetes	2.0	2.5	4.0	1.8	-0.3	-2.0
Smoking status: Previous	0.7	1.1	3.0	0.6	-1.7	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	3.4	1.8	1.3	-0.5
Whole body fat-free mass	0.3	1.7	5.0	-0.2	2.2	-0.1
Leg fat-free mass (right)	0.3	1.7	3.0	-0.5	1.7	1.3
Arm fat percentage (left)	0.9	3.7	7.3	-1.0	-2.7	1.7
Average weekly red wine intake	0.6	0.9	2.3	0.3	1.5	-0.6
Handedness (chirality/laterality): Left-handed	0.7	0.9	1.7	0.8	-0.5	-1.3
Mood swings	2.6	4.6	10.1	-0.0	-3.2	-1.9
Loneliness, isolation	1.1	1.6	2.6	-0.6	-1.3	-1.6
Long-standing illness, disability or infirmity	1.7	2.5	4.1	-1.7	-2.0	-0.7
Ever had bowel cancer screening	0.2	0.2	0.5	0.7	-0.4	-0.2
Diabetes diagnosed by doctor	0.2	0.3	0.5	0.3	-0.5	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	0.5	0.6	-0.5	0.7
Friendships satisfaction	0.9	1.1	2.4	-0.6	-0.8	-1.6
Qualifications: nursing, teaching	1.8	2.8	6.8	-1.2	2.6	0.2
Commuting to job workplace: Walk	2.2	2.4	4.7	0.4	-2.2	1.5
Eye problems/disorders: Cataract	0.7	0.9	2.3	0.3	1.5	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.8	-0.9	-0.1	-0.5
Medication for cholesterol	1.8	2.7	8.0	-0.1	2.8	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.8	2.2	-1.5	0.2	0.1
Back pain experienced in last month	1.6	2.3	6.7	-0.2	-0.6	-2.6
Mineral and other dietary supplements	0.4	0.6	0.9	1.0	-0.4	-0.8
Breast cancer (self-reported)	0.1	0.1	0.3	0.1	0.2	0.5
Asthma (self-reported)	1.5	2.9	4.7	-2.0	-2.2	-0.3
Osteoporosis (self-reported)	0.8	1.0	1.7	-0.1	1.3	1.1
Osteoarthritis (self-reported)	1.3	1.7	4.5	-2.1	-0.0	0.9
Medication: Aspirin	0.8	1.1	1.8	-1.3	-1.2	0.2
Medication: Gliclazide	1.5	1.7	4.8	-0.0	-0.5	2.2
Illnesses of father: None of the above (group 1)	0.8	1.0	2.8	0.2	0.3	-1.7
Smoking status: Current	0.4	0.6	1.7	-0.3	-0.2	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.0	0.4	0.2	-1.0
Whole body water mass	0.3	1.6	4.8	-0.3	2.2	-0.2
Leg predicted mass (right)	0.4	1.9	3.3	-0.5	1.8	1.4
Arm fat mass (left)	0.4	1.7	2.3	-0.9	-1.5	1.4
Number of self-reported non-cancer illnesses	2.5	4.3	6.5	-2.4	-2.5	-0.9
Average weekly champagne plus white wine intake	1.7	2.4	3.5	0.9	1.9	-1.7
Miserableness	1.8	3.1	5.4	0.2	-1.9	-2.3
Guilty feelings	1.8	2.7	7.7	0.4	-2.8	-0.5
Wears glasses or contact lenses	1.6	1.8	4.5	0.0	1.0	-2.1
Ever taken oral contraceptive pill	0.7	0.7	1.7	-0.6	-0.4	-1.3
Hearing aid user	1.4	1.6	3.7	-1.1	0.1	1.9
Mother’s age at death	1.0	1.2	2.4	0.7	1.6	-0.9
Financial situation satisfaction	2.2	2.7	6.1	-0.7	-1.3	-2.5
Tinnitus: Yes, now most or all of the time	2.1	2.4	5.2	-0.9	-1.1	2.3
Commuting to job workplace: Public transport	0.3	0.4	0.7	0.8	0.7	0.1
Eye problems/disorders: Glaucoma	3.2	3.8	9.2	0.1	-3.0	-1.4
Medication: Blood pressure	1.6	3.1	8.3	-0.9	-2.9	0.4
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.0	-1.0	0.6	0.9
Supplements: Fish oil (including cod liver oil)	0.9	1.2	1.6	-1.0	1.3	1.0
High cholesterol (Self-reported)	0.3	0.6	0.9	-1.0	0.1	-0.9
Medication: Bendroflumethiazide	1.2	1.9	4.3	-0.9	-2.1	0.7
Medication: Paracetamol	0.6	1.0	2.2	-0.0	-0.8	1.5
Medication: Lisinopril	1.0	1.3	2.0	1.1	-0.8	-1.4
Medication: Atorvastatin	0.4	0.5	0.9	-0.1	-1.0	0.7
Illnesses of father: High blood pressure	1.1	1.4	2.3	1.1	-1.5	0.8
Alcohol drinker status: Never	0.2	0.2	0.4	-0.0	-0.6	-0.6
Ever smoked	0.1	0.1	0.3	-0.2	-0.3	-0.5
Basal metabolic rate	0.1	0.8	2.1	-0.3	1.5	0.2
Leg fat percentage (left)	1.2	4.2	12.3	-0.4	-3.5	-0.4
Arm fat-free mass (left)	0.1	0.7	1.8	-0.0	1.3	-0.6
Number of operations (self-reported)	0.4	0.6	1.2	-1.1	0.6	-0.4
Average weekly beer plus cider intake	0.7	1.0	1.8	0.5	-1.4	-0.9
Irritability	3.9	6.7	15.9	-1.0	-4.0	-1.8
Risk taking	0.9	1.3	3.3	0.7	1.8	-0.0
Ever had prostate specific antigen (PSA) test	1.6	1.8	3.0	-0.6	1.7	-1.5
Fractured/broken bones in last 5 years	0.5	0.7	0.9	-0.8	-0.7	1.0
Age started oral contraceptive pill	0.8	1.0	1.5	-1.1	-0.4	-1.2
Diastolic blood pressure, automated reading	0.9	2.8	6.5	0.8	-2.5	1.2
Ever depressed for a whole week	0.7	0.9	2.3	-0.0	-1.5	-0.6
Unable to work because of sickness or disability	1.0	1.4	3.6	-1.9	-0.0	-0.7
Commuting to job workplace: Cycle	0.8	0.9	2.3	0.7	0.0	-1.5
Myopia	1.6	2.3	3.8	1.9	1.2	-1.3
Vascular/heart problems diagnosed by doctor	0.9	2.5	4.5	1.7	2.1	-0.3
Cholesterol lowering medication	1.4	2.1	4.5	-2.1	-1.3	0.1
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.8	-1.3	0.6	-0.7
Pain experienced in last month	1.3	2.1	3.4	1.8	1.3	1.1
Supplements: Calcium	1.3	1.5	2.5	-1.2	-1.6	0.8
Basal cell carcinoma (self-reported)	0.2	0.2	0.6	0.1	-0.1	0.8
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.4	-0.1	0.4	-1.2
Deep venous thrombosis (DVT) (self-reported)	2.1	2.7	6.2	-2.5	-0.7	1.3
Heart disease (siblings)	0.6	0.7	1.2	-0.4	-1.1	0.9
Alcohol drinker status: Previous	0.3	0.3	0.8	-0.1	-0.9	0.4
Pack years of smoking	1.3	2.0	5.3	-2.3	-0.2	-0.7
Impedance of whole body	0.6	2.9	5.8	1.7	-2.4	0.4
Leg fat mass (left)	0.5	1.8	5.2	-0.5	-2.3	0.3
Arm predicted mass (left)	0.2	0.8	1.8	-0.4	1.4	-0.6