TWAS hub - TIGD2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0940	0.0380	2.8e-03	0.001	0.018	0.007	0.023	0.002	0.220	2.5e-03	3.7e-02	0.00070	1.9e-01
2	GTEx	Stomach	0.1270	0.0570	6.0e-03	-0.005	NA	-0.005	NA	-0.003	0.630	NA	7.0e-01	NA	4.8e-01
3	GTEx	Testis	0.1850	0.0830	7.8e-03	-0.006	NA	0.007	NA	-0.006	0.900	NA	1.5e-01	NA	8.1e-01
4	ROSMAP	Brain Pre-frontal Cortex	0.0631	0.0211	6.7e-04	0.012	0.028	0.019	0.028	0.020	0.010	1.2e-04	1.5e-03	0.00012	1.1e-03
5	TCGA	Breast Invasive Carcinoma	0.0279	0.0137	4.5e-04	0.007	0.016	0.010	NA	0.009	0.012	2.1e-04	2.9e-03	NA	4.9e-03
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0608	0.0245	8.0e-07	0.012	0.066	0.073	NA	0.065	0.015	6.1e-08	1.3e-08	NA	8.5e-08
7	TCGA	Stomach Adenocarcinoma	0.0600	0.0310	3.8e-03	0.021	0.013	0.004	NA	0.013	0.011	3.9e-02	1.5e-01	NA	3.6e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Lung FEV1/FVC ratio	12.1	61.3	158.8	8.3	2.0	5.0	12.6	-2.6	-3.7	-12.3
Qualifications: NVQ or HND or HNC or equivalent	4.7	5.7	8.5	-1.5	-2.6	2.7	2.6	-2.6	-2.9	-1.2
Ever used hormone-replacement therapy (HRT)	3.6	4.6	7.7	2.6	2.8	-2.5	0.8	1.7	2.7	0.8
Friendships satisfaction	3.3	4.1	8.3	1.6	2.6	-0.5	-1.7	2.9	2.6	0.9
Medication: Bendroflumethiazide	3.0	4.6	7.6	1.1	2.7	-2.8	1.8	1.3	2.5	2.3
Respiratory disease	2.8	6.2	11.7	3.4	3.2	-1.3	0.2	3.2	2.9	1.0
Birth weight	2.8	6.1	11.6	-1.4	-2.4	2.0	-2.0	-2.9	-2.5	-3.4
Pulse rate, automated reading	2.5	8.2	14.6	1.1	3.4	-3.8	0.1	2.8	3.8	2.8
Asthma (self-reported)	2.4	4.7	9.4	2.4	2.8	-2.0	0.5	1.9	3.1	1.3
Maternal smoking around birth	2.3	3.4	6.1	1.7	2.4	-1.5	-0.6	2.0	2.5	1.5
Pulse rate	2.3	3.9	8.0	1.0	2.8	-2.4	0.2	1.6	2.5	2.0
Asthma	2.3	4.6	10.0	2.2	2.9	-1.6	0.1	2.2	3.2	1.4
Glaucoma (self-reported)	2.3	2.7	6.5	1.2	2.2	-1.1	0.2	1.5	2.5	1.6
Medication: Ventolin 100micrograms inhaler	2.3	2.9	6.2	0.7	2.5	-2.0	0.9	0.8	2.3	1.8
Reaction Time	2.2	4.2	11.1	-1.7	2.0	-2.4	1.6	0.6	1.5	3.3
Lung FVC	2.2	11.2	44.0	-4.3	-0.1	0.7	-6.6	0.7	1.6	3.6
Average weekly fortified wine intake	2.2	2.6	5.5	-2.3	-2.0	1.0	-1.1	-2.3	-1.3	0.1
Illnesses of siblings	2.2	3.1	7.0	0.3	-1.4	2.6	-0.3	-1.7	-2.1	-2.4
Illnesses of mother	2.2	2.7	8.0	-0.9	-1.2	2.8	0.7	-2.0	-1.5	-1.3
Loud music exposure frequency	2.1	2.3	7.2	0.5	1.8	-2.7	1.2	0.8	1.4	1.1
Neck or shoulder pain in last month	2.1	2.9	5.8	2.4	2.1	1.5	-0.7	1.7	2.0	-1.0
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.2	7.6	2.2	2.8	-0.5	-0.7	2.0	2.2	0.5
Osteoporosis (self-reported)	2.0	2.4	3.9	1.7	1.8	-1.7	0.1	1.8	2.0	1.1
Neuroticism	1.9	4.6	11.0	1.3	3.3	-1.5	-2.4	2.0	2.6	0.6
Medication: Metformin	1.9	2.6	6.3	1.8	1.1	-2.3	2.5	0.7	1.4	0.1
High blood pressure	1.9	5.3	10.7	0.8	2.5	-3.2	0.5	2.3	3.3	2.1
Chronic bronchitis/emphysema (father)	1.9	2.2	8.7	-0.9	0.9	-0.7	-0.8	1.8	0.9	2.9
Wheeze or whistling in the chest in last year	1.9	3.3	6.5	0.2	2.1	-2.2	0.0	1.2	2.5	2.5
Fractured/broken bones in last 5 years	1.9	2.4	5.0	1.6	1.8	-1.5	1.1	1.3	2.2	0.9
Ever depressed for a whole week	1.9	2.4	6.5	2.2	2.5	0.3	0.2	1.4	1.8	0.5
Chronotype (morning person)	1.8	4.2	13.0	1.7	0.3	-3.1	3.6	-0.5	0.4	1.6
Mean time to correctly identify matches	1.8	3.4	9.0	-1.2	1.2	-3.0	1.9	-0.2	1.1	2.7
Basal cell carcinoma (self-reported)	1.8	2.1	4.3	-0.4	-0.8	1.8	0.1	-1.4	-2.1	-2.1
High blood pressure (mother)	1.7	2.3	8.8	0.2	0.9	-3.0	0.3	0.6	1.3	2.1
Noisy workplace	1.7	2.0	8.2	1.9	0.8	0.0	2.9	0.0	-0.8	-1.1
High blood pressure (siblings)	1.7	2.5	5.2	-0.1	1.7	-2.3	0.4	1.4	2.0	1.8
Breast cancer (self-reported)	1.7	2.0	4.7	-1.6	-2.2	0.6	-0.1	-1.9	-1.6	-0.6
Eye problems/disorders: Glaucoma	1.7	2.0	3.3	1.2	1.8	-1.5	-0.3	1.5	1.8	1.2
Hypertension (Self-reported)	1.6	4.5	9.3	0.4	2.2	-3.0	0.7	2.0	2.9	2.2
Pack years of smoking	1.6	2.4	5.2	1.4	1.8	-2.0	0.7	0.1	2.3	1.4
Lupus	1.5	2.3	8.8	-1.6	-1.5	1.2	-3.0	-1.0	-0.1	0.2
Pack years adult smoking proportion	1.5	2.3	4.2	1.3	1.8	-1.9	1.0	0.2	2.0	1.5
Prospective memory result	1.5	1.8	3.3	0.5	-1.3	-0.7	1.8	-1.4	-1.4	-1.8
Peak expiratory flow (PEF)	1.5	3.5	11.8	1.0	-0.7	3.4	1.8	-0.9	-1.0	-2.6
Forced vital capacity (FVC), Best measure	1.5	5.7	18.4	-3.5	-1.3	2.3	-4.3	-0.5	-0.6	1.3
Medication: Co-codamol	1.4	1.6	2.2	-1.1	1.4	-1.4	-1.4	0.4	1.3	1.5
Fed-up feelings	1.4	2.6	6.1	1.3	2.5	-1.6	-0.7	1.4	2.3	0.6
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	3.2	1.6	0.6	1.8	0.4	1.1	-0.1	-1.8
Financial difficulties in last 2 years	1.4	1.9	3.2	-0.0	1.8	-1.6	-1.5	0.9	1.5	1.5
Happiness	1.4	1.7	4.2	1.9	1.2	0.6	-1.3	2.0	0.8	-0.4
Illnesses of siblings: Diabetes	1.4	1.7	6.5	0.5	-0.7	-2.6	1.9	-0.4	-0.1	0.8
Medication: Atorvastatin	1.4	1.8	5.5	0.5	1.7	1.0	0.9	1.0	2.3	1.1
Vascular/heart problems diagnosed by doctor	1.4	3.9	8.7	-0.3	-1.9	2.8	-0.3	-1.7	-2.9	-2.1
Systolic Blood Pressure	1.3	6.4	14.7	0.4	2.8	-3.8	-1.5	1.7	3.7	1.9
Ever had hysterectomy (womb removed)	1.3	1.5	5.0	1.3	-0.2	-0.6	2.2	-0.2	-1.2	-1.4
Hair/balding pattern: Pattern 4	1.3	3.1	7.1	-1.1	-1.9	1.4	1.2	-1.6	-2.7	-1.8
Medication: Amlodipine	1.3	1.8	10.0	-0.5	0.6	-3.2	0.2	0.5	1.1	0.6
Diastolic blood pressure, automated reading	1.3	4.1	11.2	-2.1	1.2	-3.3	0.1	-0.1	1.7	2.9
Crohns Disease (2017)	1.2	2.7	8.4	2.1	0.4	-2.2	2.9	-0.7	0.2	0.7
Mean Putamen Volume	1.2	1.4	3.8	0.7	1.5	1.5	-0.6	1.9	0.8	-0.1
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	3.5	1.9	1.6	0.6	-0.5	1.6	0.9	-0.4
Allergy	1.2	2.8	6.4	-2.5	-2.5	0.7	-0.8	-1.5	-1.7	-0.6
Number of live births	1.2	1.8	3.7	0.8	-0.8	1.3	1.9	-0.5	-1.4	-1.9
Medication: Blood pressure	1.2	2.1	11.1	-0.2	0.8	-3.3	0.6	0.9	1.1	0.9
Smoking status: Current	1.2	1.8	4.8	0.4	1.9	-0.4	-0.5	2.2	1.5	1.2
Financial situation satisfaction	1.2	1.5	3.0	1.7	1.4	-0.6	-0.4	1.5	1.5	0.3
Neuroticism (Nagel 2018)	1.1	2.5	6.7	0.9	2.6	-0.7	-2.2	1.3	1.7	0.2
Crohns Disease (2012)	1.1	1.8	4.4	2.1	0.1	-2.0	1.8	-0.7	0.3	0.5
Neuroticism (2016)	1.1	1.6	3.2	-0.6	-1.6	-0.5	-0.6	-1.8	-1.2	-1.7
Blood Eosinophil Count	1.1	8.4	31.4	-0.0	1.4	-5.6	0.2	1.7	3.0	3.6
Blood White Count	1.1	7.9	22.2	-0.9	2.0	-3.0	-0.9	2.8	3.3	4.7
Waist Hip Ratio (WHR)	1.1	5.0	13.0	1.2	3.1	-0.4	-1.9	1.9	3.6	1.9
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	6.4	-1.1	-0.9	0.7	-0.7	-2.5	-0.6	-0.3
Medication: Atenolol	1.1	1.3	3.6	-1.9	-1.3	0.5	-1.5	-1.0	-0.8	-0.3
Neuroticism score	1.1	2.4	6.9	0.8	2.6	-1.4	-1.4	1.4	1.7	0.8
Birth weight of first child	1.1	2.1	7.3	0.8	0.2	2.1	1.2	-0.6	-0.4	-2.7
Pulse wave reflection index	1.1	1.4	4.8	-1.2	-0.7	0.2	1.1	-2.2	-1.3	0.1
Medication for cholesterol, blood pressure or diabetes	1.1	1.9	7.3	1.0	-0.8	2.7	0.3	-1.1	-1.2	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	3.1	0.7	1.8	-0.8	1.4	1.5	1.2	0.7
Number of children fathered	1.1	1.2	3.9	0.4	-0.1	2.0	0.7	-0.1	-1.1	-1.7
Shortness of breath walking on level ground	1.1	1.3	2.1	-0.5	0.3	-1.5	-1.4	1.4	0.8	1.4
Medication: Gliclazide	1.1	1.3	5.5	0.1	0.0	-2.3	1.4	-0.2	1.0	0.6
Number of self-reported non-cancer illnesses	1.1	1.9	4.2	1.4	1.8	-1.7	-0.2	0.9	2.0	0.4
Miserableness	1.1	1.9	4.7	2.0	2.2	-0.3	-0.8	1.3	1.5	0.0
Medication: Blood pressure	1.1	2.2	5.7	1.3	1.9	-1.2	1.2	1.0	2.4	0.5
Irritability	1.1	1.8	4.4	-0.3	2.1	-1.0	-1.4	1.9	1.2	0.0
Supplements: Calcium	1.1	1.2	4.4	0.1	0.8	-0.2	-2.1	1.2	0.7	1.3
Heart attack/myocardial infarction (self-reported)	1.1	1.4	2.2	-0.8	-1.4	1.4	-1.5	-1.1	-0.8	-1.2
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	3.0	-0.4	-1.0	-0.1	1.3	-1.7	-1.1	-1.7
Worry (Nagel 2018)	1.0	2.2	5.0	1.1	2.0	-0.9	-2.2	1.0	1.6	0.7
Irritable Bowel Disease (IBD)	1.0	2.3	8.8	1.6	0.2	-2.0	3.0	0.5	-0.1	0.6
Type 2 Diabetes (T2D) (2012)	1.0	1.1	2.5	1.6	1.1	0.0	1.3	1.1	1.1	-0.4
Cardiovascular Disease	1.0	3.4	7.6	-1.9	1.0	-2.6	-0.6	1.0	1.8	2.8
Supplements: Zinc	1.0	1.1	2.2	-1.5	-0.5	1.2	-1.4	-1.1	-0.8	-0.4
Current tobacco smoking	1.0	1.6	4.3	0.8	2.0	-0.3	0.0	2.1	1.4	0.8
Forced vital capacity (FVC)	1.0	3.9	14.6	-2.7	-1.0	1.4	-3.8	0.0	0.1	1.6
Pain all over the body in last month	1.0	1.0	3.6	1.3	1.0	-0.7	1.9	0.6	0.2	-0.3
Medication: Cholesterol lowering	1.0	1.5	2.7	-0.7	1.0	-1.5	-0.6	1.4	1.5	1.6
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	3.4	-1.8	-1.3	0.1	-1.1	-1.4	-0.6	-0.6
Exposure to tobacco smoke outside home	1.0	1.4	3.5	1.0	1.9	-0.7	-0.5	1.4	1.6	0.1
Worry too long after embarrassment	1.0	1.7	3.9	0.3	2.0	-0.9	-1.2	0.7	1.9	1.2
Qualifications: College or University degree	1.0	3.2	19.1	-1.1	0.3	0.9	-4.4	0.2	1.0	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.2	8.2	0.0	-0.6	2.9	0.9	-1.3	-0.9	-1.9
Commuting to job workplace: Public transport	1.0	1.2	2.9	1.2	1.7	-0.7	-0.3	1.4	1.1	-0.1
Myopia	1.0	1.4	2.2	-0.4	1.0	-1.5	-1.5	0.9	1.5	1.2
Bipolar Disorder or Schizophrenia	0.9	2.2	3.6	0.4	1.7	-1.9	-0.9	1.7	1.6	1.6
Depressed Affect (Nagel 2018)	0.9	1.9	5.1	1.6	2.3	-0.0	-1.2	1.5	1.4	-0.3
Schizophrenia (2014)	0.9	1.9	3.8	0.6	1.6	-1.7	-1.0	2.0	1.3	1.1
Systolic blood pressure, automated reading	0.9	2.6	11.6	-0.1	1.2	-3.4	-0.2	0.3	1.9	1.2
Vitamin and mineral supplements	0.9	1.3	3.3	0.7	-1.1	-1.8	1.8	-0.6	-0.5	0.4
Stomach or abdominal pain in last month	0.9	1.2	3.1	1.7	1.8	-0.4	0.4	-0.0	1.4	0.1
Hayfever/allergic rhinitis (self-reported)	0.9	1.1	4.2	0.6	-0.3	0.6	0.4	-0.3	-1.6	-2.1
Medication: Ramipril	0.9	1.1	2.7	0.0	1.4	-1.7	0.1	0.2	1.6	0.7
Hair/balding pattern: Pattern 3	0.9	1.3	4.5	-0.5	-0.3	-1.4	2.1	-1.2	0.0	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.8	11.2	-1.1	-0.8	3.4	-0.7	-0.9	-1.4	-1.8
Medication: Ibuprofen	0.9	1.1	2.8	-1.7	-1.2	0.5	-0.7	-1.4	-0.9	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	3.2	-0.4	-1.2	0.4	-0.3	-1.8	-1.1	-1.2
Commuting to job workplace: Walk	0.9	0.9	2.3	-0.2	1.1	1.5	-0.8	1.3	0.5	-0.8
Average weekly champagne plus white wine intake	0.9	1.2	2.7	-1.0	-1.6	-1.0	-0.2	-1.4	-1.4	-0.3
Mother’s age at death	0.9	1.2	4.3	1.3	-0.5	-2.1	-1.1	0.5	0.1	-0.6
Illnesses of father: High blood pressure	0.9	1.1	4.4	-0.5	0.7	-0.6	2.1	-1.5	-0.1	-0.2
Average weekly beer plus cider intake	0.9	1.3	4.0	-1.4	-0.6	2.0	-0.6	0.2	-1.1	-0.9
Bipolar Disorder (2018)	0.8	1.3	3.9	0.1	1.1	-1.0	0.1	0.3	1.7	2.0
Schizophrenia vs Biploar Disorder	0.8	1.1	2.1	1.3	0.1	-0.4	-1.0	1.5	-0.8	-1.4
Ulcerative Colitis (UC)	0.8	1.5	4.9	0.7	0.1	-1.4	2.2	1.7	-0.2	0.6
Ovarian Cancer	0.8	1.0	2.1	1.0	-1.2	0.5	-0.9	-1.4	-0.1	-1.2
Medication for hormone replacement therapy	0.8	0.9	2.6	-1.1	-0.6	1.6	-1.4	-0.2	-0.4	-0.0
Townsend deprivation index at recruitment	0.8	1.2	2.1	1.5	1.3	-1.4	1.1	0.8	0.5	0.5
Multivitamins +/- minerals	0.8	1.0	2.9	-1.7	0.3	1.6	-1.0	-0.7	-0.0	-0.1
Heart attack	0.8	1.0	1.7	-0.7	-1.1	1.2	-1.3	-0.6	-0.7	-1.1
Fluid intelligence score	0.8	1.7	3.7	-0.4	0.3	1.9	-1.9	0.7	1.0	1.8
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.2	-0.6	-1.0	-0.6	-0.5	-1.1	-1.1	-1.5
Medication: Lansoprazole	0.8	0.9	4.0	-1.0	-1.0	2.0	-0.4	-0.4	-0.3	0.0
Lung cancer (father)	0.8	1.0	2.5	1.6	1.2	-0.4	0.2	1.2	1.1	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.3	3.1	0.2	1.8	-0.7	1.0	1.7	1.0	0.7
Gout (self-reported)	0.8	1.1	4.5	-0.4	-0.6	-2.1	-0.1	-0.2	0.4	1.5
Medication: Allopurinol	0.8	1.0	4.1	-0.6	-0.3	-2.0	0.5	-0.2	0.3	1.5
Family relationship satisfaction	0.8	1.0	2.2	1.5	0.9	-1.2	-0.7	1.0	1.0	0.3
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.7	-1.1	-1.3	-0.3	0.7	-1.2	-1.2	-0.1
Illnesses of father: Heart disease	0.8	1.1	5.9	0.7	1.0	-0.2	2.4	0.4	0.2	-0.5
Ever had bowel cancer screening	0.8	1.0	3.4	1.0	0.2	-1.8	0.4	-0.7	0.1	-1.4
Illnesses of father: None of the above (group 1)	0.8	1.0	1.8	1.0	-1.1	-0.2	-1.4	-0.5	-0.8	-1.2
Schizophrenia (2018)	0.7	1.5	3.8	0.5	1.3	-1.6	-1.2	2.0	0.7	0.5
Blood Red Count	0.7	7.1	18.2	-0.0	-0.2	-3.8	4.3	-0.6	0.7	4.0
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	2.5	0.4	-1.1	0.6	0.0	-1.6	-0.3	-1.1
Diabetes (mother)	0.7	0.9	2.7	0.5	0.3	-1.1	-1.3	1.6	0.7	0.3
Number of incorrect matches in round	0.7	1.2	2.2	1.5	1.1	-1.4	1.1	0.2	1.4	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.2	2.5	1.1	1.4	-1.6	-0.6	0.1	1.2	0.8
Diabetes (self-reported)	0.7	1.1	4.0	0.9	-0.7	-1.3	2.0	-0.1	0.4	-0.9
Father’s age at death	0.7	1.0	2.8	-0.2	1.1	1.0	-1.7	0.5	1.2	-0.4
Impedance of arm (left)	0.7	3.2	10.1	-1.4	-2.7	0.5	0.0	-1.5	-3.2	-0.7
Medication: Seretide 50 evohaler	0.7	0.8	2.3	0.8	-0.2	-1.5	1.0	0.8	0.9	0.1
Heart disease (mother)	0.7	0.8	3.0	1.2	0.6	0.2	1.7	0.4	0.1	-0.7
Number of full sisters	0.7	0.8	2.3	1.5	1.0	-0.3	-0.1	1.1	0.3	0.9
Suffer from ‘nerves’	0.7	1.1	2.8	-1.0	0.5	-1.7	-1.3	-1.0	0.5	0.9
Chest pain or discomfort	0.7	1.0	2.4	0.5	1.3	-0.9	-0.5	0.8	1.6	1.1
Leg pain on walking	0.7	0.8	2.0	1.3	-0.0	0.3	1.4	0.1	-0.4	-1.4
Loneliness, isolation	0.7	0.9	2.1	0.7	1.4	-0.5	-1.3	1.2	0.5	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.9	-1.2	0.7	-0.7	-0.5	0.3	1.4	0.9
Osteoarthritis (self-reported)	0.7	0.9	2.8	0.9	-0.2	0.6	1.7	-0.6	-0.1	-1.3
Unable to work because of sickness or disability	0.7	0.9	2.3	-1.2	-1.1	0.8	-0.4	-0.4	-1.5	-0.6
Alzheimer’s Disease (in mother)	0.6	0.8	1.7	-0.8	0.4	-0.7	-0.9	0.9	1.3	0.9
Major Depression (MDD)	0.6	0.7	2.4	-0.8	0.6	-0.5	1.1	0.4	0.1	1.5
Prostate Cancer	0.6	0.8	4.3	-0.3	0.1	0.4	-2.1	0.7	0.9	-0.3
Bipolar Disorder (2011)	0.6	0.6	2.4	-0.1	0.3	0.1	0.2	0.5	1.5	1.2
Coronary Artery Disease (CAD)	0.6	0.7	1.6	1.0	0.7	-1.3	-1.0	0.4	0.7	0.3
Triglycerides	0.6	1.1	4.2	-0.1	-0.4	-1.3	0.5	-0.6	0.9	2.0
Impedance of leg (right)	0.6	3.0	10.2	3.2	1.6	0.5	2.1	1.8	0.4	-0.4
Hand grip strength (right)	0.6	1.5	3.8	1.1	1.5	1.9	-0.6	1.7	0.6	0.3
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.2	0.6	1.5	-0.2	0.4	0.6	1.3	0.2
Qualifications: CSEs or equivalent	0.6	0.8	2.4	-0.5	-1.1	-0.6	0.1	-1.0	-1.6	0.4
Serious illness, injury or assault to yourself	0.6	0.7	1.2	-0.5	-0.3	1.1	-0.9	-1.0	-0.8	-1.0
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.5	-0.1	-0.4	-1.6	0.3	-1.5	0.1	0.7
Medication: Levothyroxine sodium	0.6	1.1	2.2	-0.8	-0.9	1.1	1.5	-1.2	-0.9	-0.7
Past tobacco smoking	0.6	1.1	2.3	-1.5	-0.3	1.1	1.5	-0.7	-0.8	0.5
Medication: Simvastatin	0.6	0.9	2.6	-0.9	-0.5	-1.6	-0.8	0.2	0.7	1.2
Time employed in main current job	0.6	0.7	1.7	-0.3	-1.2	-0.3	-0.9	-0.5	-1.3	-0.5
Mouth/teeth dental problems: Dentures	0.6	1.0	2.2	1.1	-0.6	-1.5	1.2	-1.0	-0.5	0.0
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	3.0	-1.7	-0.7	0.1	-0.2	-1.0	-0.7	0.8
Breastfed as a baby	0.6	0.8	2.1	-0.9	-0.4	1.0	1.1	-1.4	-0.1	-0.1
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.4	0.1	0.7	1.2	-1.1	1.1	0.3	0.5
Eye problems/disorders: None of the above	0.6	0.7	1.5	-0.0	-1.2	0.5	0.1	-0.8	-1.1	-1.0
Emphysema/chronic bronchitis	0.6	0.7	2.6	0.5	0.1	0.3	-0.9	0.3	0.9	1.6
Diabetes diagnosed by doctor	0.6	0.9	2.9	0.9	-0.5	-1.3	1.7	-0.2	0.6	-0.9
Back pain experienced in last month	0.6	0.9	2.9	-0.6	-1.0	-1.1	-1.7	-0.4	0.2	0.7
Medication: Lisinopril	0.6	0.8	2.0	-0.7	0.8	-0.7	1.4	1.1	0.9	0.2
Depression (Nagel 2018)	0.5	0.7	3.1	0.3	1.8	0.5	0.1	0.7	0.8	-0.4
Breast Cancer	0.5	1.1	3.8	-0.2	0.0	-0.8	-1.1	0.6	2.0	1.3
Ulcerative Colitis	0.5	0.7	1.3	-1.1	-0.9	-0.6	-0.5	0.6	-0.7	1.0
Blood Platelet Count	0.5	5.6	24.1	-2.3	0.1	0.7	-4.9	1.6	1.0	2.4
Type 2 Diabetes (T2D) (2018)	0.5	1.0	2.3	1.5	0.0	-1.2	1.4	0.4	0.7	-0.8
Hand grip strength (left)	0.5	1.2	3.1	0.7	1.8	1.5	-0.5	1.3	0.6	0.0
Hearing difficulty/problems: Yes	0.5	0.8	2.7	-0.8	0.7	1.6	0.9	-0.3	0.6	0.4
Relative age of first facial hair	0.5	1.1	4.7	2.2	1.0	-0.7	0.1	0.6	1.1	-0.2
Severe depression (siblings)	0.5	0.6	1.9	-0.4	-0.7	1.1	-1.4	-0.3	-0.1	-0.5
Trunk fat percentage	0.5	2.0	4.1	-1.2	-1.6	-1.9	1.1	-0.7	-2.0	0.3
Hayfever, allergic rhinitis or eczema	0.5	1.1	4.2	2.1	1.3	0.5	0.8	0.6	0.1	-0.7
Supplements: Glucosamine	0.5	0.6	1.4	-0.4	-1.1	1.2	0.2	-1.0	-0.6	-0.6
Nervous feelings	0.5	1.0	1.8	1.1	1.3	-1.3	-0.8	0.7	0.8	0.6
Hair/balding pattern: Pattern 2	0.5	0.6	3.2	0.1	0.5	0.0	-1.8	0.3	0.9	-0.3
Had menopause	0.5	0.6	2.1	0.8	1.0	-0.6	-0.0	0.2	1.5	0.5
Had other major operations	0.5	0.6	2.0	0.9	0.1	0.6	1.4	-0.8	-0.1	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	2.5	-0.7	1.6	0.8	0.6	1.4	1.5	0.3
Qualifications: None of the above	0.5	1.0	4.5	1.0	-0.3	-0.5	2.1	-0.4	-1.0	-0.5
Falls in the last year	0.5	0.7	3.5	0.1	0.7	-0.3	1.9	-0.9	0.1	0.4
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	8.0	-0.6	-0.5	2.8	-0.3	-0.6	-0.6	-1.4
Length of working week for main job	0.5	0.6	2.5	-0.4	0.4	-0.3	1.6	-0.7	-0.4	0.6
Exposure to tobacco smoke at home	0.5	0.5	1.8	-0.1	0.3	0.3	-1.4	-0.3	0.8	1.1
Blood clot in the leg (DVT)	0.5	0.6	1.5	-0.1	-0.5	-0.7	0.9	-1.1	-0.3	-1.2
Comparative body size at age 10	0.5	1.3	4.0	-2.0	-0.1	0.6	-1.2	-0.6	0.5	1.7
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.2	-0.8	0.2	-1.0	-0.7	-0.5	0.3	1.1
Age at first live birth	0.5	0.9	2.8	-0.8	0.2	-0.1	-1.7	0.5	1.3	0.9
Pulse wave peak to peak time	0.5	0.6	1.8	0.6	-0.1	0.2	-1.0	1.3	0.2	-1.0
Migraine (self-reported)	0.5	0.6	1.6	0.8	1.3	0.7	0.7	0.8	0.4	0.7
Medication: Aspirin	0.5	0.7	1.4	0.0	0.5	-1.2	-1.1	1.0	0.9	0.5
Knee pain experienced in last month	0.5	0.8	4.2	0.0	0.4	0.9	-2.1	-0.6	0.4	-0.3
Arm fat percentage (left)	0.5	2.2	5.9	-1.2	-2.0	-1.2	0.9	-1.1	-2.4	-0.3
Medication for cholesterol	0.5	0.8	2.4	-0.1	0.5	-1.5	-0.4	0.5	0.1	1.6
Medication: Aspirin	0.5	0.7	2.1	-0.1	0.3	-1.5	-1.0	0.8	0.7	0.5
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.3	-0.0	1.1	-0.2	-0.8	0.8	1.0	-0.5
Commuting to job workplace: Cycle	0.5	0.6	3.5	-0.9	-0.1	1.9	0.0	-0.0	-0.3	-0.0
Age at First Birth	0.4	0.5	1.5	1.1	0.5	-0.2	1.2	-0.2	0.7	0.1
HbA1C	0.4	0.4	2.0	1.4	-0.1	0.7	0.6	-0.3	-0.1	-0.5
Primary Biliary Cirrhosis	0.4	0.5	1.3	-0.0	-0.2	-0.7	1.0	-1.2	-0.8	-0.1
Rheumatoid Arthritis	0.4	0.5	1.2	-0.7	0.9	0.3	-1.1	0.4	0.3	0.8
Heel T-Score	0.4	3.4	8.6	-0.1	2.9	0.6	0.2	2.4	1.8	2.3
Frequency of depressed mood in last 2 weeks	0.4	0.5	2.3	0.2	1.5	-0.5	0.1	0.6	0.6	-0.4
Angina	0.4	0.5	1.4	-1.0	-1.2	0.6	-0.4	0.6	-0.6	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.8	0.8	1.4	-0.0	0.8	0.1	0.6	-0.3
Age when periods started (menarche)	0.4	0.9	3.9	-0.3	0.4	2.0	-1.4	0.1	0.4	-0.5
Impedance of leg (left)	0.4	2.0	7.7	2.8	1.5	0.3	1.7	1.1	0.2	-0.3
Alcohol usually taken with meals	0.4	0.6	2.0	-0.5	-1.4	0.5	0.3	-1.0	-1.0	-0.1
Hearing difficulty/problems with background noise	0.4	0.6	2.5	-0.4	-0.8	-0.0	1.6	-0.8	-0.1	-0.8
Arm fat percentage (right)	0.4	1.6	4.3	-0.6	-1.5	-1.4	1.3	-0.9	-2.1	-0.5
Hip circumference	0.4	1.6	4.0	-1.1	-1.7	-0.6	0.0	-1.4	-2.0	-0.7
Pulse wave Arterial Stiffness index	0.4	0.5	1.6	-0.6	0.1	-0.1	0.9	-1.3	-0.3	0.9
Tense / ‘highly strung’	0.4	0.6	1.4	1.2	1.2	-0.5	-0.5	-0.5	0.7	-0.5
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.2	0.3	0.4	-0.6	-0.3	0.8	1.1	1.0
Body fat percentage	0.4	1.7	4.6	-0.5	-1.4	-1.6	1.4	-0.6	-2.1	-0.3
Leg fat percentage (right)	0.4	1.4	4.8	1.2	0.3	-1.6	2.2	0.5	-0.5	-0.4
Number of full brothers	0.4	0.6	1.1	0.6	0.8	0.2	1.1	0.8	0.9	0.6
Angina (self-reported)	0.4	0.5	1.6	-0.8	-1.2	0.5	-0.3	0.7	-0.7	-0.2
Medication: Omeprazole	0.4	0.4	1.0	-1.0	0.3	0.0	-1.0	0.7	0.5	0.2
Comparative height size at age 10	0.4	2.3	4.5	-2.1	-1.7	0.5	-1.6	-1.3	-1.5	-1.4
Had major operations	0.4	0.4	1.8	-1.3	-0.0	0.6	-0.3	0.1	-0.0	0.9
Smoking status: Previous	0.4	0.6	1.2	1.1	-0.8	-0.6	-0.6	-0.4	0.1	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.7	-1.3	-0.8	0.6	-1.0	-0.5	-1.3	0.4
Leg fat-free mass (right)	0.4	2.0	5.8	-2.4	-1.3	-0.5	-1.9	-1.2	-1.2	-0.1
Eye problems/disorders: Cataract	0.4	0.4	1.5	0.4	0.8	-1.2	0.1	0.7	0.4	-0.3
Leg predicted mass (right)	0.4	2.2	6.5	-2.5	-1.3	-0.5	-1.9	-1.3	-1.2	-0.1
Ever taken oral contraceptive pill	0.4	0.4	1.4	1.2	-0.1	-0.2	-0.7	0.3	0.9	0.3
Risk taking	0.4	0.6	1.4	0.6	1.0	0.6	1.2	0.2	0.7	-0.5
Age started oral contraceptive pill	0.4	0.5	3.0	1.7	0.0	-0.0	0.4	0.2	0.7	-0.1
Cholesterol lowering medication	0.4	0.6	1.2	0.1	-1.1	1.1	0.2	-0.3	-0.7	-1.0
Alcohol drinker status: Previous	0.4	0.4	0.9	0.6	0.5	-0.8	0.4	0.5	0.5	1.0
Alzheimer’s Disease (including proxy)	0.3	0.4	1.1	0.0	0.3	-1.1	-0.2	0.4	1.0	0.6
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.8	-1.1	-0.6	1.4	-1.0	-0.6	0.1	1.1
HDL Cholesterol	0.3	0.6	1.5	-1.2	-1.0	0.5	0.2	-0.6	-0.9	-0.0
Sensitivity / hurt feelings	0.3	0.5	1.9	0.3	0.9	-0.7	-1.4	0.3	-0.1	0.2
Leg fat-free mass (left)	0.3	1.5	4.5	-2.1	-1.2	-0.4	-1.7	-0.8	-1.1	-0.2
Taking other prescription medications	0.3	0.4	1.0	0.8	1.0	-0.3	0.4	-0.3	0.9	0.0
Leg predicted mass (left)	0.3	1.5	4.5	-2.1	-1.2	-0.4	-1.6	-0.8	-1.1	-0.2
Trunk fat mass	0.3	1.3	3.3	-1.1	-1.2	-1.8	0.6	-0.5	-1.7	0.1
Mouth/teeth dental problems	0.3	0.5	1.7	-0.3	0.8	0.9	-0.2	1.3	0.4	0.1
Impedance of arm (right)	0.3	1.4	5.6	0.1	-1.4	0.1	0.9	-0.6	-2.4	-0.8
Alcohol intake versus 10 years previously	0.3	0.4	1.4	-0.8	0.1	-0.7	-1.2	0.4	0.2	0.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.1	0.2	-0.9	0.1	1.0	-0.2	-1.0	-0.8
Headache pain in last month	0.3	0.5	1.3	-0.0	1.0	1.2	-0.7	0.6	0.1	0.5
Health satisfaction	0.3	0.4	1.1	0.6	0.7	0.1	-1.1	0.5	0.5	-0.0
Mouth/teeth dental problems: Loose teeth	0.3	0.3	1.1	-0.2	-0.2	-0.8	-0.7	1.0	0.0	0.4
Medication for pain relief, constipation, heartburn	0.3	0.6	2.0	1.4	0.6	0.6	0.7	0.5	0.6	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.9	0.3	-0.7	-0.4	0.9	-0.5	-0.7	0.0
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.7	0.4	0.8	0.2	-0.5	0.8	0.8	-0.0
Qualifications: nursing, teaching	0.3	0.4	2.2	-0.6	0.3	-0.4	-0.2	-0.0	0.6	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.0	0.6	0.3	-1.0	0.9	-0.5	-0.4	0.2
Mineral and other dietary supplements	0.3	0.4	1.8	0.7	-0.3	-1.3	0.0	-0.3	0.0	0.2
Guilty feelings	0.3	0.4	1.7	-0.6	-0.4	-0.3	-1.3	-0.3	-0.8	-0.3
Wears glasses or contact lenses	0.3	0.3	0.8	0.3	0.8	-0.5	0.9	-0.3	0.5	0.2
Hearing aid user	0.3	0.4	1.7	0.0	-0.4	0.7	-0.4	-1.3	-0.5	0.1
Pain type(s) experienced in last month: Hip pain	0.3	0.3	1.2	0.2	-0.3	1.1	0.1	-0.1	-0.2	-1.0
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.3	-0.5	1.1	0.1	0.6	0.3	0.7	0.4
High cholesterol (Self-reported)	0.3	0.5	0.9	-1.0	-0.5	-0.7	-0.8	0.8	0.3	0.7
Alcohol drinker status: Never	0.3	0.4	0.7	-0.8	-0.6	0.5	-0.5	-0.8	-0.8	0.2
Ever smoked	0.3	0.6	1.9	1.4	0.5	-0.3	-0.8	0.6	0.5	-0.7
Leg fat percentage (left)	0.3	1.2	4.0	0.8	0.1	-1.8	2.0	-0.1	-0.7	-0.3
Number of operations (self-reported)	0.3	0.4	1.3	-0.4	0.2	-0.4	1.1	-0.7	0.5	0.6
Pain experienced in last month	0.3	0.4	1.5	0.0	-0.8	-0.6	1.2	-0.5	-0.5	-0.1
Intelligence (Savage-Jansen 2018)	0.2	0.8	2.9	-0.7	-0.1	1.7	-1.3	-0.0	0.2	0.5
Alzheimer’s Disease (in father)	0.2	0.2	0.5	0.6	0.7	-0.1	-0.3	0.1	0.2	-0.6
Body Mass Index (BMI) (2010)	0.2	0.2	0.7	0.8	0.2	0.2	-0.2	0.8	-0.1	0.3
BMI	0.2	1.1	2.8	-1.7	-1.2	-1.0	0.3	-0.7	-1.0	0.9
Hypothyroidism (self reported)	0.2	0.4	2.1	0.7	-0.1	0.2	1.4	0.5	-0.1	0.4
Diabetes (father)	0.2	0.2	1.0	-0.3	0.5	0.0	1.0	-0.1	0.2	-0.0
Relative age voice broke	0.2	0.4	0.9	0.1	-0.6	-0.4	0.9	-0.9	-0.2	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.7	-0.7	0.8	0.4	0.8	0.6	0.7	0.1
Weight	0.2	0.8	1.7	-1.3	-0.8	-1.0	-0.3	-0.7	-1.2	-0.4
Worrier / anxious feelings	0.2	0.3	0.9	0.1	0.0	-0.9	-1.0	0.5	-0.4	-0.3
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.7	-0.5	-0.7	0.8	-0.8	-0.6	-0.1	-0.3
Depression (self-reported)	0.2	0.2	0.7	0.3	0.3	-0.2	0.8	0.3	-0.1	-0.8
Medication: Paracetamol	0.2	0.3	0.8	-0.4	-0.4	-0.3	-0.9	-0.0	-0.6	-0.6
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	3.1	0.1	0.0	-0.2	1.8	-0.2	0.1	0.4
Whole body fat mass	0.2	0.9	2.3	-0.6	-0.9	-1.4	0.8	-0.4	-1.5	-0.2
Leg fat mass (right)	0.2	0.6	1.6	0.1	-0.3	-1.3	1.1	0.1	-1.1	-0.6
Alcohol intake frequency.	0.2	0.4	2.1	1.5	-0.1	-0.4	0.3	0.7	0.4	0.4
Age at last live birth	0.2	0.4	1.5	0.0	0.2	-0.4	-0.6	0.3	1.2	0.6
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.7	0.4	-0.0	0.6	0.1	0.8	0.6	0.6
Supplements: Vitamin C	0.2	0.3	1.1	-0.4	-0.1	0.5	-1.0	0.5	-0.2	0.0
Average weekly red wine intake	0.2	0.3	0.7	-0.9	-0.3	0.5	-0.8	0.0	-0.4	-0.7
Long-standing illness, disability or infirmity	0.2	0.3	1.1	0.3	0.4	-0.3	-0.6	-0.7	1.0	0.1
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.9	0.5	-0.1	-0.2	1.0	-0.7	-0.2	0.7
Medication: Paracetamol	0.2	0.3	0.5	0.5	0.7	-0.5	-0.4	0.6	0.5	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.8	-0.9	-0.3	0.2	-0.5	-0.0	-0.2	-0.5
Heart disease (siblings)	0.2	0.3	1.0	-0.3	0.6	1.0	0.7	0.1	0.2	-0.3
Leg fat mass (left)	0.2	0.6	1.9	-0.0	-0.3	-1.4	0.9	-0.2	-1.1	-0.5
Fasting Glucose	0.1	0.1	0.3	0.4	0.4	0.6	0.3	0.2	0.2	0.1
LDL Cholesterol	0.1	0.2	0.3	0.5	0.1	0.4	-0.4	-0.5	0.1	-0.5
Height	0.1	2.2	10.5	0.9	-0.1	0.9	-1.2	0.2	-1.3	-3.2
Smoking Status	0.1	0.3	1.5	-0.0	0.2	-0.5	-1.2	0.1	0.8	0.3
Allergy or Eczema	0.1	0.3	1.0	1.0	0.8	0.7	0.4	0.0	0.1	0.0
Hair Pigment	0.1	2.4	5.6	0.1	-1.4	0.7	2.4	-2.1	-2.1	-0.7
Tanning	0.1	1.0	2.9	-1.7	-0.6	0.1	1.3	-0.5	-1.0	-0.9
Number of treatments/medications taken	0.1	0.2	0.4	-0.5	0.5	-0.5	0.4	-0.2	0.6	-0.4
Average weekly spirits intake	0.1	0.2	0.5	-0.5	0.7	-0.0	-0.1	0.5	0.2	-0.2
Body mass index (BMI)	0.1	0.6	1.3	-1.1	-0.6	-1.1	0.3	-0.4	-0.7	0.3
Waist circumference	0.1	0.2	1.0	-0.1	0.1	-1.0	-0.7	0.0	-0.0	0.0
Trunk fat-free mass	0.1	0.6	2.0	-0.2	1.1	0.2	-1.4	0.4	0.7	-0.7
Arm fat mass (right)	0.1	0.5	1.5	-0.7	-0.7	-1.0	0.3	-0.3	-1.2	-0.3
Trunk predicted mass	0.1	0.8	2.2	-0.1	1.3	0.0	-1.5	0.5	0.9	-0.6
Standing height	0.1	0.9	3.4	-0.6	-0.2	0.4	-1.9	-0.4	-0.9	-1.2
Arm fat-free mass (right)	0.1	0.4	1.7	-0.6	0.1	-0.1	-1.3	-0.0	0.2	-0.5
Arm predicted mass (right)	0.1	0.3	1.7	-0.4	0.2	-0.1	-1.3	0.1	0.2	-0.5
Overall health rating	0.1	0.3	1.1	0.5	0.1	-1.1	-0.4	-0.1	0.6	0.1
Whole body fat-free mass	0.1	0.6	2.8	-1.1	0.2	-0.1	-1.7	-0.2	0.0	-0.4
Mood swings	0.1	0.3	0.5	-0.5	0.7	0.2	-0.3	-0.5	-0.7	-0.5
Whole body water mass	0.1	0.5	2.6	-0.9	0.2	-0.1	-1.6	-0.1	0.0	-0.6
Arm fat mass (left)	0.1	0.6	1.5	-0.8	-0.9	-1.0	0.3	-0.5	-1.2	-0.2
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.7	-0.8	-0.1	0.0	0.0	-0.2	0.0	0.1
Basal metabolic rate	0.1	0.5	1.8	-1.1	-0.1	-0.3	-1.3	-0.3	-0.4	-0.4
Arm fat-free mass (left)	0.1	0.3	0.9	-0.0	1.0	-0.5	-0.7	0.3	0.7	-0.3
Impedance of whole body	0.1	0.8	2.7	0.5	-0.9	0.3	1.1	-0.4	-1.6	-0.3
Arm predicted mass (left)	0.1	0.5	1.0	0.1	1.0	-0.8	-0.9	0.5	0.8	-0.2
Sitting height	0.0	0.2	1.1	-0.1	-0.0	-0.4	-1.0	0.2	0.1	-0.5

Hub : Genes

TIGD2

Models

Trait associations