TWAS hub - GPRIN3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1600	0.0370	4.5e-07	0.092	0.074	0.105	0.109	0.101	2.6e-11	2.3e-09	9.5e-13	3.5e-13	2.7e-12
2	GTEx	Artery Aorta	0.1790	0.0690	7.6e-03	-0.005	NA	0.011	NA	-0.001	7.7e-01	NA	7.3e-02	NA	3.4e-01
3	GTEx	Vagina	0.4180	0.1440	4.8e-03	0.083	NA	0.018	NA	0.069	6.1e-03	NA	1.2e-01	NA	1.1e-02
4	YFS	Blood	0.1331	0.0305	2.8e-12	0.029	0.060	0.081	0.078	0.027	8.5e-10	4.4e-19	3.8e-25	3.2e-24	3.1e-09
5	TCGA	Brain Lower Grade Glioma	0.0477	0.0215	4.4e-03	0.025	0.014	0.010	NA	0.014	6.1e-04	9.3e-03	2.5e-02	NA	8.0e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Pack years adult smoking proportion	4.9	7.4	21.1	3.3	0.1	4.6	0.7	2.2
Mouth/teeth dental problems: Mouth ulcers	4.7	7.5	12.1	2.4	3.5	1.5	-2.3	3.4
Pack years of smoking	4.5	6.6	20.1	3.0	-0.3	4.5	0.9	1.7
Mean Putamen Volume	3.4	3.9	8.2	-2.0	-1.4	-2.9	1.6	-1.6
Lung FEV1/FVC ratio	3.2	16.1	30.4	-5.5	2.0	-5.5	0.8	-4.0
Illnesses of siblings: Diabetes	3.1	3.9	8.4	2.4	-0.0	2.9	-0.6	2.2
Ever used hormone-replacement therapy (HRT)	3.0	3.9	7.2	1.8	1.5	2.7	-1.2	2.3
Eye problems/disorders: Diabetes related eye disease	3.0	3.3	6.4	1.7	1.8	1.9	-0.6	2.5
Mean time to correctly identify matches	3.0	5.8	12.3	0.6	-2.8	3.5	2.8	0.4
Wears glasses or contact lenses	3.0	3.4	8.6	1.2	-2.9	1.0	2.3	1.0
Exposure to tobacco smoke at home	2.6	2.9	4.7	2.2	-2.1	0.9	1.8	1.2
Comparative body size at age 10	2.6	7.2	17.6	3.5	-0.3	2.4	0.5	4.2
Shortness of breath walking on level ground	2.4	2.9	4.9	2.1	0.3	1.6	1.6	2.2
Crohns Disease (2017)	2.3	5.0	12.9	2.3	1.4	3.6	-0.4	2.2
Chronic bronchitis/emphysema (father)	2.3	2.7	6.3	2.5	1.5	1.7	-0.8	1.1
Pulse rate	2.3	3.8	5.9	1.6	-1.5	2.4	2.3	1.8
Eye problems/disorders: None of the above	2.3	2.7	4.7	-2.0	0.5	-1.0	-1.9	-2.2
Irritable Bowel Disease (IBD)	2.2	5.3	11.7	3.1	-0.7	3.4	-0.2	2.2
Peak expiratory flow (PEF)	2.2	5.0	7.5	-2.2	2.5	-2.7	-1.9	-1.8
Number of children fathered	2.2	2.5	6.1	-2.0	0.1	-2.5	0.2	-1.5
Medication: Allopurinol	2.2	2.9	3.5	-1.4	-1.8	1.9	1.5	-1.9
Long-standing illness, disability or infirmity	2.2	3.3	7.8	1.4	1.8	1.7	-0.9	2.8
Stomach or abdominal pain in last month	2.1	2.6	7.3	1.0	2.7	0.2	-1.5	1.6
Ulcerative Colitis	2.0	2.9	4.9	2.2	-2.1	1.3	1.1	1.4
Had menopause	2.0	2.5	6.6	-1.3	-1.6	1.1	2.6	-0.8
Number of self-reported non-cancer illnesses	2.0	3.5	5.7	2.3	1.7	2.0	0.1	2.4
Reaction Time	1.9	3.6	6.2	0.2	-2.3	2.5	2.5	0.6
High blood pressure	1.9	5.3	11.7	1.7	-0.9	3.4	2.5	2.2
Medication: Levothyroxine sodium	1.9	3.1	6.9	-1.3	2.6	-0.8	-2.0	-1.6
Mouth/teeth dental problems	1.9	2.9	5.4	-1.7	-2.3	-1.6	1.1	-1.6
Medication: Ramipril	1.9	2.4	4.8	1.2	-0.6	2.2	0.8	2.2
Pulse wave reflection index	1.9	2.4	4.9	-1.3	1.8	1.4	-0.0	-2.2
Reason for reducing amount of alcohol drunk: Health precaution	1.9	2.2	3.8	1.9	0.1	2.0	0.7	1.8
Hypertension (Self-reported)	1.9	5.4	11.4	2.0	-1.2	3.4	2.4	2.1
Vascular/heart problems diagnosed by doctor	1.9	5.1	11.8	-2.2	0.9	-3.4	-1.9	-2.1
Neuroticism	1.8	4.4	12.3	2.9	0.1	0.6	1.0	3.5
Gout (self-reported)	1.8	2.5	4.2	-1.3	-1.8	2.1	1.0	-1.6
Ever had stillbirth, spontaneous miscarriage or termination	1.8	1.9	4.9	-2.2	-0.9	-0.8	1.4	-1.1
Breast cancer (self-reported)	1.8	2.1	4.2	0.9	2.0	0.5	-1.1	2.0
Ulcerative Colitis (UC)	1.7	3.1	5.5	2.3	-1.8	2.3	-0.2	1.3
Neuroticism (2016)	1.7	2.5	5.7	1.6	0.4	1.0	2.4	1.7
Blood Red Count	1.7	16.7	46.5	5.2	0.0	6.8	-0.1	3.2
Number of incorrect matches in round	1.7	2.8	6.0	-2.3	-0.6	-0.0	2.5	-1.5
Pulse wave peak to peak time	1.7	2.0	4.6	0.3	-0.2	-2.1	-0.9	2.1
Pulse rate, automated reading	1.7	5.6	11.1	2.1	-0.6	3.3	1.8	3.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	4.1	2.0	-0.7	1.5	-0.5	1.8
Myopia	1.7	2.4	7.2	0.4	-2.7	0.3	2.1	-0.3
Ever unenthusiastic/disinterested for a whole week	1.6	1.9	3.6	1.5	1.3	-0.3	-1.4	1.9
Time employed in main current job	1.6	1.9	5.3	-0.6	-0.8	-0.8	1.5	-2.3
Happiness	1.6	1.9	5.1	2.3	0.6	0.2	1.0	1.8
Pulse wave Arterial Stiffness index	1.6	1.8	4.8	-0.4	0.0	1.8	0.9	-2.2
Health satisfaction	1.6	2.1	4.5	2.1	2.1	0.7	0.4	0.9
Medication: Blood pressure	1.6	2.8	5.8	0.4	-2.4	1.9	2.1	-0.5
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	6.1	0.2	1.6	-0.5	-2.5	0.5
Loneliness, isolation	1.6	2.2	6.3	2.1	-0.1	0.1	0.1	2.5
Guilty feelings	1.6	2.4	5.7	2.1	1.3	0.6	0.3	2.4
Average weekly beer plus cider intake	1.6	2.3	5.4	0.4	-1.6	-1.9	2.3	-0.5
Forced expiratory volume in 1-second (FEV1)	1.5	5.2	10.0	-1.9	1.5	-3.2	-2.6	-1.8
Length of working week for main job	1.5	1.6	3.3	-1.6	0.5	-0.3	-1.4	-1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	1.9	6.1	-0.2	1.5	-0.6	-2.5	0.8
Overall health rating	1.5	3.2	8.0	1.2	2.8	2.3	-0.8	0.8
Osteoporosis (self-reported)	1.5	1.9	3.1	-0.2	-1.5	1.6	1.8	-1.2
Alzheimer’s Disease (including proxy)	1.4	2.0	5.7	-1.4	2.4	0.0	-0.6	-1.4
Crohns Disease (2012)	1.4	2.2	3.1	1.5	1.7	1.4	-1.0	1.8
Lupus	1.4	2.1	4.9	2.0	2.2	-0.0	-1.1	0.7
Number of treatments/medications taken	1.4	2.5	4.3	2.1	1.7	1.6	0.6	1.5
Sensitivity / hurt feelings	1.4	2.5	5.6	1.7	1.9	0.5	0.6	2.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	5.9	0.6	2.4	-0.2	-1.5	1.1
Serious illness, injury or assault to yourself	1.4	1.7	4.0	2.0	0.9	-0.3	-0.1	1.9
Illnesses of siblings	1.4	2.0	5.5	-1.6	-0.5	-2.3	0.0	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.6	13.4	-2.0	0.2	-3.7	-1.0	-2.2
Medication for cholesterol, blood pressure or diabetes	1.4	2.3	3.9	-1.8	2.0	-1.6	-0.6	-1.2
Age at last live birth	1.4	2.0	4.6	-1.5	-2.1	-0.6	1.2	-1.2
Ovarian Cancer	1.3	1.7	5.6	-0.0	2.4	0.9	-1.4	0.0
Cardiovascular Disease	1.3	4.2	7.9	2.3	-1.8	2.8	1.4	1.6
Chronotype (morning person)	1.3	3.0	10.0	1.1	0.4	3.2	-1.9	0.1
Neuroticism score	1.3	2.7	5.4	2.0	1.2	0.7	1.4	2.3
Loud music exposure frequency	1.3	1.4	3.2	-1.0	-0.6	0.8	1.8	-1.4
Glaucoma (self-reported)	1.3	1.5	4.9	-0.3	-2.2	0.9	-1.1	-0.6
Neck or shoulder pain in last month	1.3	1.9	3.3	0.7	1.6	-1.0	-1.5	1.8
Medication for cholesterol	1.3	1.9	6.2	-1.2	-2.5	-0.4	-0.2	-1.3
Medication: Gliclazide	1.3	1.5	3.6	-0.2	1.5	1.9	-1.1	0.4
Financial situation satisfaction	1.3	1.6	3.6	1.9	1.8	0.3	-0.1	1.1
Diastolic blood pressure, automated reading	1.3	4.1	16.1	0.9	-0.5	4.0	0.5	1.8
Supplements: Calcium	1.3	1.5	3.9	2.0	0.4	-0.2	-0.9	1.6
Basal cell carcinoma (self-reported)	1.3	1.5	6.0	-0.6	1.0	-2.4	0.2	0.4
Coronary Artery Disease (CAD)	1.2	1.4	4.0	1.4	0.9	0.3	-0.2	2.0
Medication for hormone replacement therapy	1.2	1.3	2.3	0.5	1.4	-0.5	-1.5	1.3
Taking other prescription medications	1.2	1.8	2.5	1.6	1.5	1.5	-0.3	1.3
Diverticular disease/diverticulitis (self-reported)	1.2	1.5	2.7	-0.6	1.6	1.4	-0.6	-1.4
Financial difficulties in last 2 years	1.2	1.6	6.1	0.9	0.1	0.4	1.0	2.5
High blood pressure (siblings)	1.2	1.7	4.3	1.3	0.3	2.1	0.4	1.6
Medication for pain relief, constipation, heartburn	1.2	2.1	7.4	-2.7	0.4	-0.8	-0.8	-1.3
Supplements: Vitamin C	1.2	1.4	3.7	-0.6	0.6	-1.9	-0.8	-1.4
Eye problems/disorders: Cataract	1.2	1.4	3.1	1.0	-0.1	-0.6	1.8	1.6
Medication: Bendroflumethiazide	1.2	1.9	5.2	0.7	-0.4	2.3	1.8	0.5
Alzheimer’s Disease (in father)	1.1	1.2	3.9	-1.0	2.0	-0.9	-0.4	0.1
Hypothyroidism (self reported)	1.1	2.4	6.1	-1.4	2.5	-0.2	-1.9	-0.8
Maternal smoking around birth	1.1	1.6	2.6	0.8	0.8	1.4	1.5	1.6
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	3.2	0.7	1.1	-1.5	-1.8	0.2
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	3.8	-1.7	1.9	0.4	-1.1	-1.7
Wheeze or whistling in the chest in last year	1.1	1.9	4.9	0.7	2.2	1.8	-0.2	1.0
Age at first live birth	1.1	1.9	5.3	-1.2	-2.3	0.3	1.1	-1.2
Suffer from ‘nerves’	1.1	1.7	4.5	0.7	1.1	1.4	0.5	2.1
Leg pain on walking	1.1	1.4	3.6	-1.9	0.0	-0.5	0.8	-1.6
Commuting to job workplace: Walk	1.1	1.2	3.7	-1.0	-0.9	-1.9	0.7	-0.2
Illnesses of father: High blood pressure	1.1	1.3	3.5	1.3	-0.7	1.9	1.0	0.4
HDL Cholesterol	1.0	1.7	3.7	1.6	0.9	-0.1	-1.2	1.9
Medication: Co-codamol	1.0	1.2	2.2	1.1	-0.9	0.9	0.9	1.5
Diabetes (father)	1.0	1.3	2.3	1.3	-1.5	0.2	1.4	0.7
Hayfever, allergic rhinitis or eczema	1.0	2.2	6.5	-0.6	2.5	-1.3	-0.9	-1.2
Mouth/teeth dental problems: Dentures	1.0	1.7	4.9	1.5	-0.3	2.2	-0.5	1.1
Asthma	1.0	2.0	3.7	0.9	1.9	1.7	1.2	1.0
Medication: Cholesterol lowering	1.0	1.6	3.0	1.6	-0.8	1.3	-0.4	1.7
Prospective memory result	1.0	1.3	4.8	0.1	-0.2	2.2	0.4	1.2
Medication: Amlodipine	1.0	1.4	3.6	0.5	-1.2	0.8	1.9	1.0
Medication: Ventolin 100micrograms inhaler	1.0	1.3	4.5	0.4	-0.5	2.1	1.0	0.7
Birth weight	1.0	2.2	6.3	1.5	1.1	-1.1	0.3	2.5
Had major operations	1.0	1.1	3.2	1.8	0.5	0.4	0.2	1.4
Commuting to job workplace: Car/motor vehicle	1.0	1.1	2.9	0.3	1.7	1.0	-1.3	0.3
Average weekly red wine intake	1.0	1.4	4.1	-2.0	-0.9	-1.3	0.4	-0.6
Asthma (self-reported)	1.0	1.9	4.0	0.7	2.0	1.8	1.0	0.8
Medication: Aspirin	1.0	1.4	4.2	2.1	-0.1	0.7	0.3	1.4
Vitamin and mineral supplements	0.9	1.2	5.4	0.6	-0.3	2.3	-0.3	0.3
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	1.7	0.2	1.2	-1.3	-1.0	0.8
Qualifications: CSEs or equivalent	0.9	1.2	4.3	0.7	0.2	1.1	-2.1	0.3
Arm fat percentage (right)	0.9	3.4	5.6	2.4	0.6	2.4	0.7	2.2
Hair/balding pattern: Pattern 4	0.9	2.3	6.2	2.5	-0.9	0.2	0.1	2.0
Angina (self-reported)	0.9	1.1	2.8	1.5	-0.3	-0.1	-0.7	1.7
Chest pain or discomfort	0.9	1.3	3.6	-0.2	1.9	0.5	-1.4	0.8
Arm fat percentage (left)	0.9	3.7	6.1	2.5	0.5	2.4	0.8	2.4
Back pain experienced in last month	0.9	1.3	3.7	0.9	0.9	0.5	-1.0	1.9
Illnesses of father: None of the above (group 1)	0.9	1.1	3.2	-1.8	-0.9	-0.6	-1.1	0.3
Smoking status: Current	0.9	1.4	3.3	1.8	-0.1	0.0	0.5	1.8
Supplements: Fish oil (including cod liver oil)	0.9	1.2	4.3	-2.1	1.0	-0.7	0.2	-0.2
High cholesterol (Self-reported)	0.9	1.6	5.5	2.3	-0.0	0.6	0.5	1.4
Ever had prostate specific antigen (PSA) test	0.9	1.0	4.3	-0.7	2.1	-0.1	0.7	-0.2
Ever depressed for a whole week	0.9	1.1	2.6	1.3	1.6	0.2	-0.7	0.6
Cholesterol lowering medication	0.9	1.3	3.3	1.6	1.8	-0.6	0.0	0.2
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.0	1.4	-1.3	-0.0	0.8	1.0
Heart attack/myocardial infarction (self-reported)	0.9	1.1	1.9	1.2	0.9	-0.5	-1.4	0.9
Bipolar Disorder (2018)	0.8	1.3	3.4	1.0	-0.9	1.8	0.0	1.1
Depression (Nagel 2018)	0.8	1.2	2.2	1.3	1.5	-0.7	-0.6	1.3
Schizophrenia vs Biploar Disorder	0.8	1.1	4.8	0.1	0.4	-2.2	-0.2	0.6
Allergy or Eczema	0.8	2.2	7.8	0.4	2.8	-0.2	-1.4	-0.9
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	3.3	0.1	1.8	0.3	-1.2	0.6
Angina	0.8	1.1	2.5	1.6	-0.7	0.1	-0.4	1.5
Severe depression (siblings)	0.8	0.9	3.9	0.1	2.0	-0.4	-0.5	-0.1
Trunk fat percentage	0.8	3.1	7.6	2.0	-0.5	2.8	0.8	1.6
Current tobacco smoking	0.8	1.3	3.7	1.6	0.0	0.1	0.5	1.9
Body mass index (BMI)	0.8	3.5	5.9	2.3	0.6	2.4	0.5	2.4
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	6.0	-0.9	2.5	-0.2	1.4	-0.2
Number of live births	0.8	1.1	3.1	1.4	0.3	-0.3	-0.1	1.8
Birth weight of first child	0.8	1.5	3.1	-0.4	-1.2	-1.8	1.6	-0.6
Ever highly irritable/argumentative for 2 days	0.8	0.9	2.7	1.3	-0.2	-0.4	0.2	1.6
Worry too long after embarrassment	0.8	1.4	5.4	0.5	0.7	0.9	2.3	0.3
Medication: Omeprazole	0.8	1.0	1.6	1.1	-1.3	0.0	0.9	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	2.0	0.1	1.4	0.8	-1.2	0.7
Mood swings	0.8	1.4	3.3	1.8	0.1	-0.2	0.7	1.7
Qualifications: nursing, teaching	0.8	1.2	2.0	1.4	-1.2	1.2	0.7	0.7
Hearing aid user	0.8	0.9	1.7	0.7	0.9	0.9	-0.8	1.3
Pain experienced in last month	0.8	1.3	4.1	0.9	-1.3	2.0	0.2	-0.0
Intelligence (Savage-Jansen 2018)	0.7	2.2	4.6	2.2	0.2	0.3	-1.6	1.9
Neuroticism (Nagel 2018)	0.7	1.6	3.2	1.7	0.0	-0.0	1.4	1.8
Triglycerides	0.7	1.2	4.0	-0.9	0.3	2.0	-0.4	-0.9
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.0	-0.2	-1.4	-1.1	-0.7	0.4
BMI	0.7	4.1	8.7	2.3	-1.1	2.3	0.5	2.9
Average weekly spirits intake	0.7	0.9	1.9	-0.9	-1.4	-0.3	1.2	-0.3
Ever had hysterectomy (womb removed)	0.7	0.8	1.3	1.0	1.1	0.7	-0.9	0.5
Medication: Metformin	0.7	1.0	1.9	0.8	1.4	1.3	-0.5	0.6
Hand grip strength (right)	0.7	1.9	6.7	0.1	1.0	-2.6	-0.6	-1.3
Average weekly fortified wine intake	0.7	0.9	2.0	1.4	-0.8	1.2	0.5	-0.0
Relative age voice broke	0.7	1.0	1.9	-0.9	-1.4	1.2	0.9	-0.4
Age when periods started (menarche)	0.7	1.7	3.8	-1.4	-0.2	-1.9	-0.3	-1.7
Waist circumference	0.7	2.7	5.9	2.4	0.5	1.1	0.3	2.4
Alcohol usually taken with meals	0.7	1.1	4.1	-0.8	-0.6	0.6	0.4	-2.0
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.9	1.7	0.2	0.3	-0.6	1.5
Heart attack	0.7	0.9	1.3	1.1	0.8	-0.7	-1.1	1.0
Medication: Simvastatin	0.7	1.1	2.4	1.3	0.4	0.8	-0.8	1.6
Fluid intelligence score	0.7	1.5	3.9	1.7	0.1	0.1	-0.8	2.0
Worrier / anxious feelings	0.7	1.4	5.4	0.7	0.2	0.3	2.3	0.9
Hair/balding pattern: Pattern 3	0.7	1.0	3.4	-0.6	1.0	1.9	0.1	0.1
Lung cancer (father)	0.7	0.8	1.5	-1.1	-0.4	-1.1	-1.2	0.2
Arm fat mass (right)	0.7	3.1	6.8	2.4	0.4	1.6	0.2	2.6
Body fat percentage	0.7	2.7	6.5	1.8	0.1	2.5	0.6	1.8
Number of full brothers	0.7	0.9	1.7	-0.7	1.3	0.7	-0.7	1.2
Emphysema/chronic bronchitis	0.7	0.7	3.4	-0.2	0.4	1.8	0.4	0.1
Medication: Aspirin	0.7	1.0	3.3	1.8	-0.2	0.4	0.3	1.1
Knee pain experienced in last month	0.7	1.1	2.8	-0.8	1.7	-1.0	-1.1	0.2
Illnesses of father: Heart disease	0.7	1.0	3.0	0.4	-0.1	-0.2	1.7	-1.3
Osteoarthritis (self-reported)	0.7	0.9	3.6	-0.0	1.9	0.5	-0.8	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.6	4.3	-0.7	0.6	-1.4	-2.1	-0.9
Arm fat mass (left)	0.7	3.0	6.6	2.3	0.3	1.7	0.2	2.6
Medication: Blood pressure	0.7	1.4	3.9	0.3	1.2	2.0	1.1	0.4
Number of operations (self-reported)	0.7	1.0	4.0	1.0	0.2	2.0	0.2	-0.3
Age started oral contraceptive pill	0.7	0.9	2.3	-1.5	0.8	0.3	0.3	-1.2
Worry (Nagel 2018)	0.6	1.3	2.8	1.4	0.6	0.3	1.1	1.7
Bipolar Disorder (2011)	0.6	0.5	1.8	0.2	-0.8	1.3	-0.5	0.0
Fasting Glucose	0.6	0.8	2.4	-1.5	-0.0	-0.3	-0.7	-0.9
Primary Biliary Cirrhosis	0.6	0.9	3.2	0.5	0.3	0.6	-0.9	1.8
Hand grip strength (left)	0.6	1.5	5.2	-0.7	0.4	-2.3	0.1	-1.4
Frequency of depressed mood in last 2 weeks	0.6	0.8	2.8	0.7	0.8	-0.2	-0.4	1.7
Impedance of leg (right)	0.6	2.9	7.4	-2.7	-0.0	-0.9	-1.2	-2.2
Multivitamins +/- minerals	0.6	0.7	2.7	-0.4	1.6	-0.9	0.0	-0.2
Supplements: Glucosamine	0.6	0.8	3.6	0.4	-0.4	0.2	1.9	-0.4
Trunk fat mass	0.6	2.6	4.6	2.1	-0.4	2.1	0.6	1.8
Nervous feelings	0.6	1.1	3.8	0.5	0.7	0.3	2.0	1.1
Forced vital capacity (FVC)	0.6	2.3	7.5	-0.0	0.7	-1.9	-2.7	-0.3
Allergy	0.6	1.3	6.0	0.1	-2.4	-0.2	-0.4	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.6	0.3	1.3	-0.3	-1.2	1.1
Heart disease (mother)	0.6	0.7	1.9	-0.4	1.2	-0.1	-1.4	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.7	-0.1	1.3	0.8	-0.6	-0.9
Whole body fat mass	0.6	2.5	4.4	2.0	-0.0	2.0	0.4	2.1
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	2.1	1.4	-1.1	-0.9	-0.9	1.1
Ever had bowel cancer screening	0.6	0.7	1.6	-0.2	0.9	0.9	1.2	0.5
Diabetes diagnosed by doctor	0.6	0.9	1.5	1.1	0.8	1.2	-0.0	1.1
Leg fat percentage (left)	0.6	2.3	7.3	1.3	0.9	2.7	0.5	1.2
Risk taking	0.6	0.9	1.9	-1.0	1.1	-1.4	-0.6	0.1
Fractured/broken bones in last 5 years	0.6	0.8	3.3	0.3	-0.0	1.8	0.1	-0.7
Commuting to job workplace: Cycle	0.6	0.7	2.2	-0.3	0.6	-1.5	0.1	-0.9
Alcohol drinker status: Previous	0.6	0.7	1.9	1.4	0.4	0.8	-0.3	0.8
Major Depression (MDD)	0.5	0.6	1.6	-0.4	1.3	1.1	0.4	-0.3
Rheumatoid Arthritis	0.5	0.7	1.8	-1.2	-0.5	-1.3	-0.1	0.1
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.5	0.8	1.6	0.5	-0.4	0.9
Systolic blood pressure, automated reading	0.5	1.4	5.6	0.4	-0.1	2.4	0.2	1.1
Diabetes (mother)	0.5	0.7	1.4	-0.6	1.2	-0.6	-0.8	0.8
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.6	0.5	0.3	0.5	-1.3	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	4.2	-0.1	2.1	0.3	1.0	0.6
High blood pressure (mother)	0.5	0.7	2.8	0.3	-0.8	1.7	0.3	0.1
Impedance of leg (left)	0.5	2.5	6.4	-2.5	0.3	-0.9	-1.1	-2.0
Hearing difficulty/problems with background noise	0.5	0.7	1.8	-0.3	0.3	1.3	0.6	1.1
Pain all over the body in last month	0.5	0.5	1.5	0.1	1.2	0.1	-0.9	0.4
Diabetes (self-reported)	0.5	0.7	1.9	0.6	1.0	1.4	0.4	0.6
Hip circumference	0.5	2.0	3.6	1.9	1.1	1.8	0.2	1.4
Headache pain in last month	0.5	0.8	1.9	0.5	0.6	-0.7	1.0	1.4
Forced vital capacity (FVC), Best measure	0.5	1.8	6.5	-0.1	-0.2	-2.5	-1.4	-0.9
Leg fat percentage (right)	0.5	1.9	6.6	1.1	0.9	2.6	0.2	1.0
Leg fat mass (right)	0.5	1.8	3.0	1.6	0.8	1.7	-0.0	1.7
Number of full sisters	0.5	0.6	2.2	-0.6	1.5	-0.4	-0.6	-0.1
Smoking status: Previous	0.5	0.7	2.3	-0.9	0.6	0.1	-0.5	-1.5
Handedness (chirality/laterality): Left-handed	0.5	0.5	1.0	-0.9	-1.0	0.2	0.4	0.9
Friendships satisfaction	0.5	0.6	1.4	-0.4	1.2	-0.4	-0.5	1.1
Commuting to job workplace: Public transport	0.5	0.6	1.3	-1.0	-0.1	-0.9	0.3	-1.1
Unable to work because of sickness or disability	0.5	0.6	1.6	1.3	0.0	-0.3	1.1	0.6
Leg fat mass (left)	0.5	2.0	3.5	1.7	0.7	1.8	0.1	1.9
Depressed Affect (Nagel 2018)	0.4	0.9	2.6	1.2	-0.7	-0.3	0.2	1.6
Alzheimer’s Disease (in mother)	0.4	0.5	1.2	-0.6	0.8	-0.1	-0.3	-1.1
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.4	1.1	0.9	0.7	-1.2	0.6
Breast Cancer	0.4	1.0	4.0	-0.8	-0.1	0.7	0.3	-2.0
LDL Cholesterol	0.4	0.6	1.9	-0.2	0.4	-0.2	-1.4	0.9
Respiratory disease	0.4	0.9	2.2	0.7	1.5	0.6	1.0	0.6
Leg fat-free mass (left)	0.4	2.2	5.8	2.4	-0.1	0.1	0.0	2.3
Townsend deprivation index at recruitment	0.4	0.6	1.8	0.0	-0.8	0.3	0.7	1.3
Medication: Atenolol	0.4	0.5	0.8	0.9	-0.7	-0.6	0.9	0.0
Leg predicted mass (left)	0.4	2.0	5.0	2.2	-0.1	0.1	0.0	2.2
Weight	0.4	1.8	4.2	2.0	-0.1	0.9	0.1	2.0
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.2	-0.1	0.8	0.0	-1.1	1.0
Falls in the last year	0.4	0.5	1.1	-0.5	-0.5	1.0	0.9	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	0.9	0.7	-0.9	-0.5	0.3	0.7
Depression (self-reported)	0.4	0.5	1.3	0.8	0.5	-0.1	-1.1	0.5
Medication: Lansoprazole	0.4	0.5	2.2	0.2	1.5	-0.1	-0.1	0.3
Illnesses of mother	0.4	0.5	2.1	0.4	-0.2	-0.2	1.4	0.1
Breastfed as a baby	0.4	0.4	0.6	-0.8	-0.6	0.7	0.4	-0.8
Migraine (self-reported)	0.4	0.5	2.1	-0.2	1.4	-0.0	-0.5	0.0
Medication: Ibuprofen	0.4	0.5	1.1	1.0	0.8	0.7	0.0	0.7
Leg fat-free mass (right)	0.4	2.2	5.6	2.4	0.1	0.0	0.1	2.4
Leg predicted mass (right)	0.4	2.3	5.9	2.4	0.1	0.1	0.1	2.4
Average weekly champagne plus white wine intake	0.4	0.5	1.5	0.6	-0.4	1.2	-0.8	0.3
Ever taken oral contraceptive pill	0.4	0.5	1.5	0.7	1.2	-0.0	0.5	0.4
Mother’s age at death	0.4	0.5	2.0	0.2	-1.4	-0.2	-0.8	0.0
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.5	-0.4	-0.5	-0.3	-0.0	-1.2
Eye problems/disorders: Glaucoma	0.4	0.5	1.4	-0.1	-1.2	0.7	-0.7	0.1
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.6	-0.1	1.3	-0.3	-0.4	0.6
Heart disease (siblings)	0.4	0.5	1.5	0.0	1.2	-0.9	-0.2	-0.3
Bipolar Disorder or Schizophrenia	0.3	0.6	1.9	0.3	-0.9	0.5	0.5	1.4
Age at First Birth	0.3	0.4	0.9	-0.2	1.0	0.5	-0.3	-0.8
HbA1C	0.3	0.4	0.6	-0.3	-0.6	0.6	-0.7	-0.8
Blood Eosinophil Count	0.3	2.2	7.7	0.1	1.1	2.8	-1.4	0.2
Waist Hip Ratio (WHR)	0.3	1.2	2.6	1.2	-0.3	-1.3	-0.4	1.6
Lung FVC	0.3	1.7	2.9	-0.5	0.1	-1.6	-1.6	-1.7
Hearing difficulty/problems: Yes	0.3	0.5	1.5	-1.2	0.8	-0.2	0.2	0.5
Supplements: Zinc	0.3	0.3	0.6	0.8	0.7	-0.3	-0.2	0.5
Fed-up feelings	0.3	0.5	1.1	-0.2	0.3	0.9	0.5	1.0
Hair/balding pattern: Pattern 2	0.3	0.4	0.9	0.5	-0.3	-0.8	-0.9	-0.1
Qualifications: None of the above	0.3	0.6	1.2	-1.1	0.3	-0.3	1.0	-0.6
Noisy workplace	0.3	0.4	1.5	-0.1	0.1	-0.7	-0.1	-1.2
Qualifications: A levels/AS levels or equivalent	0.3	0.8	2.6	0.6	0.8	-0.2	-1.6	0.5
Standing height	0.3	2.7	10.8	-0.3	-1.4	-3.3	-1.0	-0.2
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.7	1.3	-0.7	0.2	-0.3	-0.4
Blood clot in the leg (DVT)	0.3	0.4	1.2	0.4	-0.1	0.6	0.3	1.1
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.7	-0.6	0.3	0.0	-0.8	-0.7
Arm fat-free mass (right)	0.3	1.4	3.1	1.8	-0.3	-0.2	-0.8	1.8
Exposure to tobacco smoke outside home	0.3	0.5	1.1	-0.0	0.9	-1.0	0.0	-0.6
Medication: Seretide 50 evohaler	0.3	0.3	1.3	-0.4	-0.1	1.1	-0.0	0.3
Alcohol intake frequency.	0.3	0.7	1.4	-0.7	1.1	0.1	-1.2	-0.6
Family relationship satisfaction	0.3	0.4	0.9	0.5	1.0	0.2	-0.4	0.7
Whole body fat-free mass	0.3	1.7	4.4	1.9	-0.1	-0.6	-0.5	2.1
Whole body water mass	0.3	1.6	4.1	1.8	-0.3	-0.7	-0.5	2.0
Miserableness	0.3	0.4	1.6	0.3	0.6	-0.1	-0.4	1.2
Basal metabolic rate	0.3	1.8	4.6	2.0	-0.1	-0.2	-0.5	2.1
Irritability	0.3	0.6	1.1	0.5	1.0	-0.8	0.6	0.7
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.4	0.3	-0.5	0.4	0.3	1.2
Arm predicted mass (left)	0.3	1.6	4.0	1.8	-0.3	-0.1	-0.9	2.0
Schizophrenia (2018)	0.2	0.5	0.8	-0.5	-0.4	-0.9	0.6	0.9
Prostate Cancer	0.2	0.2	0.5	0.7	-0.4	-0.2	-0.0	0.6
Schizophrenia (2014)	0.2	0.5	1.2	-0.5	-1.1	-0.4	0.9	0.5
Height	0.2	4.1	16.5	0.8	-1.8	-4.1	-0.4	-0.4
Systolic Blood Pressure	0.2	1.1	3.2	0.0	0.1	1.8	-0.6	1.4
Sitting height	0.2	1.7	5.0	-1.1	-0.4	-1.4	-2.2	-0.6
Past tobacco smoking	0.2	0.3	0.8	0.6	-0.2	0.7	0.3	0.9
Had other major operations	0.2	0.2	0.6	0.5	0.3	0.8	-0.5	-0.2
Trunk fat-free mass	0.2	1.2	2.2	1.2	-0.2	-1.3	-0.7	1.5
Alcohol intake versus 10 years previously	0.2	0.3	0.9	1.0	-0.0	-0.5	-0.3	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.4	0.6	0.7	0.5	-0.1	0.4
Trunk predicted mass	0.2	1.1	2.2	1.2	-0.3	-1.2	-0.7	1.5
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	1.2	0.4	1.1	-0.2	0.1	-0.2
Medication: Paracetamol	0.2	0.3	0.9	0.3	-0.2	0.1	0.7	1.0
Qualifications: College or University degree	0.2	0.6	0.7	0.8	-0.8	-0.7	0.7	0.8
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.5	0.7	-0.5	-0.2	0.6	0.0
Arm predicted mass (right)	0.2	1.2	2.8	1.7	-0.4	-0.3	-0.7	1.6
Comparative height size at age 10	0.2	1.1	4.0	0.5	-0.1	-2.0	0.7	0.9
Mineral and other dietary supplements	0.2	0.3	0.6	0.1	-0.0	0.8	-0.7	-0.4
Medication: Paracetamol	0.2	0.2	0.6	-0.4	0.8	-0.0	0.1	0.7
Medication: Atorvastatin	0.2	0.2	0.6	0.1	0.3	0.5	0.3	-0.8
Alcohol drinker status: Never	0.2	0.3	0.9	-0.5	0.0	-0.1	1.0	-0.5
Arm fat-free mass (left)	0.2	1.1	2.8	1.3	-0.0	-0.3	-1.1	1.7
Impedance of whole body	0.2	1.0	2.5	-1.6	-0.3	-0.4	-0.5	-1.4
Body Mass Index (BMI) (2010)	0.1	0.1	0.3	0.2	0.4	0.3	0.5	0.1
Blood Platelet Count	0.1	0.9	2.2	-1.2	-0.8	-1.5	-0.6	-0.0
Blood White Count	0.1	0.5	2.0	-0.0	-0.5	1.4	-0.5	-0.2
Heel T-Score	0.1	1.1	3.6	-0.8	1.0	-0.4	1.9	-0.1
Smoking Status	0.1	0.3	1.0	1.0	0.2	0.4	0.3	0.5
Tanning	0.1	1.1	3.3	-1.8	-1.0	-0.5	0.7	-0.8
Relative age of first facial hair	0.1	0.3	1.2	-1.1	-0.2	0.3	0.0	-0.3
Impedance of arm (right)	0.1	0.7	1.4	-1.2	-0.3	-1.0	0.1	-0.9
Impedance of arm (left)	0.1	0.5	0.9	-0.9	-0.5	-0.8	0.3	-0.9
Tense / ‘highly strung’	0.1	0.1	0.3	0.2	0.2	-0.4	0.3	-0.6
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.4	-0.1	-0.0	0.3	0.6	-0.7
Medication: Lisinopril	0.1	0.2	0.4	0.0	0.2	0.6	0.4	-0.6
Ever smoked	0.1	0.1	0.2	0.1	-0.4	-0.4	-0.1	-0.3
Hair Pigment	0.0	0.3	0.7	-0.1	-0.4	-0.7	-0.4	-0.8
Father’s age at death	0.0	0.1	0.1	-0.3	-0.2	-0.3	0.2	0.3

Hub : Genes

GPRIN3

Models

Trait associations