Best TWAS P=1.28e-22 · Best GWAS P=4.62e-25 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | SKIV2L2 | 0.11 | 0.04 | enet | 17 | 0.08 | 3.4e-05 | -10.0 | 7.0 | 2.9e-12 | -0.76 | 0.07 | 0.92 | FALSE |
| 2 | GTEx | Artery Aorta | DHX29 | 0.06 | 0.05 | lasso | 3 | 0.02 | 1.8e-02 | -10.0 | 9.8 | 1.3e-22 | -0.97 | 0.08 | 0.78 | TRUE |
| 3 | GTEx | Artery Tibial | SKIV2L2 | 0.16 | 0.08 | lasso | 5 | 0.08 | 1.2e-06 | 7.4 | 8.9 | 5.4e-19 | -0.41 | 0.83 | 0.15 | TRUE |
| 4 | GTEx | Breast Mammary Tissue | GPX8 | 0.06 | 0.00 | lasso | 4 | 0.01 | 1.6e-01 | -8.0 | 6.5 | 8.9e-11 | -0.87 | 0.12 | 0.47 | TRUE |
| 5 | GTEx | Breast Mammary Tissue | CTD-2310F14.1 | 0.14 | -0.01 | enet | 23 | 0.01 | 6.7e-02 | 2.5 | -5.3 | 1.3e-07 | 0.03 | 0.02 | 0.04 | TRUE |
| 6 | GTEx | Cells Transformed fibroblasts | SKIV2L2 | 0.08 | 0.07 | enet | 21 | 0.07 | 8.0e-06 | 7.4 | 8.4 | 3.5e-17 | -0.47 | 0.62 | 0.18 | FALSE |
| 7 | GTEx | Testis | GZMA | 0.10 | 0.04 | lasso | 7 | 0.03 | 1.4e-02 | -7.2 | -6.4 | 1.4e-10 | 0.69 | 0.26 | 0.31 | FALSE |
| 8 | GTEx | Testis | SLC38A9 | 0.11 | 0.00 | enet | 39 | -0.01 | 6.4e-01 | -8.3 | -5.2 | 1.8e-07 | 0.55 | 0.06 | 0.30 | FALSE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | CCNO | 0.13 | 0.14 | lasso | 10 | 0.14 | 1.8e-17 | -7.3 | 7.6 | 2.8e-14 | -0.75 | 0.92 | 0.08 | FALSE |
| 10 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | CCNO | 0.06 | 0.03 | blup | 45 | 0.03 | 1.6e-02 | -6.6 | 7.2 | 6.0e-13 | -0.74 | 0.03 | 0.80 | FALSE |
| 11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PPAP2A | 0.14 | 0.00 | blup | 58 | 0.03 | 4.4e-04 | 1.1 | 5.7 | 1.1e-08 | -0.40 | 0.02 | 0.06 | FALSE |
| 12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CCNO | 0.03 | 0.02 | blup | 45 | 0.03 | 4.9e-04 | 7.2 | 8.3 | 8.4e-17 | -0.43 | 0.22 | 0.07 | FALSE |
| 13 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | DHX29 | 0.04 | 0.03 | lasso | 2 | 0.02 | 2.3e-02 | -6.9 | -7.6 | 3.2e-14 | 0.89 | 0.02 | 0.91 | FALSE |
| 14 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | SKIV2L2 | 0.06 | 0.04 | blup | 73 | 0.03 | 2.8e-03 | -8.4 | -9.1 | 1.2e-19 | 0.90 | 0.04 | 0.90 | FALSE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CCNO | 0.09 | 0.06 | blup | 45 | 0.07 | 1.5e-07 | -7.2 | 6.8 | 8.1e-12 | -0.76 | 0.01 | 0.99 | FALSE |
| 16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | DHX29 | 0.04 | 0.04 | blup | 54 | 0.06 | 1.8e-06 | -7.2 | 8.8 | 8.5e-19 | -0.87 | 0.07 | 0.93 | TRUE |
| 17 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | CDC20B | 0.17 | 0.00 | blup | 65 | 0.02 | 7.9e-02 | -6.6 | 5.2 | 2.0e-07 | -0.51 | 0.01 | 0.62 | FALSE |
| 18 | The Cancer Genome Atlas | Thyroid Carcinoma | CDC20B | 0.04 | 0.02 | lasso | 2 | 0.03 | 1.2e-03 | 5.1 | -7.0 | 2.4e-12 | 0.37 | 0.03 | 0.51 | FALSE |