[Hub]/) : Traits : Heel T-Score :

chr5:53,702,093-56,923,759

Best TWAS P=1.28e-22 · Best GWAS P=4.62e-25 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Artery Aorta SKIV2L2 0.11 0.04 enet 17 0.08 3.4e-05 -10.0 7.0 2.9e-12 -0.76 0.07 0.92 FALSE
2 GTEx Artery Aorta DHX29 0.06 0.05 lasso 3 0.02 1.8e-02 -10.0 9.8 1.3e-22 -0.97 0.08 0.78 TRUE
3 GTEx Artery Tibial SKIV2L2 0.16 0.08 lasso 5 0.08 1.2e-06 7.4 8.9 5.4e-19 -0.41 0.83 0.15 TRUE
4 GTEx Breast Mammary Tissue GPX8 0.06 0.00 lasso 4 0.01 1.6e-01 -8.0 6.5 8.9e-11 -0.87 0.12 0.47 TRUE
5 GTEx Breast Mammary Tissue CTD-2310F14.1 0.14 -0.01 enet 23 0.01 6.7e-02 2.5 -5.3 1.3e-07 0.03 0.02 0.04 TRUE
6 GTEx Cells Transformed fibroblasts SKIV2L2 0.08 0.07 enet 21 0.07 8.0e-06 7.4 8.4 3.5e-17 -0.47 0.62 0.18 FALSE
7 GTEx Testis GZMA 0.10 0.04 lasso 7 0.03 1.4e-02 -7.2 -6.4 1.4e-10 0.69 0.26 0.31 FALSE
8 GTEx Testis SLC38A9 0.11 0.00 enet 39 -0.01 6.4e-01 -8.3 -5.2 1.8e-07 0.55 0.06 0.30 FALSE
9 ROSMAP Brain Pre-frontal Cortex CCNO 0.13 0.14 lasso 10 0.14 1.8e-17 -7.3 7.6 2.8e-14 -0.75 0.92 0.08 FALSE
10 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma CCNO 0.06 0.03 blup 45 0.03 1.6e-02 -6.6 7.2 6.0e-13 -0.74 0.03 0.80 FALSE
11 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PPAP2A 0.14 0.00 blup 58 0.03 4.4e-04 1.1 5.7 1.1e-08 -0.40 0.02 0.06 FALSE
12 The Cancer Genome Atlas Brain Lower Grade Glioma CCNO 0.03 0.02 blup 45 0.03 4.9e-04 7.2 8.3 8.4e-17 -0.43 0.22 0.07 FALSE
13 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma DHX29 0.04 0.03 lasso 2 0.02 2.3e-02 -6.9 -7.6 3.2e-14 0.89 0.02 0.91 FALSE
14 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma SKIV2L2 0.06 0.04 blup 73 0.03 2.8e-03 -8.4 -9.1 1.2e-19 0.90 0.04 0.90 FALSE
15 The Cancer Genome Atlas Prostate Adenocarcinoma CCNO 0.09 0.06 blup 45 0.07 1.5e-07 -7.2 6.8 8.1e-12 -0.76 0.01 0.99 FALSE
16 The Cancer Genome Atlas Prostate Adenocarcinoma DHX29 0.04 0.04 blup 54 0.06 1.8e-06 -7.2 8.8 8.5e-19 -0.87 0.07 0.93 TRUE
17 The Cancer Genome Atlas Testicular Germ Cell Tumors CDC20B 0.17 0.00 blup 65 0.02 7.9e-02 -6.6 5.2 2.0e-07 -0.51 0.01 0.62 FALSE
18 The Cancer Genome Atlas Thyroid Carcinoma CDC20B 0.04 0.02 lasso 2 0.03 1.2e-03 5.1 -7.0 2.4e-12 0.37 0.03 0.51 FALSE