Hub : Genes

SKIV2L2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.114	0.0430	2.4e-05	0.043	NA	0.080	NA	0.040	2.1e-03	NA	3.4e-05	NA	2.8e-03
2	GTEx	Artery Tibial	0.159	0.0472	1.1e-06	0.082	NA	0.059	NA	0.077	5.2e-07	NA	2.2e-05	NA	1.1e-06
3	GTEx	Cells Transformed fibroblasts	0.084	0.0390	1.5e-03	0.067	NA	0.068	NA	0.062	9.5e-06	NA	8.0e-06	NA	1.9e-05
4	GTEx	Testis	0.243	0.0700	1.2e-05	0.142	NA	0.106	NA	0.116	7.2e-07	NA	1.9e-05	NA	8.1e-06
5	GTEx	Whole Blood	0.102	0.0450	5.1e-03	0.028	NA	0.029	NA	0.035	1.1e-03	NA	9.7e-04	NA	3.6e-04
6	TCGA	Ovarian Serous Cystadenocarcinoma	0.064	0.0390	3.5e-04	0.043	0.032	0.028	NA	0.022	7.2e-04	0.0028	5.4e-03	NA	1.1e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.6	0.9	1.9	-0.4	-1.4	-1.1	-1.0	-0.7	0.8
Bipolar Disorder or Schizophrenia	0.1	0.2	0.6	-0.8	-0.1	0.0	0.2	-0.7	0.5
Depressed Affect (Nagel 2018)	0.3	0.5	1.9	1.4	-0.6	0.1	-0.8	0.5	-0.3
Depression (Nagel 2018)	0.7	1.0	4.6	0.7	0.8	0.3	-0.0	2.1	-0.3
Intelligence (Savage-Jansen 2018)	0.2	0.6	2.5	-1.6	-0.6	-0.1	0.5	0.2	0.8
Neuroticism (Nagel 2018)	0.1	0.2	0.4	-0.0	-0.3	0.4	-0.5	0.6	-0.1
Schizophrenia (2018)	0.2	0.5	1.2	-0.7	1.0	0.6	1.1	-0.1	-0.0
Schizophrenia vs Biploar Disorder	0.2	0.3	0.8	0.2	0.9	-0.1	0.3	-0.6	-0.5
Worry (Nagel 2018)	0.3	0.7	1.8	-1.3	-0.7	-0.2	-0.6	1.1	0.4
Alzheimer’s Disease (in mother)	3.9	4.6	8.2	-2.4	-2.9	-2.7	-0.7	-0.1	2.4
Alzheimer’s Disease (in father)	4.1	4.5	10.4	-1.1	-2.7	-3.2	-1.6	1.7	1.5
Alzheimer’s Disease (including proxy)	4.0	5.8	10.7	-2.4	-3.0	-3.3	-0.5	1.2	2.8
Crohns Disease (2017)	0.7	1.6	2.5	-0.6	-1.6	-1.4	-0.7	1.4	1.6
Irritable Bowel Disease (IBD)	1.3	3.1	5.9	-1.5	-2.4	-2.0	-0.9	0.4	2.3
Ulcerative Colitis (UC)	1.1	2.1	3.9	-1.6	-1.9	-1.5	-0.3	-0.1	2.0
Major Depression (MDD)	0.9	1.1	2.7	-1.1	0.0	-0.7	1.0	1.7	1.1
Reaction Time	0.4	0.8	1.6	1.1	0.9	1.0	-0.4	0.3	-1.2
Verbal and Numeric Reasoning (VNR)	0.1	0.1	0.5	-0.7	-0.2	-0.0	0.0	0.5	0.1
Breast Cancer	0.4	0.9	2.3	1.5	-0.2	0.9	-0.7	0.5	-1.1
Ovarian Cancer	0.8	1.1	3.4	-0.3	-1.2	-0.8	-0.9	-1.8	0.4
Prostate Cancer	0.6	0.8	1.6	-0.1	1.3	0.9	1.2	0.8	-0.6
Age at First Birth	1.0	1.4	4.5	-1.0	1.1	-0.6	2.1	0.0	1.2
Bipolar Disorder (2011)	0.7	0.7	1.7	-0.7	-0.4	-1.3	-0.3	-1.0	0.8
Body Mass Index (BMI) (2010)	0.7	0.9	2.1	-1.0	0.0	-0.6	1.4	-1.0	1.0
Coronary Artery Disease (CAD)	0.4	0.5	1.2	1.1	0.7	-0.6	0.2	-0.9	-0.4
Crohns Disease (2012)	1.0	1.7	3.2	0.1	-1.6	-1.8	-0.8	1.1	1.5
Mean Putamen Volume	3.0	3.4	6.7	-2.0	-1.5	-2.6	0.3	-1.6	2.2
Fasting Glucose	0.4	0.5	1.4	0.3	0.6	-0.4	-0.7	-1.2	-0.6
HbA1C	1.3	1.4	4.2	-2.1	0.1	0.9	1.5	0.3	1.1
HDL Cholesterol	0.2	0.3	1.4	0.5	-0.0	-1.2	-0.2	-0.4	-0.2
LDL Cholesterol	0.3	0.4	1.4	0.3	-0.2	0.1	0.7	-1.2	0.7
Lupus	1.2	1.8	4.5	0.3	1.2	1.7	2.1	-1.4	0.4
Neuroticism (2016)	1.1	1.6	3.9	-1.0	-1.1	-1.1	0.8	1.4	2.0
Primary Biliary Cirrhosis	0.2	0.3	0.6	0.8	0.6	0.8	0.4	0.2	-0.4
Rheumatoid Arthritis	0.7	1.0	3.2	1.3	0.8	-0.2	0.5	-1.8	-0.5
Schizophrenia (2014)	0.1	0.3	1.1	-1.0	0.1	0.0	0.6	-0.4	0.5
Triglycerides	0.5	0.9	2.0	-1.3	-0.2	-0.0	1.2	-0.3	1.4
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.7	-0.7	1.6	0.8	1.3	0.2	-0.1
Ulcerative Colitis	1.1	1.6	4.2	-0.5	-1.7	-2.1	-1.1	-0.3	0.9
Blood Eosinophil Count	0.7	5.7	11.2	3.4	1.5	2.0	-2.4	-0.2	-3.3
Blood Platelet Count	0.2	2.8	8.8	-3.0	-0.1	0.9	1.9	-0.9	1.7
Blood Red Count	0.2	1.5	4.0	-1.4	0.4	-1.1	2.0	0.3	1.3
Blood White Count	0.5	3.7	11.6	-3.4	-0.6	-1.7	1.6	0.5	2.1
Heel T-Score	6.0	47.4	82.3	7.0	8.9	8.4	1.6	0.5	-9.1
BMI	0.3	2.0	11.2	0.4	0.4	0.1	0.5	-3.4	-0.1
Height	1.5	28.8	58.2	-7.0	3.2	0.1	7.6	5.5	5.0
Waist Hip Ratio (WHR)	2.0	9.1	22.8	-3.9	-1.5	-2.0	3.1	0.2	4.8
Systolic Blood Pressure	0.1	0.5	1.5	-1.2	-0.2	0.6	0.2	-0.0	0.9
Smoking Status	0.1	0.3	0.6	-0.4	0.5	0.0	-0.7	0.5	-0.8
Allergy or Eczema	0.6	1.6	3.1	1.8	1.3	1.3	0.6	-1.2	-1.1
Cardiovascular Disease	0.1	0.2	0.9	-0.5	-0.5	0.2	-0.0	0.9	0.1
Hypothyroidism (self reported)	1.9	4.4	10.1	-0.2	-3.2	-3.1	-1.9	-0.3	1.8
Respiratory disease	0.8	1.7	4.5	-1.8	0.8	-0.6	2.1	-0.4	1.1
Type 2 Diabetes (T2D) (2018)	0.5	1.0	2.6	-0.8	0.2	0.1	1.6	-0.8	1.4
Lung FEV1/FVC ratio	0.6	3.1	7.2	2.4	-0.5	0.8	-2.7	1.0	-2.0
Lung FVC	1.1	5.7	11.3	2.9	1.8	3.4	-1.1	0.8	-3.1
Neuroticism	0.4	0.9	2.2	-0.9	-1.5	-0.6	-0.6	-0.5	1.2
Chronotype (morning person)	0.6	1.3	2.5	1.2	-1.2	-1.5	-1.6	0.3	-0.4
Hair Pigment	0.0	0.6	2.2	-0.4	0.5	0.0	0.9	-1.5	0.3
Tanning	0.0	0.2	0.9	0.4	-0.2	0.3	-0.1	-1.0	0.1
Hand grip strength (left)	0.3	0.9	2.7	-0.6	1.4	0.6	1.7	-0.1	-0.3
Number of treatments/medications taken	0.5	1.0	1.9	-0.8	0.0	-1.0	1.4	-0.9	1.3
Average weekly spirits intake	0.5	0.6	1.5	-0.6	-0.7	-1.0	0.4	-0.1	1.2
Sensitivity / hurt feelings	0.7	1.2	4.5	0.1	-1.2	-0.5	-2.1	-0.7	-0.7
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.6	0.8	-0.2	-0.5	-0.2	0.5	0.5
Hearing difficulty/problems: Yes	0.7	1.1	1.9	1.3	0.4	1.4	-0.6	0.6	-1.4
Relative age of first facial hair	0.8	1.7	3.6	-1.9	-1.2	-1.6	0.2	0.2	1.7
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	3.5	-0.2	-1.9	-1.6	-1.7	-0.7	0.4
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.1	-0.5	0.2	0.2	1.1	-0.5	0.6
Ever had hysterectomy (womb removed)	1.8	2.0	4.6	-1.1	-2.1	-1.1	0.0	-0.8	2.1
Systolic blood pressure, automated reading	0.7	2.0	3.8	-1.9	-1.9	-1.3	-1.0	0.4	1.3
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.9	-0.0	0.9	0.9	0.8	0.2	-0.0
Angina	0.3	0.5	1.2	0.0	0.5	-0.7	-0.4	0.8	-1.1
Medication for hormone replacement therapy	1.0	1.1	3.3	-0.1	-1.1	-1.3	-0.7	1.8	0.4
Vitamin and mineral supplements	1.4	1.9	4.4	2.1	1.0	0.8	-1.0	0.5	-2.0
Supplements: Zinc	2.1	2.2	6.6	-2.6	-1.1	-1.9	-0.5	0.4	1.3
Medication: Co-codamol	2.2	2.6	7.5	-0.1	-0.7	-1.2	-2.7	1.7	-1.7
Medication: Metformin	0.2	0.3	1.0	-0.0	-0.3	-0.0	0.8	-0.2	1.0
Diabetes (father)	1.4	1.8	4.2	-2.1	-1.4	-1.3	-0.2	-0.2	1.6
Diabetes (mother)	1.5	2.0	3.1	1.7	1.7	1.5	0.4	0.7	-1.8
Severe depression (siblings)	0.5	0.6	1.9	-1.4	-0.1	-0.3	1.0	0.0	0.8
Pack years adult smoking proportion	1.3	2.1	5.2	-0.4	-2.3	-2.1	-1.3	0.2	0.9
Impedance of leg (right)	0.3	1.2	3.9	0.8	-1.5	-0.7	-2.0	0.5	0.1
Leg fat-free mass (left)	1.0	5.4	16.2	-3.0	1.6	-0.4	4.0	0.1	2.1
Trunk fat percentage	0.4	1.6	7.5	1.4	0.0	0.0	0.1	-2.7	-0.5
Hand grip strength (right)	0.4	1.1	1.8	-1.2	1.3	1.1	1.3	0.7	-0.6
Townsend deprivation index at recruitment	1.0	1.4	2.4	1.1	-1.4	-1.5	-1.5	-0.8	-0.1
Current tobacco smoking	0.7	1.1	3.3	-1.8	-0.6	-1.7	-0.0	0.2	0.6
Average weekly fortified wine intake	0.6	0.7	2.3	-0.5	0.6	0.5	1.5	-0.7	0.6
Maternal smoking around birth	0.1	0.1	0.2	0.2	0.5	0.1	0.1	-0.4	-0.3
Fed-up feelings	0.1	0.2	0.6	-0.0	-0.7	-0.8	-0.4	0.1	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	4.9	0.1	0.7	0.1	0.5	2.2	0.2
Relative age voice broke	0.5	0.7	1.6	0.5	0.8	0.9	0.2	1.3	-1.0
Taking other prescription medications	0.5	0.7	2.1	0.6	0.4	-0.8	0.9	-1.5	0.2
Age when periods started (menarche)	0.1	0.3	0.7	-0.7	0.1	0.5	0.7	-0.2	0.8
Bilateral oophorectomy (both ovaries removed)	1.5	1.7	4.8	-1.0	-0.7	-1.1	1.6	-0.1	2.2
Heel bone mineral density (BMD) T-score, automated (left)	6.1	13.9	28.9	2.8	5.4	5.0	2.9	-0.8	-3.5
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.9	0.2	-0.6	-0.2	-1.4	1.0	-0.4
Qualifications: CSEs or equivalent	1.1	1.4	5.1	0.9	-0.9	-0.6	-1.2	2.3	-0.1
Serious illness, injury or assault to yourself	1.0	1.2	2.4	-1.6	-0.9	-1.5	-0.8	1.0	0.3
High blood pressure	0.2	0.6	1.2	0.7	0.0	1.1	-0.7	-0.8	-1.1
Hayfever, allergic rhinitis or eczema	0.7	1.4	2.3	1.5	0.9	1.1	-0.5	-1.3	-1.5
Multivitamins +/- minerals	2.2	2.7	7.7	-2.8	-0.9	-1.2	1.3	-0.3	2.2
Stomach or abdominal pain in last month	0.2	0.2	0.8	-0.1	-0.5	-0.9	-0.5	-0.2	0.1
Supplements: Glucosamine	0.6	0.8	2.6	-1.6	-0.5	-0.3	-0.6	-1.0	0.4
Diverticular disease/diverticulitis (self-reported)	2.2	2.6	6.5	-0.3	-2.3	-2.5	-1.3	-0.9	1.2
Medication: Atenolol	1.0	1.3	2.8	-0.7	-1.7	-1.4	-1.6	0.1	0.3
Medication: Levothyroxine sodium	0.9	1.5	3.5	-0.6	-1.7	-1.9	-0.4	-0.4	1.4
Sitting height	1.9	13.4	29.2	-5.4	1.4	-1.3	5.0	2.6	4.0
Chronic bronchitis/emphysema (father)	0.4	0.4	1.4	0.3	0.9	0.4	-0.0	-0.0	-1.2
High blood pressure (mother)	1.4	1.9	6.3	1.1	0.6	0.3	-0.9	2.5	-1.7
Body mass index (BMI)	0.5	2.0	9.2	1.2	0.5	0.1	0.7	-3.0	-0.6
Impedance of leg (left)	0.2	1.2	3.8	0.5	-1.6	-0.6	-1.9	0.3	0.1
Leg predicted mass (left)	1.0	5.2	15.7	-2.9	1.5	-0.4	4.0	0.1	2.2
Trunk fat mass	0.3	1.3	5.6	0.1	0.4	-0.1	1.4	-2.4	0.4
Waist circumference	0.2	0.9	2.4	-0.3	0.1	-0.3	1.5	-1.5	0.9
Number of incorrect matches in round	0.4	0.7	2.2	0.2	-1.3	0.1	-1.5	0.5	0.1
Past tobacco smoking	0.3	0.5	1.2	-0.1	-0.3	-0.8	1.0	0.7	1.1
Alcohol usually taken with meals	0.2	0.4	0.9	-0.9	-0.6	-0.7	-0.2	-0.4	0.4
Nervous feelings	0.4	0.7	1.6	-1.3	-0.6	-0.4	-0.8	1.2	0.2
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	3.9	-0.7	0.6	-0.7	2.0	1.9	1.1
Hearing difficulty/problems with background noise	1.0	1.7	3.7	1.9	1.4	1.3	-0.2	-0.2	-1.6
Hair/balding pattern: Pattern 2	2.7	3.5	7.5	1.7	2.7	1.7	2.2	-1.5	-0.5
Had menopause	2.5	3.1	7.1	-2.1	-1.3	-1.8	0.2	-2.7	1.6
Had other major operations	2.1	2.6	8.9	-0.3	-1.8	-3.0	-0.9	-0.3	1.5
Forced vital capacity (FVC)	1.2	4.5	8.7	-0.8	2.5	2.2	3.0	2.7	0.2
Heel bone mineral density (BMD) T-score, automated (right)	6.0	13.7	26.6	3.2	5.2	5.0	2.4	-0.5	-3.8
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.8	0.1	-0.2	-0.0	0.7	0.9	0.5
Qualifications: None of the above	1.1	2.5	6.3	2.5	0.1	1.3	-1.3	-1.4	-1.8
Financial difficulties in last 2 years	2.1	2.9	6.2	-0.5	-2.1	-2.3	-2.5	0.9	0.1
Mouth/teeth dental problems	0.6	1.0	3.3	0.9	1.0	0.4	1.8	-0.6	0.2
Heart attack	0.6	0.7	1.9	1.2	-0.6	-0.1	-1.4	0.6	-0.6
Allergy	0.6	1.3	2.1	-1.1	-1.4	-1.1	-0.5	1.0	1.4
Pain all over the body in last month	1.4	1.5	3.8	1.7	1.1	0.5	-0.9	0.3	-2.0
Diabetes (self-reported)	0.3	0.5	1.6	-0.3	-0.2	-0.3	1.1	-0.3	1.3
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	2.0	0.1	-0.9	-0.2	-1.4	-0.4	-0.4
Medication: Ramipril	0.0	0.1	0.2	-0.4	0.2	-0.1	0.0	0.3	0.1
Medication: Simvastatin	0.5	0.7	1.7	-0.2	-1.3	-0.7	-0.1	1.1	0.7
Fluid intelligence score	0.1	0.2	0.8	-0.5	0.2	0.4	0.4	-0.9	-0.0
Illnesses of siblings	0.8	1.1	2.5	-0.6	-1.6	-1.4	-0.5	-0.8	0.9
Neuroticism score	0.2	0.4	0.9	-0.3	-0.9	-0.7	-0.9	-0.3	0.4
Weight	0.6	2.8	9.3	-1.4	1.1	-0.2	3.0	-1.5	1.4
Impedance of arm (right)	0.2	0.7	2.5	0.9	-0.3	0.4	-1.6	0.5	-0.7
Arm fat percentage (right)	0.7	2.7	11.2	1.9	0.4	0.4	-0.3	-3.4	-1.2
Trunk fat-free mass	1.5	8.7	21.0	-4.6	1.4	-0.8	4.5	0.3	2.9
Hip circumference	0.4	1.9	3.2	1.4	1.8	1.1	1.4	-1.4	-1.0
Time employed in main current job	0.5	0.6	1.7	0.6	0.8	-0.2	-0.5	-1.3	-0.8
Alcohol intake versus 10 years previously	0.3	0.5	0.8	0.9	-0.1	0.9	-0.4	0.4	-0.9
Father’s age at death	1.5	2.0	4.3	0.1	1.6	2.1	2.1	1.0	0.2
Worrier / anxious feelings	0.1	0.2	0.7	-0.3	0.1	0.0	0.8	0.3	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	4.2	-0.8	-0.6	-1.4	0.1	2.1	0.7
Falls in the last year	2.3	3.1	7.4	-2.7	-1.7	-2.3	-0.4	-0.4	1.8
Hair/balding pattern: Pattern 3	0.6	0.8	1.6	0.2	-1.2	-1.3	-1.2	-0.6	0.2
Number of live births	1.4	1.9	5.2	1.4	1.3	0.9	-1.1	0.8	-2.3
Forced expiratory volume in 1-second (FEV1)	1.2	4.2	8.6	0.6	2.3	2.6	1.6	2.9	-1.1
Pulse rate	0.4	0.7	1.4	-1.1	-1.2	-0.5	-0.4	0.1	1.0
Happiness	0.5	0.6	1.5	1.2	0.5	0.7	0.7	1.0	-0.0
Noisy workplace	0.8	1.0	2.9	1.7	-0.1	-0.1	-1.4	-0.0	-1.1
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.8	-1.0	0.8	1.4	1.3	0.1	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.7	-0.8	0.6	-0.4	0.7	-0.4	0.3
Mouth/teeth dental problems: Dentures	0.2	0.4	0.9	-0.2	0.8	0.9	0.8	-0.4	-0.4
Asthma	0.2	0.4	0.9	-0.8	0.9	0.3	0.7	-0.2	-0.4
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.2	5.5	-2.1	-0.8	-0.6	1.5	-0.3	2.3
Medication: Cholesterol lowering	0.2	0.4	0.8	0.5	-0.9	0.3	-0.9	0.5	-0.1
Depression (self-reported)	0.8	1.0	2.4	0.9	-1.0	-0.7	-1.5	1.0	-0.5
Medication: Lansoprazole	2.2	2.6	7.7	-0.2	-1.9	-2.8	-1.4	-1.0	1.1
Prospective memory result	1.2	1.5	4.7	2.2	0.3	-0.2	-1.5	0.4	-1.4
Lung cancer (father)	0.3	0.3	1.3	0.6	0.2	0.2	1.2	-0.4	0.3
Illnesses of mother	0.5	0.7	1.7	1.2	0.5	0.6	0.2	-1.3	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.2	6.9	0.3	1.3	1.8	0.9	2.6	-0.4
Pulse wave Arterial Stiffness index	2.9	3.4	6.7	-2.6	-1.9	-2.2	0.2	-0.4	2.2
Impedance of arm (left)	0.1	0.6	1.0	1.0	0.1	0.9	-0.9	0.8	-0.5
Arm fat mass (right)	0.4	1.6	7.8	0.2	0.7	-0.0	1.2	-2.8	-0.1
Trunk predicted mass	1.5	8.8	21.9	-4.7	1.3	-0.9	4.4	0.2	3.0
Standing height	1.7	17.2	38.4	-6.2	1.5	-1.0	5.6	2.8	4.7
Length of working week for main job	0.7	0.7	1.7	0.6	-0.8	-1.2	-0.7	-1.3	0.2
Exposure to tobacco smoke at home	0.2	0.3	0.5	0.6	0.5	-0.6	0.2	0.7	0.1
Breastfed as a baby	0.1	0.1	0.5	-0.7	-0.3	0.3	-0.2	0.1	0.2
Tense / ‘highly strung’	0.4	0.7	2.6	-0.5	-0.7	-0.8	-1.6	0.6	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.9	0.7	-0.4	-0.9	-0.7	-0.3	0.2
Hair/balding pattern: Pattern 4	0.8	1.8	4.1	-0.9	-2.0	-0.9	-2.0	1.0	0.1
Birth weight of first child	0.9	1.7	4.2	0.9	1.8	0.8	2.0	1.1	-0.3
Peak expiratory flow (PEF)	0.9	2.0	5.4	-1.0	1.4	1.5	2.3	1.1	0.4
Pulse wave reflection index	0.5	0.6	1.5	-0.5	-0.7	-1.1	0.5	0.0	1.2
Ever highly irritable/argumentative for 2 days	1.2	1.4	3.8	-0.3	-1.6	-1.9	-1.1	-0.1	0.8
Loud music exposure frequency	0.9	0.9	2.6	-1.6	-0.9	-0.6	0.3	-0.5	1.3
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.3	-1.5	0.7	0.1	1.2	0.9	0.9
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.3	-0.9	0.0	0.1	-1.0	1.1	-0.3
Blood clot in the leg (DVT)	1.1	1.5	2.9	1.6	1.7	1.0	1.1	-0.0	-1.0
Medication: Paracetamol	0.8	1.3	3.7	0.6	-1.3	-0.5	0.2	-1.9	1.4
Headache pain in last month	0.3	0.6	1.1	-0.7	-0.4	-1.0	0.2	1.1	0.8
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.0	-0.8	0.5	-1.0	0.8	0.4	0.4
Glaucoma (self-reported)	0.6	0.7	2.4	0.5	0.6	0.6	-0.1	1.5	-1.1
Gout (self-reported)	0.8	1.1	2.4	-0.6	0.9	1.4	1.2	-1.6	0.2
Hypothyroidism/myxoedema (self-reported)	2.3	4.5	10.4	-0.7	-3.1	-3.2	-1.2	-0.5	2.2
Medication: Amlodipine	0.8	1.1	3.2	1.3	-0.6	0.1	-1.2	1.8	-0.4
Medication: Ventolin 100micrograms inhaler	1.2	1.5	3.1	-1.2	-0.8	-1.4	1.0	-1.0	1.8
Birth weight	0.6	1.4	3.7	0.1	1.9	1.4	1.4	0.9	-0.4
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.6	-0.7	-0.1	-1.3	-0.2	0.3	0.2
High blood pressure (siblings)	1.0	1.4	2.8	1.0	1.7	1.4	0.8	1.1	-1.0
Forced vital capacity (FVC), Best measure	0.6	2.3	5.2	-1.1	1.2	1.4	1.9	2.3	0.9
Body fat percentage	0.5	1.8	7.5	1.6	-0.1	-0.0	-0.4	-2.7	-0.8
Leg fat percentage (right)	0.5	1.7	6.4	1.4	-0.8	-0.8	-0.7	-2.5	-0.3
Arm fat-free mass (right)	1.3	6.4	15.8	-3.7	1.0	-1.0	4.0	-0.1	2.7
Exposure to tobacco smoke outside home	0.7	0.9	2.9	-0.6	-0.4	-0.9	-1.1	-1.7	-0.1
Comparative body size at age 10	0.8	2.1	5.6	2.4	1.3	1.1	-0.1	-1.3	-1.5
Number of full brothers	0.8	1.0	2.6	0.9	0.0	0.0	-1.6	0.8	-1.4
Worry too long after embarrassment	1.3	2.2	6.2	0.6	1.9	2.5	1.6	-0.4	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.8	1.3	0.0	-1.0	-1.1	0.4	-0.8
Wheeze or whistling in the chest in last year	0.2	0.3	0.5	-0.0	0.7	-0.4	0.7	0.7	-0.4
Number of children fathered	0.2	0.2	0.8	0.3	-0.1	0.4	-0.9	-0.3	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	1.9	2.2	3.5	-1.9	-1.4	-1.8	-0.4	1.6	1.3
Age at first live birth	0.8	1.4	3.5	0.2	1.9	0.7	0.1	1.5	-1.5
Pulse wave peak to peak time	2.4	2.9	4.9	2.2	2.0	2.1	0.1	0.6	-1.9
Health satisfaction	1.2	1.6	4.2	-0.6	-1.6	-2.1	-0.3	0.0	1.5
Shortness of breath walking on level ground	0.8	0.9	3.0	0.2	-1.2	-1.7	-1.1	0.1	-0.0
Qualifications: College or University degree	0.4	1.4	3.7	-0.6	1.9	0.6	1.8	0.8	-0.2
Eye problems/disorders: None of the above	0.4	0.5	1.1	-1.0	0.1	0.2	0.9	0.8	0.6
Mouth/teeth dental problems: Loose teeth	2.5	2.9	8.2	1.1	-0.9	-0.3	-2.9	1.8	-2.0
Emphysema/chronic bronchitis	1.7	1.9	4.4	-2.1	-0.9	-1.1	1.3	-0.3	1.8
Medication for pain relief, constipation, heartburn	0.5	0.8	1.6	-0.2	1.3	1.0	0.6	1.1	-0.7
Neck or shoulder pain in last month	0.4	0.6	1.7	-0.9	0.1	0.1	1.3	-0.4	0.9
Medication: Blood pressure	0.9	1.5	3.5	1.3	-0.2	1.3	-1.9	-0.3	-1.4
Angina (self-reported)	0.5	0.6	1.6	-0.1	0.1	-0.8	-0.9	0.9	-1.2
Migraine (self-reported)	0.4	0.5	1.9	-0.6	0.4	0.8	1.4	-0.4	0.2
Medication: Ibuprofen	1.3	1.6	4.3	-1.5	-1.1	-0.9	0.8	-0.5	2.1
Medication: Allopurinol	0.2	0.3	0.8	-0.9	-0.4	0.6	0.0	-0.6	0.4
Medication: Omeprazole	0.8	0.9	2.3	0.3	-0.0	-1.3	-1.5	-0.1	-1.3
Medication: Seretide 50 evohaler	1.1	1.3	4.8	-2.2	-0.6	-1.0	0.2	0.6	1.1
Mean time to correctly identify matches	0.3	0.6	1.0	1.0	0.4	0.8	-0.6	-0.4	-1.0
Heart disease (mother)	1.3	1.5	4.2	-2.0	-0.5	-1.1	0.8	1.0	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.7	1.6	0.6	1.2	0.5	1.3	0.2	-0.3
Whole body fat mass	0.3	1.3	6.0	-0.2	0.2	-0.3	1.2	-2.4	0.5
Leg fat mass (right)	0.3	1.2	4.5	-0.3	-0.4	-0.9	0.9	-2.1	0.9
Arm predicted mass (right)	1.3	6.5	15.4	-3.9	0.6	-1.5	3.6	0.1	2.8
Pulse rate, automated reading	0.4	1.4	3.6	-1.3	-0.5	-0.6	1.5	-0.5	1.9
Alcohol intake frequency.	0.2	0.4	0.8	0.8	-0.9	-0.2	0.4	-0.3	0.7
Comparative height size at age 10	0.9	5.0	11.0	-3.3	0.3	-1.1	3.0	1.3	2.7
Number of full sisters	1.1	1.3	2.4	1.5	0.9	0.9	-0.6	1.1	-1.5
Suffer from ‘nerves’	1.3	2.0	4.0	-1.1	-2.0	-1.5	-2.0	-0.7	0.6
Overall health rating	1.1	2.3	6.1	-0.9	-1.8	-2.5	-1.1	-0.6	1.3
Chest pain or discomfort	0.5	0.7	3.1	0.0	-0.7	-1.8	0.1	-0.1	0.8
Had major operations	0.4	0.4	1.8	-0.4	0.5	0.1	1.4	0.1	0.6
Age at last live birth	1.4	2.1	4.2	0.5	1.9	1.5	-0.5	1.3	-2.1
Family relationship satisfaction	0.6	0.8	1.9	-0.2	0.6	0.6	1.4	-1.1	0.9
Leg pain on walking	0.4	0.5	1.7	-0.5	-0.8	-1.3	-0.5	-0.4	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.5	0.0	-1.1	-0.3	-1.2	0.6	0.1
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.0	0.2	0.0	-1.0	-0.7	-0.9	-0.7
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.7	1.3	0.6	1.1	-0.0	-0.1	-1.0
Medication: Aspirin	0.6	0.8	1.9	-1.2	-1.4	-0.7	-0.6	0.6	0.7
Supplements: Vitamin C	0.9	1.1	2.3	-1.5	-0.8	-0.3	0.6	0.9	1.5
Knee pain experienced in last month	0.6	0.9	2.2	-0.0	-0.9	-1.1	-1.0	-1.5	-0.3
Hypertension (Self-reported)	0.2	0.6	1.1	0.6	-0.1	0.9	-0.9	-0.8	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	1.9	0.4	1.2	-1.0	0.6	-1.4	-0.4
Illnesses of father: Heart disease	0.7	1.0	1.7	-1.1	-0.7	-1.2	0.2	1.0	1.3
Illnesses of siblings: Diabetes	0.7	0.9	2.7	-0.6	1.2	0.5	1.7	-0.7	0.5
Smoking status: Previous	0.4	0.6	1.1	0.8	0.5	1.1	-0.7	-0.3	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.0	4.3	-1.4	1.2	0.8	1.8	2.1	0.7
Whole body fat-free mass	1.3	7.7	19.6	-4.1	1.6	-0.7	4.4	0.2	2.6
Leg fat-free mass (right)	1.0	5.5	16.6	-3.0	1.7	-0.2	4.1	0.1	2.0
Arm fat percentage (left)	0.6	2.3	9.6	1.7	0.3	0.3	0.0	-3.1	-0.9
Average weekly red wine intake	0.4	0.6	1.7	-0.3	1.3	0.2	0.2	1.1	-0.7
Handedness (chirality/laterality): Left-handed	0.5	0.6	2.1	0.3	0.7	0.0	-0.3	1.4	-1.0
Mood swings	0.1	0.2	0.5	0.7	0.7	0.3	0.3	-0.3	-0.2
Loneliness, isolation	1.3	1.8	3.7	1.9	-1.0	-0.8	-1.9	-1.2	-0.6
Long-standing illness, disability or infirmity	1.3	2.0	4.9	-0.6	-2.2	-2.1	-1.1	-0.3	1.0
Ever had bowel cancer screening	1.5	1.7	3.8	-1.1	-1.7	-1.6	-1.9	-0.5	0.0
Diabetes diagnosed by doctor	0.7	1.1	3.5	-0.0	0.3	0.1	1.9	-0.9	1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.7	-0.2	-0.4	1.3	-0.5	0.8	-0.2
Friendships satisfaction	0.7	0.9	2.9	1.7	-0.2	0.4	0.1	-1.6	-0.0
Qualifications: nursing, teaching	1.1	1.7	5.2	-1.6	1.1	0.2	2.3	0.3	1.2
Commuting to job workplace: Walk	0.4	0.4	2.0	1.4	0.0	0.7	-0.0	-0.3	-0.1
Eye problems/disorders: Cataract	0.6	0.7	2.0	1.4	-0.4	-0.7	-1.0	-0.7	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	3.9	-0.6	-1.6	-0.5	-2.0	0.5	0.1
Medication for cholesterol	0.3	0.4	1.3	0.8	0.5	0.3	-0.1	-1.1	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.2	2.5	9.2	3.0	0.4	0.7	-1.2	-1.0	-1.8
Back pain experienced in last month	0.4	0.5	1.0	-1.0	-0.3	-0.6	-0.9	-0.7	-0.5
Mineral and other dietary supplements	1.4	1.9	4.7	2.2	1.1	1.4	-0.1	-0.5	-1.7
Breast cancer (self-reported)	0.7	0.8	1.7	-1.0	-0.0	-0.2	1.3	-1.2	0.9
Asthma (self-reported)	0.3	0.7	1.9	-0.6	1.4	0.3	1.0	-0.4	-0.6
Osteoporosis (self-reported)	1.0	1.2	5.1	-0.7	-1.0	-2.3	-0.5	0.5	0.5
Osteoarthritis (self-reported)	1.0	1.3	6.4	0.5	-0.2	0.7	0.6	-2.5	0.2
Medication: Aspirin	0.9	1.2	3.1	-1.0	-1.8	-0.8	-1.0	0.9	0.7
Medication: Gliclazide	0.2	0.3	0.9	0.4	-0.3	0.2	0.3	-0.9	0.6
Illnesses of father: None of the above (group 1)	0.6	0.8	1.6	1.2	0.3	1.0	0.4	-1.3	-0.2
Smoking status: Current	0.7	1.1	3.6	-1.9	-0.4	-1.6	0.0	-0.2	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.8	4.0	1.4	0.5	2.0	-0.9	1.1	-1.5
Whole body water mass	1.2	7.1	18.0	-3.9	1.4	-0.7	4.2	0.2	2.6
Leg predicted mass (right)	1.0	5.5	16.7	-3.0	1.7	-0.1	4.1	0.1	2.0
Arm fat mass (left)	0.4	1.8	7.7	0.1	0.8	0.1	1.5	-2.8	0.1
Number of self-reported non-cancer illnesses	0.1	0.2	0.8	0.1	-0.2	-0.4	-0.2	-0.9	0.2
Average weekly champagne plus white wine intake	1.1	1.5	3.3	1.8	0.6	0.8	-1.2	-0.3	-1.7
Miserableness	0.9	1.6	4.7	1.9	0.3	0.1	-0.9	2.2	-0.7
Guilty feelings	1.0	1.4	3.7	-1.3	-1.0	-1.4	0.1	0.5	1.9
Wears glasses or contact lenses	0.4	0.5	1.6	0.8	0.5	0.0	0.4	-1.3	-0.6
Ever taken oral contraceptive pill	2.7	3.0	5.7	0.7	2.0	2.1	-0.2	1.8	-2.4
Hearing aid user	2.2	2.5	7.6	0.5	1.8	2.8	1.4	-1.0	-1.1
Mother’s age at death	0.2	0.3	0.8	-0.9	-0.0	0.9	0.3	0.1	0.0
Financial situation satisfaction	0.7	0.8	1.5	1.2	-0.8	-1.0	-0.9	1.1	-0.1
Tinnitus: Yes, now most or all of the time	0.4	0.4	2.0	-0.4	-0.2	0.5	0.1	-1.4	-0.4
Commuting to job workplace: Public transport	1.2	1.5	2.7	-1.5	0.1	1.7	1.2	-1.0	1.2
Eye problems/disorders: Glaucoma	2.3	2.7	4.9	2.1	1.4	2.2	-0.1	0.8	-2.0
Medication: Blood pressure	0.4	0.9	2.0	-0.2	-1.4	-1.0	-1.3	-0.7	-0.2
Pain type(s) experienced in last month: Hip pain	4.8	6.1	11.8	-3.0	-3.4	-3.0	-1.5	-0.8	1.9
Supplements: Fish oil (including cod liver oil)	0.8	1.0	2.4	-1.2	-0.9	-0.9	0.2	0.8	1.6
High cholesterol (Self-reported)	0.2	0.4	1.2	-1.1	-0.6	-0.2	0.3	0.7	0.4
Medication: Bendroflumethiazide	0.8	1.3	3.3	-0.8	-1.8	-1.4	-1.0	0.2	0.8
Medication: Paracetamol	0.6	0.9	1.4	0.8	-1.2	-0.9	-0.1	-1.1	1.1
Medication: Lisinopril	0.5	0.6	1.7	0.2	-1.1	1.3	-0.4	-0.6	0.2
Medication: Atorvastatin	0.5	0.6	1.4	-1.0	-1.2	-0.6	-0.6	-0.6	0.4
Illnesses of father: High blood pressure	1.0	1.2	3.0	-0.3	-0.2	-1.3	-1.7	1.0	-1.2
Alcohol drinker status: Never	0.9	1.0	3.6	1.9	0.7	1.0	-0.1	0.2	-1.0
Ever smoked	0.2	0.3	0.7	-0.9	0.2	-0.1	-0.6	-0.6	-0.5
Basal metabolic rate	1.1	6.0	17.1	-3.3	1.6	-0.4	4.1	-0.3	2.3
Leg fat percentage (left)	0.5	1.7	6.9	1.2	-0.8	-0.8	-0.6	-2.6	-0.3
Arm fat-free mass (left)	1.1	5.7	13.8	-3.5	1.0	-1.1	3.7	-0.4	2.5
Number of operations (self-reported)	0.4	0.6	1.3	-0.7	-0.9	-1.2	-0.0	-0.3	0.9
Average weekly beer plus cider intake	0.5	0.7	1.8	-1.4	-0.4	-0.8	0.6	0.5	1.0
Irritability	0.1	0.2	0.4	-0.6	-0.2	-0.5	-0.1	0.5	-0.0
Risk taking	0.4	0.5	1.7	-1.1	-0.3	-1.3	-0.1	0.2	0.3
Ever had prostate specific antigen (PSA) test	0.0	0.0	0.1	-0.1	0.0	0.3	-0.3	-0.1	-0.1
Fractured/broken bones in last 5 years	2.1	2.7	5.0	-1.2	-1.8	-1.8	-1.2	2.2	1.3
Age started oral contraceptive pill	1.1	1.4	3.8	-1.9	-1.6	-0.6	-0.6	0.7	0.9
Diastolic blood pressure, automated reading	1.0	3.0	7.5	-2.7	-1.6	-1.7	0.2	-0.5	2.2
Ever depressed for a whole week	0.4	0.6	1.2	0.6	-1.0	-0.5	-0.5	1.1	0.2
Unable to work because of sickness or disability	0.8	1.0	2.4	0.6	0.5	-0.9	-1.3	0.9	-1.5
Commuting to job workplace: Cycle	0.3	0.4	0.9	0.9	0.1	0.8	-0.5	0.5	-0.5
Myopia	0.1	0.2	0.6	-0.8	-0.2	-0.4	0.2	-0.1	0.4
Vascular/heart problems diagnosed by doctor	0.1	0.4	0.7	-0.4	0.2	-0.5	0.9	0.7	0.8
Cholesterol lowering medication	0.3	0.4	0.8	-0.9	-0.2	-0.5	0.9	0.8	0.4
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.4	-0.5	0.3	-1.0	-1.0	-0.2	-1.2
Pain experienced in last month	0.1	0.2	0.3	0.3	0.4	0.1	0.5	0.6	0.4
Supplements: Calcium	0.7	0.8	1.7	-1.1	-0.7	-1.3	0.3	-0.5	1.1
Basal cell carcinoma (self-reported)	1.1	1.3	3.5	-1.9	-0.9	-0.7	-0.0	-1.1	1.2
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.0	0.9	-0.6	-0.2	-1.0	0.5	-0.3
Deep venous thrombosis (DVT) (self-reported)	1.6	2.1	4.1	1.9	2.0	1.3	1.2	-0.0	-1.4
Heart disease (siblings)	0.1	0.2	0.3	0.5	0.4	0.1	-0.3	-0.4	-0.6
Alcohol drinker status: Previous	0.5	0.5	1.2	0.2	0.9	1.1	1.0	-0.1	-0.3
Pack years of smoking	1.3	1.9	5.0	-0.4	-2.2	-1.9	-1.3	0.4	0.9
Impedance of whole body	0.2	0.9	2.5	1.2	-0.6	0.3	-1.6	0.8	-0.5
Leg fat mass (left)	0.3	1.3	5.2	-0.3	-0.4	-0.8	1.0	-2.3	0.9
Arm predicted mass (left)	1.0	4.9	13.0	-3.1	1.2	-0.9	3.6	-0.4	2.1