Hub : Genes

FAM13A

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.1160 0.0460 1.0e-03 0.002 NA 0.009 NA 0.007 2.3e-01 NA 6.9e-02 NA 8.3e-02
2 ROSMAP Brain Pre-frontal Cortex 0.1229 0.0285 1.3e-11 0.131 0.121 0.123 0.125 0.127 1.8e-16 2.5e-15 1.4e-15 8.9e-16 5.9e-16
3 TCGA Breast Invasive Carcinoma 0.0288 0.0186 3.6e-03 0.022 0.011 0.011 NA 0.013 2.0e-05 1.9e-03 1.7e-03 NA 8.8e-04
4 TCGA Head and Neck Squamous Cell Carcinoma 0.0364 0.0208 5.6e-03 0.018 0.006 0.001 NA 0.009 3.7e-03 6.1e-02 2.4e-01 NA 2.8e-02
5 TCGA Brain Lower Grade Glioma 0.0567 0.0273 1.4e-03 0.004 0.019 0.002 NA 0.000 1.1e-01 2.4e-03 1.9e-01 NA 2.8e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 1.0 1.6 3.7 -1.2 -1.4 0.7 -1.9 0.6
Bipolar Disorder or Schizophrenia 0.5 1.3 2.4 -1.3 -0.8 1.6 -0.9 1.0
Depressed Affect (Nagel 2018) 0.2 0.5 1.2 0.1 0.9 -0.3 -0.4 1.1
Depression (Nagel 2018) 0.2 0.3 0.9 -0.2 0.3 -0.6 -0.0 1.0
Intelligence (Savage-Jansen 2018) 0.1 0.4 1.1 0.1 -0.6 1.1 0.6 -0.6
Neuroticism (Nagel 2018) 0.3 0.6 2.4 -0.3 0.2 -0.2 -0.7 1.6
Schizophrenia (2018) 0.3 0.7 2.1 -0.7 0.1 1.5 0.3 0.8
Schizophrenia vs Biploar Disorder 1.1 1.5 4.8 1.4 -0.1 -0.3 2.2 -0.8
Worry (Nagel 2018) 0.4 0.9 3.3 -0.3 -0.2 -0.1 -1.0 1.8
Alzheimer’s Disease (in mother) 1.3 1.5 4.5 -0.6 1.1 0.7 -1.0 2.1
Alzheimer’s Disease (in father) 0.2 0.2 0.7 -0.1 0.5 -0.8 0.4 -0.1
Alzheimer’s Disease (including proxy) 0.5 0.8 1.6 -0.9 0.4 0.5 -1.0 1.3
Crohns Disease (2017) 1.4 3.1 5.0 -2.0 -2.0 1.5 -2.2 -0.7
Irritable Bowel Disease (IBD) 1.3 3.1 5.0 -2.2 -1.7 1.4 -1.7 -1.7
Ulcerative Colitis (UC) 1.4 2.6 4.9 -2.2 -1.2 1.2 -0.8 -2.1
Major Depression (MDD) 0.9 1.1 2.9 -1.7 -0.9 0.5 -1.1 0.5
Reaction Time 3.6 6.8 16.1 -3.6 -4.0 0.1 -2.1 -0.9
Verbal and Numeric Reasoning (VNR) 0.4 1.0 2.2 -1.0 -1.5 1.2 0.1 -0.5
Breast Cancer 1.2 2.9 7.1 -0.6 1.6 0.9 -2.0 2.7
Ovarian Cancer 0.3 0.4 0.8 0.3 0.9 0.7 -0.6 0.6
Prostate Cancer 0.2 0.3 0.5 0.4 0.1 -0.7 -0.4 0.7
Age at First Birth 0.2 0.3 1.0 -0.5 -0.4 0.2 -1.0 -0.0
Bipolar Disorder (2011) 1.7 1.7 4.1 -1.1 -0.7 0.3 -2.0 1.5
Body Mass Index (BMI) (2010) 1.0 1.3 3.8 -2.0 -1.1 0.2 0.1 -1.3
Coronary Artery Disease (CAD) 0.9 1.1 4.2 0.4 0.9 -0.0 -0.6 2.1
Crohns Disease (2012) 0.7 1.2 3.0 -0.4 -1.5 1.7 -0.7 -0.1
Mean Putamen Volume 0.6 0.6 2.0 0.7 -0.3 -0.7 1.4 0.1
Fasting Glucose 0.6 0.7 1.5 -1.2 -1.2 0.0 0.4 -0.7
HbA1C 0.2 0.2 0.4 0.4 0.5 -0.6 -0.5 0.2
HDL Cholesterol 1.9 3.2 6.9 -1.1 -2.6 0.7 1.1 -2.5
LDL Cholesterol 0.3 0.4 1.1 0.8 0.5 -0.1 -0.3 1.1
Lupus 0.7 1.1 3.9 0.6 0.0 0.9 0.5 2.0
Neuroticism (2016) 0.5 0.7 1.8 -0.2 -0.7 -1.0 0.5 -1.3
Primary Biliary Cirrhosis 0.1 0.1 0.4 0.6 -0.1 0.1 -0.1 0.1
Rheumatoid Arthritis 0.6 0.8 1.7 -1.1 -1.3 -0.7 0.7 -0.2
Schizophrenia (2014) 0.7 1.5 5.4 -0.3 0.1 2.3 -0.2 1.4
Triglycerides 1.2 1.9 4.6 -0.9 0.4 1.1 -2.2 1.7
Type 2 Diabetes (T2D) (2012) 0.9 1.0 2.2 1.5 1.5 0.7 0.2 0.2
Ulcerative Colitis 0.9 1.3 2.3 -1.1 -1.1 1.5 0.6 -1.1
Blood Eosinophil Count 1.4 11.0 15.9 -4.0 -0.8 3.9 -3.9 2.9
Blood Platelet Count 0.6 6.4 15.6 -3.5 -4.0 -1.5 0.1 1.4
Blood Red Count 0.5 5.0 13.6 -1.3 1.0 2.7 -3.7 1.3
Blood White Count 0.9 6.7 13.8 -2.8 -1.4 1.4 -2.8 3.7
Heel T-Score 0.4 3.0 10.0 -2.1 -3.2 0.2 -0.6 0.3
BMI 0.7 4.1 9.4 -3.1 -2.4 -1.1 -0.2 -2.0
Height 0.2 4.5 12.4 2.3 -0.2 -0.9 3.5 -1.9
Waist Hip Ratio (WHR) 4.6 20.8 56.8 6.1 2.9 0.4 -0.9 7.5
Systolic Blood Pressure 1.4 7.1 20.2 -0.6 0.7 1.3 -3.6 4.5
Smoking Status 0.5 1.2 3.2 0.2 1.5 -0.2 -0.7 1.8
Allergy or Eczema 0.4 1.1 4.1 2.0 1.1 0.2 0.1 0.7
Cardiovascular Disease 1.1 3.5 9.1 -0.9 0.8 1.5 -2.2 3.0
Hypothyroidism (self reported) 0.3 0.7 1.9 -1.1 0.0 1.4 -0.3 -0.3
Respiratory disease 1.0 2.3 5.2 -0.9 0.2 -1.2 -2.3 2.0
Type 2 Diabetes (T2D) (2018) 0.2 0.4 1.1 1.1 -0.0 -0.8 -0.6 0.2
Lung FEV1/FVC ratio 11.2 56.9 98.2 7.4 6.5 -9.9 3.8 -8.6
Lung FVC 1.0 5.3 15.1 1.1 -1.1 3.0 0.4 3.9
Neuroticism 0.5 1.2 2.5 -0.8 -0.1 -1.0 -1.3 1.6
Chronotype (morning person) 2.2 5.1 9.7 -3.1 -1.9 1.9 -2.9 -0.6
Hair Pigment 0.2 4.5 11.3 3.4 0.3 -1.4 1.9 -2.4
Tanning 0.0 0.4 1.4 0.1 -0.3 0.1 0.6 -1.2
Hand grip strength (left) 0.7 1.8 2.7 1.6 1.6 -1.6 1.1 0.4
Number of treatments/medications taken 0.3 0.5 1.2 0.4 0.1 -0.8 -1.1 0.9
Average weekly spirits intake 0.2 0.3 0.5 -0.7 -0.7 -0.5 -0.3 -0.1
Sensitivity / hurt feelings 0.3 0.6 1.5 -1.2 -1.1 -0.2 0.3 0.1
Frequency of depressed mood in last 2 weeks 0.2 0.3 1.4 -0.3 0.3 -1.2 -0.0 0.1
Hearing difficulty/problems: Yes 0.2 0.4 0.8 0.4 -0.9 -0.9 -0.1 -0.0
Relative age of first facial hair 0.5 1.0 2.4 -0.9 -1.2 -0.6 -1.6 0.2
Other serious medical condition/disability diagnosed by doctor 0.1 0.2 0.4 0.5 -0.2 -0.1 0.2 0.6
Ever used hormone-replacement therapy (HRT) 2.5 3.1 9.3 -1.8 -0.5 1.0 -3.0 1.3
Ever had hysterectomy (womb removed) 0.8 0.9 3.6 0.5 0.6 -0.6 -0.2 -1.9
Systolic blood pressure, automated reading 1.1 3.1 9.0 -0.9 0.4 0.5 -3.0 2.3
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.5 -0.1 0.3 0.7 -0.6 -0.4
Angina 0.7 1.0 3.4 0.9 1.8 0.1 0.8 0.1
Medication for hormone replacement therapy 0.8 0.8 2.9 -0.7 -1.7 0.2 0.8 -0.5
Vitamin and mineral supplements 0.5 0.6 1.8 -1.0 0.2 0.5 -1.3 -0.4
Supplements: Zinc 0.3 0.3 0.8 0.7 -0.2 0.1 0.9 -0.0
Medication: Co-codamol 1.6 1.8 4.3 -1.3 -1.0 2.1 -1.0 1.1
Medication: Metformin 0.4 0.5 2.2 -0.1 0.2 0.4 -1.5 0.3
Diabetes (father) 0.4 0.5 1.1 1.0 -0.3 -0.7 0.6 -0.7
Diabetes (mother) 0.1 0.1 0.3 -0.3 0.1 -0.5 -0.3 0.4
Severe depression (siblings) 0.3 0.3 0.8 0.2 0.4 0.9 0.4 0.8
Pack years adult smoking proportion 3.5 5.3 16.3 -1.2 1.0 -0.0 -4.0 2.8
Impedance of leg (right) 0.3 1.4 5.3 0.2 2.3 1.1 -0.5 0.4
Leg fat-free mass (left) 0.4 2.3 5.0 -1.4 -2.2 -0.9 1.3 -1.4
Trunk fat percentage 2.0 8.0 24.0 -4.9 -2.3 0.5 -0.1 -3.2
Hand grip strength (right) 0.7 1.9 3.9 1.9 1.0 -1.0 2.0 -0.1
Townsend deprivation index at recruitment 0.2 0.2 0.6 -0.4 0.8 -0.6 -0.3 -0.1
Current tobacco smoking 0.4 0.7 2.3 -0.3 1.5 -0.5 -0.7 0.5
Average weekly fortified wine intake 0.2 0.3 1.0 1.0 0.5 -0.2 0.2 0.1
Maternal smoking around birth 1.8 2.6 7.0 -1.2 0.8 0.6 -1.9 2.6
Fed-up feelings 1.3 2.4 4.7 -0.8 1.4 0.0 -2.2 2.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.5 -0.7 -0.6 -0.6 -0.5 0.2
Relative age voice broke 0.9 1.3 2.6 -0.9 -0.8 1.6 -1.2 -1.0
Taking other prescription medications 0.6 1.0 2.2 0.4 0.5 -1.1 -1.5 1.0
Age when periods started (menarche) 0.5 1.1 3.2 -0.0 -1.4 -1.8 0.5 -0.3
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 2.3 0.5 0.3 0.4 -1.0 1.5
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.4 -0.1 -0.4 0.0 -0.5 0.6
Tinnitus: Yes, but not now, but have in the past 1.5 1.6 4.3 2.1 1.3 -0.5 1.4 -0.3
Qualifications: CSEs or equivalent 0.4 0.5 1.8 -1.3 0.3 -0.5 0.2 -0.7
Serious illness, injury or assault to yourself 1.4 1.7 4.5 2.1 1.4 -1.1 0.8 0.6
High blood pressure 2.1 5.8 13.9 -1.9 -0.4 0.9 -3.7 3.3
Hayfever, allergic rhinitis or eczema 0.9 1.9 5.5 2.3 1.8 -0.1 0.4 0.7
Multivitamins +/- minerals 0.2 0.3 0.8 0.7 -0.3 0.3 0.9 0.1
Stomach or abdominal pain in last month 0.5 0.7 1.7 -0.1 -0.3 1.3 -0.9 0.9
Supplements: Glucosamine 0.4 0.5 2.2 1.5 0.3 -0.0 0.1 -0.1
Diverticular disease/diverticulitis (self-reported) 0.9 1.1 3.5 -1.3 -0.4 0.0 -1.9 0.5
Medication: Atenolol 2.0 2.5 6.6 2.6 1.6 -0.5 1.2 1.2
Medication: Levothyroxine sodium 0.2 0.3 1.0 0.1 -0.5 0.2 0.7 -1.0
Sitting height 0.0 0.3 0.6 -0.5 -0.8 0.4 0.7 0.2
Chronic bronchitis/emphysema (father) 2.5 2.9 6.1 -2.5 -1.6 2.1 -1.2 0.0
High blood pressure (mother) 2.4 3.3 6.3 -2.5 -2.1 1.1 -2.1 0.7
Body mass index (BMI) 0.6 2.6 7.4 -2.7 -1.4 -1.3 -0.6 -1.1
Impedance of leg (left) 0.2 1.1 4.9 -0.1 2.2 0.8 -0.4 0.2
Leg predicted mass (left) 0.4 2.1 4.7 -1.2 -2.2 -0.9 1.3 -1.4
Trunk fat mass 1.3 5.6 17.0 -4.1 -1.9 -0.0 0.2 -2.7
Waist circumference 0.1 0.5 1.8 -0.5 -0.1 -1.3 -0.1 0.8
Number of incorrect matches in round 2.3 3.8 9.3 0.9 3.1 -1.3 -1.7 2.2
Past tobacco smoking 0.2 0.3 0.8 0.1 0.7 0.4 -0.1 -0.9
Alcohol usually taken with meals 0.4 0.7 2.8 -1.7 0.1 0.7 -0.4 -0.1
Nervous feelings 0.1 0.2 0.6 -0.3 -0.4 0.1 -0.5 0.7
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 1.7 -0.1 0.8 -0.7 -0.6 1.3
Hearing difficulty/problems with background noise 0.3 0.5 0.9 0.3 0.9 -0.8 -0.9 -0.0
Hair/balding pattern: Pattern 2 0.7 1.0 2.8 0.6 -0.1 1.2 -0.4 1.7
Had menopause 1.0 1.3 3.1 0.0 -0.1 -0.7 -1.6 1.8
Had other major operations 0.2 0.3 0.6 0.6 0.4 -0.5 -0.8 -0.2
Forced vital capacity (FVC) 0.4 1.7 3.2 0.8 -1.7 1.1 1.8 0.8
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 1.1 -0.4 -0.2 -0.0 -0.8 1.0
Ever unenthusiastic/disinterested for a whole week 1.2 1.5 7.0 0.0 -0.6 -2.6 0.3 -0.3
Qualifications: None of the above 0.7 1.6 4.0 2.0 1.2 -0.9 1.0 -0.8
Financial difficulties in last 2 years 1.2 1.7 3.6 -1.6 -1.3 0.7 -0.5 1.9
Mouth/teeth dental problems 0.5 0.8 2.8 -0.4 -1.7 -0.5 0.5 -0.8
Heart attack 0.6 0.8 1.8 1.2 0.1 -0.7 1.3 0.4
Allergy 0.9 2.1 4.1 -1.3 -1.6 -0.3 1.5 -2.0
Pain all over the body in last month 0.2 0.2 0.7 0.1 0.1 -0.7 -0.2 -0.8
Diabetes (self-reported) 0.3 0.5 1.0 0.8 0.8 -0.0 -1.0 0.3
Hayfever/allergic rhinitis (self-reported) 2.9 3.8 8.5 2.9 2.5 -0.9 1.5 -1.0
Medication: Ramipril 1.5 1.9 4.0 -1.3 0.1 0.9 -2.0 1.8
Medication: Simvastatin 1.0 1.4 5.0 0.7 1.0 0.5 -0.5 2.2
Fluid intelligence score 0.5 1.1 3.1 -0.7 -1.8 1.3 0.4 0.1
Illnesses of siblings 2.3 3.3 7.1 2.3 0.5 -1.3 2.7 -1.4
Neuroticism score 0.4 0.9 1.2 -1.0 -0.7 -0.9 -1.1 1.0
Weight 0.6 2.8 5.3 -2.3 -1.8 -1.3 0.6 -1.7
Impedance of arm (right) 1.0 4.8 11.6 -1.9 -1.4 1.8 1.8 -3.4
Arm fat percentage (right) 1.4 5.5 13.4 -3.7 -2.0 -0.8 0.3 -3.1
Trunk fat-free mass 0.2 1.2 3.0 1.3 0.1 -1.7 0.7 0.9
Hip circumference 1.3 5.5 12.5 -3.5 -2.1 -0.9 0.7 -3.1
Time employed in main current job 0.8 1.0 1.6 1.3 1.3 -0.5 1.1 0.4
Alcohol intake versus 10 years previously 0.4 0.7 1.3 -1.0 -1.1 -0.7 0.6 0.2
Father’s age at death 0.7 1.0 2.2 1.3 1.1 -0.0 -0.1 1.5
Worrier / anxious feelings 0.2 0.4 1.1 -0.8 -0.6 -1.0 -0.0 -0.4
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.9 1.9 -1.4 -0.7 -0.1 -1.1 0.9
Falls in the last year 1.1 1.4 4.7 -2.2 -0.7 0.9 -1.0 -0.3
Hair/balding pattern: Pattern 3 1.0 1.4 2.7 -0.9 -1.1 1.6 -1.4 -0.7
Number of live births 1.6 2.3 5.1 2.3 1.1 -0.2 1.5 -1.6
Forced expiratory volume in 1-second (FEV1) 0.8 2.8 6.5 2.1 -0.4 -1.0 2.5 -1.4
Pulse rate 1.6 2.6 6.2 -2.1 -0.9 0.2 -2.5 1.3
Happiness 0.6 0.7 2.3 -1.5 -0.3 -1.0 -0.4 -0.1
Noisy workplace 1.1 1.3 2.5 1.6 1.0 -1.4 0.8 -0.6
Qualifications: A levels/AS levels or equivalent 0.7 1.5 5.1 -0.8 -2.3 0.7 0.6 -0.9
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.1 1.8 0.5 -1.3 -0.9 1.0 -1.2
Mouth/teeth dental problems: Dentures 0.4 0.7 1.5 -0.5 0.8 0.9 -1.2 0.2
Asthma 1.8 3.5 9.0 -1.6 -0.1 0.2 -3.0 2.5
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 0.9 0.4 0.7 0.3 -0.1 0.9
Medication: Cholesterol lowering 0.6 0.9 1.7 -1.3 -0.0 0.6 -1.0 1.2
Depression (self-reported) 0.3 0.4 0.7 0.7 0.4 -0.8 0.0 -0.7
Medication: Lansoprazole 0.2 0.2 0.5 0.3 0.7 0.1 0.2 0.7
Prospective memory result 0.7 0.9 1.4 -0.8 0.9 -0.7 -1.1 -1.2
Lung cancer (father) 0.4 0.4 0.9 0.9 0.1 -0.9 0.4 0.4
Illnesses of mother 2.0 2.5 4.9 1.2 -0.0 -1.9 1.6 -2.2
Forced expiratory volume in 1-second (FEV1), Best measure 1.5 4.7 11.1 2.0 -0.7 -1.6 3.3 -2.2
Pulse wave Arterial Stiffness index 0.6 0.7 2.5 -0.7 -0.2 0.5 -1.6 0.4
Impedance of arm (left) 1.3 6.2 12.9 -2.1 -1.8 2.4 2.3 -3.6
Arm fat mass (right) 0.8 3.2 8.8 -3.0 -1.5 -1.0 0.3 -2.0
Trunk predicted mass 0.2 1.2 3.2 1.2 0.1 -1.8 0.6 1.1
Standing height 0.2 2.1 7.7 0.8 -1.0 -0.0 2.8 -1.0
Length of working week for main job 0.4 0.5 1.3 -0.3 -1.2 -0.8 -0.5 -0.0
Exposure to tobacco smoke at home 0.8 0.9 2.6 0.7 -0.1 -0.9 -0.6 1.6
Breastfed as a baby 0.3 0.4 0.5 0.6 -0.6 0.7 -0.4 -0.7
Tense / ‘highly strung’ 0.4 0.7 2.0 1.1 -0.2 -1.4 -0.4 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.0 0.1 0.1 -0.4 0.0 0.4 -0.3 -0.1
Hair/balding pattern: Pattern 4 1.6 3.9 9.8 1.6 0.8 -1.3 2.2 -3.1
Birth weight of first child 1.9 3.4 6.6 2.6 0.6 -2.3 1.6 -1.5
Peak expiratory flow (PEF) 1.6 3.7 7.9 2.8 0.6 -1.6 2.2 -1.7
Pulse wave reflection index 0.6 0.8 1.6 -0.0 1.3 0.9 -1.1 0.5
Ever highly irritable/argumentative for 2 days 1.2 1.5 3.3 0.4 1.8 0.4 0.6 1.8
Loud music exposure frequency 2.1 2.3 5.1 -2.3 -1.8 -0.5 -1.7 0.2
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 2.6 -0.7 -0.9 -0.1 0.1 -1.6
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.4 1.2 0.6 0.4 0.4 0.7
Blood clot in the leg (DVT) 0.5 0.7 2.4 1.6 0.9 -0.4 -0.4 -0.0
Medication: Paracetamol 0.2 0.3 1.2 0.1 1.1 -0.5 0.1 -0.4
Headache pain in last month 0.5 0.8 2.9 0.1 0.6 -1.7 0.7 0.7
Medication for cholesterol, blood pressure or diabetes 0.9 1.5 3.1 1.8 0.1 -0.3 1.5 -1.5
Glaucoma (self-reported) 2.4 2.8 5.2 -1.6 -0.6 1.2 -2.3 2.1
Gout (self-reported) 4.3 5.8 10.6 -3.3 -3.0 2.1 -2.2 0.5
Hypothyroidism/myxoedema (self-reported) 0.4 0.9 2.1 -1.4 -0.8 0.7 -0.9 -0.5
Medication: Amlodipine 0.5 0.7 1.6 0.1 -0.3 -0.9 -0.9 1.3
Medication: Ventolin 100micrograms inhaler 3.2 4.1 9.3 -0.2 1.2 1.1 -3.0 2.9
Birth weight 2.3 5.1 8.8 2.6 0.5 -3.0 2.4 -2.0
Chronic bronchitis/emphysema (mother) 1.5 1.7 4.5 -0.3 -0.1 1.8 -1.0 2.1
High blood pressure (siblings) 2.3 3.4 7.3 -2.2 -1.1 1.0 -2.7 1.6
Forced vital capacity (FVC), Best measure 0.8 2.9 7.3 0.9 -2.4 0.7 2.7 -0.0
Body fat percentage 1.6 6.2 18.9 -4.3 -1.6 -0.3 -0.0 -3.1
Leg fat percentage (right) 0.9 3.2 11.5 -3.4 -0.2 -1.0 -1.4 -1.2
Arm fat-free mass (right) 0.1 0.7 2.8 0.3 0.0 -1.7 0.5 0.4
Exposure to tobacco smoke outside home 0.4 0.5 1.6 0.1 0.2 -0.8 -0.3 1.2
Comparative body size at age 10 0.3 0.9 2.7 -0.6 -1.6 -0.0 -0.9 0.9
Number of full brothers 0.8 1.0 2.2 -0.2 1.5 0.6 -1.2 0.9
Worry too long after embarrassment 0.7 1.2 2.4 -1.0 -0.8 0.5 -1.6 1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.4 -0.3 -0.2 -0.3 -0.2 -0.6
Wheeze or whistling in the chest in last year 2.2 3.9 10.8 -0.6 1.1 0.8 -2.6 3.3
Number of children fathered 1.1 1.2 2.1 1.3 0.4 -1.4 1.3 -0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.8 0.9 3.0 0.5 1.7 0.5 -0.2 1.1
Age at first live birth 1.5 2.6 6.7 -1.6 -1.3 2.6 -1.1 0.8
Pulse wave peak to peak time 0.8 1.0 3.5 0.8 0.2 -0.6 1.9 -0.6
Health satisfaction 0.7 0.9 2.4 -1.6 -1.4 -0.3 -0.1 -0.1
Shortness of breath walking on level ground 0.8 0.9 2.5 -1.6 -1.1 0.4 -0.5 0.6
Qualifications: College or University degree 0.7 2.2 4.0 -1.1 -1.9 2.0 0.4 1.4
Eye problems/disorders: None of the above 0.5 0.6 0.9 0.6 0.9 -0.7 0.6 -0.9
Mouth/teeth dental problems: Loose teeth 2.4 2.9 10.8 -0.1 3.3 1.3 0.6 1.2
Emphysema/chronic bronchitis 2.1 2.4 4.4 -0.8 1.4 1.3 -1.8 2.1
Medication for pain relief, constipation, heartburn 0.2 0.3 0.7 -0.8 -0.5 -0.0 -0.1 -0.7
Neck or shoulder pain in last month 1.4 2.0 4.4 1.0 1.5 -1.5 -0.3 2.1
Medication: Blood pressure 1.3 2.2 4.4 -1.8 0.2 0.7 -2.1 1.7
Angina (self-reported) 0.7 0.9 2.6 0.9 1.6 -0.0 1.0 -0.1
Migraine (self-reported) 0.1 0.1 0.3 0.2 0.6 0.1 0.0 -0.1
Medication: Ibuprofen 0.3 0.4 0.6 0.7 0.7 -0.3 0.2 0.8
Medication: Allopurinol 5.1 6.7 15.4 -3.9 -3.2 2.1 -1.9 -0.1
Medication: Omeprazole 0.2 0.2 0.7 0.2 0.0 -0.4 -0.2 0.8
Medication: Seretide 50 evohaler 0.7 0.8 2.4 -1.6 0.1 0.2 -1.2 -0.1
Mean time to correctly identify matches 3.4 6.5 11.7 -3.4 -3.3 1.2 -2.9 -0.5
Heart disease (mother) 0.2 0.2 0.3 0.4 0.4 -0.5 -0.6 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 0.9 2.6 0.2 1.3 1.6 -0.1 -0.5
Whole body fat mass 1.0 4.3 13.5 -3.7 -1.5 -0.6 0.1 -2.4
Leg fat mass (right) 0.7 2.7 8.9 -3.0 -0.7 -1.2 -0.2 -1.6
Arm predicted mass (right) 0.1 0.7 2.6 0.4 -0.0 -1.6 0.5 0.5
Pulse rate, automated reading 1.8 5.7 15.3 -2.4 -0.4 0.5 -3.9 2.7
Alcohol intake frequency. 0.3 0.6 2.0 -1.4 -1.0 0.1 -0.0 0.0
Comparative height size at age 10 0.4 2.2 5.5 2.3 0.1 0.3 2.3 -0.4
Number of full sisters 1.0 1.2 5.5 0.2 2.4 -0.0 0.4 0.6
Suffer from ‘nerves’ 0.5 0.8 1.6 -0.3 -1.2 -0.2 -1.3 1.0
Overall health rating 0.8 1.8 3.5 -1.0 1.4 0.5 -1.9 1.5
Chest pain or discomfort 0.9 1.3 4.3 -0.5 0.1 0.8 -1.1 2.1
Had major operations 1.1 1.2 3.3 -0.8 -1.8 1.4 -0.1 -0.6
Age at last live birth 0.6 0.8 2.1 -0.7 -1.2 1.4 -0.1 0.2
Family relationship satisfaction 1.1 1.4 4.0 0.3 1.1 1.1 -0.7 2.0
Leg pain on walking 0.7 0.8 3.5 -0.0 -0.4 -1.9 0.2 -0.6
Qualifications: NVQ or HND or HNC or equivalent 2.3 2.8 6.8 1.4 1.1 -0.3 2.0 -2.6
Commuting to job workplace: Car/motor vehicle 0.4 0.5 1.3 -0.6 -1.1 -0.5 -0.4 -0.7
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 0.9 -1.0 -0.7 0.4 -0.1 -0.9
Medication: Aspirin 0.4 0.6 2.1 0.0 -0.0 0.8 -0.2 1.5
Supplements: Vitamin C 0.6 0.7 1.4 -0.4 -0.9 -1.2 1.0 -0.5
Knee pain experienced in last month 1.4 2.2 5.3 1.5 1.3 -1.2 0.5 2.3
Hypertension (Self-reported) 1.7 4.7 11.2 -1.4 -0.1 0.9 -3.3 3.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 1.4 -0.0 1.2 0.4 -0.2 -0.3
Illnesses of father: Heart disease 0.2 0.3 0.9 -0.6 0.1 0.5 -0.1 -1.0
Illnesses of siblings: Diabetes 1.3 1.6 3.1 -1.4 -0.6 1.2 -1.7 -1.0
Smoking status: Previous 0.1 0.1 0.2 -0.1 -0.5 -0.4 -0.2 0.4
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.7 5.6 0.5 -1.2 0.1 2.4 -1.2
Whole body fat-free mass 0.1 0.8 2.3 0.2 -0.8 -1.5 0.9 0.0
Leg fat-free mass (right) 0.5 2.5 5.2 -1.3 -2.3 -1.1 1.5 -1.5
Arm fat percentage (left) 1.6 6.4 15.7 -4.0 -2.3 -0.6 0.5 -3.3
Average weekly red wine intake 0.7 1.1 2.2 -0.4 -1.2 -1.5 1.1 -0.6
Handedness (chirality/laterality): Left-handed 0.7 0.8 1.7 -1.1 0.7 -0.6 -0.6 1.3
Mood swings 0.5 0.9 2.1 1.1 0.3 -1.4 0.7 -0.9
Loneliness, isolation 0.1 0.1 0.2 0.1 0.4 -0.2 0.4 0.4
Long-standing illness, disability or infirmity 1.5 2.3 6.6 0.5 1.1 0.5 -1.8 2.6
Ever had bowel cancer screening 0.5 0.6 1.5 0.4 0.4 -0.2 -1.2 1.1
Diabetes diagnosed by doctor 0.3 0.4 1.1 1.0 0.5 -0.0 -0.9 0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 1.2 -0.5 -1.1 0.3 -0.1 0.7
Friendships satisfaction 1.0 1.2 2.4 -1.2 0.5 1.1 -0.9 1.5
Qualifications: nursing, teaching 0.6 0.9 1.5 -1.2 -0.7 0.8 -1.2 0.8
Commuting to job workplace: Walk 0.3 0.4 1.4 0.3 0.3 0.1 1.2 -0.4
Eye problems/disorders: Cataract 0.4 0.5 1.1 1.0 0.1 0.8 0.6 0.5
Mouth/teeth dental problems: Mouth ulcers 0.0 0.1 0.1 0.1 0.3 -0.2 -0.4 -0.3
Medication for cholesterol 0.4 0.7 2.6 -1.6 -0.6 0.4 -0.2 -0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.0 3.5 0.3 1.9 -0.4 -0.8 0.8
Back pain experienced in last month 1.8 2.6 7.5 0.2 2.7 0.7 -0.4 2.2
Mineral and other dietary supplements 0.4 0.5 1.5 -1.2 -0.4 -0.5 -0.6 0.4
Breast cancer (self-reported) 1.1 1.4 2.7 1.4 -0.7 -1.6 1.0 -0.8
Asthma (self-reported) 1.9 3.8 10.4 -1.5 0.1 -0.0 -3.2 2.6
Osteoporosis (self-reported) 1.8 2.3 4.9 -1.6 0.9 1.0 -2.2 1.5
Osteoarthritis (self-reported) 0.3 0.3 1.0 -0.3 0.3 -0.4 -0.5 -1.0
Medication: Aspirin 0.5 0.7 2.1 -0.0 0.4 1.0 -0.2 1.5
Medication: Gliclazide 1.2 1.4 3.6 -1.3 -0.6 0.7 -1.9 0.8
Illnesses of father: None of the above (group 1) 0.8 1.0 2.6 1.6 1.4 0.0 0.6 0.5
Smoking status: Current 0.3 0.5 1.5 -0.4 1.2 -0.4 -0.6 0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.4 2.9 6.4 2.5 -0.1 -1.8 1.1 -1.9
Whole body water mass 0.1 0.8 2.6 0.3 -0.7 -1.6 1.0 -0.0
Leg predicted mass (right) 0.5 2.5 5.3 -1.3 -2.3 -1.0 1.4 -1.5
Arm fat mass (left) 0.9 3.5 9.5 -3.1 -1.8 -1.0 0.2 -2.0
Number of self-reported non-cancer illnesses 1.9 3.3 8.5 0.4 1.6 0.2 -2.3 2.9
Average weekly champagne plus white wine intake 1.1 1.6 4.9 0.4 2.2 1.6 -0.1 -0.3
Miserableness 0.2 0.4 0.8 -0.7 -0.1 -0.2 -0.8 0.9
Guilty feelings 0.4 0.6 1.6 -0.7 0.3 -0.6 0.8 -1.2
Wears glasses or contact lenses 0.6 0.7 1.4 0.7 -0.9 -0.6 -1.2 0.5
Ever taken oral contraceptive pill 0.8 0.9 1.5 1.0 1.2 -1.1 -0.0 1.0
Hearing aid user 0.8 0.9 2.5 -0.4 -1.6 1.0 -0.4 -0.8
Mother’s age at death 0.6 0.8 2.0 -1.4 0.1 0.7 -0.1 -1.2
Financial situation satisfaction 0.7 0.8 1.5 -1.2 -1.0 0.7 -0.7 0.9
Tinnitus: Yes, now most or all of the time 0.3 0.3 1.0 0.1 -0.4 -1.0 0.2 -0.7
Commuting to job workplace: Public transport 0.4 0.5 1.0 -0.8 0.7 1.0 -0.3 0.4
Eye problems/disorders: Glaucoma 2.0 2.3 5.7 -2.4 -1.2 0.8 -1.6 1.1
Medication: Blood pressure 1.5 2.8 6.8 0.2 0.3 1.0 -2.5 2.6
Pain type(s) experienced in last month: Hip pain 0.7 0.9 2.1 1.1 1.0 -1.4 0.3 0.3
Supplements: Fish oil (including cod liver oil) 0.4 0.6 2.0 0.6 0.6 1.4 -0.3 0.3
High cholesterol (Self-reported) 1.1 1.9 5.3 1.4 2.3 0.1 0.1 1.6
Medication: Bendroflumethiazide 2.2 3.4 8.1 -1.7 -0.9 1.5 -2.9 1.8
Medication: Paracetamol 0.3 0.4 0.7 -0.3 0.9 -0.8 -0.7 0.2
Medication: Lisinopril 0.1 0.1 0.3 -0.5 -0.1 0.3 -0.5 -0.0
Medication: Atorvastatin 0.9 1.1 3.6 0.4 0.5 0.4 -1.2 1.9
Illnesses of father: High blood pressure 0.9 1.1 1.6 -1.0 -1.2 -0.3 -1.2 -1.3
Alcohol drinker status: Never 0.6 0.7 1.3 1.2 1.0 -0.5 0.8 0.6
Ever smoked 0.1 0.1 0.2 -0.4 -0.5 -0.4 -0.1 0.1
Basal metabolic rate 0.2 0.9 2.1 -0.5 -1.1 -1.5 0.9 -0.5
Leg fat percentage (left) 0.9 3.4 12.0 -3.5 -0.3 -1.1 -1.4 -1.4
Arm fat-free mass (left) 0.1 0.7 3.0 -0.1 -0.3 -1.7 0.1 0.5
Number of operations (self-reported) 0.7 1.0 3.8 -0.9 -0.2 0.7 -1.9 0.2
Average weekly beer plus cider intake 3.2 4.6 10.5 3.2 1.7 -1.5 2.6 -0.5
Irritability 0.3 0.6 2.0 -0.1 -0.2 -1.4 -0.1 0.9
Risk taking 1.2 1.8 7.6 -0.0 -1.0 -2.8 0.3 0.2
Ever had prostate specific antigen (PSA) test 0.9 1.0 2.5 -0.1 0.9 -0.0 -1.3 1.6
Fractured/broken bones in last 5 years 2.1 2.7 7.8 -1.7 -0.6 0.8 -2.8 1.3
Age started oral contraceptive pill 0.5 0.7 1.3 -0.9 -0.8 0.8 -1.1 0.4
Diastolic blood pressure, automated reading 2.1 6.4 17.0 -3.2 -1.4 -0.1 -4.1 1.7
Ever depressed for a whole week 1.0 1.2 2.7 0.4 0.9 -1.1 -1.1 1.6
Unable to work because of sickness or disability 0.4 0.5 0.8 0.8 0.8 -0.0 0.9 -0.6
Commuting to job workplace: Cycle 0.9 1.0 2.9 1.7 0.1 -0.4 1.4 0.3
Myopia 0.6 0.8 2.7 -0.1 -0.6 -0.0 -1.0 1.7
Vascular/heart problems diagnosed by doctor 2.0 5.3 12.3 1.5 0.3 -0.8 3.4 -3.5
Cholesterol lowering medication 2.5 3.7 10.2 3.2 2.5 -0.4 1.1 0.9
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 1.2 1.1 0.7 -0.5 0.1 0.2
Pain experienced in last month 1.4 2.3 4.4 -1.4 -1.6 1.4 -0.7 -2.1
Supplements: Calcium 0.3 0.3 0.7 -0.0 -0.5 0.4 0.5 0.8
Basal cell carcinoma (self-reported) 3.2 3.8 6.6 2.6 -0.3 -2.1 2.5 -1.3
Heart attack/myocardial infarction (self-reported) 0.7 0.9 1.8 1.4 0.1 -0.8 1.3 0.4
Deep venous thrombosis (DVT) (self-reported) 1.0 1.2 4.3 2.1 1.0 -0.7 0.2 -0.7
Heart disease (siblings) 0.6 0.8 1.8 1.3 -0.4 -0.7 1.0 -0.7
Alcohol drinker status: Previous 1.0 1.2 2.6 -1.6 -1.5 0.7 -0.2 -0.6
Pack years of smoking 4.0 5.8 17.7 -1.2 0.8 0.1 -4.2 3.1
Impedance of whole body 0.4 2.2 4.0 -1.7 0.0 2.0 0.7 -1.9
Leg fat mass (left) 0.7 2.9 9.1 -3.0 -0.8 -1.4 -0.3 -1.7
Arm predicted mass (left) 0.2 0.8 3.1 0.1 -0.2 -1.8 -0.0 0.9