Hub : Genes

TIGD2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0940 0.0380 2.8e-03 0.001 0.018 0.007 0.023 0.002 0.220 2.5e-03 3.7e-02 0.00070 1.9e-01
2 GTEx Stomach 0.1270 0.0570 6.0e-03 -0.005 NA -0.005 NA -0.003 0.630 NA 7.0e-01 NA 4.8e-01
3 GTEx Testis 0.1850 0.0830 7.8e-03 -0.006 NA 0.007 NA -0.006 0.900 NA 1.5e-01 NA 8.1e-01
4 ROSMAP Brain Pre-frontal Cortex 0.0631 0.0211 6.7e-04 0.012 0.028 0.019 0.028 0.020 0.010 1.2e-04 1.5e-03 0.00012 1.1e-03
5 TCGA Breast Invasive Carcinoma 0.0279 0.0137 4.5e-04 0.007 0.016 0.010 NA 0.009 0.012 2.1e-04 2.9e-03 NA 4.9e-03
6 TCGA Kidney Renal Clear Cell Carcinoma 0.0608 0.0245 8.0e-07 0.012 0.066 0.073 NA 0.065 0.015 6.1e-08 1.3e-08 NA 8.5e-08
7 TCGA Stomach Adenocarcinoma 0.0600 0.0310 3.8e-03 0.021 0.013 0.004 NA 0.013 0.011 3.9e-02 1.5e-01 NA 3.6e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.8 1.3 3.9 0.1 1.1 -1.0 0.1 0.3 1.7 2.0
Bipolar Disorder or Schizophrenia 0.9 2.2 3.6 0.4 1.7 -1.9 -0.9 1.7 1.6 1.6
Depressed Affect (Nagel 2018) 0.9 1.9 5.1 1.6 2.3 -0.0 -1.2 1.5 1.4 -0.3
Depression (Nagel 2018) 0.5 0.7 3.1 0.3 1.8 0.5 0.1 0.7 0.8 -0.4
Intelligence (Savage-Jansen 2018) 0.2 0.8 2.9 -0.7 -0.1 1.7 -1.3 -0.0 0.2 0.5
Neuroticism (Nagel 2018) 1.1 2.5 6.7 0.9 2.6 -0.7 -2.2 1.3 1.7 0.2
Schizophrenia (2018) 0.7 1.5 3.8 0.5 1.3 -1.6 -1.2 2.0 0.7 0.5
Schizophrenia vs Biploar Disorder 0.8 1.1 2.1 1.3 0.1 -0.4 -1.0 1.5 -0.8 -1.4
Worry (Nagel 2018) 1.0 2.2 5.0 1.1 2.0 -0.9 -2.2 1.0 1.6 0.7
Alzheimer’s Disease (in mother) 0.6 0.8 1.7 -0.8 0.4 -0.7 -0.9 0.9 1.3 0.9
Alzheimer’s Disease (in father) 0.2 0.2 0.5 0.6 0.7 -0.1 -0.3 0.1 0.2 -0.6
Alzheimer’s Disease (including proxy) 0.3 0.4 1.1 0.0 0.3 -1.1 -0.2 0.4 1.0 0.6
Crohns Disease (2017) 1.2 2.7 8.4 2.1 0.4 -2.2 2.9 -0.7 0.2 0.7
Irritable Bowel Disease (IBD) 1.0 2.3 8.8 1.6 0.2 -2.0 3.0 0.5 -0.1 0.6
Ulcerative Colitis (UC) 0.8 1.5 4.9 0.7 0.1 -1.4 2.2 1.7 -0.2 0.6
Major Depression (MDD) 0.6 0.7 2.4 -0.8 0.6 -0.5 1.1 0.4 0.1 1.5
Reaction Time 2.2 4.2 11.1 -1.7 2.0 -2.4 1.6 0.6 1.5 3.3
Verbal and Numeric Reasoning (VNR) 0.3 0.8 1.8 -1.1 -0.6 1.4 -1.0 -0.6 0.1 1.1
Breast Cancer 0.5 1.1 3.8 -0.2 0.0 -0.8 -1.1 0.6 2.0 1.3
Ovarian Cancer 0.8 1.0 2.1 1.0 -1.2 0.5 -0.9 -1.4 -0.1 -1.2
Prostate Cancer 0.6 0.8 4.3 -0.3 0.1 0.4 -2.1 0.7 0.9 -0.3
Age at First Birth 0.4 0.5 1.5 1.1 0.5 -0.2 1.2 -0.2 0.7 0.1
Bipolar Disorder (2011) 0.6 0.6 2.4 -0.1 0.3 0.1 0.2 0.5 1.5 1.2
Body Mass Index (BMI) (2010) 0.2 0.2 0.7 0.8 0.2 0.2 -0.2 0.8 -0.1 0.3
Coronary Artery Disease (CAD) 0.6 0.7 1.6 1.0 0.7 -1.3 -1.0 0.4 0.7 0.3
Crohns Disease (2012) 1.1 1.8 4.4 2.1 0.1 -2.0 1.8 -0.7 0.3 0.5
Mean Putamen Volume 1.2 1.4 3.8 0.7 1.5 1.5 -0.6 1.9 0.8 -0.1
Fasting Glucose 0.1 0.1 0.3 0.4 0.4 0.6 0.3 0.2 0.2 0.1
HbA1C 0.4 0.4 2.0 1.4 -0.1 0.7 0.6 -0.3 -0.1 -0.5
HDL Cholesterol 0.3 0.6 1.5 -1.2 -1.0 0.5 0.2 -0.6 -0.9 -0.0
LDL Cholesterol 0.1 0.2 0.3 0.5 0.1 0.4 -0.4 -0.5 0.1 -0.5
Lupus 1.5 2.3 8.8 -1.6 -1.5 1.2 -3.0 -1.0 -0.1 0.2
Neuroticism (2016) 1.1 1.6 3.2 -0.6 -1.6 -0.5 -0.6 -1.8 -1.2 -1.7
Primary Biliary Cirrhosis 0.4 0.5 1.3 -0.0 -0.2 -0.7 1.0 -1.2 -0.8 -0.1
Rheumatoid Arthritis 0.4 0.5 1.2 -0.7 0.9 0.3 -1.1 0.4 0.3 0.8
Schizophrenia (2014) 0.9 1.9 3.8 0.6 1.6 -1.7 -1.0 2.0 1.3 1.1
Triglycerides 0.6 1.1 4.2 -0.1 -0.4 -1.3 0.5 -0.6 0.9 2.0
Type 2 Diabetes (T2D) (2012) 1.0 1.1 2.5 1.6 1.1 0.0 1.3 1.1 1.1 -0.4
Ulcerative Colitis 0.5 0.7 1.3 -1.1 -0.9 -0.6 -0.5 0.6 -0.7 1.0
Blood Eosinophil Count 1.1 8.4 31.4 -0.0 1.4 -5.6 0.2 1.7 3.0 3.6
Blood Platelet Count 0.5 5.6 24.1 -2.3 0.1 0.7 -4.9 1.6 1.0 2.4
Blood Red Count 0.7 7.1 18.2 -0.0 -0.2 -3.8 4.3 -0.6 0.7 4.0
Blood White Count 1.1 7.9 22.2 -0.9 2.0 -3.0 -0.9 2.8 3.3 4.7
Heel T-Score 0.4 3.4 8.6 -0.1 2.9 0.6 0.2 2.4 1.8 2.3
BMI 0.2 1.1 2.8 -1.7 -1.2 -1.0 0.3 -0.7 -1.0 0.9
Height 0.1 2.2 10.5 0.9 -0.1 0.9 -1.2 0.2 -1.3 -3.2
Waist Hip Ratio (WHR) 1.1 5.0 13.0 1.2 3.1 -0.4 -1.9 1.9 3.6 1.9
Systolic Blood Pressure 1.3 6.4 14.7 0.4 2.8 -3.8 -1.5 1.7 3.7 1.9
Smoking Status 0.1 0.3 1.5 -0.0 0.2 -0.5 -1.2 0.1 0.8 0.3
Allergy or Eczema 0.1 0.3 1.0 1.0 0.8 0.7 0.4 0.0 0.1 0.0
Cardiovascular Disease 1.0 3.4 7.6 -1.9 1.0 -2.6 -0.6 1.0 1.8 2.8
Hypothyroidism (self reported) 0.2 0.4 2.1 0.7 -0.1 0.2 1.4 0.5 -0.1 0.4
Respiratory disease 2.8 6.2 11.7 3.4 3.2 -1.3 0.2 3.2 2.9 1.0
Type 2 Diabetes (T2D) (2018) 0.5 1.0 2.3 1.5 0.0 -1.2 1.4 0.4 0.7 -0.8
Lung FEV1/FVC ratio 12.1 61.3 158.8 8.3 2.0 5.0 12.6 -2.6 -3.7 -12.3
Lung FVC 2.2 11.2 44.0 -4.3 -0.1 0.7 -6.6 0.7 1.6 3.6
Neuroticism 1.9 4.6 11.0 1.3 3.3 -1.5 -2.4 2.0 2.6 0.6
Chronotype (morning person) 1.8 4.2 13.0 1.7 0.3 -3.1 3.6 -0.5 0.4 1.6
Hair Pigment 0.1 2.4 5.6 0.1 -1.4 0.7 2.4 -2.1 -2.1 -0.7
Tanning 0.1 1.0 2.9 -1.7 -0.6 0.1 1.3 -0.5 -1.0 -0.9
Hand grip strength (left) 0.5 1.2 3.1 0.7 1.8 1.5 -0.5 1.3 0.6 0.0
Number of treatments/medications taken 0.1 0.2 0.4 -0.5 0.5 -0.5 0.4 -0.2 0.6 -0.4
Average weekly spirits intake 0.1 0.2 0.5 -0.5 0.7 -0.0 -0.1 0.5 0.2 -0.2
Sensitivity / hurt feelings 0.3 0.5 1.9 0.3 0.9 -0.7 -1.4 0.3 -0.1 0.2
Frequency of depressed mood in last 2 weeks 0.4 0.5 2.3 0.2 1.5 -0.5 0.1 0.6 0.6 -0.4
Hearing difficulty/problems: Yes 0.5 0.8 2.7 -0.8 0.7 1.6 0.9 -0.3 0.6 0.4
Relative age of first facial hair 0.5 1.1 4.7 2.2 1.0 -0.7 0.1 0.6 1.1 -0.2
Other serious medical condition/disability diagnosed by doctor 1.1 1.4 6.4 -1.1 -0.9 0.7 -0.7 -2.5 -0.6 -0.3
Ever used hormone-replacement therapy (HRT) 3.6 4.6 7.7 2.6 2.8 -2.5 0.8 1.7 2.7 0.8
Ever had hysterectomy (womb removed) 1.3 1.5 5.0 1.3 -0.2 -0.6 2.2 -0.2 -1.2 -1.4
Systolic blood pressure, automated reading 0.9 2.6 11.6 -0.1 1.2 -3.4 -0.2 0.3 1.9 1.2
Eye problems/disorders: Diabetes related eye disease 0.7 0.8 2.5 0.4 -1.1 0.6 0.0 -1.6 -0.3 -1.1
Angina 0.4 0.5 1.4 -1.0 -1.2 0.6 -0.4 0.6 -0.6 0.0
Medication for hormone replacement therapy 0.8 0.9 2.6 -1.1 -0.6 1.6 -1.4 -0.2 -0.4 -0.0
Vitamin and mineral supplements 0.9 1.3 3.3 0.7 -1.1 -1.8 1.8 -0.6 -0.5 0.4
Supplements: Zinc 1.0 1.1 2.2 -1.5 -0.5 1.2 -1.4 -1.1 -0.8 -0.4
Medication: Co-codamol 1.4 1.6 2.2 -1.1 1.4 -1.4 -1.4 0.4 1.3 1.5
Medication: Metformin 1.9 2.6 6.3 1.8 1.1 -2.3 2.5 0.7 1.4 0.1
Diabetes (father) 0.2 0.2 1.0 -0.3 0.5 0.0 1.0 -0.1 0.2 -0.0
Diabetes (mother) 0.7 0.9 2.7 0.5 0.3 -1.1 -1.3 1.6 0.7 0.3
Severe depression (siblings) 0.5 0.6 1.9 -0.4 -0.7 1.1 -1.4 -0.3 -0.1 -0.5
Pack years adult smoking proportion 1.5 2.3 4.2 1.3 1.8 -1.9 1.0 0.2 2.0 1.5
Impedance of leg (right) 0.6 3.0 10.2 3.2 1.6 0.5 2.1 1.8 0.4 -0.4
Leg fat-free mass (left) 0.3 1.5 4.5 -2.1 -1.2 -0.4 -1.7 -0.8 -1.1 -0.2
Trunk fat percentage 0.5 2.0 4.1 -1.2 -1.6 -1.9 1.1 -0.7 -2.0 0.3
Hand grip strength (right) 0.6 1.5 3.8 1.1 1.5 1.9 -0.6 1.7 0.6 0.3
Townsend deprivation index at recruitment 0.8 1.2 2.1 1.5 1.3 -1.4 1.1 0.8 0.5 0.5
Current tobacco smoking 1.0 1.6 4.3 0.8 2.0 -0.3 0.0 2.1 1.4 0.8
Average weekly fortified wine intake 2.2 2.6 5.5 -2.3 -2.0 1.0 -1.1 -2.3 -1.3 0.1
Maternal smoking around birth 2.3 3.4 6.1 1.7 2.4 -1.5 -0.6 2.0 2.5 1.5
Fed-up feelings 1.4 2.6 6.1 1.3 2.5 -1.6 -0.7 1.4 2.3 0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 1.8 0.8 1.4 -0.0 0.8 0.1 0.6 -0.3
Relative age voice broke 0.2 0.4 0.9 0.1 -0.6 -0.4 0.9 -0.9 -0.2 -0.6
Taking other prescription medications 0.3 0.4 1.0 0.8 1.0 -0.3 0.4 -0.3 0.9 0.0
Age when periods started (menarche) 0.4 0.9 3.9 -0.3 0.4 2.0 -1.4 0.1 0.4 -0.5
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 2.2 0.6 1.5 -0.2 0.4 0.6 1.3 0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 0.7 -0.7 0.8 0.4 0.8 0.6 0.7 0.1
Tinnitus: Yes, but not now, but have in the past 1.4 1.5 3.2 1.6 0.6 1.8 0.4 1.1 -0.1 -1.8
Qualifications: CSEs or equivalent 0.6 0.8 2.4 -0.5 -1.1 -0.6 0.1 -1.0 -1.6 0.4
Serious illness, injury or assault to yourself 0.6 0.7 1.2 -0.5 -0.3 1.1 -0.9 -1.0 -0.8 -1.0
High blood pressure 1.9 5.3 10.7 0.8 2.5 -3.2 0.5 2.3 3.3 2.1
Hayfever, allergic rhinitis or eczema 0.5 1.1 4.2 2.1 1.3 0.5 0.8 0.6 0.1 -0.7
Multivitamins +/- minerals 0.8 1.0 2.9 -1.7 0.3 1.6 -1.0 -0.7 -0.0 -0.1
Stomach or abdominal pain in last month 0.9 1.2 3.1 1.7 1.8 -0.4 0.4 -0.0 1.4 0.1
Supplements: Glucosamine 0.5 0.6 1.4 -0.4 -1.1 1.2 0.2 -1.0 -0.6 -0.6
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 2.5 -0.1 -0.4 -1.6 0.3 -1.5 0.1 0.7
Medication: Atenolol 1.1 1.3 3.6 -1.9 -1.3 0.5 -1.5 -1.0 -0.8 -0.3
Medication: Levothyroxine sodium 0.6 1.1 2.2 -0.8 -0.9 1.1 1.5 -1.2 -0.9 -0.7
Sitting height 0.0 0.2 1.1 -0.1 -0.0 -0.4 -1.0 0.2 0.1 -0.5
Chronic bronchitis/emphysema (father) 1.9 2.2 8.7 -0.9 0.9 -0.7 -0.8 1.8 0.9 2.9
High blood pressure (mother) 1.7 2.3 8.8 0.2 0.9 -3.0 0.3 0.6 1.3 2.1
Body mass index (BMI) 0.1 0.6 1.3 -1.1 -0.6 -1.1 0.3 -0.4 -0.7 0.3
Impedance of leg (left) 0.4 2.0 7.7 2.8 1.5 0.3 1.7 1.1 0.2 -0.3
Leg predicted mass (left) 0.3 1.5 4.5 -2.1 -1.2 -0.4 -1.6 -0.8 -1.1 -0.2
Trunk fat mass 0.3 1.3 3.3 -1.1 -1.2 -1.8 0.6 -0.5 -1.7 0.1
Waist circumference 0.1 0.2 1.0 -0.1 0.1 -1.0 -0.7 0.0 -0.0 0.0
Number of incorrect matches in round 0.7 1.2 2.2 1.5 1.1 -1.4 1.1 0.2 1.4 -0.3
Past tobacco smoking 0.6 1.1 2.3 -1.5 -0.3 1.1 1.5 -0.7 -0.8 0.5
Alcohol usually taken with meals 0.4 0.6 2.0 -0.5 -1.4 0.5 0.3 -1.0 -1.0 -0.1
Nervous feelings 0.5 1.0 1.8 1.1 1.3 -1.3 -0.8 0.7 0.8 0.6
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.2 2.5 1.1 1.4 -1.6 -0.6 0.1 1.2 0.8
Hearing difficulty/problems with background noise 0.4 0.6 2.5 -0.4 -0.8 -0.0 1.6 -0.8 -0.1 -0.8
Hair/balding pattern: Pattern 2 0.5 0.6 3.2 0.1 0.5 0.0 -1.8 0.3 0.9 -0.3
Had menopause 0.5 0.6 2.1 0.8 1.0 -0.6 -0.0 0.2 1.5 0.5
Had other major operations 0.5 0.6 2.0 0.9 0.1 0.6 1.4 -0.8 -0.1 -0.7
Forced vital capacity (FVC) 1.0 3.9 14.6 -2.7 -1.0 1.4 -3.8 0.0 0.1 1.6
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.2 2.5 -0.7 1.6 0.8 0.6 1.4 1.5 0.3
Ever unenthusiastic/disinterested for a whole week 1.2 1.5 3.5 1.9 1.6 0.6 -0.5 1.6 0.9 -0.4
Qualifications: None of the above 0.5 1.0 4.5 1.0 -0.3 -0.5 2.1 -0.4 -1.0 -0.5
Financial difficulties in last 2 years 1.4 1.9 3.2 -0.0 1.8 -1.6 -1.5 0.9 1.5 1.5
Mouth/teeth dental problems 0.3 0.5 1.7 -0.3 0.8 0.9 -0.2 1.3 0.4 0.1
Heart attack 0.8 1.0 1.7 -0.7 -1.1 1.2 -1.3 -0.6 -0.7 -1.1
Allergy 1.2 2.8 6.4 -2.5 -2.5 0.7 -0.8 -1.5 -1.7 -0.6
Pain all over the body in last month 1.0 1.0 3.6 1.3 1.0 -0.7 1.9 0.6 0.2 -0.3
Diabetes (self-reported) 0.7 1.1 4.0 0.9 -0.7 -1.3 2.0 -0.1 0.4 -0.9
Hayfever/allergic rhinitis (self-reported) 0.9 1.1 4.2 0.6 -0.3 0.6 0.4 -0.3 -1.6 -2.1
Medication: Ramipril 0.9 1.1 2.7 0.0 1.4 -1.7 0.1 0.2 1.6 0.7
Medication: Simvastatin 0.6 0.9 2.6 -0.9 -0.5 -1.6 -0.8 0.2 0.7 1.2
Fluid intelligence score 0.8 1.7 3.7 -0.4 0.3 1.9 -1.9 0.7 1.0 1.8
Illnesses of siblings 2.2 3.1 7.0 0.3 -1.4 2.6 -0.3 -1.7 -2.1 -2.4
Neuroticism score 1.1 2.4 6.9 0.8 2.6 -1.4 -1.4 1.4 1.7 0.8
Weight 0.2 0.8 1.7 -1.3 -0.8 -1.0 -0.3 -0.7 -1.2 -0.4
Impedance of arm (right) 0.3 1.4 5.6 0.1 -1.4 0.1 0.9 -0.6 -2.4 -0.8
Arm fat percentage (right) 0.4 1.6 4.3 -0.6 -1.5 -1.4 1.3 -0.9 -2.1 -0.5
Trunk fat-free mass 0.1 0.6 2.0 -0.2 1.1 0.2 -1.4 0.4 0.7 -0.7
Hip circumference 0.4 1.6 4.0 -1.1 -1.7 -0.6 0.0 -1.4 -2.0 -0.7
Time employed in main current job 0.6 0.7 1.7 -0.3 -1.2 -0.3 -0.9 -0.5 -1.3 -0.5
Alcohol intake versus 10 years previously 0.3 0.4 1.4 -0.8 0.1 -0.7 -1.2 0.4 0.2 0.1
Father’s age at death 0.7 1.0 2.8 -0.2 1.1 1.0 -1.7 0.5 1.2 -0.4
Worrier / anxious feelings 0.2 0.3 0.9 0.1 0.0 -0.9 -1.0 0.5 -0.4 -0.3
Frequency of tiredness / lethargy in last 2 weeks 2.0 3.2 7.6 2.2 2.8 -0.5 -0.7 2.0 2.2 0.5
Falls in the last year 0.5 0.7 3.5 0.1 0.7 -0.3 1.9 -0.9 0.1 0.4
Hair/balding pattern: Pattern 3 0.9 1.3 4.5 -0.5 -0.3 -1.4 2.1 -1.2 0.0 1.0
Number of live births 1.2 1.8 3.7 0.8 -0.8 1.3 1.9 -0.5 -1.4 -1.9
Forced expiratory volume in 1-second (FEV1) 0.5 1.6 8.0 -0.6 -0.5 2.8 -0.3 -0.6 -0.6 -1.4
Pulse rate 2.3 3.9 8.0 1.0 2.8 -2.4 0.2 1.6 2.5 2.0
Happiness 1.4 1.7 4.2 1.9 1.2 0.6 -1.3 2.0 0.8 -0.4
Noisy workplace 1.7 2.0 8.2 1.9 0.8 0.0 2.9 0.0 -0.8 -1.1
Qualifications: A levels/AS levels or equivalent 0.2 0.4 0.7 -0.5 -0.7 0.8 -0.8 -0.6 -0.1 -0.3
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 2.2 -0.6 -1.0 -0.6 -0.5 -1.1 -1.1 -1.5
Mouth/teeth dental problems: Dentures 0.6 1.0 2.2 1.1 -0.6 -1.5 1.2 -1.0 -0.5 0.0
Asthma 2.3 4.6 10.0 2.2 2.9 -1.6 0.1 2.2 3.2 1.4
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 3.0 -1.7 -0.7 0.1 -0.2 -1.0 -0.7 0.8
Medication: Cholesterol lowering 1.0 1.5 2.7 -0.7 1.0 -1.5 -0.6 1.4 1.5 1.6
Depression (self-reported) 0.2 0.2 0.7 0.3 0.3 -0.2 0.8 0.3 -0.1 -0.8
Medication: Lansoprazole 0.8 0.9 4.0 -1.0 -1.0 2.0 -0.4 -0.4 -0.3 0.0
Prospective memory result 1.5 1.8 3.3 0.5 -1.3 -0.7 1.8 -1.4 -1.4 -1.8
Lung cancer (father) 0.8 1.0 2.5 1.6 1.2 -0.4 0.2 1.2 1.1 -0.5
Illnesses of mother 2.2 2.7 8.0 -0.9 -1.2 2.8 0.7 -2.0 -1.5 -1.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 2.8 11.2 -1.1 -0.8 3.4 -0.7 -0.9 -1.4 -1.8
Pulse wave Arterial Stiffness index 0.4 0.5 1.6 -0.6 0.1 -0.1 0.9 -1.3 -0.3 0.9
Impedance of arm (left) 0.7 3.2 10.1 -1.4 -2.7 0.5 0.0 -1.5 -3.2 -0.7
Arm fat mass (right) 0.1 0.5 1.5 -0.7 -0.7 -1.0 0.3 -0.3 -1.2 -0.3
Trunk predicted mass 0.1 0.8 2.2 -0.1 1.3 0.0 -1.5 0.5 0.9 -0.6
Standing height 0.1 0.9 3.4 -0.6 -0.2 0.4 -1.9 -0.4 -0.9 -1.2
Length of working week for main job 0.5 0.6 2.5 -0.4 0.4 -0.3 1.6 -0.7 -0.4 0.6
Exposure to tobacco smoke at home 0.5 0.5 1.8 -0.1 0.3 0.3 -1.4 -0.3 0.8 1.1
Breastfed as a baby 0.6 0.8 2.1 -0.9 -0.4 1.0 1.1 -1.4 -0.1 -0.1
Tense / ‘highly strung’ 0.4 0.6 1.4 1.2 1.2 -0.5 -0.5 -0.5 0.7 -0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.3 3.1 0.2 1.8 -0.7 1.0 1.7 1.0 0.7
Hair/balding pattern: Pattern 4 1.3 3.1 7.1 -1.1 -1.9 1.4 1.2 -1.6 -2.7 -1.8
Birth weight of first child 1.1 2.1 7.3 0.8 0.2 2.1 1.2 -0.6 -0.4 -2.7
Peak expiratory flow (PEF) 1.5 3.5 11.8 1.0 -0.7 3.4 1.8 -0.9 -1.0 -2.6
Pulse wave reflection index 1.1 1.4 4.8 -1.2 -0.7 0.2 1.1 -2.2 -1.3 0.1
Ever highly irritable/argumentative for 2 days 0.6 0.7 1.4 0.1 0.7 1.2 -1.1 1.1 0.3 0.5
Loud music exposure frequency 2.1 2.3 7.2 0.5 1.8 -2.7 1.2 0.8 1.4 1.1
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 1.1 0.2 -0.9 0.1 1.0 -0.2 -1.0 -0.8
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 3.4 -1.8 -1.3 0.1 -1.1 -1.4 -0.6 -0.6
Blood clot in the leg (DVT) 0.5 0.6 1.5 -0.1 -0.5 -0.7 0.9 -1.1 -0.3 -1.2
Medication: Paracetamol 0.2 0.3 0.8 -0.4 -0.4 -0.3 -0.9 -0.0 -0.6 -0.6
Headache pain in last month 0.3 0.5 1.3 -0.0 1.0 1.2 -0.7 0.6 0.1 0.5
Medication for cholesterol, blood pressure or diabetes 1.1 1.9 7.3 1.0 -0.8 2.7 0.3 -1.1 -1.2 -1.3
Glaucoma (self-reported) 2.3 2.7 6.5 1.2 2.2 -1.1 0.2 1.5 2.5 1.6
Gout (self-reported) 0.8 1.1 4.5 -0.4 -0.6 -2.1 -0.1 -0.2 0.4 1.5
Hypothyroidism/myxoedema (self-reported) 0.2 0.5 3.1 0.1 0.0 -0.2 1.8 -0.2 0.1 0.4
Medication: Amlodipine 1.3 1.8 10.0 -0.5 0.6 -3.2 0.2 0.5 1.1 0.6
Medication: Ventolin 100micrograms inhaler 2.3 2.9 6.2 0.7 2.5 -2.0 0.9 0.8 2.3 1.8
Birth weight 2.8 6.1 11.6 -1.4 -2.4 2.0 -2.0 -2.9 -2.5 -3.4
Chronic bronchitis/emphysema (mother) 0.4 0.5 1.2 0.3 0.4 -0.6 -0.3 0.8 1.1 1.0
High blood pressure (siblings) 1.7 2.5 5.2 -0.1 1.7 -2.3 0.4 1.4 2.0 1.8
Forced vital capacity (FVC), Best measure 1.5 5.7 18.4 -3.5 -1.3 2.3 -4.3 -0.5 -0.6 1.3
Body fat percentage 0.4 1.7 4.6 -0.5 -1.4 -1.6 1.4 -0.6 -2.1 -0.3
Leg fat percentage (right) 0.4 1.4 4.8 1.2 0.3 -1.6 2.2 0.5 -0.5 -0.4
Arm fat-free mass (right) 0.1 0.4 1.7 -0.6 0.1 -0.1 -1.3 -0.0 0.2 -0.5
Exposure to tobacco smoke outside home 1.0 1.4 3.5 1.0 1.9 -0.7 -0.5 1.4 1.6 0.1
Comparative body size at age 10 0.5 1.3 4.0 -2.0 -0.1 0.6 -1.2 -0.6 0.5 1.7
Number of full brothers 0.4 0.6 1.1 0.6 0.8 0.2 1.1 0.8 0.9 0.6
Worry too long after embarrassment 1.0 1.7 3.9 0.3 2.0 -0.9 -1.2 0.7 1.9 1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 1.1 1.4 3.1 0.7 1.8 -0.8 1.4 1.5 1.2 0.7
Wheeze or whistling in the chest in last year 1.9 3.3 6.5 0.2 2.1 -2.2 0.0 1.2 2.5 2.5
Number of children fathered 1.1 1.2 3.9 0.4 -0.1 2.0 0.7 -0.1 -1.1 -1.7
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 1.2 -0.8 0.2 -1.0 -0.7 -0.5 0.3 1.1
Age at first live birth 0.5 0.9 2.8 -0.8 0.2 -0.1 -1.7 0.5 1.3 0.9
Pulse wave peak to peak time 0.5 0.6 1.8 0.6 -0.1 0.2 -1.0 1.3 0.2 -1.0
Health satisfaction 0.3 0.4 1.1 0.6 0.7 0.1 -1.1 0.5 0.5 -0.0
Shortness of breath walking on level ground 1.1 1.3 2.1 -0.5 0.3 -1.5 -1.4 1.4 0.8 1.4
Qualifications: College or University degree 1.0 3.2 19.1 -1.1 0.3 0.9 -4.4 0.2 1.0 0.5
Eye problems/disorders: None of the above 0.6 0.7 1.5 -0.0 -1.2 0.5 0.1 -0.8 -1.1 -1.0
Mouth/teeth dental problems: Loose teeth 0.3 0.3 1.1 -0.2 -0.2 -0.8 -0.7 1.0 0.0 0.4
Emphysema/chronic bronchitis 0.6 0.7 2.6 0.5 0.1 0.3 -0.9 0.3 0.9 1.6
Medication for pain relief, constipation, heartburn 0.3 0.6 2.0 1.4 0.6 0.6 0.7 0.5 0.6 -0.3
Neck or shoulder pain in last month 2.1 2.9 5.8 2.4 2.1 1.5 -0.7 1.7 2.0 -1.0
Medication: Blood pressure 1.2 2.1 11.1 -0.2 0.8 -3.3 0.6 0.9 1.1 0.9
Angina (self-reported) 0.4 0.5 1.6 -0.8 -1.2 0.5 -0.3 0.7 -0.7 -0.2
Migraine (self-reported) 0.5 0.6 1.6 0.8 1.3 0.7 0.7 0.8 0.4 0.7
Medication: Ibuprofen 0.9 1.1 2.8 -1.7 -1.2 0.5 -0.7 -1.4 -0.9 0.4
Medication: Allopurinol 0.8 1.0 4.1 -0.6 -0.3 -2.0 0.5 -0.2 0.3 1.5
Medication: Omeprazole 0.4 0.4 1.0 -1.0 0.3 0.0 -1.0 0.7 0.5 0.2
Medication: Seretide 50 evohaler 0.7 0.8 2.3 0.8 -0.2 -1.5 1.0 0.8 0.9 0.1
Mean time to correctly identify matches 1.8 3.4 9.0 -1.2 1.2 -3.0 1.9 -0.2 1.1 2.7
Heart disease (mother) 0.7 0.8 3.0 1.2 0.6 0.2 1.7 0.4 0.1 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.3 0.9 0.3 -0.7 -0.4 0.9 -0.5 -0.7 0.0
Whole body fat mass 0.2 0.9 2.3 -0.6 -0.9 -1.4 0.8 -0.4 -1.5 -0.2
Leg fat mass (right) 0.2 0.6 1.6 0.1 -0.3 -1.3 1.1 0.1 -1.1 -0.6
Arm predicted mass (right) 0.1 0.3 1.7 -0.4 0.2 -0.1 -1.3 0.1 0.2 -0.5
Pulse rate, automated reading 2.5 8.2 14.6 1.1 3.4 -3.8 0.1 2.8 3.8 2.8
Alcohol intake frequency. 0.2 0.4 2.1 1.5 -0.1 -0.4 0.3 0.7 0.4 0.4
Comparative height size at age 10 0.4 2.3 4.5 -2.1 -1.7 0.5 -1.6 -1.3 -1.5 -1.4
Number of full sisters 0.7 0.8 2.3 1.5 1.0 -0.3 -0.1 1.1 0.3 0.9
Suffer from ‘nerves’ 0.7 1.1 2.8 -1.0 0.5 -1.7 -1.3 -1.0 0.5 0.9
Overall health rating 0.1 0.3 1.1 0.5 0.1 -1.1 -0.4 -0.1 0.6 0.1
Chest pain or discomfort 0.7 1.0 2.4 0.5 1.3 -0.9 -0.5 0.8 1.6 1.1
Had major operations 0.4 0.4 1.8 -1.3 -0.0 0.6 -0.3 0.1 -0.0 0.9
Age at last live birth 0.2 0.4 1.5 0.0 0.2 -0.4 -0.6 0.3 1.2 0.6
Family relationship satisfaction 0.8 1.0 2.2 1.5 0.9 -1.2 -0.7 1.0 1.0 0.3
Leg pain on walking 0.7 0.8 2.0 1.3 -0.0 0.3 1.4 0.1 -0.4 -1.4
Qualifications: NVQ or HND or HNC or equivalent 4.7 5.7 8.5 -1.5 -2.6 2.7 2.6 -2.6 -2.9 -1.2
Commuting to job workplace: Car/motor vehicle 0.8 0.9 1.7 -1.1 -1.3 -0.3 0.7 -1.2 -1.2 -0.1
Illness, injury, bereavement, stress in last 2 years 0.2 0.3 0.7 0.4 -0.0 0.6 0.1 0.8 0.6 0.6
Medication: Aspirin 0.5 0.7 1.4 0.0 0.5 -1.2 -1.1 1.0 0.9 0.5
Supplements: Vitamin C 0.2 0.3 1.1 -0.4 -0.1 0.5 -1.0 0.5 -0.2 0.0
Knee pain experienced in last month 0.5 0.8 4.2 0.0 0.4 0.9 -2.1 -0.6 0.4 -0.3
Hypertension (Self-reported) 1.6 4.5 9.3 0.4 2.2 -3.0 0.7 2.0 2.9 2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.1 3.2 -0.4 -1.2 0.4 -0.3 -1.8 -1.1 -1.2
Illnesses of father: Heart disease 0.8 1.1 5.9 0.7 1.0 -0.2 2.4 0.4 0.2 -0.5
Illnesses of siblings: Diabetes 1.4 1.7 6.5 0.5 -0.7 -2.6 1.9 -0.4 -0.1 0.8
Smoking status: Previous 0.4 0.6 1.2 1.1 -0.8 -0.6 -0.6 -0.4 0.1 -1.1
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 1.7 -1.3 -0.8 0.6 -1.0 -0.5 -1.3 0.4
Whole body fat-free mass 0.1 0.6 2.8 -1.1 0.2 -0.1 -1.7 -0.2 0.0 -0.4
Leg fat-free mass (right) 0.4 2.0 5.8 -2.4 -1.3 -0.5 -1.9 -1.2 -1.2 -0.1
Arm fat percentage (left) 0.5 2.2 5.9 -1.2 -2.0 -1.2 0.9 -1.1 -2.4 -0.3
Average weekly red wine intake 0.2 0.3 0.7 -0.9 -0.3 0.5 -0.8 0.0 -0.4 -0.7
Handedness (chirality/laterality): Left-handed 0.3 0.3 0.7 0.4 0.8 0.2 -0.5 0.8 0.8 -0.0
Mood swings 0.1 0.3 0.5 -0.5 0.7 0.2 -0.3 -0.5 -0.7 -0.5
Loneliness, isolation 0.7 0.9 2.1 0.7 1.4 -0.5 -1.3 1.2 0.5 0.3
Long-standing illness, disability or infirmity 0.2 0.3 1.1 0.3 0.4 -0.3 -0.6 -0.7 1.0 0.1
Ever had bowel cancer screening 0.8 1.0 3.4 1.0 0.2 -1.8 0.4 -0.7 0.1 -1.4
Diabetes diagnosed by doctor 0.6 0.9 2.9 0.9 -0.5 -1.3 1.7 -0.2 0.6 -0.9
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.7 1.9 -1.2 0.7 -0.7 -0.5 0.3 1.4 0.9
Friendships satisfaction 3.3 4.1 8.3 1.6 2.6 -0.5 -1.7 2.9 2.6 0.9
Qualifications: nursing, teaching 0.3 0.4 2.2 -0.6 0.3 -0.4 -0.2 -0.0 0.6 1.5
Commuting to job workplace: Walk 0.9 0.9 2.3 -0.2 1.1 1.5 -0.8 1.3 0.5 -0.8
Eye problems/disorders: Cataract 0.4 0.4 1.5 0.4 0.8 -1.2 0.1 0.7 0.4 -0.3
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.9 0.5 -0.1 -0.2 1.0 -0.7 -0.2 0.7
Medication for cholesterol 0.5 0.8 2.4 -0.1 0.5 -1.5 -0.4 0.5 0.1 1.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 1.0 0.6 0.3 -1.0 0.9 -0.5 -0.4 0.2
Back pain experienced in last month 0.6 0.9 2.9 -0.6 -1.0 -1.1 -1.7 -0.4 0.2 0.7
Mineral and other dietary supplements 0.3 0.4 1.8 0.7 -0.3 -1.3 0.0 -0.3 0.0 0.2
Breast cancer (self-reported) 1.7 2.0 4.7 -1.6 -2.2 0.6 -0.1 -1.9 -1.6 -0.6
Asthma (self-reported) 2.4 4.7 9.4 2.4 2.8 -2.0 0.5 1.9 3.1 1.3
Osteoporosis (self-reported) 2.0 2.4 3.9 1.7 1.8 -1.7 0.1 1.8 2.0 1.1
Osteoarthritis (self-reported) 0.7 0.9 2.8 0.9 -0.2 0.6 1.7 -0.6 -0.1 -1.3
Medication: Aspirin 0.5 0.7 2.1 -0.1 0.3 -1.5 -1.0 0.8 0.7 0.5
Medication: Gliclazide 1.1 1.3 5.5 0.1 0.0 -2.3 1.4 -0.2 1.0 0.6
Illnesses of father: None of the above (group 1) 0.8 1.0 1.8 1.0 -1.1 -0.2 -1.4 -0.5 -0.8 -1.2
Smoking status: Current 1.2 1.8 4.8 0.4 1.9 -0.4 -0.5 2.2 1.5 1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.0 2.2 8.2 0.0 -0.6 2.9 0.9 -1.3 -0.9 -1.9
Whole body water mass 0.1 0.5 2.6 -0.9 0.2 -0.1 -1.6 -0.1 0.0 -0.6
Leg predicted mass (right) 0.4 2.2 6.5 -2.5 -1.3 -0.5 -1.9 -1.3 -1.2 -0.1
Arm fat mass (left) 0.1 0.6 1.5 -0.8 -0.9 -1.0 0.3 -0.5 -1.2 -0.2
Number of self-reported non-cancer illnesses 1.1 1.9 4.2 1.4 1.8 -1.7 -0.2 0.9 2.0 0.4
Average weekly champagne plus white wine intake 0.9 1.2 2.7 -1.0 -1.6 -1.0 -0.2 -1.4 -1.4 -0.3
Miserableness 1.1 1.9 4.7 2.0 2.2 -0.3 -0.8 1.3 1.5 0.0
Guilty feelings 0.3 0.4 1.7 -0.6 -0.4 -0.3 -1.3 -0.3 -0.8 -0.3
Wears glasses or contact lenses 0.3 0.3 0.8 0.3 0.8 -0.5 0.9 -0.3 0.5 0.2
Ever taken oral contraceptive pill 0.4 0.4 1.4 1.2 -0.1 -0.2 -0.7 0.3 0.9 0.3
Hearing aid user 0.3 0.4 1.7 0.0 -0.4 0.7 -0.4 -1.3 -0.5 0.1
Mother’s age at death 0.9 1.2 4.3 1.3 -0.5 -2.1 -1.1 0.5 0.1 -0.6
Financial situation satisfaction 1.2 1.5 3.0 1.7 1.4 -0.6 -0.4 1.5 1.5 0.3
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.7 -0.8 -0.1 0.0 0.0 -0.2 0.0 0.1
Commuting to job workplace: Public transport 1.0 1.2 2.9 1.2 1.7 -0.7 -0.3 1.4 1.1 -0.1
Eye problems/disorders: Glaucoma 1.7 2.0 3.3 1.2 1.8 -1.5 -0.3 1.5 1.8 1.2
Medication: Blood pressure 1.1 2.2 5.7 1.3 1.9 -1.2 1.2 1.0 2.4 0.5
Pain type(s) experienced in last month: Hip pain 0.3 0.3 1.2 0.2 -0.3 1.1 0.1 -0.1 -0.2 -1.0
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.3 -0.5 1.1 0.1 0.6 0.3 0.7 0.4
High cholesterol (Self-reported) 0.3 0.5 0.9 -1.0 -0.5 -0.7 -0.8 0.8 0.3 0.7
Medication: Bendroflumethiazide 3.0 4.6 7.6 1.1 2.7 -2.8 1.8 1.3 2.5 2.3
Medication: Paracetamol 0.2 0.3 0.5 0.5 0.7 -0.5 -0.4 0.6 0.5 -0.5
Medication: Lisinopril 0.6 0.8 2.0 -0.7 0.8 -0.7 1.4 1.1 0.9 0.2
Medication: Atorvastatin 1.4 1.8 5.5 0.5 1.7 1.0 0.9 1.0 2.3 1.1
Illnesses of father: High blood pressure 0.9 1.1 4.4 -0.5 0.7 -0.6 2.1 -1.5 -0.1 -0.2
Alcohol drinker status: Never 0.3 0.4 0.7 -0.8 -0.6 0.5 -0.5 -0.8 -0.8 0.2
Ever smoked 0.3 0.6 1.9 1.4 0.5 -0.3 -0.8 0.6 0.5 -0.7
Basal metabolic rate 0.1 0.5 1.8 -1.1 -0.1 -0.3 -1.3 -0.3 -0.4 -0.4
Leg fat percentage (left) 0.3 1.2 4.0 0.8 0.1 -1.8 2.0 -0.1 -0.7 -0.3
Arm fat-free mass (left) 0.1 0.3 0.9 -0.0 1.0 -0.5 -0.7 0.3 0.7 -0.3
Number of operations (self-reported) 0.3 0.4 1.3 -0.4 0.2 -0.4 1.1 -0.7 0.5 0.6
Average weekly beer plus cider intake 0.9 1.3 4.0 -1.4 -0.6 2.0 -0.6 0.2 -1.1 -0.9
Irritability 1.1 1.8 4.4 -0.3 2.1 -1.0 -1.4 1.9 1.2 0.0
Risk taking 0.4 0.6 1.4 0.6 1.0 0.6 1.2 0.2 0.7 -0.5
Ever had prostate specific antigen (PSA) test 0.5 0.6 1.3 -0.0 1.1 -0.2 -0.8 0.8 1.0 -0.5
Fractured/broken bones in last 5 years 1.9 2.4 5.0 1.6 1.8 -1.5 1.1 1.3 2.2 0.9
Age started oral contraceptive pill 0.4 0.5 3.0 1.7 0.0 -0.0 0.4 0.2 0.7 -0.1
Diastolic blood pressure, automated reading 1.3 4.1 11.2 -2.1 1.2 -3.3 0.1 -0.1 1.7 2.9
Ever depressed for a whole week 1.9 2.4 6.5 2.2 2.5 0.3 0.2 1.4 1.8 0.5
Unable to work because of sickness or disability 0.7 0.9 2.3 -1.2 -1.1 0.8 -0.4 -0.4 -1.5 -0.6
Commuting to job workplace: Cycle 0.5 0.6 3.5 -0.9 -0.1 1.9 0.0 -0.0 -0.3 -0.0
Myopia 1.0 1.4 2.2 -0.4 1.0 -1.5 -1.5 0.9 1.5 1.2
Vascular/heart problems diagnosed by doctor 1.4 3.9 8.7 -0.3 -1.9 2.8 -0.3 -1.7 -2.9 -2.1
Cholesterol lowering medication 0.4 0.6 1.2 0.1 -1.1 1.1 0.2 -0.3 -0.7 -1.0
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.8 -0.9 -0.3 0.2 -0.5 -0.0 -0.2 -0.5
Pain experienced in last month 0.3 0.4 1.5 0.0 -0.8 -0.6 1.2 -0.5 -0.5 -0.1
Supplements: Calcium 1.1 1.2 4.4 0.1 0.8 -0.2 -2.1 1.2 0.7 1.3
Basal cell carcinoma (self-reported) 1.8 2.1 4.3 -0.4 -0.8 1.8 0.1 -1.4 -2.1 -2.1
Heart attack/myocardial infarction (self-reported) 1.1 1.4 2.2 -0.8 -1.4 1.4 -1.5 -1.1 -0.8 -1.2
Deep venous thrombosis (DVT) (self-reported) 1.1 1.4 3.0 -0.4 -1.0 -0.1 1.3 -1.7 -1.1 -1.7
Heart disease (siblings) 0.2 0.3 1.0 -0.3 0.6 1.0 0.7 0.1 0.2 -0.3
Alcohol drinker status: Previous 0.4 0.4 0.9 0.6 0.5 -0.8 0.4 0.5 0.5 1.0
Pack years of smoking 1.6 2.4 5.2 1.4 1.8 -2.0 0.7 0.1 2.3 1.4
Impedance of whole body 0.1 0.8 2.7 0.5 -0.9 0.3 1.1 -0.4 -1.6 -0.3
Leg fat mass (left) 0.2 0.6 1.9 -0.0 -0.3 -1.4 0.9 -0.2 -1.1 -0.5
Arm predicted mass (left) 0.1 0.5 1.0 0.1 1.0 -0.8 -0.9 0.5 0.8 -0.2