Hub : Genes

LTBP2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0800 0.0390 1.5e-02 -0.001 0.004 0.006 0.011 -0.002 0.3800 1.1e-01 5.2e-02 1.6e-02 9.5e-01
2 METSIM Adipose 0.0732 0.0268 3.8e-07 0.025 0.038 0.053 0.040 0.048 0.0001 1.8e-06 1.8e-08 1.1e-06 1.0e-07
3 TCGA Breast Invasive Carcinoma 0.0274 0.0143 8.0e-03 0.001 0.010 0.019 NA 0.001 0.1500 2.7e-03 7.9e-05 NA 1.4e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 1.1 1.8 3.0 0.7 -1.4 -1.7
Bipolar Disorder or Schizophrenia 0.1 0.3 0.9 0.3 -1.0 -0.1
Depressed Affect (Nagel 2018) 2.5 5.2 9.4 -0.7 -2.4 -3.1
Depression (Nagel 2018) 0.7 1.0 2.7 0.3 -1.6 0.4
Intelligence (Savage-Jansen 2018) 0.4 1.2 2.8 -1.7 0.0 0.9
Neuroticism (Nagel 2018) 2.8 6.6 13.7 -0.0 -3.7 -2.5
Schizophrenia (2018) 0.2 0.5 1.5 -0.2 -0.1 1.2
Schizophrenia vs Biploar Disorder 0.2 0.3 0.6 0.4 0.8 0.2
Worry (Nagel 2018) 3.4 7.1 17.9 0.2 -4.2 -1.8
Alzheimer’s Disease (in mother) 2.3 2.7 4.6 0.5 1.8 2.2
Alzheimer’s Disease (in father) 0.9 1.0 1.4 -0.6 -1.2 -1.1
Alzheimer’s Disease (including proxy) 0.7 1.0 2.9 -0.2 1.7 -0.1
Crohns Disease (2017) 0.3 0.8 1.4 -0.8 -1.2 0.5
Irritable Bowel Disease (IBD) 0.2 0.6 0.9 0.2 -0.9 0.9
Ulcerative Colitis (UC) 0.2 0.5 0.6 0.8 -0.8 0.4
Major Depression (MDD) 2.6 3.2 9.2 -0.5 -3.0 -0.4
Reaction Time 1.0 2.0 2.9 -1.7 -1.6 0.5
Verbal and Numeric Reasoning (VNR) 0.4 0.9 1.3 -0.8 0.9 1.1
Breast Cancer 0.1 0.2 0.5 -0.7 -0.0 0.3
Ovarian Cancer 0.8 1.0 2.8 -0.2 -0.4 1.7
Prostate Cancer 0.4 0.6 1.3 0.3 -1.1 0.5
Age at First Birth 2.6 3.7 5.9 2.4 2.2 -0.6
Bipolar Disorder (2011) 0.6 0.6 1.0 0.4 0.8 -1.0
Body Mass Index (BMI) (2010) 1.3 1.8 2.8 -1.7 -1.4 0.8
Coronary Artery Disease (CAD) 0.7 0.9 2.1 0.7 -1.4 -0.3
Crohns Disease (2012) 0.7 1.2 3.1 -1.8 -0.1 -0.5
Mean Putamen Volume 0.4 0.5 1.1 1.1 -0.5 -0.1
Fasting Glucose 0.1 0.1 0.3 0.5 0.3 0.2
HbA1C 0.2 0.2 0.4 0.1 -0.5 0.6
HDL Cholesterol 1.0 1.7 2.8 1.7 1.4 0.5
LDL Cholesterol 0.4 0.7 2.0 0.1 -0.1 -1.4
Lupus 0.5 0.7 1.3 0.3 0.8 -1.2
Neuroticism (2016) 0.8 1.1 2.5 -0.9 -1.6 0.1
Primary Biliary Cirrhosis 1.9 2.7 4.5 1.7 2.1 -0.8
Rheumatoid Arthritis 2.9 4.0 6.9 -2.6 2.2 -0.3
Schizophrenia (2014) 0.1 0.3 0.6 0.8 -0.5 -0.1
Triglycerides 0.6 0.9 1.4 0.3 -1.1 -1.2
Type 2 Diabetes (T2D) (2012) 0.9 1.0 1.5 1.1 -0.4 1.2
Ulcerative Colitis 0.2 0.2 0.6 0.8 -0.1 -0.3
Blood Eosinophil Count 0.3 2.1 3.6 -1.6 1.9 0.4
Blood Platelet Count 0.6 6.6 8.1 -2.1 2.7 2.9
Blood Red Count 0.2 1.8 5.0 -2.2 0.2 -0.5
Blood White Count 0.3 1.9 5.2 0.1 2.3 0.7
Heel T-Score 0.3 2.0 2.3 1.5 -1.4 -1.4
BMI 0.8 4.7 7.7 -2.8 -2.4 0.8
Height 0.3 5.5 12.0 1.9 3.5 -1.0
Waist Hip Ratio (WHR) 0.8 3.7 8.1 -1.5 -2.9 0.9
Systolic Blood Pressure 2.7 13.5 32.5 2.8 -5.7 0.3
Smoking Status 0.4 0.9 1.9 -0.6 -0.7 -1.4
Allergy or Eczema 0.5 1.4 2.3 -0.8 -1.5 1.2
Cardiovascular Disease 1.0 3.4 9.3 -1.0 -3.0 -0.1
Hypothyroidism (self reported) 0.6 1.4 4.1 -0.0 -2.0 -0.3
Respiratory disease 1.5 3.3 7.8 -1.4 -2.8 -0.2
Type 2 Diabetes (T2D) (2018) 0.0 0.0 0.1 0.3 -0.2 0.1
Lung FEV1/FVC ratio 2.3 11.7 27.4 2.7 5.2 -0.8
Lung FVC 0.4 1.9 4.8 -0.6 -2.2 0.8
Neuroticism 4.2 10.0 23.3 0.4 -4.8 -2.6
Chronotype (morning person) 2.2 5.1 11.5 1.9 3.4 -0.2
Hair Pigment 0.0 1.1 1.9 -0.2 -1.4 1.1
Tanning 0.2 2.2 5.9 -0.7 2.4 -0.2
Hand grip strength (left) 1.2 3.2 8.9 0.8 -3.0 0.0
Number of treatments/medications taken 2.7 4.8 13.0 -1.1 -3.6 -0.5
Average weekly spirits intake 0.0 0.0 0.1 -0.1 0.3 -0.1
Sensitivity / hurt feelings 1.2 2.0 2.2 1.5 -1.4 -1.3
Frequency of depressed mood in last 2 weeks 0.6 0.8 2.2 0.0 -1.5 -0.5
Hearing difficulty/problems: Yes 1.8 2.7 4.0 -1.4 -2.0 1.5
Relative age of first facial hair 1.0 2.0 2.6 -1.6 1.4 1.2
Other serious medical condition/disability diagnosed by doctor 0.8 1.1 1.4 -1.0 -1.2 -0.9
Ever used hormone-replacement therapy (HRT) 1.0 1.3 3.5 -0.7 -1.9 -0.0
Ever had hysterectomy (womb removed) 0.3 0.4 0.8 0.5 0.3 0.9
Systolic blood pressure, automated reading 2.0 5.9 15.2 1.6 -3.9 -0.0
Eye problems/disorders: Diabetes related eye disease 1.4 1.5 4.0 -2.0 -0.7 0.3
Angina 0.9 1.2 3.5 -0.2 -1.9 0.3
Medication for hormone replacement therapy 3.1 3.4 6.0 2.5 -1.8 -0.9
Vitamin and mineral supplements 2.1 2.8 7.3 2.7 1.0 -0.2
Supplements: Zinc 0.3 0.3 0.8 -0.4 -0.3 -0.9
Medication: Co-codamol 2.0 2.3 2.8 -1.5 -1.7 1.3
Medication: Metformin 0.4 0.6 1.4 -0.5 0.4 1.2
Diabetes (father) 0.5 0.7 1.2 -1.1 -0.5 -0.7
Diabetes (mother) 0.5 0.6 1.6 -0.4 -1.3 0.1
Severe depression (siblings) 1.3 1.5 2.3 1.5 -1.4 -0.5
Pack years adult smoking proportion 1.1 1.7 4.4 -2.1 -0.2 -0.8
Impedance of leg (right) 1.1 5.1 8.7 1.9 -2.9 -1.8
Leg fat-free mass (left) 0.2 1.2 1.8 -0.4 1.3 1.3
Trunk fat percentage 1.3 5.0 12.4 -0.6 -3.5 1.5
Hand grip strength (right) 1.1 2.9 7.0 1.1 -2.6 -0.6
Townsend deprivation index at recruitment 0.7 1.0 2.2 -1.5 -0.6 -0.6
Current tobacco smoking 0.4 0.7 2.0 0.3 0.1 -1.4
Average weekly fortified wine intake 0.5 0.6 1.3 0.6 -1.1 -0.2
Maternal smoking around birth 0.3 0.5 0.8 0.9 -0.5 0.6
Fed-up feelings 2.4 4.4 7.2 -0.6 -2.4 -2.7
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.5 3.0 1.2 -1.7 -0.0
Relative age voice broke 0.9 1.3 3.5 -0.6 -0.2 1.9
Taking other prescription medications 3.6 5.6 13.4 -1.7 -3.7 -0.7
Age when periods started (menarche) 0.6 1.5 4.0 -0.7 0.0 -2.0
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.5 0.3 -0.0 0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.0 0.1 0.1 -0.2 -0.3 0.1
Tinnitus: Yes, but not now, but have in the past 1.1 1.2 3.1 0.5 -0.4 1.8
Qualifications: CSEs or equivalent 0.9 1.2 2.2 0.0 -1.5 1.2
Serious illness, injury or assault to yourself 0.6 0.7 1.8 -1.3 0.0 -0.7
High blood pressure 1.3 3.6 7.3 -1.8 -2.7 0.1
Hayfever, allergic rhinitis or eczema 0.4 0.9 1.6 -1.3 -0.7 0.8
Multivitamins +/- minerals 0.9 1.1 3.3 -1.8 -0.4 0.2
Stomach or abdominal pain in last month 1.3 1.6 2.4 -1.5 -1.4 -0.8
Supplements: Glucosamine 0.3 0.4 0.5 0.7 0.6 0.4
Diverticular disease/diverticulitis (self-reported) 3.6 4.3 10.8 -3.3 -0.1 -1.4
Medication: Atenolol 1.3 1.6 4.2 -0.8 -2.0 -0.2
Medication: Levothyroxine sodium 1.6 2.7 8.0 -0.2 -2.8 -0.2
Sitting height 0.6 4.0 11.3 3.4 -0.6 0.7
Chronic bronchitis/emphysema (father) 2.1 2.4 6.7 -0.7 2.6 -0.3
High blood pressure (mother) 0.2 0.3 0.8 0.0 -0.9 0.3
Body mass index (BMI) 0.4 1.6 2.7 -1.3 -1.6 0.5
Impedance of leg (left) 1.0 4.6 7.9 1.7 -2.8 -1.7
Leg predicted mass (left) 0.3 1.4 2.1 -0.3 1.5 1.4
Trunk fat mass 0.7 2.9 6.9 -0.5 -2.6 1.2
Waist circumference 0.5 1.9 3.8 -1.0 -2.0 0.9
Number of incorrect matches in round 0.6 1.0 1.4 1.1 -0.5 -1.2
Past tobacco smoking 0.6 1.1 3.0 0.0 1.7 0.4
Alcohol usually taken with meals 0.3 0.4 0.6 0.8 0.6 -0.5
Nervous feelings 2.5 4.8 12.6 -0.1 -3.6 -1.3
Frequency of tenseness / restlessness in last 2 weeks 1.5 2.3 4.4 -1.5 -2.1 -0.4
Hearing difficulty/problems with background noise 1.7 2.7 4.5 -2.1 -1.7 0.9
Hair/balding pattern: Pattern 2 0.7 0.9 2.8 -1.7 -0.0 -0.2
Had menopause 0.3 0.4 0.6 0.8 -0.7 -0.4
Had other major operations 0.7 0.9 2.0 -1.4 0.6 0.5
Forced vital capacity (FVC) 0.2 0.8 1.4 1.2 -0.1 1.0
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 0.7 -0.4 -0.8 -0.4
Ever unenthusiastic/disinterested for a whole week 2.9 3.5 5.0 1.0 -2.2 -2.1
Qualifications: None of the above 0.2 0.3 0.4 -0.5 -0.6 -0.7
Financial difficulties in last 2 years 1.9 2.5 5.2 -2.3 0.4 -1.5
Mouth/teeth dental problems 0.3 0.4 0.9 0.2 1.0 0.6
Heart attack 0.6 0.8 2.1 0.0 0.3 -1.5
Allergy 1.6 3.8 6.3 2.5 1.8 -1.4
Pain all over the body in last month 0.0 0.0 0.1 -0.1 -0.3 0.1
Diabetes (self-reported) 0.1 0.1 0.3 0.2 0.5 0.2
Hayfever/allergic rhinitis (self-reported) 2.2 2.9 7.2 0.9 -0.8 2.7
Medication: Ramipril 0.4 0.6 1.3 0.5 -1.2 0.4
Medication: Simvastatin 0.6 0.9 1.5 -1.0 -0.2 -1.2
Fluid intelligence score 0.8 1.7 4.4 -0.3 0.7 2.1
Illnesses of siblings 0.7 1.0 1.8 -1.0 1.4 0.6
Neuroticism score 4.1 8.5 19.9 0.0 -4.5 -2.4
Weight 0.1 0.4 0.5 -0.5 -0.7 0.7
Impedance of arm (right) 0.4 1.8 3.5 0.7 -1.9 1.2
Arm fat percentage (right) 1.0 4.0 9.1 -1.0 -3.0 1.4
Trunk fat-free mass 0.5 2.8 7.2 0.0 2.7 -1.0
Hip circumference 0.1 0.3 0.7 -0.4 0.0 0.8
Time employed in main current job 0.8 0.9 2.5 0.2 0.4 1.6
Alcohol intake versus 10 years previously 0.4 0.6 0.9 -1.0 -0.8 -0.4
Father’s age at death 2.1 2.8 6.3 -0.5 2.5 -1.4
Worrier / anxious feelings 2.5 4.7 13.7 -0.3 -3.7 -0.6
Frequency of tiredness / lethargy in last 2 weeks 1.1 1.7 3.5 -1.3 -1.9 0.0
Falls in the last year 2.4 3.2 8.7 -2.9 0.1 0.9
Hair/balding pattern: Pattern 3 0.4 0.6 1.3 0.6 0.0 1.1
Number of live births 0.5 0.8 1.2 -1.1 1.0 -0.1
Forced expiratory volume in 1-second (FEV1) 0.5 1.6 3.4 1.9 0.9 0.7
Pulse rate 0.3 0.5 1.1 0.1 0.5 -1.1
Happiness 4.8 5.9 17.2 0.1 -0.6 -4.1
Noisy workplace 0.6 0.8 1.3 0.8 -0.6 -1.1
Qualifications: A levels/AS levels or equivalent 0.8 1.7 2.1 -1.3 1.5 1.0
Serious illness, injury or assault of a close relative in last 2 years 1.3 1.4 3.9 -2.0 -0.4 -0.5
Mouth/teeth dental problems: Dentures 0.3 0.4 1.3 1.2 -0.0 0.0
Asthma 1.3 2.5 4.1 -1.8 -2.0 -0.4
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.1 1.9 -0.6 -1.4 1.1
Medication: Cholesterol lowering 0.2 0.3 0.8 -0.1 -0.2 -0.9
Depression (self-reported) 3.0 3.6 8.0 -0.6 -1.5 -2.8
Medication: Lansoprazole 2.6 3.0 4.9 -1.6 -1.2 -2.2
Prospective memory result 0.8 1.0 2.8 -0.4 0.2 -1.7
Lung cancer (father) 1.8 2.1 4.3 1.3 2.1 0.6
Illnesses of mother 0.2 0.2 0.4 0.5 -0.2 -0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.0 2.1 1.4 0.7 -0.5
Pulse wave Arterial Stiffness index 0.8 0.9 1.6 -1.3 0.1 1.1
Impedance of arm (left) 0.4 1.8 3.2 0.9 -1.2 1.8
Arm fat mass (right) 0.4 1.7 3.5 -0.7 -1.9 1.1
Trunk predicted mass 0.5 2.8 7.5 0.1 2.7 -1.0
Standing height 0.3 2.9 5.6 1.8 2.4 0.2
Length of working week for main job 1.3 1.4 4.2 -0.3 2.0 -0.0
Exposure to tobacco smoke at home 0.6 0.6 1.9 -1.4 0.2 -0.1
Breastfed as a baby 0.2 0.3 0.7 -0.3 0.2 0.8
Tense / ‘highly strung’ 4.1 6.7 16.3 0.5 -4.0 -1.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.9 1.4 3.9 0.4 -2.0 -0.1
Hair/balding pattern: Pattern 4 0.7 1.8 4.0 0.6 2.0 -1.0
Birth weight of first child 0.1 0.2 0.3 0.3 0.5 -0.4
Peak expiratory flow (PEF) 1.2 2.9 6.7 2.6 0.7 -1.2
Pulse wave reflection index 2.1 2.6 4.2 -2.1 1.9 0.1
Ever highly irritable/argumentative for 2 days 1.0 1.1 1.9 -1.4 -1.2 -0.1
Loud music exposure frequency 0.9 0.9 1.7 0.8 -1.3 -0.7
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.6 0.1 0.8 -0.0
Mouth/teeth dental problems: Bleeding gums 0.4 0.6 1.2 -1.1 -0.8 -0.1
Blood clot in the leg (DVT) 2.8 3.6 9.1 -3.0 -1.0 0.9
Medication: Paracetamol 1.2 2.0 3.4 -0.8 -1.4 1.8
Headache pain in last month 1.0 1.7 3.7 -1.9 -1.2 -0.2
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 1.4 -0.3 0.4 1.2
Glaucoma (self-reported) 4.4 5.2 13.2 -0.9 -3.6 -1.3
Gout (self-reported) 0.7 0.9 2.7 -0.4 1.6 -0.2
Hypothyroidism/myxoedema (self-reported) 0.8 1.6 4.1 -0.1 -2.0 -0.7
Medication: Amlodipine 0.5 0.8 1.7 1.3 -0.1 -0.7
Medication: Ventolin 100micrograms inhaler 1.7 2.2 5.6 0.9 0.4 -2.4
Birth weight 0.8 1.7 3.7 1.9 1.2 -0.2
Chronic bronchitis/emphysema (mother) 1.3 1.6 2.1 -1.4 1.3 -0.9
High blood pressure (siblings) 0.8 1.2 3.1 1.8 0.6 -0.2
Forced vital capacity (FVC), Best measure 0.0 0.0 0.1 0.3 -0.2 0.0
Body fat percentage 1.3 5.3 14.6 -0.5 -3.8 1.1
Leg fat percentage (right) 1.3 4.6 13.6 -0.1 -3.7 -0.6
Arm fat-free mass (right) 0.2 1.0 2.7 -0.2 1.7 -0.5
Exposure to tobacco smoke outside home 1.8 2.4 4.1 -1.8 -2.0 0.2
Comparative body size at age 10 1.1 3.0 7.2 -0.2 -1.3 2.7
Number of full brothers 0.0 0.1 0.2 0.1 0.4 0.1
Worry too long after embarrassment 0.7 1.3 1.8 1.4 -1.3 0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 2.0 2.7 6.2 -1.1 -2.5 -0.8
Wheeze or whistling in the chest in last year 3.6 6.4 10.7 -3.3 -2.9 0.2
Number of children fathered 1.6 1.8 3.1 1.2 -1.0 1.8
Reason for reducing amount of alcohol drunk: Health precaution 1.9 2.2 3.7 1.9 -0.6 -1.6
Age at first live birth 1.1 2.0 4.7 0.2 2.2 -1.1
Pulse wave peak to peak time 1.1 1.3 2.9 1.7 -0.1 -1.0
Health satisfaction 1.7 2.2 4.1 -2.0 -0.8 -1.3
Shortness of breath walking on level ground 0.8 1.0 1.4 -1.1 -1.2 0.6
Qualifications: College or University degree 0.2 0.6 1.4 -0.1 1.2 -0.7
Eye problems/disorders: None of the above 0.1 0.1 0.3 -0.1 -0.4 0.5
Mouth/teeth dental problems: Loose teeth 0.9 1.1 2.8 -0.6 1.7 -0.1
Emphysema/chronic bronchitis 0.5 0.5 0.7 -0.9 0.8 -0.4
Medication for pain relief, constipation, heartburn 2.3 4.0 6.4 2.1 2.5 -1.0
Neck or shoulder pain in last month 1.4 2.0 5.0 -0.7 -2.2 -0.6
Medication: Blood pressure 0.2 0.4 1.1 0.2 -0.2 -1.0
Angina (self-reported) 1.0 1.3 3.6 0.1 -1.9 0.5
Migraine (self-reported) 0.8 1.0 2.3 -1.5 -0.5 -0.8
Medication: Ibuprofen 0.5 0.6 1.2 -0.2 -0.6 1.1
Medication: Allopurinol 0.8 1.1 3.2 -0.2 1.8 0.2
Medication: Omeprazole 0.3 0.4 0.8 -0.9 0.5 -0.0
Medication: Seretide 50 evohaler 1.2 1.4 2.4 -0.0 1.4 -1.6
Mean time to correctly identify matches 0.8 1.5 4.3 -2.1 -0.4 0.3
Heart disease (mother) 0.2 0.2 0.3 -0.5 -0.6 -0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 1.6 -0.5 -0.8 1.3
Whole body fat mass 0.7 2.9 7.7 -0.4 -2.8 0.9
Leg fat mass (right) 0.6 2.2 6.3 -0.3 -2.5 0.2
Arm predicted mass (right) 0.2 1.0 2.5 -0.0 1.6 -0.8
Pulse rate, automated reading 0.4 1.2 2.3 0.6 -1.5 0.9
Alcohol intake frequency. 0.9 2.1 3.8 -1.9 -1.3 0.9
Comparative height size at age 10 0.1 0.4 0.7 -0.5 0.4 0.9
Number of full sisters 1.9 2.3 5.9 0.1 1.0 -2.4
Suffer from ‘nerves’ 2.7 4.3 8.8 -0.7 -3.0 -1.9
Overall health rating 1.6 3.4 6.4 -1.9 -2.5 0.2
Chest pain or discomfort 1.4 2.1 4.6 -1.1 -2.1 0.5
Had major operations 0.9 1.0 2.3 1.5 0.4 -0.8
Age at last live birth 1.1 1.6 4.7 -0.3 2.2 0.1
Family relationship satisfaction 1.6 2.0 4.2 -0.1 -1.4 -2.0
Leg pain on walking 0.8 1.1 1.7 -1.3 -1.0 0.7
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.4 0.7 0.4 -0.8 0.7
Commuting to job workplace: Car/motor vehicle 0.3 0.3 0.7 -0.5 0.0 -0.8
Illness, injury, bereavement, stress in last 2 years 1.3 1.6 3.8 1.9 0.3 -1.0
Medication: Aspirin 0.8 1.1 1.8 -1.2 -1.4 -0.2
Supplements: Vitamin C 0.6 0.7 1.2 -1.1 0.3 0.9
Knee pain experienced in last month 0.7 1.1 1.2 -1.1 -1.0 1.1
Hypertension (Self-reported) 1.1 3.0 5.7 -1.8 -2.4 0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 1.9 0.1 0.6 -1.4
Illnesses of father: Heart disease 1.8 2.5 6.1 -1.1 0.5 2.5
Illnesses of siblings: Diabetes 2.0 2.5 4.0 1.8 -0.3 -2.0
Smoking status: Previous 0.7 1.1 3.0 0.6 -1.7 0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.8 3.4 1.8 1.3 -0.5
Whole body fat-free mass 0.3 1.7 5.0 -0.2 2.2 -0.1
Leg fat-free mass (right) 0.3 1.7 3.0 -0.5 1.7 1.3
Arm fat percentage (left) 0.9 3.7 7.3 -1.0 -2.7 1.7
Average weekly red wine intake 0.6 0.9 2.3 0.3 1.5 -0.6
Handedness (chirality/laterality): Left-handed 0.7 0.9 1.7 0.8 -0.5 -1.3
Mood swings 2.6 4.6 10.1 -0.0 -3.2 -1.9
Loneliness, isolation 1.1 1.6 2.6 -0.6 -1.3 -1.6
Long-standing illness, disability or infirmity 1.7 2.5 4.1 -1.7 -2.0 -0.7
Ever had bowel cancer screening 0.2 0.2 0.5 0.7 -0.4 -0.2
Diabetes diagnosed by doctor 0.2 0.3 0.5 0.3 -0.5 0.7
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.4 0.5 0.6 -0.5 0.7
Friendships satisfaction 0.9 1.1 2.4 -0.6 -0.8 -1.6
Qualifications: nursing, teaching 1.8 2.8 6.8 -1.2 2.6 0.2
Commuting to job workplace: Walk 2.2 2.4 4.7 0.4 -2.2 1.5
Eye problems/disorders: Cataract 0.7 0.9 2.3 0.3 1.5 -0.4
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.8 -0.9 -0.1 -0.5
Medication for cholesterol 1.8 2.7 8.0 -0.1 2.8 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.8 2.2 -1.5 0.2 0.1
Back pain experienced in last month 1.6 2.3 6.7 -0.2 -0.6 -2.6
Mineral and other dietary supplements 0.4 0.6 0.9 1.0 -0.4 -0.8
Breast cancer (self-reported) 0.1 0.1 0.3 0.1 0.2 0.5
Asthma (self-reported) 1.5 2.9 4.7 -2.0 -2.2 -0.3
Osteoporosis (self-reported) 0.8 1.0 1.7 -0.1 1.3 1.1
Osteoarthritis (self-reported) 1.3 1.7 4.5 -2.1 -0.0 0.9
Medication: Aspirin 0.8 1.1 1.8 -1.3 -1.2 0.2
Medication: Gliclazide 1.5 1.7 4.8 -0.0 -0.5 2.2
Illnesses of father: None of the above (group 1) 0.8 1.0 2.8 0.2 0.3 -1.7
Smoking status: Current 0.4 0.6 1.7 -0.3 -0.2 -1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 1.0 0.4 0.2 -1.0
Whole body water mass 0.3 1.6 4.8 -0.3 2.2 -0.2
Leg predicted mass (right) 0.4 1.9 3.3 -0.5 1.8 1.4
Arm fat mass (left) 0.4 1.7 2.3 -0.9 -1.5 1.4
Number of self-reported non-cancer illnesses 2.5 4.3 6.5 -2.4 -2.5 -0.9
Average weekly champagne plus white wine intake 1.7 2.4 3.5 0.9 1.9 -1.7
Miserableness 1.8 3.1 5.4 0.2 -1.9 -2.3
Guilty feelings 1.8 2.7 7.7 0.4 -2.8 -0.5
Wears glasses or contact lenses 1.6 1.8 4.5 0.0 1.0 -2.1
Ever taken oral contraceptive pill 0.7 0.7 1.7 -0.6 -0.4 -1.3
Hearing aid user 1.4 1.6 3.7 -1.1 0.1 1.9
Mother’s age at death 1.0 1.2 2.4 0.7 1.6 -0.9
Financial situation satisfaction 2.2 2.7 6.1 -0.7 -1.3 -2.5
Tinnitus: Yes, now most or all of the time 2.1 2.4 5.2 -0.9 -1.1 2.3
Commuting to job workplace: Public transport 0.3 0.4 0.7 0.8 0.7 0.1
Eye problems/disorders: Glaucoma 3.2 3.8 9.2 0.1 -3.0 -1.4
Medication: Blood pressure 1.6 3.1 8.3 -0.9 -2.9 0.4
Pain type(s) experienced in last month: Hip pain 0.6 0.7 1.0 -1.0 0.6 0.9
Supplements: Fish oil (including cod liver oil) 0.9 1.2 1.6 -1.0 1.3 1.0
High cholesterol (Self-reported) 0.3 0.6 0.9 -1.0 0.1 -0.9
Medication: Bendroflumethiazide 1.2 1.9 4.3 -0.9 -2.1 0.7
Medication: Paracetamol 0.6 1.0 2.2 -0.0 -0.8 1.5
Medication: Lisinopril 1.0 1.3 2.0 1.1 -0.8 -1.4
Medication: Atorvastatin 0.4 0.5 0.9 -0.1 -1.0 0.7
Illnesses of father: High blood pressure 1.1 1.4 2.3 1.1 -1.5 0.8
Alcohol drinker status: Never 0.2 0.2 0.4 -0.0 -0.6 -0.6
Ever smoked 0.1 0.1 0.3 -0.2 -0.3 -0.5
Basal metabolic rate 0.1 0.8 2.1 -0.3 1.5 0.2
Leg fat percentage (left) 1.2 4.2 12.3 -0.4 -3.5 -0.4
Arm fat-free mass (left) 0.1 0.7 1.8 -0.0 1.3 -0.6
Number of operations (self-reported) 0.4 0.6 1.2 -1.1 0.6 -0.4
Average weekly beer plus cider intake 0.7 1.0 1.8 0.5 -1.4 -0.9
Irritability 3.9 6.7 15.9 -1.0 -4.0 -1.8
Risk taking 0.9 1.3 3.3 0.7 1.8 -0.0
Ever had prostate specific antigen (PSA) test 1.6 1.8 3.0 -0.6 1.7 -1.5
Fractured/broken bones in last 5 years 0.5 0.7 0.9 -0.8 -0.7 1.0
Age started oral contraceptive pill 0.8 1.0 1.5 -1.1 -0.4 -1.2
Diastolic blood pressure, automated reading 0.9 2.8 6.5 0.8 -2.5 1.2
Ever depressed for a whole week 0.7 0.9 2.3 -0.0 -1.5 -0.6
Unable to work because of sickness or disability 1.0 1.4 3.6 -1.9 -0.0 -0.7
Commuting to job workplace: Cycle 0.8 0.9 2.3 0.7 0.0 -1.5
Myopia 1.6 2.3 3.8 1.9 1.2 -1.3
Vascular/heart problems diagnosed by doctor 0.9 2.5 4.5 1.7 2.1 -0.3
Cholesterol lowering medication 1.4 2.1 4.5 -2.1 -1.3 0.1
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 1.8 -1.3 0.6 -0.7
Pain experienced in last month 1.3 2.1 3.4 1.8 1.3 1.1
Supplements: Calcium 1.3 1.5 2.5 -1.2 -1.6 0.8
Basal cell carcinoma (self-reported) 0.2 0.2 0.6 0.1 -0.1 0.8
Heart attack/myocardial infarction (self-reported) 0.4 0.5 1.4 -0.1 0.4 -1.2
Deep venous thrombosis (DVT) (self-reported) 2.1 2.7 6.2 -2.5 -0.7 1.3
Heart disease (siblings) 0.6 0.7 1.2 -0.4 -1.1 0.9
Alcohol drinker status: Previous 0.3 0.3 0.8 -0.1 -0.9 0.4
Pack years of smoking 1.3 2.0 5.3 -2.3 -0.2 -0.7
Impedance of whole body 0.6 2.9 5.8 1.7 -2.4 0.4
Leg fat mass (left) 0.5 1.8 5.2 -0.5 -2.3 0.3
Arm predicted mass (left) 0.2 0.8 1.8 -0.4 1.4 -0.6