Best TWAS P=2.42e-36 · Best GWAS P=5.12e-96 conditioned to 1.04e-16
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 8 | ROSMAP | Brain Pre-frontal Cortex | TIGD2 | 0.06 | 0.01 | blup | 460 | 0.03 | 1.2e-04 | -10.1 | 12.6 | 2.4e-36 | 0.23 | 0.59 | 0.01 | TRUE |
| 11 | The Cancer Genome Atlas | Stomach Adenocarcinoma | TIGD2 | 0.06 | 0.02 | lasso | 3 | 0.01 | 3.6e-02 | -11.5 | -12.3 | 1.4e-34 | -0.28 | 0.08 | 0.08 | TRUE |
| 9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FAM13A | 0.03 | 0.02 | lasso | 3 | 0.01 | 8.8e-04 | -5.2 | -9.9 | 3.7e-23 | -0.34 | 0.35 | 0.12 | TRUE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | NAP1L5 | 0.12 | 0.03 | blup | 396 | 0.04 | 2.8e-06 | -5.0 | -7.8 | 9.0e-15 | -0.19 | 0.96 | 0.00 | TRUE |
| 5 | METSIM | Adipose | NAP1L5 | 0.04 | 0.00 | bslmm | 404 | 0.01 | 4.2e-03 | -3.2 | 7.3 | 2.8e-13 | 0.58 | 0.04 | 0.62 | TRUE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | FAM13A | 0.12 | 0.13 | lasso | 3 | 0.13 | 5.9e-16 | -6.3 | 6.5 | 8.9e-11 | -0.04 | 1.00 | 0.00 | TRUE |
| 1 | CommonMind | Brain Pre-frontal Cortex | GPRIN3 | 0.16 | 0.09 | bslmm | 481 | 0.11 | 3.5e-13 | -4.0 | -5.5 | 3.7e-08 | -0.22 | 1.00 | 0.00 | TRUE |
| 10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FAM13A | 0.06 | 0.00 | blup | 220 | 0.02 | 2.4e-03 | 3.8 | -8.6 | 7.1e-18 | -0.02 | 0.09 | 0.03 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | TIGD2 | 0.09 | 0.00 | bslmm | 464 | 0.02 | 7.0e-04 | 3.7 | 8.3 | 6.7e-17 | 0.27 | 0.09 | 0.04 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | FAM13A | 0.12 | 0.00 | enet | 7 | 0.01 | 6.9e-02 | -10.7 | 7.4 | 1.0e-13 | 0.10 | 0.26 | 0.04 | FALSE |
| 4 | GTEx | Vagina | GPRIN3 | 0.42 | 0.08 | lasso | 3 | 0.07 | 1.1e-02 | -4.7 | -5.5 | 4.8e-08 | -0.01 | 0.09 | 0.06 | FALSE |