Hub : Genes

SKIV2L2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.114 0.0430 2.4e-05 0.043 NA 0.080 NA 0.040 2.1e-03 NA 3.4e-05 NA 2.8e-03
2 GTEx Artery Tibial 0.159 0.0472 1.1e-06 0.082 NA 0.059 NA 0.077 5.2e-07 NA 2.2e-05 NA 1.1e-06
3 GTEx Cells Transformed fibroblasts 0.084 0.0390 1.5e-03 0.067 NA 0.068 NA 0.062 9.5e-06 NA 8.0e-06 NA 1.9e-05
4 GTEx Testis 0.243 0.0700 1.2e-05 0.142 NA 0.106 NA 0.116 7.2e-07 NA 1.9e-05 NA 8.1e-06
5 GTEx Whole Blood 0.102 0.0450 5.1e-03 0.028 NA 0.029 NA 0.035 1.1e-03 NA 9.7e-04 NA 3.6e-04
6 TCGA Ovarian Serous Cystadenocarcinoma 0.064 0.0390 3.5e-04 0.043 0.032 0.028 NA 0.022 7.2e-04 0.0028 5.4e-03 NA 1.1e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.6 0.9 1.9 -0.4 -1.4 -1.1 -1.0 -0.7 0.8
Bipolar Disorder or Schizophrenia 0.1 0.2 0.6 -0.8 -0.1 0.0 0.2 -0.7 0.5
Depressed Affect (Nagel 2018) 0.3 0.5 1.9 1.4 -0.6 0.1 -0.8 0.5 -0.3
Depression (Nagel 2018) 0.7 1.0 4.6 0.7 0.8 0.3 -0.0 2.1 -0.3
Intelligence (Savage-Jansen 2018) 0.2 0.6 2.5 -1.6 -0.6 -0.1 0.5 0.2 0.8
Neuroticism (Nagel 2018) 0.1 0.2 0.4 -0.0 -0.3 0.4 -0.5 0.6 -0.1
Schizophrenia (2018) 0.2 0.5 1.2 -0.7 1.0 0.6 1.1 -0.1 -0.0
Schizophrenia vs Biploar Disorder 0.2 0.3 0.8 0.2 0.9 -0.1 0.3 -0.6 -0.5
Worry (Nagel 2018) 0.3 0.7 1.8 -1.3 -0.7 -0.2 -0.6 1.1 0.4
Alzheimer’s Disease (in mother) 3.9 4.6 8.2 -2.4 -2.9 -2.7 -0.7 -0.1 2.4
Alzheimer’s Disease (in father) 4.1 4.5 10.4 -1.1 -2.7 -3.2 -1.6 1.7 1.5
Alzheimer’s Disease (including proxy) 4.0 5.8 10.7 -2.4 -3.0 -3.3 -0.5 1.2 2.8
Crohns Disease (2017) 0.7 1.6 2.5 -0.6 -1.6 -1.4 -0.7 1.4 1.6
Irritable Bowel Disease (IBD) 1.3 3.1 5.9 -1.5 -2.4 -2.0 -0.9 0.4 2.3
Ulcerative Colitis (UC) 1.1 2.1 3.9 -1.6 -1.9 -1.5 -0.3 -0.1 2.0
Major Depression (MDD) 0.9 1.1 2.7 -1.1 0.0 -0.7 1.0 1.7 1.1
Reaction Time 0.4 0.8 1.6 1.1 0.9 1.0 -0.4 0.3 -1.2
Verbal and Numeric Reasoning (VNR) 0.1 0.1 0.5 -0.7 -0.2 -0.0 0.0 0.5 0.1
Breast Cancer 0.4 0.9 2.3 1.5 -0.2 0.9 -0.7 0.5 -1.1
Ovarian Cancer 0.8 1.1 3.4 -0.3 -1.2 -0.8 -0.9 -1.8 0.4
Prostate Cancer 0.6 0.8 1.6 -0.1 1.3 0.9 1.2 0.8 -0.6
Age at First Birth 1.0 1.4 4.5 -1.0 1.1 -0.6 2.1 0.0 1.2
Bipolar Disorder (2011) 0.7 0.7 1.7 -0.7 -0.4 -1.3 -0.3 -1.0 0.8
Body Mass Index (BMI) (2010) 0.7 0.9 2.1 -1.0 0.0 -0.6 1.4 -1.0 1.0
Coronary Artery Disease (CAD) 0.4 0.5 1.2 1.1 0.7 -0.6 0.2 -0.9 -0.4
Crohns Disease (2012) 1.0 1.7 3.2 0.1 -1.6 -1.8 -0.8 1.1 1.5
Mean Putamen Volume 3.0 3.4 6.7 -2.0 -1.5 -2.6 0.3 -1.6 2.2
Fasting Glucose 0.4 0.5 1.4 0.3 0.6 -0.4 -0.7 -1.2 -0.6
HbA1C 1.3 1.4 4.2 -2.1 0.1 0.9 1.5 0.3 1.1
HDL Cholesterol 0.2 0.3 1.4 0.5 -0.0 -1.2 -0.2 -0.4 -0.2
LDL Cholesterol 0.3 0.4 1.4 0.3 -0.2 0.1 0.7 -1.2 0.7
Lupus 1.2 1.8 4.5 0.3 1.2 1.7 2.1 -1.4 0.4
Neuroticism (2016) 1.1 1.6 3.9 -1.0 -1.1 -1.1 0.8 1.4 2.0
Primary Biliary Cirrhosis 0.2 0.3 0.6 0.8 0.6 0.8 0.4 0.2 -0.4
Rheumatoid Arthritis 0.7 1.0 3.2 1.3 0.8 -0.2 0.5 -1.8 -0.5
Schizophrenia (2014) 0.1 0.3 1.1 -1.0 0.1 0.0 0.6 -0.4 0.5
Triglycerides 0.5 0.9 2.0 -1.3 -0.2 -0.0 1.2 -0.3 1.4
Type 2 Diabetes (T2D) (2012) 0.8 0.9 2.7 -0.7 1.6 0.8 1.3 0.2 -0.1
Ulcerative Colitis 1.1 1.6 4.2 -0.5 -1.7 -2.1 -1.1 -0.3 0.9
Blood Eosinophil Count 0.7 5.7 11.2 3.4 1.5 2.0 -2.4 -0.2 -3.3
Blood Platelet Count 0.2 2.8 8.8 -3.0 -0.1 0.9 1.9 -0.9 1.7
Blood Red Count 0.2 1.5 4.0 -1.4 0.4 -1.1 2.0 0.3 1.3
Blood White Count 0.5 3.7 11.6 -3.4 -0.6 -1.7 1.6 0.5 2.1
Heel T-Score 6.0 47.4 82.3 7.0 8.9 8.4 1.6 0.5 -9.1
BMI 0.3 2.0 11.2 0.4 0.4 0.1 0.5 -3.4 -0.1
Height 1.5 28.8 58.2 -7.0 3.2 0.1 7.6 5.5 5.0
Waist Hip Ratio (WHR) 2.0 9.1 22.8 -3.9 -1.5 -2.0 3.1 0.2 4.8
Systolic Blood Pressure 0.1 0.5 1.5 -1.2 -0.2 0.6 0.2 -0.0 0.9
Smoking Status 0.1 0.3 0.6 -0.4 0.5 0.0 -0.7 0.5 -0.8
Allergy or Eczema 0.6 1.6 3.1 1.8 1.3 1.3 0.6 -1.2 -1.1
Cardiovascular Disease 0.1 0.2 0.9 -0.5 -0.5 0.2 -0.0 0.9 0.1
Hypothyroidism (self reported) 1.9 4.4 10.1 -0.2 -3.2 -3.1 -1.9 -0.3 1.8
Respiratory disease 0.8 1.7 4.5 -1.8 0.8 -0.6 2.1 -0.4 1.1
Type 2 Diabetes (T2D) (2018) 0.5 1.0 2.6 -0.8 0.2 0.1 1.6 -0.8 1.4
Lung FEV1/FVC ratio 0.6 3.1 7.2 2.4 -0.5 0.8 -2.7 1.0 -2.0
Lung FVC 1.1 5.7 11.3 2.9 1.8 3.4 -1.1 0.8 -3.1
Neuroticism 0.4 0.9 2.2 -0.9 -1.5 -0.6 -0.6 -0.5 1.2
Chronotype (morning person) 0.6 1.3 2.5 1.2 -1.2 -1.5 -1.6 0.3 -0.4
Hair Pigment 0.0 0.6 2.2 -0.4 0.5 0.0 0.9 -1.5 0.3
Tanning 0.0 0.2 0.9 0.4 -0.2 0.3 -0.1 -1.0 0.1
Hand grip strength (left) 0.3 0.9 2.7 -0.6 1.4 0.6 1.7 -0.1 -0.3
Number of treatments/medications taken 0.5 1.0 1.9 -0.8 0.0 -1.0 1.4 -0.9 1.3
Average weekly spirits intake 0.5 0.6 1.5 -0.6 -0.7 -1.0 0.4 -0.1 1.2
Sensitivity / hurt feelings 0.7 1.2 4.5 0.1 -1.2 -0.5 -2.1 -0.7 -0.7
Frequency of depressed mood in last 2 weeks 0.2 0.2 0.6 0.8 -0.2 -0.5 -0.2 0.5 0.5
Hearing difficulty/problems: Yes 0.7 1.1 1.9 1.3 0.4 1.4 -0.6 0.6 -1.4
Relative age of first facial hair 0.8 1.7 3.6 -1.9 -1.2 -1.6 0.2 0.2 1.7
Other serious medical condition/disability diagnosed by doctor 1.2 1.6 3.5 -0.2 -1.9 -1.6 -1.7 -0.7 0.4
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.1 -0.5 0.2 0.2 1.1 -0.5 0.6
Ever had hysterectomy (womb removed) 1.8 2.0 4.6 -1.1 -2.1 -1.1 0.0 -0.8 2.1
Systolic blood pressure, automated reading 0.7 2.0 3.8 -1.9 -1.9 -1.3 -1.0 0.4 1.3
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 0.9 -0.0 0.9 0.9 0.8 0.2 -0.0
Angina 0.3 0.5 1.2 0.0 0.5 -0.7 -0.4 0.8 -1.1
Medication for hormone replacement therapy 1.0 1.1 3.3 -0.1 -1.1 -1.3 -0.7 1.8 0.4
Vitamin and mineral supplements 1.4 1.9 4.4 2.1 1.0 0.8 -1.0 0.5 -2.0
Supplements: Zinc 2.1 2.2 6.6 -2.6 -1.1 -1.9 -0.5 0.4 1.3
Medication: Co-codamol 2.2 2.6 7.5 -0.1 -0.7 -1.2 -2.7 1.7 -1.7
Medication: Metformin 0.2 0.3 1.0 -0.0 -0.3 -0.0 0.8 -0.2 1.0
Diabetes (father) 1.4 1.8 4.2 -2.1 -1.4 -1.3 -0.2 -0.2 1.6
Diabetes (mother) 1.5 2.0 3.1 1.7 1.7 1.5 0.4 0.7 -1.8
Severe depression (siblings) 0.5 0.6 1.9 -1.4 -0.1 -0.3 1.0 0.0 0.8
Pack years adult smoking proportion 1.3 2.1 5.2 -0.4 -2.3 -2.1 -1.3 0.2 0.9
Impedance of leg (right) 0.3 1.2 3.9 0.8 -1.5 -0.7 -2.0 0.5 0.1
Leg fat-free mass (left) 1.0 5.4 16.2 -3.0 1.6 -0.4 4.0 0.1 2.1
Trunk fat percentage 0.4 1.6 7.5 1.4 0.0 0.0 0.1 -2.7 -0.5
Hand grip strength (right) 0.4 1.1 1.8 -1.2 1.3 1.1 1.3 0.7 -0.6
Townsend deprivation index at recruitment 1.0 1.4 2.4 1.1 -1.4 -1.5 -1.5 -0.8 -0.1
Current tobacco smoking 0.7 1.1 3.3 -1.8 -0.6 -1.7 -0.0 0.2 0.6
Average weekly fortified wine intake 0.6 0.7 2.3 -0.5 0.6 0.5 1.5 -0.7 0.6
Maternal smoking around birth 0.1 0.1 0.2 0.2 0.5 0.1 0.1 -0.4 -0.3
Fed-up feelings 0.1 0.2 0.6 -0.0 -0.7 -0.8 -0.4 0.1 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 1.0 4.9 0.1 0.7 0.1 0.5 2.2 0.2
Relative age voice broke 0.5 0.7 1.6 0.5 0.8 0.9 0.2 1.3 -1.0
Taking other prescription medications 0.5 0.7 2.1 0.6 0.4 -0.8 0.9 -1.5 0.2
Age when periods started (menarche) 0.1 0.3 0.7 -0.7 0.1 0.5 0.7 -0.2 0.8
Bilateral oophorectomy (both ovaries removed) 1.5 1.7 4.8 -1.0 -0.7 -1.1 1.6 -0.1 2.2
Heel bone mineral density (BMD) T-score, automated (left) 6.1 13.9 28.9 2.8 5.4 5.0 2.9 -0.8 -3.5
Tinnitus: Yes, but not now, but have in the past 0.5 0.6 1.9 0.2 -0.6 -0.2 -1.4 1.0 -0.4
Qualifications: CSEs or equivalent 1.1 1.4 5.1 0.9 -0.9 -0.6 -1.2 2.3 -0.1
Serious illness, injury or assault to yourself 1.0 1.2 2.4 -1.6 -0.9 -1.5 -0.8 1.0 0.3
High blood pressure 0.2 0.6 1.2 0.7 0.0 1.1 -0.7 -0.8 -1.1
Hayfever, allergic rhinitis or eczema 0.7 1.4 2.3 1.5 0.9 1.1 -0.5 -1.3 -1.5
Multivitamins +/- minerals 2.2 2.7 7.7 -2.8 -0.9 -1.2 1.3 -0.3 2.2
Stomach or abdominal pain in last month 0.2 0.2 0.8 -0.1 -0.5 -0.9 -0.5 -0.2 0.1
Supplements: Glucosamine 0.6 0.8 2.6 -1.6 -0.5 -0.3 -0.6 -1.0 0.4
Diverticular disease/diverticulitis (self-reported) 2.2 2.6 6.5 -0.3 -2.3 -2.5 -1.3 -0.9 1.2
Medication: Atenolol 1.0 1.3 2.8 -0.7 -1.7 -1.4 -1.6 0.1 0.3
Medication: Levothyroxine sodium 0.9 1.5 3.5 -0.6 -1.7 -1.9 -0.4 -0.4 1.4
Sitting height 1.9 13.4 29.2 -5.4 1.4 -1.3 5.0 2.6 4.0
Chronic bronchitis/emphysema (father) 0.4 0.4 1.4 0.3 0.9 0.4 -0.0 -0.0 -1.2
High blood pressure (mother) 1.4 1.9 6.3 1.1 0.6 0.3 -0.9 2.5 -1.7
Body mass index (BMI) 0.5 2.0 9.2 1.2 0.5 0.1 0.7 -3.0 -0.6
Impedance of leg (left) 0.2 1.2 3.8 0.5 -1.6 -0.6 -1.9 0.3 0.1
Leg predicted mass (left) 1.0 5.2 15.7 -2.9 1.5 -0.4 4.0 0.1 2.2
Trunk fat mass 0.3 1.3 5.6 0.1 0.4 -0.1 1.4 -2.4 0.4
Waist circumference 0.2 0.9 2.4 -0.3 0.1 -0.3 1.5 -1.5 0.9
Number of incorrect matches in round 0.4 0.7 2.2 0.2 -1.3 0.1 -1.5 0.5 0.1
Past tobacco smoking 0.3 0.5 1.2 -0.1 -0.3 -0.8 1.0 0.7 1.1
Alcohol usually taken with meals 0.2 0.4 0.9 -0.9 -0.6 -0.7 -0.2 -0.4 0.4
Nervous feelings 0.4 0.7 1.6 -1.3 -0.6 -0.4 -0.8 1.2 0.2
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.6 3.9 -0.7 0.6 -0.7 2.0 1.9 1.1
Hearing difficulty/problems with background noise 1.0 1.7 3.7 1.9 1.4 1.3 -0.2 -0.2 -1.6
Hair/balding pattern: Pattern 2 2.7 3.5 7.5 1.7 2.7 1.7 2.2 -1.5 -0.5
Had menopause 2.5 3.1 7.1 -2.1 -1.3 -1.8 0.2 -2.7 1.6
Had other major operations 2.1 2.6 8.9 -0.3 -1.8 -3.0 -0.9 -0.3 1.5
Forced vital capacity (FVC) 1.2 4.5 8.7 -0.8 2.5 2.2 3.0 2.7 0.2
Heel bone mineral density (BMD) T-score, automated (right) 6.0 13.7 26.6 3.2 5.2 5.0 2.4 -0.5 -3.8
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 0.8 0.1 -0.2 -0.0 0.7 0.9 0.5
Qualifications: None of the above 1.1 2.5 6.3 2.5 0.1 1.3 -1.3 -1.4 -1.8
Financial difficulties in last 2 years 2.1 2.9 6.2 -0.5 -2.1 -2.3 -2.5 0.9 0.1
Mouth/teeth dental problems 0.6 1.0 3.3 0.9 1.0 0.4 1.8 -0.6 0.2
Heart attack 0.6 0.7 1.9 1.2 -0.6 -0.1 -1.4 0.6 -0.6
Allergy 0.6 1.3 2.1 -1.1 -1.4 -1.1 -0.5 1.0 1.4
Pain all over the body in last month 1.4 1.5 3.8 1.7 1.1 0.5 -0.9 0.3 -2.0
Diabetes (self-reported) 0.3 0.5 1.6 -0.3 -0.2 -0.3 1.1 -0.3 1.3
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 2.0 0.1 -0.9 -0.2 -1.4 -0.4 -0.4
Medication: Ramipril 0.0 0.1 0.2 -0.4 0.2 -0.1 0.0 0.3 0.1
Medication: Simvastatin 0.5 0.7 1.7 -0.2 -1.3 -0.7 -0.1 1.1 0.7
Fluid intelligence score 0.1 0.2 0.8 -0.5 0.2 0.4 0.4 -0.9 -0.0
Illnesses of siblings 0.8 1.1 2.5 -0.6 -1.6 -1.4 -0.5 -0.8 0.9
Neuroticism score 0.2 0.4 0.9 -0.3 -0.9 -0.7 -0.9 -0.3 0.4
Weight 0.6 2.8 9.3 -1.4 1.1 -0.2 3.0 -1.5 1.4
Impedance of arm (right) 0.2 0.7 2.5 0.9 -0.3 0.4 -1.6 0.5 -0.7
Arm fat percentage (right) 0.7 2.7 11.2 1.9 0.4 0.4 -0.3 -3.4 -1.2
Trunk fat-free mass 1.5 8.7 21.0 -4.6 1.4 -0.8 4.5 0.3 2.9
Hip circumference 0.4 1.9 3.2 1.4 1.8 1.1 1.4 -1.4 -1.0
Time employed in main current job 0.5 0.6 1.7 0.6 0.8 -0.2 -0.5 -1.3 -0.8
Alcohol intake versus 10 years previously 0.3 0.5 0.8 0.9 -0.1 0.9 -0.4 0.4 -0.9
Father’s age at death 1.5 2.0 4.3 0.1 1.6 2.1 2.1 1.0 0.2
Worrier / anxious feelings 0.1 0.2 0.7 -0.3 0.1 0.0 0.8 0.3 0.8
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.3 4.2 -0.8 -0.6 -1.4 0.1 2.1 0.7
Falls in the last year 2.3 3.1 7.4 -2.7 -1.7 -2.3 -0.4 -0.4 1.8
Hair/balding pattern: Pattern 3 0.6 0.8 1.6 0.2 -1.2 -1.3 -1.2 -0.6 0.2
Number of live births 1.4 1.9 5.2 1.4 1.3 0.9 -1.1 0.8 -2.3
Forced expiratory volume in 1-second (FEV1) 1.2 4.2 8.6 0.6 2.3 2.6 1.6 2.9 -1.1
Pulse rate 0.4 0.7 1.4 -1.1 -1.2 -0.5 -0.4 0.1 1.0
Happiness 0.5 0.6 1.5 1.2 0.5 0.7 0.7 1.0 -0.0
Noisy workplace 0.8 1.0 2.9 1.7 -0.1 -0.1 -1.4 -0.0 -1.1
Qualifications: A levels/AS levels or equivalent 0.4 0.9 1.8 -1.0 0.8 1.4 1.3 0.1 0.6
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 0.7 -0.8 0.6 -0.4 0.7 -0.4 0.3
Mouth/teeth dental problems: Dentures 0.2 0.4 0.9 -0.2 0.8 0.9 0.8 -0.4 -0.4
Asthma 0.2 0.4 0.9 -0.8 0.9 0.3 0.7 -0.2 -0.4
Medication: Ibuprofen (e.g. Nurofen) 1.7 2.2 5.5 -2.1 -0.8 -0.6 1.5 -0.3 2.3
Medication: Cholesterol lowering 0.2 0.4 0.8 0.5 -0.9 0.3 -0.9 0.5 -0.1
Depression (self-reported) 0.8 1.0 2.4 0.9 -1.0 -0.7 -1.5 1.0 -0.5
Medication: Lansoprazole 2.2 2.6 7.7 -0.2 -1.9 -2.8 -1.4 -1.0 1.1
Prospective memory result 1.2 1.5 4.7 2.2 0.3 -0.2 -1.5 0.4 -1.4
Lung cancer (father) 0.3 0.3 1.3 0.6 0.2 0.2 1.2 -0.4 0.3
Illnesses of mother 0.5 0.7 1.7 1.2 0.5 0.6 0.2 -1.3 -0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.2 6.9 0.3 1.3 1.8 0.9 2.6 -0.4
Pulse wave Arterial Stiffness index 2.9 3.4 6.7 -2.6 -1.9 -2.2 0.2 -0.4 2.2
Impedance of arm (left) 0.1 0.6 1.0 1.0 0.1 0.9 -0.9 0.8 -0.5
Arm fat mass (right) 0.4 1.6 7.8 0.2 0.7 -0.0 1.2 -2.8 -0.1
Trunk predicted mass 1.5 8.8 21.9 -4.7 1.3 -0.9 4.4 0.2 3.0
Standing height 1.7 17.2 38.4 -6.2 1.5 -1.0 5.6 2.8 4.7
Length of working week for main job 0.7 0.7 1.7 0.6 -0.8 -1.2 -0.7 -1.3 0.2
Exposure to tobacco smoke at home 0.2 0.3 0.5 0.6 0.5 -0.6 0.2 0.7 0.1
Breastfed as a baby 0.1 0.1 0.5 -0.7 -0.3 0.3 -0.2 0.1 0.2
Tense / ‘highly strung’ 0.4 0.7 2.6 -0.5 -0.7 -0.8 -1.6 0.6 -0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.4 0.9 0.7 -0.4 -0.9 -0.7 -0.3 0.2
Hair/balding pattern: Pattern 4 0.8 1.8 4.1 -0.9 -2.0 -0.9 -2.0 1.0 0.1
Birth weight of first child 0.9 1.7 4.2 0.9 1.8 0.8 2.0 1.1 -0.3
Peak expiratory flow (PEF) 0.9 2.0 5.4 -1.0 1.4 1.5 2.3 1.1 0.4
Pulse wave reflection index 0.5 0.6 1.5 -0.5 -0.7 -1.1 0.5 0.0 1.2
Ever highly irritable/argumentative for 2 days 1.2 1.4 3.8 -0.3 -1.6 -1.9 -1.1 -0.1 0.8
Loud music exposure frequency 0.9 0.9 2.6 -1.6 -0.9 -0.6 0.3 -0.5 1.3
Qualifications: O levels/GCSEs or equivalent 0.6 1.0 2.3 -1.5 0.7 0.1 1.2 0.9 0.9
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.3 -0.9 0.0 0.1 -1.0 1.1 -0.3
Blood clot in the leg (DVT) 1.1 1.5 2.9 1.6 1.7 1.0 1.1 -0.0 -1.0
Medication: Paracetamol 0.8 1.3 3.7 0.6 -1.3 -0.5 0.2 -1.9 1.4
Headache pain in last month 0.3 0.6 1.1 -0.7 -0.4 -1.0 0.2 1.1 0.8
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 1.0 -0.8 0.5 -1.0 0.8 0.4 0.4
Glaucoma (self-reported) 0.6 0.7 2.4 0.5 0.6 0.6 -0.1 1.5 -1.1
Gout (self-reported) 0.8 1.1 2.4 -0.6 0.9 1.4 1.2 -1.6 0.2
Hypothyroidism/myxoedema (self-reported) 2.3 4.5 10.4 -0.7 -3.1 -3.2 -1.2 -0.5 2.2
Medication: Amlodipine 0.8 1.1 3.2 1.3 -0.6 0.1 -1.2 1.8 -0.4
Medication: Ventolin 100micrograms inhaler 1.2 1.5 3.1 -1.2 -0.8 -1.4 1.0 -1.0 1.8
Birth weight 0.6 1.4 3.7 0.1 1.9 1.4 1.4 0.9 -0.4
Chronic bronchitis/emphysema (mother) 0.3 0.4 1.6 -0.7 -0.1 -1.3 -0.2 0.3 0.2
High blood pressure (siblings) 1.0 1.4 2.8 1.0 1.7 1.4 0.8 1.1 -1.0
Forced vital capacity (FVC), Best measure 0.6 2.3 5.2 -1.1 1.2 1.4 1.9 2.3 0.9
Body fat percentage 0.5 1.8 7.5 1.6 -0.1 -0.0 -0.4 -2.7 -0.8
Leg fat percentage (right) 0.5 1.7 6.4 1.4 -0.8 -0.8 -0.7 -2.5 -0.3
Arm fat-free mass (right) 1.3 6.4 15.8 -3.7 1.0 -1.0 4.0 -0.1 2.7
Exposure to tobacco smoke outside home 0.7 0.9 2.9 -0.6 -0.4 -0.9 -1.1 -1.7 -0.1
Comparative body size at age 10 0.8 2.1 5.6 2.4 1.3 1.1 -0.1 -1.3 -1.5
Number of full brothers 0.8 1.0 2.6 0.9 0.0 0.0 -1.6 0.8 -1.4
Worry too long after embarrassment 1.3 2.2 6.2 0.6 1.9 2.5 1.6 -0.4 -0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 1.8 1.3 0.0 -1.0 -1.1 0.4 -0.8
Wheeze or whistling in the chest in last year 0.2 0.3 0.5 -0.0 0.7 -0.4 0.7 0.7 -0.4
Number of children fathered 0.2 0.2 0.8 0.3 -0.1 0.4 -0.9 -0.3 -0.3
Reason for reducing amount of alcohol drunk: Health precaution 1.9 2.2 3.5 -1.9 -1.4 -1.8 -0.4 1.6 1.3
Age at first live birth 0.8 1.4 3.5 0.2 1.9 0.7 0.1 1.5 -1.5
Pulse wave peak to peak time 2.4 2.9 4.9 2.2 2.0 2.1 0.1 0.6 -1.9
Health satisfaction 1.2 1.6 4.2 -0.6 -1.6 -2.1 -0.3 0.0 1.5
Shortness of breath walking on level ground 0.8 0.9 3.0 0.2 -1.2 -1.7 -1.1 0.1 -0.0
Qualifications: College or University degree 0.4 1.4 3.7 -0.6 1.9 0.6 1.8 0.8 -0.2
Eye problems/disorders: None of the above 0.4 0.5 1.1 -1.0 0.1 0.2 0.9 0.8 0.6
Mouth/teeth dental problems: Loose teeth 2.5 2.9 8.2 1.1 -0.9 -0.3 -2.9 1.8 -2.0
Emphysema/chronic bronchitis 1.7 1.9 4.4 -2.1 -0.9 -1.1 1.3 -0.3 1.8
Medication for pain relief, constipation, heartburn 0.5 0.8 1.6 -0.2 1.3 1.0 0.6 1.1 -0.7
Neck or shoulder pain in last month 0.4 0.6 1.7 -0.9 0.1 0.1 1.3 -0.4 0.9
Medication: Blood pressure 0.9 1.5 3.5 1.3 -0.2 1.3 -1.9 -0.3 -1.4
Angina (self-reported) 0.5 0.6 1.6 -0.1 0.1 -0.8 -0.9 0.9 -1.2
Migraine (self-reported) 0.4 0.5 1.9 -0.6 0.4 0.8 1.4 -0.4 0.2
Medication: Ibuprofen 1.3 1.6 4.3 -1.5 -1.1 -0.9 0.8 -0.5 2.1
Medication: Allopurinol 0.2 0.3 0.8 -0.9 -0.4 0.6 0.0 -0.6 0.4
Medication: Omeprazole 0.8 0.9 2.3 0.3 -0.0 -1.3 -1.5 -0.1 -1.3
Medication: Seretide 50 evohaler 1.1 1.3 4.8 -2.2 -0.6 -1.0 0.2 0.6 1.1
Mean time to correctly identify matches 0.3 0.6 1.0 1.0 0.4 0.8 -0.6 -0.4 -1.0
Heart disease (mother) 1.3 1.5 4.2 -2.0 -0.5 -1.1 0.8 1.0 1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.7 1.6 0.6 1.2 0.5 1.3 0.2 -0.3
Whole body fat mass 0.3 1.3 6.0 -0.2 0.2 -0.3 1.2 -2.4 0.5
Leg fat mass (right) 0.3 1.2 4.5 -0.3 -0.4 -0.9 0.9 -2.1 0.9
Arm predicted mass (right) 1.3 6.5 15.4 -3.9 0.6 -1.5 3.6 0.1 2.8
Pulse rate, automated reading 0.4 1.4 3.6 -1.3 -0.5 -0.6 1.5 -0.5 1.9
Alcohol intake frequency. 0.2 0.4 0.8 0.8 -0.9 -0.2 0.4 -0.3 0.7
Comparative height size at age 10 0.9 5.0 11.0 -3.3 0.3 -1.1 3.0 1.3 2.7
Number of full sisters 1.1 1.3 2.4 1.5 0.9 0.9 -0.6 1.1 -1.5
Suffer from ‘nerves’ 1.3 2.0 4.0 -1.1 -2.0 -1.5 -2.0 -0.7 0.6
Overall health rating 1.1 2.3 6.1 -0.9 -1.8 -2.5 -1.1 -0.6 1.3
Chest pain or discomfort 0.5 0.7 3.1 0.0 -0.7 -1.8 0.1 -0.1 0.8
Had major operations 0.4 0.4 1.8 -0.4 0.5 0.1 1.4 0.1 0.6
Age at last live birth 1.4 2.1 4.2 0.5 1.9 1.5 -0.5 1.3 -2.1
Family relationship satisfaction 0.6 0.8 1.9 -0.2 0.6 0.6 1.4 -1.1 0.9
Leg pain on walking 0.4 0.5 1.7 -0.5 -0.8 -1.3 -0.5 -0.4 0.3
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.5 0.0 -1.1 -0.3 -1.2 0.6 0.1
Commuting to job workplace: Car/motor vehicle 0.4 0.5 1.0 0.2 0.0 -1.0 -0.7 -0.9 -0.7
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 1.7 1.3 0.6 1.1 -0.0 -0.1 -1.0
Medication: Aspirin 0.6 0.8 1.9 -1.2 -1.4 -0.7 -0.6 0.6 0.7
Supplements: Vitamin C 0.9 1.1 2.3 -1.5 -0.8 -0.3 0.6 0.9 1.5
Knee pain experienced in last month 0.6 0.9 2.2 -0.0 -0.9 -1.1 -1.0 -1.5 -0.3
Hypertension (Self-reported) 0.2 0.6 1.1 0.6 -0.1 0.9 -0.9 -0.8 -1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.9 1.9 0.4 1.2 -1.0 0.6 -1.4 -0.4
Illnesses of father: Heart disease 0.7 1.0 1.7 -1.1 -0.7 -1.2 0.2 1.0 1.3
Illnesses of siblings: Diabetes 0.7 0.9 2.7 -0.6 1.2 0.5 1.7 -0.7 0.5
Smoking status: Previous 0.4 0.6 1.1 0.8 0.5 1.1 -0.7 -0.3 -1.0
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.0 4.3 -1.4 1.2 0.8 1.8 2.1 0.7
Whole body fat-free mass 1.3 7.7 19.6 -4.1 1.6 -0.7 4.4 0.2 2.6
Leg fat-free mass (right) 1.0 5.5 16.6 -3.0 1.7 -0.2 4.1 0.1 2.0
Arm fat percentage (left) 0.6 2.3 9.6 1.7 0.3 0.3 0.0 -3.1 -0.9
Average weekly red wine intake 0.4 0.6 1.7 -0.3 1.3 0.2 0.2 1.1 -0.7
Handedness (chirality/laterality): Left-handed 0.5 0.6 2.1 0.3 0.7 0.0 -0.3 1.4 -1.0
Mood swings 0.1 0.2 0.5 0.7 0.7 0.3 0.3 -0.3 -0.2
Loneliness, isolation 1.3 1.8 3.7 1.9 -1.0 -0.8 -1.9 -1.2 -0.6
Long-standing illness, disability or infirmity 1.3 2.0 4.9 -0.6 -2.2 -2.1 -1.1 -0.3 1.0
Ever had bowel cancer screening 1.5 1.7 3.8 -1.1 -1.7 -1.6 -1.9 -0.5 0.0
Diabetes diagnosed by doctor 0.7 1.1 3.5 -0.0 0.3 0.1 1.9 -0.9 1.4
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.5 1.7 -0.2 -0.4 1.3 -0.5 0.8 -0.2
Friendships satisfaction 0.7 0.9 2.9 1.7 -0.2 0.4 0.1 -1.6 -0.0
Qualifications: nursing, teaching 1.1 1.7 5.2 -1.6 1.1 0.2 2.3 0.3 1.2
Commuting to job workplace: Walk 0.4 0.4 2.0 1.4 0.0 0.7 -0.0 -0.3 -0.1
Eye problems/disorders: Cataract 0.6 0.7 2.0 1.4 -0.4 -0.7 -1.0 -0.7 -0.5
Mouth/teeth dental problems: Mouth ulcers 0.8 1.2 3.9 -0.6 -1.6 -0.5 -2.0 0.5 0.1
Medication for cholesterol 0.3 0.4 1.3 0.8 0.5 0.3 -0.1 -1.1 -0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.2 2.5 9.2 3.0 0.4 0.7 -1.2 -1.0 -1.8
Back pain experienced in last month 0.4 0.5 1.0 -1.0 -0.3 -0.6 -0.9 -0.7 -0.5
Mineral and other dietary supplements 1.4 1.9 4.7 2.2 1.1 1.4 -0.1 -0.5 -1.7
Breast cancer (self-reported) 0.7 0.8 1.7 -1.0 -0.0 -0.2 1.3 -1.2 0.9
Asthma (self-reported) 0.3 0.7 1.9 -0.6 1.4 0.3 1.0 -0.4 -0.6
Osteoporosis (self-reported) 1.0 1.2 5.1 -0.7 -1.0 -2.3 -0.5 0.5 0.5
Osteoarthritis (self-reported) 1.0 1.3 6.4 0.5 -0.2 0.7 0.6 -2.5 0.2
Medication: Aspirin 0.9 1.2 3.1 -1.0 -1.8 -0.8 -1.0 0.9 0.7
Medication: Gliclazide 0.2 0.3 0.9 0.4 -0.3 0.2 0.3 -0.9 0.6
Illnesses of father: None of the above (group 1) 0.6 0.8 1.6 1.2 0.3 1.0 0.4 -1.3 -0.2
Smoking status: Current 0.7 1.1 3.6 -1.9 -0.4 -1.6 0.0 -0.2 0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.8 4.0 1.4 0.5 2.0 -0.9 1.1 -1.5
Whole body water mass 1.2 7.1 18.0 -3.9 1.4 -0.7 4.2 0.2 2.6
Leg predicted mass (right) 1.0 5.5 16.7 -3.0 1.7 -0.1 4.1 0.1 2.0
Arm fat mass (left) 0.4 1.8 7.7 0.1 0.8 0.1 1.5 -2.8 0.1
Number of self-reported non-cancer illnesses 0.1 0.2 0.8 0.1 -0.2 -0.4 -0.2 -0.9 0.2
Average weekly champagne plus white wine intake 1.1 1.5 3.3 1.8 0.6 0.8 -1.2 -0.3 -1.7
Miserableness 0.9 1.6 4.7 1.9 0.3 0.1 -0.9 2.2 -0.7
Guilty feelings 1.0 1.4 3.7 -1.3 -1.0 -1.4 0.1 0.5 1.9
Wears glasses or contact lenses 0.4 0.5 1.6 0.8 0.5 0.0 0.4 -1.3 -0.6
Ever taken oral contraceptive pill 2.7 3.0 5.7 0.7 2.0 2.1 -0.2 1.8 -2.4
Hearing aid user 2.2 2.5 7.6 0.5 1.8 2.8 1.4 -1.0 -1.1
Mother’s age at death 0.2 0.3 0.8 -0.9 -0.0 0.9 0.3 0.1 0.0
Financial situation satisfaction 0.7 0.8 1.5 1.2 -0.8 -1.0 -0.9 1.1 -0.1
Tinnitus: Yes, now most or all of the time 0.4 0.4 2.0 -0.4 -0.2 0.5 0.1 -1.4 -0.4
Commuting to job workplace: Public transport 1.2 1.5 2.7 -1.5 0.1 1.7 1.2 -1.0 1.2
Eye problems/disorders: Glaucoma 2.3 2.7 4.9 2.1 1.4 2.2 -0.1 0.8 -2.0
Medication: Blood pressure 0.4 0.9 2.0 -0.2 -1.4 -1.0 -1.3 -0.7 -0.2
Pain type(s) experienced in last month: Hip pain 4.8 6.1 11.8 -3.0 -3.4 -3.0 -1.5 -0.8 1.9
Supplements: Fish oil (including cod liver oil) 0.8 1.0 2.4 -1.2 -0.9 -0.9 0.2 0.8 1.6
High cholesterol (Self-reported) 0.2 0.4 1.2 -1.1 -0.6 -0.2 0.3 0.7 0.4
Medication: Bendroflumethiazide 0.8 1.3 3.3 -0.8 -1.8 -1.4 -1.0 0.2 0.8
Medication: Paracetamol 0.6 0.9 1.4 0.8 -1.2 -0.9 -0.1 -1.1 1.1
Medication: Lisinopril 0.5 0.6 1.7 0.2 -1.1 1.3 -0.4 -0.6 0.2
Medication: Atorvastatin 0.5 0.6 1.4 -1.0 -1.2 -0.6 -0.6 -0.6 0.4
Illnesses of father: High blood pressure 1.0 1.2 3.0 -0.3 -0.2 -1.3 -1.7 1.0 -1.2
Alcohol drinker status: Never 0.9 1.0 3.6 1.9 0.7 1.0 -0.1 0.2 -1.0
Ever smoked 0.2 0.3 0.7 -0.9 0.2 -0.1 -0.6 -0.6 -0.5
Basal metabolic rate 1.1 6.0 17.1 -3.3 1.6 -0.4 4.1 -0.3 2.3
Leg fat percentage (left) 0.5 1.7 6.9 1.2 -0.8 -0.8 -0.6 -2.6 -0.3
Arm fat-free mass (left) 1.1 5.7 13.8 -3.5 1.0 -1.1 3.7 -0.4 2.5
Number of operations (self-reported) 0.4 0.6 1.3 -0.7 -0.9 -1.2 -0.0 -0.3 0.9
Average weekly beer plus cider intake 0.5 0.7 1.8 -1.4 -0.4 -0.8 0.6 0.5 1.0
Irritability 0.1 0.2 0.4 -0.6 -0.2 -0.5 -0.1 0.5 -0.0
Risk taking 0.4 0.5 1.7 -1.1 -0.3 -1.3 -0.1 0.2 0.3
Ever had prostate specific antigen (PSA) test 0.0 0.0 0.1 -0.1 0.0 0.3 -0.3 -0.1 -0.1
Fractured/broken bones in last 5 years 2.1 2.7 5.0 -1.2 -1.8 -1.8 -1.2 2.2 1.3
Age started oral contraceptive pill 1.1 1.4 3.8 -1.9 -1.6 -0.6 -0.6 0.7 0.9
Diastolic blood pressure, automated reading 1.0 3.0 7.5 -2.7 -1.6 -1.7 0.2 -0.5 2.2
Ever depressed for a whole week 0.4 0.6 1.2 0.6 -1.0 -0.5 -0.5 1.1 0.2
Unable to work because of sickness or disability 0.8 1.0 2.4 0.6 0.5 -0.9 -1.3 0.9 -1.5
Commuting to job workplace: Cycle 0.3 0.4 0.9 0.9 0.1 0.8 -0.5 0.5 -0.5
Myopia 0.1 0.2 0.6 -0.8 -0.2 -0.4 0.2 -0.1 0.4
Vascular/heart problems diagnosed by doctor 0.1 0.4 0.7 -0.4 0.2 -0.5 0.9 0.7 0.8
Cholesterol lowering medication 0.3 0.4 0.8 -0.9 -0.2 -0.5 0.9 0.8 0.4
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.4 -0.5 0.3 -1.0 -1.0 -0.2 -1.2
Pain experienced in last month 0.1 0.2 0.3 0.3 0.4 0.1 0.5 0.6 0.4
Supplements: Calcium 0.7 0.8 1.7 -1.1 -0.7 -1.3 0.3 -0.5 1.1
Basal cell carcinoma (self-reported) 1.1 1.3 3.5 -1.9 -0.9 -0.7 -0.0 -1.1 1.2
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.0 0.9 -0.6 -0.2 -1.0 0.5 -0.3
Deep venous thrombosis (DVT) (self-reported) 1.6 2.1 4.1 1.9 2.0 1.3 1.2 -0.0 -1.4
Heart disease (siblings) 0.1 0.2 0.3 0.5 0.4 0.1 -0.3 -0.4 -0.6
Alcohol drinker status: Previous 0.5 0.5 1.2 0.2 0.9 1.1 1.0 -0.1 -0.3
Pack years of smoking 1.3 1.9 5.0 -0.4 -2.2 -1.9 -1.3 0.4 0.9
Impedance of whole body 0.2 0.9 2.5 1.2 -0.6 0.3 -1.6 0.8 -0.5
Leg fat mass (left) 0.3 1.3 5.2 -0.3 -0.4 -0.8 1.0 -2.3 0.9
Arm predicted mass (left) 1.0 4.9 13.0 -3.1 1.2 -0.9 3.6 -0.4 2.1