Hub : Genes

FAM13A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1160	0.0460	1.0e-03	0.002	NA	0.009	NA	0.007	2.3e-01	NA	6.9e-02	NA	8.3e-02
2	ROSMAP	Brain Pre-frontal Cortex	0.1229	0.0285	1.3e-11	0.131	0.121	0.123	0.125	0.127	1.8e-16	2.5e-15	1.4e-15	8.9e-16	5.9e-16
3	TCGA	Breast Invasive Carcinoma	0.0288	0.0186	3.6e-03	0.022	0.011	0.011	NA	0.013	2.0e-05	1.9e-03	1.7e-03	NA	8.8e-04
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.0364	0.0208	5.6e-03	0.018	0.006	0.001	NA	0.009	3.7e-03	6.1e-02	2.4e-01	NA	2.8e-02
5	TCGA	Brain Lower Grade Glioma	0.0567	0.0273	1.4e-03	0.004	0.019	0.002	NA	0.000	1.1e-01	2.4e-03	1.9e-01	NA	2.8e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.0	1.6	3.7	-1.2	-1.4	0.7	-1.9	0.6
Bipolar Disorder or Schizophrenia	0.5	1.3	2.4	-1.3	-0.8	1.6	-0.9	1.0
Depressed Affect (Nagel 2018)	0.2	0.5	1.2	0.1	0.9	-0.3	-0.4	1.1
Depression (Nagel 2018)	0.2	0.3	0.9	-0.2	0.3	-0.6	-0.0	1.0
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.1	0.1	-0.6	1.1	0.6	-0.6
Neuroticism (Nagel 2018)	0.3	0.6	2.4	-0.3	0.2	-0.2	-0.7	1.6
Schizophrenia (2018)	0.3	0.7	2.1	-0.7	0.1	1.5	0.3	0.8
Schizophrenia vs Biploar Disorder	1.1	1.5	4.8	1.4	-0.1	-0.3	2.2	-0.8
Worry (Nagel 2018)	0.4	0.9	3.3	-0.3	-0.2	-0.1	-1.0	1.8
Alzheimer’s Disease (in mother)	1.3	1.5	4.5	-0.6	1.1	0.7	-1.0	2.1
Alzheimer’s Disease (in father)	0.2	0.2	0.7	-0.1	0.5	-0.8	0.4	-0.1
Alzheimer’s Disease (including proxy)	0.5	0.8	1.6	-0.9	0.4	0.5	-1.0	1.3
Crohns Disease (2017)	1.4	3.1	5.0	-2.0	-2.0	1.5	-2.2	-0.7
Irritable Bowel Disease (IBD)	1.3	3.1	5.0	-2.2	-1.7	1.4	-1.7	-1.7
Ulcerative Colitis (UC)	1.4	2.6	4.9	-2.2	-1.2	1.2	-0.8	-2.1
Major Depression (MDD)	0.9	1.1	2.9	-1.7	-0.9	0.5	-1.1	0.5
Reaction Time	3.6	6.8	16.1	-3.6	-4.0	0.1	-2.1	-0.9
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.2	-1.0	-1.5	1.2	0.1	-0.5
Breast Cancer	1.2	2.9	7.1	-0.6	1.6	0.9	-2.0	2.7
Ovarian Cancer	0.3	0.4	0.8	0.3	0.9	0.7	-0.6	0.6
Prostate Cancer	0.2	0.3	0.5	0.4	0.1	-0.7	-0.4	0.7
Age at First Birth	0.2	0.3	1.0	-0.5	-0.4	0.2	-1.0	-0.0
Bipolar Disorder (2011)	1.7	1.7	4.1	-1.1	-0.7	0.3	-2.0	1.5
Body Mass Index (BMI) (2010)	1.0	1.3	3.8	-2.0	-1.1	0.2	0.1	-1.3
Coronary Artery Disease (CAD)	0.9	1.1	4.2	0.4	0.9	-0.0	-0.6	2.1
Crohns Disease (2012)	0.7	1.2	3.0	-0.4	-1.5	1.7	-0.7	-0.1
Mean Putamen Volume	0.6	0.6	2.0	0.7	-0.3	-0.7	1.4	0.1
Fasting Glucose	0.6	0.7	1.5	-1.2	-1.2	0.0	0.4	-0.7
HbA1C	0.2	0.2	0.4	0.4	0.5	-0.6	-0.5	0.2
HDL Cholesterol	1.9	3.2	6.9	-1.1	-2.6	0.7	1.1	-2.5
LDL Cholesterol	0.3	0.4	1.1	0.8	0.5	-0.1	-0.3	1.1
Lupus	0.7	1.1	3.9	0.6	0.0	0.9	0.5	2.0
Neuroticism (2016)	0.5	0.7	1.8	-0.2	-0.7	-1.0	0.5	-1.3
Primary Biliary Cirrhosis	0.1	0.1	0.4	0.6	-0.1	0.1	-0.1	0.1
Rheumatoid Arthritis	0.6	0.8	1.7	-1.1	-1.3	-0.7	0.7	-0.2
Schizophrenia (2014)	0.7	1.5	5.4	-0.3	0.1	2.3	-0.2	1.4
Triglycerides	1.2	1.9	4.6	-0.9	0.4	1.1	-2.2	1.7
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.2	1.5	1.5	0.7	0.2	0.2
Ulcerative Colitis	0.9	1.3	2.3	-1.1	-1.1	1.5	0.6	-1.1
Blood Eosinophil Count	1.4	11.0	15.9	-4.0	-0.8	3.9	-3.9	2.9
Blood Platelet Count	0.6	6.4	15.6	-3.5	-4.0	-1.5	0.1	1.4
Blood Red Count	0.5	5.0	13.6	-1.3	1.0	2.7	-3.7	1.3
Blood White Count	0.9	6.7	13.8	-2.8	-1.4	1.4	-2.8	3.7
Heel T-Score	0.4	3.0	10.0	-2.1	-3.2	0.2	-0.6	0.3
BMI	0.7	4.1	9.4	-3.1	-2.4	-1.1	-0.2	-2.0
Height	0.2	4.5	12.4	2.3	-0.2	-0.9	3.5	-1.9
Waist Hip Ratio (WHR)	4.6	20.8	56.8	6.1	2.9	0.4	-0.9	7.5
Systolic Blood Pressure	1.4	7.1	20.2	-0.6	0.7	1.3	-3.6	4.5
Smoking Status	0.5	1.2	3.2	0.2	1.5	-0.2	-0.7	1.8
Allergy or Eczema	0.4	1.1	4.1	2.0	1.1	0.2	0.1	0.7
Cardiovascular Disease	1.1	3.5	9.1	-0.9	0.8	1.5	-2.2	3.0
Hypothyroidism (self reported)	0.3	0.7	1.9	-1.1	0.0	1.4	-0.3	-0.3
Respiratory disease	1.0	2.3	5.2	-0.9	0.2	-1.2	-2.3	2.0
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.1	1.1	-0.0	-0.8	-0.6	0.2
Lung FEV1/FVC ratio	11.2	56.9	98.2	7.4	6.5	-9.9	3.8	-8.6
Lung FVC	1.0	5.3	15.1	1.1	-1.1	3.0	0.4	3.9
Neuroticism	0.5	1.2	2.5	-0.8	-0.1	-1.0	-1.3	1.6
Chronotype (morning person)	2.2	5.1	9.7	-3.1	-1.9	1.9	-2.9	-0.6
Hair Pigment	0.2	4.5	11.3	3.4	0.3	-1.4	1.9	-2.4
Tanning	0.0	0.4	1.4	0.1	-0.3	0.1	0.6	-1.2
Hand grip strength (left)	0.7	1.8	2.7	1.6	1.6	-1.6	1.1	0.4
Number of treatments/medications taken	0.3	0.5	1.2	0.4	0.1	-0.8	-1.1	0.9
Average weekly spirits intake	0.2	0.3	0.5	-0.7	-0.7	-0.5	-0.3	-0.1
Sensitivity / hurt feelings	0.3	0.6	1.5	-1.2	-1.1	-0.2	0.3	0.1
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.4	-0.3	0.3	-1.2	-0.0	0.1
Hearing difficulty/problems: Yes	0.2	0.4	0.8	0.4	-0.9	-0.9	-0.1	-0.0
Relative age of first facial hair	0.5	1.0	2.4	-0.9	-1.2	-0.6	-1.6	0.2
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.4	0.5	-0.2	-0.1	0.2	0.6
Ever used hormone-replacement therapy (HRT)	2.5	3.1	9.3	-1.8	-0.5	1.0	-3.0	1.3
Ever had hysterectomy (womb removed)	0.8	0.9	3.6	0.5	0.6	-0.6	-0.2	-1.9
Systolic blood pressure, automated reading	1.1	3.1	9.0	-0.9	0.4	0.5	-3.0	2.3
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.5	-0.1	0.3	0.7	-0.6	-0.4
Angina	0.7	1.0	3.4	0.9	1.8	0.1	0.8	0.1
Medication for hormone replacement therapy	0.8	0.8	2.9	-0.7	-1.7	0.2	0.8	-0.5
Vitamin and mineral supplements	0.5	0.6	1.8	-1.0	0.2	0.5	-1.3	-0.4
Supplements: Zinc	0.3	0.3	0.8	0.7	-0.2	0.1	0.9	-0.0
Medication: Co-codamol	1.6	1.8	4.3	-1.3	-1.0	2.1	-1.0	1.1
Medication: Metformin	0.4	0.5	2.2	-0.1	0.2	0.4	-1.5	0.3
Diabetes (father)	0.4	0.5	1.1	1.0	-0.3	-0.7	0.6	-0.7
Diabetes (mother)	0.1	0.1	0.3	-0.3	0.1	-0.5	-0.3	0.4
Severe depression (siblings)	0.3	0.3	0.8	0.2	0.4	0.9	0.4	0.8
Pack years adult smoking proportion	3.5	5.3	16.3	-1.2	1.0	-0.0	-4.0	2.8
Impedance of leg (right)	0.3	1.4	5.3	0.2	2.3	1.1	-0.5	0.4
Leg fat-free mass (left)	0.4	2.3	5.0	-1.4	-2.2	-0.9	1.3	-1.4
Trunk fat percentage	2.0	8.0	24.0	-4.9	-2.3	0.5	-0.1	-3.2
Hand grip strength (right)	0.7	1.9	3.9	1.9	1.0	-1.0	2.0	-0.1
Townsend deprivation index at recruitment	0.2	0.2	0.6	-0.4	0.8	-0.6	-0.3	-0.1
Current tobacco smoking	0.4	0.7	2.3	-0.3	1.5	-0.5	-0.7	0.5
Average weekly fortified wine intake	0.2	0.3	1.0	1.0	0.5	-0.2	0.2	0.1
Maternal smoking around birth	1.8	2.6	7.0	-1.2	0.8	0.6	-1.9	2.6
Fed-up feelings	1.3	2.4	4.7	-0.8	1.4	0.0	-2.2	2.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.5	-0.7	-0.6	-0.6	-0.5	0.2
Relative age voice broke	0.9	1.3	2.6	-0.9	-0.8	1.6	-1.2	-1.0
Taking other prescription medications	0.6	1.0	2.2	0.4	0.5	-1.1	-1.5	1.0
Age when periods started (menarche)	0.5	1.1	3.2	-0.0	-1.4	-1.8	0.5	-0.3
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.3	0.5	0.3	0.4	-1.0	1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.4	-0.1	-0.4	0.0	-0.5	0.6
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	4.3	2.1	1.3	-0.5	1.4	-0.3
Qualifications: CSEs or equivalent	0.4	0.5	1.8	-1.3	0.3	-0.5	0.2	-0.7
Serious illness, injury or assault to yourself	1.4	1.7	4.5	2.1	1.4	-1.1	0.8	0.6
High blood pressure	2.1	5.8	13.9	-1.9	-0.4	0.9	-3.7	3.3
Hayfever, allergic rhinitis or eczema	0.9	1.9	5.5	2.3	1.8	-0.1	0.4	0.7
Multivitamins +/- minerals	0.2	0.3	0.8	0.7	-0.3	0.3	0.9	0.1
Stomach or abdominal pain in last month	0.5	0.7	1.7	-0.1	-0.3	1.3	-0.9	0.9
Supplements: Glucosamine	0.4	0.5	2.2	1.5	0.3	-0.0	0.1	-0.1
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	3.5	-1.3	-0.4	0.0	-1.9	0.5
Medication: Atenolol	2.0	2.5	6.6	2.6	1.6	-0.5	1.2	1.2
Medication: Levothyroxine sodium	0.2	0.3	1.0	0.1	-0.5	0.2	0.7	-1.0
Sitting height	0.0	0.3	0.6	-0.5	-0.8	0.4	0.7	0.2
Chronic bronchitis/emphysema (father)	2.5	2.9	6.1	-2.5	-1.6	2.1	-1.2	0.0
High blood pressure (mother)	2.4	3.3	6.3	-2.5	-2.1	1.1	-2.1	0.7
Body mass index (BMI)	0.6	2.6	7.4	-2.7	-1.4	-1.3	-0.6	-1.1
Impedance of leg (left)	0.2	1.1	4.9	-0.1	2.2	0.8	-0.4	0.2
Leg predicted mass (left)	0.4	2.1	4.7	-1.2	-2.2	-0.9	1.3	-1.4
Trunk fat mass	1.3	5.6	17.0	-4.1	-1.9	-0.0	0.2	-2.7
Waist circumference	0.1	0.5	1.8	-0.5	-0.1	-1.3	-0.1	0.8
Number of incorrect matches in round	2.3	3.8	9.3	0.9	3.1	-1.3	-1.7	2.2
Past tobacco smoking	0.2	0.3	0.8	0.1	0.7	0.4	-0.1	-0.9
Alcohol usually taken with meals	0.4	0.7	2.8	-1.7	0.1	0.7	-0.4	-0.1
Nervous feelings	0.1	0.2	0.6	-0.3	-0.4	0.1	-0.5	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.7	-0.1	0.8	-0.7	-0.6	1.3
Hearing difficulty/problems with background noise	0.3	0.5	0.9	0.3	0.9	-0.8	-0.9	-0.0
Hair/balding pattern: Pattern 2	0.7	1.0	2.8	0.6	-0.1	1.2	-0.4	1.7
Had menopause	1.0	1.3	3.1	0.0	-0.1	-0.7	-1.6	1.8
Had other major operations	0.2	0.3	0.6	0.6	0.4	-0.5	-0.8	-0.2
Forced vital capacity (FVC)	0.4	1.7	3.2	0.8	-1.7	1.1	1.8	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.1	-0.4	-0.2	-0.0	-0.8	1.0
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	7.0	0.0	-0.6	-2.6	0.3	-0.3
Qualifications: None of the above	0.7	1.6	4.0	2.0	1.2	-0.9	1.0	-0.8
Financial difficulties in last 2 years	1.2	1.7	3.6	-1.6	-1.3	0.7	-0.5	1.9
Mouth/teeth dental problems	0.5	0.8	2.8	-0.4	-1.7	-0.5	0.5	-0.8
Heart attack	0.6	0.8	1.8	1.2	0.1	-0.7	1.3	0.4
Allergy	0.9	2.1	4.1	-1.3	-1.6	-0.3	1.5	-2.0
Pain all over the body in last month	0.2	0.2	0.7	0.1	0.1	-0.7	-0.2	-0.8
Diabetes (self-reported)	0.3	0.5	1.0	0.8	0.8	-0.0	-1.0	0.3
Hayfever/allergic rhinitis (self-reported)	2.9	3.8	8.5	2.9	2.5	-0.9	1.5	-1.0
Medication: Ramipril	1.5	1.9	4.0	-1.3	0.1	0.9	-2.0	1.8
Medication: Simvastatin	1.0	1.4	5.0	0.7	1.0	0.5	-0.5	2.2
Fluid intelligence score	0.5	1.1	3.1	-0.7	-1.8	1.3	0.4	0.1
Illnesses of siblings	2.3	3.3	7.1	2.3	0.5	-1.3	2.7	-1.4
Neuroticism score	0.4	0.9	1.2	-1.0	-0.7	-0.9	-1.1	1.0
Weight	0.6	2.8	5.3	-2.3	-1.8	-1.3	0.6	-1.7
Impedance of arm (right)	1.0	4.8	11.6	-1.9	-1.4	1.8	1.8	-3.4
Arm fat percentage (right)	1.4	5.5	13.4	-3.7	-2.0	-0.8	0.3	-3.1
Trunk fat-free mass	0.2	1.2	3.0	1.3	0.1	-1.7	0.7	0.9
Hip circumference	1.3	5.5	12.5	-3.5	-2.1	-0.9	0.7	-3.1
Time employed in main current job	0.8	1.0	1.6	1.3	1.3	-0.5	1.1	0.4
Alcohol intake versus 10 years previously	0.4	0.7	1.3	-1.0	-1.1	-0.7	0.6	0.2
Father’s age at death	0.7	1.0	2.2	1.3	1.1	-0.0	-0.1	1.5
Worrier / anxious feelings	0.2	0.4	1.1	-0.8	-0.6	-1.0	-0.0	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	1.9	-1.4	-0.7	-0.1	-1.1	0.9
Falls in the last year	1.1	1.4	4.7	-2.2	-0.7	0.9	-1.0	-0.3
Hair/balding pattern: Pattern 3	1.0	1.4	2.7	-0.9	-1.1	1.6	-1.4	-0.7
Number of live births	1.6	2.3	5.1	2.3	1.1	-0.2	1.5	-1.6
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	6.5	2.1	-0.4	-1.0	2.5	-1.4
Pulse rate	1.6	2.6	6.2	-2.1	-0.9	0.2	-2.5	1.3
Happiness	0.6	0.7	2.3	-1.5	-0.3	-1.0	-0.4	-0.1
Noisy workplace	1.1	1.3	2.5	1.6	1.0	-1.4	0.8	-0.6
Qualifications: A levels/AS levels or equivalent	0.7	1.5	5.1	-0.8	-2.3	0.7	0.6	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	1.8	0.5	-1.3	-0.9	1.0	-1.2
Mouth/teeth dental problems: Dentures	0.4	0.7	1.5	-0.5	0.8	0.9	-1.2	0.2
Asthma	1.8	3.5	9.0	-1.6	-0.1	0.2	-3.0	2.5
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.9	0.4	0.7	0.3	-0.1	0.9
Medication: Cholesterol lowering	0.6	0.9	1.7	-1.3	-0.0	0.6	-1.0	1.2
Depression (self-reported)	0.3	0.4	0.7	0.7	0.4	-0.8	0.0	-0.7
Medication: Lansoprazole	0.2	0.2	0.5	0.3	0.7	0.1	0.2	0.7
Prospective memory result	0.7	0.9	1.4	-0.8	0.9	-0.7	-1.1	-1.2
Lung cancer (father)	0.4	0.4	0.9	0.9	0.1	-0.9	0.4	0.4
Illnesses of mother	2.0	2.5	4.9	1.2	-0.0	-1.9	1.6	-2.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.7	11.1	2.0	-0.7	-1.6	3.3	-2.2
Pulse wave Arterial Stiffness index	0.6	0.7	2.5	-0.7	-0.2	0.5	-1.6	0.4
Impedance of arm (left)	1.3	6.2	12.9	-2.1	-1.8	2.4	2.3	-3.6
Arm fat mass (right)	0.8	3.2	8.8	-3.0	-1.5	-1.0	0.3	-2.0
Trunk predicted mass	0.2	1.2	3.2	1.2	0.1	-1.8	0.6	1.1
Standing height	0.2	2.1	7.7	0.8	-1.0	-0.0	2.8	-1.0
Length of working week for main job	0.4	0.5	1.3	-0.3	-1.2	-0.8	-0.5	-0.0
Exposure to tobacco smoke at home	0.8	0.9	2.6	0.7	-0.1	-0.9	-0.6	1.6
Breastfed as a baby	0.3	0.4	0.5	0.6	-0.6	0.7	-0.4	-0.7
Tense / ‘highly strung’	0.4	0.7	2.0	1.1	-0.2	-1.4	-0.4	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.1	0.1	-0.4	0.0	0.4	-0.3	-0.1
Hair/balding pattern: Pattern 4	1.6	3.9	9.8	1.6	0.8	-1.3	2.2	-3.1
Birth weight of first child	1.9	3.4	6.6	2.6	0.6	-2.3	1.6	-1.5
Peak expiratory flow (PEF)	1.6	3.7	7.9	2.8	0.6	-1.6	2.2	-1.7
Pulse wave reflection index	0.6	0.8	1.6	-0.0	1.3	0.9	-1.1	0.5
Ever highly irritable/argumentative for 2 days	1.2	1.5	3.3	0.4	1.8	0.4	0.6	1.8
Loud music exposure frequency	2.1	2.3	5.1	-2.3	-1.8	-0.5	-1.7	0.2
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.6	-0.7	-0.9	-0.1	0.1	-1.6
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.4	1.2	0.6	0.4	0.4	0.7
Blood clot in the leg (DVT)	0.5	0.7	2.4	1.6	0.9	-0.4	-0.4	-0.0
Medication: Paracetamol	0.2	0.3	1.2	0.1	1.1	-0.5	0.1	-0.4
Headache pain in last month	0.5	0.8	2.9	0.1	0.6	-1.7	0.7	0.7
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	3.1	1.8	0.1	-0.3	1.5	-1.5
Glaucoma (self-reported)	2.4	2.8	5.2	-1.6	-0.6	1.2	-2.3	2.1
Gout (self-reported)	4.3	5.8	10.6	-3.3	-3.0	2.1	-2.2	0.5
Hypothyroidism/myxoedema (self-reported)	0.4	0.9	2.1	-1.4	-0.8	0.7	-0.9	-0.5
Medication: Amlodipine	0.5	0.7	1.6	0.1	-0.3	-0.9	-0.9	1.3
Medication: Ventolin 100micrograms inhaler	3.2	4.1	9.3	-0.2	1.2	1.1	-3.0	2.9
Birth weight	2.3	5.1	8.8	2.6	0.5	-3.0	2.4	-2.0
Chronic bronchitis/emphysema (mother)	1.5	1.7	4.5	-0.3	-0.1	1.8	-1.0	2.1
High blood pressure (siblings)	2.3	3.4	7.3	-2.2	-1.1	1.0	-2.7	1.6
Forced vital capacity (FVC), Best measure	0.8	2.9	7.3	0.9	-2.4	0.7	2.7	-0.0
Body fat percentage	1.6	6.2	18.9	-4.3	-1.6	-0.3	-0.0	-3.1
Leg fat percentage (right)	0.9	3.2	11.5	-3.4	-0.2	-1.0	-1.4	-1.2
Arm fat-free mass (right)	0.1	0.7	2.8	0.3	0.0	-1.7	0.5	0.4
Exposure to tobacco smoke outside home	0.4	0.5	1.6	0.1	0.2	-0.8	-0.3	1.2
Comparative body size at age 10	0.3	0.9	2.7	-0.6	-1.6	-0.0	-0.9	0.9
Number of full brothers	0.8	1.0	2.2	-0.2	1.5	0.6	-1.2	0.9
Worry too long after embarrassment	0.7	1.2	2.4	-1.0	-0.8	0.5	-1.6	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.4	-0.3	-0.2	-0.3	-0.2	-0.6
Wheeze or whistling in the chest in last year	2.2	3.9	10.8	-0.6	1.1	0.8	-2.6	3.3
Number of children fathered	1.1	1.2	2.1	1.3	0.4	-1.4	1.3	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	3.0	0.5	1.7	0.5	-0.2	1.1
Age at first live birth	1.5	2.6	6.7	-1.6	-1.3	2.6	-1.1	0.8
Pulse wave peak to peak time	0.8	1.0	3.5	0.8	0.2	-0.6	1.9	-0.6
Health satisfaction	0.7	0.9	2.4	-1.6	-1.4	-0.3	-0.1	-0.1
Shortness of breath walking on level ground	0.8	0.9	2.5	-1.6	-1.1	0.4	-0.5	0.6
Qualifications: College or University degree	0.7	2.2	4.0	-1.1	-1.9	2.0	0.4	1.4
Eye problems/disorders: None of the above	0.5	0.6	0.9	0.6	0.9	-0.7	0.6	-0.9
Mouth/teeth dental problems: Loose teeth	2.4	2.9	10.8	-0.1	3.3	1.3	0.6	1.2
Emphysema/chronic bronchitis	2.1	2.4	4.4	-0.8	1.4	1.3	-1.8	2.1
Medication for pain relief, constipation, heartburn	0.2	0.3	0.7	-0.8	-0.5	-0.0	-0.1	-0.7
Neck or shoulder pain in last month	1.4	2.0	4.4	1.0	1.5	-1.5	-0.3	2.1
Medication: Blood pressure	1.3	2.2	4.4	-1.8	0.2	0.7	-2.1	1.7
Angina (self-reported)	0.7	0.9	2.6	0.9	1.6	-0.0	1.0	-0.1
Migraine (self-reported)	0.1	0.1	0.3	0.2	0.6	0.1	0.0	-0.1
Medication: Ibuprofen	0.3	0.4	0.6	0.7	0.7	-0.3	0.2	0.8
Medication: Allopurinol	5.1	6.7	15.4	-3.9	-3.2	2.1	-1.9	-0.1
Medication: Omeprazole	0.2	0.2	0.7	0.2	0.0	-0.4	-0.2	0.8
Medication: Seretide 50 evohaler	0.7	0.8	2.4	-1.6	0.1	0.2	-1.2	-0.1
Mean time to correctly identify matches	3.4	6.5	11.7	-3.4	-3.3	1.2	-2.9	-0.5
Heart disease (mother)	0.2	0.2	0.3	0.4	0.4	-0.5	-0.6	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	2.6	0.2	1.3	1.6	-0.1	-0.5
Whole body fat mass	1.0	4.3	13.5	-3.7	-1.5	-0.6	0.1	-2.4
Leg fat mass (right)	0.7	2.7	8.9	-3.0	-0.7	-1.2	-0.2	-1.6
Arm predicted mass (right)	0.1	0.7	2.6	0.4	-0.0	-1.6	0.5	0.5
Pulse rate, automated reading	1.8	5.7	15.3	-2.4	-0.4	0.5	-3.9	2.7
Alcohol intake frequency.	0.3	0.6	2.0	-1.4	-1.0	0.1	-0.0	0.0
Comparative height size at age 10	0.4	2.2	5.5	2.3	0.1	0.3	2.3	-0.4
Number of full sisters	1.0	1.2	5.5	0.2	2.4	-0.0	0.4	0.6
Suffer from ‘nerves’	0.5	0.8	1.6	-0.3	-1.2	-0.2	-1.3	1.0
Overall health rating	0.8	1.8	3.5	-1.0	1.4	0.5	-1.9	1.5
Chest pain or discomfort	0.9	1.3	4.3	-0.5	0.1	0.8	-1.1	2.1
Had major operations	1.1	1.2	3.3	-0.8	-1.8	1.4	-0.1	-0.6
Age at last live birth	0.6	0.8	2.1	-0.7	-1.2	1.4	-0.1	0.2
Family relationship satisfaction	1.1	1.4	4.0	0.3	1.1	1.1	-0.7	2.0
Leg pain on walking	0.7	0.8	3.5	-0.0	-0.4	-1.9	0.2	-0.6
Qualifications: NVQ or HND or HNC or equivalent	2.3	2.8	6.8	1.4	1.1	-0.3	2.0	-2.6
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.3	-0.6	-1.1	-0.5	-0.4	-0.7
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.9	-1.0	-0.7	0.4	-0.1	-0.9
Medication: Aspirin	0.4	0.6	2.1	0.0	-0.0	0.8	-0.2	1.5
Supplements: Vitamin C	0.6	0.7	1.4	-0.4	-0.9	-1.2	1.0	-0.5
Knee pain experienced in last month	1.4	2.2	5.3	1.5	1.3	-1.2	0.5	2.3
Hypertension (Self-reported)	1.7	4.7	11.2	-1.4	-0.1	0.9	-3.3	3.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	1.4	-0.0	1.2	0.4	-0.2	-0.3
Illnesses of father: Heart disease	0.2	0.3	0.9	-0.6	0.1	0.5	-0.1	-1.0
Illnesses of siblings: Diabetes	1.3	1.6	3.1	-1.4	-0.6	1.2	-1.7	-1.0
Smoking status: Previous	0.1	0.1	0.2	-0.1	-0.5	-0.4	-0.2	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	5.6	0.5	-1.2	0.1	2.4	-1.2
Whole body fat-free mass	0.1	0.8	2.3	0.2	-0.8	-1.5	0.9	0.0
Leg fat-free mass (right)	0.5	2.5	5.2	-1.3	-2.3	-1.1	1.5	-1.5
Arm fat percentage (left)	1.6	6.4	15.7	-4.0	-2.3	-0.6	0.5	-3.3
Average weekly red wine intake	0.7	1.1	2.2	-0.4	-1.2	-1.5	1.1	-0.6
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.7	-1.1	0.7	-0.6	-0.6	1.3
Mood swings	0.5	0.9	2.1	1.1	0.3	-1.4	0.7	-0.9
Loneliness, isolation	0.1	0.1	0.2	0.1	0.4	-0.2	0.4	0.4
Long-standing illness, disability or infirmity	1.5	2.3	6.6	0.5	1.1	0.5	-1.8	2.6
Ever had bowel cancer screening	0.5	0.6	1.5	0.4	0.4	-0.2	-1.2	1.1
Diabetes diagnosed by doctor	0.3	0.4	1.1	1.0	0.5	-0.0	-0.9	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.2	-0.5	-1.1	0.3	-0.1	0.7
Friendships satisfaction	1.0	1.2	2.4	-1.2	0.5	1.1	-0.9	1.5
Qualifications: nursing, teaching	0.6	0.9	1.5	-1.2	-0.7	0.8	-1.2	0.8
Commuting to job workplace: Walk	0.3	0.4	1.4	0.3	0.3	0.1	1.2	-0.4
Eye problems/disorders: Cataract	0.4	0.5	1.1	1.0	0.1	0.8	0.6	0.5
Mouth/teeth dental problems: Mouth ulcers	0.0	0.1	0.1	0.1	0.3	-0.2	-0.4	-0.3
Medication for cholesterol	0.4	0.7	2.6	-1.6	-0.6	0.4	-0.2	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	3.5	0.3	1.9	-0.4	-0.8	0.8
Back pain experienced in last month	1.8	2.6	7.5	0.2	2.7	0.7	-0.4	2.2
Mineral and other dietary supplements	0.4	0.5	1.5	-1.2	-0.4	-0.5	-0.6	0.4
Breast cancer (self-reported)	1.1	1.4	2.7	1.4	-0.7	-1.6	1.0	-0.8
Asthma (self-reported)	1.9	3.8	10.4	-1.5	0.1	-0.0	-3.2	2.6
Osteoporosis (self-reported)	1.8	2.3	4.9	-1.6	0.9	1.0	-2.2	1.5
Osteoarthritis (self-reported)	0.3	0.3	1.0	-0.3	0.3	-0.4	-0.5	-1.0
Medication: Aspirin	0.5	0.7	2.1	-0.0	0.4	1.0	-0.2	1.5
Medication: Gliclazide	1.2	1.4	3.6	-1.3	-0.6	0.7	-1.9	0.8
Illnesses of father: None of the above (group 1)	0.8	1.0	2.6	1.6	1.4	0.0	0.6	0.5
Smoking status: Current	0.3	0.5	1.5	-0.4	1.2	-0.4	-0.6	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	2.9	6.4	2.5	-0.1	-1.8	1.1	-1.9
Whole body water mass	0.1	0.8	2.6	0.3	-0.7	-1.6	1.0	-0.0
Leg predicted mass (right)	0.5	2.5	5.3	-1.3	-2.3	-1.0	1.4	-1.5
Arm fat mass (left)	0.9	3.5	9.5	-3.1	-1.8	-1.0	0.2	-2.0
Number of self-reported non-cancer illnesses	1.9	3.3	8.5	0.4	1.6	0.2	-2.3	2.9
Average weekly champagne plus white wine intake	1.1	1.6	4.9	0.4	2.2	1.6	-0.1	-0.3
Miserableness	0.2	0.4	0.8	-0.7	-0.1	-0.2	-0.8	0.9
Guilty feelings	0.4	0.6	1.6	-0.7	0.3	-0.6	0.8	-1.2
Wears glasses or contact lenses	0.6	0.7	1.4	0.7	-0.9	-0.6	-1.2	0.5
Ever taken oral contraceptive pill	0.8	0.9	1.5	1.0	1.2	-1.1	-0.0	1.0
Hearing aid user	0.8	0.9	2.5	-0.4	-1.6	1.0	-0.4	-0.8
Mother’s age at death	0.6	0.8	2.0	-1.4	0.1	0.7	-0.1	-1.2
Financial situation satisfaction	0.7	0.8	1.5	-1.2	-1.0	0.7	-0.7	0.9
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.0	0.1	-0.4	-1.0	0.2	-0.7
Commuting to job workplace: Public transport	0.4	0.5	1.0	-0.8	0.7	1.0	-0.3	0.4
Eye problems/disorders: Glaucoma	2.0	2.3	5.7	-2.4	-1.2	0.8	-1.6	1.1
Medication: Blood pressure	1.5	2.8	6.8	0.2	0.3	1.0	-2.5	2.6
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.1	1.1	1.0	-1.4	0.3	0.3
Supplements: Fish oil (including cod liver oil)	0.4	0.6	2.0	0.6	0.6	1.4	-0.3	0.3
High cholesterol (Self-reported)	1.1	1.9	5.3	1.4	2.3	0.1	0.1	1.6
Medication: Bendroflumethiazide	2.2	3.4	8.1	-1.7	-0.9	1.5	-2.9	1.8
Medication: Paracetamol	0.3	0.4	0.7	-0.3	0.9	-0.8	-0.7	0.2
Medication: Lisinopril	0.1	0.1	0.3	-0.5	-0.1	0.3	-0.5	-0.0
Medication: Atorvastatin	0.9	1.1	3.6	0.4	0.5	0.4	-1.2	1.9
Illnesses of father: High blood pressure	0.9	1.1	1.6	-1.0	-1.2	-0.3	-1.2	-1.3
Alcohol drinker status: Never	0.6	0.7	1.3	1.2	1.0	-0.5	0.8	0.6
Ever smoked	0.1	0.1	0.2	-0.4	-0.5	-0.4	-0.1	0.1
Basal metabolic rate	0.2	0.9	2.1	-0.5	-1.1	-1.5	0.9	-0.5
Leg fat percentage (left)	0.9	3.4	12.0	-3.5	-0.3	-1.1	-1.4	-1.4
Arm fat-free mass (left)	0.1	0.7	3.0	-0.1	-0.3	-1.7	0.1	0.5
Number of operations (self-reported)	0.7	1.0	3.8	-0.9	-0.2	0.7	-1.9	0.2
Average weekly beer plus cider intake	3.2	4.6	10.5	3.2	1.7	-1.5	2.6	-0.5
Irritability	0.3	0.6	2.0	-0.1	-0.2	-1.4	-0.1	0.9
Risk taking	1.2	1.8	7.6	-0.0	-1.0	-2.8	0.3	0.2
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.5	-0.1	0.9	-0.0	-1.3	1.6
Fractured/broken bones in last 5 years	2.1	2.7	7.8	-1.7	-0.6	0.8	-2.8	1.3
Age started oral contraceptive pill	0.5	0.7	1.3	-0.9	-0.8	0.8	-1.1	0.4
Diastolic blood pressure, automated reading	2.1	6.4	17.0	-3.2	-1.4	-0.1	-4.1	1.7
Ever depressed for a whole week	1.0	1.2	2.7	0.4	0.9	-1.1	-1.1	1.6
Unable to work because of sickness or disability	0.4	0.5	0.8	0.8	0.8	-0.0	0.9	-0.6
Commuting to job workplace: Cycle	0.9	1.0	2.9	1.7	0.1	-0.4	1.4	0.3
Myopia	0.6	0.8	2.7	-0.1	-0.6	-0.0	-1.0	1.7
Vascular/heart problems diagnosed by doctor	2.0	5.3	12.3	1.5	0.3	-0.8	3.4	-3.5
Cholesterol lowering medication	2.5	3.7	10.2	3.2	2.5	-0.4	1.1	0.9
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.2	1.1	0.7	-0.5	0.1	0.2
Pain experienced in last month	1.4	2.3	4.4	-1.4	-1.6	1.4	-0.7	-2.1
Supplements: Calcium	0.3	0.3	0.7	-0.0	-0.5	0.4	0.5	0.8
Basal cell carcinoma (self-reported)	3.2	3.8	6.6	2.6	-0.3	-2.1	2.5	-1.3
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.8	1.4	0.1	-0.8	1.3	0.4
Deep venous thrombosis (DVT) (self-reported)	1.0	1.2	4.3	2.1	1.0	-0.7	0.2	-0.7
Heart disease (siblings)	0.6	0.8	1.8	1.3	-0.4	-0.7	1.0	-0.7
Alcohol drinker status: Previous	1.0	1.2	2.6	-1.6	-1.5	0.7	-0.2	-0.6
Pack years of smoking	4.0	5.8	17.7	-1.2	0.8	0.1	-4.2	3.1
Impedance of whole body	0.4	2.2	4.0	-1.7	0.0	2.0	0.7	-1.9
Leg fat mass (left)	0.7	2.9	9.1	-3.0	-0.8	-1.4	-0.3	-1.7
Arm predicted mass (left)	0.2	0.8	3.1	0.1	-0.2	-1.8	-0.0	0.9