Hub : Genes

RASL12

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0600	0.0250	2.9e-04	0.047	0.027	0.045	0.032	0.044	1.9e-06	2.8e-04	3.3e-06	7.9e-05	4.2e-06
2	TCGA	Brain Lower Grade Glioma	0.0656	0.0320	3.1e-06	0.063	0.055	0.051	NA	0.057	1.1e-07	6.7e-07	1.9e-06	NA	4.9e-07
3	TCGA	Prostate Adenocarcinoma	0.0304	0.0188	1.8e-03	0.029	0.022	0.005	NA	0.025	4.4e-04	2.1e-03	8.0e-02	NA	1.1e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.1	0.2	0.5	0.1	-0.1	0.7
Bipolar Disorder or Schizophrenia	0.2	0.4	0.5	-0.7	-0.7	0.6
Depressed Affect (Nagel 2018)	0.1	0.2	0.3	-0.6	0.3	0.1
Depression (Nagel 2018)	0.7	1.0	1.3	-1.1	-1.0	-0.9
Intelligence (Savage-Jansen 2018)	0.4	1.1	1.5	-1.2	-0.7	-1.2
Neuroticism (Nagel 2018)	0.7	1.6	3.7	-1.9	-0.9	-0.5
Schizophrenia (2018)	0.3	0.5	0.9	-1.0	-0.8	0.2
Schizophrenia vs Biploar Disorder	0.2	0.3	0.5	-0.7	-0.6	0.2
Worry (Nagel 2018)	1.6	3.3	6.7	-2.6	-1.8	0.2
Alzheimer’s Disease (in mother)	0.7	0.8	1.6	-1.3	-0.8	-0.4
Alzheimer’s Disease (in father)	5.5	5.9	9.0	-3.0	-2.9	-0.4
Alzheimer’s Disease (including proxy)	1.4	2.0	3.2	-1.8	-1.5	-0.6
Crohns Disease (2017)	1.3	2.8	3.5	-1.9	-1.9	-1.2
Irritable Bowel Disease (IBD)	0.5	1.2	2.1	-1.4	-1.0	-0.6
Ulcerative Colitis (UC)	0.1	0.2	0.3	-0.5	0.3	0.6
Major Depression (MDD)	2.0	2.4	3.5	-1.8	-1.9	-0.7
Reaction Time	0.5	1.0	2.0	1.4	0.9	0.5
Verbal and Numeric Reasoning (VNR)	1.2	2.8	4.7	-1.6	-1.0	-2.2
Breast Cancer	0.1	0.3	0.4	0.5	0.5	0.6
Ovarian Cancer	0.4	0.5	1.4	-0.2	0.3	-1.2
Prostate Cancer	0.7	1.0	1.9	1.4	1.0	0.5
Age at First Birth	0.0	0.1	0.1	0.3	-0.1	-0.4
Bipolar Disorder (2011)	3.3	3.2	3.6	1.9	1.7	1.8
Body Mass Index (BMI) (2010)	0.6	0.9	1.9	1.4	0.9	-0.0
Coronary Artery Disease (CAD)	0.2	0.2	0.4	0.3	-0.6	0.3
Crohns Disease (2012)	0.3	0.5	1.5	-0.1	-0.3	-1.2
Mean Putamen Volume	0.4	0.4	1.3	-0.1	-0.2	-1.1
Fasting Glucose	3.2	3.8	6.7	-2.0	-2.6	-0.8
HbA1C	0.6	0.7	1.9	-0.3	0.1	-1.4
HDL Cholesterol	1.0	1.6	2.5	1.6	1.5	-0.3
LDL Cholesterol	0.2	0.4	1.2	-0.1	0.1	1.1
Lupus	0.1	0.2	0.3	0.1	0.4	0.6
Neuroticism (2016)	0.2	0.3	1.0	-1.0	0.0	-0.2
Primary Biliary Cirrhosis	1.6	2.3	3.3	1.8	1.3	-1.4
Rheumatoid Arthritis	0.9	1.2	1.6	1.2	1.2	0.8
Schizophrenia (2014)	0.1	0.2	0.5	0.0	0.1	0.7
Triglycerides	0.0	0.1	0.1	-0.1	0.3	0.2
Type 2 Diabetes (T2D) (2012)	1.6	1.8	2.2	-1.0	-1.5	-1.4
Ulcerative Colitis	0.2	0.2	0.5	0.3	0.7	0.2
Blood Eosinophil Count	0.3	2.2	2.3	-1.5	-1.5	1.4
Blood Platelet Count	1.0	11.5	17.0	2.1	3.6	4.1
Blood Red Count	0.3	3.0	5.1	0.2	2.2	2.0
Blood White Count	0.5	3.6	4.2	1.6	2.1	1.9
Heel T-Score	0.4	3.2	6.0	2.4	0.1	-1.9
BMI	0.6	3.4	5.7	2.1	2.4	0.2
Height	0.3	5.6	10.5	-3.2	-2.5	0.6
Waist Hip Ratio (WHR)	0.9	3.9	5.1	-2.0	-2.3	-1.6
Systolic Blood Pressure	0.5	2.3	3.0	-1.6	-1.1	1.7
Smoking Status	0.3	0.7	1.3	-1.1	-0.8	0.3
Allergy or Eczema	0.6	1.6	2.4	-1.6	-1.5	-0.3
Cardiovascular Disease	0.2	0.6	1.0	-1.0	-0.1	0.8
Hypothyroidism (self reported)	0.0	0.0	0.1	0.2	-0.1	0.2
Respiratory disease	0.9	2.1	2.4	-1.5	-1.3	1.5
Type 2 Diabetes (T2D) (2018)	0.6	1.2	2.3	0.8	1.5	0.8
Lung FEV1/FVC ratio	2.8	14.1	41.7	0.8	-0.3	-6.5
Lung FVC	0.8	4.3	6.1	2.1	1.5	-2.5
Neuroticism	0.2	0.4	1.2	-1.1	0.0	0.2
Chronotype (morning person)	0.5	1.2	1.8	1.3	1.3	0.4
Hair Pigment	0.0	0.7	1.8	0.4	-0.2	-1.3
Tanning	0.0	0.6	1.4	-1.2	-0.4	0.5
Hand grip strength (left)	1.0	2.6	4.0	-1.8	-2.0	-0.8
Number of treatments/medications taken	0.2	0.4	1.3	-0.1	0.2	1.1
Average weekly spirits intake	0.4	0.5	1.4	0.0	-0.0	-1.2
Sensitivity / hurt feelings	0.2	0.3	0.9	-1.0	-0.3	-0.1
Frequency of depressed mood in last 2 weeks	1.1	1.5	2.7	-1.6	-1.0	-0.9
Hearing difficulty/problems: Yes	0.8	1.2	2.8	-1.7	-0.8	-0.2
Relative age of first facial hair	1.5	3.1	3.9	-1.4	-2.0	-1.9
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.1	-0.0	0.1	-1.1
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.4	0.6	0.5	0.4
Ever had hysterectomy (womb removed)	0.5	0.5	0.8	-0.6	-0.7	-0.9
Systolic blood pressure, automated reading	0.1	0.3	1.0	-0.1	0.0	1.0
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	-0.4	0.2	0.3
Angina	2.1	2.8	4.7	-2.2	-1.5	-1.2
Medication for hormone replacement therapy	0.4	0.5	0.7	-0.3	-0.8	-0.8
Vitamin and mineral supplements	0.1	0.2	0.3	0.3	-0.4	-0.5
Supplements: Zinc	3.2	3.5	5.3	-2.3	-1.7	-1.6
Medication: Co-codamol	0.0	0.0	0.1	-0.1	-0.1	0.2
Medication: Metformin	0.8	1.1	1.4	0.8	1.2	1.2
Diabetes (father)	2.4	3.0	6.3	1.2	1.1	2.5
Diabetes (mother)	3.9	5.0	10.8	1.4	1.5	3.3
Severe depression (siblings)	3.7	4.1	6.6	-2.3	-2.6	-0.8
Pack years adult smoking proportion	0.4	0.6	1.2	-1.1	-0.8	-0.1
Impedance of leg (right)	0.4	2.1	3.0	-1.7	-1.7	0.6
Leg fat-free mass (left)	0.1	0.3	0.9	0.0	0.2	-0.9
Trunk fat percentage	0.2	0.6	1.0	-1.0	-0.7	0.6
Hand grip strength (right)	1.1	3.0	4.2	-2.0	-2.0	-1.0
Townsend deprivation index at recruitment	0.7	1.0	1.6	-1.3	-1.0	0.7
Current tobacco smoking	0.1	0.2	0.4	0.3	0.4	0.6
Average weekly fortified wine intake	0.1	0.1	0.2	0.5	0.0	-0.5
Maternal smoking around birth	0.8	1.2	2.1	-1.4	-1.2	-0.1
Fed-up feelings	0.5	0.9	2.2	-1.5	-0.8	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.5	-0.4	-0.1	-0.7
Relative age voice broke	2.3	3.5	5.7	-1.2	-1.8	-2.4
Taking other prescription medications	0.0	0.0	0.1	-0.1	-0.1	0.3
Age when periods started (menarche)	0.6	1.6	4.0	-0.1	-0.8	-2.0
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.4	0.6	0.0	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	2.9	1.7	0.5	-1.2
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.7	0.1	-0.2	0.8
Qualifications: CSEs or equivalent	1.0	1.3	3.2	-0.6	-0.5	1.8
Serious illness, injury or assault to yourself	0.0	0.0	0.1	0.3	0.2	-0.2
High blood pressure	1.3	3.5	8.7	-1.4	-0.2	3.0
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.3	-1.1	-1.0	-0.4
Multivitamins +/- minerals	0.0	0.0	0.1	0.1	0.3	-0.1
Stomach or abdominal pain in last month	1.3	1.6	2.5	-1.6	-1.5	0.2
Supplements: Glucosamine	3.3	4.3	5.6	2.4	2.3	1.3
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.1	-0.4	0.3	0.3
Medication: Atenolol	0.7	0.9	1.1	-1.0	-1.0	0.8
Medication: Levothyroxine sodium	0.0	0.0	0.0	-0.1	-0.2	-0.0
Sitting height	0.4	2.7	4.3	-2.1	-1.7	-0.9
Chronic bronchitis/emphysema (father)	0.8	1.0	1.5	1.2	1.2	-0.1
High blood pressure (mother)	0.5	0.7	1.3	0.2	0.8	1.1
Body mass index (BMI)	0.3	1.1	2.0	1.1	1.4	0.3
Impedance of leg (left)	1.0	5.0	7.2	-2.7	-2.7	0.8
Leg predicted mass (left)	0.1	0.3	1.0	-0.0	0.2	-1.0
Trunk fat mass	0.1	0.3	0.6	-0.8	-0.5	0.1
Waist circumference	0.0	0.0	0.1	-0.1	0.3	0.1
Number of incorrect matches in round	0.1	0.2	0.5	-0.1	-0.1	-0.7
Past tobacco smoking	0.9	1.6	2.8	1.7	1.2	-0.7
Alcohol usually taken with meals	0.0	0.0	0.1	0.4	0.0	0.0
Nervous feelings	0.7	1.2	2.1	-1.5	-0.8	-0.9
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.4	3.4	-1.8	-1.0	1.7
Hearing difficulty/problems with background noise	0.1	0.2	0.4	-0.7	0.1	0.4
Hair/balding pattern: Pattern 2	1.1	1.4	2.7	-1.2	-1.6	-0.1
Had menopause	0.2	0.3	0.4	-0.3	-0.7	-0.6
Had other major operations	0.1	0.1	0.3	0.2	0.6	0.1
Forced vital capacity (FVC)	0.1	0.3	0.8	0.2	0.1	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	2.1	1.1	-0.0	-1.4
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.6	-1.3	-1.0	-0.1
Qualifications: None of the above	0.2	0.4	0.6	0.8	0.6	-0.6
Financial difficulties in last 2 years	1.4	1.9	3.8	0.5	1.3	2.0
Mouth/teeth dental problems	0.1	0.2	0.3	0.3	-0.5	0.4
Heart attack	0.6	0.8	1.5	-1.2	-0.8	0.0
Allergy	0.7	1.7	2.8	1.7	1.4	-0.6
Pain all over the body in last month	1.3	1.4	2.5	-1.2	-0.6	1.6
Diabetes (self-reported)	0.2	0.3	0.7	-0.6	0.1	0.8
Hayfever/allergic rhinitis (self-reported)	0.3	0.3	0.7	-0.0	-0.5	-0.9
Medication: Ramipril	0.0	0.0	0.1	-0.3	0.1	0.1
Medication: Simvastatin	0.2	0.3	0.4	0.0	0.6	-0.6
Fluid intelligence score	0.5	1.1	2.0	-1.4	-0.9	-0.7
Illnesses of siblings	2.7	3.8	10.8	-0.0	-0.8	-3.3
Neuroticism score	0.3	0.7	1.4	-1.2	-0.0	0.7
Weight	0.0	0.0	0.0	-0.2	0.2	-0.0
Impedance of arm (right)	0.7	3.0	4.3	-1.9	-2.1	-1.0
Arm fat percentage (right)	0.0	0.2	0.4	0.3	0.6	-0.3
Trunk fat-free mass	0.1	0.4	1.1	-0.2	0.1	-1.0
Hip circumference	0.2	0.7	1.2	0.7	1.1	0.5
Time employed in main current job	0.6	0.6	1.5	0.5	0.4	1.2
Alcohol intake versus 10 years previously	0.2	0.4	0.9	-0.4	-0.1	-1.0
Father’s age at death	1.1	1.5	4.1	0.3	0.5	-2.0
Worrier / anxious feelings	0.4	0.7	1.8	-1.4	-0.6	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.9	-1.4	-0.6	-0.2
Falls in the last year	0.1	0.1	0.4	-0.6	0.1	-0.1
Hair/balding pattern: Pattern 3	0.9	1.4	2.1	1.1	1.5	0.9
Number of live births	1.0	1.4	1.9	0.9	1.2	1.4
Forced expiratory volume in 1-second (FEV1)	0.9	3.1	9.2	0.2	-0.2	-3.0
Pulse rate	2.0	3.3	4.3	1.3	2.1	2.0
Happiness	0.4	0.4	0.8	-0.9	-0.4	0.6
Noisy workplace	1.1	1.4	2.9	-1.7	-1.1	0.4
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.7	-0.9	-0.3	-1.3
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.7	-0.9	-0.6	-0.2
Mouth/teeth dental problems: Dentures	0.1	0.1	0.2	0.0	0.4	-0.5
Asthma	0.4	0.8	2.1	-0.2	-0.4	1.4
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.6	0.1	0.8	0.2
Medication: Cholesterol lowering	0.1	0.1	0.2	-0.0	0.3	0.5
Depression (self-reported)	2.2	2.6	3.2	-1.6	-1.4	-1.8
Medication: Lansoprazole	2.8	3.2	4.8	-2.0	-2.2	-0.9
Prospective memory result	0.2	0.2	0.4	-0.2	-0.6	0.4
Lung cancer (father)	1.4	1.6	2.0	-1.0	-1.4	-1.4
Illnesses of mother	0.2	0.2	0.6	-0.1	-0.1	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.4	9.7	-0.2	-0.6	-3.1
Pulse wave Arterial Stiffness index	1.6	1.9	2.8	-1.7	-1.6	0.3
Impedance of arm (left)	0.8	3.5	5.4	-2.2	-2.3	-0.3
Arm fat mass (right)	0.0	0.1	0.1	0.0	0.4	-0.3
Trunk predicted mass	0.1	0.4	1.0	-0.1	0.2	-1.0
Standing height	0.6	5.5	9.0	-3.0	-2.6	-0.8
Length of working week for main job	0.5	0.6	1.1	0.4	0.7	1.0
Exposure to tobacco smoke at home	0.3	0.3	0.6	-0.4	-0.3	-0.8
Breastfed as a baby	0.0	0.0	0.0	0.0	-0.0	0.1
Tense / ‘highly strung’	2.2	3.7	6.1	-2.0	-1.0	2.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	2.0	-1.4	-1.0	-0.1
Hair/balding pattern: Pattern 4	1.4	3.3	4.6	1.7	1.6	2.1
Birth weight of first child	1.3	2.3	3.0	-1.6	-1.7	-1.2
Peak expiratory flow (PEF)	0.3	0.7	1.9	-0.1	-0.6	-1.4
Pulse wave reflection index	2.4	3.0	5.3	-1.8	-2.3	-0.7
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.7	0.1	-0.0	-0.8
Loud music exposure frequency	1.7	1.9	3.5	-1.9	-1.3	0.6
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.4	0.1	0.3	1.5
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.9	-0.1	0.1	-0.9
Blood clot in the leg (DVT)	0.3	0.4	0.7	0.9	0.1	-0.7
Medication: Paracetamol	0.7	1.2	3.4	-0.1	0.4	1.9
Headache pain in last month	0.3	0.5	1.0	-1.0	-0.5	-0.4
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.4	0.2	-0.3	-0.6
Glaucoma (self-reported)	4.1	4.9	5.3	2.2	2.1	2.3
Gout (self-reported)	1.0	1.4	2.7	-0.8	-1.0	-1.6
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.2	-0.1	-0.4	-0.2
Medication: Amlodipine	0.6	0.8	1.6	-1.3	-0.7	-0.5
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.4	-0.2	0.1	1.6
Birth weight	1.3	2.8	4.1	-1.3	-2.0	-1.6
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.1	-1.1	-0.8	-0.4
High blood pressure (siblings)	2.1	3.0	5.0	-1.6	-1.1	2.2
Forced vital capacity (FVC), Best measure	0.2	0.6	1.3	-0.5	-0.6	-1.1
Body fat percentage	0.0	0.2	0.5	-0.3	-0.0	0.7
Leg fat percentage (right)	0.1	0.3	0.5	0.4	0.7	0.3
Arm fat-free mass (right)	0.0	0.1	0.1	-0.3	-0.1	-0.2
Exposure to tobacco smoke outside home	0.6	0.8	2.3	-0.2	0.4	1.5
Comparative body size at age 10	0.6	1.7	3.3	1.0	0.8	-1.8
Number of full brothers	1.3	1.7	3.1	-1.8	-1.2	-0.6
Worry too long after embarrassment	0.2	0.3	0.8	0.4	0.9	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.5	2.4	-0.9	-1.2	-1.5
Wheeze or whistling in the chest in last year	1.9	3.3	7.5	-1.4	-0.8	2.7
Number of children fathered	1.1	1.3	1.6	1.3	1.1	1.0
Reason for reducing amount of alcohol drunk: Health precaution	2.5	2.9	3.1	1.8	1.8	1.6
Age at first live birth	1.0	1.7	2.9	-1.1	-1.1	-1.7
Pulse wave peak to peak time	1.6	1.9	3.0	1.7	1.7	-0.3
Health satisfaction	0.3	0.3	0.9	0.3	0.2	-0.9
Shortness of breath walking on level ground	0.5	0.7	1.9	0.1	0.2	-1.4
Qualifications: College or University degree	0.1	0.3	0.5	0.6	0.7	-0.3
Eye problems/disorders: None of the above	1.8	2.1	3.8	-1.3	-0.9	-1.9
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.2	0.6	1.1	0.3
Emphysema/chronic bronchitis	3.1	3.5	6.4	-2.5	-2.0	0.5
Medication for pain relief, constipation, heartburn	0.5	0.9	2.3	0.6	-0.3	-1.5
Neck or shoulder pain in last month	0.8	1.2	1.6	0.8	1.3	1.2
Medication: Blood pressure	0.2	0.3	0.4	-0.7	-0.4	0.6
Angina (self-reported)	1.7	2.2	3.2	-1.8	-1.2	-1.4
Migraine (self-reported)	0.1	0.1	0.3	-0.1	-0.1	-0.6
Medication: Ibuprofen	0.2	0.2	0.5	0.4	0.7	-0.3
Medication: Allopurinol	1.3	1.8	2.7	-1.1	-1.2	-1.6
Medication: Omeprazole	0.2	0.3	0.4	-0.5	-0.5	0.7
Medication: Seretide 50 evohaler	3.7	4.3	6.8	-2.6	-2.3	0.8
Mean time to correctly identify matches	0.1	0.3	0.5	0.7	0.5	0.1
Heart disease (mother)	0.1	0.1	0.1	-0.2	-0.3	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.2	1.1	0.9	0.4
Whole body fat mass	0.0	0.1	0.2	-0.4	0.1	0.4
Leg fat mass (right)	0.0	0.2	0.4	0.3	0.6	0.0
Arm predicted mass (right)	0.0	0.2	0.2	-0.4	-0.3	-0.5
Pulse rate, automated reading	0.4	1.4	2.4	1.4	1.6	0.2
Alcohol intake frequency.	0.4	1.0	2.8	0.2	0.1	-1.7
Comparative height size at age 10	0.1	0.7	1.3	-1.1	-0.8	0.4
Number of full sisters	0.1	0.1	0.2	-0.2	-0.1	0.4
Suffer from ‘nerves’	0.9	1.5	2.3	-1.5	-1.4	-0.5
Overall health rating	1.4	2.9	4.8	-2.2	-1.9	0.6
Chest pain or discomfort	4.6	6.6	11.8	-3.4	-2.8	0.5
Had major operations	2.1	2.4	4.1	-2.0	-1.4	1.1
Age at last live birth	1.6	2.3	3.0	-1.5	-1.7	-1.3
Family relationship satisfaction	1.0	1.3	2.8	0.8	1.7	0.6
Leg pain on walking	1.2	1.6	2.8	1.4	1.7	0.2
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	2.5	-1.3	-1.6	0.2
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.6	-0.9	-1.3	0.1
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.6	-1.0	-1.3	-0.6
Medication: Aspirin	0.1	0.1	0.2	-0.4	0.4	0.3
Supplements: Vitamin C	0.2	0.2	0.4	-0.6	-0.3	-0.5
Knee pain experienced in last month	0.8	1.2	2.5	0.5	0.9	1.6
Hypertension (Self-reported)	0.9	2.4	5.3	-1.4	-0.3	2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	0.8	-0.7	-0.9	0.0
Illnesses of father: Heart disease	0.0	0.0	0.1	-0.2	-0.3	0.1
Illnesses of siblings: Diabetes	0.9	1.1	2.9	-0.2	0.5	1.7
Smoking status: Previous	2.5	3.7	6.3	-2.5	-1.9	1.2
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.8	4.2	-2.0	-2.0	-0.4
Whole body fat-free mass	0.1	0.3	0.9	-0.3	-0.1	-1.0
Leg fat-free mass (right)	0.1	0.5	1.1	-0.4	-0.3	-1.1
Arm fat percentage (left)	0.0	0.2	0.3	0.3	0.6	-0.2
Average weekly red wine intake	0.1	0.1	0.2	-0.5	-0.0	0.1
Handedness (chirality/laterality): Left-handed	0.5	0.5	1.6	-0.1	0.2	-1.3
Mood swings	0.1	0.1	0.2	-0.5	0.4	0.2
Loneliness, isolation	0.2	0.3	0.7	0.2	0.9	0.4
Long-standing illness, disability or infirmity	0.1	0.1	0.3	-0.5	-0.2	0.2
Ever had bowel cancer screening	0.1	0.1	0.2	-0.4	0.5	-0.1
Diabetes diagnosed by doctor	0.9	1.5	3.0	0.4	1.2	1.7
Ever had stillbirth, spontaneous miscarriage or termination	3.6	3.8	5.2	-1.8	-1.7	2.3
Friendships satisfaction	0.8	1.0	1.9	1.0	1.4	-0.1
Qualifications: nursing, teaching	0.4	0.7	1.0	0.3	1.0	-1.0
Commuting to job workplace: Walk	2.0	2.2	6.5	-0.2	-0.1	-2.6
Eye problems/disorders: Cataract	0.4	0.4	1.0	-0.3	-0.4	1.0
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.5	-0.3	0.7	0.7
Medication for cholesterol	0.4	0.7	1.3	1.2	0.8	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.4	0.3	0.6	-0.0
Back pain experienced in last month	2.0	3.0	5.4	-2.3	-1.9	0.1
Mineral and other dietary supplements	0.7	1.0	1.9	-0.7	-1.4	-0.8
Breast cancer (self-reported)	0.3	0.4	1.0	1.0	0.5	-0.2
Asthma (self-reported)	0.6	1.1	2.9	-0.4	-0.5	1.7
Osteoporosis (self-reported)	0.6	0.7	1.1	-1.1	-1.0	-0.1
Osteoarthritis (self-reported)	3.3	4.3	6.1	2.1	2.5	1.6
Medication: Aspirin	0.2	0.2	0.6	-0.8	0.0	0.3
Medication: Gliclazide	0.8	0.9	1.0	1.0	0.9	0.9
Illnesses of father: None of the above (group 1)	1.2	1.4	2.5	-0.9	-1.0	-1.6
Smoking status: Current	0.2	0.4	0.5	0.7	0.7	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.9	4.1	11.0	1.1	0.2	-3.3
Whole body water mass	0.1	0.3	0.9	-0.2	0.0	-1.0
Leg predicted mass (right)	0.1	0.4	0.9	-0.4	-0.3	-1.0
Arm fat mass (left)	0.0	0.1	0.3	0.2	0.6	-0.3
Number of self-reported non-cancer illnesses	0.5	0.9	1.2	-1.1	-0.6	1.0
Average weekly champagne plus white wine intake	0.1	0.1	0.3	-0.1	0.3	0.5
Miserableness	0.4	0.7	2.0	-1.4	-0.2	-0.1
Guilty feelings	1.1	1.6	3.2	-1.8	-0.9	-0.8
Wears glasses or contact lenses	1.4	1.6	2.8	-1.3	-1.7	-0.4
Ever taken oral contraceptive pill	0.5	0.5	0.7	-0.3	-0.8	-0.9
Hearing aid user	0.1	0.1	0.2	-0.4	0.0	0.3
Mother’s age at death	0.4	0.5	0.7	0.6	0.6	0.8
Financial situation satisfaction	0.0	0.0	0.1	0.0	0.4	-0.0
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.0	0.1	-0.1	-1.0
Commuting to job workplace: Public transport	1.2	1.4	2.0	1.2	1.4	-0.9
Eye problems/disorders: Glaucoma	2.7	3.2	4.4	2.1	1.9	1.2
Medication: Blood pressure	1.0	1.8	2.8	-1.4	-0.8	1.7
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.4	-0.2	0.3	0.6
Supplements: Fish oil (including cod liver oil)	2.2	2.8	3.8	1.3	1.9	1.8
High cholesterol (Self-reported)	0.1	0.2	0.6	0.1	0.3	-0.8
Medication: Bendroflumethiazide	0.7	1.0	1.3	0.7	1.1	1.2
Medication: Paracetamol	0.8	1.3	2.9	0.3	0.9	1.7
Medication: Lisinopril	0.6	0.7	1.5	-0.7	-0.5	1.2
Medication: Atorvastatin	1.5	1.8	2.8	-1.4	-1.7	0.8
Illnesses of father: High blood pressure	2.3	2.8	8.0	-0.1	0.6	2.8
Alcohol drinker status: Never	0.2	0.3	0.5	0.3	0.7	0.5
Ever smoked	0.4	0.6	0.9	-0.9	-1.0	0.5
Basal metabolic rate	0.0	0.2	0.6	-0.2	0.1	-0.8
Leg fat percentage (left)	0.0	0.0	0.0	-0.1	0.1	0.2
Arm fat-free mass (left)	0.0	0.0	0.0	-0.2	0.2	-0.1
Number of operations (self-reported)	1.4	2.1	3.6	-1.9	-1.4	0.8
Average weekly beer plus cider intake	0.1	0.2	0.3	-0.5	-0.5	-0.2
Irritability	0.4	0.6	1.8	-1.3	-0.2	0.2
Risk taking	0.1	0.1	0.1	-0.3	-0.4	0.0
Ever had prostate specific antigen (PSA) test	2.9	3.3	4.8	1.9	2.2	1.2
Fractured/broken bones in last 5 years	1.9	2.4	3.6	-1.9	-1.9	-0.1
Age started oral contraceptive pill	0.3	0.4	0.6	0.6	0.3	-0.8
Diastolic blood pressure, automated reading	1.1	3.5	10.2	-0.2	0.5	3.2
Ever depressed for a whole week	0.5	0.6	0.8	-0.9	-0.8	-0.4
Unable to work because of sickness or disability	2.2	2.8	5.0	-2.2	-1.8	0.2
Commuting to job workplace: Cycle	1.1	1.3	1.7	1.1	1.3	-1.0
Myopia	0.1	0.1	0.3	0.2	0.5	-0.1
Vascular/heart problems diagnosed by doctor	0.9	2.6	3.8	1.8	0.8	-1.9
Cholesterol lowering medication	0.3	0.5	1.3	0.2	1.2	0.1
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.6	-0.5	-0.5	0.8
Pain experienced in last month	0.1	0.2	0.4	0.3	0.2	-0.6
Supplements: Calcium	0.1	0.2	0.3	-0.4	-0.5	0.2
Basal cell carcinoma (self-reported)	0.5	0.6	1.2	1.1	0.3	-0.7
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.5	-1.2	-0.8	0.0
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.3	0.5	-0.1	-0.5
Heart disease (siblings)	1.4	1.7	2.6	1.0	1.2	1.6
Alcohol drinker status: Previous	0.2	0.2	0.5	-0.2	-0.1	-0.7
Pack years of smoking	0.2	0.2	0.5	-0.7	-0.4	-0.1
Impedance of whole body	0.9	4.6	6.9	-2.6	-2.6	0.5
Leg fat mass (left)	0.0	0.0	0.1	-0.0	0.3	-0.1
Arm predicted mass (left)	0.0	0.1	0.3	-0.3	0.0	-0.6