[Hub]/) : Traits : Lung FEV1/FVC ratio : ←

chr22:40,472,399-43,615,241

Best TWAS P=1.6e-13 · Best GWAS P=1.48e-12 conditioned to 0.0554

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
2	CommonMind	Brain Pre-frontal Cortex	EP300	0.05	0.00	bslmm	289	0.02	3.2e-03	5.1	-7.4	1.6e-13	0.36	0.16	0.66	TRUE
19	The Cancer Genome Atlas	Colon Adenocarcinoma	MKL1	0.05	0.03	blup	105	0.04	3.9e-03	-6.5	-5.6	2.3e-08	0.51	0.04	0.26	TRUE
8	GTEx	Colon Sigmoid	RRP7A	0.34	0.04	enet	26	0.13	1.9e-05	4.2	5.2	1.6e-07	-0.01	0.04	0.16	TRUE
15	GTEx	Skin Sun Exposed Lower leg	L3MBTL2	0.08	0.03	enet	16	0.06	2.1e-05	-6.5	7.3	3.9e-13	-0.35	0.02	0.97	FALSE
9	GTEx	Esophagus Gastroesophageal Junction	RP4-756G23.5	0.12	0.10	lasso	4	0.08	7.7e-04	-6.8	7.2	7.9e-13	-0.26	0.02	0.96	FALSE
18	The Cancer Genome Atlas	Breast Invasive Carcinoma	EP300	0.01	0.00	blup	51	0.01	1.8e-02	-6.6	-6.8	1.0e-11	0.27	0.01	0.82	FALSE
6	GTEx	Cells EBV-transformed lymphocytes	RP4-756G23.5	0.12	0.10	enet	11	0.09	5.3e-04	-6.6	6.7	1.8e-11	-0.26	0.06	0.82	FALSE
4	GTEx	Brain Cortex	RP4-756G23.5	0.10	0.12	lasso	7	0.08	2.8e-03	-6.6	6.6	4.6e-11	-0.26	0.06	0.74	FALSE
11	GTEx	Heart Left Ventricle	RP4-756G23.5	0.09	0.08	lasso	6	0.07	9.5e-05	-6.6	6.6	5.5e-11	-0.26	0.07	0.92	FALSE
16	GTEx	Skin Sun Exposed Lower leg	RP4-756G23.5	0.05	0.07	lasso	6	0.05	6.9e-05	-6.6	6.6	5.5e-11	-0.26	0.07	0.92	FALSE
10	GTEx	Esophagus Mucosa	RP4-756G23.5	0.10	0.09	lasso	5	0.09	1.9e-06	-6.6	6.5	1.1e-10	-0.23	0.06	0.94	FALSE
7	GTEx	Cells Transformed fibroblasts	RP4-756G23.5	0.07	0.06	enet	8	0.03	2.7e-03	-6.6	6.4	1.7e-10	-0.22	0.07	0.92	FALSE
12	GTEx	Liver	L3MBTL2	0.13	0.08	lasso	7	0.09	1.3e-03	-6.6	6.3	2.5e-10	-0.20	0.06	0.61	FALSE
13	GTEx	Pituitary	L3MBTL2	0.19	0.15	enet	17	0.19	1.6e-05	-6.8	6.3	2.7e-10	-0.22	0.02	0.94	FALSE
5	GTEx	Brain Frontal Cortex BA9	SLC25A17	0.11	-0.01	lasso	5	0.00	3.5e-01	-3.5	-6.3	3.1e-10	0.66	0.06	0.40	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CHADL	0.08	0.06	lasso	8	0.05	2.8e-07	-6.6	6.2	6.2e-10	-0.23	0.07	0.93	FALSE
21	The Cancer Genome Atlas	Stomach Adenocarcinoma	MKL1	0.05	0.01	blup	95	0.02	2.2e-02	3.6	-5.9	2.8e-09	0.64	0.11	0.25	FALSE
14	GTEx	Skin Not Sun Exposed Suprapubic	L3MBTL2	0.08	0.00	lasso	4	0.02	2.2e-02	-6.6	5.8	8.3e-09	-0.39	0.05	0.54	FALSE
17	GTEx	Thyroid	ZC3H7B	0.11	0.07	enet	7	0.07	3.9e-06	5.5	5.7	1.1e-08	-0.18	0.26	0.43	FALSE
3	GTEx	Artery Tibial	L3MBTL2	0.05	0.06	lasso	3	0.05	1.0e-04	5.1	-5.4	6.9e-08	0.20	0.42	0.15	FALSE
20	The Cancer Genome Atlas	Lung Adenocarcinoma	ADSL	0.03	0.00	blup	33	0.01	8.9e-03	-3.9	-5.2	2.6e-07	0.52	0.00	0.05	FALSE