TWAS hub - CCNO

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0650	0.0220	1.3e-08	0.058	0.074	0.104	0.085	0.102	1.4e-07	2.6e-09	1.3e-12	1.6e-10	2.0e-12
2	ROSMAP	Brain Pre-frontal Cortex	0.1347	0.0367	0.0e+00	0.142	0.135	0.122	0.136	0.139	8.1e-18	5.6e-17	2.3e-15	4.0e-17	1.8e-17
3	TCGA	Cervical Squamous Cell Carcinoma	0.0590	0.0400	3.0e-03	0.030	0.028	0.006	NA	0.012	1.3e-02	1.6e-02	1.5e-01	NA	7.8e-02
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.0331	0.0202	2.7e-03	0.023	0.022	0.022	NA	0.019	1.1e-03	1.6e-03	1.4e-03	NA	2.6e-03
5	TCGA	Brain Lower Grade Glioma	0.0341	0.0177	4.3e-04	0.024	0.026	0.012	NA	0.023	8.3e-04	4.8e-04	1.5e-02	NA	1.1e-03
6	TCGA	Prostate Adenocarcinoma	0.0898	0.0463	2.4e-08	0.056	0.067	0.045	NA	0.059	1.5e-06	1.5e-07	1.5e-05	NA	8.6e-07

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Heel T-Score	5.1	40.9	69.4	4.4	7.6	7.2	0.2	8.3	6.8
Heel bone mineral density (BMD) T-score, automated (right)	4.0	9.3	20.1	1.6	3.5	3.0	-1.2	4.5	3.2
Emphysema/chronic bronchitis	3.5	4.0	5.5	-2.0	-2.3	-2.4	-1.3	-1.5	-2.2
Bilateral oophorectomy (both ovaries removed)	3.4	3.9	7.4	-1.8	-1.9	-2.4	-1.4	-1.3	-2.7
Pain type(s) experienced in last month: Hip pain	3.2	4.0	12.3	-0.7	-2.1	-2.0	1.1	-3.5	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	3.1	6.9	19.1	0.8	2.8	2.3	-1.9	4.4	2.2
Lung FEV1/FVC ratio	3.0	15.4	22.5	4.7	4.1	4.5	3.9	1.0	4.1
Trunk fat-free mass	3.0	17.0	26.5	-4.8	-4.3	-4.2	-5.1	0.3	-4.0
Trunk predicted mass	3.0	17.0	25.7	-4.8	-4.4	-4.2	-5.1	0.2	-4.0
Arm fat-free mass (right)	3.0	15.3	20.6	-4.5	-4.2	-4.1	-4.5	-0.1	-4.1
Blood Eosinophil Count	2.9	22.1	33.2	4.8	5.4	5.4	3.2	2.8	5.8
Whole body fat-free mass	2.9	16.4	25.8	-4.7	-4.2	-4.1	-5.1	0.4	-4.0
Sitting height	2.8	19.9	32.9	-5.3	-4.5	-4.4	-5.7	0.8	-4.2
Medication: Ibuprofen (e.g. Nurofen)	2.8	3.5	4.9	-2.2	-1.9	-2.2	-1.6	-0.8	-2.1
Number of full brothers	2.8	3.5	5.4	2.2	1.9	1.9	1.7	0.8	2.3
Arm predicted mass (right)	2.8	14.2	18.3	-4.3	-4.1	-4.0	-4.2	-0.4	-4.0
Lung FVC	2.7	13.9	20.3	4.2	4.2	4.5	2.7	2.5	3.7
Whole body water mass	2.7	15.5	23.9	-4.6	-4.1	-4.0	-4.9	0.3	-3.9
Ever taken oral contraceptive pill	2.7	3.0	5.4	1.3	1.9	2.3	0.5	1.8	2.0
Alzheimer’s Disease (including proxy)	2.6	3.8	8.3	-1.3	-2.2	-2.2	0.3	-2.9	-1.6
Multivitamins +/- minerals	2.6	3.3	4.9	-1.8	-2.1	-2.1	-1.3	-1.1	-2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.6	3.1	4.4	2.1	1.9	1.9	1.7	0.2	2.1
Arm fat-free mass (left)	2.6	13.2	18.6	-4.3	-3.9	-3.8	-4.3	-0.1	-3.7
Mean Putamen Volume	2.4	2.7	4.2	-1.7	-2.1	-1.9	-1.0	-1.5	-1.5
Leg fat-free mass (left)	2.4	12.8	20.8	-4.1	-3.5	-3.6	-4.6	0.6	-3.6
Leg predicted mass (left)	2.4	12.7	20.1	-4.1	-3.6	-3.6	-4.5	0.5	-3.6
Standing height	2.4	23.5	43.3	-5.9	-4.8	-4.6	-6.6	1.3	-4.1
Mouth/teeth dental problems: Loose teeth	2.4	2.8	8.1	2.0	1.1	1.4	2.8	-1.0	1.0
Leg fat-free mass (right)	2.4	12.9	21.1	-4.2	-3.5	-3.6	-4.6	0.6	-3.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.4	5.0	7.1	2.6	2.2	2.7	1.9	1.2	2.5
Leg predicted mass (right)	2.4	12.5	20.8	-4.1	-3.5	-3.5	-4.6	0.6	-3.6
Basal metabolic rate	2.4	13.1	21.5	-4.2	-3.7	-3.6	-4.6	0.4	-3.5
Age at First Birth	2.3	3.3	6.4	-2.3	-1.5	-1.1	-2.5	1.3	-1.7
Hair/balding pattern: Pattern 2	2.3	2.9	7.0	-1.6	-0.4	-0.2	-2.6	2.6	-1.0
Arm predicted mass (left)	2.3	11.5	17.5	-4.0	-3.5	-3.5	-4.2	0.1	-3.3
Alzheimer’s Disease (in mother)	2.1	2.5	8.5	-0.3	-1.7	-1.4	1.0	-2.9	-0.8
Body Mass Index (BMI) (2010)	2.1	2.9	4.5	-2.1	-1.8	-1.9	-1.9	-0.4	-1.6
Diastolic blood pressure, automated reading	2.1	6.6	9.9	-2.5	-3.2	-2.8	-1.1	-2.4	-3.0
Alzheimer’s Disease (in father)	2.0	2.1	5.7	-0.7	-1.4	-1.4	1.1	-2.4	-1.2
Heart disease (mother)	2.0	2.4	3.6	-1.8	-1.9	-1.6	-1.3	-0.7	-1.7
Major Depression (MDD)	1.9	2.3	3.7	-1.9	-1.5	-1.6	-1.6	-0.3	-1.5
Waist Hip Ratio (WHR)	1.9	8.7	12.4	-3.3	-3.3	-3.5	-3.0	-1.8	-2.5
Diverticular disease/diverticulitis (self-reported)	1.9	2.3	4.8	-0.6	-1.5	-1.7	0.8	-2.2	-1.7
Had menopause	1.9	2.4	3.8	-1.3	-1.9	-1.9	-0.6	-1.6	-1.6
Qualifications: None of the above	1.9	4.0	6.6	2.2	1.9	2.0	2.1	-0.5	2.6
Hypothyroidism/myxoedema (self-reported)	1.9	3.6	12.5	-0.4	-1.8	-1.7	1.2	-3.5	-1.1
Smoking status: Previous	1.9	2.9	4.7	2.2	1.9	1.9	1.4	1.0	1.5
Ovarian Cancer	1.8	2.3	3.6	1.9	1.3	1.2	1.9	-1.4	1.2
Respiratory disease	1.8	3.9	6.7	-2.6	-2.0	-1.9	-2.6	0.1	-1.8
Frequency of tenseness / restlessness in last 2 weeks	1.8	2.7	4.6	-2.1	-1.6	-1.8	-2.0	0.0	-1.4
Number of children fathered	1.8	2.0	3.1	1.8	1.5	1.7	1.7	-0.3	1.0
Height	1.7	32.1	72.3	-7.1	-4.8	-4.6	-8.5	2.9	-4.3
Pulse wave Arterial Stiffness index	1.7	2.0	5.7	-1.1	-1.8	-1.3	-0.1	-2.4	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	3.8	-1.1	-1.8	-1.6	-0.2	-2.0	-1.2
Comparative height size at age 10	1.7	9.4	13.5	-3.7	-3.5	-3.2	-3.5	-0.0	-2.9
Average weekly champagne plus white wine intake	1.7	2.4	4.1	1.3	1.7	1.8	1.0	1.1	2.0
Past tobacco smoking	1.6	2.9	5.3	-2.3	-1.7	-1.9	-1.8	-0.5	-1.4
Loud music exposure frequency	1.6	1.8	3.4	-1.2	-1.6	-1.3	-0.6	-1.0	-1.8
Medication: Ventolin 100micrograms inhaler	1.6	2.0	2.7	-1.5	-1.5	-1.4	-1.0	-1.4	-1.6
Medication: Blood pressure	1.6	2.9	4.8	2.0	1.5	1.7	2.2	-0.8	1.6
Financial difficulties in last 2 years	1.5	2.0	5.1	1.4	0.3	0.2	2.3	-1.8	1.2
Pulse wave reflection index	1.5	1.8	2.9	-1.6	-1.7	-1.5	-0.9	-1.0	-1.2
Illnesses of father: Heart disease	1.5	2.1	3.3	-1.6	-1.6	-1.6	-1.1	-0.8	-1.8
Pack years adult smoking proportion	1.4	2.2	6.0	-0.9	-1.7	-1.5	0.6	-2.5	-0.8
Pain all over the body in last month	1.4	1.5	3.7	1.1	1.2	1.4	0.7	0.5	1.9
Medication: Lansoprazole	1.4	1.6	4.2	-0.7	-1.5	-1.4	0.5	-2.0	-0.8
Pulse wave peak to peak time	1.4	1.6	5.8	0.7	1.5	1.0	-0.2	2.4	0.4
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	4.2	1.4	0.8	1.2	2.1	-1.2	1.8
Eye problems/disorders: Glaucoma	1.4	1.7	3.1	0.9	1.4	1.2	0.2	1.6	1.8
Pack years of smoking	1.4	2.0	6.0	-0.8	-1.6	-1.4	0.7	-2.4	-0.8
Average weekly fortified wine intake	1.3	1.6	3.7	-1.6	-0.9	-1.0	-1.9	0.7	-0.9
Medication: Atenolol	1.3	1.6	6.8	0.5	-0.7	-0.3	1.4	-2.6	0.6
Weight	1.3	6.4	10.6	-2.9	-2.5	-2.6	-3.2	0.0	-2.6
Hearing difficulty/problems: Yes	1.2	1.8	3.2	1.5	1.5	1.4	1.1	-0.0	1.8
Ever used hormone-replacement therapy (HRT)	1.2	1.6	2.6	-1.6	-1.1	-1.3	-1.4	0.2	-1.4
Medication: Levothyroxine sodium	1.2	2.1	5.1	-0.7	-1.6	-1.5	0.3	-2.3	-1.4
Depression (self-reported)	1.2	1.5	3.2	1.1	0.6	0.8	1.8	-1.1	1.4
Age at last live birth	1.2	1.8	5.2	0.6	1.6	1.4	-0.1	2.3	0.9
Long-standing illness, disability or infirmity	1.2	1.8	7.8	0.0	-0.9	-1.0	1.0	-2.8	-0.2
Fasting Glucose	1.1	1.3	2.8	1.4	1.2	1.0	0.6	0.4	1.7
Hypothyroidism (self reported)	1.1	2.6	10.2	0.4	-0.8	-0.8	1.9	-3.2	-0.4
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	2.0	1.3	1.2	0.9	1.4	-0.3	1.0
Hayfever, allergic rhinitis or eczema	1.1	2.3	4.7	1.3	1.7	1.8	0.7	1.0	2.2
Hearing difficulty/problems with background noise	1.1	1.8	3.4	1.1	1.8	1.6	0.5	0.8	1.7
Falls in the last year	1.1	1.4	3.1	-0.9	-1.5	-1.3	-0.2	-1.8	-0.8
Number of treatments/medications taken	1.0	1.8	2.3	-1.5	-1.4	-1.5	-1.5	-0.8	-1.2
Supplements: Zinc	1.0	1.1	1.9	-0.9	-1.3	-1.1	-0.2	-1.4	-0.9
Mouth/teeth dental problems	1.0	1.6	2.8	-1.4	-1.0	-1.3	-1.7	0.8	-1.1
Ever had bowel cancer screening	1.0	1.1	3.6	0.4	-0.6	-0.1	1.6	-1.9	0.1
Breast cancer (self-reported)	1.0	1.2	2.5	-1.1	-0.9	-1.1	-1.3	0.1	-1.6
Medication: Aspirin	1.0	1.3	5.1	0.1	-1.0	-0.7	1.1	-2.3	-0.4
Supplements: Fish oil (including cod liver oil)	1.0	1.3	2.2	-1.0	-1.4	-1.3	-0.5	-0.8	-1.5
Illnesses of father: High blood pressure	1.0	1.2	2.8	1.4	0.8	0.9	1.7	-0.7	0.9
Average weekly beer plus cider intake	1.0	1.5	2.6	-1.0	-1.6	-1.5	-0.8	-1.1	-1.0
Age started oral contraceptive pill	1.0	1.3	2.5	-0.8	-1.3	-1.1	0.2	-1.6	-1.2
Qualifications: CSEs or equivalent	0.9	1.3	1.9	1.4	0.9	1.0	1.4	0.7	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	2.4	-1.4	-1.4	-1.6	-0.7	-1.0	-1.0
Forced expiratory volume in 1-second (FEV1)	0.9	2.9	8.7	0.9	1.5	1.6	-0.6	2.9	1.6
Qualifications: College or University degree	0.9	2.7	6.9	-1.8	-0.7	-0.9	-2.6	1.9	-1.1
Medication: Ibuprofen	0.9	1.1	1.8	-1.2	-1.1	-1.3	-0.7	-0.9	-1.1
Chest pain or discomfort	0.9	1.3	2.1	-1.4	-1.4	-1.4	-0.8	-1.0	-0.5
Family relationship satisfaction	0.9	1.2	2.4	-1.0	-0.7	-0.8	-1.4	0.5	-1.6
Medication: Aspirin	0.9	1.1	3.6	-0.4	-1.2	-0.9	0.4	-1.9	-0.7
Illnesses of siblings: Diabetes	0.9	1.2	2.6	-0.9	-0.5	-0.6	-1.6	1.0	-1.4
Ever had prostate specific antigen (PSA) test	0.9	1.0	1.7	1.2	1.1	1.3	0.9	0.6	0.5
Cholesterol lowering medication	0.9	1.4	2.0	-1.4	-1.3	-1.4	-1.2	-0.6	-0.9
Chronotype (morning person)	0.8	1.8	3.9	1.1	0.2	0.6	2.0	-1.7	1.5
Vitamin and mineral supplements	0.8	1.1	1.7	0.9	1.2	1.3	0.8	0.8	1.1
Current tobacco smoking	0.8	1.3	2.6	-0.9	-1.5	-1.0	-0.2	-1.6	-0.9
Time employed in main current job	0.8	0.9	1.6	0.9	1.0	1.2	0.3	0.9	1.3
Father’s age at death	0.8	1.1	3.4	-0.5	0.5	0.1	-1.6	1.8	0.2
Prospective memory result	0.8	1.0	2.1	0.8	1.1	1.0	1.0	0.1	1.5
Shortness of breath walking on level ground	0.8	0.9	4.2	0.2	-0.4	-0.5	1.0	-2.0	0.0
Suffer from ‘nerves’	0.8	1.2	4.7	-0.3	-1.1	-0.7	1.0	-2.2	-0.2
Smoking status: Current	0.8	1.2	2.4	-0.9	-1.6	-1.0	-0.3	-1.5	-0.9
Wears glasses or contact lenses	0.8	0.9	1.7	-1.3	-0.9	-1.0	-0.9	-0.7	-0.9
Medication: Bendroflumethiazide	0.8	1.2	4.5	0.1	-1.0	-0.9	0.9	-2.1	-0.1
Medication: Lisinopril	0.8	1.0	2.3	1.5	1.0	0.6	1.4	-0.5	0.2
Lupus	0.7	1.0	2.7	-0.8	0.2	-0.0	-1.7	1.5	-0.5
Neuroticism (2016)	0.7	1.1	2.0	-0.9	-1.2	-1.1	-0.6	-0.8	-1.4
Primary Biliary Cirrhosis	0.7	1.0	1.4	0.9	1.2	1.2	0.4	0.8	1.2
Triglycerides	0.7	1.1	1.8	-1.1	-1.3	-1.0	-1.1	-0.2	-1.1
Sensitivity / hurt feelings	0.7	1.2	3.5	0.9	0.3	0.3	1.9	-1.5	0.6
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	3.9	-0.0	-0.4	-0.5	1.0	-2.0	0.3
Diabetes (father)	0.7	0.9	3.0	-0.5	-0.9	-0.9	0.1	-1.7	-0.7
Impedance of leg (right)	0.7	3.5	5.5	2.0	1.9	1.9	2.2	-0.0	2.3
Impedance of leg (left)	0.7	3.3	5.1	1.8	1.7	1.8	2.2	-0.4	2.2
Worry too long after embarrassment	0.7	1.1	3.1	-0.7	0.2	-0.0	-1.6	1.8	-0.8
Age at first live birth	0.7	1.3	4.9	0.1	1.0	1.0	-0.7	2.2	0.6
Angina (self-reported)	0.7	0.9	1.8	0.9	0.8	1.0	0.9	-0.5	1.3
Pulse rate, automated reading	0.7	2.3	4.0	-1.6	-1.6	-1.5	-1.4	-0.6	-2.0
Leg pain on walking	0.7	0.9	2.1	-0.6	-1.0	-1.1	0.3	-1.5	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.3	-1.0	-0.8	-0.8	-1.1	0.1	-1.0
Qualifications: nursing, teaching	0.7	1.1	3.5	-0.9	-0.4	-0.7	-1.9	0.8	-1.0
High cholesterol (Self-reported)	0.7	1.2	1.7	-1.0	-1.3	-1.3	-0.3	-1.1	-1.2
Depression (Nagel 2018)	0.6	1.0	1.9	0.4	1.0	1.2	-0.2	1.4	1.1
Prostate Cancer	0.6	0.9	1.7	-1.2	-0.6	-0.9	-1.3	0.2	-1.0
LDL Cholesterol	0.6	0.9	1.6	-1.3	-0.9	-0.9	-1.3	-0.0	-0.7
Neuroticism	0.6	1.5	1.9	-1.3	-1.4	-1.4	-0.4	-1.2	-1.3
Ever had hysterectomy (womb removed)	0.6	0.7	2.1	0.1	-0.7	-0.9	0.5	-1.4	-0.7
Medication: Co-codamol	0.6	0.7	2.8	0.8	0.2	0.2	1.7	-0.9	0.3
Waist circumference	0.6	2.2	2.9	-1.6	-1.6	-1.7	-1.5	-0.9	-1.5
Had other major operations	0.6	0.7	2.4	-0.2	-0.7	-0.8	0.6	-1.6	-0.6
Forced vital capacity (FVC)	0.6	2.3	6.5	-1.1	-0.2	-0.2	-2.4	2.6	-0.2
Medication: Simvastatin	0.6	0.9	2.6	-0.3	-0.9	-1.1	0.2	-1.6	-0.7
Hair/balding pattern: Pattern 3	0.6	0.8	1.6	0.9	0.6	0.7	1.3	-0.8	1.1
Lung cancer (father)	0.6	0.7	0.9	-1.0	-1.0	-0.9	-0.9	-0.1	-0.8
Hair/balding pattern: Pattern 4	0.6	1.4	4.3	1.1	-0.0	-0.1	2.1	-1.6	0.4
Birth weight	0.6	1.3	3.1	-1.1	0.2	0.1	-1.8	1.7	-0.6
Alcohol intake frequency.	0.6	1.3	2.2	-1.0	-1.3	-1.4	-0.4	-1.5	-1.0
Loneliness, isolation	0.6	0.9	2.1	0.9	0.5	0.6	1.4	-0.7	1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	0.9	0.8	0.7	0.8	0.9	-0.3	0.9
Eye problems/disorders: Cataract	0.6	0.6	1.0	1.0	0.6	0.7	1.0	-0.4	0.9
Miserableness	0.6	1.0	1.9	0.5	1.1	1.0	0.3	1.2	1.4
Hearing aid user	0.6	0.7	2.4	0.3	0.9	0.6	-0.8	1.6	0.2
Mother’s age at death	0.6	0.7	1.2	-1.1	-0.7	-1.0	-0.8	-0.1	-1.0
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.6	-0.8	-1.0	-1.0	-0.1	-1.3	-0.2
Medication: Blood pressure	0.6	1.1	4.0	0.7	-0.4	-0.4	1.3	-2.0	0.0
Unable to work because of sickness or disability	0.6	0.7	1.6	0.7	0.9	0.9	0.7	0.1	1.3
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.5	0.0	0.8	0.6	-0.9	1.6	0.7
Impedance of whole body	0.6	3.1	5.0	1.6	2.0	1.9	1.6	0.7	2.2
Ulcerative Colitis	0.5	0.8	2.2	0.9	0.1	0.4	1.5	-1.0	0.7
Blood White Count	0.5	3.7	5.0	-2.2	-2.2	-2.2	-1.9	-1.0	-1.7
Allergy or Eczema	0.5	1.2	2.7	0.3	1.1	1.2	-0.3	1.3	1.6
Systolic blood pressure, automated reading	0.5	1.5	2.7	-0.7	-1.4	-1.2	0.4	-1.6	-1.4
Serious illness, injury or assault to yourself	0.5	0.6	2.1	0.0	-0.7	-0.6	0.6	-1.5	-0.7
Heart attack	0.5	0.6	1.6	1.1	0.5	0.7	1.3	-0.6	0.3
Allergy	0.5	1.1	2.6	-0.5	-1.1	-1.1	0.2	-1.1	-1.6
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.7	1.0	0.5	0.7	1.3	-0.5	0.7
Illnesses of siblings	0.5	0.6	2.1	0.2	-0.5	-0.3	0.9	-1.5	0.7
Impedance of arm (right)	0.5	2.4	4.0	1.4	1.8	1.7	1.4	0.6	2.0
Noisy workplace	0.5	0.6	0.7	0.8	0.8	0.8	0.9	0.2	0.8
Qualifications: A levels/AS levels or equivalent	0.5	1.2	2.0	-1.1	-0.8	-1.0	-1.4	0.7	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	5.0	0.7	0.8	1.2	-0.3	2.2	1.1
Birth weight of first child	0.5	0.9	2.5	-0.5	0.1	-0.1	-1.6	1.5	0.2
Blood clot in the leg (DVT)	0.5	0.6	1.6	0.1	0.7	0.6	-0.7	1.3	0.7
High blood pressure (siblings)	0.5	0.7	2.2	-0.6	0.2	0.1	-1.1	1.5	-0.6
Health satisfaction	0.5	0.7	2.9	-0.1	-0.7	-0.7	0.5	-1.7	-0.3
Eye problems/disorders: None of the above	0.5	0.6	0.9	-0.7	-0.8	-0.9	-0.8	-0.0	-0.8
Overall health rating	0.5	1.2	4.6	-0.4	-0.9	-0.8	0.6	-2.2	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.4	1.1	0.5	0.7	1.2	-0.2	0.4
Leg fat mass (left)	0.5	1.9	2.4	-1.3	-1.6	-1.6	-1.0	-1.2	-1.5
Intelligence (Savage-Jansen 2018)	0.4	1.1	2.3	-0.8	-1.1	-1.3	-0.5	-0.7	-1.5
Irritable Bowel Disease (IBD)	0.4	0.9	3.3	0.2	-0.6	-0.5	1.0	-1.8	-0.4
Breast Cancer	0.4	1.0	1.9	1.1	0.8	0.7	1.3	-0.3	1.4
Smoking Status	0.4	1.0	2.1	1.3	1.0	1.4	0.9	0.3	0.8
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.2	-1.0	-0.7	-0.6	-1.5	0.0	-0.8
Average weekly spirits intake	0.4	0.5	1.1	-0.3	-0.9	-0.7	-0.1	-1.0	-0.5
Angina	0.4	0.6	1.4	0.7	0.7	1.0	0.4	-0.2	1.2
Diabetes (mother)	0.4	0.5	2.2	-0.0	0.4	0.6	-0.7	1.5	-0.2
Relative age voice broke	0.4	0.6	1.6	0.5	0.8	0.9	0.1	0.6	1.3
High blood pressure (mother)	0.4	0.6	0.9	0.7	1.0	0.7	0.6	0.6	0.8
Trunk fat mass	0.4	1.9	2.3	-1.5	-1.4	-1.5	-1.4	-0.6	-1.5
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	0.7	-0.5	-0.9	-0.8	-0.5	-0.3	-0.8
Number of live births	0.4	0.5	1.2	0.5	0.7	0.9	0.4	1.1	0.6
Pulse rate	0.4	0.6	1.5	1.2	0.5	0.6	1.0	-0.7	0.6
Impedance of arm (left)	0.4	1.6	2.5	1.1	1.6	1.4	0.8	1.0	1.6
Length of working week for main job	0.4	0.4	0.9	-0.6	-0.9	-0.8	0.0	-1.0	-0.2
Tense / ‘highly strung’	0.4	0.6	1.3	0.7	0.6	0.4	1.2	-1.0	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.0	-0.7	-1.0	-0.8	0.0	-1.0	-0.9
Ever highly irritable/argumentative for 2 days	0.4	0.5	2.0	0.2	-0.5	-0.4	0.7	-1.4	-0.5
Headache pain in last month	0.4	0.6	1.4	-1.2	-0.9	-0.9	-0.6	-0.6	-0.1
Glaucoma (self-reported)	0.4	0.5	1.9	0.5	0.5	0.5	0.2	0.3	1.4
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.0	-0.7	-1.0	-0.7	-0.4	-0.5	-0.8
Wheeze or whistling in the chest in last year	0.4	0.7	1.3	-1.1	-0.8	-0.9	-1.1	0.2	-0.3
Medication for pain relief, constipation, heartburn	0.4	0.7	2.5	0.4	1.0	0.8	-0.3	1.6	0.1
Neck or shoulder pain in last month	0.4	0.6	1.1	-0.7	-0.4	-0.7	-1.1	0.6	-0.8
Migraine (self-reported)	0.4	0.5	1.1	-1.0	-0.7	-0.6	-0.9	-0.1	-0.6
Medication: Omeprazole	0.4	0.4	1.2	0.5	0.2	0.4	1.1	-0.6	0.8
Whole body fat mass	0.4	1.5	1.9	-1.2	-1.3	-1.4	-1.2	-0.8	-1.3
Leg fat mass (right)	0.4	1.7	2.3	-1.1	-1.5	-1.5	-0.9	-1.2	-1.5
Commuting to job workplace: Car/motor vehicle	0.4	0.4	0.7	0.8	0.7	0.5	0.8	-0.2	0.7
Supplements: Vitamin C	0.4	0.5	0.9	-0.4	-0.8	-0.8	-0.4	-0.7	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.4	-0.5	0.1	-0.0	-1.4	1.5	-0.2
Arm fat mass (left)	0.4	1.8	2.4	-1.5	-1.4	-1.4	-1.6	-0.5	-1.5
Guilty feelings	0.4	0.7	1.0	-0.9	-1.0	-0.9	-0.5	-0.8	-0.8
Medication: Atorvastatin	0.4	0.5	1.6	-0.1	-0.6	-0.5	0.6	-1.2	-0.6
Fractured/broken bones in last 5 years	0.4	0.5	1.4	0.7	0.0	-0.1	1.2	-1.1	-0.4
Ulcerative Colitis (UC)	0.3	0.6	1.5	-0.3	-0.6	-0.9	0.4	-1.2	-0.7
Crohns Disease (2012)	0.3	0.4	1.0	0.7	0.0	0.3	1.0	-0.9	0.3
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.0	-0.4	-0.3	-0.1	-1.0	0.5	-0.6
Blood Red Count	0.3	2.9	5.0	-2.0	-1.4	-1.6	-2.2	0.8	-1.8
Relative age of first facial hair	0.3	0.7	2.5	-0.6	-1.0	-0.7	-0.1	-1.6	-0.1
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	0.8	-0.5	-0.0	-0.1	-0.9	0.7	-0.9
Medication for hormone replacement therapy	0.3	0.4	0.6	-0.3	-0.8	-0.8	0.3	-0.8	-0.3
Severe depression (siblings)	0.3	0.3	0.6	-0.3	-0.8	-0.7	-0.3	-0.7	-0.4
Townsend deprivation index at recruitment	0.3	0.4	1.4	0.1	-0.3	-0.2	0.9	-1.2	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.0	-0.4	0.1	0.4	-0.8	1.0	0.2
Taking other prescription medications	0.3	0.5	0.9	-0.7	-0.7	-0.8	-0.6	-1.0	0.1
Number of incorrect matches in round	0.3	0.5	1.5	0.4	0.0	0.1	1.2	-1.1	0.3
Hip circumference	0.3	1.2	2.8	-1.3	-0.8	-0.7	-1.7	0.9	-1.0
Worrier / anxious feelings	0.3	0.5	1.0	-0.9	-0.4	-0.5	-1.0	0.6	-0.8
Happiness	0.3	0.3	0.6	-0.5	-0.3	-0.3	-0.8	0.7	-0.6
Medication: Cholesterol lowering	0.3	0.5	1.3	0.6	-0.1	0.2	1.0	-1.1	0.2
Illnesses of mother	0.3	0.4	0.8	0.5	0.9	0.6	0.3	0.6	0.7
Arm fat mass (right)	0.3	1.2	1.5	-1.1	-1.1	-1.2	-1.2	-0.5	-1.2
Peak expiratory flow (PEF)	0.3	0.8	2.1	-0.3	0.1	-0.1	-1.4	1.4	-0.6
Medication for cholesterol, blood pressure or diabetes	0.3	0.6	1.2	-0.8	-0.3	-0.4	-1.1	1.0	-0.4
Forced vital capacity (FVC), Best measure	0.3	0.9	3.2	-0.5	-0.3	-0.0	-1.4	1.8	-0.1
Exposure to tobacco smoke outside home	0.3	0.4	0.9	-0.0	-0.6	-0.5	0.3	-0.8	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	1.2	-0.6	-0.1	-0.3	-1.1	0.6	-0.2
Number of full sisters	0.3	0.4	0.6	0.6	0.6	0.7	0.5	0.7	0.8
Had major operations	0.3	0.3	1.1	-0.5	-0.5	-0.4	-1.0	0.4	-0.1
Hypertension (Self-reported)	0.3	0.7	1.5	1.2	0.4	0.4	1.2	-0.9	0.6
Diabetes diagnosed by doctor	0.3	0.5	2.0	-0.6	-0.3	-0.4	-1.4	0.2	-0.3
Mineral and other dietary supplements	0.3	0.4	0.6	0.5	0.8	0.8	0.2	0.7	0.8
Asthma (self-reported)	0.3	0.6	1.7	-1.0	-0.4	-0.4	-1.3	0.5	-0.3
Osteoporosis (self-reported)	0.3	0.3	1.2	0.0	-0.6	-0.4	0.4	-1.1	0.3
Commuting to job workplace: Public transport	0.3	0.3	0.8	-0.8	-0.3	-0.3	-0.9	0.1	-0.7
Medication: Paracetamol	0.3	0.4	1.2	-0.2	-0.6	-0.8	0.3	-1.1	-0.2
Number of operations (self-reported)	0.3	0.4	0.7	-0.5	-0.8	-0.6	-0.0	-0.8	-0.7
Risk taking	0.3	0.4	1.0	-0.5	-0.8	-0.5	0.0	-1.0	-0.5
Vascular/heart problems diagnosed by doctor	0.3	0.7	1.4	-1.1	-0.2	-0.4	-1.2	1.1	-0.6
Pain experienced in last month	0.3	0.5	1.1	-0.7	-0.5	-0.4	-0.9	0.3	-1.0
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.0	0.8	0.2	0.4	1.0	-0.6	0.0
Alcohol drinker status: Previous	0.3	0.3	0.8	-0.7	-0.5	-0.4	-0.9	0.1	-0.4
Bipolar Disorder (2018)	0.2	0.3	0.9	0.8	-0.1	0.2	1.0	-0.7	0.2
Schizophrenia (2018)	0.2	0.3	0.8	-0.2	0.1	0.4	-0.8	0.9	0.5
Schizophrenia vs Biploar Disorder	0.2	0.3	0.6	0.3	0.7	0.7	0.0	0.8	0.4
Worry (Nagel 2018)	0.2	0.5	0.8	-0.8	-0.9	-0.7	-0.2	-0.6	-0.7
Crohns Disease (2017)	0.2	0.5	1.6	-0.1	-0.7	-0.4	0.5	-1.3	-0.5
Reaction Time	0.2	0.4	0.9	0.3	0.6	0.7	-0.0	1.0	0.7
Bipolar Disorder (2011)	0.2	0.2	0.2	-0.5	-0.4	-0.4	-0.3	-0.5	-0.3
HbA1C	0.2	0.2	0.5	-0.5	-0.4	-0.4	-0.7	0.1	-0.6
Blood Platelet Count	0.2	2.1	3.5	-1.9	-1.5	-1.5	-1.8	-0.5	-1.0
Hand grip strength (left)	0.2	0.5	1.6	-0.3	-0.2	0.1	-1.1	1.2	0.1
Fed-up feelings	0.2	0.4	0.7	-0.8	-0.5	-0.8	-0.2	-0.5	-0.8
Age when periods started (menarche)	0.2	0.5	0.7	-0.8	-0.7	-0.7	-0.8	-0.0	-0.9
High blood pressure	0.2	0.5	1.1	1.1	0.2	0.3	1.0	-0.8	0.5
Stomach or abdominal pain in last month	0.2	0.2	0.5	-0.2	-0.4	-0.5	0.3	-0.7	-0.3
Neuroticism score	0.2	0.3	0.9	-0.5	-0.6	-0.5	0.2	-1.0	-0.4
Alcohol intake versus 10 years previously	0.2	0.3	1.0	0.4	0.0	0.1	0.7	-0.6	1.0
Asthma	0.2	0.3	0.9	-0.8	-0.4	-0.5	-1.0	0.1	-0.3
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.1	-0.5	-0.4	-0.5	-1.0	0.5	-0.6
Medication: Paracetamol	0.2	0.3	1.1	-0.2	-0.6	-0.7	0.2	-1.0	0.1
Gout (self-reported)	0.2	0.2	0.6	-0.1	0.1	0.3	-0.7	0.8	-0.5
Medication: Amlodipine	0.2	0.3	0.9	0.3	-0.0	0.2	0.9	-0.8	0.4
Mean time to correctly identify matches	0.2	0.3	0.5	0.5	0.6	0.7	0.4	0.5	0.6
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.4	0.3	0.6	0.7	0.2	0.6	0.5
Knee pain experienced in last month	0.2	0.4	1.3	0.3	-0.2	-0.2	0.9	-1.1	0.2
Average weekly red wine intake	0.2	0.3	0.9	-0.2	0.5	0.5	-0.5	0.9	0.2
Mood swings	0.2	0.3	1.0	-0.5	0.4	0.3	-0.7	1.0	0.1
Back pain experienced in last month	0.2	0.3	0.8	0.3	-0.1	-0.1	0.8	-0.9	-0.3
Ever smoked	0.2	0.3	0.6	0.8	0.5	0.7	0.7	0.2	0.1
Irritability	0.2	0.3	0.5	-0.5	-0.7	-0.5	-0.1	-0.6	-0.7
Ever depressed for a whole week	0.2	0.3	0.9	0.3	-0.3	-0.4	0.7	-1.0	-0.3
Supplements: Calcium	0.2	0.2	0.7	-0.3	-0.4	-0.6	-0.3	-0.1	-0.8
Basal cell carcinoma (self-reported)	0.2	0.2	0.9	0.1	-0.3	-0.4	0.2	-1.0	0.2
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.4	-0.5	-0.5	-0.4	-0.2	0.0	-0.6
Rheumatoid Arthritis	0.1	0.1	0.4	0.0	0.2	0.3	-0.2	0.2	0.7
Schizophrenia (2014)	0.1	0.2	0.3	0.6	0.2	0.5	0.0	0.3	0.6
BMI	0.1	0.5	0.7	-0.6	-0.6	-0.8	-0.5	-0.8	-0.9
Cardiovascular Disease	0.1	0.5	0.9	-0.2	-0.8	-0.8	-0.1	-0.8	-0.9
Tanning	0.1	0.7	1.3	1.1	0.7	1.1	0.7	0.4	0.8
Medication: Metformin	0.1	0.1	0.3	0.5	0.4	0.2	-0.1	0.1	0.2
Hand grip strength (right)	0.1	0.4	1.2	0.6	0.5	0.6	-0.3	1.1	0.4
Maternal smoking around birth	0.1	0.1	0.3	0.1	0.2	0.2	-0.2	0.5	0.2
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	-0.1	0.1	0.0	-0.2	0.5	-0.3
Body mass index (BMI)	0.1	0.4	0.7	-0.4	-0.6	-0.7	-0.5	-0.7	-0.9
Alcohol usually taken with meals	0.1	0.2	0.9	-0.3	-0.1	-0.3	0.3	-0.9	-0.1
Nervous feelings	0.1	0.2	0.5	-0.7	-0.5	-0.6	-0.2	-0.1	-0.4
Diabetes (self-reported)	0.1	0.1	0.4	-0.1	-0.1	-0.2	-0.6	-0.2	-0.2
Medication: Ramipril	0.1	0.1	0.2	-0.2	-0.3	-0.1	-0.2	-0.4	-0.3
Fluid intelligence score	0.1	0.2	0.4	-0.4	-0.6	-0.4	-0.3	-0.0	-0.7
Mouth/teeth dental problems: Dentures	0.1	0.1	0.2	0.2	0.5	0.4	-0.4	0.2	0.2
Exposure to tobacco smoke at home	0.1	0.1	0.4	-0.0	0.2	0.4	-0.3	0.6	0.4
Breastfed as a baby	0.1	0.1	0.2	0.4	0.2	0.1	0.4	0.0	0.4
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.4	-0.1	0.3	0.3	0.0	0.7	-0.4
Leg fat percentage (right)	0.1	0.4	2.0	0.2	-0.2	-0.2	0.7	-1.4	-0.2
Comparative body size at age 10	0.1	0.4	1.1	-0.2	-0.0	0.1	-0.4	1.1	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.3	0.2	0.1	0.4	0.6	-0.1	0.4
Medication: Allopurinol	0.1	0.1	0.2	0.3	-0.1	0.2	0.3	-0.4	-0.4
Medication: Seretide 50 evohaler	0.1	0.1	0.5	0.2	-0.1	-0.1	0.2	-0.7	-0.4
Commuting to job workplace: Walk	0.1	0.1	0.5	-0.2	0.1	0.1	-0.2	0.7	-0.1
Medication for cholesterol	0.1	0.1	0.3	0.1	0.5	0.5	0.0	0.6	0.3
Osteoarthritis (self-reported)	0.1	0.2	0.3	-0.2	-0.4	-0.6	-0.3	-0.6	-0.3
Medication: Gliclazide	0.1	0.1	0.2	0.4	0.2	0.2	0.1	-0.2	0.4
Illnesses of father: None of the above (group 1)	0.1	0.2	0.5	-0.1	0.1	0.1	-0.5	0.7	0.5
Number of self-reported non-cancer illnesses	0.1	0.2	0.4	0.6	0.2	0.5	0.6	-0.6	0.3
Financial situation satisfaction	0.1	0.1	0.5	0.4	-0.2	-0.2	0.7	-0.3	-0.1
Alcohol drinker status: Never	0.1	0.1	0.3	0.0	0.4	0.2	-0.2	0.6	0.3
Leg fat percentage (left)	0.1	0.5	2.5	0.1	-0.3	-0.4	0.6	-1.6	-0.3
Commuting to job workplace: Cycle	0.1	0.2	0.6	0.2	0.3	0.4	0.2	0.8	0.1
Myopia	0.1	0.2	0.5	-0.3	-0.4	-0.4	-0.1	-0.7	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.5	-0.4	-0.7	-0.4	0.2	-0.3	-0.1
Heart disease (siblings)	0.1	0.1	0.2	0.2	0.5	0.2	-0.0	0.1	0.1
Bipolar Disorder or Schizophrenia	0.0	0.1	0.2	0.4	0.1	0.4	-0.0	0.3	0.5
Depressed Affect (Nagel 2018)	0.0	0.0	0.1	-0.1	0.2	0.0	0.1	0.3	0.1
Neuroticism (Nagel 2018)	0.0	0.1	0.2	-0.4	-0.2	-0.2	-0.0	0.1	-0.3
Coronary Artery Disease (CAD)	0.0	0.1	0.2	-0.1	0.1	-0.2	-0.4	0.2	0.2
HDL Cholesterol	0.0	0.1	0.2	-0.2	-0.1	-0.2	-0.1	-0.5	0.2
Systolic Blood Pressure	0.0	0.2	0.4	-0.6	-0.4	-0.2	-0.6	0.1	-0.4
Hair Pigment	0.0	0.2	0.4	-0.4	-0.2	-0.2	-0.5	-0.3	-0.7
Frequency of depressed mood in last 2 weeks	0.0	0.1	0.2	0.1	0.4	0.4	0.1	0.1	0.3
Trunk fat percentage	0.0	0.2	0.8	-0.3	-0.2	-0.4	0.0	-0.9	-0.4
Supplements: Glucosamine	0.0	0.0	0.1	-0.0	-0.1	-0.0	0.2	-0.3	-0.3
Arm fat percentage (right)	0.0	0.1	0.5	0.3	0.2	0.1	0.3	-0.7	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.2	-0.1	-0.2	-0.1	-0.5	0.0	-0.1
Body fat percentage	0.0	0.2	0.9	0.2	0.1	-0.0	0.5	-0.9	-0.1
Arm fat percentage (left)	0.0	0.2	0.6	-0.1	-0.2	-0.4	-0.1	-0.7	-0.5
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.1	-0.0	-0.2	0.2	0.1	0.1	0.3
Friendships satisfaction	0.0	0.0	0.1	0.1	-0.2	-0.3	0.1	-0.0	-0.2

Hub : Genes

CCNO

Models

Trait associations